PharmaCoNets of Armodafinil (SPCN: 22.17 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Armodafinilhsa00190Oxidative phosphorylation1.10E-033Q16718, P36542, O14521NDUFA5, ATP5C1, SDHDMore
Armodafinilhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Armodafinilhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Armodafinilhsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Armodafinilhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Armodafinilhsa00830Retinol metabolism3.15E-021P00325ADH1BMore
Armodafinilhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Armodafinilhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Armodafinilhsa00983Drug metabolism - other enzymes3.59E-023P04183, P32320, P05164TK1, CDA, MPOMore
Armodafinilhsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Armodafinilhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Armodafinilhsa03008Ribosome biogenesis in eukaryotes1.46E-024Q9NYH9, P78345, Q9BVP2, Q9GZY0UTP6, RPP38, GNL3, NXF2; NXF2BMore
Armodafinilhsa03013RNA transport2.88E-0518O14980, P52298, Q09161, O14893, P61326, Q9GZY0, Q7Z3B4, P35658, P47813, Q14152, O75822, P78345, Q14240, Q9BZI7, Q9Y6A5, Q06787, P51114, Q53GS7XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NXF2; NXF2B, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, RPP38, EIF4A2, UPF3B, TACC3, FMR1, FXR1, GLE1More
Armodafinilhsa03015mRNA surveillance pathway9.78E-036O43148, Q16537, P61326, Q9GZY0, P52298, Q53GS7RNMT, PPP2R5E, MAGOH, NXF2; NXF2B, NCBP2, GLE1More
Armodafinilhsa03020RNA polymerase1.31E-022P24928, P62487POLR2A, POLR2GMore
Armodafinilhsa03022Basal transcription factors2.97E-033P20226, O00268, Q15544TBP, TAF4, TAF11More
Armodafinilhsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Armodafinilhsa04071Sphingolipid signaling pathway3.08E-025P17252, Q16537, Q9BX95, P04637, P10415PRKCA, PPP2R5E, SGPP1, TP53, BCL2More
Armodafinilhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Armodafinilhsa04145Phagosome3.27E-049P63261, Q15080, P14598, Q13509, P68371, P05164, O60603, P35443, P13765ACTG1, NCF4, NCF1, TUBB3, TUBB2C, MPO, TLR2, THBS4, HLA-DOBMore
Armodafinilhsa04146Peroxisome4.83E-024O96011, P56589, Q9UKG9, O75521PEX11B, PEX3, CROT, ECI2More
Armodafinilhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Armodafinilhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Armodafinilhsa04540Gap junction3.53E-024P17252, Q13509, P68371, Q14643PRKCA, TUBB3, TUBB2C, ITPR1More
Armodafinilhsa04610Complement and coagulation cascades2.78E-031P0C0L4C4AMore
Armodafinilhsa04613Neutrophil extracellular trap formation3.43E-0417P17252, O60603, P05164, P08246, Q9UM07, P04908, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P21462, P63261, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1, ACTG1, AQP9, MAPK14More
Armodafinilhsa04666Fc gamma R-mediated phagocytosis9.96E-035P23528, P49006, P06396, P14598, P17252CFL1, MARCKSL1, GSN, NCF1, PRKCAMore
Armodafinilhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Armodafinilhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Armodafinilhsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Armodafinilhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Armodafinilhsa04966Collecting duct acid secretion1.68E-022P02730, P00918SLC4A1, CA2More
Armodafinilhsa04972Pancreatic secretion1.67E-035Q14643, P20020, P17252, Q08828, P62491ITPR1, ATP2B1, PRKCA, ADCY1, RAB11AMore
Armodafinilhsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Armodafinilhsa05014Amyotrophic lateral sclerosis2.72E-0210P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7More
Armodafinilhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Armodafinilhsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Armodafinilhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Armodafinilhsa05132Salmonella infection2.10E-029Q9UJU2, P63261, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371LEF1, ACTG1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Armodafinilhsa05133Pertussis4.94E-021P0C0L4C4AMore
Armodafinilhsa05140Leishmaniasis4.13E-025P14598, P13765, O60603, P49006, Q15080NCF1, HLA-DOB, TLR2, MARCKSL1, NCF4More
Armodafinilhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Armodafinilhsa05150Staphylococcus aureus infection4.02E-036P21462, O75015, Q14532, P59665, P59666, P12838FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4More
Armodafinilhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Armodafinilhsa05202Transcriptional misregulation in cancer6.80E-0312Q12778, Q15532, P41732, P14780, P14923, Q13489, O15550, P04637, P05164, P08246, Q9C0K0, P24522FOXO1, SS18, TSPAN7, MMP9, JUP, BIRC3, UTX, TP53, MPO, ELA2, BCL11B, GADD45AMore
Armodafinilhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Armodafinilhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Armodafinilhsa05205Proteoglycans in cancer2.66E-028Q14643, P63261, P04637, P14780, P17252, O60603, Q13635, P08962ITPR1, ACTG1, TP53, MMP9, PRKCA, TLR2, PTCH1, CD63More
Armodafinilhsa05216Thyroid cancer3.59E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Armodafinilhsa05217Basal cell carcinoma1.46E-024Q13635, Q9UJU2, P04637, P24522PTCH1, LEF1, TP53, GADD45AMore
Armodafinilhsa05218Melanoma1.07E-023P09619, Q9GZP0, Q02750PDGFRB, PDGFD, MAP2K1More
Armodafinilhsa05231Choline metabolism in cancer9.39E-034Q02750, P09619, Q9GZP0, O15245MAP2K1, PDGFRB, PDGFD, SLC22A1More
Armodafinilhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Armodafinilhsa05323Rheumatoid arthritis3.53E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Armodafinilhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Armodafinilhsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Armodafinilhsa05412Arrhythmogenic right ventricular cardiomyopathy3.10E-023Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Armodafinilhsa05414Dilated cardiomyopathy2.11E-024Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Armodafinilhsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Armodafinilhsa05418Fluid shear stress and atherosclerosis4.26E-026P14598, P14780, P63261, P04637, P10415, Q92974NCF1, MMP9, ACTG1, TP53, BCL2, ARHGEF2More

Community members of Armodafinil (SDC: 3.11)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q96EB6SIRT1NADNonedependent protein deacetylase sirtuinNone1Predicted10.28650.45710.57841.6358
Q13093PLA2G7PlateletNoneactivating factor acetylhydrolasePredicted00.05050.20960.15580.6001
P16083NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]Predicted00.29580.313400.7747
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)