PharmaCoNets of Azithromycin (SPCN: 29.35 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Azithromycinhsa00052Galactose metabolism6.39E-042P06280, O43451GLA, MGAMMore
Azithromycinhsa00500Starch and sucrose metabolism1.75E-032O43451, P06737MGAM, PYGLMore
Azithromycinhsa00730Thiamine metabolism1.50E-042P05186, P24666ALPL, ACP1More
Azithromycinhsa00830Retinol metabolism1.08E-023Q9BPW9, O75911, P11712DHRS9, DHRS3, CYP2C9More
Azithromycinhsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Azithromycinhsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Azithromycinhsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Azithromycinhsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Azithromycinhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Azithromycinhsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Azithromycinhsa04071Sphingolipid signaling pathway1.60E-037P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2More
Azithromycinhsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Azithromycinhsa04140Autophagy - animal3.72E-025P22694, Q14643, P10415, Q9H1Y0, Q04759PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Azithromycinhsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Azithromycinhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Azithromycinhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Azithromycinhsa04217Necroptosis4.42E-046P07900, P15104, P05141, P01584, P0C0S5, Q13557HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2DMore
Azithromycinhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Azithromycinhsa04612Antigen processing and presentation2.84E-027P13765, P48382, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Azithromycinhsa04613Neutrophil extracellular trap formation4.94E-0211O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, P49913, P21730, P21462TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1More
Azithromycinhsa04640Hematopoietic cell lineage1.64E-0312P13612, P14778, P27930, P11215, P15144, P25063, P07766, P09693, P01732, P09564, P13765, P01375ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNFMore
Azithromycinhsa04650Natural killer cell mediated cytotoxicity2.48E-038P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3More
Azithromycinhsa04657IL-17 signaling pathway4.48E-035P07900, P49841, P14780, P01375, P01584HSP90AA1, GSK3B, MMP9, TNF, IL1BMore
Azithromycinhsa04658Th1 and Th2 cell differentiation1.80E-0512Q04759, P07766, P20963, P09693, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Azithromycinhsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Azithromycinhsa04660T cell receptor signaling pathway3.83E-0514P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCKMore
Azithromycinhsa04672Intestinal immune network for IgA production1.66E-023P10747, P13765, P13612CD28, HLA-DOB, ITGA4More
Azithromycinhsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Azithromycinhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Azithromycinhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Azithromycinhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Azithromycinhsa04924Renin secretion3.64E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Azithromycinhsa04927Cortisol synthesis and secretion1.66E-023Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Azithromycinhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Azithromycinhsa04932Non-alcoholic fatty liver disease9.70E-034P18848, P01584, P13073, O15239ATF4, IL1B, COX4I1, NDUFA1More
Azithromycinhsa04940Type I diabetes mellitus3.64E-023P10747, P13765, P01375CD28, HLA-DOB, TNFMore
Azithromycinhsa04970Salivary secretion4.92E-024P07550, P22694, Q14643, P49913ADRB2, PRKACB, ITPR1, CAMPMore
Azithromycinhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Azithromycinhsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Azithromycinhsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Azithromycinhsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Azithromycinhsa05020Prion disease3.37E-037P13591, P01584, P11142, O15239, P13073, P18848, P05141NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5More
Azithromycinhsa05022Pathways of neurodegeneration - multiple diseases3.80E-026O15239, P13073, P18848, P05141, P01584, Q13557NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2DMore
Azithromycinhsa05120Epithelial cell signaling in Helicobacter pylori infection2.40E-046Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Azithromycinhsa05134Legionellosis6.38E-046P01584, P11215, P68104, P11142, P09341, P19875IL1B, ITGAM, EEF1A1, HSPA8, CXCL1, CXCL2More
Azithromycinhsa05144Malaria4.92E-024O60603, P01375, P35443, P26718TLR2, TNF, THBS4, KLRK1More
Azithromycinhsa05146Amoebiasis1.80E-0512P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Azithromycinhsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Azithromycinhsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Azithromycinhsa05202Transcriptional misregulation in cancer3.71E-0211P14780, P27930, Q15744, Q16548, P35226, P05164, P12838, P08246, Q9C0K0, P12980, P24522MMP9, IL1R2, CEBPE, BCL2A1, BMI1, MPO, DEFA4, ELA2, BCL11B, LYL1, GADD45AMore
Azithromycinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Azithromycinhsa05310Asthma1.66E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Azithromycinhsa05321Inflammatory bowel disease1.14E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Azithromycinhsa05323Rheumatoid arthritis1.58E-025P01375, P13765, P10747, P09341, O60603TNF, HLA-DOB, CD28, CXCL1, TLR2More
Azithromycinhsa05332Graft-versus-host disease2.03E-035P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Azithromycinhsa05415Diabetic cardiomyopathy2.87E-024P05141, O15239, P13073, Q13557SLC25A5, NDUFA1, COX4I1, CAMK2DMore

Community members of Azithromycin (SDC: 3.42)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q9UM07PADI4ProteinNonearginine deiminase typeNone4Reported10.14880.27780.42671.0567
P24666ACP1Low molecular weight phosphotyrosine protein phosphatasePredicted00.07040.10480.23610.481
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
PADI4Q9UM07IC50>10000000