PharmaCoNets of Azelaic-acid (SPCN: 14.00 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Azelaic-acidhsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Azelaic-acidhsa00620Pyruvate metabolism3.19E-022P40926, P14550MDH2, AKR1A1More
Azelaic-acidhsa00980Metabolism of xenobiotics by cytochrome P4505.46E-032Q16772, P09211GSTA3, GSTP1More
Azelaic-acidhsa00982Drug metabolism - cytochrome P4501.06E-022Q16772, P09211GSTA3, GSTP1More
Azelaic-acidhsa00983Drug metabolism - other enzymes1.72E-022Q16772, P09211GSTA3, GSTP1More
Azelaic-acidhsa01100Metabolic pathways8.43E-0311P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1More
Azelaic-acidhsa01524Platinum drug resistance4.44E-022Q16772, P09211GSTA3, GSTP1More
Azelaic-acidhsa04064NF-kappa B signaling pathway4.09E-038P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1More
Azelaic-acidhsa04070Phosphatidylinositol signaling system1.53E-022Q86XP1, Q96DU7DGKH, ITPKCMore
Azelaic-acidhsa04071Sphingolipid signaling pathway1.90E-037P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Azelaic-acidhsa04080Neuroactive ligand-receptor interaction1.00E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Azelaic-acidhsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Azelaic-acidhsa04145Phagosome4.48E-025Q15080, P05164, O60603, P35443, P13765NCF4, MPO, TLR2, THBS4, HLA-DOBMore
Azelaic-acidhsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Azelaic-acidhsa04340Hedgehog signaling pathway2.62E-034P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Azelaic-acidhsa04610Complement and coagulation cascades3.19E-021P0C0L4C4AMore
Azelaic-acidhsa04612Antigen processing and presentation3.22E-038P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Azelaic-acidhsa04613Neutrophil extracellular trap formation5.80E-0313O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Azelaic-acidhsa04621NOD-like receptor signaling pathway2.62E-0211Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4More
Azelaic-acidhsa04650Natural killer cell mediated cytotoxicity2.96E-026O60880, P20963, Q13241, P26718, P26717, P26715SH2D1A, CD247, KLRD1, KLRK1, KLRC2, KLRC1More
Azelaic-acidhsa04657IL-17 signaling pathway3.91E-027O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Azelaic-acidhsa04658Th1 and Th2 cell differentiation5.80E-058Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOBMore
Azelaic-acidhsa04659Th17 cell differentiation1.90E-026Q04759, P13765, Q9UL17, P23771, P09693, P20963PRKCQ, HLA-DOB, TBX21, GATA3, CD3G, CD247More
Azelaic-acidhsa04660T cell receptor signaling pathway1.40E-0412P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3BMore
Azelaic-acidhsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Azelaic-acidhsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Azelaic-acidhsa04928Parathyroid hormone synthesis, secretion and action4.23E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Azelaic-acidhsa05133Pertussis2.63E-022P10145, P0C0L4IL8, C4AMore
Azelaic-acidhsa05140Leishmaniasis1.87E-027P13612, O75015, P13765, O60603, P01375, Q16539, Q15080ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MAPK14, NCF4More
Azelaic-acidhsa05146Amoebiasis3.91E-027P09341, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Azelaic-acidhsa05202Transcriptional misregulation in cancer3.09E-0316Q12778, Q13315, P14780, P27930, Q15744, Q16548, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522FOXO1, ATM, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45AMore
Azelaic-acidhsa05203Viral carcinogenesis4.62E-023Q12933, P42229, Q15283TRAF2, STAT5A, RASA2More
Azelaic-acidhsa05204Chemical carcinogenesis5.46E-032Q16772, P09211GSTA3, GSTP1More
Azelaic-acidhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.84E-025P20963, P09693, O60603, P10747, Q04759CD247, CD3G, TLR2, CD28, PRKCQMore
Azelaic-acidhsa05310Asthma2.81E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Azelaic-acidhsa05321Inflammatory bowel disease1.22E-056O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Azelaic-acidhsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Azelaic-acidhsa05332Graft-versus-host disease3.96E-045P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More

Community members of Azelaic-acid (SDC: 2.51)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)