PharmaCoNets of Astemizole (SPCN: 296.29 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Astemizolehsa00030Pentose phosphate pathway1.63E-074P60891, P51854, P52209, P37837PRPS1, TKTL1, PGD, TALDO1More
Astemizolehsa00040Pentose and glucuronate interconversions4.00E-021P15121AKR1B1More
Astemizolehsa00052Galactose metabolism1.06E-032P06280, O43451GLA, MGAMMore
Astemizolehsa00053Ascorbate and aldarate metabolism5.61E-032P51648, Q9UEF7ALDH3A2, KLMore
Astemizolehsa00071Fatty acid degradation4.66E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Astemizolehsa00120Primary bile acid biosynthesis3.72E-022P22680, P22307CYP7A1, SCP2More
Astemizolehsa00130Ubiquinone and other terpenoid-quinone biosynthesis1.66E-021Q9BQB6VKORC1More
Astemizolehsa00190Oxidative phosphorylation1.28E-053Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Astemizolehsa00220Arginine biosynthesis7.34E-053P15104, P05089, P49448GLUL, ARG1, GLUD2More
Astemizolehsa00230Purine metabolism4.93E-021P21589NT5EMore
Astemizolehsa00240Pyrimidine metabolism3.20E-032P21589, P04183NT5E, TK1More
Astemizolehsa00250Alanine, aspartate and glutamate metabolism2.64E-043Q96RQ9, P49448, P15104IL4I1, GLUD2, GLULMore
Astemizolehsa00270Cysteine and methionine metabolism2.39E-022Q96RQ9, P40926IL4I1, MDH2More
Astemizolehsa00280Valine, leucine and isoleucine degradation1.91E-058P21953, P55809, Q9HCC0, Q96RQ9, P05166, P51648, Q02252, P11310BCKDHB, OXCT1, MCCC2, IL4I1, PCCB, ALDH3A2, ALDH6A1, ACADMMore
Astemizolehsa00310Lysine degradation1.33E-044Q9NVH6, Q96KQ7, O15047, P51648TMLHE, EHMT2, SETD1A, ALDH3A2More
Astemizolehsa00500Starch and sucrose metabolism5.92E-094O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Astemizolehsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Astemizolehsa00512Mucin type O-glycan biosynthesis3.19E-033O95395, Q8N4A0, Q9NY28GCNT3, GALNT4, GALNT8More
Astemizolehsa00513Various types of N-glycan biosynthesis4.96E-021Q9NR34MAN1C1More
Astemizolehsa00520Amino sugar and nucleotide sugar metabolism1.59E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Astemizolehsa00564Glycerophospholipid metabolism4.29E-022Q6P1A2, P23743MBOAT5, DGKAMore
Astemizolehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Astemizolehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Astemizolehsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Astemizolehsa00603Glycosphingolipid biosynthesis - globo and isoglobo series7.10E-032P06865, O75752HEXA, B3GALNT1More
Astemizolehsa00630Glyoxylate and dicarboxylate metabolism5.77E-114P40925, P40926, P05166, P15104MDH1, MDH2, PCCB, GLULMore
Astemizolehsa00670One carbon pool by folate1.33E-022P04818, Q99707TYMS, MTRMore
Astemizolehsa00730Thiamine metabolism2.43E-062P05186, P24666ALPL, ACP1More
Astemizolehsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Astemizolehsa00760Nicotinate and nicotinamide metabolism9.09E-031P21589NT5EMore
Astemizolehsa00770Pantothenate and CoA biosynthesis2.26E-043O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Astemizolehsa00790Folate biosynthesis2.02E-021P15121AKR1B1More
Astemizolehsa00830Retinol metabolism3.93E-023P00352, Q9BPW9, O75911ALDH1A1, DHRS9, DHRS3More
Astemizolehsa00910Nitrogen metabolism1.97E-022P15104, P49448GLUL, GLUD2More
Astemizolehsa00970Aminoacyl-tRNA biosynthesis1.60E-084O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Astemizolehsa00980Metabolism of xenobiotics by cytochrome P4506.38E-043P78417, P09211, P11712GSTO1, GSTP1, CYP2C9More
Astemizolehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Astemizolehsa00983Drug metabolism - other enzymes8.04E-065P04183, P20839, P32320, P05164, Q16772TK1, IMPDH1, CDA, MPO, GSTA3More
Astemizolehsa01100Metabolic pathways3.18E-0340Q9NR34, P05089, Q9UJ14, P15104, Q96DU7, P32320, Q08828, Q02153, P22748, P40926, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q86XP1, Q96RQ9, Q9HCC0, P33121, Q9UHK6, P57054, Q9UNP4, Q9H4F1, Q9BX95, Q9BRR6, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, P05166, P12074, P05496, O15239, O15047, Q9NVH6MAN1C1, ARG1, GGTL3, GLUL, ITPKC, CDA, ADCY1, GUCY1B3, CA4, MDH2, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, DGKH, IL4I1, MCCC2, ACSL1, AMACR, PIGP, ST3GAL5, ST6GALNAC4, SGPP1, ADPGK, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, PCCB, COX6A1, ATP5G1, NDUFA1, SETD1A, TMLHEMore
Astemizolehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Astemizolehsa01212Fatty acid metabolism4.62E-022P33121, P11310ACSL1, ACADMMore
Astemizolehsa01230Biosynthesis of amino acids2.26E-034P51854, P60891, P05089, P37837TKTL1, PRPS1, ARG1, TALDO1More
Astemizolehsa01240Biosynthesis of cofactors2.95E-022P13716, P14618ALAD, PKM2More
Astemizolehsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Astemizolehsa01522Endocrine resistance4.47E-042P04049, P08069RAF1, IGF1RMore
Astemizolehsa01523Antifolate resistance1.88E-034P41440, Q92820, P04818, P01375SLC19A1, GGH, TYMS, TNFMore
Astemizolehsa01524Platinum drug resistance2.26E-047Q13489, P98170, P78417, P40692, P23025, P43246, P31751BIRC3, BIRC4, GSTO1, MLH1, XPA, MSH2, AKT2More
