PharmaCoNets

PharmaCoNets of Bepridil (S_PCN: 125.73 )

Bepridil regulated-network (S_DN: 24.37)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Bepridil

hsa00030

Pentose phosphate pathway

3.06E-04

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Bepridil

hsa00040

Pentose and glucuronate interconversions

9.59E-03

P15121, P14550

AKR1B1, AKR1A1

Bepridil

hsa00052

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Bepridil

hsa00190

Oxidative phosphorylation

3.92E-05

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Bepridil

hsa00220

Arginine biosynthesis

4.97E-04

P15104, P49448

GLUL, GLUD2

Bepridil

hsa00230

Purine metabolism

4.60E-02

Q13370, P36959, Q13956, P27707

PDE3B, GMPR, PDE6H, DCK

Bepridil

hsa00240

Pyrimidine metabolism

4.01E-03

P21589, P32320, P27707, P04183

NT5E, CDA, DCK, TK1

Bepridil

hsa00250

Alanine, aspartate and glutamate metabolism

1.20E-03

P49448, P15104

GLUD2, GLUL

Bepridil

hsa00310

Lysine degradation

2.59E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Bepridil

hsa00500

Starch and sucrose metabolism

1.67E-02

O43451, P06737

MGAM, PYGL

Bepridil

hsa00512

Mucin type O-glycan biosynthesis

4.86E-02

O95395, Q9NY28

GCNT3, GALNT8

Bepridil

hsa00513

Various types of N-glycan biosynthesis

4.96E-02

Q9NR34

MAN1C1

Bepridil

hsa00534

Glycosaminoglycan biosynthesis - heparan sulfate / heparin

4.77E-02

Q7LGA3

HS2ST1

Bepridil

hsa00561

Glycerolipid metabolism

7.94E-03

P15121, P14550, Q86XP1

AKR1B1, AKR1A1, DGKH

Bepridil

hsa00564

Glycerophospholipid metabolism

4.29E-02

Q6P1A2, P23743

MBOAT5, DGKA

Bepridil

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Bepridil

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Bepridil

hsa00630

Glyoxylate and dicarboxylate metabolism

1.23E-04

P40925, P15104

MDH1, GLUL

Bepridil

hsa00640

Propanoate metabolism

3.83E-02

Q02252, Q9P2R7

ALDH6A1, SUCLA2

Bepridil

hsa00670

One carbon pool by folate

3.99E-02

O95954, Q99707

FTCD, MTR

Bepridil

hsa00730

Thiamine metabolism

5.29E-03

P05186, P24666

ALPL, ACP1

Bepridil

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Bepridil

hsa00910

Nitrogen metabolism

1.20E-03

P15104, P49448

GLUL, GLUD2

Bepridil

hsa00920

Sulfur metabolism

3.01E-02

O95571

ETHE1

Bepridil

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Bepridil

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Bepridil

hsa00983

Drug metabolism - other enzymes

2.44E-02

P32320, P05164

CDA, MPO

Bepridil

hsa01100

Metabolic pathways

3.95E-02

Q9Y234, Q99707, P29218, P11310, P27707, Q13370, P36959, Q13956, P30043, Q02252, O60701, O14772, O95954, Q02318, P04406, O15466, P09960, Q9P2R7, Q9UHY7, P35573, Q13488, Q16718, Q02809

LIPT1, MTR, IMPA1, ACADM, DCK, PDE3B, GMPR, PDE6H, BLVRB, ALDH6A1, UGDH, FPGT, FTCD, CYP27A1, GAPDH, ST8SIA5, LTA4H, SUCLA2, ENOPH1, AGL, TCIRG1, NDUFA5, PLOD1

Bepridil

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Bepridil

hsa01230

Biosynthesis of amino acids

1.16E-03

P51854, P60891, P15104, P37837

TKTL1, PRPS1, GLUL, TALDO1

Bepridil

hsa01523

Antifolate resistance

3.80E-02

Q92820, P04818

GGH, TYMS

Bepridil

hsa01524

Platinum drug resistance

4.45E-02

P10415, Q13489, P78417, P43246

BCL2, BIRC3, GSTO1, MSH2

Bepridil

hsa02010

ABC transporters

1.63E-03

P45844, P08183, Q99758

ABCG1, ABCB1, ABCA3

Bepridil

hsa03010

Ribosome

1.60E-02

P30050, P40429, P62906, P62917, Q9H0U6, P36578, P05386, P62249, P23396

RPL12, RPL13A, RPL10A, RPL8, MRPL18, RPL4, RPLP1, RPS16, RPS3

Bepridil

hsa03013

RNA transport

4.79E-02

P62826, P63279

RAN, UBE2I

Bepridil

hsa03015

mRNA surveillance pathway

3.62E-02

O43148, P61326, P52298

RNMT, MAGOH, NCBP2

Bepridil

hsa03020

RNA polymerase

9.86E-07

Q9GZM3, P52435

POLR2J2, POLR2J

Bepridil

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Bepridil

hsa03030

DNA replication

1.48E-02

P49005, P33993, P15927

POLD2, MCM7, RPA2

Bepridil

hsa03040

Spliceosome

1.29E-11

Q14562, O43143, O60508, P17844, O14776, P08579, O75940, P52298, P09651, Q15365, O75494, Q07955, Q01130, Q13243, P11142, O95777, O43447, O75643, P61326

DHX8, DHX15, CDC40, DDX5, TCERG1, SNRPB2, SMNDC1, NCBP2, HNRNPA1, PCBP1, FUSIP1, SFRS1, SFRS2, SFRS5, HSPA8, LSM8, PPIH, ASCC3L1, MAGOH

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.942
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.803
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.775
P0DP25	CALM3	Calmodulin-3	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.942
P0DP24	CALM2	Calmodulin-2	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.942
P0DP23	CALM1	Calmodulin-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.963
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.869
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.871
P0DP25	CALM3	Calmodulin-3	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.963
P0DP24	CALM2	Calmodulin-2	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.963
P0DP23	CALM1	Calmodulin-1	O60508	CDC40	Pre-mRNA-processing factor 17	0.828
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O60508	CDC40	Pre-mRNA-processing factor 17	0.827
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O60508	CDC40	Pre-mRNA-processing factor 17	0.716
P0DP25	CALM3	Calmodulin-3	O60508	CDC40	Pre-mRNA-processing factor 17	0.828
P0DP24	CALM2	Calmodulin-2	O60508	CDC40	Pre-mRNA-processing factor 17	0.828
P0DP24	CALM2	Calmodulin-2	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.734
O15182	CETN3	Centrin-3	O14776	TCERG1	Transcription elongation regulator 1	0.758
P0DP23	CALM1	Calmodulin-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.781
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.778
P0DP25	CALM3	Calmodulin-3	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.781
P0DP24	CALM2	Calmodulin-2	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.781
O15182	CETN3	Centrin-3	O75940	SMNDC1	Survival of motor neuron-related-splicing factor 30	0.859
O15182	CETN3	Centrin-3	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.701
O15182	CETN3	Centrin-3	P09651	HNRNPA1	Heterogeneous nuclear ribonucleoprotein A1	0.757
P0DP24	CALM2	Calmodulin-2	Q15365	PCBP1	Poly(rC)-binding protein 1	0.75
O15182	CETN3	Centrin-3	O75494	FUSIP1	Serine/arginine-rich splicing factor 10	0.85
P0DP23	CALM1	Calmodulin-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.866
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.827
P0DP25	CALM3	Calmodulin-3	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P0DP24	CALM2	Calmodulin-2	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P0DP23	CALM1	Calmodulin-1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.835
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.783
P0DP25	CALM3	Calmodulin-3	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P0DP24	CALM2	Calmodulin-2	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P0DP23	CALM1	Calmodulin-1	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.908
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.943
P0DP25	CALM3	Calmodulin-3	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP24	CALM2	Calmodulin-2	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP23	CALM1	Calmodulin-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.804
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.928
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.876
P0DP25	CALM3	Calmodulin-3	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.804
P0DP24	CALM2	Calmodulin-2	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.804
O15182	CETN3	Centrin-3	O95777	LSM8	U6 snRNA-associated Sm-like protein LSm8	0.723
P0DP23	CALM1	Calmodulin-1	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.786
P0DP25	CALM3	Calmodulin-3	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.748
P0DP24	CALM2	Calmodulin-2	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	0.78
O15182	CETN3	Centrin-3	P61326	MAGOH	Protein mago nashi homolog	0.811

Bepridil

hsa03050

Proteasome

5.53E-03

P43686, P28070

PSMC4, PSMB4

Bepridil

hsa03320

PPAR signaling pathway

2.18E-02

O00767, Q02318

SCD, CYP27A1

Bepridil

hsa03460

Fanconi anemia pathway

3.70E-03

Q9NPI8, O60673, Q9UNA4

FANCF, REV3L, POLI

Bepridil

hsa04012

ErbB signaling pathway

1.34E-02

P16333, P19174, P42338, P01106

NCK1, PLCG1, PIK3CB, MYC

Bepridil

hsa04014

Ras signaling pathway

3.00E-07

P31751, P42338, P20827, Q9NRA1, P49767, Q13009, P17252, Q15311, P0DP23, P62873, P63218, P50151, P19174

AKT2, PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, PRKCA, RALBP1, CALM1, GNB1, GNG5, GNG10, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P0DP23	CALM1	Calmodulin-1	P20827	EFNA1	Ephrin-A1	-0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P20827	EFNA1	Ephrin-A1	-0.743
P0DP25	CALM3	Calmodulin-3	P20827	EFNA1	Ephrin-A1	-0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.776
P0DP23	CALM1	Calmodulin-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P0DP25	CALM3	Calmodulin-3	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP23	CALM1	Calmodulin-1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.788
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.748
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.746
P0DP25	CALM3	Calmodulin-3	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.788
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	Q15311	RALBP1	RalA-binding protein 1	0.858
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P0DP25	CALM3	Calmodulin-3	P0DP23	CALM1	Calmodulin-1	1
P0DP23	CALM1	Calmodulin-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P0DP25	CALM3	Calmodulin-3	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P0DP25	CALM3	Calmodulin-3	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744

