PharmaCoNets of Azelastine (SPCN: 272.14 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Azelastinehsa00030Pentose phosphate pathway1.08E-053P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Azelastinehsa00052Galactose metabolism1.06E-032P06280, O43451GLA, MGAMMore
Azelastinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Azelastinehsa00130Ubiquinone and other terpenoid-quinone biosynthesis1.66E-021Q9BQB6VKORC1More
Azelastinehsa00190Oxidative phosphorylation5.61E-053Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Azelastinehsa00220Arginine biosynthesis3.02E-053P15104, P05089, P49448GLUL, ARG1, GLUD2More
Azelastinehsa00230Purine metabolism6.91E-043P20839, Q16774, Q02153IMPDH1, GUK1, GUCY1B3More
Azelastinehsa00240Pyrimidine metabolism2.20E-023P21589, P32320, P04183NT5E, CDA, TK1More
Azelastinehsa00250Alanine, aspartate and glutamate metabolism7.74E-042Q96RQ9, P15104IL4I1, GLULMore
Azelastinehsa00260Glycine, serine and threonine metabolism1.99E-021P22557ALAS2More
Azelastinehsa00270Cysteine and methionine metabolism3.39E-022Q96RQ9, P40926IL4I1, MDH2More
Azelastinehsa00350Tyrosine metabolism3.40E-021P28332ADH6More
Azelastinehsa00500Starch and sucrose metabolism4.34E-073O43451, P46976, P06737MGAM, GYG1, PYGLMore
Azelastinehsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Azelastinehsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Azelastinehsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Azelastinehsa00561Glycerolipid metabolism4.97E-045Q8NEB5, P51648, P14550, P23743, Q86XP1PPAPDC1B, ALDH3A2, AKR1A1, DGKA, DGKHMore
Azelastinehsa00562Inositol phosphate metabolism7.30E-044P27987, Q96PE3, P19174, P42338ITPKB, INPP4A, PLCG1, PIK3CBMore
Azelastinehsa00565Ether lipid metabolism3.00E-031Q8N661TMEM86BMore
Azelastinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Azelastinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Azelastinehsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Azelastinehsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Azelastinehsa00620Pyruvate metabolism2.51E-022P40925, P51648MDH1, ALDH3A2More
Azelastinehsa00630Glyoxylate and dicarboxylate metabolism1.54E-052P40925, P15104MDH1, GLULMore
Azelastinehsa00670One carbon pool by folate1.33E-022P04818, Q99707TYMS, MTRMore
Azelastinehsa00730Thiamine metabolism2.43E-062P05186, P24666ALPL, ACP1More
Azelastinehsa00770Pantothenate and CoA biosynthesis2.26E-043O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Azelastinehsa00790Folate biosynthesis4.74E-022P07101, P42330TH, AKR1C3More
Azelastinehsa00830Retinol metabolism3.93E-023P00352, Q9BPW9, O75911ALDH1A1, DHRS9, DHRS3More
Azelastinehsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Azelastinehsa00900Terpenoid backbone biosynthesis2.72E-043Q01581, P49354, Q9UHG3HMGCS1, FNTA, PCYOX1More
Azelastinehsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Azelastinehsa00970Aminoacyl-tRNA biosynthesis8.42E-074O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Azelastinehsa00980Metabolism of xenobiotics by cytochrome P4508.40E-043P78417, P28332, P11712GSTO1, ADH6, CYP2C9More
Azelastinehsa00982Drug metabolism - cytochrome P4508.40E-043P11712, P78417, P28332CYP2C9, GSTO1, ADH6More
Azelastinehsa00983Drug metabolism - other enzymes6.64E-053P04183, P32320, P05164TK1, CDA, MPOMore
Azelastinehsa01100Metabolic pathways6.88E-0335Q9NR34, P05089, P15104, P51648, P42338, Q96PE3, P19174, P27987, P32320, Q13370, P22748, P40925, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, P23743, Q9HCC0, P33121, P43034, P09917, P57054, Q9UNP4, Q9BX95, Q53FZ2, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, GLUL, ALDH3A2, PIK3CB, INPP4A, PLCG1, ITPKB, CDA, PDE3B, CA4, MDH1, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, DGKA, MCCC2, ACSL1, PAFAH1B1, ALOX5, PIGP, ST3GAL5, SGPP1, ACSM3, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Azelastinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Azelastinehsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Azelastinehsa01230Biosynthesis of amino acids1.42E-045P51854, P60891, Q99707, P15104, P37837TKTL1, PRPS1, MTR, GLUL, TALDO1More
Azelastinehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Azelastinehsa01521EGFR tyrosine kinase inhibitor resistance3.48E-067P49841, Q92529, P19174, P42338, P04049, P08069, Q9NRA1GSK3B, SHC3, PLCG1, PIK3CB, RAF1, IGF1R, PDGFCMore
Azelastinehsa01522Endocrine resistance4.22E-035P22694, P04049, P08069, P10415, Q13323PRKACB, RAF1, IGF1R, BCL2, BIKMore
Azelastinehsa01523Antifolate resistance1.43E-032Q92820, P04818GGH, TYMSMore
Azelastinehsa01524Platinum drug resistance1.47E-033O15392, P11388, P31751BIRC5, TOP2A, AKT2More
Azelastinehsa02010ABC transporters1.11E-053P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Azelastinehsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Azelastinehsa03013RNA transport2.17E-0822P62826, O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q7Z3B4, P35658, P63279, P68104, Q14152, P55884, O15371, O75822, P78345, P20042, Q14240, P23588, Q9Y6A5, Q14232RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, EIF2S2, EIF4A2, EIF4B, TACC3, EIF2B1More
Azelastinehsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Azelastinehsa03020RNA polymerase7.98E-064P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Azelastinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Azelastinehsa03040Spliceosome5.04E-0817Q14562, O43143, O60508, P08579, Q15427, P26368, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, SF3B4, U2AF2, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Azelastinehsa03050Proteasome4.83E-021P55036PSMD4More
Azelastinehsa03060Protein export1.20E-032P37108, Q15005SRP14, SPCS2More
Azelastinehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Azelastinehsa03430Mismatch repair4.38E-021P20585MSH3More
Azelastinehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Azelastinehsa04010MAPK signaling pathway1.69E-032P04049, P08069RAF1, IGF1RMore
Azelastinehsa04012ErbB signaling pathway2.70E-0710P21860, P49841, P16333, Q92529, Q13557, P19174, O14944, P42338, P01106, P04049ERBB3, GSK3B, NCK1, SHC3, CAMK2D, PLCG1, EREG, PIK3CB, MYC, RAF1More
Azelastinehsa04014Ras signaling pathway1.37E-0614P04049, P31751, P42338, Q92529, P20827, Q9NRA1, P49767, P08069, Q13009, Q7LDG7, P0DP23, P63218, P50151, P19174RAF1, AKT2, PIK3CB, SHC3, EFNA1, PDGFC, VEGFC, IGF1R, TIAM1, RASGRP2, CALM1, GNG5, GNG10, PLCG1More
Azelastinehsa04015Rap1 signaling pathway2.50E-0615P04049, P20827, Q9NRA1, P49767, P08069, P06213, Q96FS4, P11215, Q13009, O00522, Q7LDG7, P42338, P31751, P0DP23, P19174RAF1, EFNA1, PDGFC, VEGFC, IGF1R, INSR, SIPA1, ITGAM, TIAM1, KRIT1, RASGRP2, PIK3CB, AKT2, CALM1, PLCG1More
Azelastinehsa04020Calcium signaling pathway9.63E-0715P27987, Q96DU7, Q08828, P45880, Q13557, P21860, P19174, P0DP23, P05141, P51828, P26678, P63092, P23634, Q9NRA1, P49767ITPKB, ITPKC, ADCY1, VDAC2, CAMK2D, ERBB3, PLCG1, CALM1, SLC25A5, ADCY7, PLN, GNAS, ATP2B4, PDGFC, VEGFCMore
Azelastinehsa04022cGMP-PKG signaling pathway1.31E-0612P04049, Q99941, P18848, P23634, Q8WYR1, P31751, Q08828, P51828, P05141, P45880, P0DP24, P0DP23RAF1, CREBL1, ATF4, ATP2B4, PIK3R5, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2, CALM1More
Azelastinehsa04024cAMP signaling pathway5.33E-045Q08828, P51828, P31751, P0DP23, P04049ADCY1, ADCY7, AKT2, CALM1, RAF1More
Azelastinehsa04060Cytokine-cytokine receptor interaction9.39E-0621P14784, P27930, P14778, P08476, P26842, Q06643, Q13651, P48551, P25024, P25025, Q9UBD3, P47992, P02775, O75509, P01375, P09341, P32248, P51684, P18510, P01730, Q93038IL2RB, IL1R2, IL1R1, INHBA, CD27, LTB, IL10RA, IFNAR2, CXCR1, CXCR2, XCL2, XCL1, PPBP, TNFRSF21, TNF, CXCL1, CCR7, CCR6, IL1RN, CD4, TNFRSF25More
Azelastinehsa04061Viral protein interaction with cytokine and cytokine receptor1.09E-0914Q8NHW4, P51684, P32248, P09341, P19875, P25024, P02775, P25025, P47992, Q9UBD3, Q13651, P14784, P09603, P01375CCL4L2, CCR6, CCR7, CXCL1, CXCL2, CXCR1, PPBP, CXCR2, XCL1, XCL2, IL10RA, IL2RB, CSF1, TNFMore
Azelastinehsa04062Chemokine signaling pathway4.77E-1122P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, Q92529, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P22694, P04049, P49841, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, SHC3, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, PRKACB, RAF1, GSK3B, PIK3R5More
Azelastinehsa04064NF-kappa B signaling pathway3.13E-1324P10415, Q13489, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7BCL2, BIRC3, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLDMore
Azelastinehsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Azelastinehsa04068FoxO signaling pathway3.80E-042P04049, P08069RAF1, IGF1RMore
Azelastinehsa04070Phosphatidylinositol signaling system1.02E-0711P19174, P0DP23, P42338, O14986, P23743, Q86XP1, Q16760, Q96PE3, P48426, P27987, Q96DU7PLCG1, CALM1, PIK3CB, PIP5K1B, DGKA, DGKH, DGKD, INPP4A, PIP4K2A, ITPKB, ITPKCMore
Azelastinehsa04071Sphingolipid signaling pathway4.85E-069P04049, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2RAF1, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Azelastinehsa04072Phospholipase D signaling pathway2.01E-0817P04049, P31751, P42338, Q92529, Q9UQC2, P43657, P25024, P25025, P19174, O14986, Q14344, Q15438, Q08828, P51828, P23743, Q16760, Q9NRA1RAF1, AKT2, PIK3CB, SHC3, GAB2, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, GNA13, PSCD1, ADCY1, ADCY7, DGKA, DGKD, PDGFCMore
Azelastinehsa04080Neuroactive ligand-receptor interaction1.60E-0712P08311, P28472, Q15722, P21453, Q9H228, O00398, Q01726, P41968, P21462, P21730, P14416, P07550CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, MC1R, MC3R, FPR1, C5AR1, DRD2, ADRB2More