Astemizolehsa02010ABC transporters1.98E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Astemizolehsa03010Ribosome2.00E-0914P62753, P40429, P62906, P62829, P46776, Q07020, P62888, P61927, P61513, P36578, P27635, P05386, P62249, P23396RPS6, RPL13A, RPL10A, RPL23, RPL27A, RPL18, RPL30, RPL37, RPL37A, RPL4, RPL10, RPLP1, RPS16, RPS3More
Astemizolehsa03013RNA transport3.90E-0721P62826, P52298, Q09161, O14893, P38919, Q15287, Q9UBU9, P37198, P35658, P63279, P68104, P47813, O14602, Q14152, P55884, O15371, O75822, P78345, P20042, Q14232, P51114RAN, NCBP2, NCBP1, GEMIN2, EIF4A3, RNPS1, NXF1, NUP62, NUP214, UBE2I, EEF1A1, EIF1AX, EIF1AY, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, EIF2S2, EIF2B1, FXR1More
Astemizolehsa03020RNA polymerase5.70E-074P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Astemizolehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Astemizolehsa03040Spliceosome1.58E-1521Q14562, O43143, O60508, P17844, P08579, Q15427, P26368, O75940, P51991, P38159, P61978, O75494, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, DDX5, SNRPB2, SF3B4, U2AF2, SMNDC1, HNRPA3, RBMX, HNRPK, FUSIP1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Astemizolehsa03050Proteasome5.43E-033P55036, P62195, P40306PSMD4, PSMC5, PSMB10More
Astemizolehsa03060Protein export1.20E-032P37108, Q15005SRP14, SPCS2More
Astemizolehsa03320PPAR signaling pathway4.33E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Astemizolehsa03430Mismatch repair4.38E-021P20585MSH3More
Astemizolehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Astemizolehsa03460Fanconi anemia pathway2.71E-021O94782USP1More
Astemizolehsa04010MAPK signaling pathway1.69E-032P04049, P08069RAF1, IGF1RMore
Astemizolehsa04012ErbB signaling pathway6.03E-047P21860, P16333, Q13557, P19174, O14944, P01106, P04049ERBB3, NCK1, CAMK2D, PLCG1, EREG, MYC, RAF1More
Astemizolehsa04014Ras signaling pathway2.01E-0615P04049, P31751, P42338, P20827, Q9NRA1, P49767, P08069, Q13009, P17252, Q7LDG7, P0DP23, P62873, P63218, P50151, P19174RAF1, AKT2, PIK3CB, EFNA1, PDGFC, VEGFC, IGF1R, TIAM1, PRKCA, RASGRP2, CALM1, GNB1, GNG5, GNG10, PLCG1More
Astemizolehsa04015Rap1 signaling pathway5.53E-0719P04049, P20827, Q9NRA1, P49767, P08069, P06213, Q96FS4, P11215, P25116, Q8TEU7, Q13009, O00522, Q7LDG7, P42338, P31751, P0DP23, P08514, P17252, P19174RAF1, EFNA1, PDGFC, VEGFC, IGF1R, INSR, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, KRIT1, RASGRP2, PIK3CB, AKT2, CALM1, ITGA2B, PRKCA, PLCG1More
Astemizolehsa04020Calcium signaling pathway1.23E-0514Q96DU7, Q08828, P45880, Q13557, P17252, P21860, P19174, P0DP23, P05141, P51828, P20020, P23634, Q9NRA1, P49767ITPKC, ADCY1, VDAC2, CAMK2D, PRKCA, ERBB3, PLCG1, CALM1, SLC25A5, ADCY7, ATP2B1, ATP2B4, PDGFC, VEGFCMore
Astemizolehsa04022cGMP-PKG signaling pathway1.31E-0612P04049, Q99941, P18848, P23634, Q8WYR1, P31751, Q08828, P51828, P05141, P45880, P0DP24, P0DP23RAF1, CREBL1, ATF4, ATP2B4, PIK3R5, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2, CALM1More
Astemizolehsa04024cAMP signaling pathway5.33E-045Q08828, P51828, P31751, P0DP23, P04049ADCY1, ADCY7, AKT2, CALM1, RAF1More
Astemizolehsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Astemizolehsa04061Viral protein interaction with cytokine and cytokine receptor1.83E-049Q8NHW4, P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RBMore
Astemizolehsa04062Chemokine signaling pathway1.58E-1024P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P14598, P42224, P04049, P25963, P49841, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, NCF1, STAT1, RAF1, NFKBIA, GSK3B, PIK3R5More
Astemizolehsa04064NF-kappa B signaling pathway2.53E-1122P10415, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Astemizolehsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Astemizolehsa04068FoxO signaling pathway3.80E-042P04049, P08069RAF1, IGF1RMore
Astemizolehsa04070Phosphatidylinositol signaling system1.14E-0510P19174, P0DP23, O14986, P23743, Q86XP1, Q16760, P48426, P27987, Q96DU7, P17252PLCG1, CALM1, PIP5K1B, DGKA, DGKH, DGKD, PIP4K2A, ITPKB, ITPKC, PRKCAMore
Astemizolehsa04071Sphingolipid signaling pathway2.29E-057P04049, P21453, Q9H228, P01375, Q13362, Q9BX95, Q9UQC2RAF1, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, GAB2More
Astemizolehsa04072Phospholipase D signaling pathway2.43E-0412P04049, P31751, P42338, P43657, P25024, P25025, P19174, O14986, Q15438, Q08828, P51828, Q16760RAF1, AKT2, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Astemizolehsa04080Neuroactive ligand-receptor interaction1.37E-038P08311, P28472, Q15722, P21453, Q9H228, P21462, P21730, P07550CTSG, GABRB3, LTB4R, S1PR1, EDG8, FPR1, C5AR1, ADRB2More
Astemizolehsa04110Cell cycle8.83E-058Q9UBD5, P06493, O60566, Q14683, P30304, P33981, P42773, P01106ORC3, CDK1, BUB1B, SMC1A, CDC25A, TTK, CDKN2C, MYCMore
Astemizolehsa04114Oocyte meiosis4.24E-0611Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1RMore
Astemizolehsa04115p53 signaling pathway2.54E-023O15151, Q13315, P10415MDM4, ATM, BCL2More
Astemizolehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Astemizolehsa04140Autophagy - animal2.53E-0312P08069, P31751, P04049, Q7L523, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9IGF1R, AKT2, RAF1, RRAGA, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Astemizolehsa04141Protein processing in endoplasmic reticulum1.12E-0716P18848, P30101, Q15437, Q15436, P49257, P60604, Q99941, O75460, P11142, Q9H3Z4, P07900, P08238, Q9NR31, P14625, Q9H173, Q9UNL2ATF4, PDIA3, SEC23B, SEC23A, LMAN1, UBE2G2, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SAR1A, HSP90B1, SIL1, SSR3More
