PharmaCoNets of Axitinib (SPCN: 300.86 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Axitinibhsa00010Glycolysis / Gluconeogenesis2.50E-023P04075, P14550, P60174ALDOA, AKR1A1, TPI1More
Axitinibhsa00020Citrate cycle (TCA cycle)1.71E-034P50213, O75390, P40926, O14521IDH3A, CS, MDH2, SDHDMore
Axitinibhsa00030Pentose phosphate pathway8.90E-064P60891, P51854, P08237, P37837PRPS1, TKTL1, PFKM, TALDO1More
Axitinibhsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Axitinibhsa00051Fructose and mannose metabolism3.26E-022P60174, P04075TPI1, ALDOAMore
Axitinibhsa00052Galactose metabolism1.06E-032P06280, O43451GLA, MGAMMore
Axitinibhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Axitinibhsa00071Fatty acid degradation3.43E-044O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Axitinibhsa00190Oxidative phosphorylation7.71E-104Q16718, Q13488, P36542, O14521NDUFA5, TCIRG1, ATP5C1, SDHDMore
Axitinibhsa00220Arginine biosynthesis1.65E-063P15104, P05089, P49448GLUL, ARG1, GLUD2More
Axitinibhsa00230Purine metabolism1.81E-022P20839, Q02153IMPDH1, GUCY1B3More
Axitinibhsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Axitinibhsa00260Glycine, serine and threonine metabolism1.99E-021P22557ALAS2More
Axitinibhsa00310Lysine degradation2.59E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Axitinibhsa00340Histidine metabolism4.52E-021O95954FTCDMore
Axitinibhsa00350Tyrosine metabolism3.40E-021P28332ADH6More
Axitinibhsa00380Tryptophan metabolism1.33E-022P46952, P51648HAAO, ALDH3A2More
Axitinibhsa00500Starch and sucrose metabolism7.19E-094O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Axitinibhsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Axitinibhsa00512Mucin type O-glycan biosynthesis3.19E-033O95395, Q8N4A0, Q9NY28GCNT3, GALNT4, GALNT8More
Axitinibhsa00520Amino sugar and nucleotide sugar metabolism1.04E-033Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Axitinibhsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Axitinibhsa00531Glycosaminoglycan degradation4.51E-022P22304, P06865IDS, HEXAMore
Axitinibhsa00533Glycosaminoglycan biosynthesis - keratan sulfate6.96E-041Q9NY97B3GNT2More
Axitinibhsa00562Inositol phosphate metabolism1.91E-023P27987, Q13572, Q96PE3ITPKB, ITPK1, INPP4AMore
Axitinibhsa00564Glycerophospholipid metabolism2.53E-045P48651, Q9Y6K0, P35790, Q9Y259, P49619PTDSS1, CEPT1, CHKA, CHKB, DGKGMore
Axitinibhsa00565Ether lipid metabolism3.00E-031Q8N661TMEM86BMore
Axitinibhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Axitinibhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Axitinibhsa00600Sphingolipid metabolism2.65E-033Q9BX95, Q06136, P15289SGPP1, FVT1, ARSAMore
Axitinibhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Axitinibhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series8.72E-032P06865, O75752HEXA, B3GALNT1More
Axitinibhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Axitinibhsa00620Pyruvate metabolism2.03E-022P40926, P14550MDH2, AKR1A1More
Axitinibhsa00630Glyoxylate and dicarboxylate metabolism2.22E-072P40925, P15104MDH1, GLULMore
Axitinibhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Axitinibhsa00670One carbon pool by folate6.66E-054O95954, P00374, P04818, Q99707FTCD, DHFR, TYMS, MTRMore
Axitinibhsa00730Thiamine metabolism1.75E-073Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Axitinibhsa00740Riboflavin metabolism4.03E-021P24666ACP1More
Axitinibhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Axitinibhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Axitinibhsa00790Folate biosynthesis3.62E-021P00374DHFRMore
Axitinibhsa00830Retinol metabolism2.27E-035P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Axitinibhsa00860Porphyrin and chlorophyll metabolism8.96E-042P36551, P30043CPOX, BLVRBMore
Axitinibhsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Axitinibhsa00920Sulfur metabolism4.01E-041Q16762TSTMore
Axitinibhsa00970Aminoacyl-tRNA biosynthesis1.99E-084O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Axitinibhsa00980Metabolism of xenobiotics by cytochrome P4508.40E-043P78417, P28332, P11712GSTO1, ADH6, CYP2C9More
Axitinibhsa00982Drug metabolism - cytochrome P4508.40E-043P11712, P78417, P28332CYP2C9, GSTO1, ADH6More
Axitinibhsa00983Drug metabolism - other enzymes1.85E-053P04183, P32320, P05164TK1, CDA, MPOMore
Axitinibhsa01100Metabolic pathways2.82E-0455Q9NR34, Q9Y234, P35790, Q9Y259, P05089, Q16772, P15144, P30041, O14732, P32320, Q13956, Q02153, Q16774, P20839, P00918, P22748, P10768, P55809, P06280, Q16875, O43286, O43451, Q9Y6K0, P05186, P24666, P08237, P49619, P21399, O95954, Q9HCC0, P33121, Q02318, Q9UHK6, P51854, Q86VZ5, Q9BVK2, P15907, P57054, Q9UBX8, Q9UNP4, O96024, Q9BX95, P37837, P32321, P50213, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P35573, P06737, Q969G6, Q13029, Q9NVH6MAN1C1, LIPT1, CHKA, CHKB, ARG1, GSTA3, ANPEP, PRDX6, IMPA2, CDA, PDE6H, GUCY1B3, GUK1, IMPDH1, CA2, CA4, ESD, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, CEPT1, ALPL, ACP1, PFKM, DGKG, ACO1, FTCD, MCCC2, ACSL1, CYP27A1, AMACR, TKTL1, SGMS1, ALG8, ST6GAL1, PIGP, B4GALT6, ST3GAL5, B3GALT4, SGPP1, TALDO1, DCTD, IDH3A, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, AGL, PYGL, RFK, PRDM2, TMLHEMore
Axitinibhsa01200Carbon metabolism1.81E-026P51854, P08237, P37837, P50213, P21399, P10768TKTL1, PFKM, TALDO1, IDH3A, ACO1, ESDMore
Axitinibhsa012102-Oxocarboxylic acid metabolism6.75E-042P21399, P50213ACO1, IDH3AMore
Axitinibhsa01230Biosynthesis of amino acids7.89E-079P08237, P51854, P60891, Q99707, P21399, P50213, P05089, P15104, P37837PFKM, TKTL1, PRPS1, MTR, ACO1, IDH3A, ARG1, GLUL, TALDO1More
Axitinibhsa01240Biosynthesis of cofactors1.34E-034P13716, P36551, O60701, P14618ALAD, CPOX, UGDH, PKM2More
Axitinibhsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P04049RAF1More
Axitinibhsa01522Endocrine resistance3.41E-026P14780, P22694, P04049, Q9UM47, P10415, Q13323MMP9, PRKACB, RAF1, NOTCH3, BCL2, BIKMore
Axitinibhsa01523Antifolate resistance1.02E-055P41440, Q92820, P04818, P01375, P18054SLC19A1, GGH, TYMS, TNF, ALOX12More
