PharmaCoNets of Bempedoic-acid (SPCN: 50.81 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Bempedoic-acidhsa00030Pentose phosphate pathway2.25E-033P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Bempedoic-acidhsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Bempedoic-acidhsa00190Oxidative phosphorylation8.71E-033Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Bempedoic-acidhsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Bempedoic-acidhsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Bempedoic-acidhsa00983Drug metabolism - other enzymes2.30E-033P04183, P32320, P05164TK1, CDA, MPOMore
Bempedoic-acidhsa01230Biosynthesis of amino acids3.21E-024P51854, P60891, P05089, P37837TKTL1, PRPS1, ARG1, TALDO1More
Bempedoic-acidhsa01523Antifolate resistance3.32E-023P41440, Q92820, P01375SLC19A1, GGH, TNFMore
Bempedoic-acidhsa03013RNA transport8.19E-047Q15287, Q9UBU9, P35658, P63279, P55884, O15371, P20042RNPS1, NXF1, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2More
Bempedoic-acidhsa03040Spliceosome3.98E-024Q15427, P38159, P61978, P11142SF3B4, RBMX, HNRPK, HSPA8More
Bempedoic-acidhsa03060Protein export1.43E-022P37108, Q15005SRP14, SPCS2More
Bempedoic-acidhsa04010MAPK signaling pathway1.53E-022Q9H2K8, Q12933TAOK3, TRAF2More
Bempedoic-acidhsa04012ErbB signaling pathway3.74E-023P21860, Q13557, O14944ERBB3, CAMK2D, EREGMore
Bempedoic-acidhsa04020Calcium signaling pathway6.50E-046Q96DU7, P45880, Q13557, P21860, P51828, P23634ITPKC, VDAC2, CAMK2D, ERBB3, ADCY7, ATP2B4More
Bempedoic-acidhsa04022cGMP-PKG signaling pathway4.72E-024Q99941, P23634, P51828, P45880CREBL1, ATP2B4, ADCY7, VDAC2More
Bempedoic-acidhsa04064NF-kappa B signaling pathway5.07E-0313P10415, Q13489, O00463, P01375, P29965, Q04759, Q9UDY8, Q16548, P06239, Q8WV28, Q13315, P24522, P09341BCL2, BIRC3, TRAF5, TNF, CD40LG, PRKCQ, MALT1, BCL2A1, LCK, BLNK, ATM, GADD45A, CXCL1More
Bempedoic-acidhsa04070Phosphatidylinositol signaling system3.47E-024P0DP23, Q14643, P23743, P17252CALM1, ITPR1, DGKA, PRKCAMore
Bempedoic-acidhsa04071Sphingolipid signaling pathway2.56E-049P17252, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2, Q12933, Q02156PRKCA, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2, TRAF2, PRKCEMore
Bempedoic-acidhsa04141Protein processing in endoplasmic reticulum3.64E-025Q99941, O75460, P11142, Q9H3Z4, P07900CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1More
Bempedoic-acidhsa04145Phagosome1.59E-037Q15080, P14598, Q13509, P68371, Q13488, O60603, P13765NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOBMore
Bempedoic-acidhsa04151PI3K-Akt signaling pathway4.50E-029P25116, P49767, Q13362, P62873, P16144, O60603, P01568, P10415, P17252F2R, VEGFC, PPP2R5C, GNB1, ITGB4, TLR2, IFNA21, BCL2, PRKCAMore
Bempedoic-acidhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Bempedoic-acidhsa04217Necroptosis9.14E-037P01568, Q13489, P42224, Q6FI13, P10415, O43633, Q08752IFNA21, BIRC3, STAT1, H2AC18; H2AC19, BCL2, CHMP2A, PPIDMore
Bempedoic-acidhsa04261Adrenergic signaling in cardiomyocytes3.49E-039P09493, P51828, Q99941, Q13362, P0DP23, Q13557, P17252, P10415, P23634TPM1, ADCY7, CREBL1, PPP2R5C, CALM1, CAMK2D, PRKCA, BCL2, ATP2B4More
Bempedoic-acidhsa04330Notch signaling pathway4.34E-022Q92542, P46531NCSTN, NOTCH1More
Bempedoic-acidhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Bempedoic-acidhsa04540Gap junction1.29E-024P17252, Q13509, P68371, Q14643PRKCA, TUBB3, TUBB2C, ITPR1More
Bempedoic-acidhsa04612Antigen processing and presentation2.94E-026P13765, P26715, P26717, Q13241, P01732, P01375HLA-DOB, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Bempedoic-acidhsa04613Neutrophil extracellular trap formation3.58E-028P17252, O60603, P08246, Q6FI13, P68431, P14598, Q15080, P21462PRKCA, TLR2, ELA2, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1More
Bempedoic-acidhsa04621NOD-like receptor signaling pathway3.40E-028Q14643, P10599, P43490, O00463, P29728, P01375, P09341, P12838ITPR1, TXN, PBEF1, TRAF5, OAS2, TNF, CXCL1, DEFA4More
Bempedoic-acidhsa04622RIG-I-like receptor signaling pathway2.47E-021Q12933TRAF2More