Astemizolehsa04142Lysosome7.47E-059P06865, P22304, P38571, Q13510, Q9UJJ9, P07602, Q9NRA2, P49279, P61916HEXA, IDS, LIPA, ASAH1, GNPTG, PSAP, SLC17A5, SLC11A1, NPC2More
Astemizolehsa04144Endocytosis1.72E-0618Q13191, P0DMV8, P11142, Q9H444, O75351, P62491, P25024, Q96B97, P43250, Q15438, Q8WU79, Q14161, P01889, P10321, P14784, P49418, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, PSCD1, SMAP1L, GIT2, HLA-B, HLA-C, IL2RB, AMPH, SNX12, SNX5More
Astemizolehsa04145Phagosome7.06E-0715O75015, P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P13765, P01889, P10321FCGR3B, ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOB, HLA-B, HLA-CMore
Astemizolehsa04146Peroxisome1.43E-024O00623, P56589, Q9UKG9, P33121PEX12, PEX3, CROT, ACSL1More
Astemizolehsa04150mTOR signaling pathway5.20E-042P08069, P04049IGF1R, RAF1More
Astemizolehsa04151PI3K-Akt signaling pathway9.72E-0726P62753, P42338, P43657, O43521, P27348, P09603, P20827, P49767, Q9GZP0, P07900, P08238, P14625, Q8WYR1, P63218, P50151, P13612, O15335, Q16363, Q13751, P22105, P14784, Q99941, P18848, O00141, Q6ZUJ8, P30281RPS6, PIK3CB, P2RY5, BCL2L11, YWHAQ, CSF1, EFNA1, VEGFC, PDGFD, HSP90AA1, HSP90AB1, HSP90B1, PIK3R5, GNG5, GNG10, ITGA4, CHAD, LAMA4, LAMB3, TNXB, IL2RB, CREBL1, ATF4, SGK, PIK3AP1, CCND3More
Astemizolehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Astemizolehsa04210Apoptosis6.94E-048O76075, P01375, Q9NR28, O75460, Q16548, O43521, P18848, P04049DFFB, TNF, DIABLO, ERN1, BCL2A1, BCL2L11, ATF4, RAF1More
Astemizolehsa04211Longevity regulating pathway3.68E-046P31751, P08069, Q08828, P51828, Q99941, P18848AKT2, IGF1R, ADCY1, ADCY7, CREBL1, ATF4More
Astemizolehsa04213Longevity regulating pathway - multiple species1.91E-059P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Astemizolehsa04217Necroptosis1.61E-1021P01375, P01568, P48023, Q13489, P98170, Q9NQC7, P42224, Q14765, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, Q9H444, O43633, P21796, Q08752TNF, IFNA21, FASLG, BIRC3, BIRC4, CYLD, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP4B, CHMP2A, VDAC1, PPIDMore
Astemizolehsa04218Cellular senescence2.04E-055P31751, P04049, P0DP23, P01889, P10321AKT2, RAF1, CALM1, HLA-B, HLA-CMore
Astemizolehsa04260Cardiac muscle contraction4.02E-022P09493, P14927TPM1, UQCRBMore
Astemizolehsa04261Adrenergic signaling in cardiomyocytes3.40E-0812P07550, Q08828, P51828, P22694, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, Q13557, P23634ADRB2, ADCY1, ADCY7, PRKACB, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CAMK2D, ATP2B4More
Astemizolehsa04270Vascular smooth muscle contraction8.53E-057P0DP23, P04049, Q08828, P51828, P35579, P35749, P35318CALM1, RAF1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Astemizolehsa04330Notch signaling pathway3.88E-053Q92542, P49768, P46531NCSTN, PSEN1, NOTCH1More
Astemizolehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Astemizolehsa04360Axon guidance1.39E-038P16333, P20827, O95631, P17252, P42338, P07332, P04049, P19174NCK1, EFNA1, NTN1, PRKCA, PIK3CB, FES, RAF1, PLCG1More
Astemizolehsa04370VEGF signaling pathway1.26E-065P16298, P31751, Q05397, Q02750, P04049PPP3CB, AKT2, PTK2, MAP2K1, RAF1More
Astemizolehsa04371Apelin signaling pathway4.01E-1015P62873, P63218, P50151, Q8WYR1, P31751, P04049, Q08828, P51828, Q13370, Q14814, Q14344, Q13485, P84022, Q16566, P0DP23GNB1, GNG5, GNG10, PIK3R5, AKT2, RAF1, ADCY1, ADCY7, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, CAMK4, CALM1More
Astemizolehsa04380Osteoclast differentiation2.07E-0510Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Astemizolehsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Astemizolehsa04510Focal adhesion1.18E-032P04049, P08069RAF1, IGF1RMore
Astemizolehsa04512ECM-receptor interaction4.54E-058Q16787, Q13751, P07359, P13612, P26012, P08514, O15335, P16070LAMA3, LAMB3, GP1BA, ITGA4, ITGB8, ITGA2B, CHAD, CD44More
Astemizolehsa04514Cell adhesion molecules3.29E-022P01889, P10321HLA-B, HLA-CMore
Astemizolehsa04520Adherens junction8.29E-031P08069IGF1RMore
Astemizolehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Astemizolehsa04540Gap junction3.28E-066P17252, Q13509, P68371, Q71U36, P04049, Q9NRA1PRKCA, TUBB3, TUBB2C, TUBA1A, RAF1, PDGFCMore
Astemizolehsa04550Signaling pathways regulating pluripotency of stem cells1.61E-035Q13873, P04049, Q02750, P08069, Q86SE9BMPR2, RAF1, MAP2K1, IGF1R, PCGF5More
Astemizolehsa04610Complement and coagulation cascades3.56E-053P09871, P0C0L4, P20023C1S, C4A, CR2More
Astemizolehsa04611Platelet activation9.37E-055P25116, P08514, Q15746, Q8WYR1, P07359F2R, ITGA2B, MYLK, PIK3R5, GP1BAMore
Astemizolehsa04612Antigen processing and presentation3.61E-1112P13765, P48382, P01730, Q14953, P26715, P26717, Q13241, O43908, P01732, P01889, P10321, P01375HLA-DOB, RFX5, CD4, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, HLA-B, HLA-C, TNFMore
