PharmaCoNets

PharmaCoNets of Azilsartan-medoxomil (S_PCN: 63.91 )

Azilsartan-medoxomil regulated-network (S_DN: 17.65)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Azilsartan-medoxomil

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Azilsartan-medoxomil

hsa00071

Fatty acid degradation

4.66E-02

O75521, P11766, P33121

ECI2, ADH5, ACSL1

Azilsartan-medoxomil

hsa00190

Oxidative phosphorylation

2.21E-02

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Azilsartan-medoxomil

hsa00220

Arginine biosynthesis

2.86E-02

P15104, P05089

GLUL, ARG1

Azilsartan-medoxomil

hsa00230

Purine metabolism

4.93E-02

P21589

NT5E

Azilsartan-medoxomil

hsa00240

Pyrimidine metabolism

1.81E-02

P21589

NT5E

Azilsartan-medoxomil

hsa00280

Valine, leucine and isoleucine degradation

1.67E-02

P55809, Q9HCC0, Q02252, P11310

OXCT1, MCCC2, ALDH6A1, ACADM

Azilsartan-medoxomil

hsa00500

Starch and sucrose metabolism

3.03E-05

O43451, P46976, P06737

MGAM, GYG1, PYGL

Azilsartan-medoxomil

hsa00561

Glycerolipid metabolism

2.21E-02

O14494, P06280, P23743

PLPP1, GLA, DGKA

Azilsartan-medoxomil

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Azilsartan-medoxomil

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Azilsartan-medoxomil

hsa00591

Linoleic acid metabolism

1.29E-03

P11712

CYP2C9

Azilsartan-medoxomil

hsa00600

Sphingolipid metabolism

3.96E-02

Q9BX95, O14494, P06280

SGPP1, PLPP1, GLA

Azilsartan-medoxomil

hsa00730

Thiamine metabolism

3.03E-03

P05186, P24666

ALPL, ACP1

Azilsartan-medoxomil

hsa00760

Nicotinate and nicotinamide metabolism

9.09E-03

P21589

NT5E

Azilsartan-medoxomil

hsa00770

Pantothenate and CoA biosynthesis

7.90E-03

O95498, O95497, Q9NRN7

VNN2, VNN1, AASDHPPT

Azilsartan-medoxomil

hsa00970

Aminoacyl-tRNA biosynthesis

1.58E-04

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Azilsartan-medoxomil

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Azilsartan-medoxomil

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Azilsartan-medoxomil

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Azilsartan-medoxomil

hsa01210

2-Oxocarboxylic acid metabolism

3.43E-02

P50213

IDH3A

Azilsartan-medoxomil

hsa01524

Platinum drug resistance

1.13E-02

P10415, Q13489, P78417, P23025, P43246

BCL2, BIRC3, GSTO1, XPA, MSH2

Azilsartan-medoxomil

hsa02010

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Azilsartan-medoxomil

hsa03008

Ribosome biogenesis in eukaryotes

2.60E-03

Q9NYH9, P78345, Q9BVP2, O15381, Q9GZY0

UTP6, RPP38, GNL3, NVL, NXF2; NXF2B

Azilsartan-medoxomil

hsa03013

RNA transport

3.55E-05

O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, Q9Y6A5, P51114

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, TACC3, FXR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P21462	FPR1	fMet-Leu-Phe receptor	O14980	XPO1	Exportin-1	-0.742
P22748	CA4	Carbonic anhydrase 4	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.879
P21462	FPR1	fMet-Leu-Phe receptor	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.874
P51684	CCR6	C-C chemokine receptor type 6	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.924
P21462	FPR1	fMet-Leu-Phe receptor	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	-0.78
P22748	CA4	Carbonic anhydrase 4	O14893	GEMIN2	Gem-associated protein 2	-0.709
P21462	FPR1	fMet-Leu-Phe receptor	O14893	GEMIN2	Gem-associated protein 2	-0.87
P51684	CCR6	C-C chemokine receptor type 6	O14893	GEMIN2	Gem-associated protein 2	0.771
P22748	CA4	Carbonic anhydrase 4	P61326	MAGOH	Protein mago nashi homolog	-0.822
P21462	FPR1	fMet-Leu-Phe receptor	P61326	MAGOH	Protein mago nashi homolog	-0.835
