PharmaCoNets

PharmaCoNets of Bazedoxifene (S_PCN: 220.94 )

Bazedoxifene regulated-network (S_DN: 27.14)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Bazedoxifene

hsa00030

Pentose phosphate pathway

1.08E-05

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Bazedoxifene

hsa00052

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Bazedoxifene

hsa00130

Ubiquinone and other terpenoid-quinone biosynthesis

1.66E-02

Q9BQB6

VKORC1

Bazedoxifene

hsa00190

Oxidative phosphorylation

1.15E-06

P13073, Q16718, O15239, P12074, Q13488, P05496, O14521

COX4I1, NDUFA5, NDUFA1, COX6A1, TCIRG1, ATP5G1, SDHD

Bazedoxifene

hsa00220

Arginine biosynthesis

1.97E-02

P15104, P49448

GLUL, GLUD2

Bazedoxifene

hsa00230

Purine metabolism

1.81E-02

P20839, Q02153

IMPDH1, GUCY1B3

Bazedoxifene

hsa00250

Alanine, aspartate and glutamate metabolism

1.97E-02

P49448, P15104

GLUD2, GLUL

Bazedoxifene

hsa00260

Glycine, serine and threonine metabolism

1.99E-02

P22557

ALAS2

Bazedoxifene

hsa00280

Valine, leucine and isoleucine degradation

1.67E-02

P55809, Q9HCC0, Q02252, P11310

OXCT1, MCCC2, ALDH6A1, ACADM

Bazedoxifene

hsa00310

Lysine degradation

2.59E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Bazedoxifene

hsa00500

Starch and sucrose metabolism

1.67E-02

O43451, P06737

MGAM, PYGL

Bazedoxifene

hsa00512

Mucin type O-glycan biosynthesis

4.86E-02

O95395, Q9NY28

GCNT3, GALNT8

Bazedoxifene

hsa00520

Amino sugar and nucleotide sugar metabolism

2.24E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Bazedoxifene

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Bazedoxifene

hsa00561

Glycerolipid metabolism

2.21E-02

O14494, P06280, P23743

PLPP1, GLA, DGKA

Bazedoxifene

hsa00565

Ether lipid metabolism

3.94E-02

Q8N661

TMEM86B

Bazedoxifene

hsa00600

Sphingolipid metabolism

3.96E-02

Q9BX95, O14494, P06280

SGPP1, PLPP1, GLA

Bazedoxifene

hsa00630

Glyoxylate and dicarboxylate metabolism

9.62E-04

P40925, P40926, P15104

MDH1, MDH2, GLUL

Bazedoxifene

hsa00730

Thiamine metabolism

5.29E-03

P05186, P24666

ALPL, ACP1

Bazedoxifene

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Bazedoxifene

hsa00830

Retinol metabolism

4.40E-02

P00325

ADH1B

Bazedoxifene

hsa00860

Porphyrin and chlorophyll metabolism

1.69E-02

P36551, P30043

CPOX, BLVRB

Bazedoxifene

hsa00910

Nitrogen metabolism

1.97E-02

P15104, P49448

GLUL, GLUD2

Bazedoxifene

hsa00970

Aminoacyl-tRNA biosynthesis

2.12E-02

P14868

DARS

Bazedoxifene

hsa00983

Drug metabolism - other enzymes

8.82E-04

P20839, P32320, P05164, Q16772

IMPDH1, CDA, MPO, GSTA3

Bazedoxifene

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Bazedoxifene

hsa01210

2-Oxocarboxylic acid metabolism

3.43E-02

P50213

IDH3A

Bazedoxifene

hsa01230

Biosynthesis of amino acids

2.22E-03

P51854, P60891, Q99707, P37837

TKTL1, PRPS1, MTR, TALDO1

Bazedoxifene

hsa01240

Biosynthesis of cofactors

2.52E-02

Q9BQB6, P14550

VKORC1, AKR1A1

Bazedoxifene

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P08069

IGF1R

Bazedoxifene

hsa01522

Endocrine resistance

2.16E-02

P08069

IGF1R

Bazedoxifene

hsa01523

Antifolate resistance

1.43E-03

Q92820, P04818

GGH, TYMS

Bazedoxifene

hsa02010

ABC transporters

2.29E-02

P45844, P08183

ABCG1, ABCB1

Bazedoxifene

hsa03008

Ribosome biogenesis in eukaryotes

1.88E-02

O14980, O60832, Q9BVP2

XPO1, DKC1, GNL3

Bazedoxifene

hsa03010

Ribosome

1.95E-06

P62753, P39019, P42677, P62906, P62917, P46776, Q9H0U6, Q07020, P61513, Q02878, P63173, P27635, P05386, P62249, P23396

RPS6, RPS19, RPS27, RPL10A, RPL8, RPL27A, MRPL18, RPL18, RPL37A, RPL6, RPL38, RPL10, RPLP1, RPS16, RPS3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P62753	RPS6	40S ribosomal protein S6	0.721
P14625	HSP90B1	Endoplasmin	P62753	RPS6	40S ribosomal protein S6	0.738
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P39019	RPS19	40S ribosomal protein S19	0.7
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P39019	RPS19	40S ribosomal protein S19	0.733
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P42677	RPS27	40S ribosomal protein S27	0.738
P14625	HSP90B1	Endoplasmin	P62906	RPL10A	60S ribosomal protein L10a	0.718
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P62917	RPL8	60S ribosomal protein L8	0.763
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P62917	RPL8	60S ribosomal protein L8	0.814
P14625	HSP90B1	Endoplasmin	P46776	RPL27A	60S ribosomal protein L27a	0.741
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	Q9H0U6	MRPL18	39S ribosomal protein L18, mitochondrial	0.753
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	Q07020	RPL18	60S ribosomal protein L18	0.732
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	Q07020	RPL18	60S ribosomal protein L18	0.722
P14625	HSP90B1	Endoplasmin	Q07020	RPL18	60S ribosomal protein L18	0.724
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P61513	RPL37A	60S ribosomal protein L37a	0.787
P14625	HSP90B1	Endoplasmin	P61513	RPL37A	60S ribosomal protein L37a	0.8
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	Q02878	RPL6	60S ribosomal protein L6	0.753
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P63173	RPL38	60S ribosomal protein L38	0.742
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P27635	RPL10	60S ribosomal protein L10	0.708
P14625	HSP90B1	Endoplasmin	P27635	RPL10	60S ribosomal protein L10	0.715
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P05386	RPLP1	60S acidic ribosomal protein P1	0.777
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P05386	RPLP1	60S acidic ribosomal protein P1	0.781
P14625	HSP90B1	Endoplasmin	P62249	RPS16	40S ribosomal protein S16	0.77
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P23396	RPS3	40S ribosomal protein S3	0.777
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P23396	RPS3	40S ribosomal protein S3	0.701
P14625	HSP90B1	Endoplasmin	P23396	RPS3	40S ribosomal protein S3	0.8