Bempedoic-acidhsa04640Hematopoietic cell lineage2.92E-027P27930, P25063, P07766, P09693, P01732, P13765, P01375IL1R2, CD24, CD3E, CD3G, CD8A, HLA-DOB, TNFMore
Bempedoic-acidhsa04650Natural killer cell mediated cytotoxicity6.34E-038P01375, P06239, O60880, P20963, Q13241, P26718, P26717, P26715TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, KLRC2, KLRC1More
Bempedoic-acidhsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Bempedoic-acidhsa04658Th1 and Th2 cell differentiation8.64E-059Q04759, P07766, P20963, P09693, P06239, Q14765, P23771, Q9UL17, P13765PRKCQ, CD3E, CD247, CD3G, LCK, STAT4, GATA3, TBX21, HLA-DOBMore
Bempedoic-acidhsa04659Th17 cell differentiation6.56E-049Q04759, P06239, P13765, Q9HBE5, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, LCK, HLA-DOB, IL21R, TBX21, GATA3, CD3E, CD3G, CD247More
Bempedoic-acidhsa04660T cell receptor signaling pathway4.22E-0410P01375, Q04759, O95267, Q08881, P07766, P20963, P09693, P01732, Q13191, P06239TNF, PRKCQ, RASGRP1, ITK, CD3E, CD247, CD3G, CD8A, CBLB, LCKMore
Bempedoic-acidhsa04668TNF signaling pathway4.74E-023Q99941, P01584, O95429CREBL1, IL1B, BAG4More
Bempedoic-acidhsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Bempedoic-acidhsa04713Circadian entrainment2.60E-024P0DP23, P17252, P62873, Q14643CALM1, PRKCA, GNB1, ITPR1More
Bempedoic-acidhsa04720Long-term potentiation3.89E-023P17252, P0DP23, Q14643PRKCA, CALM1, ITPR1More
Bempedoic-acidhsa04722Neurotrophin signaling pathway9.39E-032Q05655, P52566PRKCD, ARHGDIBMore
Bempedoic-acidhsa04723Retrograde endocannabinoid signaling1.88E-024Q14643, P17252, P62873, Q16718ITPR1, PRKCA, GNB1, NDUFA5More
Bempedoic-acidhsa04725Cholinergic synapse1.88E-024Q14643, P17252, P62873, P10415ITPR1, PRKCA, GNB1, BCL2More
Bempedoic-acidhsa04728Dopaminergic synapse3.55E-025Q14643, P17252, P62873, Q13362, P0DP23ITPR1, PRKCA, GNB1, PPP2R5C, CALM1More
Bempedoic-acidhsa04744Phototransduction1.02E-022P62873, P0DP23GNB1, CALM1More
Bempedoic-acidhsa04750Inflammatory mediator regulation of TRP channels3.74E-023P01584, P51828, Q13557IL1B, ADCY7, CAMK2DMore
Bempedoic-acidhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Bempedoic-acidhsa04911Insulin secretion1.48E-023P51828, Q99941, Q13557ADCY7, CREBL1, CAMK2DMore
Bempedoic-acidhsa04912GnRH signaling pathway3.89E-023P17252, Q14643, P0DP23PRKCA, ITPR1, CALM1More
Bempedoic-acidhsa04915Estrogen signaling pathway4.72E-024Q99941, P51828, P07900, P11142CREBL1, ADCY7, HSP90AA1, HSPA8More
Bempedoic-acidhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Bempedoic-acidhsa04922Glucagon signaling pathway3.47E-024Q12778, Q13370, P0DP23, Q14643FOXO1, PDE3B, CALM1, ITPR1More
Bempedoic-acidhsa04924Renin secretion8.71E-033Q14643, Q13370, P0DP23ITPR1, PDE3B, CALM1More
Bempedoic-acidhsa04925Aldosterone synthesis and secretion5.19E-034Q99941, P51828, Q13557, P23634CREBL1, ADCY7, CAMK2D, ATP2B4More
Bempedoic-acidhsa04930Type II diabetes mellitus9.83E-042Q05655, Q02156PRKCD, PRKCEMore
Bempedoic-acidhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Bempedoic-acidhsa04933AGE-RAGE signaling pathway in diabetic complications1.27E-025P42224, P10415, Q12778, P49767, P17252STAT1, BCL2, FOXO1, VEGFC, PRKCAMore
Bempedoic-acidhsa04934Cushing syndrome3.48E-034Q99941, P51828, O15169, Q13557CREBL1, ADCY7, AXIN1, CAMK2DMore
Bempedoic-acidhsa04966Collecting duct acid secretion2.86E-022Q13488, Q9Y666TCIRG1, SLC12A7More
Bempedoic-acidhsa04971Gastric acid secretion1.48E-023P51828, P15311, Q13557ADCY7, VIL2, CAMK2DMore
Bempedoic-acidhsa04974Protein digestion and absorption2.47E-021Q7Z2H8SLC36A1More
Bempedoic-acidhsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Bempedoic-acidhsa05010Alzheimer disease3.24E-0314Q92542, Q16718, O14521, P05496, P12074, Q14643, O75460, P0DP23, P01584, Q13509, P68371, O15169, P45880, Q08752NCSTN, NDUFA5, SDHD, ATP5G1, COX6A1, ITPR1, ERN1, CALM1, IL1B, TUBB3, TUBB2C, AXIN1, VDAC2, PPIDMore
Bempedoic-acidhsa05012Parkinson disease2.25E-026Q16718, O14521, Q14643, P0DP23, Q13509, P68371NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2CMore