Bepridil

hsa04015

Rap1 signaling pathway

1.76E-05

P20827, Q9NRA1, P49767, P11215, P25116, Q8TEU7, Q13009, Q08828, P51828, P42338, P31751, P0DP23, P08514, P17252, P19174

EFNA1, PDGFC, VEGFC, ITGAM, F2R, RAPGEF6, TIAM1, ADCY1, ADCY7, PIK3CB, AKT2, CALM1, ITGA2B, PRKCA, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P20827	EFNA1	Ephrin-A1	-0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P20827	EFNA1	Ephrin-A1	-0.743
P0DP25	CALM3	Calmodulin-3	P20827	EFNA1	Ephrin-A1	-0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
P0DP23	CALM1	Calmodulin-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P0DP25	CALM3	Calmodulin-3	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11215	ITGAM	Integrin alpha-M	-0.877
P25116	F2R	Proteinase-activated receptor 1	P25116	F2R	Proteinase-activated receptor 1	1
P25116	F2R	Proteinase-activated receptor 1	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.811
P0DP23	CALM1	Calmodulin-1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.788
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.748
P0DP25	CALM3	Calmodulin-3	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.788
P0DP23	CALM1	Calmodulin-1	Q08828	ADCY1	Adenylate cyclase type 1	0.725
P0DP23	CALM1	Calmodulin-1	P51828	ADCY7	Adenylate cyclase type 7	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P0DP25	CALM3	Calmodulin-3	P0DP23	CALM1	Calmodulin-1	1
P25116	F2R	Proteinase-activated receptor 1	P08514	ITGA2B	Integrin alpha-IIb	0.813
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P25116	F2R	Proteinase-activated receptor 1	P17252	PRKCA	Protein kinase C alpha type	0.857
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P0DP25	CALM3	Calmodulin-3	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744

Bepridil

hsa04020

Calcium signaling pathway

4.75E-10

P27987, Q96DU7, Q08828, P21796, Q13557, P17252, P21860, O15399, P19174, P61073, P0DP23, P05141, P12236, P51828, P26678, P63092, P23634, Q9NRA1, P49767

ITPKB, ITPKC, ADCY1, VDAC1, CAMK2D, PRKCA, ERBB3, GRIN2D, PLCG1, CXCR4, CALM1, SLC25A5, SLC25A6, ADCY7, PLN, GNAS, ATP2B4, PDGFC, VEGFC

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.891
P0DP25	CALM3	Calmodulin-3	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.701
P0DP24	CALM2	Calmodulin-2	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.701
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.766
P0DP23	CALM1	Calmodulin-1	Q08828	ADCY1	Adenylate cyclase type 1	0.725
P0DP24	CALM2	Calmodulin-2	Q08828	ADCY1	Adenylate cyclase type 1	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.72
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.749
P0DP24	CALM2	Calmodulin-2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.786
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P40926	MDH2	Malate dehydrogenase, mitochondrial	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.731
P0DP23	CALM1	Calmodulin-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.764
P0DP25	CALM3	Calmodulin-3	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.764
P0DP24	CALM2	Calmodulin-2	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.764
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P0DP25	CALM3	Calmodulin-3	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P61073	CXCR4	C-X-C chemokine receptor type 4	0.759
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P0DP25	CALM3	Calmodulin-3	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P0DP23	CALM1	Calmodulin-1	1
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.725
P40926	MDH2	Malate dehydrogenase, mitochondrial	P12236	SLC25A6	ADP/ATP translocase 3	0.722
P0DP23	CALM1	Calmodulin-1	P51828	ADCY7	Adenylate cyclase type 7	0.719
P40926	MDH2	Malate dehydrogenase, mitochondrial	P26678	PLN	Cardiac phospholamban	-0.71
P40926	MDH2	Malate dehydrogenase, mitochondrial	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	0.736
P0DP23	CALM1	Calmodulin-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.793
P0DP25	CALM3	Calmodulin-3	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.793
P0DP24	CALM2	Calmodulin-2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.793
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
P0DP23	CALM1	Calmodulin-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P0DP25	CALM3	Calmodulin-3	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP24	CALM2	Calmodulin-2	P49767	VEGFC	Vascular endothelial growth factor C	-0.84

Bepridil

hsa04022

cGMP-PKG signaling pathway

9.36E-03

P61586, P26678, Q99941, P18848, P05141, P12236

RHOA, PLN, CREBL1, ATF4, SLC25A5, SLC25A6

Bepridil

hsa04024

cAMP signaling pathway

3.01E-03

Q08828, P51828, P31751, P0DP23, P23634, Q13557, Q13370, O15399, Q13009

ADCY1, ADCY7, AKT2, CALM1, ATP2B4, CAMK2D, PDE3B, GRIN2D, TIAM1

Bepridil

hsa04062

Chemokine signaling pathway

4.41E-07

P51684, Q8NHW4, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q08828, P51828, Q13009, P14598, P42224, P31751, P25963

CCR6, CCL4L2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ADCY1, ADCY7, TIAM1, NCF1, STAT1, AKT2, NFKBIA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P51684	CCR6	C-C chemokine receptor type 6	-0.734
P0DP23	CALM1	Calmodulin-1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.729
P0DP23	CALM1	Calmodulin-1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.729
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P0DP23	CALM1	Calmodulin-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P43250	GRK6	G protein-coupled receptor kinase 6	-0.775
P0DP23	CALM1	Calmodulin-1	Q08828	ADCY1	Adenylate cyclase type 1	0.725
P0DP23	CALM1	Calmodulin-1	P51828	ADCY7	Adenylate cyclase type 7	0.719
P0DP23	CALM1	Calmodulin-1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.788
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.748
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.746
P0DP23	CALM1	Calmodulin-1	P14598	NCF1	Neutrophil cytosol factor 1	0.854
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P0DP23	CALM1	Calmodulin-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818

Bepridil

hsa04064

NF-kappa B signaling pathway

2.28E-04

P10415, Q13489, P51617, P01584, P29965, P19174, O75293, Q8NHW4, Q9NQC7

BCL2, BIRC3, IRAK1, IL1B, CD40LG, PLCG1, GADD45B, CCL4L2, CYLD

Bepridil

hsa04070

Phosphatidylinositol signaling system

1.88E-06

P19174, P0DP23, P42338, P23743, P48426, P27987, P17252

PLCG1, CALM1, PIK3CB, DGKA, PIP4K2A, ITPKB, PRKCA

Bepridil

hsa04071

Sphingolipid signaling pathway

1.21E-04

P17252, P21453, Q9H228, P01375, Q13510, Q13362, P10415, Q9UQC2, P01042

PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, BCL2, GAB2, KNG1

Bepridil

hsa04072

Phospholipase D signaling pathway

2.78E-03

P31751, P42338, P19174, P17252, Q14344, Q15438, Q08828, P51828, P23743, Q9NRA1, P00734

AKT2, PIK3CB, PLCG1, PRKCA, GNA13, PSCD1, ADCY1, ADCY7, DGKA, PDGFC, F2

Bepridil

hsa04080

Neuroactive ligand-receptor interaction

1.97E-02

P28472, P21453, Q9H228, P21730, P07550

GABRB3, S1PR1, EDG8, C5AR1, ADRB2

Bepridil

hsa04110

Cell cycle

6.80E-03

P06493, O75293, P30304, P33981, P42773, P01106

CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC

Bepridil

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Bepridil

hsa04140

Autophagy - animal

2.58E-02

P31751, Q7L523, Q96RR4, O75460, P10415, Q96GC9, Q8TEV9

AKT2, RRAGA, CAMKK2, ERN1, BCL2, TMEM49, SMCR8

Bepridil

hsa04141

Protein processing in endoplasmic reticulum

8.60E-03

P30101, P60604, P11142, P08238, Q9H173, Q9UNL2

PDIA3, UBE2G2, HSPA8, HSP90AB1, SIL1, SSR3

Bepridil

hsa04142

Lysosome

2.64E-02

Q99437, P25774

ATP6V0B, CTSS

Bepridil

hsa04144

Endocytosis

8.99E-03

P11142, Q9H444, O43633, O75351, Q9NZZ3, Q15438, Q14161, P14784, Q96QK1, Q9UMY4, Q9Y5X3, Q9UNH7

HSPA8, CHMP4B, CHMP2A, VPS4B, CHMP5, PSCD1, GIT2, IL2RB, VPS35, SNX12, SNX5, SNX6

Bepridil

hsa04145

Phagosome

4.35E-06

P11215, P60709, P63261, Q15075, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, Q99437, O60603, P25774

ITGAM, ACTB, ACTG1, EEA1, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, ATP6V0B, TLR2, CTSS

Bepridil

hsa04151

PI3K-Akt signaling pathway

1.12E-06

P42338, P21860, P43657, P01106, O43521, P27348, P09603, P20827, O14944, Q9NRA1, P49767, Q9GZP0, Q13362, P07900, P08238, Q15831, P62873, P63218, P50151, P13612, P16144, O15335, Q13751, P22105, P48551, P14784, P23458, P01568, P15336, Q99941, P18848, P10415, P17252, Q16513, Q6ZUJ8, O95988

