PharmaCoNets

PharmaCoNets of Arzoxifene (S_PCN: 150.70 )

Arzoxifene regulated-network (S_DN: 20.31)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Arzoxifene

hsa00030

Pentose phosphate pathway

1.08E-05

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Arzoxifene

hsa00190

Oxidative phosphorylation

1.45E-06

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Arzoxifene

hsa00220

Arginine biosynthesis

1.28E-03

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Arzoxifene

hsa00230

Purine metabolism

1.81E-02

P20839, Q02153

IMPDH1, GUCY1B3

Arzoxifene

hsa00250

Alanine, aspartate and glutamate metabolism

1.97E-02

P49448, P15104

GLUD2, GLUL

Arzoxifene

hsa00260

Glycine, serine and threonine metabolism

1.99E-02

P22557

ALAS2

Arzoxifene

hsa00310

Lysine degradation

2.59E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Arzoxifene

hsa00500

Starch and sucrose metabolism

2.67E-02

P35573

AGL

Arzoxifene

hsa00512

Mucin type O-glycan biosynthesis

4.86E-02

O95395, Q9NY28

GCNT3, GALNT8

Arzoxifene

hsa00520

Amino sugar and nucleotide sugar metabolism

2.24E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Arzoxifene

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Arzoxifene

hsa00565

Ether lipid metabolism

3.94E-02

Q8N661

TMEM86B

Arzoxifene

hsa00630

Glyoxylate and dicarboxylate metabolism

9.21E-03

P40925, P15104

MDH1, GLUL

Arzoxifene

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Arzoxifene

hsa00830

Retinol metabolism

3.93E-02

P00352, Q9BPW9, O75911

ALDH1A1, DHRS9, DHRS3

Arzoxifene

hsa00860

Porphyrin and chlorophyll metabolism

1.69E-02

P36551, P30043

CPOX, BLVRB

Arzoxifene

hsa00910

Nitrogen metabolism

1.97E-02

P15104, P49448

GLUL, GLUD2

Arzoxifene

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Arzoxifene

hsa01230

Biosynthesis of amino acids

2.22E-03

P51854, P60891, Q99707, P37837

TKTL1, PRPS1, MTR, TALDO1

Arzoxifene

hsa01240

Biosynthesis of cofactors

2.52E-02

Q9BQB6, P14550

VKORC1, AKR1A1

Arzoxifene

hsa02010

ABC transporters

1.98E-03

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Arzoxifene

hsa03008

Ribosome biogenesis in eukaryotes

1.88E-02

O14980, O60832, Q9BVP2

XPO1, DKC1, GNL3

Arzoxifene

hsa03013

RNA transport

2.48E-05

O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, P23588, Q9Y6A5

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, EIF4B, TACC3

Arzoxifene

hsa03020

RNA polymerase

3.00E-02

P30876, P24928, P62487

POLR2B, POLR2A, POLR2G

Arzoxifene

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Arzoxifene

hsa03040

Spliceosome

7.03E-04

Q14562, O43143, O60508, O75940, O75494, Q07955, Q01130, Q13243, P11142

DHX8, DHX15, CDC40, SMNDC1, FUSIP1, SFRS1, SFRS2, SFRS5, HSPA8

Arzoxifene

hsa03060

Protein export

4.42E-02

P37108, Q15005

SRP14, SPCS2

Arzoxifene

hsa03410

Base excision repair

2.52E-02

P49005, P29372

POLD2, MPG

Arzoxifene

hsa04014

Ras signaling pathway

4.62E-04

P20827, Q9NRA1, P49767, Q13009, P17252, P0DP23, P62873, P63218, P50151, P19174

EFNA1, PDGFC, VEGFC, TIAM1, PRKCA, CALM1, GNB1, GNG5, GNG10, PLCG1

Arzoxifene

hsa04015

Rap1 signaling pathway

4.58E-02

P20827, Q9NRA1, P49767, P0DP23, P17252, P19174

EFNA1, PDGFC, VEGFC, CALM1, PRKCA, PLCG1

Arzoxifene

hsa04020

Calcium signaling pathway

2.01E-02

P17252, P19174, P0DP23, P20020, Q9NRA1, P49767

PRKCA, PLCG1, CALM1, ATP2B1, PDGFC, VEGFC

Arzoxifene

hsa04060

Cytokine-cytokine receptor interaction

5.34E-03

P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730

IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4

Arzoxifene

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.70E-03

P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784

CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB

Arzoxifene

hsa04062

Chemokine signaling pathway

2.97E-06

P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q08881, Q13009, P14598, P42224, P25963

CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ITK, TIAM1, NCF1, STAT1, NFKBIA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.746
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818

Arzoxifene

hsa04064

NF-kappa B signaling pathway

4.28E-05

O00463, P14778, P01584, P19174, Q04759, P07948, P06239, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7

TRAF5, IL1R1, IL1B, PLCG1, PRKCQ, LYN, LCK, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLD

Arzoxifene

hsa04070

Phosphatidylinositol signaling system

3.27E-03

P19174, P0DP23, P23743, P27987, P17252

PLCG1, CALM1, DGKA, ITPKB, PRKCA

Arzoxifene

hsa04071

Sphingolipid signaling pathway

1.19E-02

P21453, Q9H228, P01375, Q13362

S1PR1, EDG8, TNF, PPP2R5C

Arzoxifene

hsa04072

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Arzoxifene

hsa04080

Neuroactive ligand-receptor interaction

1.97E-02

P28472, P21453, Q9H228, P21730, P07550

GABRB3, S1PR1, EDG8, C5AR1, ADRB2

Arzoxifene

hsa04120

Ubiquitin mediated proteolysis

2.51E-03

Q14145, Q13042, P62837, Q15751, O95071, P0CG47

KEAP1, CDC16, UBE2D2, HERC1, UBR5, UBB

Arzoxifene

hsa04136

Autophagy - other

5.92E-03

O94817, Q9H1Y0

ATG12, ATG5

Arzoxifene

hsa04137

Mitophagy - animal

9.52E-03

Q07817, P0CG47

BCL2L1, UBB

Arzoxifene

hsa04141

Protein processing in endoplasmic reticulum

8.60E-03

P30101, P60604, P11142, P08238, Q9H173, Q9UNL2

PDIA3, UBE2G2, HSPA8, HSP90AB1, SIL1, SSR3

Arzoxifene

hsa04142

Lysosome

1.46E-02

P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916

HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2

Arzoxifene

hsa04144

Endocytosis

1.67E-02

P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4

HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12

Arzoxifene

hsa04145

Phagosome

6.82E-06

P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765

ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Arzoxifene

hsa04151

PI3K-Akt signaling pathway

3.96E-02

P43657, P09603, Q9GZP0, P63218, P50151, P13612, O15335, Q13751

P2RY5, CSF1, PDGFD, GNG5, GNG10, ITGA4, CHAD, LAMB3

Arzoxifene

hsa04213

Longevity regulating pathway - multiple species

2.70E-03

P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547

PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1

Arzoxifene

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Arzoxifene

hsa04217

Necroptosis

1.16E-05

P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752

TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPID

Arzoxifene

hsa04261

Adrenergic signaling in cardiomyocytes

2.95E-02

P07550, P22694, P18848, Q13362

ADRB2, PRKACB, ATF4, PPP2R5C

Arzoxifene

hsa04270

Vascular smooth muscle contraction

6.96E-03

P0DP23, Q08828, P51828, P35579, P35749, P35318

CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM

Arzoxifene

hsa04360

Axon guidance

2.29E-02

P16333, P20827, O95631, P17252, P19174

NCK1, EFNA1, NTN1, PRKCA, PLCG1

Arzoxifene

hsa04371

Apelin signaling pathway

7.95E-04

P62873, P63218, P50151, Q13370, Q14344, P84022, P0DP23

GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD3, CALM1

Arzoxifene

hsa04390

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Arzoxifene

hsa04512

ECM-receptor interaction

4.41E-02

Q13751, P13612, O15335

LAMB3, ITGA4, CHAD

Arzoxifene

hsa04540

Gap junction

4.54E-04

P17252, Q13509, P68371, Q71U36, Q9NRA1

PRKCA, TUBB3, TUBB2C, TUBA1A, PDGFC

Arzoxifene

hsa04610

Complement and coagulation cascades

4.27E-08

P00734, P0C0L4

F2, C4A

Arzoxifene

hsa04612

Antigen processing and presentation

8.00E-06

P13765, P48382, P01730, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, CD4, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.73
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P48382	RFX5	DNA-binding protein RFX5	-0.738
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.856
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.741
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.816
P07550	ADRB2	Beta-2 adrenergic receptor	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755

