PharmaCoNets of Bepotastine (SPCN: 63.74 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Bepotastinehsa00190Oxidative phosphorylation5.12E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Bepotastinehsa00310Lysine degradation4.14E-021Q02809PLOD1More
Bepotastinehsa00500Starch and sucrose metabolism1.47E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Bepotastinehsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Bepotastinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Bepotastinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Bepotastinehsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Bepotastinehsa00630Glyoxylate and dicarboxylate metabolism2.27E-052P40925, P15104MDH1, GLULMore
Bepotastinehsa00730Thiamine metabolism4.07E-022P05186, P24666ALPL, ACP1More
Bepotastinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Bepotastinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Bepotastinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Bepotastinehsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Bepotastinehsa012102-Oxocarboxylic acid metabolism2.63E-041P50213IDH3AMore
Bepotastinehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Bepotastinehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Bepotastinehsa03020RNA polymerase9.86E-072Q9GZM3, P52435POLR2J2, POLR2JMore
Bepotastinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Bepotastinehsa03040Spliceosome8.73E-048Q14562, O43143, O60508, P08579, Q07955, Q01130, Q13243, O43447DHX8, DHX15, CDC40, SNRPB2, SFRS1, SFRS2, SFRS5, PPIHMore
Bepotastinehsa03050Proteasome4.83E-021P55036PSMD4More
Bepotastinehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Bepotastinehsa04024cAMP signaling pathway4.38E-024P42338, P0DP23, Q13370, Q13009PIK3CB, CALM1, PDE3B, TIAM1More
Bepotastinehsa04064NF-kappa B signaling pathway1.14E-0311Q13489, O00463, Q13546, P14778, Q9UDY8, Q13077, Q16548, Q8WV28, P24522, P09341, Q9UNE0BIRC3, TRAF5, RIPK1, IL1R1, MALT1, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1, EDARMore
Bepotastinehsa04070Phosphatidylinositol signaling system4.86E-023P0DP23, P42338, P27987CALM1, PIK3CB, ITPKBMore
Bepotastinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Bepotastinehsa04144Endocytosis4.10E-023O75351, P62491, Q14161VPS4B, RAB11A, GIT2More
Bepotastinehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Bepotastinehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Bepotastinehsa04217Necroptosis2.34E-0513P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPIDMore
Bepotastinehsa04360Axon guidance1.71E-024P20827, O95631, P42338, P23528EFNA1, NTN1, PIK3CB, CFL1More
Bepotastinehsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Bepotastinehsa04530Tight junction3.60E-035P63261, P16989, P56750, Q92974, Q14247ACTG1, CSDA, CLDN17, ARHGEF2, CTTNMore
Bepotastinehsa04550Signaling pathways regulating pluripotency of stem cells2.16E-022P04628, P40189WNT1, IL6STMore
Bepotastinehsa04610Complement and coagulation cascades2.78E-031P0C0L4C4AMore
Bepotastinehsa04613Neutrophil extracellular trap formation2.15E-0511P11215, Q13547, P04908, Q93077, P58876, P62807, Q16778, O60814, P68431, O43315, Q16539ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Bepotastinehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Bepotastinehsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Bepotastinehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Bepotastinehsa04623Cytosolic DNA-sensing pathway2.63E-043P01568, Q13546, P25963IFNA21, RIPK1, NFKBIAMore
Bepotastinehsa04630JAK-STAT signaling pathway3.09E-033O75925, P40189, Q06124PIAS1, IL6ST, PTPN11More
Bepotastinehsa04657IL-17 signaling pathway4.55E-025O00463, Q16539, P49841, P09341, P14780TRAF5, MAPK14, GSK3B, CXCL1, MMP9More
Bepotastinehsa04659Th17 cell differentiation4.38E-024P42224, P14784, P40189, P08238STAT1, IL2RB, IL6ST, HSP90AB1More
Bepotastinehsa04662B cell receptor signaling pathway1.49E-035P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Bepotastinehsa04664Fc epsilon RI signaling pathway2.32E-023P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Bepotastinehsa04666Fc gamma R-mediated phagocytosis3.08E-023P42338, P23528, P14598PIK3CB, CFL1, NCF1More
Bepotastinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Bepotastinehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Bepotastinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Bepotastinehsa04724Glutamatergic synapse5.94E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Bepotastinehsa04725Cholinergic synapse4.10E-023P63218, P50151, P42338GNG5, GNG10, PIK3CBMore
