PharmaCoNets of Avanafil (SPCN: 284.09 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Avanafilhsa00010Glycolysis / Gluconeogenesis1.89E-035P04075, P14550, P11766, P07195, P60174ALDOA, AKR1A1, ADH5, LDHB, TPI1More
Avanafilhsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Avanafilhsa00030Pentose phosphate pathway1.80E-094P60891, P51854, P52209, P37837PRPS1, TKTL1, PGD, TALDO1More
Avanafilhsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Avanafilhsa00051Fructose and mannose metabolism2.63E-055P15121, P19367, P08237, P60174, P04075AKR1B1, HK1, PFKM, TPI1, ALDOAMore
Avanafilhsa00052Galactose metabolism4.25E-056P06280, P08237, O43451, P15121, P19367, Q14376GLA, PFKM, MGAM, AKR1B1, HK1, GALEMore
Avanafilhsa00071Fatty acid degradation2.38E-023P11310, O75521, P33121ACADM, ECI2, ACSL1More
Avanafilhsa00100Steroid biosynthesis3.94E-021P35610SOAT1More
Avanafilhsa00190Oxidative phosphorylation4.50E-063Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Avanafilhsa00220Arginine biosynthesis2.76E-053P15104, P05089, P49448GLUL, ARG1, GLUD2More
Avanafilhsa00230Purine metabolism3.35E-022Q7LG56, P51828RRM2B, ADCY7More
Avanafilhsa00250Alanine, aspartate and glutamate metabolism6.84E-053Q96RQ9, P49448, P15104IL4I1, GLUD2, GLULMore
Avanafilhsa00270Cysteine and methionine metabolism2.39E-022Q96RQ9, P40926IL4I1, MDH2More
Avanafilhsa00280Valine, leucine and isoleucine degradation1.93E-046P55809, Q9HCC0, Q96RQ9, P05166, Q02252, P11310OXCT1, MCCC2, IL4I1, PCCB, ALDH6A1, ACADMMore
Avanafilhsa00310Lysine degradation2.14E-057Q9NVH6, Q96KQ7, Q8NEZ4, Q13029, O15047, Q02809, P51648TMLHE, EHMT2, MLL3, PRDM2, SETD1A, PLOD1, ALDH3A2More
Avanafilhsa00330Arginine and proline metabolism2.73E-021P17707AMD1More
Avanafilhsa00380Tryptophan metabolism3.02E-021Q16613AANATMore
Avanafilhsa00410beta-Alanine metabolism3.98E-021Q6ZQY3GADL1More
Avanafilhsa00471D-Glutamine and D-glutamate metabolism1.54E-032Q7Z3D6, P49448C14orf159, GLUD2More
Avanafilhsa00500Starch and sucrose metabolism6.81E-074O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Avanafilhsa00510N-Glycan biosynthesis1.10E-034O94777, P15907, Q9BVK2, Q9NR34DPM2, ST6GAL1, ALG8, MAN1C1More
Avanafilhsa00513Various types of N-glycan biosynthesis4.83E-021Q9NR34MAN1C1More
Avanafilhsa00520Amino sugar and nucleotide sugar metabolism1.75E-063Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Avanafilhsa00531Glycosaminoglycan degradation3.78E-021P15586GNSMore
Avanafilhsa00562Inositol phosphate metabolism4.54E-045Q9NRR6, P27987, O14732, P19174, P42338INPP5E, ITPKB, IMPA2, PLCG1, PIK3CBMore
Avanafilhsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.28E-032O94777, Q14442DPM2, PIGHMore
Avanafilhsa00564Glycerophospholipid metabolism1.25E-046P48651, Q9Y6K0, P35790, P23743, O14494, Q3LIE5PTDSS1, CEPT1, CHKA, DGKA, PLPP1, ADPRMMore
Avanafilhsa00590Arachidonic acid metabolism2.97E-021P09917ALOX5More
Avanafilhsa00600Sphingolipid metabolism7.73E-045Q9BX95, O14494, Q06136, P06280, P15289SGPP1, PLPP1, FVT1, GLA, ARSAMore
Avanafilhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.27E-072P06865, O75752HEXA, B3GALNT1More
Avanafilhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Avanafilhsa00620Pyruvate metabolism9.80E-044P40926, P07195, P14550, P11766MDH2, LDHB, AKR1A1, ADH5More
Avanafilhsa00630Glyoxylate and dicarboxylate metabolism5.29E-084P40925, P40926, P05166, P15104MDH1, MDH2, PCCB, GLULMore
Avanafilhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Avanafilhsa00670One carbon pool by folate1.72E-053O95954, P04818, Q99707FTCD, TYMS, MTRMore
Avanafilhsa00730Thiamine metabolism1.55E-032P05186, P24666ALPL, ACP1More
Avanafilhsa00740Riboflavin metabolism4.77E-021P30043BLVRBMore
Avanafilhsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Avanafilhsa00770Pantothenate and CoA biosynthesis7.20E-043O95498, Q6ZQY3, Q9NRN7VNN2, GADL1, AASDHPPTMore
Avanafilhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Avanafilhsa00790Folate biosynthesis1.04E-023Q92820, P05186, P42330GGH, ALPL, AKR1C3More
Avanafilhsa00830Retinol metabolism3.35E-045P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Avanafilhsa00860Porphyrin and chlorophyll metabolism2.26E-033P36551, P53004, P30043CPOX, BLVRA, BLVRBMore
Avanafilhsa00900Terpenoid backbone biosynthesis4.22E-022P49354, Q9UHG3FNTA, PCYOX1More
Avanafilhsa00910Nitrogen metabolism4.40E-032P15104, P49448GLUL, GLUD2More
Avanafilhsa00970Aminoacyl-tRNA biosynthesis3.83E-022P54136, P14868RARS1, DARSMore
Avanafilhsa00983Drug metabolism - other enzymes1.36E-075P04183, P20839, P32320, P05164, Q16772TK1, IMPDH1, CDA, MPO, GSTA3More
Avanafilhsa01040Biosynthesis of unsaturated fatty acids4.28E-021P22307SCP2More
Avanafilhsa01100Metabolic pathways8.01E-0769Q9NR34, Q9Y234, P35790, P05089, P21953, Q16772, Q9UJ14, P30041, P15104, P19367, P42338, Q9Y217, P48426, P27987, Q96DU7, P22557, Q6ZQY3, P32320, Q08828, Q02153, P20839, P22748, P40926, P55809, P06280, O94777, Q16875, O43286, O43451, P53004, Q9Y6K0, P05186, P24666, P15121, P08237, Q86XP1, O95861, Q96RQ9, Q9HCC0, P33121, Q9UHK6, Q86VZ5, Q96G23, P09917, P48651, Q9BVK2, P57054, Q14442, Q9UNP4, Q9H4F1, Q9BX95, Q9BRR6, P32321, P49448, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q969G6, P05166, P14927, P12074, P05496, Q99437, O15239, O15047, Q9NVH6MAN1C1, LIPT1, CHKA, ARG1, BCKDHB, GSTA3, GGTL3, PRDX6, GLUL, HK1, PIK3CB, MTMR6, PIP4K2A, ITPKB, ITPKC, ALAS2, GADL1, CDA, ADCY1, GUCY1B3, IMPDH1, CA4, MDH2, OXCT1, GLA, DPM2, PFKFB3, B4GALT5, MGAM, BLVRA, CEPT1, ALPL, ACP1, AKR1B1, PFKM, DGKH, BPNT1, IL4I1, MCCC2, ACSL1, AMACR, SGMS1, LASS2, ALOX5, PTDSS1, ALG8, PIGP, PIGH, ST3GAL5, ST6GALNAC4, SGPP1, ADPGK, DCTD, GLUD2, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, RFK, PCCB, UQCRB, COX6A1, ATP5G1, ATP6V0B, NDUFA1, SETD1A, TMLHEMore
Avanafilhsa01200Carbon metabolism2.13E-022P52209, P37837PGD, TALDO1More
Avanafilhsa01212Fatty acid metabolism4.62E-022P33121, P11310ACSL1, ACADMMore
Avanafilhsa01230Biosynthesis of amino acids1.89E-046P51854, P60891, Q99707, P50213, P05089, P37837TKTL1, PRPS1, MTR, IDH3A, ARG1, TALDO1More
Avanafilhsa01240Biosynthesis of cofactors2.85E-047Q969G6, P13716, P36551, P22557, O60701, P14618, Q9Y234RFK, ALAD, CPOX, ALAS2, UGDH, PKM2, LIPT1More
Avanafilhsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Avanafilhsa01522Endocrine resistance1.02E-047P04049, Q9UM47, P04637, P42773, P08069, P10415, Q13323RAF1, NOTCH3, TP53, CDKN2C, IGF1R, BCL2, BIKMore
Avanafilhsa01523Antifolate resistance1.48E-055P41440, Q92820, P04818, P01375, P18054SLC19A1, GGH, TYMS, TNF, ALOX12More
Avanafilhsa01524Platinum drug resistance2.37E-058Q13489, Q14790, P48023, P78417, P40692, P23025, P52701, P31751BIRC3, CASP8, FASLG, GSTO1, MLH1, XPA, MSH6, AKT2More
Avanafilhsa02010ABC transporters1.98E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Avanafilhsa03010Ribosome2.33E-1118P26373, P62753, P42677, P25398, P32969, P62917, P46776, Q9H0U6, Q07020, P62899, P62910, P18077, P61927, Q02878, P36578, P27635, P05386, P23396RPL13, RPS6, RPS27, RPS12, RPL9, RPL8, RPL27A, MRPL18, RPL18, RPL31, RPL32, RPL35A, RPL37, RPL6, RPL4, RPL10, RPLP1, RPS3More
Avanafilhsa03013RNA transport1.52E-1829P62826, O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q9H307, Q7Z3B4, P35658, P63279, P68104, P47813, O14602, Q14152, P55884, O15371, O75822, P78345, Q9H777, P11940, P20042, Q14240, Q9BZI7, Q9Y6A5, Q14232, Q06787, P51114RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, PNN, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF1AY, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, ELAC1, PABPC1, EIF2S2, EIF4A2, UPF3B, TACC3, EIF2B1, FMR1, FXR1More
Avanafilhsa03015mRNA surveillance pathway4.81E-022Q9BZI7, O94913UPF3B, PCF11More
Avanafilhsa03020RNA polymerase7.29E-084P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Avanafilhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Avanafilhsa03040Spliceosome7.91E-0715Q14562, O43143, O60508, P08579, P26368, O75940, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, SMNDC1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Avanafilhsa03050Proteasome4.83E-021P55036PSMD4More
Avanafilhsa03060Protein export1.53E-104Q15070, P37108, O76094, Q15005OXA1L, SRP14, SRP72, SPCS2More
Avanafilhsa03320PPAR signaling pathway4.93E-034Q6PCB7, O00767, Q9UNU6, Q02318SLC27A1, SCD, CYP8B1, CYP27A1More
Avanafilhsa03430Mismatch repair4.38E-021P20585MSH3More
Avanafilhsa03450Non-homologous end-joining4.32E-021Q9NP87POLMMore
Avanafilhsa03460Fanconi anemia pathway8.90E-043P40692, O60673, Q9UNA4MLH1, REV3L, POLIMore
Avanafilhsa04010MAPK signaling pathway8.69E-054P04049, P08069, Q9H2K8, Q12933RAF1, IGF1R, TAOK3, TRAF2More
Avanafilhsa04012ErbB signaling pathway3.61E-057Q13153, P16333, Q13191, P19174, P42338, P01106, P04049PAK1, NCK1, CBLB, PLCG1, PIK3CB, MYC, RAF1More
Avanafilhsa04014Ras signaling pathway2.30E-054P04049, P31751, P08069, P0DP23RAF1, AKT2, IGF1R, CALM1More
Avanafilhsa04015Rap1 signaling pathway3.20E-076P04049, P08069, P06213, O00522, P31751, P0DP23RAF1, IGF1R, INSR, KRIT1, AKT2, CALM1More
Avanafilhsa04020Calcium signaling pathway2.78E-0612Q96DU7, Q08828, P21796, P45880, Q13557, P21860, P30679, P0DP24, P0DP23, P05141, P51828, P23634ITPKC, ADCY1, VDAC1, VDAC2, CAMK2D, ERBB3, GNA15, CALM2, CALM1, SLC25A5, ADCY7, ATP2B4More
Avanafilhsa04022cGMP-PKG signaling pathway1.32E-0712Q02153, P04049, Q99941, P18848, P23634, P31751, Q08828, P51828, P05141, P45880, P0DP24, P0DP23GUCY1B3, RAF1, CREBL1, ATF4, ATP2B4, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2, CALM1More
Avanafilhsa04024cAMP signaling pathway1.08E-046Q08828, P51828, P31751, P0DP23, P04049, Q13153ADCY1, ADCY7, AKT2, CALM1, RAF1, PAK1More
Avanafilhsa04060Cytokine-cytokine receptor interaction6.46E-0517P14784, P27930, P14778, P37173, P26842, Q06643, Q13651, Q9HBE5, P78552, P25024, Q9UBD3, P47992, P09341, P19875, P80075, P01730, Q93038IL2RB, IL1R2, IL1R1, TGFBR2, CD27, LTB, IL10RA, IL21R, IL13RA1, CXCR1, XCL2, XCL1, CXCL1, CXCL2, CCL8, CD4, TNFRSF25More
Avanafilhsa04061Viral protein interaction with cytokine and cytokine receptor1.98E-0510Q8NHW4, P09341, P25024, P02775, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CCL4L2, CXCL1, CXCR1, PPBP, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Avanafilhsa04062Chemokine signaling pathway4.07E-0518P25024, P09341, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q13009, P14598, P42224, P04049, P25963CXCR1, CXCL1, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, TIAM1, NCF1, STAT1, RAF1, NFKBIAMore
Avanafilhsa04064NF-kappa B signaling pathway1.03E-1525P10415, Q13489, P51617, O00463, Q13546, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Avanafilhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Avanafilhsa04068FoxO signaling pathway4.41E-054P04049, P08069, P48023, Q96BR1RAF1, IGF1R, FASLG, SGK3More
Avanafilhsa04070Phosphatidylinositol signaling system7.50E-0612P19174, P0DP23, Q14643, O14986, P23743, P49619, Q86XP1, Q16760, P48426, P27987, Q96DU7, P17252PLCG1, CALM1, ITPR1, PIP5K1B, DGKA, DGKG, DGKH, DGKD, PIP4K2A, ITPKB, ITPKC, PRKCAMore
Avanafilhsa04071Sphingolipid signaling pathway4.07E-0611P04049, P17252, P21453, Q9H228, P01375, Q96G23, Q13362, Q9BX95, P10415, Q12933, Q02156RAF1, PRKCA, S1PR1, EDG8, TNF, LASS2, PPP2R5C, SGPP1, BCL2, TRAF2, PRKCEMore
Avanafilhsa04072Phospholipase D signaling pathway4.96E-058P04049, P31751, Q9UQC2, O14986, Q15438, Q08828, P51828, Q16760RAF1, AKT2, GAB2, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Avanafilhsa04080Neuroactive ligand-receptor interaction1.97E-0411P08311, P78334, Q15722, P21453, Q9H228, P43657, P21462, P21730, P30939, P07550, P35318CTSG, GABRE, LTB4R, S1PR1, EDG8, P2RY5, FPR1, C5AR1, HTR1F, ADRB2, ADMMore
Avanafilhsa04110Cell cycle4.62E-0712Q9UBD5, P30260, P06493, O60566, Q14683, P04637, P49918, P30304, P33981, P42773, P01106, Q13547ORC3, CDC27, CDK1, BUB1B, SMC1A, TP53, CDKN1C, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Avanafilhsa04114Oocyte meiosis5.73E-1011Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1RMore
Avanafilhsa04115p53 signaling pathway2.54E-023O15151, Q13315, P10415MDM4, ATM, BCL2More
Avanafilhsa04120Ubiquitin mediated proteolysis1.08E-036Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12More
Avanafilhsa04136Autophagy - other7.59E-032O94817, Q9H1Y0ATG12, ATG5More