Arzoxifene

hsa04613

Neutrophil extracellular trap formation

3.82E-03

O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, Q93077, P68431, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539

TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Arzoxifene

hsa04623

Cytosolic DNA-sensing pathway

2.44E-06

P01584, P01568, P25963, Q8NHW4

IL1B, IFNA21, NFKBIA, CCL4L2

Arzoxifene

hsa04625

C-type lectin receptor signaling pathway

4.80E-02

Q9ULY5, P20749, Q14643, P01375, Q13191, Q16539

CLEC4E, BCL3, ITPR1, TNF, CBLB, MAPK14

Arzoxifene

hsa04640

Hematopoietic cell lineage

1.71E-06

P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375

ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13612	ITGA4	Integrin alpha-4	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.762
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.924
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P15144	ANPEP	Aminopeptidase N	0.879
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P11836	MS4A1	B-lymphocyte antigen CD20	-0.705
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.816
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.73
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774

Arzoxifene

hsa04650

Natural killer cell mediated cytotoxicity

1.13E-08

P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715

PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P78314	SH3BP2	SH3 domain-binding protein 2	0.809
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.81
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.77
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.856
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.879
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.893
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Arzoxifene

hsa04657

IL-17 signaling pathway

2.27E-04

P25963, P08238, O00463, Q07955, Q16539, P49841, P09341, P19875, P14780, P04141, P80188, P01375, P06702

NFKBIA, HSP90AB1, TRAF5, SFRS1, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, CSF2, LCN2, TNF, S100A9

Arzoxifene

hsa04658

Th1 and Th2 cell differentiation

3.76E-11

Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q04759	PRKCQ	Protein kinase C theta type	-0.762
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.77
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.833
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.768
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.767
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q9UL17	TBX21	T-box transcription factor TBX21	-0.861
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884

Arzoxifene

hsa04659

Th17 cell differentiation

1.23E-10

P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q04759	PRKCQ	Protein kinase C theta type	-0.762
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.833
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.762
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q9UL17	TBX21	T-box transcription factor TBX21	-0.861
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.767
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.77

Arzoxifene

hsa04660

T cell receptor signaling pathway

6.98E-08

P01375, P04141, P25963, Q04759, P42338, P10747, O95267, Q08881, P19174, P16333, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P29350, Q16539, P49841

TNF, CSF2, NFKBIA, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, PTPN6, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P04141	CSF2	Granulocyte-macrophage colony-stimulating factor	0.757
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.739
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q04759	PRKCQ	Protein kinase C theta type	-0.762
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.758
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.812
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.739
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P16333	NCK1	Cytoplasmic protein NCK1	-0.703
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.77
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.816
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.816
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.797
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.833
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.781

