PharmaCoNets

PharmaCoNets of Azathioprine (S_PCN: 14.62 )

Azathioprine regulated-network (S_DN: 13.30)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Azathioprine

hsa00030

Pentose phosphate pathway

7.84E-03

P06744, P37837

GPI, TALDO1

Azathioprine

hsa00220

Arginine biosynthesis

8.55E-05

P05089, P49448

ARG1, GLUD2

Azathioprine

hsa00240

Pyrimidine metabolism

4.78E-02

P21589

NT5E

Azathioprine

hsa00330

Arginine and proline metabolism

4.86E-02

P17707

AMD1

Azathioprine

hsa00430

Taurine and hypotaurine metabolism

2.38E-02

Q6ZQY3, Q14032

GADL1, BAAT

Azathioprine

hsa00760

Nicotinate and nicotinamide metabolism

2.42E-02

P21589

NT5E

Azathioprine

hsa00970

Aminoacyl-tRNA biosynthesis

1.99E-03

O95363, P14868, Q15046

FARS2, DARS, KARS

Azathioprine

hsa01200

Carbon metabolism

7.69E-03

P06744, P37837, P40926

GPI, TALDO1, MDH2

Azathioprine

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.01E-02

P49841, P42338, Q9NRA1

GSK3B, PIK3CB, PDGFC

Azathioprine

hsa01523

Antifolate resistance

2.83E-02

P41440, Q92820, P01375

SLC19A1, GGH, TNF

Azathioprine

hsa01524

Platinum drug resistance

2.42E-02

Q13315

ATM

Azathioprine

hsa02010

ABC transporters

2.42E-02

P45844

ABCG1

Azathioprine

hsa03020

RNA polymerase

4.94E-02

P24928, P62487

POLR2A, POLR2G

Azathioprine

hsa03060

Protein export

5.88E-04

P37108, Q15005

SRP14, SPCS2

Azathioprine

hsa03410

Base excision repair

7.59E-03

P27695

APEX1

Azathioprine

hsa03440

Homologous recombination

1.81E-02

Q13315

ATM

Azathioprine

hsa04014

Ras signaling pathway

4.14E-04

P42338, Q9NRA1, Q13009, P11233, Q15283, P61586, P62873, P63218, P50151

PIK3CB, PDGFC, TIAM1, RALA, RASA2, RHOA, GNB1, GNG5, GNG10

Azathioprine

hsa04015

Rap1 signaling pathway

2.64E-02

P11233, Q13009

RALA, TIAM1

Azathioprine

hsa04020

Calcium signaling pathway

4.45E-02

P0DP24, P51828, P23634

CALM2, ADCY7, ATP2B4

Azathioprine

hsa04024

cAMP signaling pathway

3.79E-02

P51828, P0DP24, P23634

ADCY7, CALM2, ATP2B4

Azathioprine

hsa04061

Viral protein interaction with cytokine and cytokine receptor

3.75E-03

P09341, P19875, P25024, Q13651, P14784, P09603, P01375

CXCL1, CXCL2, CXCR1, IL10RA, IL2RB, CSF1, TNF

Azathioprine

hsa04062

Chemokine signaling pathway

7.52E-04

P25024, P09341, P19875, P07948, P42338, P63218, P50151, P43250, Q08881, P22694, P49841

CXCR1, CXCL1, CXCL2, LYN, PIK3CB, GNG5, GNG10, GRK6, ITK, PRKACB, GSK3B

Azathioprine

hsa04064

NF-kappa B signaling pathway

4.21E-02

Q13315

ATM

Azathioprine

hsa04068

FoxO signaling pathway

3.91E-02

Q13315

ATM

Azathioprine

hsa04071

Sphingolipid signaling pathway

2.00E-03

P21453, Q9H228, P01375, Q13510, Q13362, Q9BX95, P10415, Q9UQC2

S1PR1, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, BCL2, GAB2

Azathioprine

hsa04110

Cell cycle

3.01E-02

Q13315

ATM

Azathioprine

hsa04114

Oocyte meiosis

1.64E-04

Q13557, P0DP24, Q08828, P51828, P27348, Q13362

CAMK2D, CALM2, ADCY1, ADCY7, YWHAQ, PPP2R5C

Azathioprine

hsa04115

p53 signaling pathway

1.51E-02

Q13315

ATM

Azathioprine

hsa04140

Autophagy - animal

3.72E-02

P22694, Q14643, P10415, Q9H1Y0, Q04759

PRKACB, ITPR1, BCL2, ATG5, PRKCQ

Azathioprine

hsa04151

PI3K-Akt signaling pathway

4.04E-02

P42338, P49841, Q9NRA1, P63218, P50151, P14784

PIK3CB, GSK3B, PDGFC, GNG5, GNG10, IL2RB

Azathioprine

hsa04210

Apoptosis

3.91E-02

Q13315

ATM

Azathioprine

hsa04217

Necroptosis

1.46E-02

P23458, Q9NQC7, P07900, P01584, Q13557, Q9H444

JAK1, CYLD, HSP90AA1, IL1B, CAMK2D, CHMP4B

