PharmaCoNets of Bedaquiline (SPCN: 34.95 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Bedaquilinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Bedaquilinehsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Bedaquilinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Bedaquilinehsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Bedaquilinehsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Bedaquilinehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Bedaquilinehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Bedaquilinehsa01522Endocrine resistance7.98E-034Q9UM47, P42773, P46527, P08069NOTCH3, CDKN2C, CDKN1B, IGF1RMore
Bedaquilinehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Bedaquilinehsa03013RNA transport8.19E-047Q15287, Q9UBU9, P35658, P63279, P55884, O15371, P20042RNPS1, NXF1, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2More
Bedaquilinehsa03040Spliceosome3.98E-024Q15427, P38159, P61978, P11142SF3B4, RBMX, HNRPK, HSPA8More
Bedaquilinehsa03060Protein export1.43E-022P37108, Q15005SRP14, SPCS2More
Bedaquilinehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Bedaquilinehsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Bedaquilinehsa04012ErbB signaling pathway3.74E-023P21860, Q13557, O14944ERBB3, CAMK2D, EREGMore
Bedaquilinehsa04014Ras signaling pathway3.65E-021P08069IGF1RMore
Bedaquilinehsa04015Rap1 signaling pathway2.99E-021P08069IGF1RMore
Bedaquilinehsa04020Calcium signaling pathway6.50E-046Q96DU7, P45880, Q13557, P21860, P51828, P23634ITPKC, VDAC2, CAMK2D, ERBB3, ADCY7, ATP2B4More
Bedaquilinehsa04022cGMP-PKG signaling pathway4.72E-024Q99941, P23634, P51828, P45880CREBL1, ATP2B4, ADCY7, VDAC2More
Bedaquilinehsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Bedaquilinehsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Bedaquilinehsa04114Oocyte meiosis2.99E-021P08069IGF1RMore
Bedaquilinehsa04140Autophagy - animal2.82E-021P08069IGF1RMore
Bedaquilinehsa04141Protein processing in endoplasmic reticulum3.64E-025Q99941, O75460, P11142, Q9H3Z4, P07900CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1More
Bedaquilinehsa04150mTOR signaling pathway2.32E-021P08069IGF1RMore
Bedaquilinehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Bedaquilinehsa04211Longevity regulating pathway2.16E-021P08069IGF1RMore
Bedaquilinehsa04213Longevity regulating pathway - multiple species1.66E-021P08069IGF1RMore
Bedaquilinehsa04261Adrenergic signaling in cardiomyocytes3.98E-024P51828, Q99941, Q13557, P23634ADCY7, CREBL1, CAMK2D, ATP2B4More
Bedaquilinehsa04330Notch signaling pathway4.34E-022Q92542, P46531NCSTN, NOTCH1More
Bedaquilinehsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Bedaquilinehsa04510Focal adhesion3.48E-021P08069IGF1RMore
Bedaquilinehsa04520Adherens junction8.29E-031P08069IGF1RMore
Bedaquilinehsa04530Tight junction4.35E-022P63261, Q92974ACTG1, ARHGEF2More
Bedaquilinehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Bedaquilinehsa04610Complement and coagulation cascades6.23E-061P0C0L4C4AMore
Bedaquilinehsa04612Antigen processing and presentation1.64E-028P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Bedaquilinehsa04613Neutrophil extracellular trap formation2.17E-0213O60603, P05164, P08246, Q9UM07, Q13547, Q92769, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Bedaquilinehsa04621NOD-like receptor signaling pathway2.37E-025P25963, Q14790, P49913, P59665, P59666NFKBIA, CASP8, CAMP, DEFA1; DEFA1B, DEFA3More
Bedaquilinehsa04625C-type lectin receptor signaling pathway4.80E-026Q9ULY5, P20749, Q14643, P01375, Q13191, Q16539CLEC4E, BCL3, ITPR1, TNF, CBLB, MAPK14More
Bedaquilinehsa04640Hematopoietic cell lineage2.52E-029P13612, P14778, P27930, P15144, P11836, P09693, P01732, P13765, P01375ITGA4, IL1R1, IL1R2, ANPEP, MS4A1, CD3G, CD8A, HLA-DOB, TNFMore
Bedaquilinehsa04650Natural killer cell mediated cytotoxicity1.88E-029P01375, P78314, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH3BP2, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Bedaquilinehsa04657IL-17 signaling pathway2.81E-027O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Bedaquilinehsa04658Th1 and Th2 cell differentiation7.47E-038Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOBMore
Bedaquilinehsa04659Th17 cell differentiation3.13E-028Q04759, Q16539, P13765, P14778, Q9UL17, P23771, P09693, P20963PRKCQ, MAPK14, HLA-DOB, IL1R1, TBX21, GATA3, CD3G, CD247More
Bedaquilinehsa04660T cell receptor signaling pathway8.00E-0310P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3BMore
Bedaquilinehsa04668TNF signaling pathway4.74E-023Q99941, P01584, O95429CREBL1, IL1B, BAG4More
Bedaquilinehsa04730Long-term depression1.16E-021P08069IGF1RMore
Bedaquilinehsa04750Inflammatory mediator regulation of TRP channels3.74E-023P01584, P51828, Q13557IL1B, ADCY7, CAMK2DMore
Bedaquilinehsa04911Insulin secretion1.48E-023P51828, Q99941, Q13557ADCY7, CREBL1, CAMK2DMore
Bedaquilinehsa04912GnRH signaling pathway4.72E-024Q16539, Q9Y6R4, Q14643, P22694MAPK14, MAP3K4, ITPR1, PRKACBMore
Bedaquilinehsa04913Ovarian steroidogenesis1.16E-021P08069IGF1RMore
Bedaquilinehsa04914Progesterone-mediated oocyte maturation2.16E-021P08069IGF1RMore
Bedaquilinehsa04915Estrogen signaling pathway4.72E-024Q99941, P51828, P07900, P11142CREBL1, ADCY7, HSP90AA1, HSPA8More
Bedaquilinehsa04920Adipocytokine signaling pathway4.72E-024P33121, Q04759, Q9Y4H2, P01375ACSL1, PRKCQ, IRS2, TNFMore
Bedaquilinehsa04925Aldosterone synthesis and secretion5.19E-034Q99941, P51828, Q13557, P23634CREBL1, ADCY7, CAMK2D, ATP2B4More
Bedaquilinehsa04934Cushing syndrome3.48E-034Q99941, P51828, O15169, Q13557CREBL1, ADCY7, AXIN1, CAMK2DMore
Bedaquilinehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Bedaquilinehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Bedaquilinehsa04971Gastric acid secretion1.48E-023P51828, P15311, Q13557ADCY7, VIL2, CAMK2DMore
Bedaquilinehsa05010Alzheimer disease2.07E-027Q92542, P05496, P12074, O75460, P01584, O15169, P45880NCSTN, ATP5G1, COX6A1, ERN1, IL1B, AXIN1, VDAC2More
Bedaquilinehsa05020Prion disease1.81E-027P01584, P46531, P11142, P05496, P12074, P45880, Q99941IL1B, NOTCH1, HSPA8, ATP5G1, COX6A1, VDAC2, CREBL1More
Bedaquilinehsa05133Pertussis4.24E-031P0C0L4C4AMore
Bedaquilinehsa05140Leishmaniasis1.31E-027P13612, O75015, P13765, O60603, P01375, Q16539, Q15080ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MAPK14, NCF4More
Bedaquilinehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Bedaquilinehsa05144Malaria2.19E-037P60033, P69905, P68871, O60603, P01375, P35443, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Bedaquilinehsa05146Amoebiasis7.47E-038P09341, P14778, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Bedaquilinehsa05150Staphylococcus aureus infection4.58E-034Q14532, P59665, P59666, P49913KRT32, DEFA1; DEFA1B, DEFA3, CAMPMore
Bedaquilinehsa05202Transcriptional misregulation in cancer1.53E-0522P01106, P41732, P14780, P27930, Q16548, Q13077, P08069, P46527, P35226, O60583, P05164, P59665, P59666, P12838, P08246, P42773, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522MYC, TSPAN7, MMP9, IL1R2, BCL2A1, TRAF1, IGF1R, CDKN1B, BMI1, CCNT2, MPO, DEFA1; DEFA1B, DEFA3, DEFA4, ELA2, CDKN2C, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Bedaquilinehsa05205Proteoglycans in cancer3.48E-021P08069IGF1RMore
Bedaquilinehsa05206MicroRNAs in cancer2.97E-036P15311, P21860, P61978, P46531, P63279, P22105VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXBMore
Bedaquilinehsa05214Glioma9.95E-031P08069IGF1RMore
Bedaquilinehsa05215Prostate cancer1.33E-021P08069IGF1RMore
Bedaquilinehsa05218Melanoma6.63E-031P08069IGF1RMore
Bedaquilinehsa05220Chronic myeloid leukemia4.90E-023P01106, P25963, P46527MYC, NFKBIA, CDKN1BMore
Bedaquilinehsa05224Breast cancer1.49E-021P08069IGF1RMore
Bedaquilinehsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Bedaquilinehsa05321Inflammatory bowel disease2.22E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Bedaquilinehsa05332Graft-versus-host disease2.76E-024P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More
Bedaquilinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Bedaquiline (SDC: 3.49)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P21730C5AR1C5a anaphylatoxin chemotactic receptor 1Predicted10.02580.21670.53960.986
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P53609PGGT1BGeranylgeranyl transferase typeNone1 subunit betaPredicted00.04990.02700.0789
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)