| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
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| Benzylpenicillin | hsa00030 | Pentose phosphate pathway | 8.97E-03 | 1 | P11413 | G6PD | More | | | Benzylpenicillin | hsa00053 | Ascorbate and aldarate metabolism | 4.93E-02 | 1 | P14550 | AKR1A1 | More | | | Benzylpenicillin | hsa00280 | Valine, leucine and isoleucine degradation | 3.41E-03 | 4 | P55809, Q9HCC0, Q02252, P11310 | OXCT1, MCCC2, ALDH6A1, ACADM | More | | | Benzylpenicillin | hsa00480 | Glutathione metabolism | 1.35E-02 | 1 | P11413 | G6PD | More | | | Benzylpenicillin | hsa00500 | Starch and sucrose metabolism | 2.67E-02 | 1 | P35573 | AGL | More | | | Benzylpenicillin | hsa00565 | Ether lipid metabolism | 4.93E-02 | 1 | Q8N661 | TMEM86B | More | | | Benzylpenicillin | hsa00670 | One carbon pool by folate | 1.32E-02 | 1 | P00374 | DHFR | More | | | Benzylpenicillin | hsa00750 | Vitamin B6 metabolism | 3.56E-02 | 1 | O00764 | PDXK | More | | | Benzylpenicillin | hsa00790 | Folate biosynthesis | 1.32E-02 | 1 | P00374 | DHFR | More | | | Benzylpenicillin | hsa00920 | Sulfur metabolism | 8.89E-03 | 1 | Q16762 | TST | More | | | Benzylpenicillin | hsa00970 | Aminoacyl-tRNA biosynthesis | 2.12E-02 | 1 | P14868 | DARS | More | | | Benzylpenicillin | hsa01200 | Carbon metabolism | 2.91E-02 | 1 | P11413 | G6PD | More | | | Benzylpenicillin | hsa01210 | 2-Oxocarboxylic acid metabolism | 3.56E-02 | 1 | P50213 | IDH3A | More | | | Benzylpenicillin | hsa01523 | Antifolate resistance | 1.98E-02 | 1 | P00374 | DHFR | More | | | Benzylpenicillin | hsa01524 | Platinum drug resistance | 4.57E-02 | 1 | P20585 | MSH3 | More | | | Benzylpenicillin | hsa02010 | ABC transporters | 4.93E-02 | 1 | Q8IZY2 | ABCA7 | More | | | Benzylpenicillin | hsa03008 | Ribosome biogenesis in eukaryotes | 2.99E-02 | 2 | P78345, Q9BVP2 | RPP38, GNL3 | More | | | Benzylpenicillin | hsa03013 | RNA transport | 5.29E-03 | 11 | P52298, Q09161, O14893, Q7Z3B4, P35658, P47813, Q14152, O75822, P78345, Q9Y6A5, P51114 | NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, RPP38, TACC3, FXR1 | More | | | Benzylpenicillin | hsa03060 | Protein export | 1.90E-02 | 2 | Q15070, O76094 | OXA1L, SRP72 | More | | | Benzylpenicillin | hsa03430 | Mismatch repair | 3.93E-02 | 1 | P20585 | MSH3 | More | | | Benzylpenicillin | hsa03450 | Non-homologous end-joining | 4.21E-02 | 1 | P13010 | XRCC5 | More | | | Benzylpenicillin | hsa04015 | Rap1 signaling pathway | 2.26E-02 | 3 | P25116, Q8TEU7, P08514 | F2R, RAPGEF6, ITGA2B | More | | | Benzylpenicillin | hsa04022 | cGMP-PKG signaling pathway | 1.05E-02 | 3 | P24844, Q8WYR1, Q15746 | MYL9, PIK3R5, MYLK | More | | | Benzylpenicillin | hsa04024 | cAMP signaling pathway | 1.40E-02 | 3 | P48058, P25116, P24844 | GRIA4, F2R, MYL9 | More | | | Benzylpenicillin | hsa04064 | NF-kappa B signaling pathway | 1.91E-04 | 12 | P10415, Q13489, P25963, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q13315, P24522 | BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, ATM, GADD45A | More | | | Benzylpenicillin | hsa04071 | Sphingolipid signaling pathway | 6.17E-04 | 8 | P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2 | PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2 | More | | | Benzylpenicillin | hsa04080 | Neuroactive ligand-receptor interaction | 1.18E-02 | 7 | P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730 | CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1 | More | | | Benzylpenicillin | hsa04115 | p53 signaling pathway | 3.57E-02 | 5 | P24522, Q13315, Q53FA7, O95067, P10415 | GADD45A, ATM, TP53I3, CCNB2, BCL2 | More | | | Benzylpenicillin | hsa04122 | Sulfur relay system | 8.89E-03 | 1 | Q16762 | TST | More | | | Benzylpenicillin | hsa04145 | Phagosome | 1.98E-02 | 8 | Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765 | NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOB | More | | | Benzylpenicillin | hsa04210 | Apoptosis | 1.52E-02 | 9 | Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643 | ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1 | More | | | Benzylpenicillin | hsa04213 | Longevity regulating pathway - multiple species | 2.85E-02 | 2 | Q9Y4H2, Q13547 | IRS2, HDAC1 | More | | | Benzylpenicillin | hsa04270 | Vascular smooth muscle contraction | 4.65E-02 | 2 | Q15746, P24844 | MYLK, MYL9 | More | | | Benzylpenicillin | hsa04340 | Hedgehog signaling pathway | 1.80E-02 | 4 | P49841, P22694, Q13635, P10415 | GSK3B, PRKACB, PTCH1, BCL2 | More | | | Benzylpenicillin | hsa04360 | Axon guidance | 1.66E-02 | 3 | P20827, P23528, Q06124 | EFNA1, CFL1, PTPN11 | More | | | Benzylpenicillin | hsa04390 | Hippo signaling pathway | 2.30E-02 | 3 | P63261, P04628, O43623 | ACTG1, WNT1, SNAI2 | More | | | Benzylpenicillin | hsa04510 | Focal adhesion | 3.36E-02 | 3 | P08514, Q15746, P24844 | ITGA2B, MYLK, MYL9 | More | | | Benzylpenicillin | hsa04512 | ECM-receptor interaction | 2.44E-02 | 2 | P07359, P08514 | GP1BA, ITGA2B | More | | | Benzylpenicillin | hsa04514 | Cell adhesion molecules | 4.65E-02 | 2 | P16109, O00501 | SELP, CLDN5 | More | | | Benzylpenicillin | hsa04530 | Tight junction | 7.42E-04 | 4 | Q8TEU7, O00501, Q14247, P24844 | RAPGEF6, CLDN5, CTTN, MYL9 | More | | | Benzylpenicillin | hsa04550 | Signaling pathways regulating pluripotency of stem cells | 1.96E-02 | 3 | P04628, P40189, P14653 | WNT1, IL6ST, HOXB1 | More | | | Benzylpenicillin | hsa04610 | Complement and coagulation cascades | 6.67E-04 | 3 | P25116, P0C0L4, P10909 | F2R, C4A, CLU | More | | | Benzylpenicillin | hsa04611 | Platelet activation | 1.59E-05 | 5 | P25116, P08514, Q15746, Q8WYR1, P07359 | F2R, ITGA2B, MYLK, PIK3R5, GP1BA | More | | | Benzylpenicillin | hsa04613 | Neutrophil extracellular trap formation | 4.55E-05 | 18 | P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, P58876, Q16778, O60814, P14598, Q15080, P20160, P08311, P49913, P21730, P21462 | PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, H2BC5, HIST2H2BE, H2BC12, NCF1, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1 | More | | | Benzylpenicillin | hsa04614 | Renin-angiotensin system | 3.52E-02 | 1 | P10619 | CTSA | More | | | Benzylpenicillin | hsa04621 | NOD-like receptor signaling pathway | 3.10E-03 | 11 | Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838 | ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4 | More | | | Benzylpenicillin | hsa04630 | JAK-STAT signaling pathway | 