Axitinibhsa01524Platinum drug resistance4.78E-021P31751AKT2More
Axitinibhsa02010ABC transporters1.66E-043P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Axitinibhsa03008Ribosome biogenesis in eukaryotes6.93E-046Q9NYH9, O14980, O60832, P78345, Q9BVP2, Q9GZY0UTP6, XPO1, DKC1, RPP38, GNL3, NXF2; NXF2BMore
Axitinibhsa03010Ribosome7.00E-1019P62753, P42677, P25398, P32969, P62917, P62829, P46776, Q07020, P62888, P62899, P62910, P18077, P61927, P61513, Q02878, P36578, P27635, P05386, P23396RPS6, RPS27, RPS12, RPL9, RPL8, RPL23, RPL27A, RPL18, RPL30, RPL31, RPL32, RPL35A, RPL37, RPL37A, RPL6, RPL4, RPL10, RPLP1, RPS3More
Axitinibhsa03013RNA transport5.79E-1931P62826, O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q9GZY0, Q9H307, Q7Z3B4, P35658, P63279, P68104, P47813, Q14152, P55884, O15371, O75822, P78345, P11940, Q13310, P20042, Q14240, Q9BZI7, P23588, Q9Y6A5, Q14232, Q06787, P51114, Q53GS7RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, NXF2; NXF2B, PNN, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, PABPC1, PABPC4, EIF2S2, EIF4A2, UPF3B, EIF4B, TACC3, EIF2B1, FMR1, FXR1, GLE1More
Axitinibhsa03015mRNA surveillance pathway1.21E-0310O43148, Q13310, Q13362, Q16537, P61326, Q15287, Q9UBU9, Q9GZY0, P52298, Q53GS7RNMT, PABPC4, PPP2R5C, PPP2R5E, MAGOH, RNPS1, NXF1, NXF2; NXF2B, NCBP2, GLE1More
Axitinibhsa03020RNA polymerase1.69E-106P30876, P24928, P62487, Q9GZM3, P52435, Q9Y535POLR2B, POLR2A, POLR2G, POLR2J2, POLR2J, POLR3HMore
Axitinibhsa03022Basal transcription factors2.97E-033P20226, O00268, Q15544TBP, TAF4, TAF11More
Axitinibhsa03040Spliceosome4.01E-1017Q14562, O43143, O60508, P08579, Q15427, P26368, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, SF3B4, U2AF2, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Axitinibhsa03050Proteasome4.83E-021P55036PSMD4More
Axitinibhsa03060Protein export9.30E-052P37108, Q15005SRP14, SPCS2More
Axitinibhsa03320PPAR signaling pathway1.84E-033O00767, Q13133, Q02318SCD, NR1H3, CYP27A1More
Axitinibhsa03430Mismatch repair4.38E-021P20585MSH3More
Axitinibhsa03450Non-homologous end-joining3.17E-032Q9NP87, P13010POLM, XRCC5More
Axitinibhsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Axitinibhsa04012ErbB signaling pathway7.21E-067P21860, P16333, Q13557, P19174, O14944, P01106, P04049ERBB3, NCK1, CAMK2D, PLCG1, EREG, MYC, RAF1More
Axitinibhsa04014Ras signaling pathway6.36E-0513P04049, P31751, P42338, P20827, Q9NRA1, P49767, Q13009, Q7LDG7, P0DP23, P62873, P63218, P50151, P19174RAF1, AKT2, PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, RASGRP2, CALM1, GNB1, GNG5, GNG10, PLCG1More
Axitinibhsa04015Rap1 signaling pathway2.07E-0619P04049, P09603, P20827, P49767, Q9GZP0, P06213, Q96FS4, P11215, P25116, Q8TEU7, Q13009, O00522, Q7LDG7, P42338, P31751, P0DP23, P08514, Q86WV1, P19174RAF1, CSF1, EFNA1, VEGFC, PDGFD, INSR, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, KRIT1, RASGRP2, PIK3CB, AKT2, CALM1, ITGA2B, SKAP1, PLCG1More
Axitinibhsa04020Calcium signaling pathway1.54E-0815P27987, Q96DU7, Q08828, P45880, Q16566, Q13557, P21860, P30679, O15399, P61073, P0DP23, P05141, P51828, P23634, P49767ITPKB, ITPKC, ADCY1, VDAC2, CAMK4, CAMK2D, ERBB3, GNA15, GRIN2D, CXCR4, CALM1, SLC25A5, ADCY7, ATP2B4, VEGFCMore
Axitinibhsa04022cGMP-PKG signaling pathway1.31E-0612P04049, Q99941, P18848, P23634, Q8WYR1, P31751, Q08828, P51828, P05141, P45880, P0DP24, P0DP23RAF1, CREBL1, ATF4, ATP2B4, PIK3R5, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2, CALM1More
Axitinibhsa04024cAMP signaling pathway8.43E-058Q08828, P51828, P42338, P31751, P0DP23, P04049, Q13370, Q13009ADCY1, ADCY7, PIK3CB, AKT2, CALM1, RAF1, PDE3B, TIAM1More
Axitinibhsa04060Cytokine-cytokine receptor interaction8.46E-0414P14784, P27930, P14778, P37173, P26842, Q06643, Q13651, P78552, P25024, Q9UBD3, P47992, P09341, P80075, P01730IL2RB, IL1R2, IL1R1, TGFBR2, CD27, LTB, IL10RA, IL13RA1, CXCR1, XCL2, XCL1, CXCL1, CCL8, CD4More
Axitinibhsa04061Viral protein interaction with cytokine and cytokine receptor1.20E-0713Q8NHW4, P09341, P19875, P25024, P02775, P25025, P61073, P47992, Q9UBD3, Q13651, P14784, P09603, P01375CCL4L2, CXCL1, CXCL2, CXCR1, PPBP, CXCR2, CXCR4, XCL1, XCL2, IL10RA, IL2RB, CSF1, TNFMore
Axitinibhsa04062Chemokine signaling pathway1.03E-0824P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q08881, Q7LDG7, Q13009, P14598, P22694, P42224, P04049, P25963, P49841, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ITK, RASGRP2, TIAM1, NCF1, PRKACB, STAT1, RAF1, NFKBIA, GSK3B, PIK3R5More
Axitinibhsa04064NF-kappa B signaling pathway2.14E-2231P10415, Q13489, P25963, P51617, Q12933, O00463, Q13546, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, P10145, P19784, P67870, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7BCL2, BIRC3, NFKBIA, IRAK1, TRAF2, TRAF5, RIPK1, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, IL8, CSNK2A2, CSNK2B, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLDMore
Axitinibhsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Axitinibhsa04070Phosphatidylinositol signaling system1.12E-0713P19174, P0DP23, Q14643, P42338, O14986, P23743, P49619, Q86XP1, Q16760, P48426, P27987, Q96DU7, P17252PLCG1, CALM1, ITPR1, PIK3CB, PIP5K1B, DGKA, DGKG, DGKH, DGKD, PIP4K2A, ITPKB, ITPKC, PRKCAMore
Axitinibhsa04071Sphingolipid signaling pathway4.51E-1112P04049, P17252, P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, Q16539, P04637, P10415, Q9UQC2RAF1, PRKCA, S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, MAPK14, TP53, BCL2, GAB2More
Axitinibhsa04072Phospholipase D signaling pathway2.64E-0514P04049, P31751, P42338, Q9UQC2, P43657, P25024, P25025, P19174, O14986, Q8WYR1, Q15438, Q08828, P51828, Q16760RAF1, AKT2, PIK3CB, GAB2, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PIK3R5, PSCD1, ADCY1, ADCY7, DGKDMore
Axitinibhsa04080Neuroactive ligand-receptor interaction1.42E-0511P08311, P48058, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, Q16581, P35318CTSG, GRIA4, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, C3AR1, ADMMore
