PharmaCoNets

PharmaCoNets of Balsalazide (S_PCN: 43.69 )

Balsalazide regulated-network (S_DN: 11.41)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Balsalazide

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Balsalazide

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Balsalazide

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Balsalazide

hsa00600

Sphingolipid metabolism

4.50E-02

P15289

ARSA

Balsalazide

hsa00920

Sulfur metabolism

3.18E-02

Q16762

TST

Balsalazide

hsa00970

Aminoacyl-tRNA biosynthesis

3.78E-02

O95363, Q15046

FARS2, KARS

Balsalazide

hsa01522

Endocrine resistance

4.55E-02

P14780, P22694, Q9UM47, P10415, Q13323

MMP9, PRKACB, NOTCH3, BCL2, BIK

Balsalazide

hsa02010

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Balsalazide

hsa03040

Spliceosome

1.28E-05

O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Balsalazide

hsa04014

Ras signaling pathway

2.36E-02

P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Balsalazide

hsa04015

Rap1 signaling pathway

2.75E-04

P20827, P49767, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P08514, P19174

EFNA1, VEGFC, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, ITGA2B, PLCG1

Balsalazide

hsa04022

cGMP-PKG signaling pathway

1.05E-02

P24844, Q8WYR1, Q15746

MYL9, PIK3R5, MYLK

Balsalazide

hsa04024

cAMP signaling pathway

1.40E-02

P48058, P25116, P24844

GRIA4, F2R, MYL9

Balsalazide

hsa04062

Chemokine signaling pathway

9.23E-03

P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1

FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5

Balsalazide

hsa04064

NF-kappa B signaling pathway

1.47E-04

P10415, Q13489, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q13315, P24522, P09341

BCL2, BIRC3, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, ATM, GADD45A, CXCL1

Balsalazide

hsa04071

Sphingolipid signaling pathway

3.57E-05

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2

Balsalazide

hsa04080

Neuroactive ligand-receptor interaction

1.81E-03

P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550

CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2

Balsalazide

hsa04120

Ubiquitin mediated proteolysis

1.68E-02

O00762, Q14139

UBE2C, UBE4A

Balsalazide

hsa04122

Sulfur relay system

3.18E-02

Q16762

TST

Balsalazide

hsa04140

Autophagy - animal

3.94E-03

P22694, Q14643, P10415, Q9H1Y0, Q04759

PRKACB, ITPR1, BCL2, ATG5, PRKCQ

Balsalazide

hsa04144

Endocytosis

4.10E-02

O75351, P62491, Q14161

VPS4B, RAB11A, GIT2

Balsalazide

hsa04145

Phagosome

1.45E-03

O75015, Q15080, P14598, Q13509, P05164, O60603, P35443, P13765

FCGR3B, NCF4, NCF1, TUBB3, MPO, TLR2, THBS4, HLA-DOB

Balsalazide

hsa04151

PI3K-Akt signaling pathway

3.70E-02

P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281

PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3

Balsalazide

hsa04210

Apoptosis

3.44E-02

Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643

ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1

Balsalazide

hsa04270

Vascular smooth muscle contraction

4.65E-02

Q15746, P24844

MYLK, MYL9

Balsalazide

hsa04340

Hedgehog signaling pathway

2.62E-03

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Balsalazide

hsa04360

Axon guidance

4.04E-02

P16333, P20827, O95631, P42338, P07332, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1

Balsalazide

hsa04371

Apelin signaling pathway

1.00E-02

P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3

Balsalazide

hsa04510

Focal adhesion

3.36E-02

P08514, Q15746, P24844

ITGA2B, MYLK, MYL9

Balsalazide

hsa04512

ECM-receptor interaction

2.02E-03

P07359, P08514

GP1BA, ITGA2B

Balsalazide

hsa04514

Cell adhesion molecules

9.16E-04

P16109, P56750, O00501

SELP, CLDN17, CLDN5

Balsalazide

hsa04530

Tight junction

2.96E-07

Q8TEU7, P16989, P56750, O00501, Q14247, P24844

RAPGEF6, CSDA, CLDN17, CLDN5, CTTN, MYL9

Balsalazide

hsa04610

Complement and coagulation cascades

8.94E-05

P25116, P09871, P0C0L4, P10909

F2R, C1S, C4A, CLU

Balsalazide

hsa04611

Platelet activation

2.54E-09

P25116, P08514, Q15746, Q8WYR1, P07359

F2R, ITGA2B, MYLK, PIK3R5, GP1BA

Balsalazide

hsa04612

Antigen processing and presentation

3.22E-03

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Balsalazide

hsa04613

Neutrophil extracellular trap formation

2.34E-05

P17252, P16109, O60603, P05164, P08246, Q9UM07, Q6FI13, O60814, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359, O43315, Q16539

PRKCA, SELP, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, H2BC12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778