Avanafilhsa04137Mitophagy - animal1.41E-033P67870, P19532, P18848CSNK2B, TFE3, ATF4More
Avanafilhsa04140Autophagy - animal3.90E-0515P08069, Q9Y4H2, P42338, P31751, P04049, Q7L523, Q9NQL2, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9IGF1R, IRS2, PIK3CB, AKT2, RAF1, RRAGA, RRAGD, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Avanafilhsa04141Protein processing in endoplasmic reticulum1.13E-0412P18848, Q12933, P30101, Q15436, P60604, Q99941, P11142, Q9H3Z4, P07900, P08238, Q9NR31, Q9UNL2ATF4, TRAF2, PDIA3, SEC23A, UBE2G2, CREBL1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SAR1A, SSR3More
Avanafilhsa04142Lysosome1.11E-0511O14773, P06865, P22304, P38571, Q13510, Q9UJJ9, P07602, Q9NRA2, P49279, P61916, Q04900TPP1, HEXA, IDS, LIPA, ASAH1, GNPTG, PSAP, SLC17A5, SLC11A1, NPC2, CD164More
Avanafilhsa04144Endocytosis8.76E-0719Q13191, P0DMV8, P11142, Q9H444, O43633, O75351, P62491, P25024, Q96B97, P43250, Q6WKZ4, Q15438, Q8WU79, Q14161, P14784, O95219, O75154, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, CHMP2A, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, RAB11FIP1, PSCD1, SMAP1L, GIT2, IL2RB, SNX4, RAB11FIP3, SNX12, SNX5More
Avanafilhsa04145Phagosome6.70E-0811O75015, Q15080, P14598, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P13765FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Avanafilhsa04146Peroxisome1.43E-024O00623, P56589, Q9UKG9, P33121PEX12, PEX3, CROT, ACSL1More
Avanafilhsa04150mTOR signaling pathway5.20E-042P08069, P04049IGF1R, RAF1More
Avanafilhsa04151PI3K-Akt signaling pathway2.54E-0727P62753, P21860, P25116, O43521, P04637, P27348, P49767, Q13362, P07900, P62873, P61952, P16144, P02452, P24821, Q16363, P22105, O60603, P23458, P01568, Q99941, P18848, P10415, P17252, Q96BR1, O00141, Q6ZUJ8, P56279RPS6, ERBB3, F2R, BCL2L11, TP53, YWHAQ, VEGFC, PPP2R5C, HSP90AA1, GNB1, GNG11, ITGB4, COL1A1, TNC, LAMA4, TNXB, TLR2, JAK1, IFNA21, CREBL1, ATF4, BCL2, PRKCA, SGK3, SGK, PIK3AP1, TCL1AMore
Avanafilhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Avanafilhsa04210Apoptosis1.10E-034Q14790, P48023, P42575, P04049CASP8, FASLG, CASP2, RAF1More
Avanafilhsa04211Longevity regulating pathway2.60E-046P31751, P08069, Q08828, P51828, P18848, Q96RR4AKT2, IGF1R, ADCY1, ADCY7, ATF4, CAMKK2More
Avanafilhsa04213Longevity regulating pathway - multiple species1.23E-079P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Avanafilhsa04217Necroptosis1.10E-1124P01375, Q12933, P01568, P23458, P48023, Q13489, Q9NQC7, Q13546, P42224, Q14765, P07900, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, P10415, Q13557, Q9H444, O43633, O75351, P45880, Q08752TNF, TRAF2, IFNA21, JAK1, FASLG, BIRC3, CYLD, RIPK1, STAT1, STAT4, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, BCL2, CAMK2D, CHMP4B, CHMP2A, VPS4B, VDAC2, PPIDMore
Avanafilhsa04218Cellular senescence1.96E-047P31751, P04049, P30281, P0DP23, P01889, P10321, P12236AKT2, RAF1, CCND3, CALM1, HLA-B, HLA-C, SLC25A6More
Avanafilhsa04260Cardiac muscle contraction4.20E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Avanafilhsa04261Adrenergic signaling in cardiomyocytes6.80E-0915P09493, P67936, Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, P0DP24, Q13557, P17252, P10415, P23634TPM1, TPM4, ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CALM2, CAMK2D, PRKCA, BCL2, ATP2B4More
Avanafilhsa04270Vascular smooth muscle contraction1.71E-0611P24723, Q04759, Q14643, P0DP23, P04049, Q08828, P51828, P22694, P35579, P35749, P35318PRKCH, PRKCQ, ITPR1, CALM1, RAF1, ADCY1, ADCY7, PRKACB, MYH9, MYH11, ADMMore
Avanafilhsa04310Wnt signaling pathway2.28E-045P30279, Q13485, O43318, P17612, P67870CCND2, SMAD4, MAP3K7, PRKACA, CSNK2BMore
Avanafilhsa04330Notch signaling pathway4.54E-044Q92542, P49768, P46531, Q9UM47NCSTN, PSEN1, NOTCH1, NOTCH3More
Avanafilhsa04340Hedgehog signaling pathway2.58E-034P17612, P22694, Q13635, P10415PRKACA, PRKACB, PTCH1, BCL2More
Avanafilhsa04360Axon guidance4.12E-047P16298, Q05397, Q13873, P42338, P04049, O14639, P24844PPP3CB, PTK2, BMPR2, PIK3CB, RAF1, ABLIM1, MYL9More
Avanafilhsa04370VEGF signaling pathway6.18E-137P19174, P16298, P31751, P42338, Q05397, Q02750, P04049PLCG1, PPP3CB, AKT2, PIK3CB, PTK2, MAP2K1, RAF1More
Avanafilhsa04371Apelin signaling pathway1.43E-049P62873, P61952, P31751, P04049, Q08828, P51828, P62753, P0DP23, P0DP24GNB1, GNG11, AKT2, RAF1, ADCY1, ADCY7, RPS6, CALM1, CALM2More
Avanafilhsa04380Osteoclast differentiation2.25E-0710Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Avanafilhsa04390Hippo signaling pathway3.37E-055O95835, P04628, Q9UJU2, O43623, Q13489LATS1, WNT1, LEF1, SNAI2, BIRC3More
Avanafilhsa04392Hippo signaling pathway - multiple species2.11E-053O95835, Q13153, Q6V0I7LATS1, PAK1, FAT4More
Avanafilhsa04510Focal adhesion1.63E-035Q15942, P51636, P30281, P04049, P08069ZYX, CAV2, CCND3, RAF1, IGF1RMore
Avanafilhsa04512ECM-receptor interaction2.77E-056P02452, P24821, P07359, P26012, P08514, P16070COL1A1, TNC, GP1BA, ITGB8, ITGA2B, CD44More
Avanafilhsa04520Adherens junction1.81E-033Q13485, O43318, P08069SMAD4, MAP3K7, IGF1RMore
Avanafilhsa04530Tight junction3.02E-023Q8TEU7, O00501, P24844RAPGEF6, CLDN5, MYL9More
Avanafilhsa04540Gap junction6.48E-056P17252, Q13509, P68371, P04049, Q9NRA1, Q14643PRKCA, TUBB3, TUBB2C, RAF1, PDGFC, ITPR1More
Avanafilhsa04550Signaling pathways regulating pluripotency of stem cells1.61E-035Q13873, P04049, Q02750, P08069, Q86SE9BMPR2, RAF1, MAP2K1, IGF1R, PCGF5More
Avanafilhsa04610Complement and coagulation cascades1.68E-105P09871, P00734, P0C0L4, P20023, P05107C1S, F2, C4A, CR2, ITGB2More
Avanafilhsa04611Platelet activation2.65E-056Q9Y490, P08514, Q15746, Q8WYR1, P17612, P07359TLN1, ITGA2B, MYLK, PIK3R5, PRKACA, GP1BAMore
Avanafilhsa04612Antigen processing and presentation1.36E-0811P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, P01732, P30101, P11142, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, PDIA3, HSPA8, TNFMore