Arzoxifene

hsa04664

Fc epsilon RI signaling pathway

6.97E-03

P04141, P07948, P19174, P09917

CSF2, LYN, PLCG1, ALOX5

Arzoxifene

hsa04666

Fc gamma R-mediated phagocytosis

2.42E-02

P23528, P06396, O14494, P14598, P17252

CFL1, GSN, PLPP1, NCF1, PRKCA

Arzoxifene

hsa04668

TNF signaling pathway

3.55E-02

P01375, P18848, P19875, P14780

TNF, ATF4, CXCL2, MMP9

Arzoxifene

hsa04672

Intestinal immune network for IgA production

1.62E-02

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Arzoxifene

hsa04713

Circadian entrainment

1.85E-03

P0DP23, P17252, P62873, P63218, P50151, O15055

CALM1, PRKCA, GNB1, GNG5, GNG10, PER2

Arzoxifene

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Arzoxifene

hsa04721

Synaptic vesicle cycle

3.15E-02

Q13488, P31645

TCIRG1, SLC6A4

Arzoxifene

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Arzoxifene

hsa04724

Glutamatergic synapse

3.88E-04

O15399, P62873, P63218, P50151, P15104

GRIN2D, GNB1, GNG5, GNG10, GLUL

Arzoxifene

hsa04726

Serotonergic synapse

3.80E-02

P62873, P63218, P50151, P09917

GNB1, GNG5, GNG10, ALOX5

Arzoxifene

hsa04727

GABAergic synapse

2.40E-04

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Arzoxifene

hsa04730

Long-term depression

3.34E-03

Q14344, P07948

GNA13, LYN

Arzoxifene

hsa04744

Phototransduction

3.56E-06

P62873, P0DP23

GNB1, CALM1

Arzoxifene

hsa04750

Inflammatory mediator regulation of TRP channels

7.85E-04

P14778, P01584, Q08828, P51828, P19174, P42338, P24723, Q04759, P0DP23

IL1R1, IL1B, ADCY1, ADCY7, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1

Arzoxifene

hsa04912

GnRH signaling pathway

4.72E-02

Q16539, Q9Y6R4, Q14643, P22694

MAPK14, MAP3K4, ITPR1, PRKACB

Arzoxifene

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Arzoxifene

hsa04915

Estrogen signaling pathway

3.17E-02

Q08828, P51828, P0DMV8, P0DP23, Q15788

ADCY1, ADCY7, HSPA1A, CALM1, NCOA1

Arzoxifene

hsa04916

Melanogenesis

4.80E-02

P0DP23, Q9UJU2, P17252, P04628

CALM1, LEF1, PRKCA, WNT1

Arzoxifene

hsa04920

Adipocytokine signaling pathway

4.72E-02

P33121, Q04759, Q9Y4H2, P01375

ACSL1, PRKCQ, IRS2, TNF

Arzoxifene

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Arzoxifene

hsa04924

Renin secretion

4.04E-02

P22694, P07550

PRKACB, ADRB2

Arzoxifene

hsa04926

Relaxin signaling pathway

2.41E-02

P18848, P22694, P14780, P30679

ATF4, PRKACB, MMP9, GNA15

Arzoxifene

hsa04927

Cortisol synthesis and secretion

2.54E-02

P18848, P22694

ATF4, PRKACB

Arzoxifene

hsa04932

Non-alcoholic fatty liver disease

7.01E-05

P01375, P49841, O43521, P48023, O75460, P01584, P13073, P12074, Q16718, O95298, O14521

TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHD

Arzoxifene

hsa04933

AGE-RAGE signaling pathway in diabetic complications

8.48E-04

P84022, Q13485, P42224, P10415, Q12778, P49767, P17252, P19174

SMAD3, SMAD4, STAT1, BCL2, FOXO1, VEGFC, PRKCA, PLCG1

Arzoxifene

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Arzoxifene

hsa04964

Proximal tubule bicarbonate reclamation

4.48E-02

P00918

CA2

Arzoxifene

hsa04966

Collecting duct acid secretion

4.48E-02

P00918

CA2

Arzoxifene

hsa04970

Salivary secretion

2.43E-03

P07550, Q08828, P51828, P22694, P0DP23, P49913

ADRB2, ADCY1, ADCY7, PRKACB, CALM1, CAMP

Arzoxifene

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Arzoxifene

hsa04975

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Arzoxifene

hsa04976

Bile secretion

3.14E-03

O43315, Q08828, P51828, P08183, Q14032

AQP9, ADCY1, ADCY7, ABCB1, BAAT

Arzoxifene

hsa05010

Alzheimer disease

4.39E-02

O15399, Q9NZJ5, Q13564, Q71U36, P09603, P21796

GRIN2D, EIF2AK3, APPBP1, TUBA1A, CSF1, VDAC1

Arzoxifene

hsa05012

Parkinson disease

1.62E-03

Q16718, O14521, P60604, P19174, P0DP23, Q71U36, Q13509, P68371

NDUFA5, SDHD, UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2C

Arzoxifene

hsa05016

Huntington disease

2.46E-02

O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232

NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12

Arzoxifene

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Arzoxifene

hsa05022

Pathways of neurodegeneration - multiple diseases

1.14E-03

Q13509, P68371, P49841, Q16718, O14521, Q13561, P19174, P17252, Q16539, Q08752, P0DP23

TUBB3, TUBB2C, GSK3B, NDUFA5, SDHD, DCTN2, PLCG1, PRKCA, MAPK14, PPID, CALM1

Arzoxifene

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

