PharmaCoNets of Baricitinib (SPCN: 53.08 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Baricitinibhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Baricitinibhsa00280Valine, leucine and isoleucine degradation3.41E-034P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Baricitinibhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Baricitinibhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Baricitinibhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Baricitinibhsa00630Glyoxylate and dicarboxylate metabolism2.27E-052P40925, P15104MDH1, GLULMore
Baricitinibhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Baricitinibhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Baricitinibhsa01522Endocrine resistance4.74E-023P22694, P10415, Q13323PRKACB, BCL2, BIKMore
Baricitinibhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Baricitinibhsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Baricitinibhsa03013RNA transport4.13E-026Q09161, P35658, P47813, Q14152, O75822, P51114NCBP1, NUP214, EIF1AX, EIF3A, EIF3J, FXR1More
Baricitinibhsa03020RNA polymerase2.61E-033P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Baricitinibhsa03040Spliceosome8.73E-048Q14562, O43143, O60508, P08579, Q07955, Q01130, Q13243, O43447DHX8, DHX15, CDC40, SNRPB2, SFRS1, SFRS2, SFRS5, PPIHMore
Baricitinibhsa03060Protein export4.42E-022P37108, Q15005SRP14, SPCS2More
Baricitinibhsa03320PPAR signaling pathway4.33E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Baricitinibhsa04024cAMP signaling pathway4.38E-024P42338, P0DP23, Q13370, Q13009PIK3CB, CALM1, PDE3B, TIAM1More
Baricitinibhsa04064NF-kappa B signaling pathway2.35E-024P01584, P63279, Q8NHW4, Q9NQC7IL1B, UBE2I, CCL4L2, CYLDMore
Baricitinibhsa04070Phosphatidylinositol signaling system4.86E-023P0DP23, P42338, P27987CALM1, PIK3CB, ITPKBMore
Baricitinibhsa04080Neuroactive ligand-receptor interaction4.90E-036P08311, Q15722, P21453, Q9H228, O00398, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, ADRB2More
Baricitinibhsa04114Oocyte meiosis6.23E-035Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Baricitinibhsa04140Autophagy - animal4.74E-023P22694, Q14643, P10415PRKACB, ITPR1, BCL2More
Baricitinibhsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Baricitinibhsa04142Lysosome1.46E-027P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Baricitinibhsa04144Endocytosis1.67E-028P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12More
Baricitinibhsa04213Longevity regulating pathway - multiple species2.82E-023Q08828, P51828, P0DMV8ADCY1, ADCY7, HSPA1AMore
Baricitinibhsa04217Necroptosis4.42E-046P07900, P15104, P05141, P01584, P0C0S5, Q13557HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2DMore
Baricitinibhsa04270Vascular smooth muscle contraction6.96E-036P0DP23, Q08828, P51828, P35579, P35749, P35318CALM1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Baricitinibhsa04340Hedgehog signaling pathway9.74E-033P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Baricitinibhsa04360Axon guidance1.71E-024P20827, O95631, P42338, P23528EFNA1, NTN1, PIK3CB, CFL1More
Baricitinibhsa04370VEGF signaling pathway3.06E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Baricitinibhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Baricitinibhsa04540Gap junction2.86E-023P22694, P68371, Q14643PRKACB, TUBB2C, ITPR1More
Baricitinibhsa04550Signaling pathways regulating pluripotency of stem cells4.73E-023Q13873, Q02750, Q86SE9BMPR2, MAP2K1, PCGF5More
Baricitinibhsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Baricitinibhsa04613Neutrophil extracellular trap formation1.73E-024Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Baricitinibhsa04623Cytosolic DNA-sensing pathway1.65E-022P01584, Q8NHW4IL1B, CCL4L2More
Baricitinibhsa04650Natural killer cell mediated cytotoxicity3.73E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Baricitinibhsa04657IL-17 signaling pathway4.87E-022P07900, P01584HSP90AA1, IL1BMore
Baricitinibhsa04659Th17 cell differentiation4.38E-024P42224, P14784, P40189, P08238STAT1, IL2RB, IL6ST, HSP90AB1More
Baricitinibhsa04662B cell receptor signaling pathway1.49E-035P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Baricitinibhsa04664Fc epsilon RI signaling pathway2.32E-023P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Baricitinibhsa04666Fc gamma R-mediated phagocytosis3.08E-023P42338, P23528, P14598PIK3CB, CFL1, NCF1More
Baricitinibhsa04720Long-term potentiation2.85E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Baricitinibhsa04724Glutamatergic synapse5.94E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Baricitinibhsa04725Cholinergic synapse3.62E-036P22694, Q14643, P63218, P50151, P42338, P10415PRKACB, ITPR1, GNG5, GNG10, PIK3CB, BCL2More
Baricitinibhsa04727GABAergic synapse1.63E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Baricitinibhsa04750Inflammatory mediator regulation of TRP channels4.01E-024P01584, Q08828, P51828, P0DP23IL1B, ADCY1, ADCY7, CALM1More