PIK3CB, ERBB3, P2RY5, MYC, BCL2L11, YWHAQ, CSF1, EFNA1, EREG, PDGFC, VEGFC, PDGFD, PPP2R5C, HSP90AA1, HSP90AB1, STK11, GNB1, GNG5, GNG10, ITGA4, ITGB4, CHAD, LAMB3, TNXB, IFNAR2, IL2RB, JAK1, IFNA21, ATF2, CREBL1, ATF4, BCL2, PRKCA, PKN2, PIK3AP1, TCL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40926	MDH2	Malate dehydrogenase, mitochondrial	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.731
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.702
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P0DP24	CALM2	Calmodulin-2	O43521	BCL2L11	Bcl-2-like protein 11	0.75
P40926	MDH2	Malate dehydrogenase, mitochondrial	P27348	YWHAQ	14-3-3 protein theta	0.711
P0DP24	CALM2	Calmodulin-2	P27348	YWHAQ	14-3-3 protein theta	0.777
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.789
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P20827	EFNA1	Ephrin-A1	-0.743
P0DP24	CALM2	Calmodulin-2	P20827	EFNA1	Ephrin-A1	-0.795
P40926	MDH2	Malate dehydrogenase, mitochondrial	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.778
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P0DP24	CALM2	Calmodulin-2	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.736
P0DP24	CALM2	Calmodulin-2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.765
P40926	MDH2	Malate dehydrogenase, mitochondrial	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.718
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P0DP24	CALM2	Calmodulin-2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q15831	STK11	Serine/threonine-protein kinase STK11	0.731
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P0DP24	CALM2	Calmodulin-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.844
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.902
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P13612	ITGA4	Integrin alpha-4	0.77
P0DP24	CALM2	Calmodulin-2	P16144	ITGB4	Integrin beta-4	-0.725
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	O15335	CHAD	Chondroadherin	-0.729
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O15335	CHAD	Chondroadherin	-0.704
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q13751	LAMB3	Laminin subunit beta-3	-0.794
P40926	MDH2	Malate dehydrogenase, mitochondrial	P22105	TNXB	Tenascin-X	0.802
P60660	MYL6	Myosin light polypeptide 6	P48551	IFNAR2	Interferon alpha/beta receptor 2	0.746
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
P0DP24	CALM2	Calmodulin-2	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.801
P0DP24	CALM2	Calmodulin-2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.738
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P60660	MYL6	Myosin light polypeptide 6	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.729
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P0DP24	CALM2	Calmodulin-2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.708
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P60660	MYL6	Myosin light polypeptide 6	Q16513	PKN2	Serine/threonine-protein kinase N2	-0.748
P0DP24	CALM2	Calmodulin-2	Q6ZUJ8	PIK3AP1	Phosphoinositide 3-kinase adapter protein 1	0.859
P40926	MDH2	Malate dehydrogenase, mitochondrial	O95988	TCL1B	T-cell leukemia/lymphoma protein 1B	0.719

Bepridil

hsa04210

Apoptosis

7.52E-04

O76075, P07384, P01375, Q9NR28, Q16548, P60709, P63261

DFFB, CAPN1, TNF, DIABLO, BCL2A1, ACTB, ACTG1

Bepridil

hsa04213

Longevity regulating pathway - multiple species

2.85E-02

Q9Y4H2, Q13547

IRS2, HDAC1

Bepridil

hsa04217

Necroptosis

3.83E-11

P01375, P01568, P23458, P48023, Q13489, Q9NQC7, P42224, Q14765, P08238, P01584, P0C0S5, Q6FI13, Q99878, Q93077, P10415, Q13557, Q9H444, O43633, Q9NZZ3, O75351, Q08752

TNF, IFNA21, JAK1, FASLG, BIRC3, CYLD, STAT1, STAT4, HSP90AB1, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CAMK2D, CHMP4B, CHMP2A, CHMP5, VPS4B, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P0DP25	CALM3	Calmodulin-3	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP23	CALM1	Calmodulin-1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.822
P0DP24	CALM2	Calmodulin-2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.738
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P0DP23	CALM1	Calmodulin-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P0DP25	CALM3	Calmodulin-3	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP24	CALM2	Calmodulin-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP23	CALM1	Calmodulin-1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.883
P0DP24	CALM2	Calmodulin-2	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.778
P0DP23	CALM1	Calmodulin-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P0DP25	CALM3	Calmodulin-3	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP24	CALM2	Calmodulin-2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P0DP23	CALM1	Calmodulin-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P09960	LTA4H	Leukotriene A-4 hydrolase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.737
P0DP25	CALM3	Calmodulin-3	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP24	CALM2	Calmodulin-2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP24	CALM2	Calmodulin-2	P01584	IL1B	Interleukin-1 beta	0.72
P0DP24	CALM2	Calmodulin-2	P0C0S5	H2AFZ	Histone H2A.Z	0.749
P0DP23	CALM1	Calmodulin-1	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.81
P09960	LTA4H	Leukotriene A-4 hydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.702
P0DP25	CALM3	Calmodulin-3	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.81
P0DP24	CALM2	Calmodulin-2	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.81
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P09960	LTA4H	Leukotriene A-4 hydrolase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.714
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.786
P0DP23	CALM1	Calmodulin-1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.73
P0DP24	CALM2	Calmodulin-2	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.713
P0DP23	CALM1	Calmodulin-1	O43633	CHMP2A	Charged multivesicular body protein 2a	0.842
P09960	LTA4H	Leukotriene A-4 hydrolase	O43633	CHMP2A	Charged multivesicular body protein 2a	0.815
P0DP25	CALM3	Calmodulin-3	O43633	CHMP2A	Charged multivesicular body protein 2a	0.842
P0DP24	CALM2	Calmodulin-2	O43633	CHMP2A	Charged multivesicular body protein 2a	0.842
P0DP23	CALM1	Calmodulin-1	Q9NZZ3	CHMP5	Charged multivesicular body protein 5	0.713
P0DP24	CALM2	Calmodulin-2	Q9NZZ3	CHMP5	Charged multivesicular body protein 5	0.763
P0DP23	CALM1	Calmodulin-1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.784
P09960	LTA4H	Leukotriene A-4 hydrolase	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.771

Bepridil

hsa04218

Cellular senescence

4.79E-02

P01106, O75293, P30304, P06493

MYC, GADD45B, CDC25A, CDK1

Bepridil

hsa04261

Adrenergic signaling in cardiomyocytes

4.38E-08

P09493, P07550, P63092, Q08828, P51828, P22694, P31751, Q99941, P18848, P26678, Q13362, P0DP23, Q13557, P17252, P10415, P23634

TPM1, ADRB2, GNAS, ADCY1, ADCY7, PRKACB, AKT2, CREBL1, ATF4, PLN, PPP2R5C, CALM1, CAMK2D, PRKCA, BCL2, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P09493	TPM1	Tropomyosin alpha-1 chain	-0.749
P0DP25	CALM3	Calmodulin-3	P09493	TPM1	Tropomyosin alpha-1 chain	-0.749
P0DP24	CALM2	Calmodulin-2	P09493	TPM1	Tropomyosin alpha-1 chain	-0.749
P07550	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2	Beta-2 adrenergic receptor	1
P40926	MDH2	Malate dehydrogenase, mitochondrial	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	0.736
P0DP23	CALM1	Calmodulin-1	Q08828	ADCY1	Adenylate cyclase type 1	0.725
P0DP24	CALM2	Calmodulin-2	Q08828	ADCY1	Adenylate cyclase type 1	0.711
P0DP23	CALM1	Calmodulin-1	P51828	ADCY7	Adenylate cyclase type 7	0.719
P07550	ADRB2	Beta-2 adrenergic receptor	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P07550	ADRB2	Beta-2 adrenergic receptor	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	-0.704
P0DP24	CALM2	Calmodulin-2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.708
P40926	MDH2	Malate dehydrogenase, mitochondrial	P26678	PLN	Cardiac phospholamban	-0.71
P0DP23	CALM1	Calmodulin-1	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.736
P07550	ADRB2	Beta-2 adrenergic receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.712
P0DP24	CALM2	Calmodulin-2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.765
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P0DP25	CALM3	Calmodulin-3	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P0DP23	CALM1	Calmodulin-1	1
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.749
P0DP24	CALM2	Calmodulin-2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.786
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP23	CALM1	Calmodulin-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.793
P0DP25	CALM3	Calmodulin-3	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.793
P0DP24	CALM2	Calmodulin-2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.793

Bepridil

hsa04340

Hedgehog signaling pathway

3.32E-02

P49841, P22694

GSK3B, PRKACB

Bepridil

hsa04360

Axon guidance

9.40E-05

P61073, P16333, P20827, O95631, P17252, Q13557, P42338, P23528, P19174

CXCR4, NCK1, EFNA1, NTN1, PRKCA, CAMK2D, PIK3CB, CFL1, PLCG1

Bepridil

hsa04371

Apelin signaling pathway

1.67E-06

P62873, P63218, P50151, P31751, Q08828, P51828, Q13370, Q14814, Q14344, Q13485, P84022, P0DP23

GNB1, GNG5, GNG10, AKT2, ADCY1, ADCY7, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P0DP23	CALM1	Calmodulin-1	Q08828	ADCY1	Adenylate cyclase type 1	0.725
P0DP23	CALM1	Calmodulin-1	P51828	ADCY7	Adenylate cyclase type 7	0.719
P0DP23	CALM1	Calmodulin-1	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.761
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.767
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.826
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	-0.773
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.735
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
P0DP23	CALM1	Calmodulin-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.777
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775