Astemizolehsa04613Neutrophil extracellular trap formation2.40E-0725P04049, P16109, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, Q99878, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359, O43315, Q16539RAF1, SELP, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AC14, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14More
Astemizolehsa04620Toll-like receptor signaling pathway4.91E-043P01584, P31751, Q8NHW4IL1B, AKT2, CCL4L2More
Astemizolehsa04621NOD-like receptor signaling pathway2.12E-0310P01584, P07900, Q14643, P10599, P43490, O00463, P29728, P01375, P09341, P12838IL1B, HSP90AA1, ITPR1, TXN, PBEF1, TRAF5, OAS2, TNF, CXCL1, DEFA4More
Astemizolehsa04622RIG-I-like receptor signaling pathway1.81E-021Q9NQC7CYLDMore
Astemizolehsa04623Cytosolic DNA-sensing pathway2.33E-095P01584, P01568, P25963, Q9Y535, Q8NHW4IL1B, IFNA21, NFKBIA, POLR3H, CCL4L2More
Astemizolehsa04625C-type lectin receptor signaling pathway6.67E-0711Q9ULY5, P04049, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP23, Q16539CLEC4E, RAF1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM1, MAPK14More
Astemizolehsa04630JAK-STAT signaling pathway8.73E-034P31751, P23458, Q13651, P04049AKT2, JAK1, IL10RA, RAF1More
Astemizolehsa04640Hematopoietic cell lineage1.69E-0918P13612, P07359, P08514, P14778, P27930, P11215, P15144, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375ITGA4, GP1BA, ITGA2B, IL1R1, IL1R2, ITGAM, ANPEP, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNFMore
Astemizolehsa04650Natural killer cell mediated cytotoxicity5.83E-2121P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, Q29983, P10321, P01889, P42338, Q02750, P04049, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, MICA, HLA-C, HLA-B, PIK3CB, MAP2K1, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Astemizolehsa04657IL-17 signaling pathway2.86E-0915P25963, P07900, P08238, O00463, Q07955, Q16539, P49841, P09341, P19875, P14780, P04141, P80188, P01375, P06702, P01584NFKBIA, HSP90AA1, HSP90AB1, TRAF5, SFRS1, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, CSF2, LCN2, TNF, S100A9, IL1BMore
Astemizolehsa04658Th1 and Th2 cell differentiation4.53E-1814Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Astemizolehsa04659Th17 cell differentiation4.33E-1619P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Astemizolehsa04660T cell receptor signaling pathway4.16E-1722P01375, P04141, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P16333, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P29350, P04049, Q16539, P49841TNF, CSF2, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, PTPN6, RAF1, MAPK14, GSK3BMore
Astemizolehsa04662B cell receptor signaling pathway8.53E-0910P31751, P42338, P20023, P60033, Q8WV28, P07948, P11912, P21854, Q8N149, P04049AKT2, PIK3CB, CR2, CD81, BLNK, LYN, CD79A, CD72, LILRA2, RAF1More
Astemizolehsa04664Fc epsilon RI signaling pathway2.65E-0710P01375, P31751, P04141, Q16539, P42338, Q9UQC2, P07948, P19174, P04049, P09917TNF, AKT2, CSF2, MAPK14, PIK3CB, GAB2, LYN, PLCG1, RAF1, ALOX5More
Astemizolehsa04666Fc gamma R-mediated phagocytosis1.64E-033P04049, P06396, P49418RAF1, GSN, AMPHMore
Astemizolehsa04668TNF signaling pathway2.30E-0511P01375, O00463, Q16539, Q99941, P18848, P19875, P01584, P20749, P14780, P20333, O95429TNF, TRAF5, MAPK14, CREBL1, ATF4, CXCL2, IL1B, BCL3, MMP9, TNFRSF1B, BAG4More
Astemizolehsa04672Intestinal immune network for IgA production1.35E-022P29965, P13765CD40LG, HLA-DOBMore
Astemizolehsa04710Circadian rhythm4.40E-021O15516CLOCKMore
Astemizolehsa04713Circadian entrainment5.45E-0812O15399, P0DP23, Q13557, Q02153, P17252, P62873, P63218, P50151, P61952, Q08828, P51828, O15055GRIN2D, CALM1, CAMK2D, GUCY1B3, PRKCA, GNB1, GNG5, GNG10, GNG11, ADCY1, ADCY7, PER2More
Astemizolehsa04714Thermogenesis1.49E-048Q16539, P51828, P62753, P33121, P12074, O15239, Q16718, O14521MAPK14, ADCY7, RPS6, ACSL1, COX6A1, NDUFA1, NDUFA5, SDHDMore
Astemizolehsa04720Long-term potentiation9.17E-069Q16566, P16298, P0DP23, P51812, P18848, O15399, Q08828, Q02750, P04049CAMK4, PPP3CB, CALM1, RPS6KA3, ATF4, GRIN2D, ADCY1, MAP2K1, RAF1More
Astemizolehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Astemizolehsa04722Neurotrophin signaling pathway7.07E-068Q05655, P31751, P04049, P49841, O43524, P48023, P52566, P0DP23PRKCD, AKT2, RAF1, GSK3B, FOXO3, FASLG, ARHGDIB, CALM1More
Astemizolehsa04724Glutamatergic synapse2.39E-095O15399, P62873, P63218, P50151, P15104GRIN2D, GNB1, GNG5, GNG10, GLULMore
Astemizolehsa04725Cholinergic synapse2.93E-0610Q08828, P51828, P62873, P63218, P50151, P18848, Q16566, Q13557, P42338, P31751ADCY1, ADCY7, GNB1, GNG5, GNG10, ATF4, CAMK4, CAMK2D, PIK3CB, AKT2More
Astemizolehsa04726Serotonergic synapse3.61E-045P62873, P63218, P50151, P09917, P04049GNB1, GNG5, GNG10, ALOX5, RAF1More
Astemizolehsa04727GABAergic synapse6.52E-117Q08828, P62873, P63218, P50151, P61952, P15104, Q15111ADCY1, GNB1, GNG5, GNG10, GNG11, GLUL, PLCL1More
Astemizolehsa04728Dopaminergic synapse1.13E-0513P14416, P63218, P50151, P31751, P49841, Q99941, P18848, Q16539, Q13557, P49407, Q13362, Q14738, P0DP23DRD2, GNG5, GNG10, AKT2, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, PPP2R5C, PPP2R5D, CALM1More
Astemizolehsa04730Long-term depression6.52E-044Q14344, P08069, P04049, P07948GNA13, IGF1R, RAF1, LYNMore