Avanafilhsa04613Neutrophil extracellular trap formation1.78E-0729P19174, P17252, P04049, P16109, P11215, O60603, P05164, P08246, Q9UM07, Q13547, P04908, Q6FI13, Q99878, Q93077, P62807, Q16778, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359, O43315, Q16539PLCG1, PRKCA, RAF1, SELP, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC4; H2AC8, H2AC18; H2AC19, H2AC14, HIST1H2AC, HIST1H2BC, HIST2H2BE, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14More
Avanafilhsa04620Toll-like receptor signaling pathway2.48E-055Q13546, P01568, P01584, P31751, Q8NHW4RIPK1, IFNA21, IL1B, AKT2, CCL4L2More
Avanafilhsa04621NOD-like receptor signaling pathway2.55E-0312P01584, P07900, Q14643, P23458, P45880, P10599, P43490, O00463, P29728, P01375, P09341, P12838IL1B, HSP90AA1, ITPR1, JAK1, VDAC2, TXN, PBEF1, TRAF5, OAS2, TNF, CXCL1, DEFA4More
Avanafilhsa04622RIG-I-like receptor signaling pathway1.29E-075P01568, Q9NQC7, Q13546, Q12933, P10145IFNA21, CYLD, RIPK1, TRAF2, IL8More
Avanafilhsa04623Cytosolic DNA-sensing pathway1.82E-105P01584, P01568, Q13546, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, POLR3H, CCL4L2More
Avanafilhsa04625C-type lectin receptor signaling pathway4.61E-0810Q9ULY5, P04049, Q13153, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, RAF1, PAK1, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Avanafilhsa04630JAK-STAT signaling pathway1.01E-048P01106, P31751, P42224, P23458, P14784, P16871, Q13651, P04049MYC, AKT2, STAT1, JAK1, IL2RB, IL7R, IL10RA, RAF1More
Avanafilhsa04640Hematopoietic cell lineage7.44E-1017P13612, P07359, P08514, P14778, P27930, P11215, P15144, P20023, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375ITGA4, GP1BA, ITGA2B, IL1R1, IL1R2, ITGAM, ANPEP, CR2, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNFMore
Avanafilhsa04650Natural killer cell mediated cytotoxicity5.38E-1918P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, P04049, Q13153, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, PAK1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Avanafilhsa04657IL-17 signaling pathway3.80E-0613P25963, P07900, P08238, O00463, Q12933, Q07955, Q16539, P49841, P09341, P14780, P80188, P01375, P06702NFKBIA, HSP90AA1, HSP90AB1, TRAF5, TRAF2, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, S100A9More
Avanafilhsa04658Th1 and Th2 cell differentiation7.85E-3117P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, Q9UM47, P13765, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, NOTCH3, HLA-DOB, RUNX3More
Avanafilhsa04659Th17 cell differentiation2.98E-2118P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, Q13485, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Avanafilhsa04660T cell receptor signaling pathway3.85E-2119P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, Q13153, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, PAK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Avanafilhsa04662B cell receptor signaling pathway3.04E-1213P31751, P42338, P20023, P60033, P13164, P16298, Q8WV28, P07948, P11912, P21854, Q8N149, Q02750, P04049AKT2, PIK3CB, CR2, CD81, IFITM1, PPP3CB, BLNK, LYN, CD79A, CD72, LILRA2, MAP2K1, RAF1More
Avanafilhsa04664Fc epsilon RI signaling pathway1.57E-068P01375, P31751, Q16539, P42338, Q9UQC2, P07948, P04049, P09917TNF, AKT2, MAPK14, PIK3CB, GAB2, LYN, RAF1, ALOX5More
Avanafilhsa04666Fc gamma R-mediated phagocytosis4.61E-034P08637, O75015, P04049, P06396FCGR3A, FCGR3B, RAF1, GSNMore
Avanafilhsa04668TNF signaling pathway4.51E-0511P01375, Q12933, O00463, Q16539, Q99941, P18848, P01584, P20749, P14780, P20333, O95429TNF, TRAF2, TRAF5, MAPK14, CREBL1, ATF4, IL1B, BCL3, MMP9, TNFRSF1B, BAG4More
Avanafilhsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Avanafilhsa04710Circadian rhythm4.86E-021O15516CLOCKMore
Avanafilhsa04713Circadian entrainment1.85E-0710P0DP23, P0DP24, Q13557, Q02153, P17252, P62873, P61952, Q14643, Q08828, P51828CALM1, CALM2, CAMK2D, GUCY1B3, PRKCA, GNB1, GNG11, ITPR1, ADCY1, ADCY7More
Avanafilhsa04714Thermogenesis9.00E-044Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Avanafilhsa04720Long-term potentiation9.48E-1112P17252, Q13557, P16298, P0DP23, P0DP24, Q15418, P51812, P18848, Q08828, Q02750, P04049, Q14643PRKCA, CAMK2D, PPP3CB, CALM1, CALM2, RPS6KA1, RPS6KA3, ATF4, ADCY1, MAP2K1, RAF1, ITPR1More
Avanafilhsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Avanafilhsa04722Neurotrophin signaling pathway1.76E-0610Q05655, P31751, P04049, P49841, O43524, P48023, P52566, P51617, P10415, P0DP23PRKCD, AKT2, RAF1, GSK3B, FOXO3, FASLG, ARHGDIB, IRAK1, BCL2, CALM1More
Avanafilhsa04723Retrograde endocannabinoid signaling1.69E-037Q14643, P17252, P62873, P61952, Q08828, O15239, Q16718ITPR1, PRKCA, GNB1, GNG11, ADCY1, NDUFA1, NDUFA5More
Avanafilhsa04724Glutamatergic synapse2.84E-057O15399, Q08828, P62873, P63218, P50151, P61952, P15104GRIN2D, ADCY1, GNB1, GNG5, GNG10, GNG11, GLULMore
Avanafilhsa04725Cholinergic synapse3.22E-0713Q08828, P51828, Q14643, P17252, P62873, P63218, P50151, P61952, P18848, Q13557, P42338, P31751, P10415ADCY1, ADCY7, ITPR1, PRKCA, GNB1, GNG5, GNG10, GNG11, ATF4, CAMK2D, PIK3CB, AKT2, BCL2More
Avanafilhsa04726Serotonergic synapse1.33E-021P04049RAF1More
Avanafilhsa04727GABAergic synapse6.02E-089Q08828, P51828, P62873, P63218, P50151, P61952, P15104, P46459, Q15111ADCY1, ADCY7, GNB1, GNG5, GNG10, GNG11, GLUL, NSF, PLCL1More
Avanafilhsa04728Dopaminergic synapse1.32E-0918Q14643, P17252, P62873, P50151, P61952, P31751, P49841, Q99941, P18848, Q16539, Q13557, P49407, Q13362, Q14738, P0DP23, P0DP24, O15516, P48058ITPR1, PRKCA, GNB1, GNG10, GNG11, AKT2, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, PPP2R5C, PPP2R5D, CALM1, CALM2, CLOCK, GRIA4More
Avanafilhsa04730Long-term depression1.25E-042P08069, P04049IGF1R, RAF1More
Avanafilhsa04740Olfactory transduction4.52E-054P62873, Q13557, P0DP23, P0DP24GNB1, CAMK2D, CALM1, CALM2More
Avanafilhsa04742Taste transduction1.18E-032P30939, P17612HTR1F, PRKACAMore
Avanafilhsa04744Phototransduction1.02E-083P62873, P0DP23, P0DP24GNB1, CALM1, CALM2More
Avanafilhsa04750Inflammatory mediator regulation of TRP channels8.03E-0911P14778, P01584, Q08828, P51828, Q13557, P19174, P42338, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM2, CALM1More
