PharmaCoNets of Benzatropine (SPCN: 241.25 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Benzatropinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Benzatropinehsa00040Pentose and glucuronate interconversions4.00E-021P15121AKR1B1More
Benzatropinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Benzatropinehsa00072Synthesis and degradation of ketone bodies2.78E-021Q01581HMGCS1More
Benzatropinehsa00190Oxidative phosphorylation1.03E-053Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Benzatropinehsa00220Arginine biosynthesis1.97E-022P15104, P49448GLUL, GLUD2More
Benzatropinehsa00250Alanine, aspartate and glutamate metabolism1.97E-022P49448, P15104GLUD2, GLULMore
Benzatropinehsa00340Histidine metabolism4.52E-021O95954FTCDMore
Benzatropinehsa00500Starch and sucrose metabolism5.14E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Benzatropinehsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Benzatropinehsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Benzatropinehsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Benzatropinehsa00564Glycerophospholipid metabolism9.70E-032Q9Y259, P49619CHKB, DGKGMore
Benzatropinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Benzatropinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Benzatropinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Benzatropinehsa00600Sphingolipid metabolism4.23E-033Q9BX95, Q8TCT0, P15289SGPP1, CERK, ARSAMore
Benzatropinehsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Benzatropinehsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Benzatropinehsa00730Thiamine metabolism3.54E-053Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Benzatropinehsa00740Riboflavin metabolism4.03E-021P24666ACP1More
Benzatropinehsa00770Pantothenate and CoA biosynthesis2.26E-043O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Benzatropinehsa00790Folate biosynthesis2.02E-021P15121AKR1B1More
Benzatropinehsa00900Terpenoid backbone biosynthesis1.40E-021Q01581HMGCS1More
Benzatropinehsa00910Nitrogen metabolism1.97E-022P15104, P49448GLUL, GLUD2More
Benzatropinehsa00970Aminoacyl-tRNA biosynthesis2.02E-054O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Benzatropinehsa00980Metabolism of xenobiotics by cytochrome P4506.38E-043P78417, P09211, P11712GSTO1, GSTP1, CYP2C9More
Benzatropinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Benzatropinehsa00983Drug metabolism - other enzymes1.64E-023P04183, P32320, P05164TK1, CDA, MPOMore
Benzatropinehsa01040Biosynthesis of unsaturated fatty acids2.92E-022P22307, Q9H5J4SCP2, ELOVL6More
Benzatropinehsa01100Metabolic pathways6.99E-0330Q9NR34, Q9Y259, P05089, P32320, Q13956, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, P49619, O95954, Q9HCC0, P33121, Q02318, P57054, Q9UBX8, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P35573, P06737MAN1C1, CHKB, ARG1, CDA, PDE6H, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, DGKG, FTCD, MCCC2, ACSL1, CYP27A1, PIGP, B4GALT6, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, AGL, PYGLMore
Benzatropinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Benzatropinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Benzatropinehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Benzatropinehsa01521EGFR tyrosine kinase inhibitor resistance3.30E-033P49841, P08069, Q9NRA1GSK3B, IGF1R, PDGFCMore
Benzatropinehsa01522Endocrine resistance6.93E-0410P14780, P22694, Q02750, Q9UM47, P04637, P42773, P46527, P08069, P10415, Q13323MMP9, PRKACB, MAP2K1, NOTCH3, TP53, CDKN2C, CDKN1B, IGF1R, BCL2, BIKMore
Benzatropinehsa01523Antifolate resistance1.43E-032Q92820, P04818GGH, TYMSMore
Benzatropinehsa02010ABC transporters1.66E-043P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Benzatropinehsa03010Ribosome2.25E-045P40429, Q07020, P27635, P05386, P62249RPL13A, RPL18, RPL10, RPLP1, RPS16More