P51684	CCR6	C-C chemokine receptor type 6	P61326	MAGOH	Protein mago nashi homolog	0.704
P22748	CA4	Carbonic anhydrase 4	Q7Z3B4	NUP54	Nucleoporin p54	-0.776
P21462	FPR1	fMet-Leu-Phe receptor	Q7Z3B4	NUP54	Nucleoporin p54	-0.903
P51684	CCR6	C-C chemokine receptor type 6	Q7Z3B4	NUP54	Nucleoporin p54	0.811
P22748	CA4	Carbonic anhydrase 4	P35658	NUP214	Nuclear pore complex protein Nup214	0.827
P21462	FPR1	fMet-Leu-Phe receptor	P35658	NUP214	Nuclear pore complex protein Nup214	0.971
P22748	CA4	Carbonic anhydrase 4	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.786
P21462	FPR1	fMet-Leu-Phe receptor	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.89
P51684	CCR6	C-C chemokine receptor type 6	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.701
P22748	CA4	Carbonic anhydrase 4	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.869
P21462	FPR1	fMet-Leu-Phe receptor	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.953
P51684	CCR6	C-C chemokine receptor type 6	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.711
P22748	CA4	Carbonic anhydrase 4	P78345	RPP38	Ribonuclease P protein subunit p38	-0.731
P51684	CCR6	C-C chemokine receptor type 6	P78345	RPP38	Ribonuclease P protein subunit p38	0.861
P21462	FPR1	fMet-Leu-Phe receptor	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	-0.721
P22748	CA4	Carbonic anhydrase 4	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.912
P21462	FPR1	fMet-Leu-Phe receptor	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.904
P51684	CCR6	C-C chemokine receptor type 6	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.732
P21462	FPR1	fMet-Leu-Phe receptor	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	-0.713

Azilsartan-medoxomil

hsa03020

RNA polymerase

4.40E-02

P24928, P62487

POLR2A, POLR2G

Azilsartan-medoxomil

hsa03040

Spliceosome

5.79E-03

Q14562, O43143, O60508, Q99633, Q13595, Q01130, Q9UMS4

DHX8, DHX15, CDC40, PRPF18, TRA2A, SFRS2, PRPF19

Azilsartan-medoxomil

hsa03460

Fanconi anemia pathway

2.71E-02

O94782

USP1

Azilsartan-medoxomil

hsa04015

Rap1 signaling pathway

1.58E-02

P20827, P49767, P63261, P25116, P0DP23, P17252

EFNA1, VEGFC, ACTG1, F2R, CALM1, PRKCA

Azilsartan-medoxomil

hsa04020

Calcium signaling pathway

1.16E-03

Q16566, P17252, O15399, P25116, P0DP23, P23634, P49767

CAMK4, PRKCA, GRIN2D, F2R, CALM1, ATP2B4, VEGFC

Azilsartan-medoxomil

hsa04022

cGMP-PKG signaling pathway

2.55E-02

P18848, Q8WYR1, P05141, P0DP24

ATF4, PIK3R5, SLC25A5, CALM2

Azilsartan-medoxomil

hsa04024

cAMP signaling pathway

2.84E-02

P0DP23, P23634, Q16566, O15399, P25116

CALM1, ATP2B4, CAMK4, GRIN2D, F2R

Azilsartan-medoxomil

hsa04060

Cytokine-cytokine receptor interaction

9.80E-04

P27930, P14778, P26842, Q9UHF4, Q13651, P16871, P25024, Q9UBD3, P47992, P02775, P09341, P32248, P51684, P18510, P09603, P01730

IL1R2, IL1R1, CD27, IL20RA, IL10RA, IL7R, CXCR1, XCL2, XCL1, PPBP, CXCL1, CCR7, CCR6, IL1RN, CSF1, CD4

Azilsartan-medoxomil

hsa04061

Viral protein interaction with cytokine and cytokine receptor

7.74E-04

P51684, P32248, P02775, P47992, Q9UBD3, Q9UHF4

CCR6, CCR7, PPBP, XCL1, XCL2, IL20RA

Azilsartan-medoxomil

hsa04062

Chemokine signaling pathway

3.93E-03

P25024, P25025, P47992, Q9UBD3, P07948, P63218, P50151, P49407, Q08881, P49841

CXCR1, CXCR2, XCL1, XCL2, LYN, GNG5, GNG10, ARRB1, ITK, GSK3B

Azilsartan-medoxomil

hsa04064

NF-kappa B signaling pathway

4.17E-03

P10415, P51617, O00463, Q13546, P14778, Q9UDY8, Q13077, Q16548, Q8WV28, P24522, P09341

BCL2, IRAK1, TRAF5, RIPK1, IL1R1, MALT1, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1

