PharmaCoNets of Arbutin (SPCN: 11.98 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Arbutinhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Arbutinhsa00250Alanine, aspartate and glutamate metabolism4.51E-021P51649ALDH5A1More
Arbutinhsa00531Glycosaminoglycan degradation3.03E-021P15586GNSMore
Arbutinhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Arbutinhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Arbutinhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Arbutinhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Arbutinhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Arbutinhsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Arbutinhsa01524Platinum drug resistance2.55E-022P04637, P48023TP53, FASLGMore
Arbutinhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Arbutinhsa04068FoxO signaling pathway6.45E-032P48023, Q96BR1FASLG, SGK3More
Arbutinhsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Arbutinhsa04151PI3K-Akt signaling pathway4.21E-033P48023, P04637, Q96BR1FASLG, TP53, SGK3More
Arbutinhsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Arbutinhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Arbutinhsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Arbutinhsa04613Neutrophil extracellular trap formation1.73E-024Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Arbutinhsa04640Hematopoietic cell lineage3.69E-024P21926, P07766, P01730, P09564CD9, CD3E, CD4, CD7More
Arbutinhsa04650Natural killer cell mediated cytotoxicity4.51E-022P48023, Q14953FASLG, KIR2DS5More
Arbutinhsa04722Neurotrophin signaling pathway2.27E-022P48023, P04637FASLG, TP53More
Arbutinhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Arbutinhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Arbutinhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Arbutinhsa05133Pertussis4.20E-021P0C0L4C4AMore
Arbutinhsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Arbutinhsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Arbutinhsa05160Hepatitis C3.81E-022P04637, P48023TP53, FASLGMore
Arbutinhsa05164Influenza A3.48E-022Q9GZY0, P48023NXF2; NXF2B, FASLGMore
Arbutinhsa05168Herpes simplex virus 1 infection4.54E-034P04637, Q9GZY0, P48023, P98182TP53, NXF2; NXF2B, FASLG, ZNF200More
Arbutinhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Arbutinhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Arbutinhsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Arbutinhsa05219Bladder cancer4.51E-021P04637TP53More
Arbutinhsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Arbutinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.09E-024P07766, P06239, Q9HC35, P01730CD3E, LCK, EML4, CD4More
Arbutinhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Arbutinhsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Arbutinhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Arbutin (SDC: 2.81)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P51649ALDH5A1SuccinateNonesemialdehyde dehydrogenase, mitochondrialPredicted00.1730.07780.1520.394
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)