Benzatropinehsa03020RNA polymerase4.40E-022P24928, P62487POLR2A, POLR2GMore
Benzatropinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Benzatropinehsa03040Spliceosome1.28E-0513O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Benzatropinehsa03050Proteasome2.26E-022P55036, P28074PSMD4, PSMB5More
Benzatropinehsa03320PPAR signaling pathway1.62E-022Q13133, Q02318NR1H3, CYP27A1More
Benzatropinehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Benzatropinehsa03430Mismatch repair4.38E-021P20585MSH3More
Benzatropinehsa03450Non-homologous end-joining1.02E-032P78527, P13010PRKDC, XRCC5More
Benzatropinehsa04010MAPK signaling pathway1.23E-033P08069, Q9H2K8, Q12933IGF1R, TAOK3, TRAF2More
Benzatropinehsa04014Ras signaling pathway1.42E-0315Q02750, P42338, P20827, Q15389, P49767, P08069, Q13009, P17252, Q7LDG7, P21359, P62879, P63218, P50151, P19174, P22694MAP2K1, PIK3CB, EFNA1, ANGPT1, VEGFC, IGF1R, TIAM1, PRKCA, RASGRP2, NF1, GNB2, GNG5, GNG10, PLCG1, PRKACBMore
Benzatropinehsa04015Rap1 signaling pathway7.59E-0411P20827, P49767, P08069, P06213, Q96FS4, P11215, Q13009, O00522, Q7LDG7, P42338, P19174EFNA1, VEGFC, IGF1R, INSR, SIPA1, ITGAM, TIAM1, KRIT1, RASGRP2, PIK3CB, PLCG1More
Benzatropinehsa04022cGMP-PKG signaling pathway2.55E-024P18848, Q8WYR1, P05141, P0DP24ATF4, PIK3R5, SLC25A5, CALM2More
Benzatropinehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Benzatropinehsa04062Chemokine signaling pathway9.51E-0619P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P49841, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, GSK3B, PIK3R5More
Benzatropinehsa04064NF-kappa B signaling pathway9.94E-0921P10415, Q13489, P51617, O00463, Q13546, P14778, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643, Q9UNE0BCL2, BIRC3, IRAK1, TRAF5, RIPK1, IL1R1, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTB, EDARMore
Benzatropinehsa04066HIF-1 signaling pathway1.49E-025P08069, P17252, Q15389, Q02750, P46527IGF1R, PRKCA, ANGPT1, MAP2K1, CDKN1BMore
Benzatropinehsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Benzatropinehsa04070Phosphatidylinositol signaling system3.47E-024P0DP23, Q14643, P23743, P17252CALM1, ITPR1, DGKA, PRKCAMore
Benzatropinehsa04071Sphingolipid signaling pathway6.16E-0810P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q12933, Q02156PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, TRAF2, PRKCEMore
Benzatropinehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Benzatropinehsa04080Neuroactive ligand-receptor interaction3.62E-0512P08311, P28472, Q15722, P21453, Q9H228, O00398, Q01726, P41968, P21462, P21730, Q16581, P07550CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, MC1R, MC3R, FPR1, C5AR1, C3AR1, ADRB2More
Benzatropinehsa04110Cell cycle4.77E-0912Q9UBD5, P30260, P06493, O60566, P78527, O75293, P04637, P49918, P30304, P33981, P42773, P01106ORC3, CDC27, CDK1, BUB1B, PRKDC, GADD45B, TP53, CDKN1C, CDC25A, TTK, CDKN2C, MYCMore
Benzatropinehsa04114Oocyte meiosis2.99E-021P08069IGF1RMore
Benzatropinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Benzatropinehsa04140Autophagy - animal7.34E-036P08069, P22694, Q14643, P10415, Q9H1Y0, Q04759IGF1R, PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Benzatropinehsa04145Phagosome1.21E-0510O75015, Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Benzatropinehsa04150mTOR signaling pathway2.32E-021P08069IGF1RMore
Benzatropinehsa04151PI3K-Akt signaling pathway7.24E-0632P62753, P42338, P43657, P25116, O43521, P04637, P27348, P09603, P20827, P49767, Q9GZP0, Q13362, P08238, Q8WYR1, P62873, P63218, P50151, P13612, P16144, O15335, Q13751, O60603, P14784, P01568, P18848, P10415, P17252, Q96BR1, O00141, Q6ZUJ8, P30281, P56279RPS6, PIK3CB, P2RY5, F2R, BCL2L11, TP53, YWHAQ, CSF1, EFNA1, VEGFC, PDGFD, PPP2R5C, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGA4, ITGB4, CHAD, LAMB3, TLR2, IL2RB, IFNA21, ATF4, BCL2, PRKCA, SGK3, SGK, PIK3AP1, CCND3, TCL1AMore
Benzatropinehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Benzatropinehsa04210Apoptosis2.49E-0310Q13315, P10415, O76075, O75460, P24522, Q16548, O43521, P43234, P18848, Q14643ATM, BCL2, DFFB, ERN1, GADD45A, BCL2A1, BCL2L11, CTSO, ATF4, ITPR1More
Benzatropinehsa04211Longevity regulating pathway1.34E-034Q12778, P08069, Q9UEF7, Q96KQ7FOXO1, IGF1R, KL, EHMT2More
Benzatropinehsa04213Longevity regulating pathway - multiple species1.14E-035P42338, P08069, Q9Y4H2, P11142, Q13547PIK3CB, IGF1R, IRS2, HSPA8, HDAC1More
Benzatropinehsa04217Necroptosis2.05E-0819P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, P10415, Q9H444, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CHMP4B, CHMP2A, PPIDMore
Benzatropinehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Benzatropinehsa04261Adrenergic signaling in cardiomyocytes2.31E-038P09493, P07550, P22694, P18848, Q13362, P0DP23, P17252, P10415TPM1, ADRB2, PRKACB, ATF4, PPP2R5C, CALM1, PRKCA, BCL2More
Benzatropinehsa04340Hedgehog signaling pathway2.62E-034P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Benzatropinehsa04360Axon guidance4.04E-026P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Benzatropinehsa04371Apelin signaling pathway1.00E-027P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Benzatropinehsa04510Focal adhesion3.48E-021P08069IGF1RMore
Benzatropinehsa04512ECM-receptor interaction4.41E-023Q13751, P13612, O15335LAMB3, ITGA4, CHADMore
Benzatropinehsa04520Adherens junction8.29E-031P08069IGF1RMore
Benzatropinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Benzatropinehsa04540Gap junction8.27E-046P17252, P22694, Q13509, P68371, Q02750, Q14643PRKCA, PRKACB, TUBB3, TUBB2C, MAP2K1, ITPR1More
Benzatropinehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Benzatropinehsa04610Complement and coagulation cascades1.27E-102P00734, P0C0L4F2, C4AMore
Benzatropinehsa04612Antigen processing and presentation3.47E-059P13765, P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Benzatropinehsa04613Neutrophil extracellular trap formation1.43E-0825P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, P04908, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Benzatropinehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Benzatropinehsa04621NOD-like receptor signaling pathway6.46E-0314Q16539, Q14643, P01568, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q13546, Q05823, P01375, P09341, P12838MAPK14, ITPR1, IFNA21, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RIPK1, RNASEL, TNF, CXCL1, DEFA4More
Benzatropinehsa04622RIG-I-like receptor signaling pathway1.28E-033P01568, Q13546, Q12933IFNA21, RIPK1, TRAF2More
Benzatropinehsa04623Cytosolic DNA-sensing pathway2.63E-043P01568, Q13546, P25963IFNA21, RIPK1, NFKBIAMore
Benzatropinehsa04640Hematopoietic cell lineage2.46E-0410P21926, P14778, P27930, P11215, P25063, P07766, P01732, P01730, P06127, P09564CD9, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD4, CD5, CD7More
Benzatropinehsa04650Natural killer cell mediated cytotoxicity4.72E-0913P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Benzatropinehsa04657IL-17 signaling pathway4.97E-048O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNFMore
Benzatropinehsa04658Th1 and Th2 cell differentiation6.81E-0813Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Benzatropinehsa04659Th17 cell differentiation5.84E-0614Q04759, P19174, P06239, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963PRKCQ, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Benzatropinehsa04660T cell receptor signaling pathway2.09E-0716P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Benzatropinehsa04662B cell receptor signaling pathway1.74E-025P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Benzatropinehsa04664Fc epsilon RI signaling pathway2.47E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Benzatropinehsa04666Fc gamma R-mediated phagocytosis3.08E-025O75015, P06396, O14494, P14598, P17252FCGR3B, GSN, PLPP1, NCF1, PRKCAMore
Benzatropinehsa04668TNF signaling pathway2.67E-036P01375, P18848, P19875, P01584, P14780, P20333TNF, ATF4, CXCL2, IL1B, MMP9, TNFRSF1BMore
Benzatropinehsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Benzatropinehsa04713Circadian entrainment2.60E-024P0DP23, P17252, P62873, Q14643CALM1, PRKCA, GNB1, ITPR1More
Benzatropinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Benzatropinehsa04720Long-term potentiation1.23E-036P17252, P0DP23, P51812, P22694, Q02750, Q14643PRKCA, CALM1, RPS6KA3, PRKACB, MAP2K1, ITPR1More
Benzatropinehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Benzatropinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Benzatropinehsa04723Retrograde endocannabinoid signaling1.88E-024Q14643, P17252, P62873, Q16718ITPR1, PRKCA, GNB1, NDUFA5More
Benzatropinehsa04724Glutamatergic synapse9.51E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Benzatropinehsa04725Cholinergic synapse1.34E-037P22694, Q14643, P17252, P62873, P62879, P10415, Q02750PRKACB, ITPR1, PRKCA, GNB1, GNB2, BCL2, MAP2K1More
Benzatropinehsa04726Serotonergic synapse2.43E-024P22694, P17252, P62879, Q02750PRKACB, PRKCA, GNB2, MAP2K1More
Benzatropinehsa04727GABAergic synapse1.52E-037P62879, P63218, P50151, P15104, P22694, O60296, P17252GNB2, GNG5, GNG10, GLUL, PRKACB, TRAK2, PRKCAMore
Benzatropinehsa04728Dopaminergic synapse2.76E-0311Q14643, P17252, P14416, P62873, P63218, P50151, P49841, Q16539, P49407, Q13362, P0DP23ITPR1, PRKCA, DRD2, GNB1, GNG5, GNG10, GSK3B, MAPK14, ARRB1, PPP2R5C, CALM1More
Benzatropinehsa04730Long-term depression1.34E-023Q14344, P08069, P07948GNA13, IGF1R, LYNMore
Benzatropinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Benzatropinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Benzatropinehsa04744Phototransduction1.02E-022P62873, P0DP23GNB1, CALM1More
Benzatropinehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Benzatropinehsa04912GnRH signaling pathway3.89E-023P17252, Q14643, P0DP23PRKCA, ITPR1, CALM1More
Benzatropinehsa04913Ovarian steroidogenesis5.67E-044P42330, P22694, P06213, P08069AKR1C3, PRKACB, INSR, IGF1RMore
Benzatropinehsa04914Progesterone-mediated oocyte maturation2.16E-021P08069IGF1RMore
Benzatropinehsa04916Melanogenesis2.18E-022P49841, Q01726GSK3B, MC1RMore
Benzatropinehsa04919Thyroid hormone signaling pathway2.22E-025P17252, Q02750, P22694, Q12778, Q9UM47PRKCA, MAP2K1, PRKACB, FOXO1, NOTCH3More
Benzatropinehsa04922Glucagon signaling pathway3.68E-036P22694, P06737, Q12778, Q13370, P0DP23, Q14643PRKACB, PYGL, FOXO1, PDE3B, CALM1, ITPR1More
Benzatropinehsa04923Regulation of lipolysis in adipocytes4.24E-034P07550, P06213, P42338, Q9Y4H2ADRB2, INSR, PIK3CB, IRS2More
Benzatropinehsa04924Renin secretion1.76E-055P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Benzatropinehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Benzatropinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Benzatropinehsa04928Parathyroid hormone synthesis, secretion and action5.42E-037Q14643, P22694, P23771, Q02750, P17252, P10415, Q9Y5Q3ITPR1, PRKACB, GATA3, MAP2K1, PRKCA, BCL2, MAFBMore
Benzatropinehsa04930Type II diabetes mellitus1.28E-032P06213, Q02156INSR, PRKCEMore
