PharmaCoNets of Argatroban (SPCN: 8.06 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Argatrobanhsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Argatrobanhsa01522Endocrine resistance4.74E-023P22694, P10415, Q13323PRKACB, BCL2, BIKMore
Argatrobanhsa04015Rap1 signaling pathway2.26E-023P25116, Q8TEU7, P08514F2R, RAPGEF6, ITGA2BMore
Argatrobanhsa04022cGMP-PKG signaling pathway1.05E-023P24844, Q8WYR1, Q15746MYL9, PIK3R5, MYLKMore
Argatrobanhsa04024cAMP signaling pathway1.40E-023P48058, P25116, P24844GRIA4, F2R, MYL9More
Argatrobanhsa04080Neuroactive ligand-receptor interaction4.90E-036P08311, Q15722, P21453, Q9H228, O00398, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, ADRB2More
Argatrobanhsa04140Autophagy - animal4.74E-023P22694, Q14643, P10415PRKACB, ITPR1, BCL2More
Argatrobanhsa04270Vascular smooth muscle contraction4.65E-022Q15746, P24844MYLK, MYL9More
Argatrobanhsa04340Hedgehog signaling pathway9.74E-033P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Argatrobanhsa04510Focal adhesion3.36E-023P08514, Q15746, P24844ITGA2B, MYLK, MYL9More
Argatrobanhsa04512ECM-receptor interaction2.44E-022P07359, P08514GP1BA, ITGA2BMore
Argatrobanhsa04514Cell adhesion molecules4.65E-022P16109, O00501SELP, CLDN5More
Argatrobanhsa04530Tight junction7.42E-044Q8TEU7, O00501, Q14247, P24844RAPGEF6, CLDN5, CTTN, MYL9More
Argatrobanhsa04540Gap junction2.86E-023P22694, P68371, Q14643PRKACB, TUBB2C, ITPR1More
Argatrobanhsa04610Complement and coagulation cascades9.44E-044P25116, P00734, P0C0L4, P10909F2R, F2, C4A, CLUMore
Argatrobanhsa04611Platelet activation1.59E-055P25116, P08514, Q15746, Q8WYR1, P07359F2R, ITGA2B, MYLK, PIK3R5, GP1BAMore
Argatrobanhsa04724Glutamatergic synapse2.94E-022P48058, Q9NSB8GRIA4, HOMER2More
Argatrobanhsa04725Cholinergic synapse3.74E-023P22694, Q14643, P10415PRKACB, ITPR1, BCL2More
Argatrobanhsa04810Regulation of actin cytoskeleton1.38E-034P24844, Q15746, P08514, P25116MYL9, MYLK, ITGA2B, F2RMore
Argatrobanhsa04913Ovarian steroidogenesis2.72E-022P42330, P22694AKR1C3, PRKACBMore
Argatrobanhsa04921Oxytocin signaling pathway6.37E-033Q15746, P24844, Q8WYR1MYLK, MYL9, PIK3R5More
Argatrobanhsa04924Renin secretion3.09E-033P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Argatrobanhsa04927Cortisol synthesis and secretion2.72E-022Q14643, P22694ITPR1, PRKACBMore
Argatrobanhsa04928Parathyroid hormone synthesis, secretion and action1.02E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Argatrobanhsa04934Cushing syndrome4.74E-023Q14643, P22694, P04628ITPR1, PRKACB, WNT1More
Argatrobanhsa04970Salivary secretion2.11E-023P07550, P22694, Q14643ADRB2, PRKACB, ITPR1More
Argatrobanhsa05130Pathogenic Escherichia coli infection2.51E-023Q14247, O00501, P25116CTTN, CLDN5, F2RMore
Argatrobanhsa05133Pertussis2.24E-022P0DP23, P0C0L4CALM1, C4AMore
Argatrobanhsa05143African trypanosomiasis4.81E-022P69905, P68871HBA2, HBBMore

Community members of Argatroban (SDC: 2.47)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00734F2ProthrombinReported10.09630.7070.49771.9598
P08514ITGA2BIntegrin alphaNoneIIbPredicted10.07820.32480.7791.4677
O14786NRP1NeuropilinNone1Predicted10.38340.20260.51531.1123
P21453S1PR1Sphingosine 1Nonephosphate receptor 1Predicted10.14340.38470.2211.0621
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
F2P00734IC503.9
F2P00734IC505.4
F2P00734IC509.5
F2P00734Ki4
F2P00734Ki10
F2P00734Ki19