Arzoxifene

hsa05032

Morphine addiction

7.62E-04

P62873, P63218, P50151, Q13370, Q07343, P43250

GNB1, GNG5, GNG10, PDE3B, PDE4B, GRK6

Arzoxifene

hsa05110

Vibrio cholerae infection

1.98E-02

Q13488, P17252, P19174

TCIRG1, PRKCA, PLCG1

Arzoxifene

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

7.88E-05

P25963, Q13488, P09341, P19875, P19174, P25024, P25025, P07948

NFKBIA, TCIRG1, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN

Arzoxifene

hsa05130

Pathogenic Escherichia coli infection

3.19E-02

Q71U36, P16333, Q13509, P68371, Q14344, P25963

TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIA

Arzoxifene

hsa05132

Salmonella infection

1.96E-05

P51617, P25963, P08238, Q9UJU2, Q13489, P10415, P04406, O75369, O60603, Q9BQS8, Q13561, Q71U36, Q13509, P68371, P49754

IRAK1, NFKBIA, HSP90AB1, LEF1, BIRC3, BCL2, GAPDH, FLNB, TLR2, FYCO1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10415	BCL2	Apoptosis regulator Bcl-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.807
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.739
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.826
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P10415	BCL2	Apoptosis regulator Bcl-2	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.908
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P10415	BCL2	Apoptosis regulator Bcl-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.848
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P10415	BCL2	Apoptosis regulator Bcl-2	P10415	BCL2	Apoptosis regulator Bcl-2	1
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	-0.76
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O75369	FLNB	Filamin-B	-0.715
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75369	FLNB	Filamin-B	0.706
P10415	BCL2	Apoptosis regulator Bcl-2	O75369	FLNB	Filamin-B	-0.762
P10415	BCL2	Apoptosis regulator Bcl-2	O60603	TLR2	Toll-like receptor 2	-0.884
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P10415	BCL2	Apoptosis regulator Bcl-2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.929
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13561	DCTN2	Dynactin subunit 2	-0.744
P10415	BCL2	Apoptosis regulator Bcl-2	Q13561	DCTN2	Dynactin subunit 2	-0.843
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.866
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13509	TUBB3	Tubulin beta-3 chain	-0.808
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13509	TUBB3	Tubulin beta-3 chain	0.789
P10415	BCL2	Apoptosis regulator Bcl-2	Q13509	TUBB3	Tubulin beta-3 chain	-0.809
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P68371	TUBB2C	Tubulin beta-4B chain	-0.721
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P68371	TUBB2C	Tubulin beta-4B chain	0.741
P10415	BCL2	Apoptosis regulator Bcl-2	P68371	TUBB2C	Tubulin beta-4B chain	-0.766
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	-0.718
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.728

Arzoxifene

hsa05133

Pertussis

2.95E-04

P0DP23, P0C0L4

CALM1, C4A

Arzoxifene

hsa05134

Legionellosis

1.05E-04

P01584, P25963, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875

IL1B, NFKBIA, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2

Arzoxifene

hsa05140

Leishmaniasis

5.38E-06

P13612, O75015, P14598, P11215, P42224, P13765, O60603, P25963, P01375, P29350, Q16539, Q15080

ITGA4, FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MAPK14, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13612	ITGA4	Integrin alpha-4	-0.771
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.893
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P14598	NCF1	Neutrophil cytosol factor 1	-0.867
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11215	ITGAM	Integrin alpha-M	-0.78
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.912
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.73
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O60603	TLR2	Toll-like receptor 2	0.867
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.739
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.797
P09960	LTA4H	Leukotriene A-4 hydrolase	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	0.808
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.833
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q15080	NCF4	Neutrophil cytosol factor 4	-0.723
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.764

