PharmaCoNets of Benzocaine (SPCN: 15.60 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Benzocainehsa00250Alanine, aspartate and glutamate metabolism4.51E-021P51649ALDH5A1More
Benzocainehsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Benzocainehsa00531Glycosaminoglycan degradation3.97E-052P15586, P34059GNS, GALNSMore
Benzocainehsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate2.92E-021Q9Y2C2USTMore
Benzocainehsa01524Platinum drug resistance2.55E-022P04637, P48023TP53, FASLGMore
Benzocainehsa03008Ribosome biogenesis in eukaryotes2.06E-022Q9NYH9, Q9BVP2UTP6, GNL3More
Benzocainehsa03040Spliceosome3.17E-026Q14562, O43143, Q07955, Q13243, P11142, O75643DHX8, DHX15, SFRS1, SFRS5, HSPA8, ASCC3L1More
Benzocainehsa03050Proteasome3.93E-021P62195PSMC5More
Benzocainehsa04012ErbB signaling pathway4.28E-023P16333, P19174, P01106NCK1, PLCG1, MYCMore
Benzocainehsa04064NF-kappa B signaling pathway2.63E-0311P10415, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q13315, P24522, P09341BCL2, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, ATM, GADD45A, CXCL1More
Benzocainehsa04068FoxO signaling pathway6.45E-032P48023, Q96BR1FASLG, SGK3More
Benzocainehsa04070Phosphatidylinositol signaling system2.56E-024P19174, P0DP23, P23743, P27987PLCG1, CALM1, DGKA, ITPKBMore
Benzocainehsa04140Autophagy - animal4.55E-025P22694, Q14643, P10415, Q9H1Y0, Q04759PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Benzocainehsa04141Protein processing in endoplasmic reticulum3.07E-025P30101, P60604, P11142, P08238, Q9UNL2PDIA3, UBE2G2, HSPA8, HSP90AB1, SSR3More
Benzocainehsa04142Lysosome1.14E-023P43234, P15586, P34059CTSO, GNS, GALNSMore
Benzocainehsa04145Phagosome3.69E-027O75015, Q15080, P05164, P78380, O60603, P35443, P13765FCGR3B, NCF4, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Benzocainehsa04151PI3K-Akt signaling pathway4.21E-033P48023, P04637, Q96BR1FASLG, TP53, SGK3More
Benzocainehsa04210Apoptosis9.18E-034P04637, P24522, P43234, P63261TP53, GADD45A, CTSO, ACTG1More
Benzocainehsa04371Apelin signaling pathway1.96E-025P62873, P63218, Q13370, Q14814, P0DP23GNB1, GNG5, PDE3B, MEF2D, CALM1More
Benzocainehsa04612Antigen processing and presentation3.69E-027P13765, P48382, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Benzocainehsa04613Neutrophil extracellular trap formation2.16E-027P19174, P11215, Q13547, Q93077, P62807, O60814, P60709PLCG1, ITGAM, HDAC1, HIST1H2AC, HIST1H2BC, H2BC12, ACTBMore
Benzocainehsa04640Hematopoietic cell lineage4.72E-028P13612, P27930, P15144, P25063, P09693, P01732, P13765, P01375ITGA4, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNFMore
Benzocainehsa04650Natural killer cell mediated cytotoxicity3.19E-0311P01375, P06239, O60880, P20963, P48023, Q13241, P26718, O75015, P26717, Q14953, P26715TNF, LCK, SH2D1A, CD247, FASLG, KLRD1, KLRK1, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Benzocainehsa04658Th1 and Th2 cell differentiation2.41E-0413Q04759, P07766, P20963, P09693, P19174, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Benzocainehsa04659Th17 cell differentiation2.42E-0313Q04759, P19174, P06239, P42224, P14784, P13765, Q9HBE5, Q9UL17, P23771, P08238, P07766, P09693, P20963PRKCQ, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL21R, TBX21, GATA3, HSP90AB1, CD3E, CD3G, CD247More
Benzocainehsa04660T cell receptor signaling pathway4.75E-0310P01375, Q9UDY8, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239TNF, MALT1, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCKMore
Benzocainehsa04722Neurotrophin signaling pathway2.27E-022P48023, P04637FASLG, TP53More
Benzocainehsa04744Phototransduction8.50E-032P62873, P0DP23GNB1, CALM1More
Benzocainehsa04919Thyroid hormone signaling pathway2.48E-025P19174, P42224, P60709, Q13547, P01106PLCG1, STAT1, ACTB, HDAC1, MYCMore
Benzocainehsa05010Alzheimer disease1.23E-022P17861, P62195XBP1, PSMC5More
Benzocainehsa05012Parkinson disease7.44E-032P17861, P62195XBP1, PSMC5More
Benzocainehsa05014Amyotrophic lateral sclerosis2.32E-043P17861, P62195, Q53GS7XBP1, PSMC5, GLE1More
Benzocainehsa05017Spinocerebellar ataxia1.95E-032P17861, P62195XBP1, PSMC5More