Balsalazide

hsa04621

NOD-like receptor signaling pathway

2.62E-02

Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838

MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4

Balsalazide

hsa04650

Natural killer cell mediated cytotoxicity

2.96E-02

O60880, P20963, Q13241, P26718, P26717, P26715

SH2D1A, CD247, KLRD1, KLRK1, KLRC2, KLRC1

Balsalazide

hsa04657

IL-17 signaling pathway

3.91E-02

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Balsalazide

hsa04658

Th1 and Th2 cell differentiation

5.80E-05

Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765

PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOB

Balsalazide

hsa04659

Th17 cell differentiation

9.58E-04

Q04759, P19174, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

PRKCQ, PLCG1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Balsalazide

hsa04660

T cell receptor signaling pathway

1.40E-04

P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841

TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3B

Balsalazide

hsa04662

B cell receptor signaling pathway

1.74E-02

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Balsalazide

hsa04664

Fc epsilon RI signaling pathway

2.47E-02

P42338, P07948, P19174, P09917

PIK3CB, LYN, PLCG1, ALOX5

Balsalazide

hsa04666

Fc gamma R-mediated phagocytosis

3.08E-02

O75015, P06396, O14494, P14598, P17252

FCGR3B, GSN, PLPP1, NCF1, PRKCA

Balsalazide

hsa04710

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Balsalazide

hsa04724

Glutamatergic synapse

2.94E-02

P48058, Q9NSB8

GRIA4, HOMER2

Balsalazide

hsa04810

Regulation of actin cytoskeleton

1.23E-04

P24844, Q15746, P08514, P25116

MYL9, MYLK, ITGA2B, F2R

Balsalazide

hsa04920

Adipocytokine signaling pathway

4.31E-02

Q9Y478, Q96RR4

PRKAB1, CAMKK2

Balsalazide

hsa04921

Oxytocin signaling pathway

6.37E-03

Q15746, P24844, Q8WYR1

MYLK, MYL9, PIK3R5

Balsalazide

hsa04922

Glucagon signaling pathway

4.23E-02

P22694, P06737, Q12778, Q14643

PRKACB, PYGL, FOXO1, ITPR1

Balsalazide

hsa04924

Renin secretion

1.04E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Balsalazide

hsa04928

Parathyroid hormone synthesis, secretion and action

4.23E-02

Q14643, P22694, P23771, P10415

ITPR1, PRKACB, GATA3, BCL2

Balsalazide

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.21E-02

P84022, Q13485, P42338, P49767, P19174

SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1

Balsalazide

hsa04940

Type I diabetes mellitus

4.18E-02

P10747, P13765, P01375

CD28, HLA-DOB, TNF

Balsalazide

hsa04962

Vasopressin-regulated water reabsorption

1.80E-02

P62491, P46459

RAB11A, NSF

Balsalazide

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Balsalazide

hsa04966

Collecting duct acid secretion

4.93E-02

P00918

CA2

Balsalazide

hsa04976

Bile secretion

4.50E-02

Q9BY07

SLC4A5

Balsalazide

hsa05130

Pathogenic Escherichia coli infection

4.91E-04

Q14247, P56750, O00501, P25116

CTTN, CLDN17, CLDN5, F2R

Balsalazide

hsa05133

Pertussis

1.86E-03

P09871, P0C0L4, Q02556

C1S, C4A, IRF8

Balsalazide

hsa05140

Leishmaniasis

4.75E-04

P13612, O75015, P14598, P13765, O60603, P01375, Q16539, P51617, Q15080

ITGA4, FCGR3B, NCF1, HLA-DOB, TLR2, TNF, MAPK14, IRAK1, NCF4

Balsalazide

hsa05143

African trypanosomiasis

1.31E-02

P69905, P68871

HBA2, HBB

Balsalazide

hsa05144

Malaria

3.09E-02

P69905, P68871

HBA2, HBB

Balsalazide

hsa05146

Amoebiasis

3.91E-02

P09341, P27930, P01375, O60603, P05089, P22694, P08311

CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSG

Balsalazide

hsa05150

Staphylococcus aureus infection

1.65E-02

P21730, P21462, O75015, P13765, Q16581, P49913

C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, CAMP

Balsalazide

hsa05152

Tuberculosis

8.54E-03

O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617

FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1

Balsalazide

hsa05200

Pathways in cancer

9.46E-03

Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784

LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Balsalazide

hsa05202

Transcriptional misregulation in cancer

2.61E-04

Q12778, Q15532, Q13315, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522

FOXO1, SS18, ATM, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	Q12778	FOXO1	Forkhead box protein O1	-0.72
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P22894	MMP8	Neutrophil collagenase	Q15532	SS18	Protein SSXT	-0.867
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P22894	MMP8	Neutrophil collagenase	P14780	MMP9	Matrix metalloproteinase-9	0.882
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
P22894	MMP8	Neutrophil collagenase	P14923	JUP	Junction plakoglobin	-0.809
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
P22894	MMP8	Neutrophil collagenase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734