Axitinibhsa04110Cell cycle2.03E-0910Q9UBD5, P06493, O60566, Q14683, O75293, P30304, P33981, P42773, P01106, Q13547ORC3, CDK1, BUB1B, SMC1A, GADD45B, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Axitinibhsa04114Oocyte meiosis3.23E-0612Q9Y6D9, P51812, Q02750, Q13557, P0DP23, P16298, Q17RY0, Q08828, P51828, P27348, Q13362, Q14738MAD1L1, RPS6KA3, MAP2K1, CAMK2D, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, YWHAQ, PPP2R5C, PPP2R5DMore
Axitinibhsa04115p53 signaling pathway3.32E-035P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Axitinibhsa04120Ubiquitin mediated proteolysis7.75E-058Q9UBT2, Q14145, Q13042, P62837, Q15751, O95071, Q14669, P0CG47SAE2, KEAP1, CDC16, UBE2D2, HERC1, UBR5, TRIP12, UBBMore
Axitinibhsa04122Sulfur relay system4.01E-041Q16762TSTMore
Axitinibhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Axitinibhsa04137Mitophagy - animal9.52E-032Q07817, P0CG47BCL2L1, UBBMore
Axitinibhsa04140Autophagy - animal1.20E-0413Q9Y4H2, P31751, P04049, Q7L523, Q9NQL2, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9IRS2, AKT2, RAF1, RRAGA, RRAGD, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Axitinibhsa04141Protein processing in endoplasmic reticulum5.96E-0513P18848, Q12933, P30101, Q15436, P60604, Q99941, O75460, P11142, Q9H3Z4, P07900, P08238, Q9H173, Q9UNL2ATF4, TRAF2, PDIA3, SEC23A, UBE2G2, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SIL1, SSR3More
Axitinibhsa04142Lysosome3.13E-0510Q99437, P25774, P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916, Q04900ATP6V0B, CTSS, HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2, CD164More
Axitinibhsa04144Endocytosis2.89E-038P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12More
Axitinibhsa04145Phagosome9.49E-1416O75015, P11215, P63261, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, Q99437, P05164, P78380, O60603, P35443, P13765, P25774FCGR3B, ITGAM, ACTG1, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, ATP6V0B, MPO, OLR1, TLR2, THBS4, HLA-DOB, CTSSMore
Axitinibhsa04146Peroxisome4.83E-024O96011, P56589, Q9UKG9, O75521PEX11B, PEX3, CROT, ECI2More
Axitinibhsa04150mTOR signaling pathway7.74E-034P04049, Q02750, Q9NQL2, P51812RAF1, MAP2K1, RRAGD, RPS6KA3More
Axitinibhsa04151PI3K-Akt signaling pathway3.68E-0734P62753, P42338, P43657, P25116, P01106, O43521, P27348, P09603, P20827, P49767, Q9GZP0, Q13362, P07900, P08238, Q8WYR1, P62873, P63218, P50151, P13612, P16144, O15335, Q16363, Q13751, P22105, O60603, P14784, P01568, Q99941, P18848, P10415, P17252, O00141, Q6ZUJ8, P30281RPS6, PIK3CB, P2RY5, F2R, MYC, BCL2L11, YWHAQ, CSF1, EFNA1, VEGFC, PDGFD, PPP2R5C, HSP90AA1, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGA4, ITGB4, CHAD, LAMA4, LAMB3, TNXB, TLR2, IL2RB, IFNA21, CREBL1, ATF4, BCL2, PRKCA, SGK, PIK3AP1, CCND3More
Axitinibhsa04210Apoptosis4.79E-0616Q13315, P10415, Q13489, O76075, P25963, P01375, Q9NR28, O75460, P24522, Q16548, Q13077, O43521, P43234, P18848, Q14643, P04049ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, DIABLO, ERN1, GADD45A, BCL2A1, TRAF1, BCL2L11, CTSO, ATF4, ITPR1, RAF1More
Axitinibhsa04211Longevity regulating pathway9.34E-047Q12778, P31751, Q08828, P51828, P18848, Q9UEF7, Q96KQ7FOXO1, AKT2, ADCY1, ADCY7, ATF4, KL, EHMT2More
Axitinibhsa04213Longevity regulating pathway - multiple species3.08E-058P31751, P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Axitinibhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Axitinibhsa04217Necroptosis8.10E-1323P01375, Q12933, P01568, P48023, Q13489, Q9NQC7, Q13546, P42224, Q14765, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, P10415, Q13557, Q9H444, O43633, Q08752TNF, TRAF2, IFNA21, FASLG, BIRC3, CYLD, RIPK1, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CAMK2D, CHMP4B, CHMP2A, PPIDMore
Axitinibhsa04218Cellular senescence3.00E-047P01106, P31751, P04049, O75293, P30304, P06493, P0DP23MYC, AKT2, RAF1, GADD45B, CDC25A, CDK1, CALM1More
Axitinibhsa04260Cardiac muscle contraction4.76E-035P09493, P67936, P13073, P12074, P14927TPM1, TPM4, COX4I1, COX6A1, UQCRBMore
Axitinibhsa04261Adrenergic signaling in cardiomyocytes4.90E-0916P09493, P67936, Q08828, P51828, Q8WYR1, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, P0DP24, Q13557, P17252, P10415, P23634TPM1, TPM4, ADCY1, ADCY7, PIK3R5, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CALM2, CAMK2D, PRKCA, BCL2, ATP2B4More
Axitinibhsa04270Vascular smooth muscle contraction1.23E-048P0DP24, P0DP23, P04049, Q08828, P51828, P35579, P35749, P35318CALM2, CALM1, RAF1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Axitinibhsa04330Notch signaling pathway2.52E-056Q92542, P49768, Q92830, P78504, P46531, Q9UM47NCSTN, PSEN1, KAT2A, JAG1, NOTCH1, NOTCH3More
Axitinibhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Axitinibhsa04360Axon guidance9.70E-048P16333, P20827, O95631, P42338, P07332, P23528, P04049, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, RAF1, PLCG1More
Axitinibhsa04370VEGF signaling pathway1.47E-065P16298, P31751, Q05397, Q02750, P04049PPP3CB, AKT2, PTK2, MAP2K1, RAF1More
Axitinibhsa04371Apelin signaling pathway1.97E-0815P62873, P63218, P50151, Q8WYR1, P31751, P04049, Q08828, P51828, Q13370, Q14814, Q14344, Q13485, P84022, Q16566, P0DP23GNB1, GNG5, GNG10, PIK3R5, AKT2, RAF1, ADCY1, ADCY7, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, CAMK4, CALM1More
Axitinibhsa04380Osteoclast differentiation3.07E-0714Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Axitinibhsa04390Hippo signaling pathway3.80E-058P63261, P84022, Q13485, O15105, P04628, Q9UJU2, O43623, Q13489ACTG1, SMAD3, SMAD4, SMAD7, WNT1, LEF1, SNAI2, BIRC3More
Axitinibhsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Axitinibhsa04510Focal adhesion3.48E-021P04049RAF1More
Axitinibhsa04512ECM-receptor interaction1.62E-034P07359, P26012, P08514, P16070GP1BA, ITGB8, ITGA2B, CD44More
Axitinibhsa04514Cell adhesion molecules8.19E-033P16109, P56750, O00501SELP, CLDN17, CLDN5More