Bazedoxifene

hsa03013

RNA transport

1.06E-07

P62826, O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q7Z3B4, P35658, P63279, Q14152, O75822, P78345, P20042, Q14240, P23588, Q9Y6A5, Q14232

RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, NUP54, NUP214, UBE2I, EIF3A, EIF3J, RPP38, EIF2S2, EIF4A2, EIF4B, TACC3, EIF2B1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15311	VIL2	Ezrin	P62826	RAN	GTP-binding nuclear protein Ran	0.77
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
P10415	BCL2	Apoptosis regulator Bcl-2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.888
P10415	BCL2	Apoptosis regulator Bcl-2	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.742
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
P10415	BCL2	Apoptosis regulator Bcl-2	O14893	GEMIN2	Gem-associated protein 2	0.853
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
P15311	VIL2	Ezrin	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.708
P15311	VIL2	Ezrin	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
P10415	BCL2	Apoptosis regulator Bcl-2	Q7Z3B4	NUP54	Nucleoporin p54	0.774
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
P10415	BCL2	Apoptosis regulator Bcl-2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.751
P15311	VIL2	Ezrin	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.848
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
P10415	BCL2	Apoptosis regulator Bcl-2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.734
P10415	BCL2	Apoptosis regulator Bcl-2	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.837
P10415	BCL2	Apoptosis regulator Bcl-2	P78345	RPP38	Ribonuclease P protein subunit p38	0.852
P15311	VIL2	Ezrin	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.741
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P10415	BCL2	Apoptosis regulator Bcl-2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.812
P15311	VIL2	Ezrin	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.73

Bazedoxifene

hsa03020

RNA polymerase

3.00E-02

P30876, P24928, P62487

POLR2B, POLR2A, POLR2G

Bazedoxifene

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Bazedoxifene

hsa03040

Spliceosome

4.48E-04

Q14562, O43143, O60508, P17844, P51991, P61978, Q07955, Q01130, Q13243, P11142

DHX8, DHX15, CDC40, DDX5, HNRPA3, HNRPK, SFRS1, SFRS2, SFRS5, HSPA8

Bazedoxifene

hsa03060

Protein export

4.42E-02

P37108, Q15005

SRP14, SPCS2

Bazedoxifene

hsa03410

Base excision repair

2.52E-02

P49005, P29372

POLD2, MPG

Bazedoxifene

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Bazedoxifene

hsa04010

MAPK signaling pathway

4.15E-02

P08069

IGF1R

Bazedoxifene

hsa04014

Ras signaling pathway

3.82E-03

Q9NRA1, P08069, Q13009, P0DP23, P62873, P63218, P50151, P19174

PDGFC, IGF1R, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1

Bazedoxifene

hsa04015

Rap1 signaling pathway

2.99E-02

P08069

IGF1R

Bazedoxifene

hsa04020

Calcium signaling pathway

1.60E-02

Q96DU7, Q08828, Q13557, P21860, P05141

ITPKC, ADCY1, CAMK2D, ERBB3, SLC25A5

Bazedoxifene

hsa04060

Cytokine-cytokine receptor interaction

4.62E-02

P01584, Q13651, P61073

IL1B, IL10RA, CXCR4

Bazedoxifene

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.48E-02

P09341, P19875, P25024, P25025, P14784

CXCL1, CXCL2, CXCR1, CXCR2, IL2RB

Bazedoxifene

hsa04062

Chemokine signaling pathway

1.17E-04

P25024, P25025, P09341, P19875, P07948, P42338, P19174, P62873, P63218, P50151, Q13009, P14598, P42224, P25963

CXCR1, CXCR2, CXCL1, CXCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, TIAM1, NCF1, STAT1, NFKBIA

Bazedoxifene

hsa04064

NF-kappa B signaling pathway

1.69E-03

P14778, P01584, P19174, Q04759, P06239, P63279, Q8NHW4, P09341, P19875, Q06643, Q9NQC7

IL1R1, IL1B, PLCG1, PRKCQ, LCK, UBE2I, CCL4L2, CXCL1, CXCL2, LTB, CYLD

Bazedoxifene

hsa04066

HIF-1 signaling pathway

2.16E-02

P08069

IGF1R

Bazedoxifene

hsa04068

FoxO signaling pathway

1.99E-02

P08069

IGF1R

Bazedoxifene

hsa04070

Phosphatidylinositol signaling system

2.93E-02

P19174, P0DP23, P23743, P27987

PLCG1, CALM1, DGKA, ITPKB

Bazedoxifene

hsa04071

Sphingolipid signaling pathway

6.08E-04

P21453, Q9H228, P01375, Q13362, Q9UQC2

S1PR1, EDG8, TNF, PPP2R5C, GAB2

Bazedoxifene

hsa04072

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Bazedoxifene

hsa04080

Neuroactive ligand-receptor interaction

1.97E-02

P28472, P21453, Q9H228, P21730, P07550

GABRB3, S1PR1, EDG8, C5AR1, ADRB2

Bazedoxifene

hsa04110

Cell cycle

1.97E-05

P06493, O60566, O75293, P30304, P33981, P42773, P01106

CDK1, BUB1B, GADD45B, CDC25A, TTK, CDKN2C, MYC

Bazedoxifene

hsa04114

Oocyte meiosis

2.99E-02

P08069

IGF1R

Bazedoxifene

hsa04120

Ubiquitin mediated proteolysis

2.51E-03

Q14145, Q13042, P62837, Q15751, O95071, P0CG47

KEAP1, CDC16, UBE2D2, HERC1, UBR5, UBB

Bazedoxifene

hsa04136

Autophagy - other

5.92E-03

O94817, Q9H1Y0

ATG12, ATG5

Bazedoxifene

hsa04137

Mitophagy - animal

9.52E-03

Q07817, P0CG47

BCL2L1, UBB

Bazedoxifene

hsa04140

Autophagy - animal

2.82E-02

P08069

IGF1R

Bazedoxifene

hsa04141

Protein processing in endoplasmic reticulum

1.93E-06

P18848, P30101, P07384, O95487, Q15437, Q15436, P60604, Q99941, P11142, P07900, P08238, Q9NR31, P14625, O95816, Q9H173, Q9UNL2