Azilsartan-medoxomil

hsa04066

HIF-1 signaling pathway

3.40E-02

Q09472, P07195, P10415

EP300, LDHB, BCL2

Azilsartan-medoxomil

hsa04068

FoxO signaling pathway

3.52E-02

Q96BR1

SGK3

Azilsartan-medoxomil

hsa04070

Phosphatidylinositol signaling system

4.07E-02

P0DP23, Q14643, O14732, P17252

CALM1, ITPR1, IMPA2, PRKCA

Azilsartan-medoxomil

hsa04071

Sphingolipid signaling pathway

1.07E-04

P17252, Q9H228, P01375, Q13362, Q16537, Q9BX95, Q16539, P04637, P10415

PRKCA, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, MAPK14, TP53, BCL2

Azilsartan-medoxomil

hsa04110

Cell cycle

2.06E-02

Q9UJX4, O60566, Q09472, P24522, P04637, P49918

ANAPC5, BUB1B, EP300, GADD45A, TP53, CDKN1C

Azilsartan-medoxomil

hsa04141

Protein processing in endoplasmic reticulum

2.78E-02

P07384, O95487, O95816

CAPN1, SEC24B, BAG2

Azilsartan-medoxomil

hsa04145

Phagosome

2.30E-03

P60709, P63261, Q15075, Q15080, P14598, Q13509, P68371, Q13488, P27824

ACTB, ACTG1, EEA1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, CANX

Azilsartan-medoxomil

hsa04146

Peroxisome

2.42E-02

O43933, P56589, Q9UKG9, O75521, P33121

PEX1, PEX3, CROT, ECI2, ACSL1

Azilsartan-medoxomil

hsa04151

PI3K-Akt signaling pathway

7.39E-03

P62753, O43521, P27348, Q8WYR1, P18848, O00141, Q6ZUJ8

RPS6, BCL2L11, YWHAQ, PIK3R5, ATF4, SGK, PIK3AP1

Azilsartan-medoxomil

hsa04210

Apoptosis

2.44E-04

P04637, P10415, O75460, P24522, Q13077, O43521, P43234, Q9UBR2, P18848, Q14643

TP53, BCL2, ERN1, GADD45A, TRAF1, BCL2L11, CTSO, CTSZ, ATF4, ITPR1

Azilsartan-medoxomil

hsa04217

Necroptosis

5.66E-03

P15104, P05141, P01584, P0C0S5, Q9H444

GLUL, SLC25A5, IL1B, H2AFZ, CHMP4B

Azilsartan-medoxomil

hsa04261

Adrenergic signaling in cardiomyocytes

3.44E-02

Q16537, P0DP23, P17252, P10415, P20020

PPP2R5E, CALM1, PRKCA, BCL2, ATP2B1

Azilsartan-medoxomil

hsa04270

Vascular smooth muscle contraction

2.89E-02

P35579, P35318

MYH9, ADM

Azilsartan-medoxomil

hsa04350

TGF-beta signaling pathway

4.88E-02

P37173

TGFBR2

Azilsartan-medoxomil

hsa04360

Axon guidance

1.50E-02

P20827, P23528, Q06124

EFNA1, CFL1, PTPN11

Azilsartan-medoxomil

hsa04390

Hippo signaling pathway

1.47E-02

P63261, Q13485, Q9UJU2, O43623, Q13489

ACTG1, SMAD4, LEF1, SNAI2, BIRC3

Azilsartan-medoxomil

hsa04510

Focal adhesion

3.21E-02

Q15942, P17252, Q13489, P10415, P49767, P63261

ZYX, PRKCA, BIRC3, BCL2, VEGFC, ACTG1

Azilsartan-medoxomil

hsa04520

Adherens junction

3.36E-02

Q13485, Q9UJU2, O43623, P63261

SMAD4, LEF1, SNAI2, ACTG1

Azilsartan-medoxomil

hsa04530

Tight junction

1.74E-03

P63261, P16989, P56750, Q9Y478, Q92974, Q14247

ACTG1, CSDA, CLDN17, PRKAB1, ARHGEF2, CTTN

Azilsartan-medoxomil

hsa04540

Gap junction

4.76E-02

P17252, Q13509, P68371

PRKCA, TUBB3, TUBB2C

Azilsartan-medoxomil

hsa04610

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

Azilsartan-medoxomil

hsa04612

Antigen processing and presentation

2.10E-03

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Azilsartan-medoxomil

hsa04613

Neutrophil extracellular trap formation

5.73E-06

P17252, P11215, O60603, P05164, P08246, Q9UM07, Q92769, Q6FI13, Q93077, P62807, P33778, O60814, P68431, P14598, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539

PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC2, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC3, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51684	CCR6	C-C chemokine receptor type 6	P17252	PRKCA	Protein kinase C alpha type	0.738
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P22748	CA4	Carbonic anhydrase 4	O60603	TLR2	Toll-like receptor 2	0.919
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
P51684	CCR6	C-C chemokine receptor type 6	P08246	ELA2	Neutrophil elastase	-0.706
P22748	CA4	Carbonic anhydrase 4	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.856
P51684	CCR6	C-C chemokine receptor type 6	Q92769	HDAC2	Histone deacetylase 2	0.702
P22748	CA4	Carbonic anhydrase 4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.866
P51684	CCR6	C-C chemokine receptor type 6	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.86
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51684	CCR6	C-C chemokine receptor type 6	P33778	H2BC3	Histone H2B type 1-B	0.704
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P51684	CCR6	C-C chemokine receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	-0.713
P22748	CA4	Carbonic anhydrase 4	Q15080	NCF4	Neutrophil cytosol factor 4	0.951
P51684	CCR6	C-C chemokine receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	-0.803
P22748	CA4	Carbonic anhydrase 4	P20160	AZU1	Azurocidin	0.747
P22748	CA4	Carbonic anhydrase 4	P08311	CTSG	Cathepsin G	0.717
P22748	CA4	Carbonic anhydrase 4	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
P22748	CA4	Carbonic anhydrase 4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.826
P22748	CA4	Carbonic anhydrase 4	P21462	FPR1	fMet-Leu-Phe receptor	0.895
P51684	CCR6	C-C chemokine receptor type 6	P21462	FPR1	fMet-Leu-Phe receptor	-0.7
P22748	CA4	Carbonic anhydrase 4	O43315	AQP9	Aquaporin-9	0.771
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767

Azilsartan-medoxomil

hsa04614

Renin-angiotensin system

1.52E-02

P50052

AGTR2

Azilsartan-medoxomil

hsa04621

NOD-like receptor signaling pathway

2.27E-02

Q9H1Y0, P43490, O00463, Q05823, P01375, P49913, P59665, P59666, P12838

ATG5, PBEF1, TRAF5, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4

Azilsartan-medoxomil

hsa04640

Hematopoietic cell lineage

7.16E-03

P13612, P14778, P27930, P07766, P01730, P09564, P09603

ITGA4, IL1R1, IL1R2, CD3E, CD4, CD7, CSF1

Azilsartan-medoxomil

hsa04650

Natural killer cell mediated cytotoxicity

3.20E-06

P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715

TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721

Azilsartan-medoxomil

hsa04657

IL-17 signaling pathway

6.10E-03

O00463, Q16539, P49841, P09341, P14780, Q9UJX4, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, LCN2, TNF