Bepridil

hsa04380

Osteoclast differentiation

4.18E-02

Q9NQC7, Q9UQC2, P23458, P42224, P01584, Q15080, P14598

CYLD, GAB2, JAK1, STAT1, IL1B, NCF4, NCF1

Bepridil

hsa04390

Hippo signaling pathway

2.80E-02

P60709, P63261

ACTB, ACTG1

Bepridil

hsa04510

Focal adhesion

3.76E-02

P16144, O75369, Q15942, P17252, Q13489, P10415, P49767

ITGB4, FLNB, ZYX, PRKCA, BIRC3, BCL2, VEGFC

Bepridil

hsa04512

ECM-receptor interaction

4.41E-02

Q13751, P13612, O15335

LAMB3, ITGA4, CHAD

Bepridil

hsa04520

Adherens junction

1.58E-02

P60709, P63261

ACTB, ACTG1

Bepridil

hsa04530

Tight junction

6.83E-04

P60709, P63261, P16989, P56750, Q14247, P60660

ACTB, ACTG1, CSDA, CLDN17, CTTN, MYL6

Bepridil

hsa04540

Gap junction

1.61E-03

P17252, Q13509, P68371, Q08828, P51828, Q71U36, Q9NRA1

PRKCA, TUBB3, TUBB2C, ADCY1, ADCY7, TUBA1A, PDGFC

Bepridil

hsa04611

Platelet activation

2.98E-03

P25116, P08514, P60709, P63261, P07359

F2R, ITGA2B, ACTB, ACTG1, GP1BA

Bepridil

hsa04612

Antigen processing and presentation

1.07E-03

Q14953, P26715, P26717, Q13241, P01732, P01375

KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Bepridil

hsa04613

Neutrophil extracellular trap formation

5.42E-06

P42338, P19174, P11215, Q13547, P04908, Q93077, P58876, P62807, Q93079, Q16778, O60814, P68431, P21796, P14598, O43315, Q16539

PIK3CB, PLCG1, ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, VDAC1, NCF1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11215	ITGAM	Integrin alpha-M	-0.877
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.72
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Bepridil

hsa04620

Toll-like receptor signaling pathway

1.41E-03

P51617, P01568, P31751, P42224, P25963, P42338, Q8NHW4

IRAK1, IFNA21, AKT2, STAT1, NFKBIA, PIK3CB, CCL4L2

Bepridil

hsa04621

NOD-like receptor signaling pathway

3.16E-02

P01584, P08238, P23458, P42224, P01568, Q9H3M7, Q13489, P43490, P10415

IL1B, HSP90AB1, JAK1, STAT1, IFNA21, TXNIP, BIRC3, PBEF1, BCL2

Bepridil

hsa04623

Cytosolic DNA-sensing pathway

1.70E-05

P01568, P25963, Q8NHW4

IFNA21, NFKBIA, CCL4L2

Bepridil

hsa04625

C-type lectin receptor signaling pathway

2.17E-02

Q9ULY5, P42224, P25963, P42338, P0DP23

CLEC4E, STAT1, NFKBIA, PIK3CB, CALM1

Bepridil

hsa04630

JAK-STAT signaling pathway

1.16E-02

P31751, P10415, P42224, P23458, P14784, P16871, Q13651, P01568

AKT2, BCL2, STAT1, JAK1, IL2RB, IL7R, IL10RA, IFNA21

Bepridil

hsa04640

Hematopoietic cell lineage

4.98E-04

P08514, P21926, P07766, P01730, P09564

ITGA2B, CD9, CD3E, CD4, CD7

Bepridil

hsa04650

Natural killer cell mediated cytotoxicity

5.05E-04

P01375, P20963, Q13241, P26718, P26717, Q14953, P26715

TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1

Bepridil

hsa04657

IL-17 signaling pathway

2.10E-03

P49841, P19875, P14780, P80188, P01375

GSK3B, CXCL2, MMP9, LCN2, TNF

Bepridil

hsa04658

Th1 and Th2 cell differentiation

8.74E-03

P25963, P07766, P19174, P42224, P14784, Q13761

NFKBIA, CD3E, PLCG1, STAT1, IL2RB, RUNX3

Bepridil

hsa04659

Th17 cell differentiation

8.81E-04

P25963, P19174, P42224, P14784, P84022, P08238, P07766

NFKBIA, PLCG1, STAT1, IL2RB, SMAD3, HSP90AB1, CD3E

Bepridil

hsa04662

B cell receptor signaling pathway

1.46E-03

P25963, P42338, P20023, P07948, P21854, Q8N149

NFKBIA, PIK3CB, CR2, LYN, CD72, LILRA2

Bepridil

hsa04664

Fc epsilon RI signaling pathway

2.35E-04

P04141, P42338, P07948, P19174, P09917

CSF2, PIK3CB, LYN, PLCG1, ALOX5

Bepridil

hsa04666

Fc gamma R-mediated phagocytosis

2.54E-03

P07948, P08575, P42338, P19174, P23528, Q9UQC2, P14598, P17252

LYN, PTPRC, PIK3CB, PLCG1, CFL1, GAB2, NCF1, PRKCA

Bepridil

hsa04668

TNF signaling pathway

3.55E-02

P01375, P18848, P19875, P14780

TNF, ATF4, CXCL2, MMP9

Bepridil

hsa04670

Leukocyte transendothelial migration

4.07E-02

P60709, P63261

ACTB, ACTG1

Bepridil

hsa04672

Intestinal immune network for IgA production

1.35E-02

P29965, P13765

CD40LG, HLA-DOB

Bepridil

hsa04713

Circadian entrainment

4.99E-07

O15399, P0DP23, Q13557, P17252, P62873, P63218, P50151, Q08828, P51828

GRIN2D, CALM1, CAMK2D, PRKCA, GNB1, GNG5, GNG10, ADCY1, ADCY7

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.764
P0DP25	CALM3	Calmodulin-3	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.764
P0DP24	CALM2	Calmodulin-2	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.764
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P0DP25	CALM3	Calmodulin-3	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.786
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P0DP25	CALM3	Calmodulin-3	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP24	CALM2	Calmodulin-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P0DP23	CALM1	Calmodulin-1	Q08828	ADCY1	Adenylate cyclase type 1	0.725
P0DP24	CALM2	Calmodulin-2	Q08828	ADCY1	Adenylate cyclase type 1	0.711
P0DP23	CALM1	Calmodulin-1	P51828	ADCY7	Adenylate cyclase type 7	0.719

Bepridil

hsa04714

Thermogenesis

3.66E-05

Q16539, P15336, P60709, P63261, P33121, Q16718, O14521, P36542

MAPK14, ATF2, ACTB, ACTG1, ACSL1, NDUFA5, SDHD, ATP5C1

Bepridil

hsa04720

Long-term potentiation

3.26E-03

P17252, Q13557, P0DP23, P18848, O15399, Q08828

PRKCA, CAMK2D, CALM1, ATF4, GRIN2D, ADCY1

Bepridil

hsa04721

Synaptic vesicle cycle

3.15E-02

Q13488, P31645

TCIRG1, SLC6A4

Bepridil

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Bepridil

hsa04724

Glutamatergic synapse

9.20E-07

P48058, O15399, Q08828, P51828, P17252, P62873, P63218, P50151, P15104

GRIA4, GRIN2D, ADCY1, ADCY7, PRKCA, GNB1, GNG5, GNG10, GLUL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24844	MYL9	Myosin regulatory light polypeptide 9	P48058	GRIA4	Glutamate receptor 4	-0.771
P0DP23	CALM1	Calmodulin-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.764
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.707
P0DP23	CALM1	Calmodulin-1	Q08828	ADCY1	Adenylate cyclase type 1	0.725
P0DP23	CALM1	Calmodulin-1	P51828	ADCY7	Adenylate cyclase type 7	0.719
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.844
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.902
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P15104	GLUL	Glutamine synthetase	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P15104	GLUL	Glutamine synthetase	-0.859
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P15104	GLUL	Glutamine synthetase	-0.773
P24844	MYL9	Myosin regulatory light polypeptide 9	P15104	GLUL	Glutamine synthetase	-0.718