Azelastinehsa04110Cell cycle2.12E-069Q9UBD5, P06493, O60566, Q14683, O75293, P30304, P33981, P42773, P01106ORC3, CDK1, BUB1B, SMC1A, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Azelastinehsa04114Oocyte meiosis1.78E-0410P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1RMore
Azelastinehsa04120Ubiquitin mediated proteolysis2.51E-036Q14145, Q13042, P62837, Q15751, O95071, P0CG47KEAP1, CDC16, UBE2D2, HERC1, UBR5, UBBMore
Azelastinehsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Azelastinehsa04137Mitophagy - animal9.52E-032Q07817, P0CG47BCL2L1, UBBMore
Azelastinehsa04140Autophagy - animal7.25E-0714P08069, Q9Y4H2, P31751, P04049, Q7L523, Q9NQL2, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9IGF1R, IRS2, AKT2, RAF1, RRAGA, RRAGD, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Azelastinehsa04141Protein processing in endoplasmic reticulum3.91E-039P30101, P60604, Q99941, O75460, P11142, Q9H3Z4, P07900, P08238, Q9UNL2PDIA3, UBE2G2, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SSR3More
Azelastinehsa04142Lysosome2.45E-039Q99437, P25774, P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916ATP6V0B, CTSS, HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Azelastinehsa04144Endocytosis2.99E-0411P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, P01889, P10321, P49418, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, HLA-B, HLA-C, AMPH, SNX12More
Azelastinehsa04145Phagosome1.35E-0615O75015, Q15080, P14598, Q13509, P68371, Q13488, Q99437, P05164, P78380, O60603, P35443, P13765, P25774, P01889, P10321FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, ATP6V0B, MPO, OLR1, TLR2, THBS4, HLA-DOB, CTSS, HLA-B, HLA-CMore
Azelastinehsa04150mTOR signaling pathway1.58E-047P08069, P42338, P04049, Q02750, Q9NQL2, P51812, P49841IGF1R, PIK3CB, RAF1, MAP2K1, RRAGD, RPS6KA3, GSK3BMore
Azelastinehsa04151PI3K-Akt signaling pathway2.78E-0519P62753, P42338, P43657, O43521, P27348, P20827, Q9NRA1, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P18848, O00141, Q6ZUJ8, P30281RPS6, PIK3CB, P2RY5, BCL2L11, YWHAQ, EFNA1, PDGFC, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, ATF4, SGK, PIK3AP1, CCND3More
Azelastinehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Azelastinehsa04210Apoptosis5.90E-0513Q13315, P10415, O76075, P01375, Q9NR28, O75460, P24522, Q16548, O43521, P43234, P18848, Q14643, P04049ATM, BCL2, DFFB, TNF, DIABLO, ERN1, GADD45A, BCL2A1, BCL2L11, CTSO, ATF4, ITPR1, RAF1More
Azelastinehsa04211Longevity regulating pathway1.96E-048Q12778, P31751, P08069, Q08828, P51828, P18848, Q9UEF7, Q96KQ7FOXO1, AKT2, IGF1R, ADCY1, ADCY7, ATF4, KL, EHMT2More
Azelastinehsa04213Longevity regulating pathway - multiple species1.22E-049P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Azelastinehsa04217Necroptosis5.00E-0718P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, Q9H444, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP4B, CHMP2A, PPIDMore
Azelastinehsa04218Cellular senescence1.99E-059P01106, P31751, P04049, O75293, P30304, P06493, P0DP23, P01889, P10321MYC, AKT2, RAF1, GADD45B, CDC25A, CDK1, CALM1, HLA-B, HLA-CMore
Azelastinehsa04261Adrenergic signaling in cardiomyocytes6.89E-0712P07550, Q08828, P51828, P22694, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, Q13557, P23634ADRB2, ADCY1, ADCY7, PRKACB, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CAMK2D, ATP2B4More
Azelastinehsa04270Vascular smooth muscle contraction2.27E-037P0DP23, P04049, Q08828, P51828, P35579, P35749, P35318CALM1, RAF1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Azelastinehsa04330Notch signaling pathway9.62E-043Q92542, P49768, P46531NCSTN, PSEN1, NOTCH1More
Azelastinehsa04340Hedgehog signaling pathway8.44E-075P49841, P22694, Q13635, P49407, P10415GSK3B, PRKACB, PTCH1, ARRB1, BCL2More
Azelastinehsa04360Axon guidance1.51E-027P16333, P20827, O95631, P42338, P07332, P04049, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, RAF1, PLCG1More
Azelastinehsa04370VEGF signaling pathway1.62E-067P19174, P16298, P31751, P42338, Q05397, Q02750, P04049PLCG1, PPP3CB, AKT2, PIK3CB, PTK2, MAP2K1, RAF1More
Azelastinehsa04371Apelin signaling pathway1.47E-0714P62873, P63218, P50151, Q8WYR1, P31751, P04049, Q08828, P51828, Q13370, Q14814, Q14344, Q13485, P84022, P0DP23GNB1, GNG5, GNG10, PIK3R5, AKT2, RAF1, ADCY1, ADCY7, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, CALM1More
Azelastinehsa04380Osteoclast differentiation2.93E-0812Q9NQC7, Q9UQC2, Q16539, P23458, P42338, P31751, P01584, P14778, P08637, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, PIK3CB, AKT2, IL1B, IL1R1, FCGR3A, FCGR3B, TNF, LILRA2More
Azelastinehsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Azelastinehsa04510Focal adhesion7.22E-047P42338, O15335, P04049, P08069, Q9NRA1, P49767, Q92529PIK3CB, CHAD, RAF1, IGF1R, PDGFC, VEGFC, SHC3More
Azelastinehsa04514Cell adhesion molecules3.29E-022P01889, P10321HLA-B, HLA-CMore
Azelastinehsa04520Adherens junction8.29E-031P08069IGF1RMore