Astemizolehsa04740Olfactory transduction9.46E-042Q9H255, P0DP23OR51E2, CALM1More
Astemizolehsa04742Taste transduction1.01E-021P30939HTR1FMore
Astemizolehsa04744Phototransduction4.56E-072P62873, P0DP23GNB1, CALM1More
Astemizolehsa04750Inflammatory mediator regulation of TRP channels2.98E-0610P14778, P01584, Q08828, P51828, Q13557, P19174, P42338, P24723, Q04759, P0DP23IL1R1, IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1More
Astemizolehsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Astemizolehsa04910Insulin signaling pathway2.43E-056P0DP23, P22694, P06737, P04049, P31751, P49841CALM1, PRKACB, PYGL, RAF1, AKT2, GSK3BMore
Astemizolehsa04911Insulin secretion1.61E-075Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Astemizolehsa04912GnRH signaling pathway1.99E-0510Q08828, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP23, P22694, P04049ADCY1, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM1, PRKACB, RAF1More
Astemizolehsa04913Ovarian steroidogenesis5.67E-044P42330, P22694, P06213, P08069AKR1C3, PRKACB, INSR, IGF1RMore
Astemizolehsa04914Progesterone-mediated oocyte maturation3.18E-056P08069, Q17RY0, Q9Y6D9, P51812, Q02750, P04049IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1More
Astemizolehsa04915Estrogen signaling pathway2.98E-0911P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, Q15788RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, NCOA1More
Astemizolehsa04916Melanogenesis7.31E-044P0DP23, Q08828, P51828, P04049CALM1, ADCY1, ADCY7, RAF1More
Astemizolehsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Astemizolehsa04918Thyroid hormone synthesis1.89E-057P51828, P17252, Q99941, P18848, P14625, P27824, P02768ADCY7, PRKCA, CREBL1, ATF4, HSP90B1, CANX, ALBMore
Astemizolehsa04919Thyroid hormone signaling pathway6.83E-045P49841, P04049, P22694, O60244, Q9NVC6GSK3B, RAF1, PRKACB, MED14, MED17More
Astemizolehsa04920Adipocytokine signaling pathway1.59E-025P33121, Q04759, P31751, Q9Y4H2, P01375ACSL1, PRKCQ, AKT2, IRS2, TNFMore
Astemizolehsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Astemizolehsa04922Glucagon signaling pathway4.86E-044P14618, P06737, P31751, P0DP23PKM2, PYGL, AKT2, CALM1More
Astemizolehsa04923Regulation of lipolysis in adipocytes9.57E-067Q08828, P51828, P07550, P06213, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, INSR, PIK3CB, IRS2, AKT2More
Astemizolehsa04924Renin secretion3.93E-054P22694, P07550, Q14643, P0DP23PRKACB, ADRB2, ITPR1, CALM1More
Astemizolehsa04925Aldosterone synthesis and secretion8.33E-077Q99941, P18848, Q08828, P51828, P0DP23, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM1, CAMK2D, ATP2B4More
Astemizolehsa04926Relaxin signaling pathway9.73E-0714P31751, P42338, P63218, P50151, Q99941, P18848, P22694, P49767, P14780, Q08828, P51828, P04049, P30679, P49407AKT2, PIK3CB, GNG5, GNG10, CREBL1, ATF4, PRKACB, VEGFC, MMP9, ADCY1, ADCY7, RAF1, GNA15, ARRB1More
Astemizolehsa04927Cortisol synthesis and secretion1.02E-055Q99941, P18848, Q08828, P51828, P22694CREBL1, ATF4, ADCY1, ADCY7, PRKACBMore
Astemizolehsa04928Parathyroid hormone synthesis, secretion and action3.95E-034P51828, P04049, Q99941, P18848ADCY7, RAF1, CREBL1, ATF4More
Astemizolehsa04929GnRH secretion2.28E-044P42338, P31751, P49407, P04049PIK3CB, AKT2, ARRB1, RAF1More
Astemizolehsa04930Type II diabetes mellitus1.48E-032P06213, Q05655INSR, PRKCDMore
Astemizolehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Astemizolehsa04932Non-alcoholic fatty liver disease2.91E-0914P31751, P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, Q16718, O95298, O14521AKT2, TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, SDHDMore
Astemizolehsa04933AGE-RAGE signaling pathway in diabetic complications1.52E-038P84022, Q13485, P42224, P42338, Q12778, P49767, P17252, P19174SMAD3, SMAD4, STAT1, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1More
Astemizolehsa04934Cushing syndrome6.14E-086Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Astemizolehsa04935Growth hormone synthesis, secretion and action3.68E-046Q08828, P51828, P04049, Q99941, P18848, P31751ADCY1, ADCY7, RAF1, CREBL1, ATF4, AKT2More
Astemizolehsa04940Type I diabetes mellitus5.32E-056P10747, P48023, P13765, P01889, P10321, P01375CD28, FASLG, HLA-DOB, HLA-B, HLA-C, TNFMore
Astemizolehsa04960Aldosterone-regulated sodium reabsorption7.59E-032O00141, P06213SGK, INSRMore
Astemizolehsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Astemizolehsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Astemizolehsa04966Collecting duct acid secretion4.48E-021P00918CA2More
Astemizolehsa04970Salivary secretion6.57E-087P07550, Q08828, P51828, P22694, Q14643, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, CALM1, CAMPMore
Astemizolehsa04971Gastric acid secretion2.02E-055Q08828, P51828, P15311, P0DP23, Q13557ADCY1, ADCY7, VIL2, CALM1, CAMK2DMore
Astemizolehsa04973Carbohydrate digestion and absorption7.48E-044P13866, O43451, P42338, P31751SLC5A1, MGAM, PIK3CB, AKT2More
Astemizolehsa04976Bile secretion2.12E-067O43315, Q08828, P51828, P22694, P08183, P13866, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, SLC5A1, BAATMore