Axitinibhsa04530Tight junction3.28E-078Q8TEU7, P63261, P16989, P56750, O00501, Q92974, Q14247, P24844RAPGEF6, ACTG1, CSDA, CLDN17, CLDN5, ARHGEF2, CTTN, MYL9More
Axitinibhsa04540Gap junction1.17E-057P17252, Q13509, P68371, Q71U36, P04049, Q9NRA1, Q14643PRKCA, TUBB3, TUBB2C, TUBA1A, RAF1, PDGFC, ITPR1More
Axitinibhsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P04049RAF1More
Axitinibhsa04610Complement and coagulation cascades2.64E-106P25116, P09871, P00734, P0C0L4, P05107, P21730F2R, C1S, F2, C4A, ITGB2, C5AR1More
Axitinibhsa04611Platelet activation5.18E-055P25116, P08514, Q15746, Q8WYR1, P07359F2R, ITGA2B, MYLK, PIK3R5, GP1BAMore
Axitinibhsa04612Antigen processing and presentation4.73E-0810P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, TNFMore
Axitinibhsa04613Neutrophil extracellular trap formation1.24E-1332P19174, P17252, P04049, P16109, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P63261, P07359, O43315, Q16539PLCG1, PRKCA, RAF1, SELP, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, ACTG1, GP1BA, AQP9, MAPK14More
Axitinibhsa04614Renin-angiotensin system8.01E-034P15144, P10619, P08311, O75787ANPEP, CTSA, CTSG, ATP6AP2More
Axitinibhsa04620Toll-like receptor signaling pathway6.42E-055Q13546, P01568, P01584, P31751, Q8NHW4RIPK1, IFNA21, IL1B, AKT2, CCL4L2More
Axitinibhsa04621NOD-like receptor signaling pathway4.78E-0720P01584, P07900, Q16539, Q14643, P01568, P21796, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q13546, P29728, Q05823, P01375, P09341, P49913, P12838IL1B, HSP90AA1, MAPK14, ITPR1, IFNA21, VDAC1, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RIPK1, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA4More
Axitinibhsa04622RIG-I-like receptor signaling pathway5.55E-055P01568, Q9NQC7, Q13546, Q12933, P10145IFNA21, CYLD, RIPK1, TRAF2, IL8More
Axitinibhsa04623Cytosolic DNA-sensing pathway9.66E-146P01584, P01568, Q13546, P25963, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, NFKBIA, POLR3H, CCL4L2More
Axitinibhsa04625C-type lectin receptor signaling pathway1.30E-0712Q9ULY5, P04049, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539CLEC4E, RAF1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14More
Axitinibhsa04630JAK-STAT signaling pathway7.22E-047P01106, P31751, P42224, P23458, P14784, Q13651, P04049MYC, AKT2, STAT1, JAK1, IL2RB, IL10RA, RAF1More
Axitinibhsa04640Hematopoietic cell lineage1.47E-1318P13612, P21926, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P09603, P01584ITGA4, CD9, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, CSF1, IL1BMore
Axitinibhsa04650Natural killer cell mediated cytotoxicity1.39E-1818P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, P04049, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Axitinibhsa04657IL-17 signaling pathway2.07E-0710P07900, O00463, Q12933, Q16539, P49841, P09341, P14780, P80188, P01375, P01584HSP90AA1, TRAF5, TRAF2, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Axitinibhsa04658Th1 and Th2 cell differentiation3.51E-3216Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Axitinibhsa04659Th17 cell differentiation6.94E-2622P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, P40189, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, IL6ST, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Axitinibhsa04660T cell receptor signaling pathway6.83E-2220P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P16333, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Axitinibhsa04662B cell receptor signaling pathway3.51E-078P31751, P42338, P60033, P13164, P07948, P21854, Q8N149, P04049AKT2, PIK3CB, CD81, IFITM1, LYN, CD72, LILRA2, RAF1More
Axitinibhsa04664Fc epsilon RI signaling pathway2.46E-0810P01375, P31751, P04141, Q16539, P42338, Q9UQC2, P07948, P19174, P04049, P09917TNF, AKT2, CSF2, MAPK14, PIK3CB, GAB2, LYN, PLCG1, RAF1, ALOX5More
Axitinibhsa04666Fc gamma R-mediated phagocytosis1.29E-059O75015, P42338, P04049, P23528, P49006, P06396, O14494, P14598, P17252FCGR3B, PIK3CB, RAF1, CFL1, MARCKSL1, GSN, PLPP1, NCF1, PRKCAMore
Axitinibhsa04668TNF signaling pathway1.54E-0614P01375, Q12933, O00463, Q13489, Q16539, P25963, Q99941, P18848, P01584, P20749, Q13077, P14780, P20333, O95429TNF, TRAF2, TRAF5, BIRC3, MAPK14, NFKBIA, CREBL1, ATF4, IL1B, BCL3, TRAF1, MMP9, TNFRSF1B, BAG4More
Axitinibhsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Axitinibhsa04672Intestinal immune network for IgA production1.24E-043P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Axitinibhsa04710Circadian rhythm4.40E-021O15516CLOCKMore
Axitinibhsa04713Circadian entrainment1.75E-048P0DP23, P17252, P62873, P63218, P50151, Q14643, Q08828, P51828CALM1, PRKCA, GNB1, GNG5, GNG10, ITPR1, ADCY1, ADCY7More
Axitinibhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Axitinibhsa04720Long-term potentiation8.62E-059P17252, P16298, P0DP23, P51812, P18848, Q08828, Q02750, P04049, Q14643PRKCA, PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1, RAF1, ITPR1More
Axitinibhsa04721Synaptic vesicle cycle9.45E-042Q13488, P31645TCIRG1, SLC6A4More
Axitinibhsa04722Neurotrophin signaling pathway2.01E-046P31751, P04049, P49841, O43524, P48023, P0DP23AKT2, RAF1, GSK3B, FOXO3, FASLG, CALM1More
Axitinibhsa04723Retrograde endocannabinoid signaling1.26E-048Q14643, P17252, P62873, P63218, P50151, P22694, Q16539, Q16718ITPR1, PRKCA, GNB1, GNG5, GNG10, PRKACB, MAPK14, NDUFA5More
Axitinibhsa04724Glutamatergic synapse2.49E-056O15399, P62873, P63218, P50151, P15104, Q9NSB8GRIN2D, GNB1, GNG5, GNG10, GLUL, HOMER2More
Axitinibhsa04725Cholinergic synapse1.04E-0613Q08828, P51828, P22694, Q14643, P17252, P62873, P63218, P50151, P18848, Q13557, P42338, P31751, P10415ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, GNB1, GNG5, GNG10, ATF4, CAMK2D, PIK3CB, AKT2, BCL2More
Axitinibhsa04726Serotonergic synapse5.74E-035P62873, P63218, P50151, P09917, P04049GNB1, GNG5, GNG10, ALOX5, RAF1More
Axitinibhsa04727GABAergic synapse1.66E-044P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Axitinibhsa04728Dopaminergic synapse9.50E-0610Q14643, P17252, P62873, P31751, Q99941, P18848, Q13557, Q13362, Q14738, P0DP23ITPR1, PRKCA, GNB1, AKT2, CREBL1, ATF4, CAMK2D, PPP2R5C, PPP2R5D, CALM1More