Azathioprine

hsa04261

Adrenergic signaling in cardiomyocytes

1.04E-03

Q08828, P51828, Q13362, P0DP24, Q13557, P23634

ADCY1, ADCY7, PPP2R5C, CALM2, CAMK2D, ATP2B4

Azathioprine

hsa04270

Vascular smooth muscle contraction

3.27E-05

Q05655, P0DP24, Q08828, P51828, P35579, P35318

PRKCD, CALM2, ADCY1, ADCY7, MYH9, ADM

Azathioprine

hsa04380

Osteoclast differentiation

2.67E-02

Q9NQC7, Q9UQC2, P23458, P01584

CYLD, GAB2, JAK1, IL1B

Azathioprine

hsa04610

Complement and coagulation cascades

8.69E-03

P00734, P0C0L4, P12259, P20023

F2, C4A, F5, CR2

Azathioprine

hsa04612

Antigen processing and presentation

9.93E-07

P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, P01732, P30101, P01375

HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, PDIA3, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P61225	RAP2B	Ras-related protein Rap-2b	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.788
P10114	RAP2A	Ras-related protein Rap-2a	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.788
Q9UM07	PADI4	Protein-arginine deiminase type-4	P48382	RFX5	DNA-binding protein RFX5	-0.782
P61225	RAP2B	Ras-related protein Rap-2b	P01730	CD4	T-cell surface glycoprotein CD4	0.784
P10114	RAP2A	Ras-related protein Rap-2a	P01730	CD4	T-cell surface glycoprotein CD4	0.784
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P61225	RAP2B	Ras-related protein Rap-2b	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.737
P10114	RAP2A	Ras-related protein Rap-2a	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.737
O14966	RAB29	Ras-related protein Rab-7L1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.804
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.874
P61225	RAP2B	Ras-related protein Rap-2b	P26717	KLRC2	NKG2-C type II integral membrane protein	0.737
P10114	RAP2A	Ras-related protein Rap-2a	P26717	KLRC2	NKG2-C type II integral membrane protein	0.737
O14966	RAB29	Ras-related protein Rab-7L1	P26717	KLRC2	NKG2-C type II integral membrane protein	0.804
O14966	RAB29	Ras-related protein Rab-7L1	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.872
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P61225	RAP2B	Ras-related protein Rap-2b	Q13241	KLRD1	Natural killer cells antigen CD94	0.721
P10114	RAP2A	Ras-related protein Rap-2a	Q13241	KLRD1	Natural killer cells antigen CD94	0.721
O14966	RAB29	Ras-related protein Rab-7L1	Q13241	KLRD1	Natural killer cells antigen CD94	0.865
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P61225	RAP2B	Ras-related protein Rap-2b	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.726
P10114	RAP2A	Ras-related protein Rap-2a	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.726
O14966	RAB29	Ras-related protein Rab-7L1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.796
P61225	RAP2B	Ras-related protein Rap-2b	P30101	PDIA3	Protein disulfide-isomerase A3	0.743
P10114	RAP2A	Ras-related protein Rap-2a	P30101	PDIA3	Protein disulfide-isomerase A3	0.743
O14966	RAB29	Ras-related protein Rab-7L1	P30101	PDIA3	Protein disulfide-isomerase A3	0.732
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
O14966	RAB29	Ras-related protein Rab-7L1	P01375	TNF	Tumor necrosis factor	-0.722

Azathioprine

hsa04613

Neutrophil extracellular trap formation

4.94E-02

O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, P49913, P21730, P21462

TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1

Azathioprine

hsa04640

Hematopoietic cell lineage

1.83E-10

P13612, P27930, P11215, P15144, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375, P09603