Benzatropinehsa04932Non-alcoholic fatty liver disease1.52E-0510P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, Q16718, O14521TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, NDUFA5, SDHDMore
Benzatropinehsa04933AGE-RAGE signaling pathway in diabetic complications1.19E-039P84022, Q13485, P42224, P10415, P42338, Q12778, P49767, P17252, P19174SMAD3, SMAD4, STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1More
Benzatropinehsa04940Type I diabetes mellitus2.61E-034P10747, P48023, P13765, P01375CD28, FASLG, HLA-DOB, TNFMore
Benzatropinehsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Benzatropinehsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Benzatropinehsa04964Proximal tubule bicarbonate reclamation2.17E-031P00918CA2More
Benzatropinehsa04966Collecting duct acid secretion5.21E-064Q13488, P02730, P00918, Q9Y666TCIRG1, SLC4A1, CA2, SLC12A7More
Benzatropinehsa04970Salivary secretion2.07E-034P07550, P22694, P17252, P49913ADRB2, PRKACB, PRKCA, CAMPMore
Benzatropinehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Benzatropinehsa04974Protein digestion and absorption2.47E-021Q7Z2H8SLC36A1More
Benzatropinehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Benzatropinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Benzatropinehsa05010Alzheimer disease7.04E-0419Q16718, O14521, P13073, Q14643, O15399, Q9NZJ5, O75460, P0DP23, P0DP24, Q13564, P01584, P18848, Q71U36, Q13509, P68371, P09603, P05141, P21796, Q08752NDUFA5, SDHD, COX4I1, ITPR1, GRIN2D, EIF2AK3, ERN1, CALM1, CALM2, APPBP1, IL1B, ATF4, TUBA1A, TUBB3, TUBB2C, CSF1, SLC25A5, VDAC1, PPIDMore
Benzatropinehsa05012Parkinson disease4.51E-0311Q16718, O14521, P13073, P05141, O75460, P18848, Q14643, P0DP23, P0DP24, Q13509, P68371NDUFA5, SDHD, COX4I1, SLC25A5, ERN1, ATF4, ITPR1, CALM1, CALM2, TUBB3, TUBB2CMore
Benzatropinehsa05016Huntington disease4.87E-025P13073, P24928, P62487, P05141, O75460COX4I1, POLR2A, POLR2G, SLC25A5, ERN1More
Benzatropinehsa05017Spinocerebellar ataxia2.43E-021P28074PSMB5More
Benzatropinehsa05020Prion disease1.31E-039Q16718, O14521, Q14643, Q13509, P68371, P49841, P14598, Q15080, Q16539NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, GSK3B, NCF1, NCF4, MAPK14More
Benzatropinehsa05022Pathways of neurodegeneration - multiple diseases2.05E-0519Q14643, Q13509, P68371, P49841, P10415, Q16718, O14521, P13073, O75460, P18848, Q13561, P05141, P17252, P20333, Q16539, P01584, Q08752, P0DP23, P0DP24ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, COX4I1, ERN1, ATF4, DCTN2, SLC25A5, PRKCA, TNFRSF1B, MAPK14, IL1B, PPID, CALM1, CALM2More
Benzatropinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Benzatropinehsa05032Morphine addiction1.34E-024P63218, P50151, Q07343, P43250GNG5, GNG10, PDE4B, GRK6More
Benzatropinehsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Benzatropinehsa05120Epithelial cell signaling in Helicobacter pylori infection1.84E-057Q16539, P09341, P19875, P19174, P25024, P25025, P07948MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYNMore
Benzatropinehsa05131Shigellosis3.33E-0310Q12933, P68431, Q02156, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752TRAF2, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCE, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPIDMore
Benzatropinehsa05132Salmonella infection5.51E-0410Q9UJU2, Q13546, Q13489, P10415, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371LEF1, RIPK1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2CMore
Benzatropinehsa05133Pertussis3.26E-052P0DP23, P0C0L4CALM1, C4AMore
Benzatropinehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Benzatropinehsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Benzatropinehsa05140Leishmaniasis2.75E-0813P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4More