Axitinibhsa04730Long-term depression1.35E-033Q14344, P04049, P07948GNA13, RAF1, LYNMore
Axitinibhsa04740Olfactory transduction9.46E-042Q9H255, P0DP23OR51E2, CALM1More
Axitinibhsa04742Taste transduction1.01E-021P30939HTR1FMore
Axitinibhsa04744Phototransduction2.24E-062P62873, P0DP23GNB1, CALM1More
Axitinibhsa04750Inflammatory mediator regulation of TRP channels8.54E-1014P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1More
Axitinibhsa04810Regulation of actin cytoskeleton7.86E-034Q15746, P04049, P08514, P25116MYLK, RAF1, ITGA2B, F2RMore
Axitinibhsa04910Insulin signaling pathway2.43E-056P0DP23, P22694, P06737, P04049, P31751, P49841CALM1, PRKACB, PYGL, RAF1, AKT2, GSK3BMore
Axitinibhsa04911Insulin secretion2.03E-075Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Axitinibhsa04912GnRH signaling pathway4.74E-0712P17252, Q08828, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP23, P0DP24, P22694, P04049PRKCA, ADCY1, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM1, CALM2, PRKACB, RAF1More
Axitinibhsa04913Ovarian steroidogenesis2.52E-021P06213INSRMore
Axitinibhsa04914Progesterone-mediated oocyte maturation7.73E-058Q17RY0, P42338, Q13370, Q9Y6D9, P08238, P51812, Q02750, P04049CPEB4, PIK3CB, PDE3B, MAD1L1, HSP90AB1, RPS6KA3, MAP2K1, RAF1More
Axitinibhsa04915Estrogen signaling pathway2.07E-0716P14780, P22694, P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, Q14643, P0DP24, P0DP23, Q15788, P10415MMP9, PRKACB, RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, ITPR1, CALM2, CALM1, NCOA1, BCL2More
Axitinibhsa04916Melanogenesis3.49E-058Q13557, P0DP23, Q9UJU2, Q08828, P51828, P17252, P04628, P04049CAMK2D, CALM1, LEF1, ADCY1, ADCY7, PRKCA, WNT1, RAF1More
Axitinibhsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Axitinibhsa04918Thyroid hormone synthesis3.59E-035P22694, Q99941, P18848, Q14643, P02768PRKACB, CREBL1, ATF4, ITPR1, ALBMore
Axitinibhsa04919Thyroid hormone signaling pathway3.93E-059P49841, P19174, P04049, P42224, P22694, Q13547, O60244, Q9NVC6, P01106GSK3B, PLCG1, RAF1, STAT1, PRKACB, HDAC1, MED14, MED17, MYCMore
Axitinibhsa04920Adipocytokine signaling pathway1.22E-025P25963, P33121, Q04759, P31751, P01375NFKBIA, ACSL1, PRKCQ, AKT2, TNFMore
Axitinibhsa04921Oxytocin signaling pathway5.68E-035P0DP24, P51828, P04049, Q96RR4, Q8WYR1CALM2, ADCY7, RAF1, CAMKK2, PIK3R5More
Axitinibhsa04922Glucagon signaling pathway3.10E-047P14618, P06737, Q12778, P31751, Q13370, P0DP23, Q14643PKM2, PYGL, FOXO1, AKT2, PDE3B, CALM1, ITPR1More
Axitinibhsa04923Regulation of lipolysis in adipocytes9.57E-067Q08828, P51828, P07550, P06213, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, INSR, PIK3CB, IRS2, AKT2More
Axitinibhsa04924Renin secretion2.13E-054P07550, Q14643, Q13370, P0DP23ADRB2, ITPR1, PDE3B, CALM1More
Axitinibhsa04925Aldosterone synthesis and secretion3.48E-077Q99941, P18848, Q08828, P51828, P0DP23, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM1, CAMK2D, ATP2B4More
Axitinibhsa04926Relaxin signaling pathway1.26E-0410P31751, P42338, P63218, P50151, P18848, P49767, Q08828, P51828, P04049, P49407AKT2, PIK3CB, GNG5, GNG10, ATF4, VEGFC, ADCY1, ADCY7, RAF1, ARRB1More
Axitinibhsa04927Cortisol synthesis and secretion5.81E-066Q14643, Q99941, P18848, Q08828, P51828, P22694ITPR1, CREBL1, ATF4, ADCY1, ADCY7, PRKACBMore
Axitinibhsa04928Parathyroid hormone synthesis, secretion and action1.25E-037Q14643, P22694, P23771, P04049, P17252, P18848, P10415ITPR1, PRKACB, GATA3, RAF1, PRKCA, ATF4, BCL2More
Axitinibhsa04929GnRH secretion2.28E-044P42338, P31751, P49407, P04049PIK3CB, AKT2, ARRB1, RAF1More
Axitinibhsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Axitinibhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Axitinibhsa04932Non-alcoholic fatty liver disease9.44E-1214P31751, P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, Q16718, O95298, O14521AKT2, TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, SDHDMore
Axitinibhsa04933AGE-RAGE signaling pathway in diabetic complications8.03E-059P84022, Q13485, P42224, P10415, P42338, Q12778, P49767, P17252, P19174SMAD3, SMAD4, STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1More
Axitinibhsa04934Cushing syndrome8.02E-086Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Axitinibhsa04935Growth hormone synthesis, secretion and action5.00E-035Q08828, P51828, P04049, P18848, P31751ADCY1, ADCY7, RAF1, ATF4, AKT2More
Axitinibhsa04940Type I diabetes mellitus2.61E-034P10747, P48023, P13765, P01375CD28, FASLG, HLA-DOB, TNFMore
Axitinibhsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Axitinibhsa04960Aldosterone-regulated sodium reabsorption7.59E-032O00141, P06213SGK, INSRMore
Axitinibhsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Axitinibhsa04964Proximal tubule bicarbonate reclamation2.17E-031P00918CA2More
Axitinibhsa04966Collecting duct acid secretion1.26E-043Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Axitinibhsa04970Salivary secretion8.18E-057Q08828, P51828, P22694, Q14643, P17252, P0DP23, P49913ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, CALM1, CAMPMore
Axitinibhsa04971Gastric acid secretion3.12E-075Q08828, P51828, P15311, P0DP23, Q13557ADCY1, ADCY7, VIL2, CALM1, CAMK2DMore
Axitinibhsa04972Pancreatic secretion1.99E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Axitinibhsa04973Carbohydrate digestion and absorption4.61E-033O43451, P42338, P31751MGAM, PIK3CB, AKT2More
Axitinibhsa04975Fat digestion and absorption9.50E-041O14494PLPP1More
Axitinibhsa04976Bile secretion7.42E-066O43315, Q08828, P51828, P22694, P08183, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Axitinibhsa05010Alzheimer disease4.02E-0925Q92542, O15239, Q16718, O95298, O14521, P05496, P13073, P12074, Q14643, Q00535, O75460, P0DP23, P0DP24, P01584, O95197, P18848, Q13509, P68371, O15169, P67870, P31751, P05141, P45880, Q08752, P28070NCSTN, NDUFA1, NDUFA5, NDUFC2, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, CDK5, ERN1, CALM1, CALM2, IL1B, RTN3, ATF4, TUBB3, TUBB2C, AXIN1, CSNK2B, AKT2, SLC25A5, VDAC2, PPID, PSMB4More
