PharmaCoNets of Apraclonidine (SPCN: 47.70 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Apraclonidinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Apraclonidinehsa00230Purine metabolism3.95E-023Q7LG56, P51828, Q9Y227RRM2B, ADCY7, ENTPD4More
Apraclonidinehsa00240Pyrimidine metabolism2.84E-022Q7LG56, Q9Y227RRM2B, ENTPD4More
Apraclonidinehsa00310Lysine degradation2.59E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Apraclonidinehsa00512Mucin type O-glycan biosynthesis4.86E-022O95395, Q9NY28GCNT3, GALNT8More
Apraclonidinehsa00630Glyoxylate and dicarboxylate metabolism9.62E-043P40925, P40926, P15104MDH1, MDH2, GLULMore
Apraclonidinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Apraclonidinehsa00830Retinol metabolism4.25E-021P00325ADH1BMore
Apraclonidinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Apraclonidinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Apraclonidinehsa03015mRNA surveillance pathway1.83E-023Q13362, Q14738, Q9UBU9PPP2R5C, PPP2R5D, NXF1More
Apraclonidinehsa03040Spliceosome4.48E-0410Q14562, O43143, O60508, P17844, P51991, P61978, Q07955, Q01130, Q13243, P11142DHX8, DHX15, CDC40, DDX5, HNRPA3, HNRPK, SFRS1, SFRS2, SFRS5, HSPA8More
Apraclonidinehsa03060Protein export1.49E-022P37108, Q15005SRP14, SPCS2More
Apraclonidinehsa04014Ras signaling pathway8.66E-037Q9NRA1, Q13009, P0DP23, P62873, P63218, P50151, P19174PDGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1More
Apraclonidinehsa04062Chemokine signaling pathway1.59E-039P07948, P19174, P62873, P63218, P50151, Q13009, P14598, P42224, P25963LYN, PLCG1, GNB1, GNG5, GNG10, TIAM1, NCF1, STAT1, NFKBIAMore
Apraclonidinehsa04070Phosphatidylinositol signaling system2.93E-024P19174, P0DP23, P23743, P27987PLCG1, CALM1, DGKA, ITPKBMore
Apraclonidinehsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Apraclonidinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Apraclonidinehsa04114Oocyte meiosis3.65E-023P0DP23, Q13362, Q14738CALM1, PPP2R5C, PPP2R5DMore
Apraclonidinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Apraclonidinehsa04141Protein processing in endoplasmic reticulum1.22E-0411P18848, P30101, Q15437, P60604, Q99941, P11142, P07900, P08238, Q9NR31, Q9H173, Q9UNL2ATF4, PDIA3, SEC23B, UBE2G2, CREBL1, HSPA8, HSP90AA1, HSP90AB1, SAR1A, SIL1, SSR3More
Apraclonidinehsa04145Phagosome6.51E-036P11215, P14598, Q71U36, Q13509, P68371, Q13488ITGAM, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1More
Apraclonidinehsa04151PI3K-Akt signaling pathway3.91E-037P62753, P27348, P07900, P22105, Q99941, P18848, O00141RPS6, YWHAQ, HSP90AA1, TNXB, CREBL1, ATF4, SGKMore
Apraclonidinehsa04152AMPK signaling pathway1.83E-023Q96RR4, Q13362, Q14738CAMKK2, PPP2R5C, PPP2R5DMore
Apraclonidinehsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Apraclonidinehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Apraclonidinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Apraclonidinehsa04261Adrenergic signaling in cardiomyocytes1.73E-049P07550, P51828, P22694, Q99941, P18848, Q13362, Q14738, P0DP23, Q13557ADRB2, ADCY7, PRKACB, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CAMK2DMore
Apraclonidinehsa04371Apelin signaling pathway7.95E-047P62873, P63218, P50151, Q13370, Q14344, P84022, P0DP23GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD3, CALM1More
Apraclonidinehsa04540Gap junction1.08E-024Q13509, P68371, Q71U36, Q9NRA1TUBB3, TUBB2C, TUBA1A, PDGFCMore
Apraclonidinehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Apraclonidinehsa04613Neutrophil extracellular trap formation1.23E-035P11215, Q13547, P58876, Q16778, O60814ITGAM, HDAC1, H2BC5, HIST2H2BE, H2BC12More
Apraclonidinehsa04623Cytosolic DNA-sensing pathway2.59E-022P01568, P25963IFNA21, NFKBIAMore
Apraclonidinehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Apraclonidinehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Apraclonidinehsa04659Th17 cell differentiation1.11E-026P25963, P19174, P42224, P14784, P84022, P08238NFKBIA, PLCG1, STAT1, IL2RB, SMAD3, HSP90AB1More
Apraclonidinehsa04664Fc epsilon RI signaling pathway6.97E-034P04141, P07948, P19174, P09917CSF2, LYN, PLCG1, ALOX5More
Apraclonidinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Apraclonidinehsa04713Circadian entrainment2.18E-024P0DP23, P62873, P63218, P50151CALM1, GNB1, GNG5, GNG10More
Apraclonidinehsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Apraclonidinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Apraclonidinehsa04724Glutamatergic synapse1.57E-024P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Apraclonidinehsa04725Cholinergic synapse2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Apraclonidinehsa04726Serotonergic synapse3.80E-024P62873, P63218, P50151, P09917GNB1, GNG5, GNG10, ALOX5More
Apraclonidinehsa04727GABAergic synapse4.18E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Apraclonidinehsa04728Dopaminergic synapse3.20E-036Q99941, P18848, Q13557, Q13362, Q14738, P0DP23CREBL1, ATF4, CAMK2D, PPP2R5C, PPP2R5D, CALM1More
Apraclonidinehsa04730Long-term depression4.86E-022Q14344, P07948GNA13, LYNMore
Apraclonidinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Apraclonidinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Apraclonidinehsa04744Phototransduction9.21E-032P62873, P0DP23GNB1, CALM1More
Apraclonidinehsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Apraclonidinehsa04912GnRH signaling pathway2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Apraclonidinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Apraclonidinehsa04915Estrogen signaling pathway2.75E-035Q99941, P18848, P51828, P07900, P11142CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8More
Apraclonidinehsa04918Thyroid hormone synthesis2.41E-045P51828, Q99941, P18848, P02768, P05543ADCY7, CREBL1, ATF4, ALB, SERPINA7More
Apraclonidinehsa04921Oxytocin signaling pathway3.13E-023P0DP23, Q96RR4, Q13469CALM1, CAMKK2, NFATC2More
Apraclonidinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Apraclonidinehsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Apraclonidinehsa04926Relaxin signaling pathway2.06E-036Q99941, P18848, P22694, P14780, P51828, P30679CREBL1, ATF4, PRKACB, MMP9, ADCY7, GNA15More
Apraclonidinehsa04927Cortisol synthesis and secretion2.72E-044Q99941, P18848, P51828, P22694CREBL1, ATF4, ADCY7, PRKACBMore
Apraclonidinehsa04928Parathyroid hormone synthesis, secretion and action2.17E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Apraclonidinehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Apraclonidinehsa04934Cushing syndrome1.12E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Apraclonidinehsa04935Growth hormone synthesis, secretion and action2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Apraclonidinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Apraclonidinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Apraclonidinehsa04979Cholesterol metabolism1.61E-022P38571, P61916LIPA, NPC2More
Apraclonidinehsa05012Parkinson disease1.77E-026P60604, P19174, P0DP23, Q71U36, Q13509, P68371UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2CMore
Apraclonidinehsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Apraclonidinehsa05031Amphetamine addiction8.84E-045Q13557, P22694, Q99941, P18848, Q13547CAMK2D, PRKACB, CREBL1, ATF4, HDAC1More
Apraclonidinehsa05032Morphine addiction2.18E-024P62873, P63218, P50151, Q13370GNB1, GNG5, GNG10, PDE3BMore
Apraclonidinehsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Apraclonidinehsa05120Epithelial cell signaling in Helicobacter pylori infection1.08E-024P25963, Q13488, P19174, P07948NFKBIA, TCIRG1, PLCG1, LYNMore
Apraclonidinehsa05130Pathogenic Escherichia coli infection3.19E-026Q71U36, P16333, Q13509, P68371, Q14344, P25963TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIAMore
Apraclonidinehsa05132Salmonella infection2.75E-027P25963, P08238, O75369, Q71U36, Q13509, P68371, P49754NFKBIA, HSP90AB1, FLNB, TUBA1A, TUBB3, TUBB2C, VPS41More
Apraclonidinehsa05134Legionellosis4.75E-023P25963, P11215, P11142NFKBIA, ITGAM, HSPA8More
Apraclonidinehsa05140Leishmaniasis4.82E-024P14598, P11215, P42224, P25963NCF1, ITGAM, STAT1, NFKBIAMore
Apraclonidinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Apraclonidinehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Apraclonidinehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Apraclonidinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Apraclonidinehsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Apraclonidinehsa05163Human cytomegalovirus infection2.56E-038P25963, P62873, P63218, P50151, P0DP23, Q14344, P30101, P01568NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, PDIA3, IFNA21More
Apraclonidinehsa05167Kaposi sarcoma-associated herpesvirus infection1.17E-0512P01568, P42224, P25963, P23458, P62873, P63218, P50151, P19174, Q13469, P07948, P04141, P0DP23IFNA21, STAT1, NFKBIA, JAK1, GNB1, GNG5, GNG10, PLCG1, NFATC2, LYN, CSF2, CALM1More
Apraclonidinehsa05168Herpes simplex virus 1 infection3.79E-029P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, Q13398, O75820NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, ZNF211, ZNF189More
Apraclonidinehsa05170Human immunodeficiency virus 1 infection1.19E-028P62873, P63218, P50151, P0DP23, P30101, P01568, P25963, P19174GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, NFKBIA, PLCG1More
Apraclonidinehsa05200Pathways in cancer1.99E-0315P08238, P42224, P25963, P19174, P43246, P84022, P20585, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, MSH3, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RBMore
Apraclonidinehsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Apraclonidinehsa05203Viral carcinogenesis5.38E-048Q99941, P18848, P27348, Q13547, P61978, P58876, Q16778, O60814CREBL1, ATF4, YWHAQ, HDAC1, HNRPK, H2BC5, HIST2H2BE, H2BC12More
Apraclonidinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Apraclonidinehsa05212Pancreatic cancer5.39E-035Q15311, P23458, P42224, P84022, O75293RALBP1, JAK1, STAT1, SMAD3, GADD45BMore
Apraclonidinehsa05214Glioma4.75E-023P0DP23, P19174, O75293CALM1, PLCG1, GADD45BMore
Apraclonidinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Apraclonidinehsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Apraclonidinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Apraclonidinehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More

Community members of Apraclonidine (SDC: 3.47)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
Q9Y2I1NISCHNischarinPredicted10.60820.225100.7543
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P17707AMD1SNoneadenosylmethionine decarboxylase proenzymePredicted00.80270.05050.16450.6667
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)