Bepridil

hsa04725

Cholinergic synapse

3.93E-05

Q08828, P51828, P17252, P62873, P63218, P50151, P18848, Q13557, P42338, P31751, P10415

ADCY1, ADCY7, PRKCA, GNB1, GNG5, GNG10, ATF4, CAMK2D, PIK3CB, AKT2, BCL2

Bepridil

hsa04726

Serotonergic synapse

3.80E-02

P62873, P63218, P50151, P09917

GNB1, GNG5, GNG10, ALOX5

Bepridil

hsa04727

GABAergic synapse

1.73E-06

Q08828, P51828, P62873, P63218, P50151, P15104, P46459, P17252

ADCY1, ADCY7, GNB1, GNG5, GNG10, GLUL, NSF, PRKCA

Bepridil

hsa04730

Long-term depression

3.34E-03

Q14344, P07948

GNA13, LYN

Bepridil

hsa04740

Olfactory transduction

2.61E-02

P62873, Q13557, P0DP23

GNB1, CAMK2D, CALM1

Bepridil

hsa04744

Phototransduction

3.13E-09

P62873, P0DP23

GNB1, CALM1

Bepridil

hsa04750

Inflammatory mediator regulation of TRP channels

5.49E-06

P01584, Q08828, P51828, Q13557, P19174, P42338, P17252, P24723, P0DP23, P01042

IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCA, PRKCH, CALM1, KNG1

Bepridil

hsa04810

Regulation of actin cytoskeleton

2.61E-02

P12814, Q13009, P42338, P11215, Q14344, Q9NRA1

ACTN1, TIAM1, PIK3CB, ITGAM, GNA13, PDGFC

Bepridil

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Bepridil

hsa04911

Insulin secretion

5.74E-04

Q08828, P63092, P17252, Q99941, P18848, Q13557

ADCY1, GNAS, PRKCA, CREBL1, ATF4, CAMK2D

Bepridil

hsa04912

GnRH signaling pathway

2.85E-02

P17252, Q08828, P18848, Q13557, P0DP23

PRKCA, ADCY1, ATF4, CAMK2D, CALM1

Bepridil

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Bepridil

hsa04914

Progesterone-mediated oocyte maturation

3.76E-03

Q08828, P51828, P42338, P31751, Q13370, Q9UJX4, P30304, P08238

ADCY1, ADCY7, PIK3CB, AKT2, PDE3B, ANAPC5, CDC25A, HSP90AB1

Bepridil

hsa04915

Estrogen signaling pathway

3.28E-03

P18848, Q08828, P51828, P31751, P08238, P11142, P0DP23, Q15788, P10415

ATF4, ADCY1, ADCY7, AKT2, HSP90AB1, HSPA8, CALM1, NCOA1, BCL2

Bepridil

hsa04918

Thyroid hormone synthesis

3.16E-02

P17252, P27824

PRKCA, CANX

Bepridil

hsa04919

Thyroid hormone signaling pathway

5.60E-04

P49841, P22694, P60709, P63261, O60244, Q9NVC6

GSK3B, PRKACB, ACTB, ACTG1, MED14, MED17

Bepridil

hsa04921

Oxytocin signaling pathway

1.77E-03

P60660, P60709, P63261

MYL6, ACTB, ACTG1

Bepridil

hsa04923

Regulation of lipolysis in adipocytes

2.12E-02

Q08828, P51828, Q13370, P31751

ADCY1, ADCY7, PDE3B, AKT2

Bepridil

hsa04924

Renin secretion

4.04E-02

P22694, P07550

PRKACB, ADRB2

Bepridil

hsa04925

Aldosterone synthesis and secretion

3.58E-05

Q99941, P18848, Q08828, P51828, P0DP23, P63092, P17252, Q13557, P23634

CREBL1, ATF4, ADCY1, ADCY7, CALM1, GNAS, PRKCA, CAMK2D, ATP2B4

Bepridil

hsa04926

Relaxin signaling pathway

6.11E-04

P25963, P42338, P62873, P63218, P50151, P18848, P22694, P49767, P14780, P30679

NFKBIA, PIK3CB, GNB1, GNG5, GNG10, ATF4, PRKACB, VEGFC, MMP9, GNA15

Bepridil

hsa04927

Cortisol synthesis and secretion

1.07E-03

Q99941, P18848, P63092, P22694

CREBL1, ATF4, GNAS, PRKACB

Bepridil

hsa04928

Parathyroid hormone synthesis, secretion and action

2.33E-02

P63092, P61586, Q99941, P18848

GNAS, RHOA, CREBL1, ATF4

Bepridil

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Bepridil

hsa04932

Non-alcoholic fatty liver disease

2.44E-03

P01375, P49841, P48023, Q16718, O14521

TNF, GSK3B, FASLG, NDUFA5, SDHD

Bepridil

hsa04933

AGE-RAGE signaling pathway in diabetic complications

2.04E-06

Q13485, P01584, P42224, P10415, P31751, P49767, P17252, P19174

SMAD4, IL1B, STAT1, BCL2, AKT2, VEGFC, PRKCA, PLCG1

Bepridil

hsa04934

Cushing syndrome

1.37E-03

Q99941, P18848, P63092, O15169, Q13557

CREBL1, ATF4, GNAS, AXIN1, CAMK2D

Bepridil

hsa04935

Growth hormone synthesis, secretion and action

3.93E-02

P19174, Q08828, P51828, P17252, P31751, P42224

PLCG1, ADCY1, ADCY7, PRKCA, AKT2, STAT1

Bepridil

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Bepridil

hsa04970

Salivary secretion

9.40E-05

P07550, Q08828, P51828, P22694, P23634, P17252, P0DP23, P49913

ADRB2, ADCY1, ADCY7, PRKACB, ATP2B4, PRKCA, CALM1, CAMP

Bepridil

hsa04971

Gastric acid secretion

1.02E-02

P60709, P63261

ACTB, ACTG1

Bepridil

hsa04972

Pancreatic secretion

1.92E-03

P23634, P17252, Q08828, P51828, P62491

ATP2B4, PRKCA, ADCY1, ADCY7, RAB11A

Bepridil

hsa04976

Bile secretion

1.67E-03

O43315, P22694, P08183

AQP9, PRKACB, ABCB1

Bepridil

hsa05010

Alzheimer disease

1.52E-03

Q92542, O15239, P05496, O15399, Q9NZJ5, Q13564, P18848, Q71U36, O15169, P09603, P05141, P12236, P21796, P43686, P62195

NCSTN, NDUFA1, ATP5G1, GRIN2D, EIF2AK3, APPBP1, ATF4, TUBA1A, AXIN1, CSF1, SLC25A5, SLC25A6, VDAC1, PSMC4, PSMC5

Bepridil

hsa05012

Parkinson disease

2.75E-05

O15239, P05496, P05141, P12236, P21796, P60604, P63092, P18848, P43686, P62195, P19174, P0DP23, Q13557, Q71U36, Q13509, P68371

NDUFA1, ATP5G1, SLC25A5, SLC25A6, VDAC1, UBE2G2, GNAS, ATF4, PSMC4, PSMC5, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.747
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.718
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.725
P40926	MDH2	Malate dehydrogenase, mitochondrial	P12236	SLC25A6	ADP/ATP translocase 3	0.722
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.72
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P60604	UBE2G2	Ubiquitin-conjugating enzyme E2 G2	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P60604	UBE2G2	Ubiquitin-conjugating enzyme E2 G2	0.775
P40926	MDH2	Malate dehydrogenase, mitochondrial	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	0.736
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40926	MDH2	Malate dehydrogenase, mitochondrial	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P40926	MDH2	Malate dehydrogenase, mitochondrial	P62195	PSMC5	26S proteasome regulatory subunit 8	0.721
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.749
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.804
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.866
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13509	TUBB3	Tubulin beta-3 chain	0.777
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13509	TUBB3	Tubulin beta-3 chain	0.789
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P68371	TUBB2C	Tubulin beta-4B chain	0.741

Bepridil

hsa05014

Amyotrophic lateral sclerosis

3.85E-03

P20333, O15239, P36542, P05496, P18848, P43686, P62195, P51991, P35658, P60709, P63261

TNFRSF1B, NDUFA1, ATP5C1, ATP5G1, ATF4, PSMC4, PSMC5, HNRPA3, NUP214, ACTB, ACTG1

Bepridil

hsa05016

Huntington disease

2.46E-05

Q9GZM3, P52435, Q9NYC9

POLR2J2, POLR2J, DNAH9

Bepridil

hsa05017

Spinocerebellar ataxia

3.80E-03

P17252, O75460, Q8TB72, O15399, P31751, P28070, P43686, O00232

PRKCA, ERN1, PUM2, GRIN2D, AKT2, PSMB4, PSMC4, PSMD12

Bepridil

hsa05020

Prion disease

5.84E-04

P46531, O15239, Q16718, O14521, P05496, P18848, P05141, P12236, P43686, P62195, P49841, Q99941, Q16539

NOTCH1, NDUFA1, NDUFA5, SDHD, ATP5G1, ATF4, SLC25A5, SLC25A6, PSMC4, PSMC5, GSK3B, CREBL1, MAPK14

Bepridil

hsa05022

Pathways of neurodegeneration - multiple diseases

3.93E-04

P49841, O15239, Q16718, O14521, P05496, P18848, Q13561, P05141, P12236, P20333, Q16539, O15169, Q08752, Q13557, P43686, P62195

GSK3B, NDUFA1, NDUFA5, SDHD, ATP5G1, ATF4, DCTN2, SLC25A5, SLC25A6, TNFRSF1B, MAPK14, AXIN1, PPID, CAMK2D, PSMC4, PSMC5

Bepridil

hsa05030

Cocaine addiction

2.40E-02

P63092, Q99941, P18848

GNAS, CREBL1, ATF4

Bepridil

hsa05031

Amphetamine addiction

8.18E-05

O15399, P0DP23, Q13557, P22694, P63092, Q99941, P18848, P17252, Q13547

GRIN2D, CALM1, CAMK2D, PRKACB, GNAS, CREBL1, ATF4, PRKCA, HDAC1

Bepridil

hsa05032

Morphine addiction

3.37E-06

Q08828, P51828, P62873, P63218, P50151, Q13370, Q07343, P17252, P43250

ADCY1, ADCY7, GNB1, GNG5, GNG10, PDE3B, PDE4B, PRKCA, GRK6

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	Q08828	ADCY1	Adenylate cyclase type 1	0.725
P0DP23	CALM1	Calmodulin-1	P51828	ADCY7	Adenylate cyclase type 7	0.719
P0DP23	CALM1	Calmodulin-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.844
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.902
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P0DP23	CALM1	Calmodulin-1	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.761
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.767
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.826
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q07343	PDE4B	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	-0.7
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P43250	GRK6	G protein-coupled receptor kinase 6	-0.747
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P43250	GRK6	G protein-coupled receptor kinase 6	-0.775

Bepridil

hsa05034

Alcoholism

1.63E-06

Q13547, P0DP23, P62873, P63218, P50151, Q93077, P58876, P62807, Q93079, Q16778, O60814, P68431

HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, H2BC5, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Bepridil

hsa05100

Bacterial invasion of epithelial cells

8.79E-04

P60709, P63261, Q92529

ACTB, ACTG1, SHC3

Bepridil

hsa05110

Vibrio cholerae infection

3.56E-04

Q99437, P60709, P63261

ATP6V0B, ACTB, ACTG1

Bepridil

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

1.08E-02

P25963, Q13488, P19174, P07948

NFKBIA, TCIRG1, PLCG1, LYN

Bepridil

hsa05130

Pathogenic Escherichia coli infection

3.19E-02

Q71U36, P16333, Q13509, P68371, Q14344, P25963

TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIA

Bepridil

hsa05131

Shigellosis

1.91E-02

P60709, P63261, P07384

ACTB, ACTG1, CAPN1

Bepridil

hsa05132

Salmonella infection

4.11E-06

P51617, P01584, P25963, P08238, P01106, P42338, Q96RF0, Q13489, P10415, P08575, O75369, Q13561, Q71U36, Q13509, P68371, P49754, Q9NP90

