PharmaCoNets of Benzphetamine (SPCN: 80.22 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Benzphetaminehsa00030Pentose phosphate pathway1.08E-053P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Benzphetaminehsa00190Oxidative phosphorylation4.83E-063Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Benzphetaminehsa00230Purine metabolism1.81E-022P20839, Q02153IMPDH1, GUCY1B3More
Benzphetaminehsa00260Glycine, serine and threonine metabolism1.99E-021P22557ALAS2More
Benzphetaminehsa00565Ether lipid metabolism3.94E-021Q8N661TMEM86BMore
Benzphetaminehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Benzphetaminehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Benzphetaminehsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Benzphetaminehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Benzphetaminehsa00830Retinol metabolism3.15E-021P00325ADH1BMore
Benzphetaminehsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Benzphetaminehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Benzphetaminehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Benzphetaminehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Benzphetaminehsa01230Biosynthesis of amino acids2.22E-034P51854, P60891, Q99707, P37837TKTL1, PRPS1, MTR, TALDO1More
Benzphetaminehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Benzphetaminehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Benzphetaminehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Benzphetaminehsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Benzphetaminehsa03013RNA transport9.49E-0714O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, P23588, Q9Y6A5, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, EIF4B, TACC3, FXR1More
Benzphetaminehsa03020RNA polymerase1.31E-022P24928, P62487POLR2A, POLR2GMore
Benzphetaminehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Benzphetaminehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Benzphetaminehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Benzphetaminehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Benzphetaminehsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Benzphetaminehsa04071Sphingolipid signaling pathway2.55E-037P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Benzphetaminehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Benzphetaminehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Benzphetaminehsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Benzphetaminehsa04120Ubiquitin mediated proteolysis2.51E-036Q14145, Q13042, P62837, Q15751, O95071, P0CG47KEAP1, CDC16, UBE2D2, HERC1, UBR5, UBBMore
Benzphetaminehsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Benzphetaminehsa04137Mitophagy - animal9.52E-032Q07817, P0CG47BCL2L1, UBBMore
Benzphetaminehsa04145Phagosome1.62E-049Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Benzphetaminehsa04213Longevity regulating pathway - multiple species4.41E-034P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Benzphetaminehsa04217Necroptosis2.24E-0412P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPIDMore
Benzphetaminehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Benzphetaminehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Benzphetaminehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Benzphetaminehsa04610Complement and coagulation cascades2.78E-031P0C0L4C4AMore
Benzphetaminehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Benzphetaminehsa04613Neutrophil extracellular trap formation2.15E-0511P11215, Q13547, P04908, Q93077, P58876, P62807, Q16778, O60814, P68431, O43315, Q16539ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Benzphetaminehsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Benzphetaminehsa04640Hematopoietic cell lineage1.54E-039P21926, P14778, P27930, P11215, P25063, P07766, P01732, P01730, P09564CD9, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD4, CD7More
Benzphetaminehsa04650Natural killer cell mediated cytotoxicity5.49E-0612P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, Q14953, P26715PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KIR2DS5, KLRC1More
Benzphetaminehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Benzphetaminehsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Benzphetaminehsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Benzphetaminehsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Benzphetaminehsa04666Fc gamma R-mediated phagocytosis2.42E-025P23528, P06396, O14494, P14598, P17252CFL1, GSN, PLPP1, NCF1, PRKCAMore
Benzphetaminehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Benzphetaminehsa04672Intestinal immune network for IgA production1.62E-023P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Benzphetaminehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Benzphetaminehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Benzphetaminehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Benzphetaminehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Benzphetaminehsa04742Taste transduction1.01E-021P30939HTR1FMore
Benzphetaminehsa04744Phototransduction2.80E-022P62873, P0DP23GNB1, CALM1More
Benzphetaminehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Benzphetaminehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Benzphetaminehsa04916Melanogenesis4.80E-024P0DP23, Q9UJU2, P17252, P04628CALM1, LEF1, PRKCA, WNT1More
Benzphetaminehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Benzphetaminehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Benzphetaminehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Benzphetaminehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Benzphetaminehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Benzphetaminehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Benzphetaminehsa04966Collecting duct acid secretion1.68E-022P02730, P00918SLC4A1, CA2More
Benzphetaminehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Benzphetaminehsa04972Pancreatic secretion1.31E-022Q08828, P62491ADCY1, RAB11AMore
Benzphetaminehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Benzphetaminehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Benzphetaminehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Benzphetaminehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Benzphetaminehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Benzphetaminehsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Benzphetaminehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Benzphetaminehsa05132Salmonella infection2.93E-0210P51617, Q9UJU2, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371IRAK1, LEF1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Benzphetaminehsa05133Pertussis4.94E-021P0C0L4C4AMore
Benzphetaminehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Benzphetaminehsa05140Leishmaniasis5.18E-046P14598, P42224, O60603, P25963, P29350, Q15080NCF1, STAT1, TLR2, NFKBIA, PTPN6, NCF4More
Benzphetaminehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Benzphetaminehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Benzphetaminehsa05146Amoebiasis2.05E-0511P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, P22694, P12814CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1More
Benzphetaminehsa05152Tuberculosis5.68E-039Q13488, P0DP23, P48382, O60603, P10415, P13765, P01568, Q9UDY8, P51617TCIRG1, CALM1, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1More
Benzphetaminehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Benzphetaminehsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Benzphetaminehsa05170Human immunodeficiency virus 1 infection5.94E-0312P62873, P0DP23, P17252, O00463, Q14643, P01568, P51617, O60603, P23528, P10415, Q93034, Q9Y6Q5GNB1, CALM1, PRKCA, TRAF5, ITPR1, IFNA21, IRAK1, TLR2, CFL1, BCL2, CUL5, AP1M2More
Benzphetaminehsa05202Transcriptional misregulation in cancer4.29E-0315Q12778, Q15532, P14780, P27930, P14923, Q16548, P11215, Q13489, Q13077, P35226, P05164, P08246, Q9C0K0, Q13547, P12980FOXO1, SS18, MMP9, IL1R2, JUP, BCL2A1, ITGAM, BIRC3, TRAF1, BMI1, MPO, ELA2, BCL11B, HDAC1, LYL1More
Benzphetaminehsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Benzphetaminehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Benzphetaminehsa05205Proteoglycans in cancer1.39E-0313Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P01375, P23588, P04628, Q13635, P22694, P08962TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, TNF, EIF4B, WNT1, PTCH1, PRKACB, CD63More
Benzphetaminehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Benzphetaminehsa05218Melanoma1.07E-023P09619, Q9GZP0, Q02750PDGFRB, PDGFD, MAP2K1More
Benzphetaminehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Benzphetaminehsa05231Choline metabolism in cancer9.39E-034Q02750, P09619, Q9GZP0, O15245MAP2K1, PDGFRB, PDGFD, SLC22A1More
Benzphetaminehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.99E-048P42338, P19174, P07766, P20963, P06239, Q04759, Q9HC35, P01730PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQ, EML4, CD4More
Benzphetaminehsa05320Autoimmune thyroid disease8.64E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Benzphetaminehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Benzphetaminehsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Benzphetaminehsa05323Rheumatoid arthritis2.00E-023Q13488, P10747, O60603TCIRG1, CD28, TLR2More
Benzphetaminehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Benzphetaminehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Benzphetaminehsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Benzphetaminehsa05412Arrhythmogenic right ventricular cardiomyopathy3.10E-023Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Benzphetaminehsa05414Dilated cardiomyopathy2.11E-024Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Benzphetaminehsa05415Diabetic cardiomyopathy4.54E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore

Community members of Benzphetamine (SDC: 5.87)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P12271RLBP1RetinaldehydeNonebinding protein 1Predicted00.0840.106200.2543
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
Q07817BCL2L1BclNone2Nonelike protein 1Predicted10.08720.434911.9134
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P16083NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]Predicted00.29580.313400.7747
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)