Azilsartan-medoxomil

hsa04658

Th1 and Th2 cell differentiation

4.54E-03

P07766, P20963, P01730, P06239, Q9UL17, Q13761

CD3E, CD247, CD4, LCK, TBX21, RUNX3

Azilsartan-medoxomil

hsa04659

Th17 cell differentiation

1.43E-02

P01730, P06239, P14778, Q9UL17, P07766, P20963

CD4, LCK, IL1R1, TBX21, CD3E, CD247

Azilsartan-medoxomil

hsa04660

T cell receptor signaling pathway

1.49E-03

P01375, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Azilsartan-medoxomil

hsa04664

Fc epsilon RI signaling pathway

7.22E-03

Q9UQC2, P20292

GAB2, ALOX5AP

Azilsartan-medoxomil

hsa04666

Fc gamma R-mediated phagocytosis

2.22E-02

P49006, P06396, P14598, P17252

MARCKSL1, GSN, NCF1, PRKCA

Azilsartan-medoxomil

hsa04668

TNF signaling pathway

2.91E-02

P18848, P01584, P20333

ATF4, IL1B, TNFRSF1B

Azilsartan-medoxomil

hsa04714

Thermogenesis

1.25E-02

P15336, P63261, Q9Y478

ATF2, ACTG1, PRKAB1

Azilsartan-medoxomil

hsa04720

Long-term potentiation

3.70E-04

P17252, Q16566, P0DP23, O15399, Q14643

PRKCA, CAMK4, CALM1, GRIN2D, ITPR1

Azilsartan-medoxomil

hsa04724

Glutamatergic synapse

2.72E-03

P48058, P43003, P63218, P50151, P15104

GRIA4, SLC1A3, GNG5, GNG10, GLUL

Azilsartan-medoxomil

hsa04727

GABAergic synapse

3.89E-02

P63218, P50151, P15104

GNG5, GNG10, GLUL

Azilsartan-medoxomil

hsa04728

Dopaminergic synapse

2.82E-02

P14416, P63218, P50151, P49841, Q16539, P49407

DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1

Azilsartan-medoxomil

hsa04912

GnRH signaling pathway

4.42E-02

P17252, Q14643, P0DP23

PRKCA, ITPR1, CALM1

Azilsartan-medoxomil

hsa04916

Melanogenesis

3.55E-02

P0DP23, Q9UJU2, P17252

CALM1, LEF1, PRKCA

Azilsartan-medoxomil

hsa04920

Adipocytokine signaling pathway

2.80E-02

Q06124, Q9Y478

PTPN11, PRKAB1

Azilsartan-medoxomil

hsa04921

Oxytocin signaling pathway

4.19E-02

P0DP23, P17252, Q16566, P63261

CALM1, PRKCA, CAMK4, ACTG1

Azilsartan-medoxomil

hsa04925

Aldosterone synthesis and secretion

2.90E-04

Q14643, P0DP23, P17252, Q16566, P20020, P23634

ITPR1, CALM1, PRKCA, CAMK4, ATP2B1, ATP2B4

Azilsartan-medoxomil

hsa04932

Non-alcoholic fatty liver disease

2.05E-03

O43521, P18848, O75460, P01584, P13073

BCL2L11, ATF4, ERN1, IL1B, COX4I1

Azilsartan-medoxomil

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.36E-02

Q13485, P10415, P49767, P17252

SMAD4, BCL2, VEGFC, PRKCA

Azilsartan-medoxomil

hsa04962

Vasopressin-regulated water reabsorption

7.22E-03

P52566, P62491

ARHGDIB, RAB11A

Azilsartan-medoxomil

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Azilsartan-medoxomil

hsa04966

Collecting duct acid secretion

2.32E-03

P02730, P00918, Q9Y666

SLC4A1, CA2, SLC12A7

Azilsartan-medoxomil

hsa04970

Salivary secretion

8.71E-04

Q14643, P20020, P23634, P17252, P0DP23

ITPR1, ATP2B1, ATP2B4, PRKCA, CALM1

Azilsartan-medoxomil

hsa04971

Gastric acid secretion

4.76E-02

P17252, P63261, P0DP23

PRKCA, ACTG1, CALM1

Azilsartan-medoxomil

hsa04972

Pancreatic secretion

1.00E-02

Q14643, P20020, P17252

ITPR1, ATP2B1, PRKCA

Azilsartan-medoxomil

hsa04978

Mineral absorption

3.94E-02

P23634, Q9BXS9

ATP2B4, SLC26A6

Azilsartan-medoxomil

hsa05010

Alzheimer disease

2.78E-02

P13073, O75460, P0DP24, P01584, P18848, P05141

COX4I1, ERN1, CALM2, IL1B, ATF4, SLC25A5

Azilsartan-medoxomil

hsa05012

Parkinson disease

3.89E-02

P13073, P05141, O75460, P18848, P0DP24

COX4I1, SLC25A5, ERN1, ATF4, CALM2

Azilsartan-medoxomil

hsa05014

Amyotrophic lateral sclerosis

4.31E-02

O15399, P10415, Q13509, P68371, Q53GS7, P63261, Q9GZY0

GRIN2D, BCL2, TUBB3, TUBB2C, GLE1, ACTG1, NXF2; NXF2B

Azilsartan-medoxomil

hsa05016

Huntington disease

4.87E-02

P13073, P24928, P62487, P05141, O75460

COX4I1, POLR2A, POLR2G, SLC25A5, ERN1

Azilsartan-medoxomil

hsa05022

Pathways of neurodegeneration - multiple diseases

1.98E-02

P13073, O75460, P18848, P05141, P20333, P01584, P0DP24

COX4I1, ERN1, ATF4, SLC25A5, TNFRSF1B, IL1B, CALM2

Azilsartan-medoxomil

hsa05031

Amphetamine addiction

1.49E-02

O15399, P0DP23, Q16566, P17252

GRIN2D, CALM1, CAMK4, PRKCA

Azilsartan-medoxomil

hsa05034

Alcoholism

3.11E-05

Q96RR4, Q93077, P62807, O60814, P84243, P68431

CAMKK2, HIST1H2AC, HIST1H2BC, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Azilsartan-medoxomil