Azelastinehsa04530Tight junction3.60E-035P63261, P16989, P56750, Q92974, Q14247ACTG1, CSDA, CLDN17, ARHGEF2, CTTNMore
Azelastinehsa04540Gap junction5.06E-034P22694, P68371, P04049, Q14643PRKACB, TUBB2C, RAF1, ITPR1More
Azelastinehsa04550Signaling pathways regulating pluripotency of stem cells3.80E-042P04049, P08069RAF1, IGF1RMore
Azelastinehsa04610Complement and coagulation cascades1.15E-081P0C0L4C4AMore
Azelastinehsa04611Platelet activation4.11E-023P42338, Q14344, P07948PIK3CB, GNA13, LYNMore
Azelastinehsa04612Antigen processing and presentation2.34E-1013P13765, P48382, P01730, Q14953, P26715, P26717, Q07444, Q13241, O43908, P01732, P01889, P10321, P01375HLA-DOB, RFX5, CD4, KIR2DS5, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, HLA-B, HLA-C, TNFMore
Azelastinehsa04613Neutrophil extracellular trap formation1.29E-0926P19174, P04049, P11215, O60603, P05164, P08246, Q9UM07, Q13547, P04908, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, Q15080, P20160, P08311, P49913, P08637, O75015, P21730, P21462, P60709, O43315, Q16539PLCG1, RAF1, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, CAMP, FCGR3A, FCGR3B, C5AR1, FPR1, ACTB, AQP9, MAPK14More
Azelastinehsa04620Toll-like receptor signaling pathway6.42E-055Q13546, P01568, P01584, P31751, Q8NHW4RIPK1, IFNA21, IL1B, AKT2, CCL4L2More
Azelastinehsa04621NOD-like receptor signaling pathway4.47E-0416Q16539, Q14643, P01568, P21796, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q13546, P29728, Q05823, P01375, P09341, P12838MAPK14, ITPR1, IFNA21, VDAC1, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RIPK1, OAS2, RNASEL, TNF, CXCL1, DEFA4More
Azelastinehsa04622RIG-I-like receptor signaling pathway3.62E-045P01568, Q9NQC7, Q13546, Q12933, P10145IFNA21, CYLD, RIPK1, TRAF2, IL8More
Azelastinehsa04623Cytosolic DNA-sensing pathway4.06E-096P01584, P01568, Q13546, P25963, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, NFKBIA, POLR3H, CCL4L2More
Azelastinehsa04625C-type lectin receptor signaling pathway1.03E-069Q9ULY5, P04049, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, RAF1, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Azelastinehsa04630JAK-STAT signaling pathway8.73E-034P31751, P23458, Q13651, P04049AKT2, JAK1, IL10RA, RAF1More
Azelastinehsa04640Hematopoietic cell lineage4.13E-1017P13612, P21926, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P09603ITGA4, CD9, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, CSF1More
Azelastinehsa04650Natural killer cell mediated cytotoxicity6.76E-2423P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, Q29983, P10321, P01889, P42338, Q02750, P04049, Q13241, P26718, O14931, P08637, O75015, P26717, Q07444, Q14953, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, MICA, HLA-C, HLA-B, PIK3CB, MAP2K1, RAF1, KLRD1, KLRK1, NCR3, FCGR3A, FCGR3B, KLRC2, KLRC3, KIR2DS5, KLRC1More
Azelastinehsa04657IL-17 signaling pathway3.68E-068O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNFMore
Azelastinehsa04658Th1 and Th2 cell differentiation6.60E-2615Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Azelastinehsa04659Th17 cell differentiation4.79E-1818Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Azelastinehsa04660T cell receptor signaling pathway2.22E-1718P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Azelastinehsa04662B cell receptor signaling pathway4.64E-098P49841, P31751, P42338, P60033, P07948, P21854, Q8N149, P04049GSK3B, AKT2, PIK3CB, CD81, LYN, CD72, LILRA2, RAF1More
Azelastinehsa04664Fc epsilon RI signaling pathway4.94E-099P01375, P31751, Q16539, P42338, Q9UQC2, P07948, P19174, P04049, P09917TNF, AKT2, MAPK14, PIK3CB, GAB2, LYN, PLCG1, RAF1, ALOX5More
Azelastinehsa04666Fc gamma R-mediated phagocytosis9.04E-0613P08637, O75015, P07948, P42338, P19174, P04049, P23528, P06396, O14494, Q9UQC2, P14598, P49418, P17252FCGR3A, FCGR3B, LYN, PIK3CB, PLCG1, RAF1, CFL1, GSN, PLPP1, GAB2, NCF1, AMPH, PRKCAMore
Azelastinehsa04668TNF signaling pathway2.30E-0511P01375, O00463, Q16539, Q99941, P18848, P19875, P01584, P20749, P14780, P20333, O95429TNF, TRAF5, MAPK14, CREBL1, ATF4, CXCL2, IL1B, BCL3, MMP9, TNFRSF1B, BAG4More
Azelastinehsa04672Intestinal immune network for IgA production1.62E-023P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Azelastinehsa04713Circadian entrainment1.86E-037P0DP23, Q13557, Q02153, P61952, Q08828, P51828, P63092CALM1, CAMK2D, GUCY1B3, GNG11, ADCY1, ADCY7, GNASMore
Azelastinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Azelastinehsa04720Long-term potentiation4.06E-047P16298, P0DP23, P51812, P18848, Q08828, Q02750, P04049PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1, RAF1More
Azelastinehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Azelastinehsa04722Neurotrophin signaling pathway5.10E-059P42338, P19174, Q92529, P31751, P04049, P49841, O43524, P48023, P0DP23PIK3CB, PLCG1, SHC3, AKT2, RAF1, GSK3B, FOXO3, FASLG, CALM1More
