PharmaCoNets of Benazepril (SPCN: 70.89 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Benazeprilhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Benazeprilhsa00240Pyrimidine metabolism4.29E-022P21589, P04183NT5E, TK1More
Benazeprilhsa00310Lysine degradation2.86E-022Q96KQ7, Q02809EHMT2, PLOD1More
Benazeprilhsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Benazeprilhsa00513Various types of N-glycan biosynthesis4.96E-021Q9NR34MAN1C1More
Benazeprilhsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Benazeprilhsa00564Glycerophospholipid metabolism4.29E-022Q6P1A2, P23743MBOAT5, DGKAMore
Benazeprilhsa00670One carbon pool by folate1.32E-021P00374DHFRMore
Benazeprilhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Benazeprilhsa00785Lipoic acid metabolism4.57E-021Q9Y234LIPT1More
Benazeprilhsa00790Folate biosynthesis1.32E-021P00374DHFRMore
Benazeprilhsa00970Aminoacyl-tRNA biosynthesis3.78E-022O95363, Q15046FARS2, KARSMore
Benazeprilhsa01523Antifolate resistance1.98E-021P00374DHFRMore
Benazeprilhsa01524Platinum drug resistance4.57E-021P20585MSH3More
Benazeprilhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Benazeprilhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Benazeprilhsa03040Spliceosome4.16E-0615Q14562, O43143, O60508, P08579, P26368, P52298, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, NCBP2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Benazeprilhsa03060Protein export1.90E-022Q15070, O76094OXA1L, SRP72More
Benazeprilhsa03430Mismatch repair3.93E-021P20585MSH3More
Benazeprilhsa04014Ras signaling pathway2.36E-028P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Benazeprilhsa04015Rap1 signaling pathway1.98E-0412P20827, P49767, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P08514, P17252, P19174EFNA1, VEGFC, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, ITGA2B, PRKCA, PLCG1More
Benazeprilhsa04022cGMP-PKG signaling pathway1.05E-023P24844, Q8WYR1, Q15746MYL9, PIK3R5, MYLKMore
Benazeprilhsa04024cAMP signaling pathway1.40E-023P48058, P25116, P24844GRIA4, F2R, MYL9More
Benazeprilhsa04061Viral protein interaction with cytokine and cytokine receptor1.39E-039P32248, P09341, P19875, P25024, P02775, P25025, P47992, Q9UBD3, P14784CCR7, CXCL1, CXCL2, CXCR1, PPBP, CXCR2, XCL1, XCL2, IL2RBMore
Benazeprilhsa04062Chemokine signaling pathway5.65E-0414P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5More
Benazeprilhsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Benazeprilhsa04070Phosphatidylinositol signaling system3.47E-024P0DP23, Q14643, P23743, P17252CALM1, ITPR1, DGKA, PRKCAMore
Benazeprilhsa04071Sphingolipid signaling pathway4.49E-024P17252, P21453, Q9BX95, P10415PRKCA, S1PR1, SGPP1, BCL2More
Benazeprilhsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Benazeprilhsa04080Neuroactive ligand-receptor interaction2.50E-037P48058, Q15722, P21453, O00398, P25116, P21462, Q16581GRIA4, LTB4R, S1PR1, P2RY10, F2R, FPR1, C3AR1More
Benazeprilhsa04114Oocyte meiosis3.27E-023Q9UJX4, P30260, Q16539ANAPC5, CDC27, MAPK14More
Benazeprilhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Benazeprilhsa04145Phagosome8.42E-036Q15080, P14598, Q13509, P68371, Q13488, O60603NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2More
Benazeprilhsa04151PI3K-Akt signaling pathway3.70E-0212P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3More
Benazeprilhsa04210Apoptosis7.52E-048P04637, Q13489, O76075, P24522, P43234, Q14643, P42575, P63261TP53, BIRC3, DFFB, GADD45A, CTSO, ITPR1, CASP2, ACTG1More
Benazeprilhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Benazeprilhsa04217Necroptosis2.64E-0310P01375, P01568, P48023, Q13489, Q13546, Q14765, Q6FI13, Q99878, P10415, O43633TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT4, H2AC18; H2AC19, H2AC14, BCL2, CHMP2AMore
Benazeprilhsa04270Vascular smooth muscle contraction4.65E-022Q15746, P24844MYLK, MYL9More
Benazeprilhsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Benazeprilhsa04360Axon guidance4.04E-026P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Benazeprilhsa04371Apelin signaling pathway1.00E-027P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Benazeprilhsa04510Focal adhesion3.36E-023P08514, Q15746, P24844ITGA2B, MYLK, MYL9More