hsa05110

Vibrio cholerae infection

4.50E-03

Q13488, P17252, P19174, P60709

TCIRG1, PRKCA, PLCG1, ACTB

Azilsartan-medoxomil

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

1.85E-03

Q16539, P09341, P25024, P25025, P07948

MAPK14, CXCL1, CXCR1, CXCR2, LYN

Azilsartan-medoxomil

hsa05130

Pathogenic Escherichia coli infection

9.80E-03

Q92974, P63261, Q06124, O95487

ARHGEF2, ACTG1, PTPN11, SEC24B

Azilsartan-medoxomil

hsa05132

Salmonella infection

2.12E-04

P51617, Q9UJU2, P63261, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509, P68371

IRAK1, LEF1, ACTG1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3, TUBB2C

Azilsartan-medoxomil

hsa05133

Pertussis

3.10E-03

P0DP23, P23528, P09871, P0C0L4

CALM1, CFL1, C1S, C4A

Azilsartan-medoxomil

hsa05135

Yersinia infection

4.65E-02

P13612, P06239, Q16539, P01375, P49841

ITGA4, LCK, MAPK14, TNF, GSK3B

Azilsartan-medoxomil

hsa05140

Leishmaniasis

1.74E-04

O75015, P14598, P42224, P13765, O60603, P25963, P29350, P49006, Q16539, P51617, Q15080

FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4

Azilsartan-medoxomil

hsa05143

African trypanosomiasis

1.31E-02

P69905, P68871

HBA2, HBB

Azilsartan-medoxomil

hsa05144

Malaria

2.01E-05

P60033, P69905, P68871, O60603, P01375, P35443, P26718

CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1

Azilsartan-medoxomil

hsa05146

Amoebiasis

7.13E-04

Q13751, P09341, P14778, P27930, O60603, P05089, P12814

LAMB3, CXCL1, IL1R1, IL1R2, TLR2, ARG1, ACTN1

Azilsartan-medoxomil

hsa05150

Staphylococcus aureus infection

1.02E-03

P21730, P21462, O75015, P59665, P59666, P12838, P49913

C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Azilsartan-medoxomil

hsa05163

Human cytomegalovirus infection

1.87E-03

P01375, P63218, P50151, Q14643, P49841, P14778, P25025, Q16539, P04637, O00463

TNF, GNG5, GNG10, ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5

Azilsartan-medoxomil

hsa05168

Herpes simplex virus 1 infection

1.94E-02

Q9UKJ0, P01568, Q9GZY0, Q01130, Q13489, Q13398, Q03923, Q9UDV6, P10415

PILRB, IFNA21, NXF2; NXF2B, SFRS2, BIRC3, ZNF211, ZNF85, ZNF212, BCL2

Azilsartan-medoxomil

hsa05169

Epstein-Barr virus infection

2.15E-03

P13765, Q92769, P04637, Q13546, P10415, P24522, O60603, P29728, P51617, P09693

HLA-DOB, HDAC2, TP53, RIPK1, BCL2, GADD45A, TLR2, OAS2, IRAK1, CD3G

Azilsartan-medoxomil

hsa05170

Human immunodeficiency virus 1 infection

6.54E-03

P0DP23, P17252, Q13546, Q14643, P51617, O60603, P09693, P10415, Q9Y6Q5

CALM1, PRKCA, RIPK1, ITPR1, IRAK1, TLR2, CD3G, BCL2, AP1M2

Azilsartan-medoxomil

hsa05200

Pathways in cancer

2.37E-03

P04637, Q9UJU2, P17252, Q09472, P43246, Q13485, P14923, P10415, Q13489, Q13077, P49767, P25116, O95267, P78417, P24522, P0DP23, P01568, P16871