ITGA4, IL1R2, ITGAM, ANPEP, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF, CSF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13612	ITGA4	Integrin alpha-4	-0.74
P61225	RAP2B	Ras-related protein Rap-2b	P13612	ITGA4	Integrin alpha-4	0.869
P10114	RAP2A	Ras-related protein Rap-2a	P13612	ITGA4	Integrin alpha-4	0.869
O14966	RAB29	Ras-related protein Rab-7L1	P13612	ITGA4	Integrin alpha-4	0.807
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
O14966	RAB29	Ras-related protein Rab-7L1	P11215	ITGAM	Integrin alpha-M	-0.713
Q9UM07	PADI4	Protein-arginine deiminase type-4	P15144	ANPEP	Aminopeptidase N	0.76
P61225	RAP2B	Ras-related protein Rap-2b	P20023	CR2	Complement receptor type 2	0.811
P10114	RAP2A	Ras-related protein Rap-2a	P20023	CR2	Complement receptor type 2	0.811
P61225	RAP2B	Ras-related protein Rap-2b	P11836	MS4A1	B-lymphocyte antigen CD20	0.744
P10114	RAP2A	Ras-related protein Rap-2a	P11836	MS4A1	B-lymphocyte antigen CD20	0.744
Q9UM07	PADI4	Protein-arginine deiminase type-4	P25063	CD24	Signal transducer CD24	0.866
P61225	RAP2B	Ras-related protein Rap-2b	P25063	CD24	Signal transducer CD24	-0.707
P10114	RAP2A	Ras-related protein Rap-2a	P25063	CD24	Signal transducer CD24	-0.707
O14966	RAB29	Ras-related protein Rab-7L1	P25063	CD24	Signal transducer CD24	-0.908
P61225	RAP2B	Ras-related protein Rap-2b	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.902
P10114	RAP2A	Ras-related protein Rap-2a	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.902
O14966	RAB29	Ras-related protein Rab-7L1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.789
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P61225	RAP2B	Ras-related protein Rap-2b	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.827
P10114	RAP2A	Ras-related protein Rap-2a	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.827
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P61225	RAP2B	Ras-related protein Rap-2b	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.726
P10114	RAP2A	Ras-related protein Rap-2a	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.726
O14966	RAB29	Ras-related protein Rab-7L1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.796
P61225	RAP2B	Ras-related protein Rap-2b	P01730	CD4	T-cell surface glycoprotein CD4	0.784
P10114	RAP2A	Ras-related protein Rap-2a	P01730	CD4	T-cell surface glycoprotein CD4	0.784
P61225	RAP2B	Ras-related protein Rap-2b	P09564	CD7	T-cell antigen CD7	0.751
P10114	RAP2A	Ras-related protein Rap-2a	P09564	CD7	T-cell antigen CD7	0.751
O14966	RAB29	Ras-related protein Rab-7L1	P09564	CD7	T-cell antigen CD7	0.731
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P61225	RAP2B	Ras-related protein Rap-2b	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.788
P10114	RAP2A	Ras-related protein Rap-2a	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.788
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
O14966	RAB29	Ras-related protein Rab-7L1	P01375	TNF	Tumor necrosis factor	-0.722
P61225	RAP2B	Ras-related protein Rap-2b	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.807
P10114	RAP2A	Ras-related protein Rap-2a	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.807
O14966	RAB29	Ras-related protein Rab-7L1	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.702

Azathioprine

hsa04650

Natural killer cell mediated cytotoxicity

1.09E-09

P01375, P06239, O60880, P20963, Q29983, P10321, P01889, Q13241, P26718, O14931, P26717, Q07444, P26715

TNF, LCK, SH2D1A, CD247, MICA, HLA-C, HLA-B, KLRD1, KLRK1, NCR3, KLRC2, KLRC3, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O14966	RAB29	Ras-related protein Rab-7L1	P01375	TNF	Tumor necrosis factor	-0.722
P61225	RAP2B	Ras-related protein Rap-2b	P06239	LCK	Tyrosine-protein kinase Lck	0.9
P10114	RAP2A	Ras-related protein Rap-2a	P06239	LCK	Tyrosine-protein kinase Lck	0.9
O14966	RAB29	Ras-related protein Rab-7L1	P06239	LCK	Tyrosine-protein kinase Lck	0.856
P61225	RAP2B	Ras-related protein Rap-2b	O60880	SH2D1A	SH2 domain-containing protein 1A	0.794
P10114	RAP2A	Ras-related protein Rap-2a	O60880	SH2D1A	SH2 domain-containing protein 1A	0.794
O14966	RAB29	Ras-related protein Rab-7L1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.811
P61225	RAP2B	Ras-related protein Rap-2b	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.835
P10114	RAP2A	Ras-related protein Rap-2a	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.835
O14966	RAB29	Ras-related protein Rab-7L1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.937
P84095	RHOG	Rho-related GTP-binding protein RhoG	Q29983	MICA	MHC class I polypeptide-related sequence A	0.797
P84095	RHOG	Rho-related GTP-binding protein RhoG	P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	0.797
P84095	RHOG	Rho-related GTP-binding protein RhoG	P01889	HLA-B	HLA class I histocompatibility antigen, B alpha chain	0.797
P61225	RAP2B	Ras-related protein Rap-2b	Q13241	KLRD1	Natural killer cells antigen CD94	0.721
P10114	RAP2A	Ras-related protein Rap-2a	Q13241	KLRD1	Natural killer cells antigen CD94	0.721
O14966	RAB29	Ras-related protein Rab-7L1	Q13241	KLRD1	Natural killer cells antigen CD94	0.865
P61225	RAP2B	Ras-related protein Rap-2b	P26718	KLRK1	NKG2-D type II integral membrane protein	0.851
P10114	RAP2A	Ras-related protein Rap-2a	P26718	KLRK1	NKG2-D type II integral membrane protein	0.851
O14966	RAB29	Ras-related protein Rab-7L1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.847
P61225	RAP2B	Ras-related protein Rap-2b	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.73
P10114	RAP2A	Ras-related protein Rap-2a	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.73
O14966	RAB29	Ras-related protein Rab-7L1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.852
P61225	RAP2B	Ras-related protein Rap-2b	P26717	KLRC2	NKG2-C type II integral membrane protein	0.737
P10114	RAP2A	Ras-related protein Rap-2a	P26717	KLRC2	NKG2-C type II integral membrane protein	0.737
O14966	RAB29	Ras-related protein Rab-7L1	P26717	KLRC2	NKG2-C type II integral membrane protein	0.804
O14966	RAB29	Ras-related protein Rab-7L1	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.872
P61225	RAP2B	Ras-related protein Rap-2b	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.737
P10114	RAP2A	Ras-related protein Rap-2a	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.737
O14966	RAB29	Ras-related protein Rab-7L1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.804

