PharmaCoNets of Belinostat (SPCN: 67.21 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Belinostathsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Belinostathsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Belinostathsa00072Synthesis and degradation of ketone bodies2.78E-021Q01581HMGCS1More
Belinostathsa00190Oxidative phosphorylation1.00E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Belinostathsa00510N-Glycan biosynthesis1.00E-022O94777, Q9BVK2DPM2, ALG8More
Belinostathsa00561Glycerolipid metabolism3.09E-022P14550, Q86XP1AKR1A1, DGKHMore
Belinostathsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.47E-032O94777, Q14442DPM2, PIGHMore
Belinostathsa00565Ether lipid metabolism1.61E-042Q9Y6K0, Q8N661CEPT1, TMEM86BMore
Belinostathsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Belinostathsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Belinostathsa00600Sphingolipid metabolism4.47E-022Q96G23, Q86VZ5LASS2, SGMS1More
Belinostathsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Belinostathsa00900Terpenoid backbone biosynthesis1.40E-021Q01581HMGCS1More
Belinostathsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Belinostathsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Belinostathsa01100Metabolic pathways6.91E-0415Q9Y234, Q6ZQY3, P20839, O94777, Q9Y6K0, Q86XP1, P14550, Q9UHK6, Q86VZ5, Q96G23, Q9BVK2, Q14442, Q06055, Q99437, Q9NVH6LIPT1, GADL1, IMPDH1, DPM2, CEPT1, DGKH, AKR1A1, AMACR, SGMS1, LASS2, ALG8, PIGH, ATP5G2, ATP6V0B, TMLHEMore
Belinostathsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Belinostathsa01521EGFR tyrosine kinase inhibitor resistance2.18E-022P49841, Q9NRA1GSK3B, PDGFCMore
Belinostathsa01522Endocrine resistance4.55E-025P14780, P22694, Q9UM47, P10415, Q13323MMP9, PRKACB, NOTCH3, BCL2, BIKMore
Belinostathsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Belinostathsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Belinostathsa03013RNA transport2.48E-0512O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, EIF4B, TACC3More
Belinostathsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Belinostathsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Belinostathsa04064NF-kappa B signaling pathway1.13E-0517P10415, Q13489, P51617, O00463, P14778, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q13315, P24522, P09341, P19875, Q06643BCL2, BIRC3, IRAK1, TRAF5, IL1R1, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, ATM, GADD45A, CXCL1, CXCL2, LTBMore
Belinostathsa04071Sphingolipid signaling pathway2.14E-068P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Belinostathsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Belinostathsa04080Neuroactive ligand-receptor interaction4.89E-0411P08311, Q15722, P21453, Q9H228, O00398, Q01726, P41968, P21462, P21730, Q16581, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, MC1R, MC3R, FPR1, C5AR1, C3AR1, ADRB2More
Belinostathsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Belinostathsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Belinostathsa04140Autophagy - animal3.94E-035P22694, Q14643, P10415, Q9H1Y0, Q04759PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Belinostathsa04145Phagosome1.45E-038O75015, Q15080, P14598, Q13509, P05164, O60603, P35443, P13765FCGR3B, NCF4, NCF1, TUBB3, MPO, TLR2, THBS4, HLA-DOBMore
Belinostathsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Belinostathsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Belinostathsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Belinostathsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Belinostathsa04217Necroptosis2.87E-038P01568, Q13489, P42224, P08238, Q6FI13, Q93077, O43633, Q08752IFNA21, BIRC3, STAT1, HSP90AB1, H2AC18; H2AC19, HIST1H2AC, CHMP2A, PPIDMore
Belinostathsa04330Notch signaling pathway3.09E-022P49768, P78504PSEN1, JAG1More
Belinostathsa04340Hedgehog signaling pathway2.62E-034P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Belinostathsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Belinostathsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Belinostathsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Belinostathsa04612Antigen processing and presentation3.22E-038P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Belinostathsa04613Neutrophil extracellular trap formation4.60E-0720P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Belinostathsa04621NOD-like receptor signaling pathway2.62E-0211Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4More
Belinostathsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Belinostathsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Belinostathsa04650Natural killer cell mediated cytotoxicity1.54E-0513P16298, P50591, P19174, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, P26717, P26715PPP3CB, TNFSF10, PLCG1, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, KLRC2, KLRC1More