Avanafilhsa04810Regulation of actin cytoskeleton1.78E-026Q13009, P04049, P11215, P16144, P60709, P01042TIAM1, RAF1, ITGAM, ITGB4, ACTB, KNG1More
Avanafilhsa04910Insulin signaling pathway2.40E-053P0DP23, P04049, P31751CALM1, RAF1, AKT2More
Avanafilhsa04911Insulin secretion1.04E-065Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Avanafilhsa04912GnRH signaling pathway1.15E-069P17252, Q08828, P51828, P18848, Q9Y6R4, Q14643, P0DP23, P04049, P45985PRKCA, ADCY1, ADCY7, ATF4, MAP3K4, ITPR1, CALM1, RAF1, MAP2K4More
Avanafilhsa04913Ovarian steroidogenesis8.40E-042P06213, P08069INSR, IGF1RMore
Avanafilhsa04914Progesterone-mediated oocyte maturation1.58E-086P08069, Q17RY0, Q9Y6D9, P51812, Q02750, P04049IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1More
Avanafilhsa04915Estrogen signaling pathway8.54E-1012P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, P0DP24, Q15788RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, CALM2, NCOA1More
Avanafilhsa04916Melanogenesis7.31E-044P0DP23, Q08828, P51828, P04049CALM1, ADCY1, ADCY7, RAF1More
Avanafilhsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Avanafilhsa04918Thyroid hormone synthesis2.47E-045Q08828, Q99941, P18848, P02768, P05543ADCY1, CREBL1, ATF4, ALB, SERPINA7More
Avanafilhsa04919Thyroid hormone signaling pathway1.21E-047P19174, P04049, P42224, P60709, Q13547, Q9UM47, P01106PLCG1, RAF1, STAT1, ACTB, HDAC1, NOTCH3, MYCMore
Avanafilhsa04920Adipocytokine signaling pathway4.19E-021P31751AKT2More
Avanafilhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Avanafilhsa04922Glucagon signaling pathway3.10E-047P14618, P06737, Q12778, P31751, Q13370, P0DP23, Q14643PKM2, PYGL, FOXO1, AKT2, PDE3B, CALM1, ITPR1More
Avanafilhsa04923Regulation of lipolysis in adipocytes5.39E-064Q08828, P51828, P06213, P31751ADCY1, ADCY7, INSR, AKT2More
Avanafilhsa04924Renin secretion8.24E-075P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Avanafilhsa04925Aldosterone synthesis and secretion1.79E-088Q99941, P18848, Q08828, P51828, P0DP24, P0DP23, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CALM1, CAMK2D, ATP2B4More
Avanafilhsa04926Relaxin signaling pathway1.62E-0714P31751, P42338, P62873, P63218, P50151, P61952, Q99941, P18848, P49767, Q08828, P51828, P04049, P30679, P49407AKT2, PIK3CB, GNB1, GNG5, GNG10, GNG11, CREBL1, ATF4, VEGFC, ADCY1, ADCY7, RAF1, GNA15, ARRB1More
Avanafilhsa04927Cortisol synthesis and secretion2.32E-054Q99941, P18848, Q08828, P51828CREBL1, ATF4, ADCY1, ADCY7More
Avanafilhsa04928Parathyroid hormone synthesis, secretion and action1.99E-021P04049RAF1More
Avanafilhsa04929GnRH secretion6.93E-064P42338, P31751, P49407, P04049PIK3CB, AKT2, ARRB1, RAF1More
Avanafilhsa04930Type II diabetes mellitus6.29E-053P06213, Q05655, Q02156INSR, PRKCD, PRKCEMore
Avanafilhsa04932Non-alcoholic fatty liver disease1.87E-1316P31751, P01375, P49841, Q14790, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, Q16718, O95298, P19404, O14521AKT2, TNF, GSK3B, CASP8, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHDMore
Avanafilhsa04933AGE-RAGE signaling pathway in diabetic complications1.27E-025P42224, P10415, Q12778, P49767, P17252STAT1, BCL2, FOXO1, VEGFC, PRKCAMore
Avanafilhsa04934Cushing syndrome5.10E-076Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Avanafilhsa04935Growth hormone synthesis, secretion and action5.87E-046Q08828, P51828, P04049, P18848, P31751, P45985ADCY1, ADCY7, RAF1, ATF4, AKT2, MAP2K4More
Avanafilhsa04940Type I diabetes mellitus7.38E-044P10747, P48023, P13765, P01375CD28, FASLG, HLA-DOB, TNFMore
Avanafilhsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Avanafilhsa04961Endocrine and other factor-regulated calcium reabsorption2.68E-023P20020, Q9UEF7, P17252ATP2B1, KL, PRKCAMore
Avanafilhsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Avanafilhsa04966Collecting duct acid secretion1.95E-033Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Avanafilhsa04970Salivary secretion2.10E-0910P07550, Q08828, P51828, P22694, Q14643, P23634, P0DP24, P0DP23, Q02153, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B4, CALM2, CALM1, GUCY1B3, CAMPMore
Avanafilhsa04971Gastric acid secretion3.36E-076Q08828, P51828, P15311, P0DP24, P0DP23, Q13557ADCY1, ADCY7, VIL2, CALM2, CALM1, CAMK2DMore
Avanafilhsa04972Pancreatic secretion2.68E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Avanafilhsa04973Carbohydrate digestion and absorption2.41E-021P31751AKT2More
Avanafilhsa04974Protein digestion and absorption1.22E-032Q7Z2H8, P02452SLC36A1, COL1A1More
Avanafilhsa04975Fat digestion and absorption4.83E-021O14494PLPP1More
Avanafilhsa04976Bile secretion1.38E-055O43315, Q08828, P51828, P08183, Q14032AQP9, ADCY1, ADCY7, ABCB1, BAATMore
Avanafilhsa04979Cholesterol metabolism1.37E-023P38571, P61916, P45880LIPA, NPC2, VDAC2More
Avanafilhsa05010Alzheimer disease1.66E-0926P49768, Q92542, O15239, Q16718, O95298, P19404, O14521, P05496, P13073, P12074, Q14643, Q00535, O75460, P0DP23, P01584, Q12933, P18848, Q13509, P68371, O15169, P67870, P31751, P05141, Q08752, P28070, P43686PSEN1, NCSTN, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, CDK5, ERN1, CALM1, IL1B, TRAF2, ATF4, TUBB3, TUBB2C, AXIN1, CSNK2B, AKT2, SLC25A5, PPID, PSMB4, PSMC4More
Avanafilhsa05012Parkinson disease4.93E-0519O15239, Q16718, O95298, O14521, P13073, P12074, P05496, P05141, P12236, O75460, P18848, P28070, P43686, Q14643, P0DP23, P0DP24, Q13557, Q13509, P68371NDUFA1, NDUFA5, NDUFC2, SDHD, COX4I1, COX6A1, ATP5G1, SLC25A5, SLC25A6, ERN1, ATF4, PSMB4, PSMC4, ITPR1, CALM1, CALM2, CAMK2D, TUBB3, TUBB2CMore
Avanafilhsa05014Amyotrophic lateral sclerosis4.18E-025P19404, P12074, O75460, P28070, Q8TEV9NDUFV2, COX6A1, ERN1, PSMB4, SMCR8More
Avanafilhsa05016Huntington disease1.51E-0612O95298, P19404, P13073, P12074, P24928, P30876, P62487, P05141, P45880, O75460, P28070, O00232NDUFC2, NDUFV2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, VDAC2, ERN1, PSMB4, PSMD12More
Avanafilhsa05017Spinocerebellar ataxia1.88E-049Q92915, O75460, Q8TB72, O15399, P42338, P31751, P28070, P05141, P21796FGF14, ERN1, PUM2, GRIN2D, PIK3CB, AKT2, PSMB4, SLC25A5, VDAC1More