Benzatropinehsa05143African trypanosomiasis1.11E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Benzatropinehsa05144Malaria1.12E-046P60033, P69905, P68871, P01375, P35443, P26718CD81, HBA2, HBB, TNF, THBS4, KLRK1More
Benzatropinehsa05145Toxoplasmosis1.11E-026P10415, Q13489, P42224, P13765, O60603, P29965BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Benzatropinehsa05146Amoebiasis1.14E-0613P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Benzatropinehsa05150Staphylococcus aureus infection1.34E-0411P0C0L4, P21730, P21462, O75015, P13765, Q16581, P13646, Q14532, P59665, P59666, P49913C4A, C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, CAMPMore
Benzatropinehsa05152Tuberculosis3.37E-0513Q13488, P0DP23, O75015, P42224, P48382, O60603, P01375, P10415, P13765, P01568, P49913, Q9UDY8, P51617TCIRG1, CALM1, FCGR3B, STAT1, RFX5, TLR2, TNF, BCL2, HLA-DOB, IFNA21, CAMP, MALT1, IRAK1More
Benzatropinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Benzatropinehsa05163Human cytomegalovirus infection1.87E-0310P01375, P63218, P50151, Q14643, P49841, P14778, P25025, Q16539, P04637, O00463TNF, GNG5, GNG10, ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Benzatropinehsa05165Human papillomavirus infection5.80E-0414P46527, Q02750, P16144, P35443, Q92796, Q05086, Q9UM47, P01568, P42224, Q13488, P22694, Q13362, Q12778, Q13315CDKN1B, MAP2K1, ITGB4, THBS4, DLG3, UBE3A, NOTCH3, IFNA21, STAT1, TCIRG1, PRKACB, PPP2R5C, FOXO1, ATMMore
Benzatropinehsa05167Kaposi sarcoma-associated herpesvirus infection4.73E-026P01568, P42224, P62873, Q14643, P0DP23, Q9UJU2IFNA21, STAT1, GNB1, ITPR1, CALM1, LEF1More
Benzatropinehsa05168Herpes simplex virus 1 infection6.00E-0416P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, Q9Y2A4, Q13398, P51522, Q9HCX3, P17038, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, ZNF443, ZNF211, ZNF83, ZNF304, ZNF43, ZNF140, ZNF189, ZNF212More
Benzatropinehsa05170Human immunodeficiency virus 1 infection4.67E-039P62873, P0DP23, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5GNB1, CALM1, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2More
Benzatropinehsa05171Coronavirus disease - COVID-193.87E-045P62249, P40429, P27635, Q07020, P05386RPS16, RPL13A, RPL10, RPL18, RPLP1More
Benzatropinehsa05200Pathways in cancer1.55E-0328Q13751, P42338, P08238, P42224, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, Q13547, P14923, P30281, P10415, Q13489, P49767, Q12778, P43657, P25116, P62873, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P01568, P14784LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, BCL2, BIRC3, VEGFC, FOXO1, P2RY5, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IFNA21, IL2RBMore
Benzatropinehsa05202Transcriptional misregulation in cancer2.75E-0723Q12778, Q15532, Q13315, P14780, P27930, P14923, Q15744, Q16548, P11215, Q13489, Q13077, O15550, P08069, P46527, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522FOXO1, SS18, ATM, MMP9, IL1R2, JUP, CEBPE, BCL2A1, ITGAM, BIRC3, TRAF1, UTX, IGF1R, CDKN1B, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45AMore
Benzatropinehsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Benzatropinehsa05204Chemical carcinogenesis1.09E-033P09211, P78417, P11712GSTP1, GSTO1, CYP2C9More
Benzatropinehsa05205Proteoglycans in cancer1.09E-026P14780, P01375, P08069, P23588, Q13635, P22694MMP9, TNF, IGF1R, EIF4B, PTCH1, PRKACBMore
Benzatropinehsa05206MicroRNAs in cancer3.66E-026P46527, Q9UM47, P16070, Q13315, P17252, Q02750CDKN1B, NOTCH3, CD44, ATM, PRKCA, MAP2K1More
Benzatropinehsa05212Pancreatic cancer3.94E-024P42338, P84022, Q13485, O75293PIK3CB, SMAD3, SMAD4, GADD45BMore
Benzatropinehsa05214Glioma9.95E-031P08069IGF1RMore
Benzatropinehsa05215Prostate cancer1.33E-021P08069IGF1RMore
Benzatropinehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Benzatropinehsa05218Melanoma9.63E-044P08069, P09619, Q9GZP0, Q02750IGF1R, PDGFRB, PDGFD, MAP2K1More
Benzatropinehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Benzatropinehsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Benzatropinehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Benzatropinehsa05224Breast cancer1.24E-025P08069, P49841, Q92837, P04637, P24522IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Benzatropinehsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Benzatropinehsa05231Choline metabolism in cancer5.58E-046Q02750, P09619, Q9GZP0, O15245, Q9Y259, P49619MAP2K1, PDGFRB, PDGFD, SLC22A1, CHKB, DGKGMore
Benzatropinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.93E-0613P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, P10747, Q04759, Q16539, Q9HC35, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Benzatropinehsa05310Asthma9.08E-043P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Benzatropinehsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Benzatropinehsa05321Inflammatory bowel disease3.34E-086O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Benzatropinehsa05322Systemic lupus erythematosus1.44E-0716O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P05455FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSBMore
Benzatropinehsa05323Rheumatoid arthritis5.16E-045P13765, Q13488, P10747, P09341, O60603HLA-DOB, TCIRG1, CD28, CXCL1, TLR2More
Benzatropinehsa05330Allograft rejection1.04E-035P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Benzatropinehsa05332Graft-versus-host disease1.05E-076P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Benzatropinehsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Benzatropinehsa05412Arrhythmogenic right ventricular cardiomyopathy6.71E-043Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Benzatropinehsa05414Dilated cardiomyopathy2.58E-034Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Benzatropinehsa05415Diabetic cardiomyopathy5.60E-058P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore
Benzatropinehsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Benzatropinehsa05418Fluid shear stress and atherosclerosis2.64E-037Q16539, P10599, P14780, P01375, P04637, P14778, P27930MAPK14, TXN, MMP9, TNF, TP53, IL1R1, IL1R2More

Community members of Benzatropine (SDC: 9.78)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterReported00.047710.02032.0442
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
Q9UEE5STK17ASerine/threonineNoneprotein kinase 17APredicted00.35040.337600.8504
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P61088UBE2NUbiquitinNoneconjugating enzyme E2 NPredicted00.11020.38250.37361.1937
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P22894MMP8Neutrophil collagenasePredicted10.10610.35700.767
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P41968MC3RMelanocortin receptor 3Predicted10.22350.263700.6392
Q01726MC1RMelanocyteNonestimulating hormone receptorPredicted10.0470.23750.0110.5095
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P09211GSTP1Glutathione SNonetransferase PPredicted00.32040.35230.45661.3213
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q02156PRKCEProtein kinase C epsilon typePredicted00.11750.52870.53771.6539
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
Q13822ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Predicted00.1130.3050.00630.6729
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
P78527PRKDCDNANonedependent protein kinase catalytic subunitPredicted00.1780.19440.24960.7273
Q13315ATMSerineNoneprotein kinase ATMPredicted10.77470.20140.93911.7293
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
SLC6A4P31645IC5024100