IRAK1, IL1B, NFKBIA, HSP90AB1, MYC, PIK3CB, SNAG1, BIRC3, BCL2, PTPRC, FLNB, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41, RAB9B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP25	CALM3	Calmodulin-3	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P01584	IL1B	Interleukin-1 beta	0.72
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P0DP25	CALM3	Calmodulin-3	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP24	CALM2	Calmodulin-2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P0DP24	CALM2	Calmodulin-2	Q96RF0	SNAG1	Sorting nexin-18	0.703
P0DP25	CALM3	Calmodulin-3	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP24	CALM2	Calmodulin-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P08575	PTPRC	Receptor-type tyrosine-protein phosphatase C	0.716
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75369	FLNB	Filamin-B	0.769
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75369	FLNB	Filamin-B	0.706
P0DP25	CALM3	Calmodulin-3	O75369	FLNB	Filamin-B	0.874
P0DP24	CALM2	Calmodulin-2	O75369	FLNB	Filamin-B	0.874
P0DP25	CALM3	Calmodulin-3	Q13561	DCTN2	Dynactin subunit 2	0.739
P0DP24	CALM2	Calmodulin-2	Q13561	DCTN2	Dynactin subunit 2	0.739
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.804
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.866
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13509	TUBB3	Tubulin beta-3 chain	0.777
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13509	TUBB3	Tubulin beta-3 chain	0.789
P0DP25	CALM3	Calmodulin-3	Q13509	TUBB3	Tubulin beta-3 chain	0.892
P0DP24	CALM2	Calmodulin-2	Q13509	TUBB3	Tubulin beta-3 chain	0.892
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P68371	TUBB2C	Tubulin beta-4B chain	0.741
P0DP25	CALM3	Calmodulin-3	P68371	TUBB2C	Tubulin beta-4B chain	0.742
P0DP24	CALM2	Calmodulin-2	P68371	TUBB2C	Tubulin beta-4B chain	0.742
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.807
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.728
P0DP25	CALM3	Calmodulin-3	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.723
P0DP24	CALM2	Calmodulin-2	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.723
P0DP24	CALM2	Calmodulin-2	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.791

Bepridil

hsa05133

Pertussis

3.94E-04

P0DP23, P01584, P23528, P09871, P51617

CALM1, IL1B, CFL1, C1S, IRAK1

Bepridil

hsa05134

Legionellosis

4.75E-02

P25963, P11215, P11142

NFKBIA, ITGAM, HSPA8

Bepridil

hsa05135

Yersinia infection

3.88E-03

P60709, P63261, Q16513

ACTB, ACTG1, PKN2

Bepridil

hsa05140

Leishmaniasis

6.92E-06

P14598, P11215, P42224, O60603, P25963, P29350, Q15080

NCF1, ITGAM, STAT1, TLR2, NFKBIA, PTPN6, NCF4

Bepridil

hsa05143

African trypanosomiasis

3.56E-03

P01375, P01584, P48023, P17252, P01042

TNF, IL1B, FASLG, PRKCA, KNG1

Bepridil

hsa05144

Malaria

1.91E-02

P01375, P35443, P26718

TNF, THBS4, KLRK1

Bepridil

hsa05145

Toxoplasmosis

5.28E-05

P51617, P10415, Q13489, P23458, P42224, P31751, P11142, P29965, Q13651

IRAK1, BCL2, BIRC3, JAK1, STAT1, AKT2, HSPA8, CD40LG, IL10RA

Bepridil

hsa05146

Amoebiasis

2.41E-02

P19875, P01375, P30679, P22694

CXCL2, TNF, GNA15, PRKACB

Bepridil

hsa05150

Staphylococcus aureus infection

1.91E-02

Q14532, P59665, P59666, P49913

KRT32, DEFA1; DEFA1B, DEFA3, CAMP

Bepridil

hsa05152

Tuberculosis

4.16E-02

Q99437, P25774

ATP6V0B, CTSS

Bepridil

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Bepridil

hsa05161

Hepatitis B

1.31E-04

P17252, P18848, P23458, Q13485, P31751, P10415, P27348, P01568, P42224, P51617

PRKCA, ATF4, JAK1, SMAD4, AKT2, BCL2, YWHAQ, IFNA21, STAT1, IRAK1

Bepridil

hsa05162

Measles

1.12E-05

P51617, P01568, P25963, P23458, P42224, P14784, P07766, P42338, P31751, P11142, P01584, Q9NP90, P10415

IRAK1, IFNA21, NFKBIA, JAK1, STAT1, IL2RB, CD3E, PIK3CB, AKT2, HSPA8, IL1B, RAB9B, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP25	CALM3	Calmodulin-3	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P0DP25	CALM3	Calmodulin-3	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P0DP23	CALM1	Calmodulin-1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.822
P0DP24	CALM2	Calmodulin-2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.738
P0DP23	CALM1	Calmodulin-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P0DP25	CALM3	Calmodulin-3	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP24	CALM2	Calmodulin-2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP23	CALM1	Calmodulin-1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.801
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
P0DP25	CALM3	Calmodulin-3	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.801
P0DP24	CALM2	Calmodulin-2	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.801
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P0DP23	CALM1	Calmodulin-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.804
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.928
P0DP25	CALM3	Calmodulin-3	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.804
P0DP24	CALM2	Calmodulin-2	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.804
P0DP24	CALM2	Calmodulin-2	P01584	IL1B	Interleukin-1 beta	0.72
P0DP24	CALM2	Calmodulin-2	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.791
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772

Bepridil

hsa05163

Human cytomegalovirus infection

2.61E-07

P31751, P42338, P25963, P62873, P63218, P50151, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P01106, P01584, P61073, P17252, Q13651, P18848, P30101, P61769, P01568

AKT2, PIK3CB, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, MYC, IL1B, CXCR4, PRKCA, IL10RA, ATF4, PDIA3, B2M, IFNA21

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P0DP23	CALM1	Calmodulin-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P0DP24	CALM2	Calmodulin-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P0DP24	CALM2	Calmodulin-2	P0DP23	CALM1	Calmodulin-1	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.735
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
P0DP23	CALM1	Calmodulin-1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.729
P0DP23	CALM1	Calmodulin-1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.729
P0DP23	CALM1	Calmodulin-1	Q08828	ADCY1	Adenylate cyclase type 1	0.725
P0DP24	CALM2	Calmodulin-2	Q08828	ADCY1	Adenylate cyclase type 1	0.711
P0DP23	CALM1	Calmodulin-1	P51828	ADCY7	Adenylate cyclase type 7	0.719
P0DP23	CALM1	Calmodulin-1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.822
P0DP24	CALM2	Calmodulin-2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.738
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P0DP24	CALM2	Calmodulin-2	P01584	IL1B	Interleukin-1 beta	0.72
P0DP24	CALM2	Calmodulin-2	P61073	CXCR4	C-X-C chemokine receptor type 4	0.759
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.701
P0DP24	CALM2	Calmodulin-2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.708
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
P0DP24	CALM2	Calmodulin-2	P61769	B2M	Beta-2-microglobulin	0.787
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852

Bepridil

hsa05164

Influenza A

7.10E-03

P48551, P60709, P63261

IFNAR2, ACTB, ACTG1

Bepridil

hsa05167

Kaposi sarcoma-associated herpesvirus infection

2.44E-08

P01568, P42224, P25963, P42338, P62873, P63218, P50151, P19174, P07948, P01106, P04141, P0DP23

IFNA21, STAT1, NFKBIA, PIK3CB, GNB1, GNG5, GNG10, PLCG1, LYN, MYC, CSF2, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P04141	CSF2	Granulocyte-macrophage colony-stimulating factor	-0.79
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775

Bepridil

hsa05168

Herpes simplex virus 1 infection

2.15E-09

P25963, P01568, P01584, Q05823, Q9UBU9, P23458, P42224, Q07955, Q01130, Q13243, Q13489, P51617, P30101, P61769, P31751, P42338, Q9Y2A4, Q13398, P51522, Q9HCX3, Q6P280, P17038, Q03923, P52738, O75820, Q9UDV6, P10415, Q14232

