PharmaCoNets of Ascorbic-acid (SPCN: 7.88 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ascorbic-acidhsa00140Steroid hormone biosynthesis4.77E-021P42330AKR1C3More
Ascorbic-acidhsa00500Starch and sucrose metabolism2.67E-021P35573AGLMore
Ascorbic-acidhsa00561Glycerolipid metabolism3.43E-022P14550, Q86XP1AKR1A1, DGKHMore
Ascorbic-acidhsa00565Ether lipid metabolism3.87E-032Q9Y6K0, Q8N661CEPT1, TMEM86BMore
Ascorbic-acidhsa00630Glyoxylate and dicarboxylate metabolism4.29E-032P40925, P15104MDH1, GLULMore
Ascorbic-acidhsa00983Drug metabolism - other enzymes2.14E-022P20839, Q16772IMPDH1, GSTA3More
Ascorbic-acidhsa03015mRNA surveillance pathway2.21E-024O60942, O43148, P61326, P52298RNGTT, RNMT, MAGOH, NCBP2More
Ascorbic-acidhsa03040Spliceosome1.02E-038Q14562, O43143, O60508, P52298, Q07955, Q01130, Q13243, P61326DHX8, DHX15, CDC40, NCBP2, SFRS1, SFRS2, SFRS5, MAGOHMore
Ascorbic-acidhsa03460Fanconi anemia pathway4.94E-022Q9BXW9, P07992FANCD2, ERCC1More
Ascorbic-acidhsa04010MAPK signaling pathway1.67E-037P22694, Q15283, P21860, Q9H2K8, O43283, Q12933, O14944PRKACB, RASA2, ERBB3, TAOK3, MAP3K13, TRAF2, EREGMore
Ascorbic-acidhsa04024cAMP signaling pathway4.38E-024P42338, P0DP23, Q13370, Q13009PIK3CB, CALM1, PDE3B, TIAM1More
Ascorbic-acidhsa04070Phosphatidylinositol signaling system4.86E-023P0DP23, P42338, P27987CALM1, PIK3CB, ITPKBMore
Ascorbic-acidhsa04144Endocytosis4.10E-023O75351, P62491, Q14161VPS4B, RAB11A, GIT2More
Ascorbic-acidhsa04145Phagosome1.90E-036P63261, Q15080, P14598, Q13509, Q13488, O60603ACTG1, NCF4, NCF1, TUBB3, TCIRG1, TLR2More
Ascorbic-acidhsa04330Notch signaling pathway3.43E-022Q92542, P49768NCSTN, PSEN1More
Ascorbic-acidhsa04360Axon guidance1.71E-024P20827, O95631, P42338, P23528EFNA1, NTN1, PIK3CB, CFL1More
Ascorbic-acidhsa04390Hippo signaling pathway4.16E-024P63261, P04628, O43623, Q13489ACTG1, WNT1, SNAI2, BIRC3More
Ascorbic-acidhsa04612Antigen processing and presentation7.51E-044P26715, P26717, Q07444, Q13241KLRC1, KLRC2, KLRC3, KLRD1More
Ascorbic-acidhsa04622RIG-I-like receptor signaling pathway1.12E-022Q12933, P10145TRAF2, IL8More
Ascorbic-acidhsa04623Cytosolic DNA-sensing pathway1.63E-022P01568, P25963IFNA21, NFKBIAMore
Ascorbic-acidhsa04650Natural killer cell mediated cytotoxicity1.61E-034Q13241, P26717, Q07444, P26715KLRD1, KLRC2, KLRC3, KLRC1More
Ascorbic-acidhsa04659Th17 cell differentiation4.38E-024P42224, P14784, P40189, P08238STAT1, IL2RB, IL6ST, HSP90AB1More
Ascorbic-acidhsa04666Fc gamma R-mediated phagocytosis3.08E-023P42338, P23528, P14598PIK3CB, CFL1, NCF1More
Ascorbic-acidhsa04742Taste transduction4.77E-021P22694PRKACBMore
Ascorbic-acidhsa04913Ovarian steroidogenesis3.22E-032P42330, P22694AKR1C3, PRKACBMore
Ascorbic-acidhsa04914Progesterone-mediated oocyte maturation3.92E-023P42338, Q13370, P08238PIK3CB, PDE3B, HSP90AB1More
Ascorbic-acidhsa04924Renin secretion3.77E-022Q13370, P0DP23PDE3B, CALM1More
Ascorbic-acidhsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Ascorbic-acidhsa05132Salmonella infection7.77E-037P25963, P63261, Q13489, O75369, O60603, Q13561, Q13509NFKBIA, ACTG1, BIRC3, FLNB, TLR2, DCTN2, TUBB3More
Ascorbic-acidhsa05140Leishmaniasis2.21E-024P14598, O60603, P25963, Q15080NCF1, TLR2, NFKBIA, NCF4More
Ascorbic-acidhsa05168Herpes simplex virus 1 infection1.15E-028P42224, Q07955, Q01130, Q13243, P42338, Q13398, Q03923, Q9UDV6STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF211, ZNF85, ZNF212More
Ascorbic-acidhsa05200Pathways in cancer3.92E-029P42338, P08238, P42224, P43246, P14923, O75293, P0DP23, P14784, P40189PIK3CB, HSP90AB1, STAT1, MSH2, JUP, GADD45B, CALM1, IL2RB, IL6STMore
Ascorbic-acidhsa05202Transcriptional misregulation in cancer1.77E-024Q92570, O94812, P58340, P10145NR4A3, BAIAP3, MLF1, IL8More
Ascorbic-acidhsa05212Pancreatic cancer1.72E-023P42338, P42224, O75293PIK3CB, STAT1, GADD45BMore
Ascorbic-acidhsa05214Glioma1.72E-023P0DP23, P42338, O75293CALM1, PIK3CB, GADD45BMore
Ascorbic-acidhsa05332Graft-versus-host disease3.94E-043P10747, P26715, Q13241CD28, KLRC1, KLRD1More
Ascorbic-acidhsa05418Fluid shear stress and atherosclerosis3.73E-024P42338, P14598, P0DP23, P08238PIK3CB, NCF1, CALM1, HSP90AB1More

Community members of Ascorbic-acid (SDC: 1.92)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)