Avanafilhsa05020Prion disease6.43E-0825P01584, P46531, P0DMV8, P11142, O15239, Q16718, O95298, O14521, P05496, P13073, P12074, Q14643, P18848, P05141, P12236, P28070, P43686, Q13509, P68371, P49841, P67870, Q99941, P14598, Q15080, Q16539IL1B, NOTCH1, HSPA1A, HSPA8, NDUFA1, NDUFA5, NDUFC2, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, ATF4, SLC25A5, SLC25A6, PSMB4, PSMC4, TUBB3, TUBB2C, GSK3B, CSNK2B, CREBL1, NCF1, NCF4, MAPK14More
Avanafilhsa05022Pathways of neurodegeneration - multiple diseases2.71E-1137Q14643, Q13509, P68371, P49841, P67870, P10415, O15239, Q16718, O95298, P19404, O14521, P13073, P12074, P05496, Q06055, Q8TEV9, O75460, P18848, Q12933, Q13561, P05141, P45880, P17252, Q16539, Q15078, Q00535, O15169, P01584, P49768, Q08752, O15020, P0DP23, P0DP24, Q13557, P62987, P28070, P43686ITPR1, TUBB3, TUBB2C, GSK3B, CSNK2B, BCL2, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHD, COX4I1, COX6A1, ATP5G1, ATP5G2, SMCR8, ERN1, ATF4, TRAF2, DCTN2, SLC25A5, VDAC2, PRKCA, MAPK14, CDK5R1, CDK5, AXIN1, IL1B, PSEN1, PPID, SPTBN2, CALM1, CALM2, CAMK2D, UBA52, PSMB4, PSMC4More
Avanafilhsa05030Cocaine addiction5.99E-033Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Avanafilhsa05031Amphetamine addiction4.45E-055P0DP24, P0DP23, Q13557, Q99941, P18848CALM2, CALM1, CAMK2D, CREBL1, ATF4More
Avanafilhsa05032Morphine addiction5.68E-032P78334, P32298GABRE, GRK4More
Avanafilhsa05033Nicotine addiction4.01E-021P78334GABREMore
Avanafilhsa05034Alcoholism4.25E-0410Q99941, P18848, Q13547, P0DP24, P62873, P61952, P04049, P0C0S5, P62807, Q16778CREBL1, ATF4, HDAC1, CALM2, GNB1, GNG11, RAF1, H2AFZ, HIST1H2BC, HIST2H2BEMore
Avanafilhsa05100Bacterial invasion of epithelial cells3.14E-033Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Avanafilhsa05110Vibrio cholerae infection2.11E-032Q99437, P17612ATP6V0B, PRKACAMore
Avanafilhsa05120Epithelial cell signaling in Helicobacter pylori infection2.55E-1010Q16539, Q99437, Q13153, P09341, P19875, P10145, P19174, P25024, P25025, P41240MAPK14, ATP6V0B, PAK1, CXCL1, CXCL2, IL8, PLCG1, CXCR1, CXCR2, CSKMore
Avanafilhsa05130Pathogenic Escherichia coli infection2.77E-039P16333, Q13509, P60709, P25963, P04406, P29350, Q15438, P35579, P55061NCK1, TUBB3, ACTB, NFKBIA, GAPDH, PTPN6, PSCD1, MYH9, TEGTMore
Avanafilhsa05131Shigellosis3.55E-0618Q12933, Q13546, P68431, Q05655, Q02156, Q9UDY8, Q9NQL2, P0CG47, Q14141, Q14247, Q96JJ3, Q05397, Q14643, Q12778, Q13315, P10415, Q08752, P07737TRAF2, RIPK1, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCD, PRKCE, MALT1, RRAGD, UBB, SEPT6, CTTN, ELMO2, PTK2, ITPR1, FOXO1, ATM, BCL2, PPID, PFN1More
Avanafilhsa05132Salmonella infection7.23E-1120P51617, P25963, P08238, P04049, Q9UJU2, P01106, P84095, P60709, Q13546, Q13489, P10415, P04406, O75369, P07737, O60603, Q9BQS8, Q13561, Q13509, P68371, P49754IRAK1, NFKBIA, HSP90AB1, RAF1, LEF1, MYC, RHOG, ACTB, RIPK1, BIRC3, BCL2, GAPDH, FLNB, PFN1, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C, VPS41More
Avanafilhsa05133Pertussis1.20E-064P05107, P0DP23, P10145, P0C0L4ITGB2, CALM1, IL8, C4AMore
Avanafilhsa05134Legionellosis2.58E-089P01584, P25963, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875IL1B, NFKBIA, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2More
Avanafilhsa05135Yersinia infection1.86E-048Q05397, P51812, P06239, P19174, Q02750, P42338, Q96JJ3, P01732PTK2, RPS6KA3, LCK, PLCG1, MAP2K1, PIK3CB, ELMO2, CD8AMore
Avanafilhsa05140Leishmaniasis1.39E-0813P13612, O75015, P14598, P11215, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, NCF4More
Avanafilhsa05142Chagas disease2.70E-022P48023, Q14790FASLG, CASP8More
Avanafilhsa05143African trypanosomiasis1.71E-054P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Avanafilhsa05144Malaria6.72E-059P60033, P69905, P68871, O60603, P01375, P05107, P35443, P10145, P26718CD81, HBA2, HBB, TLR2, TNF, ITGB2, THBS4, IL8, KLRK1More
Avanafilhsa05145Toxoplasmosis1.11E-026P10415, Q13489, P42224, P13765, O60603, P29965BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Avanafilhsa05146Amoebiasis1.14E-1412P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Avanafilhsa05150Staphylococcus aureus infection5.41E-0815P09871, P0C0L4, P21730, P21462, O75015, P31995, P13765, P13646, Q14532, P05107, P16109, P59665, P59666, P12838, P49913C1S, C4A, C5AR1, FPR1, FCGR3B, FCGR2C, HLA-DOB, KRT13, KRT32, ITGB2, SELP, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Avanafilhsa05152Tuberculosis4.93E-0713P04049, Q13488, P0DP23, P42224, P48382, P25208, O60603, P31751, P10415, P13765, P01568, Q9UDY8, P51617RAF1, TCIRG1, CALM1, STAT1, RFX5, NFYB, TLR2, AKT2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1More
Avanafilhsa05160Hepatitis C2.07E-0510Q13546, P01568, P60033, O00501, P29728, P04049, P49841, P01375, P48023, P01106RIPK1, IFNA21, CD81, CLDN5, OAS2, RAF1, GSK3B, TNF, FASLG, MYCMore
Avanafilhsa05161Hepatitis B4.32E-034P04049, Q99941, P18848, P27348RAF1, CREBL1, ATF4, YWHAQMore
Avanafilhsa05162Measles5.20E-046P23458, P31751, P0DMV8, P01584, P67870, Q9NP90JAK1, AKT2, HSPA1A, IL1B, CSNK2B, RAB9BMore
Avanafilhsa05163Human cytomegalovirus infection1.28E-1024P31751, P04049, P01375, P62873, P50151, P61952, Q14643, P0DP23, P0DP24, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, Q99941, P18848, P04637, O00463, P61769AKT2, RAF1, TNF, GNB1, GNG10, GNG11, ITPR1, CALM1, CALM2, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TP53, TRAF5, B2MMore
Avanafilhsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Avanafilhsa05165Human papillomavirus infection7.06E-0517P16144, P02452, P24821, Q16363, Q05086, P30281, Q9UM47, P01568, P42224, P01889, P10321, Q13488, Q99437, Q13362, Q12778, P04628, Q13315ITGB4, COL1A1, TNC, LAMA4, UBE3A, CCND3, NOTCH3, IFNA21, STAT1, HLA-B, HLA-C, TCIRG1, ATP6V0B, PPP2R5C, FOXO1, WNT1, ATMMore
Avanafilhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Avanafilhsa05167Kaposi sarcoma-associated herpesvirus infection8.92E-0511P01568, P31751, P42224, P25963, P62873, P19174, Q14643, P04049, P01106, P0DP23, Q9UJU2IFNA21, AKT2, STAT1, NFKBIA, GNB1, PLCG1, ITPR1, RAF1, MYC, CALM1, LEF1More