Bepotastinehsa04727GABAergic synapse1.63E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Bepotastinehsa04914Progesterone-mediated oocyte maturation3.92E-023P42338, Q13370, P08238PIK3CB, PDE3B, HSP90AB1More
Bepotastinehsa04920Adipocytokine signaling pathway4.76E-032Q06124, Q9Y478PTPN11, PRKAB1More
Bepotastinehsa04924Renin secretion3.77E-022Q13370, P0DP23PDE3B, CALM1More
Bepotastinehsa04926Relaxin signaling pathway5.70E-035P42338, P63218, P50151, P49767, P49407PIK3CB, GNG5, GNG10, VEGFC, ARRB1More
Bepotastinehsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Bepotastinehsa04931Insulin resistance1.48E-022Q06124, Q9Y478PTPN11, PRKAB1More
Bepotastinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Bepotastinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Bepotastinehsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Bepotastinehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Bepotastinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Bepotastinehsa05016Huntington disease2.46E-053Q9GZM3, P52435, Q9NYC9POLR2J2, POLR2J, DNAH9More
Bepotastinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Bepotastinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Bepotastinehsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Bepotastinehsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Bepotastinehsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Bepotastinehsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Bepotastinehsa05133Pertussis4.94E-021P0C0L4C4AMore
Bepotastinehsa05140Leishmaniasis1.16E-0310O75015, P14598, P42224, P13765, O60603, P25963, P29350, P49006, Q16539, Q15080FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, PTPN6, MARCKSL1, MAPK14, NCF4More
Bepotastinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Bepotastinehsa05146Amoebiasis4.55E-025P09341, P14778, P27930, O60603, P05089CXCL1, IL1R1, IL1R2, TLR2, ARG1More
Bepotastinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Bepotastinehsa05163Human cytomegalovirus infection3.64E-027Q14643, P49841, P14778, P25025, Q16539, P04637, O00463ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Bepotastinehsa05168Herpes simplex virus 1 infection1.38E-0415P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, P42338, Q13398, Q9HCX3, Q03923, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PIK3CB, ZNF211, ZNF304, ZNF85, ZNF140, ZNF189, ZNF212More
Bepotastinehsa05169Epstein-Barr virus infection3.72E-026Q13547, P42338, P07948, Q13761, O75293, P07766HDAC1, PIK3CB, LYN, RUNX3, GADD45B, CD3EMore
Bepotastinehsa05200Pathways in cancer3.92E-029P42338, P08238, P42224, P43246, P14923, O75293, P0DP23, P14784, P40189PIK3CB, HSP90AB1, STAT1, MSH2, JUP, GADD45B, CALM1, IL2RB, IL6STMore
Bepotastinehsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Bepotastinehsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Bepotastinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Bepotastinehsa05212Pancreatic cancer1.72E-023P42338, P42224, O75293PIK3CB, STAT1, GADD45BMore
Bepotastinehsa05214Glioma1.72E-023P0DP23, P42338, O75293CALM1, PIK3CB, GADD45BMore
Bepotastinehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Bepotastinehsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Bepotastinehsa05226Gastric cancer2.94E-022P04628, P10826WNT1, RARBMore
Bepotastinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.55E-025O95267, P09693, O60603, Q16539, P01730RASGRP1, CD3G, TLR2, MAPK14, CD4More
Bepotastinehsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Bepotastinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Bepotastinehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Bepotastinehsa05415Diabetic cardiomyopathy4.54E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore
Bepotastinehsa05418Fluid shear stress and atherosclerosis2.84E-0310Q16539, P42338, P14598, P10599, P14780, P04637, P14778, P27930, P0DP23, P08238MAPK14, PIK3CB, NCF1, TXN, MMP9, TP53, IL1R1, IL1R2, CALM1, HSP90AB1More

Community members of Bepotastine (SDC: 6.32)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
Q9Y478PRKAB15'NoneAMPNoneactivated protein kinase subunit betaNone1Predicted10.14780.10880.55640.8479
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)