Arzoxifene

hsa05143

African trypanosomiasis

3.01E-03

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Arzoxifene

hsa05144

Malaria

9.55E-04

P60033, O60603, P01375, P35443, P26718

CD81, TLR2, TNF, THBS4, KLRK1

Arzoxifene

hsa05145

Toxoplasmosis

2.78E-02

P25963, P10415, Q13489

NFKBIA, BCL2, BIRC3

Arzoxifene

hsa05146

Amoebiasis

3.06E-08

P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311

CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P09341	CXCL1	Growth-regulated alpha protein	0.781
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P07550	ADRB2	Beta-2 adrenergic receptor	P19875	CXCL2	C-X-C motif chemokine 2	-0.83
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.762
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.924
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O60603	TLR2	Toll-like receptor 2	0.867
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P05089	ARG1	Arginase-1	0.811
P07550	ADRB2	Beta-2 adrenergic receptor	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	-0.8
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.779
P07550	ADRB2	Beta-2 adrenergic receptor	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P08311	CTSG	Cathepsin G	0.709

Arzoxifene

hsa05150

Staphylococcus aureus infection

1.31E-02

P0C0L4, P13646

C4A, KRT13

Arzoxifene

hsa05152

Tuberculosis

5.68E-03

Q13488, P0DP23, P48382, O60603, P10415, P13765, P01568, Q9UDY8, P51617

TCIRG1, CALM1, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1

Arzoxifene

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Arzoxifene

hsa05161

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Arzoxifene

hsa05162

Measles

3.18E-02

P23458, P0DMV8, P01584, Q9NP90

JAK1, HSPA1A, IL1B, RAB9B

Arzoxifene

hsa05163

Human cytomegalovirus infection

3.02E-04

P25963, P62873, P63218, P50151, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P01584, Q13651, P30101, P01568

NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, IL10RA, PDIA3, IFNA21

Arzoxifene

hsa05167

Kaposi sarcoma-associated herpesvirus infection

2.43E-06

P01568, P42224, P25963, P40189, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23

IFNA21, STAT1, NFKBIA, IL6ST, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P01568	IFNA21	Interferon alpha-21	0.729
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.912
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.739
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P40189	IL6ST	Interleukin-6 receptor subunit beta	-0.746
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.833
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.739
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P04141	CSF2	Granulocyte-macrophage colony-stimulating factor	0.757
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P04141	CSF2	Granulocyte-macrophage colony-stimulating factor	-0.79
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P0DP23	CALM1	Calmodulin-1	-0.761
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775

Arzoxifene

hsa05168

Herpes simplex virus 1 infection

8.20E-06

P25963, P01568, Q05823, Q9GZY0, P42224, Q07955, Q01130, Q13243, Q13489, P30101, Q13398, Q9HCX3, Q03923, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, RNASEL, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, ZNF211, ZNF304, ZNF85, ZNF140, ZNF189, ZNF212

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.739
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P01568	IFNA21	Interferon alpha-21	0.729
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P09960	LTA4H	Leukotriene A-4 hydrolase	Q05823	RNASEL	2-5A-dependent ribonuclease	0.752
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	0.704
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.912
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.776
P09960	LTA4H	Leukotriene A-4 hydrolase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.732
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.827
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.758
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.783
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.87
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.819
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.943
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13398	ZNF211	Zinc finger protein 211	-0.759
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13398	ZNF211	Zinc finger protein 211	0.729
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13398	ZNF211	Zinc finger protein 211	0.849
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9HCX3	ZNF304	Zinc finger protein 304	-0.746
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q03923	ZNF85	Zinc finger protein 85	0.79
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P52738	ZNF140	Zinc finger protein 140	0.717
P09960	LTA4H	Leukotriene A-4 hydrolase	P52738	ZNF140	Zinc finger protein 140	-0.724
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O75820	ZNF189	Zinc finger protein 189	0.715
P09960	LTA4H	Leukotriene A-4 hydrolase	O75820	ZNF189	Zinc finger protein 189	-0.722
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75820	ZNF189	Zinc finger protein 189	-0.766
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q9UDV6	ZNF212	Zinc finger protein 212	-0.808
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9UDV6	ZNF212	Zinc finger protein 212	0.824

Arzoxifene

hsa05169

Epstein-Barr virus infection

4.84E-03

P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963

HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247

Arzoxifene

hsa05170

Human immunodeficiency virus 1 infection

2.58E-04

P62873, P63218, P50151, P0DP23, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, P19174, P23528, P10415, Q93034, Q9Y6Q5

GNB1, GNG5, GNG10, CALM1, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, PLCG1, CFL1, BCL2, CUL5, AP1M2