4.43E-02 | 3 | P48551, P40189, Q06124 | IFNAR2, IL6ST, PTPN11 | More | | | Benzylpenicillin | hsa04650 | Natural killer cell mediated cytotoxicity | 2.95E-02 | 7 | P06239, P20963, Q13241, P26718, O14931, P26717, P26715 | LCK, CD247, KLRD1, KLRK1, NCR3, KLRC2, KLRC1 | More | | | Benzylpenicillin | hsa04658 | Th1 and Th2 cell differentiation | 4.79E-03 | 7 | P07766, P20963, P09693, P06239, P23771, Q9UL17, Q13761 | CD3E, CD247, CD3G, LCK, GATA3, TBX21, RUNX3 | More | | | Benzylpenicillin | hsa04660 | T cell receptor signaling pathway | 1.37E-03 | 13 | P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P07766, P20963, P09693, P01732, Q13191, P06239 | TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD8A, CBLB, LCK | More | | | Benzylpenicillin | hsa04668 | TNF signaling pathway | 2.59E-02 | 7 | P01375, O00463, Q13489, P25963, P20749, Q13077, P14780 | TNF, TRAF5, BIRC3, NFKBIA, BCL3, TRAF1, MMP9 | More | | | Benzylpenicillin | hsa04670 | Leukocyte transendothelial migration | 4.20E-02 | 7 | P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681 | MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK | More | | | Benzylpenicillin | hsa04724 | Glutamatergic synapse | 2.94E-02 | 2 | P48058, Q9NSB8 | GRIA4, HOMER2 | More | | | Benzylpenicillin | hsa04810 | Regulation of actin cytoskeleton | 1.38E-03 | 4 | P24844, Q15746, P08514, P25116 | MYL9, MYLK, ITGA2B, F2R | More | | | Benzylpenicillin | hsa04920 | Adipocytokine signaling pathway | 4.49E-02 | 4 | P25963, P33121, Q04759, P01375 | NFKBIA, ACSL1, PRKCQ, TNF | More | | | Benzylpenicillin | hsa04921 | Oxytocin signaling pathway | 6.37E-03 | 3 | Q15746, P24844, Q8WYR1 | MYLK, MYL9, PIK3R5 | More | | | Benzylpenicillin | hsa04924 | Renin secretion | 8.24E-03 | 3 | P22694, P07550, Q14643 | PRKACB, ADRB2, ITPR1 | More | | | Benzylpenicillin | hsa04964 | Proximal tubule bicarbonate reclamation | 4.93E-02 | 1 | P00918 | CA2 | More | | | Benzylpenicillin | hsa04966 | Collecting duct acid secretion | 4.93E-02 | 1 | P00918 | CA2 | More | | | Benzylpenicillin | hsa04970 | Salivary secretion | 4.49E-02 | 4 | P22694, Q14643, P17252, P49913 | PRKACB, ITPR1, PRKCA, CAMP | More | | | Benzylpenicillin | hsa05034 | Alcoholism | 2.10E-03 | 4 | Q13547, P58876, Q16778, O60814 | HDAC1, H2BC5, HIST2H2BE, H2BC12 | More | | | Benzylpenicillin | hsa05130 | Pathogenic Escherichia coli infection | 2.51E-02 | 3 | Q14247, O00501, P25116 | CTTN, CLDN5, F2R | More | | | Benzylpenicillin | hsa05131 | Shigellosis | 3.34E-02 | 11 | P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32 | TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF | More | | | Benzylpenicillin | hsa05132 | Salmonella infection | 2.98E-02 | 11 | P51617, P25963, P01375, Q9UJU2, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509 | IRAK1, NFKBIA, TNF, LEF1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3 | More | | | Benzylpenicillin | hsa05133 | Pertussis | 4.20E-02 | 1 | P0C0L4 | C4A | More | | | Benzylpenicillin | hsa05140 | Leishmaniasis | 1.18E-02 | 7 | P14598, P13765, O60603, P25963, P01375, P51617, Q15080 | NCF1, HLA-DOB, TLR2, NFKBIA, TNF, IRAK1, NCF4 | More | | | Benzylpenicillin | hsa05143 | African trypanosomiasis | 1.31E-02 | 2 | P69905, P68871 | HBA2, HBB | More | | | Benzylpenicillin | hsa05144 | Malaria | 6.79E-03 | 6 | P69905, P68871, O60603, P01375, P35443, P26718 | HBA2, HBB, TLR2, TNF, THBS4, KLRK1 | More | | | Benzylpenicillin | hsa05145 | Toxoplasmosis | 3.07E-02 | 7 | P51617, P25963, P01375, P10415, Q13489, P13765, O60603 | IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2 | More | | | Benzylpenicillin | hsa05150 | Staphylococcus aureus infection | 2.44E-02 | 4 | P21462, Q14532, P59665, P59666 | FPR1, KRT32, DEFA1; DEFA1B, DEFA3 | More | | | Benzylpenicillin | hsa05152 | Tuberculosis | 2.07E-02 | 9 | Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617 | TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1 | More | | | Benzylpenicillin | hsa05161 | Hepatitis B | 2.33E-02 | 8 | P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765 | PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4 | More | | | Benzylpenicillin | hsa05170 | Human immunodeficiency virus 1 infection | 1.06E-03 | 13 | P01375, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5 | TNF, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2 | More | | | Benzylpenicillin | hsa05200 | Pathways in cancer | 3.23E-02 | 2 | P17301, P20585 | ITGA2, MSH3 | More | | | Benzylpenicillin | hsa05202 | Transcriptional misregulation in cancer | 2.72E-05 | 18 | Q12778, Q15532, Q13315, P14780, P27930, P14923, Q16548, P11215, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522 | FOXO1, SS18, ATM, MMP9, IL1R2, JUP, BCL2A1, ITGAM, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45A | More | | | Benzylpenicillin | hsa05203 | Viral carcinogenesis | 6.44E-03 | 4 | Q13547, P58876, Q16778, O60814 | HDAC1, H2BC5, HIST2H2BE, H2BC12 | More | | | Benzylpenicillin | hsa05222 | Small cell lung cancer | 2.79E-02 | 6 | Q13489, P10415, P25963, Q13077, O00463, P24522 | BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A | More | | | Benzylpenicillin | hsa05230 | Central carbon metabolism in cancer | 1.12E-02 | 1 | P11413 | G6PD | More | | | Benzylpenicillin | hsa05310 | Asthma | 3.88E-02 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | | Benzylpenicillin | hsa05321 | Inflammatory bowel disease | 1.70E-03 | 6 | O60603, P01375, P13765, Q14765, Q9UL17, P23771 | TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3 | More | | | Benzylpenicillin | hsa05322 | Systemic lupus erythematosus | 4.70E-03 | 10 | P08246, P08311, P01375, P10747, P13765, Q6FI13, P58876, Q16778, O60814, P05455 | ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, H2BC5, HIST2H2BE, H2BC12, SSB | More | | | Benzylpenicillin | hsa05332 | Graft-versus-host disease | 5.42E-04 | 5 | P13765, P10747, P01375, P26715, Q13241 | HLA-DOB, CD28, TNF, KLRC1, KLRD1 | More | | | Benzylpenicillin | hsa05410 | Hypertrophic cardiomyopathy | 2.63E-02 | 1 | P17301 | ITGA2 | More | | | Benzylpenicillin | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 3.44E-03 | 2 | P54284, P17301 | CACNB3, ITGA2 | More | | | Benzylpenicillin | hsa05415 | Diabetic cardiomyopathy | 3.59E-02 | 1 | P11413 | G6PD | More | | | Benzylpenicillin | hsa05416 | Viral myocarditis | 2.30E-02 | 2 | P10747, P63261 | CD28, ACTG1 | More | |
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