Azelastinehsa04723Retrograde endocannabinoid signaling4.40E-025Q14643, P63218, P50151, P22694, Q16539ITPR1, GNG5, GNG10, PRKACB, MAPK14More
Azelastinehsa04724Glutamatergic synapse2.62E-044O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Azelastinehsa04725Cholinergic synapse6.81E-0610Q08828, P51828, P22694, Q14643, P63218, P50151, P18848, P42338, P31751, P10415ADCY1, ADCY7, PRKACB, ITPR1, GNG5, GNG10, ATF4, PIK3CB, AKT2, BCL2More
Azelastinehsa04726Serotonergic synapse3.87E-034P63218, P50151, P09917, P04049GNG5, GNG10, ALOX5, RAF1More
Azelastinehsa04727GABAergic synapse2.70E-043P63218, P50151, P15104GNG5, GNG10, GLULMore
Azelastinehsa04728Dopaminergic synapse4.28E-0716P63092, P14416, P63218, P50151, P61952, P31751, P49841, Q99941, P18848, Q16539, Q13557, P49407, Q13362, Q14738, P0DP23, O15516GNAS, DRD2, GNG5, GNG10, GNG11, AKT2, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, PPP2R5C, PPP2R5D, CALM1, CLOCKMore
Azelastinehsa04730Long-term depression5.05E-044Q14344, P08069, P04049, P07948GNA13, IGF1R, RAF1, LYNMore
Azelastinehsa04740Olfactory transduction9.46E-042Q9H255, P0DP23OR51E2, CALM1More
Azelastinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Azelastinehsa04744Phototransduction1.23E-042P62873, P0DP23GNB1, CALM1More
Azelastinehsa04750Inflammatory mediator regulation of TRP channels4.26E-0813P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM1More
Azelastinehsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Azelastinehsa04910Insulin signaling pathway5.48E-069P0DP23, P22694, P06737, Q92529, P04049, Q13370, P31751, P42338, P49841CALM1, PRKACB, PYGL, SHC3, RAF1, PDE3B, AKT2, PIK3CB, GSK3BMore
Azelastinehsa04911Insulin secretion1.10E-046Q08828, P51828, P63092, Q99941, P18848, Q13557ADCY1, ADCY7, GNAS, CREBL1, ATF4, CAMK2DMore
Azelastinehsa04912GnRH signaling pathway2.84E-035Q08828, P51828, P18848, P0DP23, P04049ADCY1, ADCY7, ATF4, CALM1, RAF1More
Azelastinehsa04913Ovarian steroidogenesis5.64E-054P42330, P22694, P06213, P08069AKR1C3, PRKACB, INSR, IGF1RMore
Azelastinehsa04914Progesterone-mediated oocyte maturation1.07E-048P08069, Q17RY0, P42338, Q13370, P08238, P51812, Q02750, P04049IGF1R, CPEB4, PIK3CB, PDE3B, HSP90AB1, RPS6KA3, MAP2K1, RAF1More
Azelastinehsa04915Estrogen signaling pathway2.68E-0714P04049, Q99941, P18848, Q08828, P51828, P42338, P31751, Q92529, P07900, P08238, P0DMV8, P11142, P0DP23, Q15788RAF1, CREBL1, ATF4, ADCY1, ADCY7, PIK3CB, AKT2, SHC3, HSP90AA1, HSP90AB1, HSPA1A, HSPA8, CALM1, NCOA1More
Azelastinehsa04916Melanogenesis3.17E-059P0DP23, Q9UJU2, Q08828, P51828, P17252, P49841, Q01726, P04628, P04049CALM1, LEF1, ADCY1, ADCY7, PRKCA, GSK3B, MC1R, WNT1, RAF1More
Azelastinehsa04917Prolactin signaling pathway6.79E-054P31751, P42338, P04049, P49841AKT2, PIK3CB, RAF1, GSK3BMore
Azelastinehsa04919Thyroid hormone signaling pathway9.58E-0510P49841, P19174, P04049, P42224, P22694, P60709, Q13547, O60244, Q9NVC6, P01106GSK3B, PLCG1, RAF1, STAT1, PRKACB, ACTB, HDAC1, MED14, MED17, MYCMore
Azelastinehsa04920Adipocytokine signaling pathway4.19E-021P31751AKT2More
Azelastinehsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Azelastinehsa04922Glucagon signaling pathway3.14E-036P22694, P06737, Q12778, P31751, P0DP23, Q14643PRKACB, PYGL, FOXO1, AKT2, CALM1, ITPR1More
Azelastinehsa04923Regulation of lipolysis in adipocytes8.70E-078Q08828, P51828, P07550, P06213, Q13370, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, INSR, PDE3B, PIK3CB, IRS2, AKT2More
Azelastinehsa04924Renin secretion1.74E-064P22694, P07550, Q14643, P0DP23PRKACB, ADRB2, ITPR1, CALM1More
Azelastinehsa04925Aldosterone synthesis and secretion1.35E-047Q99941, P18848, Q08828, P51828, P0DP23, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM1, CAMK2D, ATP2B4More
Azelastinehsa04926Relaxin signaling pathway6.10E-0814P31751, P42338, P63218, P50151, P18848, P22694, P49767, P14780, Q08828, P51828, P04049, Q92529, P30679, P49407AKT2, PIK3CB, GNG5, GNG10, ATF4, PRKACB, VEGFC, MMP9, ADCY1, ADCY7, RAF1, SHC3, GNA15, ARRB1More
Azelastinehsa04927Cortisol synthesis and secretion4.28E-055Q14643, P18848, Q08828, P51828, P22694ITPR1, ATF4, ADCY1, ADCY7, PRKACBMore
Azelastinehsa04928Parathyroid hormone synthesis, secretion and action5.30E-045Q14643, P22694, P23771, P04049, P10415ITPR1, PRKACB, GATA3, RAF1, BCL2More
Azelastinehsa04929GnRH secretion4.39E-064P42338, P31751, P49407, P04049PIK3CB, AKT2, ARRB1, RAF1More
Azelastinehsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Azelastinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Azelastinehsa04932Non-alcoholic fatty liver disease2.25E-0813P31751, P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, Q16718, O95298, O14521AKT2, TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHDMore
Azelastinehsa04933AGE-RAGE signaling pathway in diabetic complications4.07E-035P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Azelastinehsa04934Cushing syndrome3.41E-0610Q14643, Q99941, P18848, Q08828, P51828, P63092, P22694, O15169, Q13557, P04628ITPR1, CREBL1, ATF4, ADCY1, ADCY7, GNAS, PRKACB, AXIN1, CAMK2D, WNT1More
Azelastinehsa04935Growth hormone synthesis, secretion and action3.97E-048P19174, Q08828, P51828, P04049, P18848, P42338, P31751, Q92529PLCG1, ADCY1, ADCY7, RAF1, ATF4, PIK3CB, AKT2, SHC3More
Azelastinehsa04940Type I diabetes mellitus4.29E-044P48023, P01889, P10321, P01375FASLG, HLA-B, HLA-C, TNFMore
Azelastinehsa04960Aldosterone-regulated sodium reabsorption6.19E-043P06213, P42338, P48048INSR, PIK3CB, KCNJ1More
Azelastinehsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Azelastinehsa04964Proximal tubule bicarbonate reclamation2.17E-031P00918CA2More
Azelastinehsa04966Collecting duct acid secretion1.06E-043P02730, P00918, Q9Y666SLC4A1, CA2, SLC12A7More
Azelastinehsa04970Salivary secretion1.43E-067P07550, Q08828, P51828, P22694, Q14643, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, CALM1, CAMPMore
Azelastinehsa04971Gastric acid secretion2.02E-067Q08828, P51828, P15311, P48048, P78508, P0DP23, Q13557ADCY1, ADCY7, VIL2, KCNJ1, KCNJ10, CALM1, CAMK2DMore
Azelastinehsa04973Carbohydrate digestion and absorption4.61E-033O43451, P42338, P31751MGAM, PIK3CB, AKT2More
Azelastinehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Azelastinehsa04976Bile secretion7.42E-066O43315, Q08828, P51828, P22694, P08183, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Azelastinehsa05010Alzheimer disease1.67E-0616Q92542, O95298, P05496, P13073, P12074, Q00535, O75460, P0DP24, P0DP23, P01584, P18848, O15169, P31751, P05141, P45880, P28070NCSTN, NDUFC2, ATP5G1, COX4I1, COX6A1, CDK5, ERN1, CALM2, CALM1, IL1B, ATF4, AXIN1, AKT2, SLC25A5, VDAC2, PSMB4More
Azelastinehsa05012Parkinson disease3.89E-025P13073, P05141, O75460, P18848, P0DP24COX4I1, SLC25A5, ERN1, ATF4, CALM2More
Azelastinehsa05016Huntington disease2.84E-0410O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12More
Azelastinehsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Azelastinehsa05020Prion disease1.01E-0413P01584, P46531, P11142, Q16718, O14521, P05496, P12074, Q92736, P45880, O60282, P49841, Q99941, Q16539IL1B, NOTCH1, HSPA8, NDUFA5, SDHD, ATP5G1, COX6A1, RYR2, VDAC2, KIF5C, GSK3B, CREBL1, MAPK14More
Azelastinehsa05022Pathways of neurodegeneration - multiple diseases1.12E-0518P49841, Q16718, O95298, O14521, P13073, Q8TEV9, O75460, P18848, Q13561, P05141, P20333, Q16539, Q00535, P01584, Q08752, P0DP24, P0DP23, P28070GSK3B, NDUFA5, NDUFC2, SDHD, COX4I1, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, TNFRSF1B, MAPK14, CDK5, IL1B, PPID, CALM2, CALM1, PSMB4More
Azelastinehsa05030Cocaine addiction4.19E-021Q00535CDK5More
Azelastinehsa05031Amphetamine addiction1.07E-037P0DP23, Q13557, P22694, P63092, Q99941, P18848, Q13547CALM1, CAMK2D, PRKACB, GNAS, CREBL1, ATF4, HDAC1More
Azelastinehsa05032Morphine addiction1.13E-035P62873, P63218, P50151, Q13370, P43250GNB1, GNG5, GNG10, PDE3B, GRK6More
Azelastinehsa05034Alcoholism2.02E-069Q13547, P0DP23, P62873, P63218, P04049, Q93077, P62807, O60814, P68431HDAC1, CALM1, GNB1, GNG5, RAF1, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Azelastinehsa05100Bacterial invasion of epithelial cells3.64E-022P42338, Q92529PIK3CB, SHC3More
Azelastinehsa05110Vibrio cholerae infection4.78E-021Q99437ATP6V0BMore
Azelastinehsa05120Epithelial cell signaling in Helicobacter pylori infection1.85E-067Q16539, P09341, P19875, P19174, P25024, P25025, P07948MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYNMore
Azelastinehsa05131Shigellosis3.15E-0212P01375, O00463, P14778, Q16539, Q04759, P61088, Q9NQL2, Q9H1Y0, P12814, Q14643, P49841, P21796TNF, TRAF5, IL1R1, MAPK14, PRKCQ, UBE2N, RRAGD, ATG5, ACTN1, ITPR1, GSK3B, VDAC1More
Azelastinehsa05132Salmonella infection4.38E-0414P51617, P04049, Q9UJU2, O00471, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371IRAK1, RAF1, LEF1, EXOC5, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2CMore
Azelastinehsa05133Pertussis3.47E-041P0C0L4C4AMore
Azelastinehsa05134Legionellosis9.39E-057P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2More
Azelastinehsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Azelastinehsa05140Leishmaniasis3.48E-0613P13612, P08637, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, Q15080ITGA4, FCGR3A, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, NCF4More
Azelastinehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Azelastinehsa05144Malaria4.94E-067P60033, P69905, P68871, O60603, P01375, P35443, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Azelastinehsa05146Amoebiasis5.74E-1413P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Azelastinehsa05150Staphylococcus aureus infection2.30E-048P0C0L4, P21730, P21462, P08637, O75015, P13646, P12838, P49913C4A, C5AR1, FPR1, FCGR3A, FCGR3B, KRT13, DEFA4, CAMPMore