NFKBIA, IFNA21, IL1B, RNASEL, NXF1, JAK1, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, IRAK1, PDIA3, B2M, AKT2, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF304, ZNF529, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212, BCL2, EIF2B1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.825
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P0DP25	CALM3	Calmodulin-3	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01584	IL1B	Interleukin-1 beta	0.72
P09960	LTA4H	Leukotriene A-4 hydrolase	Q05823	RNASEL	2-5A-dependent ribonuclease	0.752
P0DP23	CALM1	Calmodulin-1	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.743
P0DP24	CALM2	Calmodulin-2	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.772
P0DP23	CALM1	Calmodulin-1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.822
P0DP24	CALM2	Calmodulin-2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.738
P0DP23	CALM1	Calmodulin-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P0DP25	CALM3	Calmodulin-3	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP24	CALM2	Calmodulin-2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP23	CALM1	Calmodulin-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.866
P09960	LTA4H	Leukotriene A-4 hydrolase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.732
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.827
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.703
P0DP25	CALM3	Calmodulin-3	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P0DP24	CALM2	Calmodulin-2	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P0DP23	CALM1	Calmodulin-1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.835
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.783
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.781
P0DP25	CALM3	Calmodulin-3	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P0DP24	CALM2	Calmodulin-2	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P0DP23	CALM1	Calmodulin-1	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.908
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.819
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.943
P0DP25	CALM3	Calmodulin-3	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP24	CALM2	Calmodulin-2	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP23	CALM1	Calmodulin-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P0DP25	CALM3	Calmodulin-3	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP24	CALM2	Calmodulin-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP23	CALM1	Calmodulin-1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP25	CALM3	Calmodulin-3	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
P0DP24	CALM2	Calmodulin-2	P61769	B2M	Beta-2-microglobulin	0.787
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q9Y2A4	ZNF443	Zinc finger protein 443	0.731
P0DP23	CALM1	Calmodulin-1	Q13398	ZNF211	Zinc finger protein 211	0.898
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13398	ZNF211	Zinc finger protein 211	0.891
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13398	ZNF211	Zinc finger protein 211	0.729
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13398	ZNF211	Zinc finger protein 211	0.849
P0DP25	CALM3	Calmodulin-3	Q13398	ZNF211	Zinc finger protein 211	0.898
P0DP24	CALM2	Calmodulin-2	Q13398	ZNF211	Zinc finger protein 211	0.898
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P51522	ZNF83	Zinc finger protein 83	0.851
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9HCX3	ZNF304	Zinc finger protein 304	-0.746
P0DP23	CALM1	Calmodulin-1	Q6P280	ZNF529	Zinc finger protein 529	0.767
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P17038	ZNF43	Zinc finger protein 43	0.718
P0DP23	CALM1	Calmodulin-1	Q03923	ZNF85	Zinc finger protein 85	-0.818
P0DP25	CALM3	Calmodulin-3	Q03923	ZNF85	Zinc finger protein 85	-0.818
P0DP24	CALM2	Calmodulin-2	Q03923	ZNF85	Zinc finger protein 85	-0.818
P09960	LTA4H	Leukotriene A-4 hydrolase	P52738	ZNF140	Zinc finger protein 140	-0.724
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P52738	ZNF140	Zinc finger protein 140	0.71
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75820	ZNF189	Zinc finger protein 189	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	O75820	ZNF189	Zinc finger protein 189	-0.722
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75820	ZNF189	Zinc finger protein 189	-0.766
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	O75820	ZNF189	Zinc finger protein 189	0.768
P0DP23	CALM1	Calmodulin-1	Q9UDV6	ZNF212	Zinc finger protein 212	0.759
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9UDV6	ZNF212	Zinc finger protein 212	0.824
P0DP25	CALM3	Calmodulin-3	Q9UDV6	ZNF212	Zinc finger protein 212	0.759
P0DP24	CALM2	Calmodulin-2	Q9UDV6	ZNF212	Zinc finger protein 212	0.759
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP23	CALM1	Calmodulin-1	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.797

Bepridil

hsa05169

Epstein-Barr virus infection

1.08E-03

P01106, Q13547, P25963, P42338, P07948, P30101, Q13761, O75293, P42224, P01568, P07766

MYC, HDAC1, NFKBIA, PIK3CB, LYN, PDIA3, RUNX3, GADD45B, STAT1, IFNA21, CD3E

Bepridil

hsa05170

Human immunodeficiency virus 1 infection

3.08E-08

P31751, P42338, P62873, P63218, P50151, P0DP23, P61073, P17252, P30101, P61769, P01568, P51617, P25963, P19174, P23528, P07766, P10415, Q9Y6Q5

AKT2, PIK3CB, GNB1, GNG5, GNG10, CALM1, CXCR4, PRKCA, PDIA3, B2M, IFNA21, IRAK1, NFKBIA, PLCG1, CFL1, CD3E, BCL2, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P0DP23	CALM1	Calmodulin-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P0DP25	CALM3	Calmodulin-3	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP24	CALM2	Calmodulin-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P0DP25	CALM3	Calmodulin-3	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P61073	CXCR4	C-X-C chemokine receptor type 4	0.759
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
P0DP24	CALM2	Calmodulin-2	P61769	B2M	Beta-2-microglobulin	0.787
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P0DP25	CALM3	Calmodulin-3	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP23	CALM1	Calmodulin-1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP25	CALM3	Calmodulin-3	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P0DP25	CALM3	Calmodulin-3	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP23	CALM1	Calmodulin-1	P23528	CFL1	Cofilin-1	-0.832
P0DP25	CALM3	Calmodulin-3	P23528	CFL1	Cofilin-1	-0.832
P0DP24	CALM2	Calmodulin-2	P23528	CFL1	Cofilin-1	-0.832
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP23	CALM1	Calmodulin-1	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.742
P0DP25	CALM3	Calmodulin-3	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.742
P0DP24	CALM2	Calmodulin-2	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.742

Bepridil

hsa05200

Pathways in cancer

3.44E-13

P42338, P23458, P08238, P42224, P25963, P19174, Q15311, P01106, P17252, P43246, P84022, Q13485, P20585, Q13547, P14923, P10415, Q13489, P49767, P31751, Q08828, P51828, P62873, P63218, P50151, Q14344, P61073, P78417, O75293, Q15788, P0DP23, Q13557, O43521, P01568, P14784, P16871, P00734, P01042

PIK3CB, JAK1, HSP90AB1, STAT1, NFKBIA, PLCG1, RALBP1, MYC, PRKCA, MSH2, SMAD3, SMAD4, MSH3, HDAC1, JUP, BCL2, BIRC3, VEGFC, AKT2, ADCY1, ADCY7, GNB1, GNG5, GNG10, GNA13, CXCR4, GSTO1, GADD45B, NCOA1, CALM1, CAMK2D, BCL2L11, IFNA21, IL2RB, IL7R, F2, KNG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P0DP23	CALM1	Calmodulin-1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.822
P0DP24	CALM2	Calmodulin-2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.738
P0DP23	CALM1	Calmodulin-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P0DP25	CALM3	Calmodulin-3	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP24	CALM2	Calmodulin-2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP23	CALM1	Calmodulin-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P0DP25	CALM3	Calmodulin-3	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP24	CALM2	Calmodulin-2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P0DP25	CALM3	Calmodulin-3	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP23	CALM1	Calmodulin-1	Q15311	RALBP1	RalA-binding protein 1	0.858
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	P43246	MSH2	DNA mismatch repair protein Msh2	0.944
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P43246	MSH2	DNA mismatch repair protein Msh2	0.887
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P43246	MSH2	DNA mismatch repair protein Msh2	0.816
P0DP25	CALM3	Calmodulin-3	P43246	MSH2	DNA mismatch repair protein Msh2	0.944
P0DP24	CALM2	Calmodulin-2	P43246	MSH2	DNA mismatch repair protein Msh2	0.944
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
P0DP23	CALM1	Calmodulin-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.777
P0DP25	CALM3	Calmodulin-3	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.777
P0DP24	CALM2	Calmodulin-2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.777
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P20585	MSH3	DNA mismatch repair protein Msh3	0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P0DP23	CALM1	Calmodulin-1	P14923	JUP	Junction plakoglobin	-0.852
P0DP25	CALM3	Calmodulin-3	P14923	JUP	Junction plakoglobin	-0.852
P0DP24	CALM2	Calmodulin-2	P14923	JUP	Junction plakoglobin	-0.852
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP23	CALM1	Calmodulin-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP25	CALM3	Calmodulin-3	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP24	CALM2	Calmodulin-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP23	CALM1	Calmodulin-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P0DP25	CALM3	Calmodulin-3	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP24	CALM2	Calmodulin-2	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P0DP23	CALM1	Calmodulin-1	Q08828	ADCY1	Adenylate cyclase type 1	0.725
P0DP24	CALM2	Calmodulin-2	Q08828	ADCY1	Adenylate cyclase type 1	0.711
P0DP23	CALM1	Calmodulin-1	P51828	ADCY7	Adenylate cyclase type 7	0.719
P0DP23	CALM1	Calmodulin-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P0DP25	CALM3	Calmodulin-3	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP24	CALM2	Calmodulin-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.735
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
P0DP24	CALM2	Calmodulin-2	P61073	CXCR4	C-X-C chemokine receptor type 4	0.759
P0DP23	CALM1	Calmodulin-1	P78417	GSTO1	Glutathione S-transferase omega-1	-0.804
P0DP25	CALM3	Calmodulin-3	P78417	GSTO1	Glutathione S-transferase omega-1	-0.804
P0DP24	CALM2	Calmodulin-2	P78417	GSTO1	Glutathione S-transferase omega-1	-0.804
P0DP23	CALM1	Calmodulin-1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.847
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.742
P0DP25	CALM3	Calmodulin-3	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853
P0DP24	CALM2	Calmodulin-2	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853
P0DP24	CALM2	Calmodulin-2	Q15788	NCOA1	Nuclear receptor coactivator 1	0.731
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P0DP25	CALM3	Calmodulin-3	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.786
P0DP24	CALM2	Calmodulin-2	O43521	BCL2L11	Bcl-2-like protein 11	0.75
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P0DP25	CALM3	Calmodulin-3	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP23	CALM1	Calmodulin-1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.801
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
P0DP25	CALM3	Calmodulin-3	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.801
P0DP24	CALM2	Calmodulin-2	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.801
P0DP23	CALM1	Calmodulin-1	P16871	IL7R	Interleukin-7 receptor subunit alpha	0.718
P0DP23	CALM1	Calmodulin-1	P00734	F2	Prothrombin	-0.738
P0DP23	CALM1	Calmodulin-1	P01042	KNG1	Kininogen-1	-0.71
P0DP25	CALM3	Calmodulin-3	P01042	KNG1	Kininogen-1	-0.71
P0DP24	CALM2	Calmodulin-2	P01042	KNG1	Kininogen-1	-0.71