Azathioprine

hsa04658

Th1 and Th2 cell differentiation

1.14E-12

Q04759, P07766, P20963, P09693, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P61225	RAP2B	Ras-related protein Rap-2b	Q04759	PRKCQ	Protein kinase C theta type	0.755
P10114	RAP2A	Ras-related protein Rap-2a	Q04759	PRKCQ	Protein kinase C theta type	0.755
O14966	RAB29	Ras-related protein Rab-7L1	Q04759	PRKCQ	Protein kinase C theta type	0.774
P61225	RAP2B	Ras-related protein Rap-2b	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.902
P10114	RAP2A	Ras-related protein Rap-2a	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.902
O14966	RAB29	Ras-related protein Rab-7L1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.789
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P61225	RAP2B	Ras-related protein Rap-2b	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.835
P10114	RAP2A	Ras-related protein Rap-2a	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.835
O14966	RAB29	Ras-related protein Rab-7L1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.937
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P61225	RAP2B	Ras-related protein Rap-2b	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.827
P10114	RAP2A	Ras-related protein Rap-2a	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.827
P61225	RAP2B	Ras-related protein Rap-2b	P01730	CD4	T-cell surface glycoprotein CD4	0.784
P10114	RAP2A	Ras-related protein Rap-2a	P01730	CD4	T-cell surface glycoprotein CD4	0.784
P61225	RAP2B	Ras-related protein Rap-2b	P06239	LCK	Tyrosine-protein kinase Lck	0.9
P10114	RAP2A	Ras-related protein Rap-2a	P06239	LCK	Tyrosine-protein kinase Lck	0.9
O14966	RAB29	Ras-related protein Rab-7L1	P06239	LCK	Tyrosine-protein kinase Lck	0.856
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
O14966	RAB29	Ras-related protein Rab-7L1	Q14765	STAT4	Signal transducer and activator of transcription 4	0.775
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P61225	RAP2B	Ras-related protein Rap-2b	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.762
P10114	RAP2A	Ras-related protein Rap-2a	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.762
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P61225	RAP2B	Ras-related protein Rap-2b	Q9UL17	TBX21	T-box transcription factor TBX21	0.833
P10114	RAP2A	Ras-related protein Rap-2a	Q9UL17	TBX21	T-box transcription factor TBX21	0.833
O14966	RAB29	Ras-related protein Rab-7L1	Q9UL17	TBX21	T-box transcription factor TBX21	0.897
O14966	RAB29	Ras-related protein Rab-7L1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.753
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P61225	RAP2B	Ras-related protein Rap-2b	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.788
P10114	RAP2A	Ras-related protein Rap-2a	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.788
P61225	RAP2B	Ras-related protein Rap-2b	Q13761	RUNX3	Runt-related transcription factor 3	0.766
P10114	RAP2A	Ras-related protein Rap-2a	Q13761	RUNX3	Runt-related transcription factor 3	0.766
O14966	RAB29	Ras-related protein Rab-7L1	Q13761	RUNX3	Runt-related transcription factor 3	0.955

