PharmaCoNets of Benserazide (SPCN: 4.63 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Benserazidehsa00020Citrate cycle (TCA cycle)2.78E-022O75390, P40926CS, MDH2More
Benserazidehsa00500Starch and sucrose metabolism1.34E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Benserazidehsa00730Thiamine metabolism3.83E-022P05186, P24666ALPL, ACP1More
Benserazidehsa03013RNA transport2.53E-026P62826, Q15287, Q9UBU9, P63279, Q13310, P20042RAN, RNPS1, NXF1, UBE2I, PABPC4, EIF2S2More
Benserazidehsa03015mRNA surveillance pathway4.25E-024Q13310, Q13362, Q15287, Q9UBU9PABPC4, PPP2R5C, RNPS1, NXF1More
Benserazidehsa04020Calcium signaling pathway4.11E-036Q96DU7, Q08828, Q13557, P61073, P05141, P51828ITPKC, ADCY1, CAMK2D, CXCR4, SLC25A5, ADCY7More
Benserazidehsa04114Oocyte meiosis2.64E-025Q13557, Q08828, P51828, P27348, Q13362CAMK2D, ADCY1, ADCY7, YWHAQ, PPP2R5CMore
Benserazidehsa04261Adrenergic signaling in cardiomyocytes3.32E-025Q08828, P51828, P18848, Q13362, Q13557ADCY1, ADCY7, ATF4, PPP2R5C, CAMK2DMore
Benserazidehsa04650Natural killer cell mediated cytotoxicity4.40E-026P78314, P06239, O60880, P20963, P26718, O75015SH3BP2, LCK, SH2D1A, CD247, KLRK1, FCGR3BMore
Benserazidehsa04658Th1 and Th2 cell differentiation9.73E-036P20963, P09693, Q16539, P06239, Q9UL17, P13765CD247, CD3G, MAPK14, LCK, TBX21, HLA-DOBMore
Benserazidehsa04659Th17 cell differentiation7.42E-037Q16539, P06239, P13765, P14778, Q9UL17, P09693, P20963MAPK14, LCK, HLA-DOB, IL1R1, TBX21, CD3G, CD247More
Benserazidehsa04725Cholinergic synapse2.45E-024Q08828, P51828, P18848, Q13557ADCY1, ADCY7, ATF4, CAMK2DMore
Benserazidehsa04750Inflammatory mediator regulation of TRP channels1.77E-024P01584, Q08828, P51828, Q13557IL1B, ADCY1, ADCY7, CAMK2DMore
Benserazidehsa04911Insulin secretion4.73E-034Q08828, P51828, P18848, Q13557ADCY1, ADCY7, ATF4, CAMK2DMore
Benserazidehsa04912GnRH signaling pathway2.45E-024Q08828, P51828, P18848, Q13557ADCY1, ADCY7, ATF4, CAMK2DMore
Benserazidehsa04916Melanogenesis3.73E-023Q13557, Q08828, P51828CAMK2D, ADCY1, ADCY7More
Benserazidehsa04925Aldosterone synthesis and secretion1.77E-024P18848, Q08828, P51828, Q13557ATF4, ADCY1, ADCY7, CAMK2DMore
Benserazidehsa04927Cortisol synthesis and secretion2.51E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Benserazidehsa04932Non-alcoholic fatty liver disease2.07E-025P18848, O75460, P01584, P12074, O15239ATF4, ERN1, IL1B, COX6A1, NDUFA1More
Benserazidehsa04934Cushing syndrome1.22E-024P18848, Q08828, P51828, Q13557ATF4, ADCY1, ADCY7, CAMK2DMore
Benserazidehsa04971Gastric acid secretion4.73E-034Q08828, P51828, P15311, Q13557ADCY1, ADCY7, VIL2, CAMK2DMore
Benserazidehsa05010Alzheimer disease1.50E-029O15239, P05496, P12074, Q00535, O75460, P01584, P18848, P05141, P28070NDUFA1, ATP5G1, COX6A1, CDK5, ERN1, IL1B, ATF4, SLC25A5, PSMB4More
Benserazidehsa05012Parkinson disease1.20E-028O15239, P12074, P05496, P05141, O75460, P18848, P28070, Q13557NDUFA1, COX6A1, ATP5G1, SLC25A5, ERN1, ATF4, PSMB4, CAMK2DMore
Benserazidehsa05016Huntington disease1.72E-028O15239, P12074, P05496, P30876, P62487, P05141, O75460, P28070NDUFA1, COX6A1, ATP5G1, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4More
Benserazidehsa05020Prion disease3.72E-028P01584, P46531, O15239, P05496, P12074, P18848, P05141, P28070IL1B, NOTCH1, NDUFA1, ATP5G1, COX6A1, ATF4, SLC25A5, PSMB4More
Benserazidehsa05022Pathways of neurodegeneration - multiple diseases1.74E-0210O15239, P12074, P05496, O75460, P18848, P05141, Q00535, P01584, Q13557, P28070NDUFA1, COX6A1, ATP5G1, ERN1, ATF4, SLC25A5, CDK5, IL1B, CAMK2D, PSMB4More
Benserazidehsa05144Malaria1.44E-024P60033, O60603, P35443, P26718CD81, TLR2, THBS4, KLRK1More
Benserazidehsa05163Human cytomegalovirus infection2.74E-027Q08828, P51828, P23458, P01584, P61073, Q13651, P18848ADCY1, ADCY7, JAK1, IL1B, CXCR4, IL10RA, ATF4More
Benserazidehsa05169Epstein-Barr virus infection4.41E-028P13765, Q13547, O00463, Q16539, P24522, O60603, P09693, P20963HLA-DOB, HDAC1, TRAF5, MAPK14, GADD45A, TLR2, CD3G, CD247More
Benserazidehsa05203Viral carcinogenesis3.32E-025P18848, P23458, P27348, Q7KZF4, P61978ATF4, JAK1, YWHAQ, SND1, HNRPKMore
Benserazidehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.03E-025P20963, P09693, P06239, O60603, Q16539CD247, CD3G, LCK, TLR2, MAPK14More

Community members of Benserazide (SDC: 1.24)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P63279UBE2ISUMONoneconjugating enzyme UBC9Predicted00.23320.05120.49830.7173
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)