Bepridil

hsa05202

Transcriptional misregulation in cancer

1.24E-02

P27930, P11215, Q13547, P12980

IL1R2, ITGAM, HDAC1, LYL1

Bepridil

hsa05203

Viral carcinogenesis

1.68E-06

Q99941, P18848, P42338, P06746, P07948, P27348, P29083, Q13547, Q15283, P61586, P12814, P25963, P61978, P58876, P62807, Q93079, Q16778, O60814

CREBL1, ATF4, PIK3CB, POLB, LYN, YWHAQ, GTF2E1, HDAC1, RASA2, RHOA, ACTN1, NFKBIA, HNRPK, H2BC5, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P06746	POLB	DNA polymerase beta	0.837
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P40926	MDH2	Malate dehydrogenase, mitochondrial	P27348	YWHAQ	14-3-3 protein theta	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P29083	GTF2E1	General transcription factor IIE subunit 1	0.786
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q15283	RASA2	Ras GTPase-activating protein 2	-0.815
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61586	RHOA	Transforming protein RhoA	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P12814	ACTN1	Alpha-actinin-1	-0.729
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.878
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728

Bepridil

hsa05204

Chemical carcinogenesis

2.59E-04

P00325, P78417, P11712, P33260

ADH1B, GSTO1, CYP2C9, CYP2C18

Bepridil

hsa05205

Proteoglycans in cancer

4.46E-03

Q12955, Q14247, P14780, P17252, P01375, P23588, Q13635, P22694, P08962

ANK3, CTTN, MMP9, PRKCA, TNF, EIF4B, PTCH1, PRKACB, CD63

Bepridil

hsa05206

MicroRNAs in cancer

2.77E-04

P30304, P09493, P15311, P21860, P01106, P42338, P61978, P46531, Q13547, P63279, P22105, P61586, P20827, P19174

CDC25A, TPM1, VIL2, ERBB3, MYC, PIK3CB, HNRPK, NOTCH1, HDAC1, UBE2I, TNXB, RHOA, EFNA1, PLCG1

Bepridil

hsa05212

Pancreatic cancer

6.61E-04

P31751, Q15311, P23458, P42224, P84022, Q13485, O75293

AKT2, RALBP1, JAK1, STAT1, SMAD3, SMAD4, GADD45B

Bepridil

hsa05214

Glioma

1.07E-07

P0DP23, Q13557, P17252, P42338, P31751, P19174, O75293

CALM1, CAMK2D, PRKCA, PIK3CB, AKT2, PLCG1, GADD45B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P0DP25	CALM3	Calmodulin-3	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.786
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P0DP25	CALM3	Calmodulin-3	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP23	CALM1	Calmodulin-1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.847
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.742
P0DP25	CALM3	Calmodulin-3	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853
P0DP24	CALM2	Calmodulin-2	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853

Bepridil

hsa05216

Thyroid cancer

3.80E-02

P01106, O75293

MYC, GADD45B

Bepridil

hsa05218

Melanoma

2.31E-02

Q9NRA1, P42338, O75293

PDGFC, PIK3CB, GADD45B

Bepridil

hsa05220

Chronic myeloid leukemia

2.17E-02

Q13547, P01106, P25963, P42338, O75293

HDAC1, MYC, NFKBIA, PIK3CB, GADD45B

Bepridil

hsa05223

Non-small cell lung cancer

1.39E-02

P10826, Q9HC35, O75293

RARB, EML4, GADD45B

Bepridil

hsa05225

Hepatocellular carcinoma

4.07E-02

P60709, P63261

ACTB, ACTG1

Bepridil

hsa05231

Choline metabolism in cancer

2.92E-03

P42338, Q9NRA1, Q9Y259, P19174, P23743

PIK3CB, PDGFC, CHKB, PLCG1, DGKA

Bepridil

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.49E-03

P25963, P42338, P19174, P07766, P06239, P42224, Q9HC35, P01730

NFKBIA, PIK3CB, PLCG1, CD3E, LCK, STAT1, EML4, CD4

Bepridil

hsa05310

Asthma

1.35E-02

P13765, P29965

HLA-DOB, CD40LG

Bepridil

hsa05320

Autoimmune thyroid disease

3.16E-02

P13765, P29965

HLA-DOB, CD40LG

Bepridil

hsa05321

Inflammatory bowel disease

1.91E-02

P01375, Q14765, Q9UL17

TNF, STAT4, TBX21

Bepridil

hsa05322

Systemic lupus erythematosus

4.80E-06

P09871, Q93077, P58876, P62807, Q16778, O60814, P68431

C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Bepridil

hsa05323

Rheumatoid arthritis

2.00E-02

Q13488, P10747, O60603

TCIRG1, CD28, TLR2

Bepridil

hsa05330

Allograft rejection

1.76E-03

P13765, P29965, P48023, P01375

HLA-DOB, CD40LG, FASLG, TNF

Bepridil

hsa05332

Graft-versus-host disease

7.27E-04

P48023, P01375, P26715, Q13241

FASLG, TNF, KLRC1, KLRD1

Bepridil

hsa05340

Primary immunodeficiency

8.85E-05

P01730, P11912, P07766, P06239

CD4, CD79A, CD3E, LCK

Bepridil

hsa05410

Hypertrophic cardiomyopathy

1.02E-02

P60709, P63261

ACTB, ACTG1

Bepridil

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.17E-04

P14923, P08514, P60709, P63261, Q9UJU2

JUP, ITGA2B, ACTB, ACTG1, LEF1

Bepridil

hsa05414

Dilated cardiomyopathy

1.73E-02

P60709, P63261

ACTB, ACTG1

Bepridil

hsa05415

Diabetic cardiomyopathy

2.48E-05

P17252, P05141, P12236, P14598, Q15080, O15239, Q16718, O14521, P05496, Q16539, P49841, Q13557, P04406, P26678

PRKCA, SLC25A5, SLC25A6, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, ATP5G1, MAPK14, GSK3B, CAMK2D, GAPDH, PLN

Bepridil

hsa05416

Viral myocarditis

1.79E-03

P13765, P29965, P60709, P63261

HLA-DOB, CD40LG, ACTB, ACTG1

Bepridil

hsa05418

Fluid shear stress and atherosclerosis

3.64E-03

P14598, P78417, P60709, P63261, P10415, P0DP23, P08238, Q92974

NCF1, GSTO1, ACTB, ACTG1, BCL2, CALM1, HSP90AB1, ARHGEF2

Community members of Bepridil (S_DC: 5.16)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

CALM1

CalmodulinNone1

Reported

0.4552

0.1479

1.5235

P61088

UBE2N

UbiquitinNoneconjugating enzyme E2 N

Predicted

0.1102

0.3825

0.3736

1.1937

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P52732

KIF11

KinesinNonelike protein KIF11

Predicted

0.0082

0.8281

1.6602

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P25774

CTSS

Cathepsin S

Predicted

0.3185

0.4932

0.5168

1.6625

O15245

SLC22A1

Solute carrier family 22 member 1

Predicted

0.0149

0.0219

2.0294

Q13627

DYRK1A

Dual specificity tyrosineNonephosphorylationNoneregulated kinase 1A

Predicted

0.015

0.7082

1.4239

P08238

HSP90AB1

Heat shock protein HSP 90Nonebeta

Predicted

0.0611

0.5208

0.741

1.8131

P22001

KCNA3

Potassium voltageNonegated channel subfamily A member 3

Predicted

0.1396

0.5055

1.0809

P12271

RLBP1

RetinaldehydeNonebinding protein 1

Predicted

0.084

0.1062

0.2543

P08183

ABCB1

ATPNonedependent translocase ABCB1

Predicted

0.0788

0.2052

2.2446

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

P04156

PRNP

Major prion protein

Predicted

0.5909

0.1737

0.6429

P09960

LTA4H

Leukotriene ANone4 hydrolase

Predicted

0.277

0.9519

0.1565

2.1988

P25116

F2R

ProteinaseNoneactivated receptor 1

Predicted

0.2038

0.3196

0.5136

1.2547

P40926

MDH2

Malate dehydrogenase, mitochondrial

Predicted

0.4721

0.1611

0.2474

0.8055

P40925

MDH1

Malate dehydrogenase, cytoplasmic

Predicted

0.3566

0.2746

0.2426

0.97

P0DP25

CALM3

CalmodulinNone3

Predicted

0.5661

0.1479

0.5789

P0DP24

CALM2

CalmodulinNone2

Predicted

0.4376

0.1479

0.5147

P60660

MYL6

Myosin light polypeptide 6

Predicted

0.5595

0.0687

0.2175

0.6346

P24844

MYL9

Myosin regulatory light polypeptide 9

Predicted

0.0064

0.063

0.6026

0.7318

P14649

MYL6B

Myosin light chain 6B

Predicted

0.0477

0.0653

0.2175

0.3719

P05976

MYL1

Myosin light chain 1/3, skeletal muscle isoform

Predicted

0.2581

0.0619

0.2528

O15182

CETN3

CentrinNone3

Predicted

0.1872

0.0594

0.2123

Q96A32

MYLPF

Myosin regulatory light chain 2, skeletal muscle isoform

Predicted

0.0135

0.0473

0.5412

0.6425

PharmaCoNets of Bepridil (SPCN: 125.73 )

Bepridil regulated-network (SDN: 24.37)

Community members of Bepridil (SDC: 5.16)

PharmaCoNets of Bepridil (S_PCN: 125.73 )

Bepridil regulated-network (S_DN: 24.37)

Community members of Bepridil (S_DC: 5.16)