Belinostathsa04657IL-17 signaling pathway5.21E-038O00463, Q16539, P49841, P09341, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, LCN2, TNFMore
Belinostathsa04658Th1 and Th2 cell differentiation6.81E-0813Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Belinostathsa04659Th17 cell differentiation8.48E-0511Q04759, P19174, P06239, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Belinostathsa04660T cell receptor signaling pathway1.93E-0616P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Belinostathsa04666Fc gamma R-mediated phagocytosis3.08E-025O75015, P06396, O14494, P14598, P17252FCGR3B, GSN, PLPP1, NCF1, PRKCAMore
Belinostathsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Belinostathsa04721Synaptic vesicle cycle2.82E-034Q13488, Q99437, P43005, P31645TCIRG1, ATP6V0B, SLC1A1, SLC6A4More
Belinostathsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Belinostathsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Belinostathsa04916Melanogenesis2.18E-022P49841, Q01726GSK3B, MC1RMore
Belinostathsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Belinostathsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Belinostathsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Belinostathsa04928Parathyroid hormone synthesis, secretion and action4.23E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Belinostathsa04940Type I diabetes mellitus4.18E-023P10747, P13765, P01375CD28, HLA-DOB, TNFMore
Belinostathsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Belinostathsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Belinostathsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Belinostathsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Belinostathsa05120Epithelial cell signaling in Helicobacter pylori infection2.44E-047Q99437, P09341, P19875, P10145, P19174, P25024, P25025ATP6V0B, CXCL1, CXCL2, IL8, PLCG1, CXCR1, CXCR2More
Belinostathsa05133Pertussis4.20E-021P0C0L4C4AMore
Belinostathsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Belinostathsa05140Leishmaniasis2.68E-0512P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MAPK14, IRAK1, NCF4More
Belinostathsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Belinostathsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Belinostathsa05146Amoebiasis7.41E-0512P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Belinostathsa05150Staphylococcus aureus infection1.65E-026P21730, P21462, O75015, P13765, Q16581, P49913C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, CAMPMore
Belinostathsa05152Tuberculosis8.54E-039O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Belinostathsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Belinostathsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Belinostathsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Belinostathsa05202Transcriptional misregulation in cancer1.51E-0520Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45AMore
Belinostathsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Belinostathsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Belinostathsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Belinostathsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Belinostathsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer6.79E-049P42338, P19174, P07766, P20963, P09693, P06239, O60603, P10747, Q04759PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQMore
Belinostathsa05310Asthma9.08E-043P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Belinostathsa05321Inflammatory bowel disease4.30E-076O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Belinostathsa05322Systemic lupus erythematosus1.24E-0413O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSBMore
Belinostathsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Belinostathsa05332Graft-versus-host disease2.17E-055P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Belinostathsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Belinostathsa05415Diabetic cardiomyopathy1.07E-026P17252, P14598, Q15080, Q16718, O14521, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDHMore

Community members of Belinostat (SDC: 5.96)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q13547HDAC1Histone deacetylase 1Reported00.044710.9863.0084
Q92769HDAC2Histone deacetylase 2Reported10.047310.9863.0097
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P22894MMP8Neutrophil collagenasePredicted10.10610.35700.767
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q01726MC1RMelanocyteNonestimulating hormone receptorPredicted10.0470.23750.0110.5095
P41968MC3RMelanocortin receptor 3Predicted10.22350.263700.6392
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P10145IL8InterleukinNone8Predicted10.19670.130411.3591
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
HDAC1Q13547IC5015
HDAC1Q13547IC5018
HDAC1Q13547IC5020
HDAC1Q13547Ki0.9
HDAC1Q13547Ki26
HDAC2Q92769IC5049
HDAC2Q92769IC5050
HDAC2Q92769Ki0.9
HDAC2Q92769Ki22