ATF4, PDIA3, CAPN1, SEC24B, SEC23B, SEC23A, UBE2G2, CREBL1, HSPA8, HSP90AA1, HSP90AB1, SAR1A, HSP90B1, BAG2, SIL1, SSR3

Bazedoxifene

hsa04142

Lysosome

1.46E-02

P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916

HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2

Bazedoxifene

hsa04144

Endocytosis

2.12E-03

P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, P01889, P10321, P49418, Q9UMY4

HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, HLA-B, HLA-C, AMPH, SNX12

Bazedoxifene

hsa04145

Phagosome

2.72E-06

P11215, P60709, Q15075, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765, P01889, P10321

ITGAM, ACTB, EEA1, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB, HLA-B, HLA-C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11215	ITGAM	Integrin alpha-M	-0.78
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P10415	BCL2	Apoptosis regulator Bcl-2	Q15080	NCF4	Neutrophil cytosol factor 4	-0.951
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P10415	BCL2	Apoptosis regulator Bcl-2	P14598	NCF1	Neutrophil cytosol factor 1	-0.844
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.866
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13509	TUBB3	Tubulin beta-3 chain	0.789
P10415	BCL2	Apoptosis regulator Bcl-2	Q13509	TUBB3	Tubulin beta-3 chain	-0.809
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P68371	TUBB2C	Tubulin beta-4B chain	0.741
P10415	BCL2	Apoptosis regulator Bcl-2	P68371	TUBB2C	Tubulin beta-4B chain	-0.766
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.759
P10415	BCL2	Apoptosis regulator Bcl-2	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.718
P10415	BCL2	Apoptosis regulator Bcl-2	P05164	MPO	Myeloperoxidase	-0.81
P10415	BCL2	Apoptosis regulator Bcl-2	O60603	TLR2	Toll-like receptor 2	-0.884
P10415	BCL2	Apoptosis regulator Bcl-2	P35443	THBS4	Thrombospondin-4	-0.765
P10415	BCL2	Apoptosis regulator Bcl-2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.754
Q9H4A3	WNK1	Serine/threonine-protein kinase WNK1	P01889	HLA-B	HLA class I histocompatibility antigen, B alpha chain	0.774
Q9H4A3	WNK1	Serine/threonine-protein kinase WNK1	P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	0.774

Bazedoxifene

hsa04150

mTOR signaling pathway

2.32E-02

P08069

IGF1R

Bazedoxifene

hsa04151

PI3K-Akt signaling pathway

1.04E-04

P62753, P43657, P27348, P09603, Q9GZP0, P07900, P14625, P63218, P50151, P13612, O15335, Q16363, Q13751, P22105, Q99941, P18848, O00141

RPS6, P2RY5, YWHAQ, CSF1, PDGFD, HSP90AA1, HSP90B1, GNG5, GNG10, ITGA4, CHAD, LAMA4, LAMB3, TNXB, CREBL1, ATF4, SGK

Bazedoxifene

hsa04152

AMPK signaling pathway

1.99E-02

P08069

IGF1R

Bazedoxifene

hsa04210

Apoptosis

3.58E-02

O76075, P01375, Q9NR28, Q16548

DFFB, TNF, DIABLO, BCL2A1

Bazedoxifene

hsa04211

Longevity regulating pathway

5.33E-03

P08069, P51828, Q99941, P18848

IGF1R, ADCY7, CREBL1, ATF4

Bazedoxifene

hsa04213

Longevity regulating pathway - multiple species

9.82E-04

P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547

PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1

Bazedoxifene

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Bazedoxifene

hsa04217

Necroptosis

2.24E-04

P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752

TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPID

Bazedoxifene

hsa04218

Cellular senescence

3.71E-03

P01106, O75293, P30304, P06493, P01889, P10321

MYC, GADD45B, CDC25A, CDK1, HLA-B, HLA-C

Bazedoxifene

hsa04260

Cardiac muscle contraction

4.02E-02

P09493, P14927

TPM1, UQCRB

Bazedoxifene

hsa04261

Adrenergic signaling in cardiomyocytes

1.33E-03

P07550, P51828, P22694, Q99941, P18848, Q13362, Q13557

ADRB2, ADCY7, PRKACB, CREBL1, ATF4, PPP2R5C, CAMK2D

Bazedoxifene

hsa04270

Vascular smooth muscle contraction

9.46E-04

P0DP23, Q08828, P51828, P35579, P35749, P35318

CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM

Bazedoxifene

hsa04340

Hedgehog signaling pathway

3.32E-02

P49841, P22694

GSK3B, PRKACB

Bazedoxifene

hsa04350

TGF-beta signaling pathway

4.88E-02

P37173

TGFBR2

Bazedoxifene

hsa04360

Axon guidance

1.50E-02

P20827, P23528, Q06124

EFNA1, CFL1, PTPN11

Bazedoxifene

hsa04371

Apelin signaling pathway

7.95E-04

P62873, P63218, P50151, Q13370, Q14344, P84022, P0DP23

GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD3, CALM1

Bazedoxifene

hsa04390

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Bazedoxifene

hsa04510

Focal adhesion

3.48E-02

P08069

IGF1R

Bazedoxifene

hsa04512

ECM-receptor interaction

4.41E-02

Q13751, P13612, O15335

LAMB3, ITGA4, CHAD

Bazedoxifene

hsa04514

Cell adhesion molecules

3.29E-02

P01889, P10321

HLA-B, HLA-C

Bazedoxifene

hsa04520

Adherens junction

8.29E-03

P08069

IGF1R

Bazedoxifene

hsa04530

Tight junction

2.08E-02

P63261, Q9Y478, Q92974

ACTG1, PRKAB1, ARHGEF2

Bazedoxifene

hsa04540

Gap junction

1.08E-02

Q13509, P68371, Q71U36, Q9NRA1

TUBB3, TUBB2C, TUBA1A, PDGFC

Bazedoxifene

hsa04550

Signaling pathways regulating pluripotency of stem cells

1.99E-02

P08069

IGF1R

Bazedoxifene

hsa04610

Complement and coagulation cascades

7.11E-07

P00734, P0C0L4

F2, C4A

Bazedoxifene

hsa04612

Antigen processing and presentation

2.38E-05

P13765, P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01889, P10321, P01375

HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, HLA-B, HLA-C, TNF

Bazedoxifene

hsa04613

Neutrophil extracellular trap formation

3.82E-03

O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, Q93077, P68431, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539

TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Bazedoxifene

hsa04614

Renin-angiotensin system

1.52E-02

P50052

AGTR2

Bazedoxifene

hsa04623

Cytosolic DNA-sensing pathway

3.84E-05

P01584, P01568, P25963, Q8NHW4

IL1B, IFNA21, NFKBIA, CCL4L2

Bazedoxifene

hsa04625

C-type lectin receptor signaling pathway

4.80E-02

Q9ULY5, P20749, Q14643, P01375, Q13191, Q16539

CLEC4E, BCL3, ITPR1, TNF, CBLB, MAPK14

Bazedoxifene

hsa04640

Hematopoietic cell lineage

3.49E-05

P13612, P21926, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375

ITGA4, CD9, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13612	ITGA4	Integrin alpha-4	-0.771
P52732	KIF11	Kinesin-like protein KIF11	P21926	CD9	CD9 antigen	-0.787
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.762
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.924
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P15144	ANPEP	Aminopeptidase N	0.879
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P11836	MS4A1	B-lymphocyte antigen CD20	-0.705
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.816
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P06493	CDK1	Cyclin-dependent kinase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.732
P06493	CDK1	Cyclin-dependent kinase 1	P06127	CD5	T-cell surface glycoprotein CD5	-0.739
P52732	KIF11	Kinesin-like protein KIF11	P09564	CD7	T-cell antigen CD7	-0.886
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P06493	CDK1	Cyclin-dependent kinase 1	P09564	CD7	T-cell antigen CD7	-0.735
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.73
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774

Bazedoxifene

hsa04650

Natural killer cell mediated cytotoxicity

6.50E-09

P19174, P01375, P78314, P06239, O60880, P20963, Q29983, P10321, P01889, P42338, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715

PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, MICA, HLA-C, HLA-B, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P78314	SH3BP2	SH3 domain-binding protein 2	0.809
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.81
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.77
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
Q9H4A3	WNK1	Serine/threonine-protein kinase WNK1	Q29983	MICA	MHC class I polypeptide-related sequence A	0.774
Q9H4A3	WNK1	Serine/threonine-protein kinase WNK1	P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	0.774
Q9H4A3	WNK1	Serine/threonine-protein kinase WNK1	P01889	HLA-B	HLA class I histocompatibility antigen, B alpha chain	0.774
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.856
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.879
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.893
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Bazedoxifene

hsa04657

IL-17 signaling pathway

2.69E-05

P25963, O00463, Q16539, P49841, P09341, P19875, P14780, P04141, P80188, P01375, P06702

NFKBIA, TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, CSF2, LCN2, TNF, S100A9

Bazedoxifene

hsa04658

Th1 and Th2 cell differentiation

8.90E-06

Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Bazedoxifene

hsa04659

Th17 cell differentiation

1.32E-06

P25963, Q04759, Q16539, P19174, P06239, P42224, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, MAPK14, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q04759	PRKCQ	Protein kinase C theta type	-0.762
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.833
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.762
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q9UL17	TBX21	T-box transcription factor TBX21	-0.861
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.767
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.77

Bazedoxifene

hsa04660

T cell receptor signaling pathway

1.06E-04

P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Bazedoxifene

hsa04664

Fc epsilon RI signaling pathway

2.60E-04

P04141, Q9UQC2, P07948, P19174, P09917, P20292

CSF2, GAB2, LYN, PLCG1, ALOX5, ALOX5AP

Bazedoxifene

hsa04666

Fc gamma R-mediated phagocytosis

9.92E-03

P23528, P06396, O14494, P14598, P49418, P17252

CFL1, GSN, PLPP1, NCF1, AMPH, PRKCA

Bazedoxifene

hsa04668

TNF signaling pathway

3.55E-02

P01375, P18848, P19875, P14780

TNF, ATF4, CXCL2, MMP9

Bazedoxifene

hsa04672

Intestinal immune network for IgA production

1.62E-02

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Bazedoxifene

hsa04713

Circadian entrainment

2.18E-02

P0DP23, P62873, P63218, P50151

CALM1, GNB1, GNG5, GNG10

Bazedoxifene

hsa04714

Thermogenesis

8.70E-07

Q16539, P15336, Q08828, P51828, P63261, P62753, P33121, Q9Y478, P13073, P12074, O15239, Q16718, O14521, P05496

MAPK14, ATF2, ADCY1, ADCY7, ACTG1, RPS6, ACSL1, PRKAB1, COX4I1, COX6A1, NDUFA1, NDUFA5, SDHD, ATP5G1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	Q08828	ADCY1	Adenylate cyclase type 1	0.741
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P62753	RPS6	40S ribosomal protein S6	0.721
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P62753	RPS6	40S ribosomal protein S6	0.722
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.7
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.782
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.709
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.916
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.747
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.842