Benzocainehsa05022Pathways of neurodegeneration - multiple diseases1.63E-022P17861, P62195XBP1, PSMC5More
Benzocainehsa05032Morphine addiction1.90E-024P62873, P63218, Q13370, P43250GNB1, GNG5, PDE3B, GRK6More
Benzocainehsa05034Alcoholism1.49E-037Q13547, P0DP23, P62873, P63218, Q93077, P62807, O60814HDAC1, CALM1, GNB1, GNG5, HIST1H2AC, HIST1H2BC, H2BC12More
Benzocainehsa05134Legionellosis4.28E-023P11215, P11142, P19875ITGAM, HSPA8, CXCL2More
Benzocainehsa05140Leishmaniasis3.53E-026P13612, O75015, P13765, O60603, P01375, Q15080ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, NCF4More
Benzocainehsa05144Malaria1.14E-025P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Benzocainehsa05146Amoebiasis1.95E-027P09341, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Benzocainehsa05160Hepatitis C3.81E-022P04637, P48023TP53, FASLGMore
Benzocainehsa05164Influenza A3.48E-022Q9GZY0, P48023NXF2; NXF2B, FASLGMore
Benzocainehsa05167Kaposi sarcoma-associated herpesvirus infection8.64E-037P42224, P62873, P63218, P19875, P19174, P01106, P0DP23STAT1, GNB1, GNG5, CXCL2, PLCG1, MYC, CALM1More
Benzocainehsa05168Herpes simplex virus 1 infection4.54E-034P04637, Q9GZY0, P48023, P98182TP53, NXF2; NXF2B, FASLG, ZNF200More
Benzocainehsa05169Epstein-Barr virus infection3.56E-027P01106, Q13547, P30101, Q13761, O75293, P42224, P07766MYC, HDAC1, PDIA3, RUNX3, GADD45B, STAT1, CD3EMore
Benzocainehsa05200Pathways in cancer2.60E-0212P08238, P42224, P19174, P01106, P43246, P20585, Q13547, P62873, P63218, O75293, P0DP23, P14784HSP90AB1, STAT1, PLCG1, MYC, MSH2, MSH3, HDAC1, GNB1, GNG5, GADD45B, CALM1, IL2RBMore
Benzocainehsa05202Transcriptional misregulation in cancer2.35E-0212Q13315, P14780, P27930, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P24522ATM, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Benzocainehsa05203Viral carcinogenesis3.56E-026P06746, P29083, Q13547, P12814, P62807, O60814POLB, GTF2E1, HDAC1, ACTN1, HIST1H2BC, H2BC12More
Benzocainehsa05205Proteoglycans in cancer4.43E-023P63261, P04637, Q06124ACTG1, TP53, PTPN11More
Benzocainehsa05206MicroRNAs in cancer3.17E-026P30304, P09493, P01106, Q9Y4H2, Q13547, P19174CDC25A, TPM1, MYC, IRS2, HDAC1, PLCG1More
Benzocainehsa05211Renal cell carcinoma7.75E-032Q06124, Q99814PTPN11, EPAS1More
Benzocainehsa05212Pancreatic cancer2.60E-022P04637, P24522TP53, GADD45AMore
Benzocainehsa05213Endometrial cancer2.60E-022P04637, P24522TP53, GADD45AMore
Benzocainehsa05214Glioma3.45E-035P0DP23, P04637, P19174, P24522, O75293CALM1, TP53, PLCG1, GADD45A, GADD45BMore
Benzocainehsa05216Thyroid cancer1.14E-022P04637, P24522TP53, GADD45AMore
Benzocainehsa05217Basal cell carcinoma2.06E-022P04637, P24522TP53, GADD45AMore
Benzocainehsa05218Melanoma1.14E-022P04637, P24522TP53, GADD45AMore
Benzocainehsa05219Bladder cancer4.51E-021P04637TP53More
Benzocainehsa05220Chronic myeloid leukemia7.90E-033Q06124, P04637, P24522PTPN11, TP53, GADD45AMore
Benzocainehsa05223Non-small cell lung cancer3.19E-022P04637, P24522TP53, GADD45AMore
Benzocainehsa05224Breast cancer4.51E-022P04637, P24522TP53, GADD45AMore
Benzocainehsa05225Hepatocellular carcinoma3.30E-023P04637, P24522, P63261TP53, GADD45A, ACTG1More
Benzocainehsa05310Asthma1.92E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Benzocainehsa05321Inflammatory bowel disease1.30E-047O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Benzocainehsa05322Systemic lupus erythematosus4.50E-024Q93077, P62807, O60814, P12814HIST1H2AC, HIST1H2BC, H2BC12, ACTN1More
Benzocainehsa05332Graft-versus-host disease2.17E-024P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More

Community members of Benzocaine (SDC: 1.57)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P19174PLCG11Nonephosphatidylinositol 4,5Nonebisphosphate phosphodiesterase gammaNone1Predicted00.06960.039711.1142
Q9Y4K0LOXL2Lysyl oxidase homolog 2Predicted00.02690.119800.253
P17861XBP1XNoneboxNonebinding protein 1Predicted00.29140.06510.46080.7367
P51649ALDH5A1SuccinateNonesemialdehyde dehydrogenase, mitochondrialPredicted00.1730.07780.1520.394
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)