Benazeprilhsa04512ECM-receptor interaction2.44E-022P07359, P08514GP1BA, ITGA2BMore
Benazeprilhsa04514Cell adhesion molecules4.65E-022P16109, O00501SELP, CLDN5More
Benazeprilhsa04530Tight junction7.42E-044Q8TEU7, O00501, Q14247, P24844RAPGEF6, CLDN5, CTTN, MYL9More
Benazeprilhsa04540Gap junction1.29E-024P17252, Q13509, P68371, Q14643PRKCA, TUBB3, TUBB2C, ITPR1More
Benazeprilhsa04610Complement and coagulation cascades9.44E-044P25116, P00734, P0C0L4, P10909F2R, F2, C4A, CLUMore
Benazeprilhsa04611Platelet activation1.19E-067Q14643, P25116, P08514, Q15746, Q8WYR1, P63261, P07359ITPR1, F2R, ITGA2B, MYLK, PIK3R5, ACTG1, GP1BAMore
Benazeprilhsa04613Neutrophil extracellular trap formation4.72E-0312P17252, O60603, P08246, P04908, Q6FI13, Q93077, P68431, P14598, Q15080, P21462, O43315, Q16539PRKCA, TLR2, ELA2, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1, AQP9, MAPK14More
Benazeprilhsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Benazeprilhsa04623Cytosolic DNA-sensing pathway2.86E-022P01568, Q13546IFNA21, RIPK1More
Benazeprilhsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Benazeprilhsa04650Natural killer cell mediated cytotoxicity2.83E-0410P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, P26715PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KLRC1More
Benazeprilhsa04658Th1 and Th2 cell differentiation4.19E-0610Q04759, P07766, P20963, P09693, P19174, P06239, P23771, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, LCK, GATA3, TBX21, IL2RB, RUNX3More
Benazeprilhsa04659Th17 cell differentiation9.05E-0511Q04759, P19174, P06239, P14784, P14778, Q9UL17, P84022, Q13485, P08238, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, SMAD3, SMAD4, HSP90AB1, CD3E, CD247More
Benazeprilhsa04660T cell receptor signaling pathway1.31E-0411Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCKMore
Benazeprilhsa04662B cell receptor signaling pathway1.74E-025P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Benazeprilhsa04664Fc epsilon RI signaling pathway2.47E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Benazeprilhsa04666Fc gamma R-mediated phagocytosis1.88E-024P23528, O14494, P14598, P17252CFL1, PLPP1, NCF1, PRKCAMore
Benazeprilhsa04672Intestinal immune network for IgA production1.35E-022P29965, P13765CD40LG, HLA-DOBMore
Benazeprilhsa04713Circadian entrainment2.60E-024P0DP23, P17252, P62873, Q14643CALM1, PRKCA, GNB1, ITPR1More
Benazeprilhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Benazeprilhsa04720Long-term potentiation5.06E-034P17252, Q16566, P0DP23, Q14643PRKCA, CAMK4, CALM1, ITPR1More
Benazeprilhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Benazeprilhsa04724Glutamatergic synapse2.94E-022P48058, Q9NSB8GRIA4, HOMER2More
Benazeprilhsa04725Cholinergic synapse2.72E-035Q14643, P17252, P62873, Q16566, P10415ITPR1, PRKCA, GNB1, CAMK4, BCL2More
Benazeprilhsa04726Serotonergic synapse4.49E-024Q14643, P17252, P62873, P33260ITPR1, PRKCA, GNB1, CYP2C18More
Benazeprilhsa04744Phototransduction1.02E-022P62873, P0DP23GNB1, CALM1More
Benazeprilhsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Benazeprilhsa04810Regulation of actin cytoskeleton1.38E-034P24844, Q15746, P08514, P25116MYL9, MYLK, ITGA2B, F2RMore
Benazeprilhsa04912GnRH signaling pathway3.89E-023P17252, Q14643, P0DP23PRKCA, ITPR1, CALM1More
Benazeprilhsa04914Progesterone-mediated oocyte maturation1.46E-023Q9UJX4, P30260, Q16539ANAPC5, CDC27, MAPK14More
Benazeprilhsa04918Thyroid hormone synthesis3.16E-022P17252, P27824PRKCA, CANXMore
Benazeprilhsa04921Oxytocin signaling pathway6.37E-033Q15746, P24844, Q8WYR1MYLK, MYL9, PIK3R5More
Benazeprilhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Benazeprilhsa04925Aldosterone synthesis and secretion1.14E-035Q14643, P15336, P0DP23, P17252, Q16566ITPR1, ATF2, CALM1, PRKCA, CAMK4More
Benazeprilhsa04927Cortisol synthesis and secretion3.20E-022Q14643, P15336ITPR1, ATF2More
Benazeprilhsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Benazeprilhsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Benazeprilhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Benazeprilhsa04966Collecting duct acid secretion2.86E-022Q13488, Q9Y666TCIRG1, SLC12A7More
Benazeprilhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Benazeprilhsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Benazeprilhsa05020Prion disease4.60E-039Q16718, O14521, Q14643, Q13509, P68371, P49841, P14598, Q15080, Q16539NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, GSK3B, NCF1, NCF4, MAPK14More
Benazeprilhsa05022Pathways of neurodegeneration - multiple diseases2.09E-0312Q14643, Q13509, P68371, P49841, P10415, Q16718, O14521, Q13561, P17252, Q16539, Q08752, P0DP23ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, DCTN2, PRKCA, MAPK14, PPID, CALM1More
Benazeprilhsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Benazeprilhsa05130Pathogenic Escherichia coli infection2.51E-023Q14247, O00501, P25116CTTN, CLDN5, F2RMore
Benazeprilhsa05132Salmonella infection1.11E-028Q9UJU2, Q13546, Q13489, P10415, O60603, Q13561, Q13509, P68371LEF1, RIPK1, BIRC3, BCL2, TLR2, DCTN2, TUBB3, TUBB2CMore
Benazeprilhsa05133Pertussis2.02E-034P0DP23, P23528, P09871, P0C0L4CALM1, CFL1, C1S, C4AMore
Benazeprilhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Benazeprilhsa05143African trypanosomiasis3.01E-034P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Benazeprilhsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Benazeprilhsa05152Tuberculosis4.18E-037Q13488, P0DP23, P48382, O60603, P10415, P01568, Q9UDY8TCIRG1, CALM1, RFX5, TLR2, BCL2, IFNA21, MALT1More
Benazeprilhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Benazeprilhsa05163Human cytomegalovirus infection4.73E-026P62873, Q14643, P0DP23, P17252, Q13546, P01568GNB1, ITPR1, CALM1, PRKCA, RIPK1, IFNA21More
Benazeprilhsa05170Human immunodeficiency virus 1 infection1.16E-0310P62873, P0DP23, P17252, Q13546, Q14643, P01568, O60603, P23528, P10415, Q9Y6Q5GNB1, CALM1, PRKCA, RIPK1, ITPR1, IFNA21, TLR2, CFL1, BCL2, AP1M2More
Benazeprilhsa05200Pathways in cancer2.03E-0319Q13751, P17301, P42338, P08238, P19174, P43246, P84022, Q13485, P20585, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784LAMB3, ITGA2, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, MSH3, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RBMore
Benazeprilhsa05205Proteoglycans in cancer4.46E-024Q12955, Q14247, P17252, P08962ANK3, CTTN, PRKCA, CD63More
Benazeprilhsa05212Pancreatic cancer9.39E-035P42338, P37173, P84022, Q13485, O75293PIK3CB, TGFBR2, SMAD3, SMAD4, GADD45BMore
Benazeprilhsa05214Glioma2.66E-023Q16566, P04637, P24522CAMK4, TP53, GADD45AMore
Benazeprilhsa05216Thyroid cancer2.72E-022P04637, P24522TP53, GADD45AMore
Benazeprilhsa05217Basal cell carcinoma4.79E-022P04637, P24522TP53, GADD45AMore
Benazeprilhsa05218Melanoma2.72E-022P04637, P24522TP53, GADD45AMore
Benazeprilhsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Benazeprilhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Benazeprilhsa05310Asthma1.35E-022P13765, P29965HLA-DOB, CD40LGMore
Benazeprilhsa05320Autoimmune thyroid disease3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Benazeprilhsa05330Allograft rejection1.76E-034P13765, P29965, P48023, P01375HLA-DOB, CD40LG, FASLG, TNFMore
Benazeprilhsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Benazeprilhsa05410Hypertrophic cardiomyopathy2.63E-021P17301ITGA2More
Benazeprilhsa05412Arrhythmogenic right ventricular cardiomyopathy8.47E-044P14923, P17301, P08514, Q9UJU2JUP, ITGA2, ITGA2B, LEF1More
Benazeprilhsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Benazeprilhsa05416Viral myocarditis4.29E-022P13765, P29965HLA-DOB, CD40LGMore

Community members of Benazepril (SDC: 4.77)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P08514ITGA2BIntegrin alphaNoneIIbPredicted10.07820.32480.7791.4677
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
O15550UTXLysineNonespecific demethylase 6APredicted00.0510.01110.3450.3927
P25116F2RProteinaseNoneactivated receptor 1Predicted10.20380.31960.51361.2547
P13612ITGA4Integrin alphaNone4Predicted00.11650.23860.68621.2217
Q13489BIRC3Baculoviral IAP repeatNonecontaining protein 3Predicted00.33620.04930.84721.114
P17301ITGA2Integrin alphaNone2Predicted00.52210.04470.68391.0343
P04637TP53Cellular tumor antigen p53Predicted10.10040.041711.1336
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)