Azathioprine

hsa04659

Th17 cell differentiation

6.26E-07

Q04759, P01730, P06239, P14784, P13765, Q9UL17, P23771, P07766, P09693, P20963

PRKCQ, CD4, LCK, IL2RB, HLA-DOB, TBX21, GATA3, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P61225	RAP2B	Ras-related protein Rap-2b	Q04759	PRKCQ	Protein kinase C theta type	0.755
P10114	RAP2A	Ras-related protein Rap-2a	Q04759	PRKCQ	Protein kinase C theta type	0.755
O14966	RAB29	Ras-related protein Rab-7L1	Q04759	PRKCQ	Protein kinase C theta type	0.774
P61225	RAP2B	Ras-related protein Rap-2b	P01730	CD4	T-cell surface glycoprotein CD4	0.784
P10114	RAP2A	Ras-related protein Rap-2a	P01730	CD4	T-cell surface glycoprotein CD4	0.784
P61225	RAP2B	Ras-related protein Rap-2b	P06239	LCK	Tyrosine-protein kinase Lck	0.9
P10114	RAP2A	Ras-related protein Rap-2a	P06239	LCK	Tyrosine-protein kinase Lck	0.9
O14966	RAB29	Ras-related protein Rab-7L1	P06239	LCK	Tyrosine-protein kinase Lck	0.856
O14966	RAB29	Ras-related protein Rab-7L1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.753
P61225	RAP2B	Ras-related protein Rap-2b	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.788
P10114	RAP2A	Ras-related protein Rap-2a	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.788
P61225	RAP2B	Ras-related protein Rap-2b	Q9UL17	TBX21	T-box transcription factor TBX21	0.833
P10114	RAP2A	Ras-related protein Rap-2a	Q9UL17	TBX21	T-box transcription factor TBX21	0.833
O14966	RAB29	Ras-related protein Rab-7L1	Q9UL17	TBX21	T-box transcription factor TBX21	0.897
P61225	RAP2B	Ras-related protein Rap-2b	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.762
P10114	RAP2A	Ras-related protein Rap-2a	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.762
P61225	RAP2B	Ras-related protein Rap-2b	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.902
P10114	RAP2A	Ras-related protein Rap-2a	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.902
O14966	RAB29	Ras-related protein Rab-7L1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.789
P61225	RAP2B	Ras-related protein Rap-2b	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.827
P10114	RAP2A	Ras-related protein Rap-2a	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.827
P61225	RAP2B	Ras-related protein Rap-2b	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.835
P10114	RAP2A	Ras-related protein Rap-2a	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.835
O14966	RAB29	Ras-related protein Rab-7L1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.937

Azathioprine

hsa04660

T cell receptor signaling pathway

1.75E-09

P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239

TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
O14966	RAB29	Ras-related protein Rab-7L1	P01375	TNF	Tumor necrosis factor	-0.722
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.779
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P61225	RAP2B	Ras-related protein Rap-2b	Q04759	PRKCQ	Protein kinase C theta type	0.755
P10114	RAP2A	Ras-related protein Rap-2a	Q04759	PRKCQ	Protein kinase C theta type	0.755
O14966	RAB29	Ras-related protein Rab-7L1	Q04759	PRKCQ	Protein kinase C theta type	0.774
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.799
P61225	RAP2B	Ras-related protein Rap-2b	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.788
P10114	RAP2A	Ras-related protein Rap-2a	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.788
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P61225	RAP2B	Ras-related protein Rap-2b	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.766
P10114	RAP2A	Ras-related protein Rap-2a	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.766
O14966	RAB29	Ras-related protein Rab-7L1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.78
P61225	RAP2B	Ras-related protein Rap-2b	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.902
P10114	RAP2A	Ras-related protein Rap-2a	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.902
O14966	RAB29	Ras-related protein Rab-7L1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.789
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P61225	RAP2B	Ras-related protein Rap-2b	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.835
P10114	RAP2A	Ras-related protein Rap-2a	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.835
O14966	RAB29	Ras-related protein Rab-7L1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.937
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P61225	RAP2B	Ras-related protein Rap-2b	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.827
P10114	RAP2A	Ras-related protein Rap-2a	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.827
P61225	RAP2B	Ras-related protein Rap-2b	P01730	CD4	T-cell surface glycoprotein CD4	0.784
P10114	RAP2A	Ras-related protein Rap-2a	P01730	CD4	T-cell surface glycoprotein CD4	0.784
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P61225	RAP2B	Ras-related protein Rap-2b	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.726
P10114	RAP2A	Ras-related protein Rap-2a	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.726
O14966	RAB29	Ras-related protein Rab-7L1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.796
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.796
O14966	RAB29	Ras-related protein Rab-7L1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.907
P61225	RAP2B	Ras-related protein Rap-2b	P06239	LCK	Tyrosine-protein kinase Lck	0.9
P10114	RAP2A	Ras-related protein Rap-2a	P06239	LCK	Tyrosine-protein kinase Lck	0.9
O14966	RAB29	Ras-related protein Rab-7L1	P06239	LCK	Tyrosine-protein kinase Lck	0.856