Avanafilhsa05168Herpes simplex virus 1 infection4.64E-0317O00463, O60603, P25963, Q05823, Q07955, Q01130, Q16629, Q9Y2A4, P51522, Q9NR11, P17097, P17038, Q03923, P52738, O75820, Q9UDV6, P10415TRAF5, TLR2, NFKBIA, RNASEL, SFRS1, SFRS2, SFRS7, ZNF443, ZNF83, ZNF302, ZNF7, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212, BCL2More
Avanafilhsa05169Epstein-Barr virus infection1.72E-0617P13765, P01106, Q13547, O00463, P10415, P42338, P07948, Q13761, P24522, O75293, P42224, P01375, O60603, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, BCL2, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, STAT1, TNF, TLR2, OAS2, CD3E, CD3G, CD247More
Avanafilhsa05170Human immunodeficiency virus 1 infection6.35E-0917P31751, P04049, Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, Q13546, Q14643, P01568, P51617, O60603, Q13315, P10415, Q9Y6Q5AKT2, RAF1, MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, RIPK1, ITPR1, IFNA21, IRAK1, TLR2, ATM, BCL2, AP1M2More
Avanafilhsa05171Coronavirus disease - COVID-193.96E-0917P23396, P62753, P25398, P42677, P36578, Q02878, P62917, P32969, P27635, P26373, Q07020, P46776, P62899, P62910, P18077, P61927, P05386RPS3, RPS6, RPS12, RPS27, RPL4, RPL6, RPL8, RPL9, RPL10, RPL13, RPL18, RPL27A, RPL31, RPL32, RPL35A, RPL37, RPLP1More
Avanafilhsa05200Pathways in cancer9.39E-0730P08238, P42224, P25963, P19174, P01106, Q9UJU2, P17252, P43246, Q13485, P20585, P52701, P14923, P30279, P10415, Q13489, Q13077, P49767, P14921, Q12778, P31751, P25116, P62873, P63218, Q9UM47, P78417, O75293, P0DP23, P01568, P14784, P01042HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, LEF1, PRKCA, MSH2, SMAD4, MSH3, MSH6, JUP, CCND2, BCL2, BIRC3, TRAF1, VEGFC, ETS1, FOXO1, AKT2, F2R, GNB1, GNG5, NOTCH3, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, KNG1More
Avanafilhsa05202Transcriptional misregulation in cancer3.63E-0921Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45AMore
Avanafilhsa05203Viral carcinogenesis4.16E-0513Q12933, Q99941, P18848, P30281, P27348, Q13547, P06396, P12814, P01889, P10321, P06493, P62807, Q16778TRAF2, CREBL1, ATF4, CCND3, YWHAQ, HDAC1, GSN, ACTN1, HLA-B, HLA-C, CDK1, HIST1H2BC, HIST2H2BEMore
Avanafilhsa05205Proteoglycans in cancer8.81E-0616Q13009, Q12955, Q14643, O75369, P60709, P04049, P14780, P17252, O60603, P01106, P08069, P04628, P19174, Q13635, P29350, P08962TIAM1, ANK3, ITPR1, FLNB, ACTB, RAF1, MMP9, PRKCA, TLR2, MYC, IGF1R, WNT1, PLCG1, PTCH1, PTPN6, CD63More
Avanafilhsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Avanafilhsa05210Colorectal cancer1.47E-049Q9UKG1, Q13485, P43246, P04049, P01106, P52701, P20585, P37173, O75293APPL1, SMAD4, MSH2, RAF1, MYC, MSH6, MSH3, TGFBR2, GADD45BMore
Avanafilhsa05211Renal cell carcinoma5.09E-053Q13153, P31751, P04049PAK1, AKT2, RAF1More
Avanafilhsa05212Pancreatic cancer5.93E-044P31751, P04049, Q15311, P23458AKT2, RAF1, RALBP1, JAK1More
Avanafilhsa05213Endometrial cancer8.16E-042P31751, P04049AKT2, RAF1More
Avanafilhsa05214Glioma6.68E-066P08069, P0DP23, P04049, P31751, P19174, O75293IGF1R, CALM1, RAF1, AKT2, PLCG1, GADD45BMore
Avanafilhsa05215Prostate cancer2.34E-045P10415, Q12778, P08069, Q9NRA1, P04049BCL2, FOXO1, IGF1R, PDGFC, RAF1More
Avanafilhsa05217Basal cell carcinoma4.31E-022P04628, Q9UJU2WNT1, LEF1More
Avanafilhsa05218Melanoma5.24E-063P08069, P31751, P04049IGF1R, AKT2, RAF1More
Avanafilhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Avanafilhsa05220Chronic myeloid leukemia9.63E-042P31751, P04049AKT2, RAF1More
Avanafilhsa05221Acute myeloid leukemia8.73E-045P31751, P42338, P04049, Q15744, P11215AKT2, PIK3CB, RAF1, CEBPE, ITGAMMore
Avanafilhsa05222Small cell lung cancer4.78E-021P31751AKT2More
Avanafilhsa05223Non-small cell lung cancer3.49E-042P31751, P04049AKT2, RAF1More
Avanafilhsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Avanafilhsa05225Hepatocellular carcinoma1.65E-042P04049, P08069RAF1, IGF1RMore
Avanafilhsa05226Gastric cancer6.81E-042P04049, P31751RAF1, AKT2More
Avanafilhsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Avanafilhsa05231Choline metabolism in cancer2.51E-069P04049, P31751, Q9Y259, P19174, P23743, P49619, Q16760, O14986, O14494RAF1, AKT2, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PLPP1More
Avanafilhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.46E-1417P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P29350, P04049, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, RAF1, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Avanafilhsa05310Asthma7.64E-083P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Avanafilhsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Avanafilhsa05321Inflammatory bowel disease6.18E-147O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Avanafilhsa05322Systemic lupus erythematosus6.78E-0715P08637, O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, P62807, Q16778, P68431, P14678, P12814FCGR3A, FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2BC, HIST2H2BE, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SNRPB, ACTN1More
Avanafilhsa05323Rheumatoid arthritis7.52E-068P01375, Q06643, P13765, Q13488, P10747, P09341, P19875, O60603TNF, LTB, HLA-DOB, TCIRG1, CD28, CXCL1, CXCL2, TLR2More
Avanafilhsa05330Allograft rejection7.88E-055P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Avanafilhsa05332Graft-versus-host disease4.96E-126P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Avanafilhsa05340Primary immunodeficiency2.96E-046P01730, P01732, P11912, Q8WV28, P07766, P06239CD4, CD8A, CD79A, BLNK, CD3E, LCKMore
Avanafilhsa05410Hypertrophic cardiomyopathy3.63E-022P26012, P09493ITGB8, TPM1More
Avanafilhsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Avanafilhsa05414Dilated cardiomyopathy3.78E-034P54284, P26012, P09493, P26678CACNB3, ITGB8, TPM1, PLNMore
Avanafilhsa05415Diabetic cardiomyopathy2.31E-0510P17252, P30405, P14598, Q15080, Q16718, O14521, Q16539, P49841, P14780, P37173PRKCA, PPIF, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, MMP9, TGFBR2More
Avanafilhsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Avanafilhsa05418Fluid shear stress and atherosclerosis1.27E-0510Q16539, P31751, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1More