Bazedoxifene

hsa04721

Synaptic vesicle cycle

3.15E-02

Q13488, P31645

TCIRG1, SLC6A4

Bazedoxifene

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Bazedoxifene

hsa04724

Glutamatergic synapse

3.88E-04

O15399, P62873, P63218, P50151, P15104

GRIN2D, GNB1, GNG5, GNG10, GLUL

Bazedoxifene

hsa04725

Cholinergic synapse

2.17E-02

P51828, P18848, Q13557

ADCY7, ATF4, CAMK2D

Bazedoxifene

hsa04726

Serotonergic synapse

3.80E-02

P62873, P63218, P50151, P09917

GNB1, GNG5, GNG10, ALOX5

Bazedoxifene

hsa04727

GABAergic synapse

2.40E-04

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Bazedoxifene

hsa04728

Dopaminergic synapse

4.78E-02

Q99941, P18848, Q13557

CREBL1, ATF4, CAMK2D

Bazedoxifene

hsa04730

Long-term depression

2.00E-03

Q14344, P08069, P07948

GNA13, IGF1R, LYN

Bazedoxifene

hsa04744

Phototransduction

2.97E-04

P62873, P0DP23

GNB1, CALM1

Bazedoxifene

hsa04750

Inflammatory mediator regulation of TRP channels

7.85E-04

P14778, P01584, Q08828, P51828, P19174, P42338, P24723, Q04759, P0DP23

IL1R1, IL1B, ADCY1, ADCY7, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1

Bazedoxifene

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Bazedoxifene

hsa04911

Insulin secretion

6.24E-05

Q08828, P51828, Q99941, P18848, Q13557

ADCY1, ADCY7, CREBL1, ATF4, CAMK2D

Bazedoxifene

hsa04912

GnRH signaling pathway

6.28E-04

Q08828, P51828, P18848, Q13557, Q16539, Q99759, Q9Y6R4, Q14643, P22694

ADCY1, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K3, MAP3K4, ITPR1, PRKACB

Bazedoxifene

hsa04913

Ovarian steroidogenesis

7.72E-03

P42330, P22694, P08069

AKR1C3, PRKACB, IGF1R

Bazedoxifene

hsa04914

Progesterone-mediated oocyte maturation

2.16E-02

P08069

IGF1R

Bazedoxifene

hsa04915

Estrogen signaling pathway

4.95E-04

Q99941, P18848, Q08828, P51828, P07900, P0DMV8, P11142, P0DP23, Q15788

CREBL1, ATF4, ADCY1, ADCY7, HSP90AA1, HSPA1A, HSPA8, CALM1, NCOA1

Bazedoxifene

hsa04916

Melanogenesis

4.80E-02

P0DP23, Q9UJU2, P17252, P04628

CALM1, LEF1, PRKCA, WNT1

Bazedoxifene

hsa04918

Thyroid hormone synthesis

1.98E-04

P51828, Q99941, P18848, P14625, P02768

ADCY7, CREBL1, ATF4, HSP90B1, ALB

Bazedoxifene

hsa04919

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Bazedoxifene

hsa04920

Adipocytokine signaling pathway

3.24E-04

P25963, Q06124, P33121, Q9Y478, Q04759, Q15831, P20333, Q9Y4H2, P01375

NFKBIA, PTPN11, ACSL1, PRKAB1, PRKCQ, STK11, TNFRSF1B, IRS2, TNF

Bazedoxifene

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Bazedoxifene

hsa04924

Renin secretion

4.04E-02

P22694, P07550

PRKACB, ADRB2

Bazedoxifene

hsa04925

Aldosterone synthesis and secretion

1.69E-03

Q99941, P18848, P51828, Q13557

CREBL1, ATF4, ADCY7, CAMK2D

Bazedoxifene

hsa04926

Relaxin signaling pathway

2.06E-03

Q99941, P18848, P22694, P14780, P51828, P30679

CREBL1, ATF4, PRKACB, MMP9, ADCY7, GNA15

Bazedoxifene

hsa04927

Cortisol synthesis and secretion

2.72E-04

Q99941, P18848, P51828, P22694

CREBL1, ATF4, ADCY7, PRKACB

Bazedoxifene

hsa04928

Parathyroid hormone synthesis, secretion and action

2.17E-02

P51828, Q99941, P18848

ADCY7, CREBL1, ATF4

Bazedoxifene

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Bazedoxifene

hsa04932

Non-alcoholic fatty liver disease

3.23E-06

P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, Q16718, O95298, O14521

TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, SDHD

Bazedoxifene

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.25E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Bazedoxifene

hsa04934

Cushing syndrome

1.12E-03

Q99941, P18848, P51828, Q13557

CREBL1, ATF4, ADCY7, CAMK2D

Bazedoxifene

hsa04935

Growth hormone synthesis, secretion and action

2.72E-02

P51828, Q99941, P18848

ADCY7, CREBL1, ATF4

Bazedoxifene

hsa04940

Type I diabetes mellitus

4.29E-04

P48023, P01889, P10321, P01375

FASLG, HLA-B, HLA-C, TNF

Bazedoxifene

hsa04962

Vasopressin-regulated water reabsorption

7.22E-03

P52566, P62491

ARHGDIB, RAB11A

Bazedoxifene

hsa04970

Salivary secretion

2.43E-03

P07550, Q08828, P51828, P22694, P0DP23, P49913

ADRB2, ADCY1, ADCY7, PRKACB, CALM1, CAMP

Bazedoxifene

hsa04971

Gastric acid secretion

4.44E-02

P51828, P15311

ADCY7, VIL2

Bazedoxifene

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Bazedoxifene

hsa04975

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Bazedoxifene

hsa04976

Bile secretion

1.90E-04

O43315, Q08828, P51828, P22694, P08183, Q14032

AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAAT

Bazedoxifene

hsa05010

Alzheimer disease

1.19E-03

O15239, P05496, P13073, P12074, O15399, Q9NZJ5, Q13564, P01584, P18848, Q71U36, P09603, P05141, P21796, P28070, P43686

NDUFA1, ATP5G1, COX4I1, COX6A1, GRIN2D, EIF2AK3, APPBP1, IL1B, ATF4, TUBA1A, CSF1, SLC25A5, VDAC1, PSMB4, PSMC4

Bazedoxifene

hsa05012

Parkinson disease

1.23E-04

O15239, P13073, P12074, P05496, P05141, P60604, P18848, P28070, P43686, P19174, P0DP23, Q13557, Q71U36, Q13509, P68371

NDUFA1, COX4I1, COX6A1, ATP5G1, SLC25A5, UBE2G2, ATF4, PSMB4, PSMC4, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3, TUBB2C

Bazedoxifene

hsa05014

Amyotrophic lateral sclerosis

2.84E-03

P20333, O15239, P13073, P12074, P05496, P18848, P28070, P43686, P35658, Q9UBU9

TNFRSF1B, NDUFA1, COX4I1, COX6A1, ATP5G1, ATF4, PSMB4, PSMC4, NUP214, NXF1

Bazedoxifene

hsa05016

Huntington disease

3.22E-04

O15239, O95298, P13073, P12074, P05496, P24928, P30876, P62487, P05141, O75460, P28070, P43686, O00232

NDUFA1, NDUFC2, COX4I1, COX6A1, ATP5G1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMC4, PSMD12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.916
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.782
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.842
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.796
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.754
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P05141	SLC25A5	ADP/ATP translocase 2	0.75
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P28070	PSMB4	Proteasome subunit beta type-4	0.735
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.804
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703

