PharmaCoNets of Apomorphine (SPCN: 85.36 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Apomorphinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Apomorphinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Apomorphinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Apomorphinehsa00500Starch and sucrose metabolism1.47E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Apomorphinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Apomorphinehsa00730Thiamine metabolism4.07E-022P05186, P24666ALPL, ACP1More
Apomorphinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Apomorphinehsa00983Drug metabolism - other enzymes3.50E-023P04183, P32320, P05164TK1, CDA, MPOMore
Apomorphinehsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Apomorphinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Apomorphinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Apomorphinehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Apomorphinehsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Apomorphinehsa03010Ribosome1.03E-022P46777, P50914RPL5, RPL14More
Apomorphinehsa03013RNA transport3.98E-029P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Apomorphinehsa03020RNA polymerase1.81E-021P24928POLR2AMore
Apomorphinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Apomorphinehsa04012ErbB signaling pathway3.31E-021Q13153PAK1More
Apomorphinehsa04024cAMP signaling pathway4.80E-021Q13153PAK1More
Apomorphinehsa04064NF-kappa B signaling pathway7.08E-0514P10415, Q13489, O00463, Q13546, P14778, Q04759, Q9UDY8, Q13077, Q16548, Q8WV28, Q13315, P24522, P09341, Q9UNE0BCL2, BIRC3, TRAF5, RIPK1, IL1R1, PRKCQ, MALT1, TRAF1, BCL2A1, BLNK, ATM, GADD45A, CXCL1, EDARMore
Apomorphinehsa04071Sphingolipid signaling pathway7.35E-057P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Apomorphinehsa04080Neuroactive ligand-receptor interaction2.16E-039P08311, P28472, Q15722, P21453, Q9H228, O00398, P21730, Q16581, P07550CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1, ADRB2More
Apomorphinehsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Apomorphinehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Apomorphinehsa04115p53 signaling pathway3.98E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Apomorphinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Apomorphinehsa04142Lysosome3.31E-023P43234, Q9UBR2, P34059CTSO, CTSZ, GALNSMore
Apomorphinehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Apomorphinehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Apomorphinehsa04210Apoptosis3.77E-028Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1More
Apomorphinehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Apomorphinehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Apomorphinehsa04217Necroptosis1.85E-037P01375, P01568, P48023, Q13489, Q13546, Q14765, Q99878TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT4, H2AC14More
Apomorphinehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Apomorphinehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Apomorphinehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Apomorphinehsa04392Hippo signaling pathway - multiple species1.51E-021Q13153PAK1More
Apomorphinehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Apomorphinehsa04612Antigen processing and presentation2.09E-048P13765, P48382, Q14953, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Apomorphinehsa04613Neutrophil extracellular trap formation3.12E-0521P11215, O60603, P05164, P08246, Q9UM07, Q13547, P04908, Q6FI13, Q93077, P58876, Q16778, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Apomorphinehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Apomorphinehsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Apomorphinehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Apomorphinehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Apomorphinehsa04625C-type lectin receptor signaling pathway3.31E-021Q13153PAK1More
Apomorphinehsa04630JAK-STAT signaling pathway1.44E-024P01106, Q09472, P48551, P16871MYC, EP300, IFNAR2, IL7RMore
Apomorphinehsa04640Hematopoietic cell lineage1.75E-038P21926, P20023, P11836, P07766, P09693, P01730, P09564, P16871CD9, CR2, MS4A1, CD3E, CD3G, CD4, CD7, IL7RMore
Apomorphinehsa04650Natural killer cell mediated cytotoxicity4.51E-0611P16298, P50591, P01375, P20963, Q02750, Q13153, Q13241, P26718, P26717, Q14953, P26715PPP3CB, TNFSF10, TNF, CD247, MAP2K1, PAK1, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Apomorphinehsa04657IL-17 signaling pathway5.71E-049O00463, Q16539, P49841, P09341, P19875, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, ANAPC5, LCN2, TNFMore
Apomorphinehsa04660T cell receptor signaling pathway3.61E-021Q13153PAK1More
Apomorphinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Apomorphinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Apomorphinehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Apomorphinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Apomorphinehsa04725Cholinergic synapse4.83E-024P22694, Q14643, P18848, P10415PRKACB, ITPR1, ATF4, BCL2More
Apomorphinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Apomorphinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Apomorphinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Apomorphinehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Apomorphinehsa04915Estrogen signaling pathway2.96E-025P14780, P22694, P18848, Q14643, P10415MMP9, PRKACB, ATF4, ITPR1, BCL2More
Apomorphinehsa04918Thyroid hormone synthesis3.50E-023P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Apomorphinehsa04919Thyroid hormone signaling pathway4.44E-023P60709, Q09472, P01106ACTB, EP300, MYCMore
Apomorphinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Apomorphinehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Apomorphinehsa04927Cortisol synthesis and secretion4.44E-043Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Apomorphinehsa04928Parathyroid hormone synthesis, secretion and action2.13E-025Q14643, P22694, P23771, P18848, P10415ITPR1, PRKACB, GATA3, ATF4, BCL2More
Apomorphinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Apomorphinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Apomorphinehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Apomorphinehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Apomorphinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Apomorphinehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Apomorphinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Apomorphinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Apomorphinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Apomorphinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Apomorphinehsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Apomorphinehsa05120Epithelial cell signaling in Helicobacter pylori infection3.10E-035Q16539, Q13153, P09341, P25024, P25025MAPK14, PAK1, CXCL1, CXCR1, CXCR2More
Apomorphinehsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Apomorphinehsa05133Pertussis4.20E-021P0C0L4C4AMore
Apomorphinehsa05140Leishmaniasis2.69E-025O75015, P13765, O60603, P49006, Q16539FCGR3B, HLA-DOB, TLR2, MARCKSL1, MAPK14More
Apomorphinehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Apomorphinehsa05144Malaria1.44E-035P69905, P68871, P01375, P35443, P26718HBA2, HBB, TNF, THBS4, KLRK1More
Apomorphinehsa05146Amoebiasis3.33E-039P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACBMore
Apomorphinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Apomorphinehsa05163Human cytomegalovirus infection3.64E-027Q14643, P49841, P14778, P25025, Q16539, P04637, O00463ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Apomorphinehsa05164Influenza A8.62E-034Q09472, P48551, P29728, P60709EP300, IFNAR2, OAS2, ACTBMore
Apomorphinehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Apomorphinehsa05169Epstein-Barr virus infection1.42E-025P20023, P01106, P48551, P29728, P09693CR2, MYC, IFNAR2, OAS2, CD3GMore
Apomorphinehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Apomorphinehsa05171Coronavirus disease - COVID-191.93E-024P48551, P29728, P46777, P50914IFNAR2, OAS2, RPL5, RPL14More
Apomorphinehsa05202Transcriptional misregulation in cancer1.08E-0419Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, P11215, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, ITGAM, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45AMore
Apomorphinehsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Apomorphinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Apomorphinehsa05211Renal cell carcinoma3.42E-033Q09472, Q99814, Q13153EP300, EPAS1, PAK1More
Apomorphinehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Apomorphinehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Apomorphinehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Apomorphinehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Apomorphinehsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Apomorphinehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Apomorphinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.94E-038O95267, P07766, P09693, P06239, O60603, Q16539, Q9HC35, P01730RASGRP1, CD3E, CD3G, LCK, TLR2, MAPK14, EML4, CD4More
Apomorphinehsa05321Inflammatory bowel disease1.19E-036P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Apomorphinehsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Apomorphinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Apomorphinehsa05332Graft-versus-host disease1.91E-056P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Apomorphinehsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Apomorphinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Apomorphinehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Apomorphinehsa05418Fluid shear stress and atherosclerosis2.62E-026Q16539, P10599, P14780, P04637, P14778, P27930MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2More

Community members of Apomorphine (SDC: 6.19)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
Q13153PAK1Serine/threonineNoneprotein kinase PAK 1Predicted10.46470.34710.78191.7084
P07101THTyrosine 3NonemonooxygenasePredicted00.04320.08880.49370.6929
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
DRD2P14416IC504.2
DRD2P14416Ki0.62
DRD2P14416Ki3.6
DRD2P14416Ki26
DRD2P14416Kd0.66
DRD2P14416Kd24
DRD2P14416Kd127