Arzoxifene

hsa05171

Coronavirus disease - COVID-19

1.36E-02

P25963, P42224, P01568, P40189, P04141, P19174, P17252

NFKBIA, STAT1, IFNA21, IL6ST, CSF2, PLCG1, PRKCA

Arzoxifene

hsa05200

Pathways in cancer

1.51E-04

P08238, P42224, P25963, P19174, P17252, P43246, P84022, P20585, P14923, P49767, Q12778, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784, P40189

HSP90AB1, STAT1, NFKBIA, PLCG1, PRKCA, MSH2, SMAD3, MSH3, JUP, VEGFC, FOXO1, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB, IL6ST

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.826
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.912
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.739
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.739
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P17252	PRKCA	Protein kinase C alpha type	0.832
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P43246	MSH2	DNA mismatch repair protein Msh2	-0.768
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P43246	MSH2	DNA mismatch repair protein Msh2	0.816
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P20585	MSH3	DNA mismatch repair protein Msh3	0.825
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P14923	JUP	Junction plakoglobin	0.735
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P49767	VEGFC	Vascular endothelial growth factor C	0.761
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q12778	FOXO1	Forkhead box protein O1	0.753
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.833
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.713
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.742
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P0DP23	CALM1	Calmodulin-1	-0.761
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P01568	IFNA21	Interferon alpha-21	0.729
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P40189	IL6ST	Interleukin-6 receptor subunit beta	-0.746

Arzoxifene

hsa05202

Transcriptional misregulation in cancer

3.44E-04

Q12778, Q15532, P41732, P14780, P27930, P14923, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522

FOXO1, SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10415	BCL2	Apoptosis regulator Bcl-2	Q12778	FOXO1	Forkhead box protein O1	0.794
P10415	BCL2	Apoptosis regulator Bcl-2	Q15532	SS18	Protein SSXT	0.877
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P41732	TSPAN7	Tetraspanin-7	0.703
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P14780	MMP9	Matrix metalloproteinase-9	0.942
P10415	BCL2	Apoptosis regulator Bcl-2	P14780	MMP9	Matrix metalloproteinase-9	-0.765
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.924
P10415	BCL2	Apoptosis regulator Bcl-2	P14923	JUP	Junction plakoglobin	0.861
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16548	BCL2A1	Bcl-2-related protein A1	0.913
P10415	BCL2	Apoptosis regulator Bcl-2	Q16548	BCL2A1	Bcl-2-related protein A1	-0.746
P10415	BCL2	Apoptosis regulator Bcl-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.848
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q13077	TRAF1	TNF receptor-associated factor 1	-0.712
P10415	BCL2	Apoptosis regulator Bcl-2	Q13077	TRAF1	TNF receptor-associated factor 1	0.816
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P10415	BCL2	Apoptosis regulator Bcl-2	P35226	BMI1	Polycomb complex protein BMI-1	0.78
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P10415	BCL2	Apoptosis regulator Bcl-2	P35226	BMI1	Polycomb complex protein BMI-1	0.78
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P05164	MPO	Myeloperoxidase	0.711
P10415	BCL2	Apoptosis regulator Bcl-2	P05164	MPO	Myeloperoxidase	-0.81
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P12838	DEFA4	Neutrophil defensin 4	0.767
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P08246	ELA2	Neutrophil elastase	0.703
P10415	BCL2	Apoptosis regulator Bcl-2	P08246	ELA2	Neutrophil elastase	-0.942
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.765
P10415	BCL2	Apoptosis regulator Bcl-2	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.766
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P41182	BCL6	B-cell lymphoma 6 protein	0.9
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q13547	HDAC1	Histone deacetylase 1	-0.742
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q92769	HDAC2	Histone deacetylase 2	-0.746
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P12980	LYL1	Protein lyl-1	0.782
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.801

Arzoxifene

hsa05205

Proteoglycans in cancer

1.39E-03

Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P01375, P23588, P04628, Q13635, P22694, P08962

TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, TNF, EIF4B, WNT1, PTCH1, PRKACB, CD63