Bempedoic-acidhsa05020Prion disease1.17E-0314P01584, P46531, P11142, Q16718, O14521, P05496, P12074, Q14643, P45880, Q13509, P68371, Q99941, P14598, Q15080IL1B, NOTCH1, HSPA8, NDUFA5, SDHD, ATP5G1, COX6A1, ITPR1, VDAC2, TUBB3, TUBB2C, CREBL1, NCF1, NCF4More
Bempedoic-acidhsa05022Pathways of neurodegeneration - multiple diseases4.48E-0310Q14643, Q13509, P68371, P10415, Q16718, O14521, Q13561, P17252, Q08752, P0DP23ITPR1, TUBB3, TUBB2C, BCL2, NDUFA5, SDHD, DCTN2, PRKCA, PPID, CALM1More
Bempedoic-acidhsa05131Shigellosis4.98E-0412Q12933, P68431, Q05655, Q02156, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752, P07737TRAF2, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCD, PRKCE, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID, PFN1More
Bempedoic-acidhsa05132Salmonella infection6.68E-0310Q9UJU2, P84095, Q13489, P10415, P07737, O60603, Q9BQS8, Q13561, Q13509, P68371LEF1, RHOG, BIRC3, BCL2, PFN1, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Bempedoic-acidhsa05140Leishmaniasis2.17E-036P14598, P42224, P13765, O60603, P29350, Q15080NCF1, STAT1, HLA-DOB, TLR2, PTPN6, NCF4More
Bempedoic-acidhsa05145Toxoplasmosis1.11E-026P10415, Q13489, P42224, P13765, O60603, P29965BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Bempedoic-acidhsa05146Amoebiasis3.63E-037P09341, P27930, P01375, P05089, P22694, P12814, P08311CXCL1, IL1R2, TNF, ARG1, PRKACB, ACTN1, CTSGMore
Bempedoic-acidhsa05152Tuberculosis7.93E-048Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1More
Bempedoic-acidhsa05165Human papillomavirus infection3.10E-028P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATMMore
Bempedoic-acidhsa05167Kaposi sarcoma-associated herpesvirus infection4.73E-026P01568, P42224, P62873, Q14643, P0DP23, Q9UJU2IFNA21, STAT1, GNB1, ITPR1, CALM1, LEF1More
Bempedoic-acidhsa05169Epstein-Barr virus infection3.13E-029P13765, Q13547, O00463, P24522, P01375, P29728, P07766, P09693, P20963HLA-DOB, HDAC1, TRAF5, GADD45A, TNF, OAS2, CD3E, CD3G, CD247More
Bempedoic-acidhsa05170Human immunodeficiency virus 1 infection4.67E-039P62873, P0DP23, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5GNB1, CALM1, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2More
Bempedoic-acidhsa05200Pathways in cancer4.99E-0212P42224, Q9UJU2, P17252, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, P0DP23, P01568STAT1, LEF1, PRKCA, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, CALM1, IFNA21More
Bempedoic-acidhsa05202Transcriptional misregulation in cancer3.92E-0210P14780, P27930, Q15744, Q16548, P05164, P12838, P08246, Q9C0K0, Q13547, P24522MMP9, IL1R2, CEBPE, BCL2A1, MPO, DEFA4, ELA2, BCL11B, HDAC1, GADD45AMore
Bempedoic-acidhsa05206MicroRNAs in cancer2.97E-036P15311, P21860, P61978, P46531, P63279, P22105VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXBMore
Bempedoic-acidhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.68E-026O95267, P07766, P20963, P09693, P06239, Q04759RASGRP1, CD3E, CD247, CD3G, LCK, PRKCQMore
Bempedoic-acidhsa05310Asthma8.13E-033P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Bempedoic-acidhsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Bempedoic-acidhsa05321Inflammatory bowel disease2.80E-046P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Bempedoic-acidhsa05322Systemic lupus erythematosus4.18E-037P08246, P09871, P10747, P13765, P29965, Q6FI13, P68431ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Bempedoic-acidhsa05323Rheumatoid arthritis1.29E-024P13765, Q13488, P10747, O60603HLA-DOB, TCIRG1, CD28, TLR2More
Bempedoic-acidhsa05330Allograft rejection1.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Bempedoic-acidhsa05332Graft-versus-host disease7.35E-034P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More
Bempedoic-acidhsa05415Diabetic cardiomyopathy3.55E-025P17252, P14598, Q15080, Q16718, O14521PRKCA, NCF1, NCF4, NDUFA5, SDHDMore
Bempedoic-acidhsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More

Community members of Bempedoic-acid (SDC: 3.85)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)