TP53, LEF1, PRKCA, EP300, MSH2, SMAD4, JUP, BCL2, BIRC3, TRAF1, VEGFC, F2R, RASGRP1, GSTO1, GADD45A, CALM1, IFNA21, IL7R

Azilsartan-medoxomil

hsa05202

Transcriptional misregulation in cancer

1.16E-03

Q15532, P41732, P14780, P27930, P14923, Q16548, Q13077, O15550, P04637, P35226, P05164, P08246, Q9C0K0, P24522

SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, TRAF1, UTX, TP53, BMI1, MPO, ELA2, BCL11B, GADD45A

Azilsartan-medoxomil

hsa05203

Viral carcinogenesis

2.93E-03

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Azilsartan-medoxomil

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Azilsartan-medoxomil

hsa05210

Colorectal cancer

2.41E-02

P10415, P04637, Q9UJU2, P24522

BCL2, TP53, LEF1, GADD45A

Azilsartan-medoxomil

hsa05211

Renal cell carcinoma

1.06E-02

Q06124, Q99814

PTPN11, EPAS1

Azilsartan-medoxomil

hsa05212

Pancreatic cancer

3.40E-02

P37173

TGFBR2

Azilsartan-medoxomil

hsa05213

Endometrial cancer

1.91E-02

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Azilsartan-medoxomil

hsa05214

Glioma

8.71E-04

P0DP23, Q16566, P17252, P04637, P24522

CALM1, CAMK4, PRKCA, TP53, GADD45A

Azilsartan-medoxomil

hsa05215

Prostate cancer

1.94E-02

P10415, Q9UJU2, Q09472, P04637

BCL2, LEF1, EP300, TP53

Azilsartan-medoxomil

hsa05216

Thyroid cancer

2.42E-04

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Azilsartan-medoxomil

hsa05217

Basal cell carcinoma

1.56E-03

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Azilsartan-medoxomil

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Azilsartan-medoxomil

hsa05222

Small cell lung cancer

1.94E-02

P10415, Q13077, P04637, P24522

BCL2, TRAF1, TP53, GADD45A

Azilsartan-medoxomil

hsa05223

Non-small cell lung cancer

3.99E-02

P17252, O43524, P19174, O75293

PRKCA, FOXO3, PLCG1, GADD45B

Azilsartan-medoxomil

hsa05224

Breast cancer

5.34E-03

Q9UJU2, P49841, Q92837, P04637, P24522

LEF1, GSK3B, FRAT1, TP53, GADD45A

Azilsartan-medoxomil

hsa05226

Gastric cancer

8.86E-03

Q9UJU2, P04637, P24522, P14923, P10415

LEF1, TP53, GADD45A, JUP, BCL2

Azilsartan-medoxomil

hsa05230

Central carbon metabolism in cancer

4.04E-02

P07195, P04637

LDHB, TP53

Azilsartan-medoxomil

hsa05231

Choline metabolism in cancer

3.99E-02

P19174, P23743, O14494, P17252

PLCG1, DGKA, PLPP1, PRKCA

Azilsartan-medoxomil

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

4.55E-02

O95267, P09693, O60603, Q16539, P01730

RASGRP1, CD3G, TLR2, MAPK14, CD4

Azilsartan-medoxomil

hsa05322

Systemic lupus erythematosus

1.49E-05

P09871, Q93077, P62807, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Azilsartan-medoxomil

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Azilsartan-medoxomil

hsa05415

Diabetic cardiomyopathy

3.94E-02

P17252, P14598, Q15080, Q16718, O14521, P04406

PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDH

Azilsartan-medoxomil

hsa05418

Fluid shear stress and atherosclerosis

2.06E-04

Q16539, P78417, P10599, P14780, P01375, P63261, P04637, P10415, P14778, P27930, P0DP23, Q92974

MAPK14, GSTO1, TXN, MMP9, TNF, ACTG1, TP53, BCL2, IL1R1, IL1R2, CALM1, ARHGEF2

UniProtAC	Gene Name	Protein Name	Reported/ Predicted	DisGeNET	S_PV	S_drugability	S_HiSBiN	S_DisG

PharmaCoNets of Azilsartan-medoxomil (SPCN: 63.91 )

Azilsartan-medoxomil regulated-network (SDN: 17.65)

Community members of Azilsartan-medoxomil (SDC: 3.62)

PharmaCoNets of Azilsartan-medoxomil (S_PCN: 63.91 )

Azilsartan-medoxomil regulated-network (S_DN: 17.65)

Community members of Azilsartan-medoxomil (S_DC: 3.62)