Axitinibhsa05012Parkinson disease1.90E-0621O15239, Q16718, O14521, P13073, P12074, P05496, P05141, P12236, P60604, O75460, P18848, P28070, P43686, Q14643, P19174, P0DP23, P0DP24, Q13557, Q71U36, Q13509, P68371NDUFA1, NDUFA5, SDHD, COX4I1, COX6A1, ATP5G1, SLC25A5, SLC25A6, UBE2G2, ERN1, ATF4, PSMB4, PSMC4, ITPR1, PLCG1, CALM1, CALM2, CAMK2D, TUBA1A, TUBB3, TUBB2CMore
Axitinibhsa05014Amyotrophic lateral sclerosis2.72E-0210P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7More
Axitinibhsa05016Huntington disease9.86E-0815O15239, O95298, P13073, P12074, P05496, Q9GZM3, P24928, P30876, P62487, P52435, P05141, Q9NYC9, O75460, P28070, O00232NDUFA1, NDUFC2, COX4I1, COX6A1, ATP5G1, POLR2J2, POLR2A, POLR2B, POLR2G, POLR2J, SLC25A5, DNAH9, ERN1, PSMB4, PSMD12More
Axitinibhsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Axitinibhsa05020Prion disease7.13E-0824P01584, P46531, P11142, O15239, Q16718, O14521, P05496, P12074, Q92736, Q14643, P18848, P05141, P12236, P45880, P28070, P43686, O60282, Q13509, P68371, P49841, Q99941, P14598, Q15080, Q16539IL1B, NOTCH1, HSPA8, NDUFA1, NDUFA5, SDHD, ATP5G1, COX6A1, RYR2, ITPR1, ATF4, SLC25A5, SLC25A6, VDAC2, PSMB4, PSMC4, KIF5C, TUBB3, TUBB2C, GSK3B, CREBL1, NCF1, NCF4, MAPK14More
Axitinibhsa05022Pathways of neurodegeneration - multiple diseases1.25E-0829Q14643, Q13509, P68371, P49841, P10415, O15239, Q16718, O95298, O14521, P13073, P12074, P05496, Q06055, Q8TEV9, O75460, P18848, Q13561, P05141, P17252, P20333, Q16539, Q00535, P01584, Q08752, O15020, P0DP23, P0DP24, Q13557, P28070ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA1, NDUFA5, NDUFC2, SDHD, COX4I1, COX6A1, ATP5G1, ATP5G2, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, PRKCA, TNFRSF1B, MAPK14, CDK5, IL1B, PPID, SPTBN2, CALM1, CALM2, CAMK2D, PSMB4More
Axitinibhsa05030Cocaine addiction5.99E-033Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Axitinibhsa05031Amphetamine addiction7.53E-044P0DP23, Q13557, Q99941, P18848CALM1, CAMK2D, CREBL1, ATF4More
Axitinibhsa05032Morphine addiction7.26E-046P62873, P63218, P50151, Q13370, Q07343, P43250GNB1, GNG5, GNG10, PDE3B, PDE4B, GRK6More
Axitinibhsa05033Nicotine addiction2.54E-022P28472, O15399GABRB3, GRIN2DMore
Axitinibhsa05034Alcoholism5.69E-069Q13547, P62879, P04049, Q9BTM1, Q93077, P62807, Q16778, O60814, P68431HDAC1, GNB2, RAF1, H2AFJ, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Axitinibhsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Axitinibhsa05110Vibrio cholerae infection4.78E-021Q99437ATP6V0BMore
Axitinibhsa05120Epithelial cell signaling in Helicobacter pylori infection8.42E-089Q16539, P25963, Q13488, P09341, P19875, P19174, P25024, P25025, P07948MAPK14, NFKBIA, TCIRG1, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYNMore
Axitinibhsa05130Pathogenic Escherichia coli infection1.24E-0310Q71U36, Q14247, P56750, O00501, P16333, Q13509, P68371, P25116, Q14344, P25963TUBA1A, CTTN, CLDN17, CLDN5, NCK1, TUBB3, TUBB2C, F2R, GNA13, NFKBIAMore
Axitinibhsa05131Shigellosis3.31E-0421P01375, P25963, O00463, P14778, Q16539, P68431, Q04759, Q9UDY8, P61088, Q9NQL2, Q9H1Y0, Q14247, P12814, Q14643, Q12778, P49841, Q13315, P10415, P21796, Q08752, Q96A32TNF, NFKBIA, TRAF5, IL1R1, MAPK14, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCQ, MALT1, UBE2N, RRAGD, ATG5, CTTN, ACTN1, ITPR1, FOXO1, GSK3B, ATM, BCL2, VDAC1, PPID, MYLPFMore
Axitinibhsa05132Salmonella infection6.24E-1121P51617, P25963, P01375, P08238, P04049, Q9UJU2, P63261, O00471, Q13546, Q13489, P10415, O75369, Q96A32, O60603, Q9BQS8, Q13561, O60282, Q71U36, Q13509, P68371, P49754IRAK1, NFKBIA, TNF, HSP90AB1, RAF1, LEF1, ACTG1, EXOC5, RIPK1, BIRC3, BCL2, FLNB, MYLPF, TLR2, FYCO1, DCTN2, KIF5C, TUBA1A, TUBB3, TUBB2C, VPS41More
Axitinibhsa05133Pertussis2.57E-086P05107, P0DP23, P10145, P09871, P0C0L4, Q02556ITGB2, CALM1, IL8, C1S, C4A, IRF8More
Axitinibhsa05134Legionellosis1.05E-048P01584, P25963, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875IL1B, NFKBIA, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2More
Axitinibhsa05135Yersinia infection1.52E-026P13612, P06239, Q16539, P49841, P01730, P01732ITGA4, LCK, MAPK14, GSK3B, CD4, CD8AMore
Axitinibhsa05140Leishmaniasis1.89E-1316P13612, O75015, P14598, P11215, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, ITGAM, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4More
Axitinibhsa05143African trypanosomiasis5.12E-064P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Axitinibhsa05144Malaria1.21E-0810P60033, P69905, P68871, O60603, P01375, P05107, P35443, P01584, P10145, P26718CD81, HBA2, HBB, TLR2, TNF, ITGB2, THBS4, IL1B, IL8, KLRK1More
Axitinibhsa05145Toxoplasmosis4.00E-0614P51617, P25963, P01375, P10415, Q13489, P23458, P42224, P28068, P13765, Q8WYR1, Q16787, P0DMV8, O60603, P29965IRAK1, NFKBIA, TNF, BCL2, BIRC3, JAK1, STAT1, HLA-DMB, HLA-DOB, PIK3R5, LAMA3, HSPA1A, TLR2, CD40LGMore
Axitinibhsa05146Amoebiasis2.74E-1313P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Axitinibhsa05150Staphylococcus aureus infection4.74E-0813P0C0L4, P21730, P21462, O75015, P13765, Q16581, P13646, Q14532, P05107, P59665, P59666, P12838, P49913C4A, C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT13, KRT32, ITGB2, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Axitinibhsa05152Tuberculosis8.45E-0918P04049, Q13488, Q99437, P0DP23, O75015, P42224, P48382, O60603, P01375, P31751, P10415, P13765, P25774, P01568, P49913, Q9UDY8, Q16539, P51617RAF1, TCIRG1, ATP6V0B, CALM1, FCGR3B, STAT1, RFX5, TLR2, TNF, AKT2, BCL2, HLA-DOB, CTSS, IFNA21, CAMP, MALT1, MAPK14, IRAK1More
Axitinibhsa05160Hepatitis C1.98E-048P60033, O00501, P29728, P04049, P49841, P01375, P48023, P01106CD81, CLDN5, OAS2, RAF1, GSK3B, TNF, FASLG, MYCMore
Axitinibhsa05161Hepatitis B2.46E-0514P17252, P04049, P14780, Q99941, P18848, P25963, Q13485, P01375, P10415, P27348, P84022, P51617, O60603, Q14765PRKCA, RAF1, MMP9, CREBL1, ATF4, NFKBIA, SMAD4, TNF, BCL2, YWHAQ, SMAD3, IRAK1, TLR2, STAT4More
Axitinibhsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Axitinibhsa05163Human cytomegalovirus infection3.84E-1227P31751, P04049, P01375, P25963, P62873, P63218, P50151, Q14643, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P22694, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, P18848, P04637, O00463, P30101, P01568AKT2, RAF1, TNF, NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, PRKACB, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5, PDIA3, IFNA21More
Axitinibhsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Axitinibhsa05165Human papillomavirus infection4.48E-0310P16144, Q16787, Q05086, P01568, P42224, Q13488, Q02930, Q13362, Q12778, Q13315ITGB4, LAMA3, UBE3A, IFNA21, STAT1, TCIRG1, CREB5, PPP2R5C, FOXO1, ATMMore
Axitinibhsa05166Human T-cell leukemia virus 1 infection5.15E-0310P23458, P05141, P62826, Q08828, P51828, P18848, Q02930, P31751, P28068, Q13315JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, CREB5, AKT2, HLA-DMB, ATMMore
Axitinibhsa05167Kaposi sarcoma-associated herpesvirus infection3.54E-0818P01568, P31751, P42224, P25963, P62873, P62879, P63218, P50151, P19174, P16298, Q14643, P04049, Q02750, P07948, P04141, P0DP23, P0CG47, Q9UJU2IFNA21, AKT2, STAT1, NFKBIA, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, ITPR1, RAF1, MAP2K1, LYN, CSF2, CALM1, UBB, LEF1More
Axitinibhsa05168Herpes simplex virus 1 infection4.15E-0619P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q9Y2A4, Q13398, P51522, Q9HCX3, P17038, Q03923, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF304, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212More
Axitinibhsa05169Epstein-Barr virus infection1.35E-0616P13765, P01106, Q13547, O00463, Q16539, P42338, P07948, Q13761, P24522, O75293, P42224, P01375, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, STAT1, TNF, OAS2, CD3E, CD3G, CD247More
Axitinibhsa05170Human immunodeficiency virus 1 infection1.24E-1128P31751, P04049, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, P01375, Q05397, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P19174, P23528, P10415, Q13619, Q93034, Q9Y6Q5, P20333AKT2, RAF1, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, TNF, PTK2, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, CFL1, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1BMore
Axitinibhsa05171Coronavirus disease - COVID-192.69E-0920P01584, P23396, P62753, P25398, P42677, P36578, Q02878, P62917, P32969, P27635, Q07020, P62888, P46776, P62899, P62910, P18077, P61927, P61513, P05386, P62829IL1B, RPS3, RPS6, RPS12, RPS27, RPL4, RPL6, RPL8, RPL9, RPL10, RPL18, RPL30, RPL27A, RPL31, RPL32, RPL35A, RPL37, RPL37A, RPLP1, RPL23More
Axitinibhsa05200Pathways in cancer7.36E-0834Q13751, P17301, P42338, P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, P20585, Q13547, P14923, P30281, P10415, Q13489, P49767, Q12778, P31751, P43657, P25116, P62873, P62879, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P01568, P14784, P40189LAMB3, ITGA2, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, MSH3, HDAC1, JUP, CCND3, BCL2, BIRC3, VEGFC, FOXO1, AKT2, P2RY5, F2R, GNB1, GNB2, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IFNA21, IL2RB, IL6STMore
Axitinibhsa05202Transcriptional misregulation in cancer3.69E-1424Q12778, Q15532, Q13315, P41732, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P04637, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, TSPAN7, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, TP53, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Axitinibhsa05203Viral carcinogenesis1.45E-0514Q12933, Q99941, P18848, P23458, P27348, Q7KZF4, Q13547, Q15283, P12814, P61978, P06493, P62807, Q16778, O60814TRAF2, CREBL1, ATF4, JAK1, YWHAQ, SND1, HDAC1, RASA2, ACTN1, HNRPK, CDK1, HIST1H2BC, HIST2H2BE, H2BC12More
Axitinibhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Axitinibhsa05205Proteoglycans in cancer4.37E-0413Q13009, Q12955, Q14643, O75369, P63261, P04049, P04637, P14780, P17252, O60603, P04628, Q13635, P08962TIAM1, ANK3, ITPR1, FLNB, ACTG1, RAF1, TP53, MMP9, PRKCA, TLR2, WNT1, PTCH1, CD63More
Axitinibhsa05206MicroRNAs in cancer6.19E-047P15311, P21860, P61978, P46531, P63279, P22105, P04049VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB, RAF1More
Axitinibhsa05210Colorectal cancer1.46E-046Q9UKG1, P84022, Q13485, P04049, P10415, P37173APPL1, SMAD3, SMAD4, RAF1, BCL2, TGFBR2More
Axitinibhsa05211Renal cell carcinoma1.29E-032P31751, P04049AKT2, RAF1More
Axitinibhsa05212Pancreatic cancer1.28E-079P42338, P31751, P04049, Q15311, P23458, P42224, P84022, Q13485, O75293PIK3CB, AKT2, RAF1, RALBP1, JAK1, STAT1, SMAD3, SMAD4, GADD45BMore
Axitinibhsa05213Endometrial cancer4.41E-044O15169, P31751, Q02750, P04049AXIN1, AKT2, MAP2K1, RAF1More
Axitinibhsa05214Glioma7.01E-066P0DP23, P04049, P42338, P31751, P19174, O75293CALM1, RAF1, PIK3CB, AKT2, PLCG1, GADD45BMore
Axitinibhsa05215Prostate cancer1.33E-021P04049RAF1More
Axitinibhsa05216Thyroid cancer3.35E-035P01106, Q9UJU2, P04637, P24522, O75293MYC, LEF1, TP53, GADD45A, GADD45BMore
Axitinibhsa05217Basal cell carcinoma3.03E-046Q13635, P04628, P49841, Q9UJU2, P04637, P24522PTCH1, WNT1, GSK3B, LEF1, TP53, GADD45AMore
Axitinibhsa05218Melanoma4.47E-042P31751, P04049AKT2, RAF1More
Axitinibhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Axitinibhsa05220Chronic myeloid leukemia2.22E-058Q13547, Q13485, P25963, P84022, P31751, P42338, P04049, O75293HDAC1, SMAD4, NFKBIA, SMAD3, AKT2, PIK3CB, RAF1, GADD45BMore
Axitinibhsa05221Acute myeloid leukemia8.16E-042P31751, P04049AKT2, RAF1More
Axitinibhsa05222Small cell lung cancer3.73E-047P31751, Q13489, P10415, P25963, Q13077, O00463, P24522AKT2, BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Axitinibhsa05223Non-small cell lung cancer7.92E-066P31751, P19174, P10826, P04049, Q9HC35, O75293AKT2, PLCG1, RARB, RAF1, EML4, GADD45BMore
Axitinibhsa05224Breast cancer1.24E-025P04049, P49841, Q92837, P04637, P24522RAF1, GSK3B, FRAT1, TP53, GADD45AMore
Axitinibhsa05225Hepatocellular carcinoma1.33E-021P04049RAF1More