Community members of Avanafil (SDC: 11.27)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
Q8IVH8MAP4K3MitogenNoneactivated protein kinase kinase kinase kinase 3Predicted00.38330.26730.14870.875
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P09769FGRTyrosineNoneprotein kinase FgrPredicted00.06220.32440.2250.9049
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
O14976GAKCyclinNoneGNoneassociated kinasePredicted10.57280.256200.7989
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
Q9Y6R4MAP3K4MitogenNoneactivated protein kinase kinase kinase 4Predicted00.35280.24520.1730.8399
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
Q9P289STK26Serine/threonineNoneprotein kinase 26Predicted10.02850.262800.5399
Q8NI60CABC1Atypical kinase COQ8A, mitochondrialPredicted00.62760.245200.8043
P51813BMXCytoplasmic tyrosineNoneprotein kinase BMXPredicted00.05970.326300.6825
P42681TXKTyrosineNoneprotein kinase TXKPredicted00.28040.30260.19130.9367
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P24723PRKCHProtein kinase C eta typePredicted00.19550.32940.20480.9614
Q15418RPS6KA1Ribosomal protein S6 kinase alphaNone1Predicted10.8320.32450.41461.4796
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
Q15746MYLKMyosin light chain kinase, smooth musclePredicted00.04010.31160.42981.0731
Q96RR4CAMKK2Calcium/calmodulinNonedependent protein kinase kinase 2Predicted00.36280.34060.46511.3277
Q9UEE5STK17ASerine/threonineNoneprotein kinase 17APredicted00.35040.337600.8504
Q2M2I8AAK1AP2Noneassociated protein kinase 1Predicted10.37690.328800.846
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q05655PRKCDProtein kinase C delta typePredicted00.08160.41940.65441.5339
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
Q07912TNK2Activated CDC42 kinase 1Predicted00.0090.347200.6988
Q99759MAP3K3MitogenNoneactivated protein kinase kinase kinase 3Predicted00.35450.24520.43781.1055
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
Q13153PAK1Serine/threonineNoneprotein kinase PAK 1Predicted10.46470.34710.78191.7084
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P22694PRKACBcAMPNonedependent protein kinase catalytic subunit betaPredicted00.37370.298411.7836
Q9Y6E0STK24Serine/threonineNoneprotein kinase 24Predicted00.54580.245200.7634
Q92630DYRK2Dual specificity tyrosineNonephosphorylationNoneregulated kinase 2Predicted00.17790.349400.7877
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
Q13523PRPF4BSerine/threonineNoneprotein kinase PRP4 homologPredicted00.13760.245200.5593
P49760CLK2Dual specificity protein kinase CLK2Predicted00.03030.295100.6053
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
O95835LATS1Serine/threonineNoneprotein kinase LATS1Predicted00.43320.24520.02170.7288
O43283MAP3K13MitogenNoneactivated protein kinase kinase kinase 13Predicted00.45650.24520.14870.8674
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P51817PRKXcAMPNonedependent protein kinase catalytic subunit PRKXPredicted00.40630.276500.7562
O95747OXSR1Serine/threonineNoneprotein kinase OSR1Predicted00.18390.245200.5825
Q00536PCTK1CyclinNonedependent kinase 16Predicted00.27140.25600.6478
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
Q16513PKN2Serine/threonineNoneprotein kinase N2Predicted00.04210.27780.33910.9157
Q04759PRKCQProtein kinase C theta typePredicted00.04050.42440.61731.4864
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
Q9UEW8STK39STE20/SPS1Nonerelated prolineNonealanineNonerich protein kinasePredicted00.25730.245200.6191
Q96BR1SGK3Serine/threonineNoneprotein kinase Sgk3Predicted00.0260.26840.31140.8612
Q02156PRKCEProtein kinase C epsilon typePredicted00.11750.52870.53771.6539
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
Q9H422HIPK3HomeodomainNoneinteracting protein kinase 3Predicted00.3650.25080.2180.902
O94806PRKD3Serine/threonineNoneprotein kinase D3Predicted00.23120.24340.16920.7715
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
Q13557CAMK2DCalcium/calmodulinNonedependent protein kinase type II subunit deltaPredicted00.47780.3060.80951.6604
Q15831STK11Serine/threonineNoneprotein kinase STK11Predicted00.15110.24410.45491.0186
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
Q8IVW4CDKL3CyclinNonedependent kinaseNonelike 3Predicted00.41490.241600.6906
Q13873BMPR2Bone morphogenetic protein receptor typeNone2Predicted10.34760.24520.35481.019
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
O75460ERN1Serine/threonineNoneprotein kinase/endoribonuclease IRE1Predicted10.68060.29440.5571.4862
P51617IRAK1InterleukinNone1 receptorNoneassociated kinase 1Predicted00.02380.30.94441.5563
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
Q16566CAMK4Calcium/calmodulinNonedependent protein kinase type IVPredicted00.07180.24410.61761.1417
P19784CSNK2A2Casein kinase II subunit alpha'Predicted10.09660.32250.52971.2231
P21860ERBB3Receptor tyrosineNoneprotein kinase erbBNone3Predicted00.1260.27290.47881.0876
P07332FESTyrosineNoneprotein kinase Fes/FpsPredicted00.27220.26280.15130.8131
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q9H2K8TAOK3Serine/threonineNoneprotein kinase TAO3Predicted00.06460.24520.14870.6715
Q9NQU5PAK6Serine/threonineNoneprotein kinase PAK 6Predicted00.4090.26690.50031.2386
Q9HAZ1CLK4Dual specificity protein kinase CLK4Predicted00.28830.31110.15870.9251
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
O43318MAP3K7MitogenNoneactivated protein kinase kinase kinase 7Predicted00.00590.364911.7327
Q86Z02HIPK1HomeodomainNoneinteracting protein kinase 1Predicted00.46310.28160.2181.0128
P32298GRK4G proteinNonecoupled receptor kinase 4Predicted00.03520.23860.29480.7896
P45985MAP2K4Dual specificity mitogenNoneactivated protein kinase kinase 4Predicted00.42480.24730.74031.4474
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
O00767SCDStearoylNoneCoA desaturasePredicted10.16860.1870.19970.6581
Q9UDY8MALT1MucosaNoneassociated lymphoid tissue lymphoma translocation protein 1Predicted10.05160.1470.55920.8789
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P13612ITGA4Integrin alphaNone4Predicted00.11650.23860.68621.2217
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)