Azathioprine

hsa04662

B cell receptor signaling pathway

3.86E-03

P49841, P42338, P07948, Q8N149

GSK3B, PIK3CB, LYN, LILRA2

Azathioprine

hsa04664

Fc epsilon RI signaling pathway

1.01E-02

P42338, P07948, P09917

PIK3CB, LYN, ALOX5

Azathioprine

hsa04672

Intestinal immune network for IgA production

1.66E-02

P10747, P13765, P13612

CD28, HLA-DOB, ITGA4

Azathioprine

hsa04710

Circadian rhythm

2.43E-02

O15516

CLOCK

Azathioprine

hsa04713

Circadian entrainment

7.61E-04

O15399, P0DP24, Q13557, P63218, P50151, Q08828, P51828

GRIN2D, CALM2, CAMK2D, GNG5, GNG10, ADCY1, ADCY7

Azathioprine

hsa04722

Neurotrophin signaling pathway

3.69E-03

Q05655, Q15418, P52566

PRKCD, RPS6KA1, ARHGDIB

Azathioprine

hsa04723

Retrograde endocannabinoid signaling

5.51E-03

P48169, P28472, P62873, P63218, P50151, P22694

GABRA4, GABRB3, GNB1, GNG5, GNG10, PRKACB

Azathioprine

hsa04724

Glutamatergic synapse

1.93E-03

O15399, P63218, P50151, P15104

GRIN2D, GNG5, GNG10, GLUL

Azathioprine

hsa04725

Cholinergic synapse

1.84E-02

P63218, P50151, P42338

GNG5, GNG10, PIK3CB

Azathioprine

hsa04726

Serotonergic synapse

2.25E-03

P22694, P63218, P50151, P09917, P28472

PRKACB, GNG5, GNG10, ALOX5, GABRB3

Azathioprine

hsa04727

GABAergic synapse

9.87E-05

P62873, P63218, P50151, P48169, P28472, P15104, P22694

GNB1, GNG5, GNG10, GABRA4, GABRB3, GLUL, PRKACB

Azathioprine

hsa04742

Taste transduction

4.80E-02

P48169

GABRA4

Azathioprine

hsa04750

Inflammatory mediator regulation of TRP channels

1.65E-03

P01584, Q08828, P51828, Q13557, P0DP24

IL1B, ADCY1, ADCY7, CAMK2D, CALM2

Azathioprine

hsa04911

Insulin secretion

3.98E-02

Q08828, P51828, Q13557

ADCY1, ADCY7, CAMK2D

Azathioprine

hsa04912

GnRH signaling pathway

1.93E-02

Q08828, P51828, Q13557, P0DP24

ADCY1, ADCY7, CAMK2D, CALM2

Azathioprine

hsa04916

Melanogenesis

5.19E-03

Q13557, P0DP24, Q08828, P51828

CAMK2D, CALM2, ADCY1, ADCY7

Azathioprine

hsa04921

Oxytocin signaling pathway

9.45E-03

P0DP24, Q08828, P51828, Q13557, Q96RR4

CALM2, ADCY1, ADCY7, CAMK2D, CAMKK2

Azathioprine

hsa04924

Renin secretion

3.64E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Azathioprine

hsa04925

Aldosterone synthesis and secretion

6.88E-04

Q08828, P51828, P0DP24, Q13557, P23634

ADCY1, ADCY7, CALM2, CAMK2D, ATP2B4

Azathioprine

hsa04927

Cortisol synthesis and secretion

1.66E-02

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Azathioprine

hsa04931

Insulin resistance

1.59E-02

Q05655, Q15418

PRKCD, RPS6KA1

Azathioprine

hsa04932

Non-alcoholic fatty liver disease

2.29E-02

O43521, O75460, P01584, P12074, O15239

BCL2L11, ERN1, IL1B, COX6A1, NDUFA1

Azathioprine

hsa04940

Type I diabetes mellitus

9.79E-03

P10747, P13765, P01889, P10321, P01375

CD28, HLA-DOB, HLA-B, HLA-C, TNF

Azathioprine

hsa04961

Endocrine and other factor-regulated calcium reabsorption

2.09E-02

P23634, P62491

ATP2B4, RAB11A

Azathioprine

hsa04970

Salivary secretion

7.13E-05

P07550, Q08828, P51828, P22694, Q14643, P23634, P0DP24, P49913

ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B4, CALM2, CAMP

Azathioprine

hsa04971

Gastric acid secretion

2.81E-03

Q08828, P51828, P0DP24, Q13557

ADCY1, ADCY7, CALM2, CAMK2D

Azathioprine

hsa04972

Pancreatic secretion

6.17E-04

P23634, Q08828, P51828, P62491

ATP2B4, ADCY1, ADCY7, RAB11A

Azathioprine

hsa04976

Bile secretion

1.65E-02

Q08828, P51828, Q14032

ADCY1, ADCY7, BAAT

Azathioprine

hsa05032

Morphine addiction

5.16E-04

P22694, P62873, P63218, P50151, P48169, P28472, P43250

PRKACB, GNB1, GNG5, GNG10, GABRA4, GABRB3, GRK6

Azathioprine

hsa05033

Nicotine addiction

2.43E-02

P48169

GABRA4

Azathioprine

hsa05034

Alcoholism

4.87E-03

O15399, P22694, Q13547, P63218, P50151, P62807, Q16778