Axitinibhsa05226Gastric cancer2.61E-057P04049, Q02750, P31751, O15169, P84022, Q13485, P10415RAF1, MAP2K1, AKT2, AXIN1, SMAD3, SMAD4, BCL2More
Axitinibhsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Axitinibhsa05231Choline metabolism in cancer1.69E-077P04049, P31751, Q9Y259, P19174, P49619, Q16760, O14986RAF1, AKT2, CHKB, PLCG1, DGKG, DGKD, PIP5K1BMore
Axitinibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer7.71E-1715P42338, O95267, P19174, P07766, P20963, P09693, P06239, P04049, P23458, P42224, O60603, Q04759, Q16539, Q9HC35, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, JAK1, STAT1, TLR2, PRKCQ, MAPK14, EML4, CD4More
Axitinibhsa05310Asthma1.35E-073P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Axitinibhsa05320Autoimmune thyroid disease2.92E-054P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Axitinibhsa05321Inflammatory bowel disease2.52E-148O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21RMore
Axitinibhsa05322Systemic lupus erythematosus3.06E-0916O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P12814, P05455FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1, SSBMore
Axitinibhsa05323Rheumatoid arthritis1.22E-035P13765, Q13488, P10747, P09341, O60603HLA-DOB, TCIRG1, CD28, CXCL1, TLR2More
Axitinibhsa05330Allograft rejection1.04E-035P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Axitinibhsa05332Graft-versus-host disease1.35E-126P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Axitinibhsa05340Primary immunodeficiency2.33E-065P01730, P01732, P11912, P07766, P06239CD4, CD8A, CD79A, CD3E, LCKMore
Axitinibhsa05410Hypertrophic cardiomyopathy2.03E-022P26012, P09493ITGB8, TPM1More
Axitinibhsa05412Arrhythmogenic right ventricular cardiomyopathy2.17E-031P54284CACNB3More
Axitinibhsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Axitinibhsa05415Diabetic cardiomyopathy1.01E-0510P17252, P30405, P14598, Q15080, Q16718, O14521, Q16539, P49841, P37173, P04406PRKCA, PPIF, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, TGFBR2, GAPDHMore
Axitinibhsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Axitinibhsa05418Fluid shear stress and atherosclerosis3.54E-0716Q16539, P31751, P42338, Q14145, P14598, P10599, P14780, P01375, P63261, P04637, P10415, P14778, P27930, P0DP23, P08238, Q92974MAPK14, AKT2, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, ACTG1, TP53, BCL2, IL1R1, IL1R2, CALM1, HSP90AB1, ARHGEF2More

Community members of Axitinib (SDC: 12.50)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O00767SCDStearoylNoneCoA desaturasePredicted10.16860.1870.19970.6581
P18054ALOX12Polyunsaturated fatty acid lipoxygenase ALOX12Predicted00.00750.37030.24160.986
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
Q13822ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Predicted00.1130.3050.00630.6729
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
Q15788NCOA1Nuclear receptor coactivator 1Predicted00.43680.08280.31140.6954
P62942FKBP1APeptidylNoneprolyl cisNonetrans isomerase FKBP1APredicted10.4320.269500.7551
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
Q9UGN5PARP2Poly [ADPNoneribose] polymerase 2Predicted00.04350.26350.24610.7947
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
P63279UBE2ISUMONoneconjugating enzyme UBC9Predicted00.23320.05120.49830.7173
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
O15294OGTUDPNoneNNoneacetylglucosamineNoneNonepeptide NNoneacetylglucosaminyltransferase 110 kDa subunitPredicted00.27390.06020.10210.3594
Q96EB6SIRT1NADNonedependent protein deacetylase sirtuinNone1Predicted10.28650.45710.57841.6358
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
Q15722LTB4RLeukotriene B4 receptor 1Predicted00.06770.219900.4736
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
Q86Z02HIPK1HomeodomainNoneinteracting protein kinase 1Predicted00.46310.28160.2181.0128
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P13866SLC5A1Sodium/glucose cotransporter 1Predicted00.37190.11050.1050.512
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
Q2M2I8AAK1AP2Noneassociated protein kinase 1Predicted10.37690.328800.846
Q15831STK11Serine/threonineNoneprotein kinase STK11Predicted00.15110.24410.45491.0186
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P20839IMPDH1InosineNone5'Nonemonophosphate dehydrogenase 1Predicted00.19280.13070.16530.5231
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
Q04759PRKCQProtein kinase C theta typePredicted00.04050.42440.61731.4864
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
O00141SGKSerine/threonineNoneprotein kinase Sgk1Predicted00.24130.30370.30591.034
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P43250GRK6G proteinNonecoupled receptor kinase 6Predicted10.15470.09550.29480.5632
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
Q07817BCL2L1BclNone2Nonelike protein 1Predicted10.08720.434911.9134
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
Q13093PLA2G7PlateletNoneactivating factor acetylhydrolasePredicted00.05050.20960.15580.6001
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P30304CDC25AMNonephase inducer phosphatase 1Predicted00.17950.23470.42740.9865
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
Q16762TSTThiosulfate sulfurtransferasePredicted00.19330.14580.16810.5563
Q9UBU7DBF4Protein DBF4 homolog APredicted00.00750.19610.2590.655
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
O43451MGAMMaltaseNoneglucoamylasePredicted10.19540.16780.1910.6242
Q16875PFKFB36NonephosphofructoNone2Nonekinase/fructoseNone2,6Nonebisphosphatase 3Predicted10.04620.08860.23420.4345
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P22894MMP8Neutrophil collagenasePredicted10.10610.35700.767
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P00374DHFRDihydrofolate reductasePredicted00.3380.18680.22630.7688
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
Q9Y6K0CEPT1Choline/ethanolaminephosphotransferase 1Predicted00.22610.01630.15910.3047
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)