Arzoxifene

hsa05210

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Arzoxifene

hsa05212

Pancreatic cancer

4.70E-03

P42224, P84022, Q13485, O75293

STAT1, SMAD3, SMAD4, GADD45B

Arzoxifene

hsa05214

Glioma

1.29E-03

P0DP23, P17252, P19174, O75293

CALM1, PRKCA, PLCG1, GADD45B

Arzoxifene

hsa05220

Chronic myeloid leukemia

1.25E-02

Q13485, P25963, P84022

SMAD4, NFKBIA, SMAD3

Arzoxifene

hsa05222

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Arzoxifene

hsa05226

Gastric cancer

2.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Arzoxifene

hsa05231

Choline metabolism in cancer

2.25E-03

Q9NRA1, Q9Y259, P19174, P23743, P17252

PDGFC, CHKB, PLCG1, DGKA, PRKCA

Arzoxifene

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

2.25E-05

P25963, P42338, P19174, P07766, P20963, P09693, P06239, P29350, P42224, P10747, Q04759, P01730

NFKBIA, PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, STAT1, CD28, PRKCQ, CD4

Arzoxifene

hsa05320

Autoimmune thyroid disease

8.64E-03

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Arzoxifene

hsa05321

Inflammatory bowel disease

1.48E-04

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Arzoxifene

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Arzoxifene

hsa05332

Graft-versus-host disease

1.02E-05

P13765, P48023, P01375, P26715, Q13241

HLA-DOB, FASLG, TNF, KLRC1, KLRD1

Arzoxifene

hsa05340

Primary immunodeficiency

2.19E-02

P01730, P01732, P07766, P06239

CD4, CD8A, CD3E, LCK

Arzoxifene

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.48E-02

P54284

CACNB3

Arzoxifene

hsa05414

Dilated cardiomyopathy

4.55E-02

P54284, P26678

CACNB3, PLN

Arzoxifene

hsa05415

Diabetic cardiomyopathy

1.87E-05

P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406

PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDH

Community members of Arzoxifene (S_DC: 7.42)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

UBE2N

UbiquitinNoneconjugating enzyme E2 N

Predicted

0.1102

0.3825

0.3736

1.1937

O75469

NR1I2

Nuclear receptor subfamily 1 group I member 2

Predicted

0.0315

0.9493

1.9143

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

Q92769

HDAC2

Histone deacetylase 2

Predicted

0.0473

0.986

3.0097

P09619

PDGFRB

PlateletNonederived growth factor receptor beta

Predicted

0.0496

0.9444

0.7408

2.6543

Q07817

BCL2L1

BclNone2Nonelike protein 1

Predicted

0.0872

0.4349

1.9134

P10415

BCL2

Apoptosis regulator BclNone2

Predicted

0.0341

0.5271

2.0714

P09960

LTA4H

Leukotriene ANone4 hydrolase

Predicted

0.277

0.9519

0.1565

2.1988

Q02763

TEK

AngiopoietinNone1 receptor

Predicted

0.3206

0.6236

0.4304

1.8379

P23458

JAK1

TyrosineNoneprotein kinase JAK1

Predicted

0.5546

0.9211

3.1195

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P08238

HSP90AB1

Heat shock protein HSP 90Nonebeta

Predicted

0.0611

0.5208

0.741

1.8131

P21730

C5AR1

C5a anaphylatoxin chemotactic receptor 1

Predicted

0.0258

0.2167

0.5396

0.986

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

Q13370

PDE3B

cGMPNoneinhibited 3',5'Nonecyclic phosphodiesterase B

Predicted

0.0906

0.1614

0.3558

0.7239

P30531

SLC6A1

SodiumNone and chlorideNonedependent GABA transporter 1

Predicted

0.0889

0.5202

0.1047

1.1894

P06239

LCK

TyrosineNoneprotein kinase Lck

Predicted

0.0576

0.7287

2.7575

P00734

Prothrombin

Predicted

0.0963

0.707

0.4977

1.9598

PharmaCoNets of Arzoxifene (SPCN: 150.70 )

Arzoxifene regulated-network (SDN: 20.31)

Community members of Arzoxifene (SDC: 7.42)

PharmaCoNets of Arzoxifene (S_PCN: 150.70 )

Arzoxifene regulated-network (S_DN: 20.31)

Community members of Arzoxifene (S_DC: 7.42)