Bazedoxifene

hsa05020

Prion disease

2.54E-05

P01584, P46531, O15239, Q16718, O14521, P05496, P13073, P12074, P18848, P05141, P28070, P43686, P49841, P51636, Q16539

IL1B, NOTCH1, NDUFA1, NDUFA5, SDHD, ATP5G1, COX4I1, COX6A1, ATF4, SLC25A5, PSMB4, PSMC4, GSK3B, CAV2, MAPK14

Bazedoxifene

hsa05022

Pathways of neurodegeneration - multiple diseases

7.82E-05

P49841, O15239, Q16718, O14521, P13073, P12074, P05496, P18848, Q13561, P05141, P20333, Q16539, P01584, Q08752, Q13557, P28070, P43686

GSK3B, NDUFA1, NDUFA5, SDHD, COX4I1, COX6A1, ATP5G1, ATF4, DCTN2, SLC25A5, TNFRSF1B, MAPK14, IL1B, PPID, CAMK2D, PSMB4, PSMC4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.916
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.7
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.782
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.842
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.776
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P05141	SLC25A5	ADP/ATP translocase 2	0.75
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	0.711
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P01584	IL1B	Interleukin-1 beta	0.827
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.784
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P28070	PSMB4	Proteasome subunit beta type-4	0.735
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.804

Bazedoxifene

hsa05030

Cocaine addiction

4.87E-02

Q99941, P18848

CREBL1, ATF4

Bazedoxifene

hsa05031

Amphetamine addiction

8.84E-04

Q13557, P22694, Q99941, P18848, Q13547

CAMK2D, PRKACB, CREBL1, ATF4, HDAC1

Bazedoxifene

hsa05032

Morphine addiction

7.62E-04

P62873, P63218, P50151, Q13370, Q07343, P43250

GNB1, GNG5, GNG10, PDE3B, PDE4B, GRK6

Bazedoxifene

hsa05034

Alcoholism

3.30E-02

Q96RR4, P84243

CAMKK2, H3F3A

Bazedoxifene

hsa05110

Vibrio cholerae infection

4.50E-03

Q13488, P17252, P19174, P60709

TCIRG1, PRKCA, PLCG1, ACTB

Bazedoxifene

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

7.88E-05

P25963, Q13488, P09341, P19875, P19174, P25024, P25025, P07948

NFKBIA, TCIRG1, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN

Bazedoxifene

hsa05130

Pathogenic Escherichia coli infection

1.44E-03

Q71U36, P16333, Q92974, Q13509, P68371, P63261, Q14344, P25963, Q06124, O95487

TUBA1A, NCK1, ARHGEF2, TUBB3, TUBB2C, ACTG1, GNA13, NFKBIA, PTPN11, SEC24B

Bazedoxifene

hsa05132

Salmonella infection

3.14E-04

P51617, P25963, P08238, Q9UJU2, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q71U36, Q13509, P68371, P49754

IRAK1, NFKBIA, HSP90AB1, LEF1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41

Bazedoxifene

hsa05133

Pertussis

2.95E-03

P0DP23, P0C0L4

CALM1, C4A

Bazedoxifene

hsa05134

Legionellosis

1.05E-04

P01584, P25963, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875

IL1B, NFKBIA, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2

Bazedoxifene

hsa05140

Leishmaniasis

1.63E-06

P13612, O75015, P14598, P11215, P42224, P13765, O60603, P25963, P01375, P29350, Q16539, P51617, Q15080

ITGA4, FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MAPK14, IRAK1, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13612	ITGA4	Integrin alpha-4	-0.771
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.893
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P14598	NCF1	Neutrophil cytosol factor 1	0.711
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11215	ITGAM	Integrin alpha-M	-0.78
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.714
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.73
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O60603	TLR2	Toll-like receptor 2	0.867
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.865
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P01375	TNF	Tumor necrosis factor	0.711
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	0.856
P09960	LTA4H	Leukotriene A-4 hydrolase	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	0.808
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.833
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.71
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.764

Bazedoxifene

hsa05143

African trypanosomiasis

3.01E-03

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Bazedoxifene

hsa05144

Malaria

9.55E-04

P60033, O60603, P01375, P35443, P26718

CD81, TLR2, TNF, THBS4, KLRK1

Bazedoxifene

hsa05145

Toxoplasmosis

2.78E-02

P25963, P10415, Q13489

NFKBIA, BCL2, BIRC3

Bazedoxifene

hsa05146

Amoebiasis

8.90E-07

P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311

CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSG

Bazedoxifene

hsa05152

Tuberculosis

8.59E-04

Q13488, Q99437, P13473, P0DP23, P42224, P48382, P25208, O60603, P01375, P10415, P13765, P01568, P49913, Q9UDY8, P51617

TCIRG1, ATP6V0B, LAMP2, CALM1, STAT1, RFX5, NFYB, TLR2, TNF, BCL2, HLA-DOB, IFNA21, CAMP, MALT1, IRAK1

Bazedoxifene

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Bazedoxifene

hsa05161

Hepatitis B

9.85E-04

Q99941, P18848, P25963, Q13485, P10415, P27348, P84022

CREBL1, ATF4, NFKBIA, SMAD4, BCL2, YWHAQ, SMAD3

Bazedoxifene

hsa05162

Measles

3.18E-02

P23458, P0DMV8, P01584, Q9NP90

JAK1, HSPA1A, IL1B, RAB9B

Bazedoxifene

hsa05163

Human cytomegalovirus infection

6.65E-05

P25963, P62873, P63218, P50151, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P01584, P61073, Q13651, P30101, P01568

NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, CXCR4, IL10RA, PDIA3, IFNA21

Bazedoxifene

hsa05167

Kaposi sarcoma-associated herpesvirus infection

1.51E-06

P01568, P42224, P25963, P01889, P10321, P62873, P63218, P50151, P19174, P07948, Q29983, P04141, P0DP23

IFNA21, STAT1, NFKBIA, HLA-B, HLA-C, GNB1, GNG5, GNG10, PLCG1, LYN, MICA, CSF2, CALM1

Bazedoxifene

hsa05168

Herpes simplex virus 1 infection

4.84E-04

P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, P30101, Q13398, Q9HCX3, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212