GRIN2D, PRKACB, HDAC1, GNG5, GNG10, HIST1H2BC, HIST2H2BE

Azathioprine

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.62E-02

P09341, P19875, P25024, P07948

CXCL1, CXCL2, CXCR1, LYN

Azathioprine

hsa05133

Pertussis

4.23E-02

P10145, P0C0L4, Q02556

IL8, C4A, IRF8

Azathioprine

hsa05134

Legionellosis

1.74E-02

P11215, P01375, P09341, P19875

ITGAM, TNF, CXCL1, CXCL2

Azathioprine

hsa05144

Malaria

2.21E-03

P60033, O60603, P01375, P35443, P26718

CD81, TLR2, TNF, THBS4, KLRK1

Azathioprine

hsa05146

Amoebiasis

5.29E-06

P09341, P19875, P27930, P01375, O60603, P11215, P05089, P30679, P22694, P12814, P08311

CXCL1, CXCL2, IL1R2, TNF, TLR2, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSG

Azathioprine

hsa05160

Hepatitis C

3.91E-02

P20591

MX1

Azathioprine

hsa05162

Measles

4.50E-02

P20591

MX1

Azathioprine

hsa05163

Human cytomegalovirus infection

1.26E-02

P42338, P63218, P50151, P49841, P14778

PIK3CB, GNG5, GNG10, GSK3B, IL1R1

Azathioprine

hsa05165

Human papillomavirus infection

1.20E-03

P20591, P01889, P10321, P30153, Q13315

MX1, HLA-B, HLA-C, PPP2R1A, ATM

Azathioprine

hsa05167

Kaposi sarcoma-associated herpesvirus infection

3.79E-04

P42338, P01889, P10321, P49841, P63218, P50151, P07948, Q29983

PIK3CB, HLA-B, HLA-C, GSK3B, GNG5, GNG10, LYN, MICA

Azathioprine

hsa05169

Epstein-Barr virus infection

1.18E-05

P20023, P13765, P01106, O00463, O00232, P30101, Q13761, P24522, P29728, P07766, P09693, P20963

CR2, HLA-DOB, MYC, TRAF5, PSMD12, PDIA3, RUNX3, GADD45A, OAS2, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P61225	RAP2B	Ras-related protein Rap-2b	P20023	CR2	Complement receptor type 2	0.811
P10114	RAP2A	Ras-related protein Rap-2a	P20023	CR2	Complement receptor type 2	0.811
P61225	RAP2B	Ras-related protein Rap-2b	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.788
P10114	RAP2A	Ras-related protein Rap-2a	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.788
P61225	RAP2B	Ras-related protein Rap-2b	P01106	MYC	Myc proto-oncogene protein	0.783
P10114	RAP2A	Ras-related protein Rap-2a	P01106	MYC	Myc proto-oncogene protein	0.783
P61225	RAP2B	Ras-related protein Rap-2b	O00463	TRAF5	TNF receptor-associated factor 5	0.733
P10114	RAP2A	Ras-related protein Rap-2a	O00463	TRAF5	TNF receptor-associated factor 5	0.733
P61225	RAP2B	Ras-related protein Rap-2b	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.731
P61225	RAP2B	Ras-related protein Rap-2b	P30101	PDIA3	Protein disulfide-isomerase A3	0.743
P10114	RAP2A	Ras-related protein Rap-2a	P30101	PDIA3	Protein disulfide-isomerase A3	0.743
P61225	RAP2B	Ras-related protein Rap-2b	Q13761	RUNX3	Runt-related transcription factor 3	0.766
P10114	RAP2A	Ras-related protein Rap-2a	Q13761	RUNX3	Runt-related transcription factor 3	0.766
P61225	RAP2B	Ras-related protein Rap-2b	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.76
P10114	RAP2A	Ras-related protein Rap-2a	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.76
P61225	RAP2B	Ras-related protein Rap-2b	P29728	OAS2	2'-5'-oligoadenylate synthase 2	0.786
P10114	RAP2A	Ras-related protein Rap-2a	P29728	OAS2	2'-5'-oligoadenylate synthase 2	0.786
P61225	RAP2B	Ras-related protein Rap-2b	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.902
P10114	RAP2A	Ras-related protein Rap-2a	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.902
P61225	RAP2B	Ras-related protein Rap-2b	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.827
P10114	RAP2A	Ras-related protein Rap-2a	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.827
P61225	RAP2B	Ras-related protein Rap-2b	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.835
P10114	RAP2A	Ras-related protein Rap-2a	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.835