Baricitinibhsa04913Ovarian steroidogenesis2.72E-022P42330, P22694AKR1C3, PRKACBMore
Baricitinibhsa04914Progesterone-mediated oocyte maturation9.70E-047Q17RY0, P42338, Q13370, Q9Y6D9, P08238, P51812, Q02750CPEB4, PIK3CB, PDE3B, MAD1L1, HSP90AB1, RPS6KA3, MAP2K1More
Baricitinibhsa04915Estrogen signaling pathway3.17E-025Q08828, P51828, P0DMV8, P0DP23, Q15788ADCY1, ADCY7, HSPA1A, CALM1, NCOA1More
Baricitinibhsa04924Renin secretion2.65E-045P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Baricitinibhsa04926Relaxin signaling pathway5.70E-035P42338, P63218, P50151, P49767, P49407PIK3CB, GNG5, GNG10, VEGFC, ARRB1More
Baricitinibhsa04927Cortisol synthesis and secretion2.72E-022Q14643, P22694ITPR1, PRKACBMore
Baricitinibhsa04928Parathyroid hormone synthesis, secretion and action1.02E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Baricitinibhsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Baricitinibhsa04932Non-alcoholic fatty liver disease5.01E-048O43521, P18848, O75460, P01584, P13073, P12074, O15239, O95298BCL2L11, ATF4, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2More
Baricitinibhsa04934Cushing syndrome4.74E-023Q14643, P22694, P04628ITPR1, PRKACB, WNT1More
Baricitinibhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Baricitinibhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Baricitinibhsa04970Salivary secretion2.62E-036P07550, Q08828, P51828, P22694, Q14643, P0DP23ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, CALM1More
Baricitinibhsa04976Bile secretion4.78E-023Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Baricitinibhsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Baricitinibhsa05016Huntington disease2.72E-0311O15239, O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232NDUFA1, NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12More
Baricitinibhsa05020Prion disease3.37E-037P13591, P01584, P11142, O15239, P13073, P18848, P05141NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5More
Baricitinibhsa05022Pathways of neurodegeneration - multiple diseases3.80E-026O15239, P13073, P18848, P05141, P01584, Q13557NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2DMore
Baricitinibhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Baricitinibhsa05100Bacterial invasion of epithelial cells2.85E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Baricitinibhsa05133Pertussis4.20E-021P0C0L4C4AMore
Baricitinibhsa05134Legionellosis1.18E-035P01584, Q9NR31, P68104, P0DMV8, P11142IL1B, SAR1A, EEF1A1, HSPA1A, HSPA8More
Baricitinibhsa05135Yersinia infection3.29E-024Q05397, P51812, Q02750, Q96JJ3PTK2, RPS6KA3, MAP2K1, ELMO2More
Baricitinibhsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Baricitinibhsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Baricitinibhsa05150Staphylococcus aureus infection2.44E-024P21462, Q14532, P59665, P59666FPR1, KRT32, DEFA1; DEFA1B, DEFA3More
Baricitinibhsa05162Measles3.74E-035P23458, P0DMV8, P11142, P01584, Q9NP90JAK1, HSPA1A, HSPA8, IL1B, RAB9BMore
Baricitinibhsa05163Human cytomegalovirus infection3.31E-027P0DP23, Q8NHW4, Q08828, P51828, P23458, P01584, Q13651CALM1, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, IL10RAMore
Baricitinibhsa05168Herpes simplex virus 1 infection1.15E-028P42224, Q07955, Q01130, Q13243, P42338, Q13398, Q03923, Q9UDV6STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF211, ZNF85, ZNF212More
Baricitinibhsa05169Epstein-Barr virus infection3.72E-026Q13547, P42338, P07948, Q13761, O75293, P07766HDAC1, PIK3CB, LYN, RUNX3, GADD45B, CD3EMore
Baricitinibhsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Baricitinibhsa05200Pathways in cancer3.92E-029P42338, P08238, P42224, P43246, P14923, O75293, P0DP23, P14784, P40189PIK3CB, HSP90AB1, STAT1, MSH2, JUP, GADD45B, CALM1, IL2RB, IL6STMore
Baricitinibhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Baricitinibhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Baricitinibhsa05212Pancreatic cancer1.72E-023P42338, P42224, O75293PIK3CB, STAT1, GADD45BMore
Baricitinibhsa05214Glioma1.72E-023P0DP23, P42338, O75293CALM1, PIK3CB, GADD45BMore
Baricitinibhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Baricitinibhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Baricitinibhsa05415Diabetic cardiomyopathy2.87E-024P05141, O15239, P13073, Q13557SLC25A5, NDUFA1, COX4I1, CAMK2DMore
Baricitinibhsa05418Fluid shear stress and atherosclerosis3.73E-024P42338, P14598, P0DP23, P08238PIK3CB, NCF1, CALM1, HSP90AB1More

Community members of Baricitinib (SDC: 4.99)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P23458JAK1TyrosineNoneprotein kinase JAK1Reported10.55460.921113.1195
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P21453S1PR1Sphingosine 1Nonephosphate receptor 1Predicted10.14340.38470.2211.0621
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P26358DNMT1DNAPredicted00.34040.28090.26590.998
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
JAK1P23458IC500.99
JAK1P23458IC504
JAK1P23458IC506