Bazedoxifene

hsa05169

Epstein-Barr virus infection

4.39E-02

P01889, P10321

HLA-B, HLA-C

Bazedoxifene

hsa05170

Human immunodeficiency virus 1 infection

7.42E-07

P01889, P10321, P62873, P63218, P50151, P0DP23, P01375, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, P19174, P23528, Q9NQU5, P10415, Q93034, Q9Y6Q5, P20333

HLA-B, HLA-C, GNB1, GNG5, GNG10, CALM1, TNF, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, PLCG1, CFL1, PAK6, BCL2, CUL5, AP1M2, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9H4A3	WNK1	Serine/threonine-protein kinase WNK1	P01889	HLA-B	HLA class I histocompatibility antigen, B alpha chain	0.774
Q9H4A3	WNK1	Serine/threonine-protein kinase WNK1	P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	0.774
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.798
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P10415	BCL2	Apoptosis regulator Bcl-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.777
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P10415	BCL2	Apoptosis regulator Bcl-2	P0DP23	CALM1	Calmodulin-1	-0.772
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P01375	TNF	Tumor necrosis factor	0.711
P10415	BCL2	Apoptosis regulator Bcl-2	P17252	PRKCA	Protein kinase C alpha type	0.844
P10415	BCL2	Apoptosis regulator Bcl-2	O00463	TRAF5	TNF receptor-associated factor 5	0.773
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
P10415	BCL2	Apoptosis regulator Bcl-2	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.858
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P10415	BCL2	Apoptosis regulator Bcl-2	P01568	IFNA21	Interferon alpha-21	0.721
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.71
P10415	BCL2	Apoptosis regulator Bcl-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.807
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.865
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P10415	BCL2	Apoptosis regulator Bcl-2	O60603	TLR2	Toll-like receptor 2	-0.884
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	Q13315	ATM	Serine-protein kinase ATM	-0.71
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P10415	BCL2	Apoptosis regulator Bcl-2	P23528	CFL1	Cofilin-1	0.741
Q9H4A3	WNK1	Serine/threonine-protein kinase WNK1	Q9NQU5	PAK6	Serine/threonine-protein kinase PAK 6	0.75
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	Q9NQU5	PAK6	Serine/threonine-protein kinase PAK 6	0.924
P10415	BCL2	Apoptosis regulator Bcl-2	P10415	BCL2	Apoptosis regulator Bcl-2	1
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	Q93034	CUL5	Cullin-5	-0.766
P10415	BCL2	Apoptosis regulator Bcl-2	Q93034	CUL5	Cullin-5	0.704
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.709
P10415	BCL2	Apoptosis regulator Bcl-2	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.901
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	0.778

Bazedoxifene

hsa05171

Coronavirus disease - COVID-19

1.05E-06

P01375, P01584, P51617, P25963, P42224, P23396, P62753, P62249, P39019, P42677, P62906, Q02878, P62917, P27635, Q07020, P46776, P61513, P63173, P05386, P04141

TNF, IL1B, IRAK1, NFKBIA, STAT1, RPS3, RPS6, RPS16, RPS19, RPS27, RPL10A, RPL6, RPL8, RPL10, RPL18, RPL27A, RPL37A, RPL38, RPLP1, CSF2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P01375	TNF	Tumor necrosis factor	0.711
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P01584	IL1B	Interleukin-1 beta	0.827
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.71
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.865
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.714
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P23396	RPS3	40S ribosomal protein S3	0.777
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P23396	RPS3	40S ribosomal protein S3	0.701
P14625	HSP90B1	Endoplasmin	P23396	RPS3	40S ribosomal protein S3	0.8
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P62753	RPS6	40S ribosomal protein S6	0.721
P14625	HSP90B1	Endoplasmin	P62753	RPS6	40S ribosomal protein S6	0.738
P14625	HSP90B1	Endoplasmin	P62249	RPS16	40S ribosomal protein S16	0.77
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P39019	RPS19	40S ribosomal protein S19	0.7
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P39019	RPS19	40S ribosomal protein S19	0.733
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P42677	RPS27	40S ribosomal protein S27	0.738
P14625	HSP90B1	Endoplasmin	P62906	RPL10A	60S ribosomal protein L10a	0.718
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	Q02878	RPL6	60S ribosomal protein L6	0.753
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P62917	RPL8	60S ribosomal protein L8	0.763
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P62917	RPL8	60S ribosomal protein L8	0.814
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P27635	RPL10	60S ribosomal protein L10	0.708
P14625	HSP90B1	Endoplasmin	P27635	RPL10	60S ribosomal protein L10	0.715
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	Q07020	RPL18	60S ribosomal protein L18	0.732
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	Q07020	RPL18	60S ribosomal protein L18	0.722
P14625	HSP90B1	Endoplasmin	Q07020	RPL18	60S ribosomal protein L18	0.724
P14625	HSP90B1	Endoplasmin	P46776	RPL27A	60S ribosomal protein L27a	0.741
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P61513	RPL37A	60S ribosomal protein L37a	0.787
P14625	HSP90B1	Endoplasmin	P61513	RPL37A	60S ribosomal protein L37a	0.8
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P63173	RPL38	60S ribosomal protein L38	0.742
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P05386	RPLP1	60S acidic ribosomal protein P1	0.777
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P05386	RPLP1	60S acidic ribosomal protein P1	0.781
Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	P04141	CSF2	Granulocyte-macrophage colony-stimulating factor	-0.749

Bazedoxifene

hsa05200

Pathways in cancer

1.99E-03

P08238, P42224, P25963, P19174, P43246, P84022, P20585, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784

HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, MSH3, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB

Bazedoxifene

hsa05202

Transcriptional misregulation in cancer

1.40E-05

Q12778, Q15532, P41732, P14780, P27930, P14923, Q16548, Q13489, Q13077, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522