Astemizolehsa05010Alzheimer disease1.32E-0828P49768, Q92542, O15239, O95298, P05496, P13073, P12074, O15399, Q00535, Q9NZJ5, O75460, P0DP24, P0DP23, Q13564, P01584, Q12933, P18848, Q71U36, O15169, P09603, P31751, P05141, P21796, P45880, P17861, P28070, P43686, P62195PSEN1, NCSTN, NDUFA1, NDUFC2, ATP5G1, COX4I1, COX6A1, GRIN2D, CDK5, EIF2AK3, ERN1, CALM2, CALM1, APPBP1, IL1B, TRAF2, ATF4, TUBA1A, AXIN1, CSF1, AKT2, SLC25A5, VDAC1, VDAC2, XBP1, PSMB4, PSMC4, PSMC5More
Astemizolehsa05012Parkinson disease2.27E-0415Q16718, O14521, P13073, P05141, P60604, O75460, P18848, P17861, P62195, P19174, P0DP23, P0DP24, Q71U36, Q13509, P68371NDUFA5, SDHD, COX4I1, SLC25A5, UBE2G2, ERN1, ATF4, XBP1, PSMC5, PLCG1, CALM1, CALM2, TUBA1A, TUBB3, TUBB2CMore
Astemizolehsa05014Amyotrophic lateral sclerosis2.32E-043P17861, P62195, Q53GS7XBP1, PSMC5, GLE1More
Astemizolehsa05016Huntington disease2.84E-0410O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12More
Astemizolehsa05017Spinocerebellar ataxia5.20E-0410Q92915, O75460, O15399, P42338, P31751, P17861, P28070, P62195, P05141, P21796FGF14, ERN1, GRIN2D, PIK3CB, AKT2, XBP1, PSMB4, PSMC5, SLC25A5, VDAC1More
Astemizolehsa05020Prion disease1.37E-0311P01584, P46531, P11142, Q16718, O14521, P05496, P12074, P45880, P49841, Q99941, Q16539IL1B, NOTCH1, HSPA8, NDUFA5, SDHD, ATP5G1, COX6A1, VDAC2, GSK3B, CREBL1, MAPK14More
Astemizolehsa05022Pathways of neurodegeneration - multiple diseases7.71E-0935Q13509, P68371, P49841, O15239, Q16718, O95298, O14521, P13073, P12074, P05496, Q06055, Q8TEV9, O75460, P18848, P17861, Q12933, Q13561, P19174, P05141, P17252, P20333, Q16539, Q00535, O15169, P01584, P49768, Q08752, O15020, P0DP23, P0DP24, Q13557, P62987, P28070, P43686, P62195TUBB3, TUBB2C, GSK3B, NDUFA1, NDUFA5, NDUFC2, SDHD, COX4I1, COX6A1, ATP5G1, ATP5G2, SMCR8, ERN1, ATF4, XBP1, TRAF2, DCTN2, PLCG1, SLC25A5, PRKCA, TNFRSF1B, MAPK14, CDK5, AXIN1, IL1B, PSEN1, PPID, SPTBN2, CALM1, CALM2, CAMK2D, UBA52, PSMB4, PSMC4, PSMC5More
Astemizolehsa05030Cocaine addiction6.96E-033Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Astemizolehsa05031Amphetamine addiction1.45E-046P0DP23, Q13557, P22694, Q99941, P18848, Q13547CALM1, CAMK2D, PRKACB, CREBL1, ATF4, HDAC1More
Astemizolehsa05032Morphine addiction2.99E-056P62873, P63218, P50151, Q13370, Q07343, P43250GNB1, GNG5, GNG10, PDE3B, PDE4B, GRK6More
Astemizolehsa05034Alcoholism5.33E-0612O15399, Q16566, P0DP23, P62873, P63218, P50151, P04049, Q93077, P62807, Q93079, O60814, P68431GRIN2D, CAMK4, CALM1, GNB1, GNG5, GNG10, RAF1, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Astemizolehsa05100Bacterial invasion of epithelial cells3.14E-033Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Astemizolehsa05110Vibrio cholerae infection1.98E-023Q13488, P17252, P19174TCIRG1, PRKCA, PLCG1More
Astemizolehsa05120Epithelial cell signaling in Helicobacter pylori infection2.05E-0811Q16539, P25963, Q13488, Q99437, P09341, P19875, P19174, P25024, P25025, P41240, P07948MAPK14, NFKBIA, TCIRG1, ATP6V0B, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, CSK, LYNMore
Astemizolehsa05130Pathogenic Escherichia coli infection3.19E-026Q71U36, P16333, Q13509, P68371, Q14344, P25963TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIAMore
Astemizolehsa05131Shigellosis2.58E-0412Q13546, Q05655, Q9UDY8, Q9NQL2, P0CG47, Q14141, Q96JJ3, Q05397, Q12778, Q13315, P10415, P07737RIPK1, PRKCD, MALT1, RRAGD, UBB, SEPT6, ELMO2, PTK2, FOXO1, ATM, BCL2, PFN1More
Astemizolehsa05132Salmonella infection8.83E-0514P25963, P08238, P04049, P84095, Q13546, P10415, P04406, O75369, P07737, Q13561, Q71U36, Q13509, P68371, P49754NFKBIA, HSP90AB1, RAF1, RHOG, RIPK1, BCL2, GAPDH, FLNB, PFN1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41More
Astemizolehsa05133Pertussis3.51E-021P0C0L4C4AMore
Astemizolehsa05134Legionellosis1.05E-048P01584, P25963, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875IL1B, NFKBIA, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2More
Astemizolehsa05135Yersinia infection6.38E-039Q05397, P51812, P13612, P06239, Q16539, Q02750, P01375, P49841, Q96JJ3PTK2, RPS6KA3, ITGA4, LCK, MAPK14, MAP2K1, TNF, GSK3B, ELMO2More
Astemizolehsa05140Leishmaniasis6.15E-0813P13612, O75015, P14598, P11215, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, NCF4More
Astemizolehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Astemizolehsa05144Malaria1.80E-075P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Astemizolehsa05146Amoebiasis1.34E-1213P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Astemizolehsa05150Staphylococcus aureus infection2.52E-0613P09871, P0C0L4, P21730, P21462, O75015, P13765, P13646, Q14532, P16109, P59665, P59666, P12838, P49913C1S, C4A, C5AR1, FPR1, FCGR3B, HLA-DOB, KRT13, KRT32, SELP, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Astemizolehsa05152Tuberculosis6.23E-043P04049, P0DP23, P31751RAF1, CALM1, AKT2More
Astemizolehsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Astemizolehsa05161Hepatitis B5.33E-034P04049, Q99941, P18848, P27348RAF1, CREBL1, ATF4, YWHAQMore
Astemizolehsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Astemizolehsa05163Human cytomegalovirus infection2.54E-1125P31751, P04049, P01375, P25963, P62873, P63218, P50151, Q14643, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P04637, O00463, P30101, P01568AKT2, RAF1, TNF, NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5, PDIA3, IFNA21More
Astemizolehsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Astemizolehsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Astemizolehsa05167Kaposi sarcoma-associated herpesvirus infection1.04E-1016P01568, P31751, P42224, P25963, P40189, P01889, P10321, P62873, P63218, P50151, P19174, P04049, P07948, Q29983, P04141, P0DP23IFNA21, AKT2, STAT1, NFKBIA, IL6ST, HLA-B, HLA-C, GNB1, GNG5, GNG10, PLCG1, RAF1, LYN, MICA, CSF2, CALM1More
Astemizolehsa05168Herpes simplex virus 1 infection1.80E-0724O00463, O60603, P25963, P01568, Q05823, Q9GZY0, P42224, Q07955, Q01130, P84103, Q13243, Q16629, Q13489, P30101, Q13398, Q9NR11, Q9HCX3, P17097, Q03923, P52738, O75820, Q9NZL3, Q9UDV6, P10415TRAF5, TLR2, NFKBIA, IFNA21, RNASEL, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS3, SFRS5, SFRS7, BIRC3, PDIA3, ZNF211, ZNF302, ZNF304, ZNF7, ZNF85, ZNF140, ZNF189, ZNF224, ZNF212, BCL2More
Astemizolehsa05169Epstein-Barr virus infection9.52E-0616P13765, P01106, Q13547, O00463, P42338, P07948, P01889, P10321, Q13761, P24522, O75293, P01375, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, PIK3CB, LYN, HLA-B, HLA-C, RUNX3, GADD45A, GADD45B, TNF, OAS2, CD3E, CD3G, CD247More
Astemizolehsa05170Human immunodeficiency virus 1 infection6.77E-0819P31751, P04049, Q02750, P01889, P10321, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P30101, P01568, P25963, Q13315, P19174, P23528, Q9NQU5AKT2, RAF1, MAP2K1, HLA-B, HLA-C, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PDIA3, IFNA21, NFKBIA, ATM, PLCG1, CFL1, PAK6More
Astemizolehsa05171Coronavirus disease - COVID-191.14E-0722P01584, P25963, P42224, P01568, P23396, P62753, P62249, P40429, P62906, P36578, P27635, Q07020, P62888, P46776, P61927, P61513, P05386, P62829, P40189, P04141, P19174, P17252IL1B, NFKBIA, STAT1, IFNA21, RPS3, RPS6, RPS16, RPL13A, RPL10A, RPL4, RPL10, RPL18, RPL30, RPL27A, RPL37, RPL37A, RPLP1, RPL23, IL6ST, CSF2, PLCG1, PRKCAMore
Astemizolehsa05200Pathways in cancer2.53E-0932Q13751, P42338, P08238, P42224, P25963, P19174, P17252, P43246, P84022, Q13485, P20585, Q13547, P14923, P30281, Q13489, P98170, P49767, Q12778, P31751, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, P78417, O75293, P0DP23, P01568, P14784, P40189, P01042LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, PRKCA, MSH2, SMAD3, SMAD4, MSH3, HDAC1, JUP, CCND3, BIRC3, BIRC4, VEGFC, FOXO1, AKT2, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6ST, KNG1More
Astemizolehsa05202Transcriptional misregulation in cancer2.30E-0819Q12778, Q13315, P41732, P14780, P27930, Q15744, Q16548, Q13077, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, ATM, TSPAN7, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Astemizolehsa05203Viral carcinogenesis5.56E-0510Q99941, P18848, P27348, Q15283, P06396, P01889, P10321, P61978, P62807, O60814CREBL1, ATF4, YWHAQ, RASA2, GSN, HLA-B, HLA-C, HNRPK, HIST1H2BC, H2BC12More
Astemizolehsa05204Chemical carcinogenesis1.09E-033P09211, P78417, P11712GSTP1, GSTO1, CYP2C9More
Astemizolehsa05205Proteoglycans in cancer3.95E-0411Q12955, P04049, Q14247, P14780, P17252, P01375, P08069, P23588, Q13635, P22694, P08962ANK3, RAF1, CTTN, MMP9, PRKCA, TNF, IGF1R, EIF4B, PTCH1, PRKACB, CD63More
Astemizolehsa05206MicroRNAs in cancer6.19E-047P15311, P21860, P61978, P46531, P63279, P22105, P04049VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB, RAF1More
Astemizolehsa05210Colorectal cancer7.91E-035P84022, Q13485, P43246, P04049, O75293SMAD3, SMAD4, MSH2, RAF1, GADD45BMore
Astemizolehsa05211Renal cell carcinoma1.29E-032P31751, P04049AKT2, RAF1More
Astemizolehsa05212Pancreatic cancer2.11E-069P42338, P31751, P04049, Q15311, P23458, P42224, P84022, Q13485, O75293PIK3CB, AKT2, RAF1, RALBP1, JAK1, STAT1, SMAD3, SMAD4, GADD45BMore
Astemizolehsa05213Endometrial cancer8.16E-042P31751, P04049AKT2, RAF1More
Astemizolehsa05214Glioma8.49E-088P08069, P0DP23, Q16566, P17252, P04049, P31751, P19174, O75293IGF1R, CALM1, CAMK4, PRKCA, RAF1, AKT2, PLCG1, GADD45BMore
Astemizolehsa05215Prostate cancer2.89E-057P10415, Q12778, P08069, P18848, Q9NRA1, P14625, P04049BCL2, FOXO1, IGF1R, ATF4, PDGFC, HSP90B1, RAF1More
Astemizolehsa05218Melanoma5.24E-063P08069, P31751, P04049IGF1R, AKT2, RAF1More
Astemizolehsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Astemizolehsa05220Chronic myeloid leukemia4.90E-047Q13547, Q13485, P84022, P31751, P42338, P04049, O75293HDAC1, SMAD4, SMAD3, AKT2, PIK3CB, RAF1, GADD45BMore
Astemizolehsa05221Acute myeloid leukemia8.16E-042P31751, P04049AKT2, RAF1More
Astemizolehsa05222Small cell lung cancer6.74E-046P31751, Q16787, Q13751, Q13489, P98170, O75293AKT2, LAMA3, LAMB3, BIRC3, BIRC4, GADD45BMore
Astemizolehsa05223Non-small cell lung cancer3.49E-042P31751, P04049AKT2, RAF1More
Astemizolehsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Astemizolehsa05225Hepatocellular carcinoma1.65E-042P04049, P08069RAF1, IGF1RMore
Astemizolehsa05226Gastric cancer6.81E-042P04049, P31751RAF1, AKT2More
Astemizolehsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Astemizolehsa05231Choline metabolism in cancer3.58E-0610P04049, P31751, Q9NRA1, Q9Y259, P19174, P23743, P49619, Q16760, O14986, P17252RAF1, AKT2, PDGFC, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PRKCAMore
Astemizolehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.76E-0816P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P29350, P04049, P42224, O60603, P10747, Q04759, Q16539, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, RAF1, STAT1, TLR2, CD28, PRKCQ, MAPK14, CD4More
Astemizolehsa05310Asthma1.77E-074P13765, P29965, P12724, P01375HLA-DOB, CD40LG, RNASE3, TNFMore
Astemizolehsa05320Autoimmune thyroid disease5.49E-044P13765, P29965, P01889, P10321HLA-DOB, CD40LG, HLA-B, HLA-CMore
Astemizolehsa05321Inflammatory bowel disease5.73E-137O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Astemizolehsa05322Systemic lupus erythematosus1.30E-0411O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q93077, P62807, O60814, P68431FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Astemizolehsa05323Rheumatoid arthritis2.62E-024P01375, P13765, P10747, P09341TNF, HLA-DOB, CD28, CXCL1More
Astemizolehsa05330Allograft rejection6.25E-067P01889, P10321, P13765, P29965, P48023, P10747, P01375HLA-B, HLA-C, HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Astemizolehsa05332Graft-versus-host disease4.15E-128P13765, P48023, P01889, P10321, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, HLA-B, HLA-C, CD28, TNF, KLRC1, KLRD1More
Astemizolehsa05340Primary immunodeficiency2.22E-036P01730, P01732, P11912, Q8WV28, P07766, P06239CD4, CD8A, CD79A, BLNK, CD3E, LCKMore
Astemizolehsa05410Hypertrophic cardiomyopathy1.73E-022P26012, P09493ITGB8, TPM1More
Astemizolehsa05412Arrhythmogenic right ventricular cardiomyopathy7.64E-056P54284, P14923, P15924, P08514, P26012, Q9UJU2CACNB3, JUP, DSP, ITGA2B, ITGB8, LEF1More
Astemizolehsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Astemizolehsa05415Diabetic cardiomyopathy1.66E-069P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P14780, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, MMP9, GAPDHMore
Astemizolehsa05416Viral myocarditis1.40E-034P13765, P29965, P01889, P10321HLA-DOB, CD40LG, HLA-B, HLA-CMore
Astemizolehsa05418Fluid shear stress and atherosclerosis2.26E-0610Q16539, P31751, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1More

Community members of Astemizole (SDC: 11.40)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O95259KCNH1Potassium voltageNonegated channel subfamily H member 1Reported00.04250.046500.1143
P61088UBE2NUbiquitinNoneconjugating enzyme E2 NPredicted00.11020.38250.37361.1937
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
Q07912TNK2Activated CDC42 kinase 1Predicted00.0090.347200.6988
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P21730C5AR1C5a anaphylatoxin chemotactic receptor 1Predicted10.02580.21670.53960.986
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
Q04759PRKCQProtein kinase C theta typePredicted00.04050.42440.61731.4864
Q05655PRKCDProtein kinase C delta typePredicted00.08160.41940.65441.5339
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P40306PSMB10Proteasome subunit beta typeNone10Predicted00.26880.0510.01830.2548
Q9H4A3WNK1Serine/threonineNoneprotein kinase WNK1Predicted00.17530.038600.1648
O94782USP1Ubiquitin carboxylNoneterminal hydrolase 1Predicted00.4410.08980.02130.4215
Q13370PDE3BcGMPNoneinhibited 3',5'Nonecyclic phosphodiesterase BPredicted00.09060.16140.35580.7239
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P22694PRKACBcAMPNonedependent protein kinase catalytic subunit betaPredicted00.37370.298411.7836
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P17861XBP1XNoneboxNonebinding protein 1Predicted00.29140.06510.46080.7367
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
Q15746MYLKMyosin light chain kinase, smooth musclePredicted00.04010.31160.42981.0731
Q16566CAMK4Calcium/calmodulinNonedependent protein kinase type IVPredicted00.07180.24410.61761.1417
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P26358DNMT1DNAPredicted00.34040.28090.26590.998
Q96KQ7EHMT2HistoneNonelysine NNonemethyltransferase EHMT2Predicted00.07280.21650.29090.7603
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q8IVH8MAP4K3MitogenNoneactivated protein kinase kinase kinase kinase 3Predicted00.38330.26730.14870.875
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
Q96RR4CAMKK2Calcium/calmodulinNonedependent protein kinase kinase 2Predicted00.36280.34060.46511.3277
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P25116F2RProteinaseNoneactivated receptor 1Predicted10.20380.31960.51361.2547
P09211GSTP1Glutathione SNonetransferase PPredicted00.32040.35230.45661.3213
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
P14625HSP90B1EndoplasminPredicted00.23360.14970.53840.9546
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
O00141SGKSerine/threonineNoneprotein kinase Sgk1Predicted00.24130.30370.30591.034
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
O75381PEX14Peroxisomal membrane protein PEX14Predicted00.19070.09950.10970.4039
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
P21860ERBB3Receptor tyrosineNoneprotein kinase erbBNone3Predicted00.1260.27290.47881.0876
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)