Azelastinehsa05152Tuberculosis8.46E-0413P04049, Q13488, Q99437, P0DP23, P48382, O60603, P31751, P10415, P13765, P25774, P01568, Q9UDY8, P51617RAF1, TCIRG1, ATP6V0B, CALM1, RFX5, TLR2, AKT2, BCL2, HLA-DOB, CTSS, IFNA21, MALT1, IRAK1More
Azelastinehsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Azelastinehsa05161Hepatitis B1.99E-021P04049RAF1More
Azelastinehsa05162Measles5.79E-038P23458, P14784, P07766, P42338, P0DMV8, P11142, P01584, Q9NP90JAK1, IL2RB, CD3E, PIK3CB, HSPA1A, HSPA8, IL1B, RAB9BMore
Azelastinehsa05163Human cytomegalovirus infection1.31E-1124P31751, P42338, P04049, P01375, P63218, P50151, Q14643, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P22694, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P04637, O00463, P30101AKT2, PIK3CB, RAF1, TNF, GNG5, GNG10, ITPR1, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, PRKACB, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5, PDIA3More
Azelastinehsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Azelastinehsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Azelastinehsa05167Kaposi sarcoma-associated herpesvirus infection7.91E-0919P31751, P42224, P42338, P01889, P10321, P62873, P62879, P63218, P50151, P19875, P19174, P16298, P04049, Q02750, P07948, P01106, Q29983, P0DP23, P0CG47AKT2, STAT1, PIK3CB, HLA-B, HLA-C, GNB1, GNB2, GNG5, GNG10, CXCL2, PLCG1, PPP3CB, RAF1, MAP2K1, LYN, MYC, MICA, CALM1, UBBMore
Azelastinehsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Azelastinehsa05169Epstein-Barr virus infection2.85E-0822P13765, P01106, Q13547, P04637, O00463, P10415, Q16539, P42338, P07948, P01889, P10321, P30101, Q13761, P24522, O75293, P42224, P48551, P01375, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TP53, TRAF5, BCL2, MAPK14, PIK3CB, LYN, HLA-B, HLA-C, PDIA3, RUNX3, GADD45A, GADD45B, STAT1, IFNAR2, TNF, OAS2, CD3E, CD3G, CD247More
Azelastinehsa05170Human immunodeficiency virus 1 infection2.89E-0928P31751, P42338, P04049, Q02750, P01889, P10321, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P17252, O00463, P30101, Q14643, P01568, P51617, O60603, P19174, P23528, Q9NQU5, P07766, P10415, Q93034, Q9Y6Q5, P20333AKT2, PIK3CB, RAF1, MAP2K1, HLA-B, HLA-C, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, TLR2, PLCG1, CFL1, PAK6, CD3E, BCL2, CUL5, AP1M2, TNFRSF1BMore
Azelastinehsa05200Pathways in cancer1.80E-0523Q13751, P42338, P08238, P42224, P19174, P01106, P43246, P84022, Q13485, P20585, Q13547, P30281, P49767, P31751, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P14784LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, MYC, MSH2, SMAD3, SMAD4, MSH3, HDAC1, CCND3, VEGFC, AKT2, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IL2RBMore
Azelastinehsa05202Transcriptional misregulation in cancer2.54E-0721Q12778, Q15532, Q13315, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522FOXO1, SS18, ATM, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45AMore
Azelastinehsa05203Viral carcinogenesis1.59E-0410P06746, P29083, Q13547, Q15283, P06396, P12814, P01889, P10321, P62807, O60814POLB, GTF2E1, HDAC1, RASA2, GSN, ACTN1, HLA-B, HLA-C, HIST1H2BC, H2BC12More
Azelastinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Azelastinehsa05205Proteoglycans in cancer2.19E-0415Q13009, Q12955, Q14643, O75369, P04049, P14780, P17252, O60603, P01375, P08069, P23588, P04628, Q13635, P22694, P08962TIAM1, ANK3, ITPR1, FLNB, RAF1, MMP9, PRKCA, TLR2, TNF, IGF1R, EIF4B, WNT1, PTCH1, PRKACB, CD63More
Azelastinehsa05206MicroRNAs in cancer1.09E-0413P30304, P09493, P15311, P21860, P01106, P61978, Q9Y4H2, P46531, Q13547, P63279, P22105, P19174, P04049CDC25A, TPM1, VIL2, ERBB3, MYC, HNRPK, IRS2, NOTCH1, HDAC1, UBE2I, TNXB, PLCG1, RAF1More
Azelastinehsa05210Colorectal cancer1.66E-021P04049RAF1More
Azelastinehsa05211Renal cell carcinoma1.29E-032P31751, P04049AKT2, RAF1More
Azelastinehsa05212Pancreatic cancer1.43E-048P42338, P31751, P04049, Q15311, P23458, P84022, Q13485, O75293PIK3CB, AKT2, RAF1, RALBP1, JAK1, SMAD3, SMAD4, GADD45BMore
Azelastinehsa05213Endometrial cancer7.68E-069O15169, P49841, Q9UJU2, P31751, P42338, Q02750, P04049, P04637, P24522AXIN1, GSK3B, LEF1, AKT2, PIK3CB, MAP2K1, RAF1, TP53, GADD45AMore
Azelastinehsa05214Glioma8.15E-0811P08069, P0DP23, Q16566, Q92529, P04049, P42338, P31751, P04637, P19174, P24522, O75293IGF1R, CALM1, CAMK4, SHC3, RAF1, PIK3CB, AKT2, TP53, PLCG1, GADD45A, GADD45BMore
Azelastinehsa05215Prostate cancer1.46E-057P08069, Q9NRA1, P49841, P08238, P42338, P04049, P27930IGF1R, PDGFC, GSK3B, HSP90AB1, PIK3CB, RAF1, IL1R2More
Azelastinehsa05216Thyroid cancer1.13E-035P01106, Q9UJU2, P04637, P24522, O75293MYC, LEF1, TP53, GADD45A, GADD45BMore
Azelastinehsa05217Basal cell carcinoma3.97E-034Q13635, Q9UJU2, P04637, P24522PTCH1, LEF1, TP53, GADD45AMore
Azelastinehsa05218Melanoma1.51E-055P08069, Q9NRA1, P31751, P42338, P04049IGF1R, PDGFC, AKT2, PIK3CB, RAF1More
Azelastinehsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Azelastinehsa05220Chronic myeloid leukemia4.90E-047Q13547, Q13485, P84022, P31751, P42338, P04049, O75293HDAC1, SMAD4, SMAD3, AKT2, PIK3CB, RAF1, GADD45BMore
Azelastinehsa05221Acute myeloid leukemia8.16E-042P31751, P04049AKT2, RAF1More
Azelastinehsa05222Small cell lung cancer4.78E-021P31751AKT2More
Azelastinehsa05223Non-small cell lung cancer3.89E-055P31751, P10826, P04049, Q9HC35, O75293AKT2, RARB, RAF1, EML4, GADD45BMore
Azelastinehsa05224Breast cancer3.67E-047P04049, P08069, P42338, P49841, Q92837, P04637, P24522RAF1, IGF1R, PIK3CB, GSK3B, FRAT1, TP53, GADD45AMore
Azelastinehsa05225Hepatocellular carcinoma1.37E-045P04049, P08069, P42338, P49841, P51531RAF1, IGF1R, PIK3CB, GSK3B, SMARCA2More
Azelastinehsa05226Gastric cancer1.61E-059P04049, Q02750, P31751, Q9UJU2, O15169, P04637, P24522, P14923, P10415RAF1, MAP2K1, AKT2, LEF1, AXIN1, TP53, GADD45A, JUP, BCL2More
Azelastinehsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Azelastinehsa05231Choline metabolism in cancer2.00E-0610P04049, P31751, P42338, Q9NRA1, Q9Y259, P19174, P23743, P49619, Q16760, O14986RAF1, AKT2, PIK3CB, PDGFC, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1BMore
Azelastinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.18E-1014P42338, O95267, P19174, P07766, P20963, P09693, P06239, P04049, O60603, P10747, Q04759, Q16539, Q9HC35, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Azelastinehsa05310Asthma3.25E-063P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Azelastinehsa05320Autoimmune thyroid disease5.64E-046P13765, P29965, P01889, P10321, P01568, P10747HLA-DOB, CD40LG, HLA-B, HLA-C, IFNA21, CD28More
Azelastinehsa05321Inflammatory bowel disease2.28E-127O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Azelastinehsa05322Systemic lupus erythematosus4.72E-0710P08637, O75015, P08311, P09871, Q93077, P62807, Q16778, O60814, P68431, P12814FCGR3A, FCGR3B, CTSG, C1S, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1More
Azelastinehsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Azelastinehsa05330Allograft rejection4.29E-044P01889, P10321, P48023, P01375HLA-B, HLA-C, FASLG, TNFMore
Azelastinehsa05332Graft-versus-host disease1.85E-118P13765, P48023, P01889, P10321, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, HLA-B, HLA-C, CD28, TNF, KLRC1, KLRD1More
Azelastinehsa05340Primary immunodeficiency1.31E-045P01730, P01732, P11912, P07766, P06239CD4, CD8A, CD79A, CD3E, LCKMore
Azelastinehsa05412Arrhythmogenic right ventricular cardiomyopathy2.17E-031P54284CACNB3More
Azelastinehsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Azelastinehsa05415Diabetic cardiomyopathy4.54E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore
Azelastinehsa05416Viral myocarditis6.58E-032P01889, P10321HLA-B, HLA-CMore
Azelastinehsa05418Fluid shear stress and atherosclerosis2.05E-0711Q16539, P31751, P42338, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23MAPK14, AKT2, PIK3CB, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1More

Community members of Azelastine (SDC: 11.40)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q9UGN5PARP2Poly [ADPNoneribose] polymerase 2Predicted00.04350.26350.24610.7947
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P21453S1PR1Sphingosine 1Nonephosphate receptor 1Predicted10.14340.38470.2211.0621
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
Q16875PFKFB36NonephosphofructoNone2Nonekinase/fructoseNone2,6Nonebisphosphatase 3Predicted10.04620.08860.23420.4345
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P11511CYP19A1AromatasePredicted00.815610.15882.5666
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P32249GPR183GNoneprotein coupled receptor 183Predicted00.0710.048500.1324
Q9H4A3WNK1Serine/threonineNoneprotein kinase WNK1Predicted00.17530.038600.1648
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
Q07817BCL2L1BclNone2Nonelike protein 1Predicted10.08720.434911.9134
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P07305H1None0Histone H1.0Predicted10.0540.080100.1872
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
Q9H228EDG8Sphingosine 1Nonephosphate receptor 5Predicted00.09250.05520.10030.2569
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P19174PLCG11Nonephosphatidylinositol 4,5Nonebisphosphate phosphodiesterase gammaNone1Predicted00.06960.039711.1142
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
Q96PH1NOX5NADPH oxidase 5Predicted00.23180.033200.1823
P06746POLBDNA polymerase betaPredicted00.45730.18680.48561.0878
P51531SMARCA2Probable global transcription activator SNF2L2Predicted00.22310.0450.13750.3391
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
Q6PL18ATAD2ATPase family AAA domainNonecontaining protein 2Predicted00.19630.051200.2006
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)