Azathioprine

hsa05202

Transcriptional misregulation in cancer

3.71E-02

P14780, P27930, Q15744, Q16548, P35226, P05164, P12838, P08246, Q9C0K0, P12980, P24522

MMP9, IL1R2, CEBPE, BCL2A1, BMI1, MPO, DEFA4, ELA2, BCL11B, LYL1, GADD45A

Azathioprine

hsa05218

Melanoma

3.80E-02

Q9NRA1, P42338

PDGFC, PIK3CB

Azathioprine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

4.39E-05

O95267, P07766, P20963, P09693, P06239, Q04759, P01730

RASGRP1, CD3E, CD247, CD3G, LCK, PRKCQ, CD4

Azathioprine

hsa05310

Asthma

1.66E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Azathioprine

hsa05320

Autoimmune thyroid disease

1.25E-02

P01889, P10321

HLA-B, HLA-C

Azathioprine

hsa05321

Inflammatory bowel disease

1.14E-03

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Azathioprine

hsa05322

Systemic lupus erythematosus

4.51E-02

P08311, P01375, P62807, Q16778, P12814

CTSG, TNF, HIST1H2BC, HIST2H2BE, ACTN1

Azathioprine

hsa05323

Rheumatoid arthritis

5.25E-05

P01375, Q06643, P09603, P13765, P10747, P09341, P19875, O60603

TNF, LTB, CSF1, HLA-DOB, CD28, CXCL1, CXCL2, TLR2

Azathioprine

hsa05330

Allograft rejection

1.25E-02

P01889, P10321

HLA-B, HLA-C

Azathioprine

hsa05332

Graft-versus-host disease

5.91E-06

P13765, P01889, P10321, P10747, P01375, P26715, Q13241

HLA-DOB, HLA-B, HLA-C, CD28, TNF, KLRC1, KLRD1

Azathioprine

hsa05340

Primary immunodeficiency

7.58E-04

P01730, P01732, P07766, P06239

CD4, CD8A, CD3E, LCK

Azathioprine

hsa05414

Dilated cardiomyopathy

2.68E-02

P09493, P26678

TPM1, PLN

Azathioprine

hsa05416

Viral myocarditis

1.96E-02

P01889, P10321

HLA-B, HLA-C

Community members of Azathioprine (S_DC: 1.10)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

PADI4

ProteinNonearginine deiminase typeNone4

Predicted

0.1488

0.2778

0.4267

1.0567

P27695

APEX1

DNANone(apurinic or apyrimidinic site) endonuclease

Predicted

0.402

0.221

0.1217

0.7647

O95551

TTRAP

TyrosylNoneDNA phosphodiesterase 2

Predicted

0.2092

0.2569

0.6184

P84095

RHOG

RhoNonerelated GTPNonebinding protein RhoG

Predicted

0.3657

0.0096

0.3419

0.544

P61586

RHOA

Transforming protein RhoA

Predicted

0.3541

0.0689

1.3149

Q15669

RHOH

RhoNonerelated GTPNonebinding protein RhoH

Predicted

0.1226

0.0054

0.3003

0.3724

Q9NP90

RAB9B

RasNonerelated protein RabNone9B

Predicted

0.0875

0.0042

0.3017

0.3538

P61225

RAP2B

RasNonerelated protein RapNone2b

Predicted

0.4537

0.0041

0.2351

P10114

RAP2A

RasNonerelated protein RapNone2a

Predicted

0.232

0.0041

0.1242

P11233

RALA

RasNonerelated protein RalNoneA

Predicted

0.5681

0.0041

0.4789

0.7711

P51159

RAB27A

RasNonerelated protein RabNone27A

Predicted

0.3126

0.0041

0.1646

P62491

RAB11A

RasNonerelated protein RabNone11A

Predicted

0.2801

0.0042

0.2918

0.4402

O14966

RAB29

RasNonerelated protein RabNone7L1

Predicted

0.021

0.0043

0.0191

PharmaCoNets of Azathioprine (SPCN: 14.62 )

Azathioprine regulated-network (SDN: 13.30)

Community members of Azathioprine (SDC: 1.10)

PharmaCoNets of Azathioprine (S_PCN: 14.62 )

Azathioprine regulated-network (S_DN: 13.30)

Community members of Azathioprine (S_DC: 1.10)