FOXO1, SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, BIRC3, TRAF1, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10415	BCL2	Apoptosis regulator Bcl-2	Q12778	FOXO1	Forkhead box protein O1	0.794
P10415	BCL2	Apoptosis regulator Bcl-2	Q15532	SS18	Protein SSXT	0.877
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P41732	TSPAN7	Tetraspanin-7	0.703
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P14780	MMP9	Matrix metalloproteinase-9	0.942
P10415	BCL2	Apoptosis regulator Bcl-2	P14780	MMP9	Matrix metalloproteinase-9	-0.765
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.924
P10415	BCL2	Apoptosis regulator Bcl-2	P14923	JUP	Junction plakoglobin	0.861
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16548	BCL2A1	Bcl-2-related protein A1	0.913
P10415	BCL2	Apoptosis regulator Bcl-2	Q16548	BCL2A1	Bcl-2-related protein A1	-0.746
P10415	BCL2	Apoptosis regulator Bcl-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.848
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q13077	TRAF1	TNF receptor-associated factor 1	-0.712
P10415	BCL2	Apoptosis regulator Bcl-2	Q13077	TRAF1	TNF receptor-associated factor 1	0.816
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P10415	BCL2	Apoptosis regulator Bcl-2	P35226	BMI1	Polycomb complex protein BMI-1	0.78
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P10415	BCL2	Apoptosis regulator Bcl-2	P35226	BMI1	Polycomb complex protein BMI-1	0.78
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P05164	MPO	Myeloperoxidase	0.711
P10415	BCL2	Apoptosis regulator Bcl-2	P05164	MPO	Myeloperoxidase	-0.81
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P12838	DEFA4	Neutrophil defensin 4	0.767
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P08246	ELA2	Neutrophil elastase	0.703
P10415	BCL2	Apoptosis regulator Bcl-2	P08246	ELA2	Neutrophil elastase	-0.942
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.765
P10415	BCL2	Apoptosis regulator Bcl-2	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.766
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P41182	BCL6	B-cell lymphoma 6 protein	0.9
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q13547	HDAC1	Histone deacetylase 1	-0.742
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q92769	HDAC2	Histone deacetylase 2	-0.746
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P12980	LYL1	Protein lyl-1	0.782
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.801

Bazedoxifene

hsa05203

Viral carcinogenesis

2.50E-04

Q99941, P18848, P27348, P06396, P01889, P10321, P61978

CREBL1, ATF4, YWHAQ, GSN, HLA-B, HLA-C, HNRPK

Bazedoxifene

hsa05205

Proteoglycans in cancer

5.76E-04

Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P01375, P08069, P23588, P04628, Q13635, P22694, P08962

TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, TNF, IGF1R, EIF4B, WNT1, PTCH1, PRKACB, CD63

Bazedoxifene

hsa05210

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Bazedoxifene

hsa05211

Renal cell carcinoma

1.06E-02

Q06124, Q99814

PTPN11, EPAS1

Bazedoxifene

hsa05212

Pancreatic cancer

9.73E-04

P42224, P37173, P84022, Q13485, O75293

STAT1, TGFBR2, SMAD3, SMAD4, GADD45B

Bazedoxifene

hsa05214

Glioma

7.45E-03

P08069, P0DP23, P19174, O75293

IGF1R, CALM1, PLCG1, GADD45B

Bazedoxifene

hsa05215

Prostate cancer

3.72E-03

P08069, P18848, P14625

IGF1R, ATF4, HSP90B1

Bazedoxifene

hsa05216

Thyroid cancer

3.80E-02

P01106, O75293

MYC, GADD45B

Bazedoxifene

hsa05218

Melanoma

6.63E-03

P08069

IGF1R

Bazedoxifene

hsa05220

Chronic myeloid leukemia

1.25E-02

Q13485, P25963, P84022

SMAD4, NFKBIA, SMAD3

Bazedoxifene

hsa05222

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Bazedoxifene

hsa05223

Non-small cell lung cancer

1.94E-03

P17252, O43524, P19174, P10826, Q9HC35, O75293

PRKCA, FOXO3, PLCG1, RARB, EML4, GADD45B

Bazedoxifene

hsa05224

Breast cancer

1.49E-02

P08069

IGF1R

Bazedoxifene

hsa05225

Hepatocellular carcinoma

1.33E-02

P08069

IGF1R

Bazedoxifene

hsa05226

Gastric cancer

2.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Bazedoxifene

hsa05231

Choline metabolism in cancer

3.99E-02

P19174, P23743, O14494, P17252

PLCG1, DGKA, PLPP1, PRKCA

Bazedoxifene

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

2.99E-04

P42338, P19174, P07766, P20963, P06239, Q04759, Q9HC35, P01730

PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQ, EML4, CD4

Bazedoxifene

hsa05320

Autoimmune thyroid disease

5.64E-04

P13765, P29965, P01889, P10321, P01568, P10747

HLA-DOB, CD40LG, HLA-B, HLA-C, IFNA21, CD28

Bazedoxifene

hsa05321

Inflammatory bowel disease

1.48E-04

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Bazedoxifene

hsa05330

Allograft rejection

4.29E-04

P01889, P10321, P48023, P01375

HLA-B, HLA-C, FASLG, TNF

Bazedoxifene

hsa05332

Graft-versus-host disease

7.28E-06

P13765, P48023, P01889, P10321, P01375, P26715, Q13241

HLA-DOB, FASLG, HLA-B, HLA-C, TNF, KLRC1, KLRD1

Bazedoxifene

hsa05340

Primary immunodeficiency

1.28E-03

P01730, P11912, P07766, P06239

CD4, CD79A, CD3E, LCK

Bazedoxifene

hsa05410

Hypertrophic cardiomyopathy

1.73E-02

P26012, P09493

ITGB8, TPM1

Bazedoxifene

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

8.94E-03

P15924, P26012

DSP, ITGB8

Bazedoxifene

hsa05415

Diabetic cardiomyopathy

4.37E-06

P17252, P05141, P14598, Q15080, O15239, Q16718, O14521, P05496, P13073, P12074, Q16539, P49841, Q13557, P04406

PRKCA, SLC25A5, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, ATP5G1, COX4I1, COX6A1, MAPK14, GSK3B, CAMK2D, GAPDH

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P09960	LTA4H	Leukotriene A-4 hydrolase	P17252	PRKCA	Protein kinase C alpha type	-0.732
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P05141	SLC25A5	ADP/ATP translocase 2	0.75
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.916
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.842
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.7
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.782
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P46531	NOTCH1	Neurogenic locus notch homolog protein 1	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.784
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P09960	LTA4H	Leukotriene A-4 hydrolase	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.725