PharmaCoNets

PharmaCoNets of Antrafenine (S_PCN: 76.89 )

Antrafenine regulated-network (S_DN: 14.51)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Antrafenine

hsa00030

Pentose phosphate pathway

4.23E-02

P51854, P37837

TKTL1, TALDO1

Antrafenine

hsa00190

Oxidative phosphorylation

2.29E-02

Q16718, O14521

NDUFA5, SDHD

Antrafenine

hsa00220

Arginine biosynthesis

1.26E-03

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Antrafenine

hsa00250

Alanine, aspartate and glutamate metabolism

2.42E-02

P15104

GLUL

Antrafenine

hsa00310

Lysine degradation

3.15E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Antrafenine

hsa00500

Starch and sucrose metabolism

2.21E-03

O43451, P46976, P35573, P06737

MGAM, GYG1, AGL, PYGL

Antrafenine

hsa00510

N-Glycan biosynthesis

3.15E-02

P15907, Q9NR34

ST6GAL1, MAN1C1

Antrafenine

hsa00630

Glyoxylate and dicarboxylate metabolism

1.13E-02

P40925, P15104

MDH1, GLUL

Antrafenine

hsa00730

Thiamine metabolism

4.07E-02

P05186, P24666

ALPL, ACP1

Antrafenine

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Antrafenine

hsa00830

Retinol metabolism

3.93E-02

P00352, Q9BPW9, O75911

ALDH1A1, DHRS9, DHRS3

Antrafenine

hsa00910

Nitrogen metabolism

2.42E-02

P15104

GLUL

Antrafenine

hsa00983

Drug metabolism - other enzymes

2.83E-02

P20839, P32320, P05164

IMPDH1, CDA, MPO

Antrafenine

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Antrafenine

hsa01230

Biosynthesis of amino acids

5.53E-03

P15104, P37837

GLUL, TALDO1

Antrafenine

hsa02010

ABC transporters

2.29E-02

P45844, P08183

ABCG1, ABCB1

Antrafenine

hsa03013

RNA transport

4.49E-02

P62826, Q9UBU9, P63279, P68104, Q14232

RAN, NXF1, UBE2I, EEF1A1, EIF2B1

Antrafenine

hsa03020

RNA polymerase

6.21E-04

P30876, P24928, P62487, Q9Y535

POLR2B, POLR2A, POLR2G, POLR3H

Antrafenine

hsa03022

Basal transcription factors

2.72E-03

O00268, Q12962, Q15544

TAF4, TAF10, TAF11

Antrafenine

hsa03040

Spliceosome

2.10E-04

O60508, P08579, P26368, Q13595, Q01130, P84103, Q13243, P11142, Q9Y2W2, O75643

CDC40, SNRPB2, U2AF2, TRA2A, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, ASCC3L1

Antrafenine

hsa03060

Protein export

1.81E-02

Q15070

OXA1L

Antrafenine

hsa03320

PPAR signaling pathway

3.60E-02

Q13418

ILK

Antrafenine

hsa04020

Calcium signaling pathway

4.83E-02

Q08828, P0DP23, P05141, P51828

ADCY1, CALM1, SLC25A5, ADCY7

Antrafenine

hsa04022

cGMP-PKG signaling pathway

4.38E-03

P18848, P31751, Q08828, P51828, P05141, P0DP23

ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1

Antrafenine

hsa04024

cAMP signaling pathway

3.94E-02

Q08828, P51828, P31751, P0DP23

ADCY1, ADCY7, AKT2, CALM1

Antrafenine

hsa04060

Cytokine-cytokine receptor interaction

5.34E-03

P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730

IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4

Antrafenine

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.28E-03

Q8NHW4, P09341, P25024, P47992, Q9UBD3, Q13651, P14784

CCL4L2, CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RB

Antrafenine

hsa04062

Chemokine signaling pathway

6.73E-03

P25024, P09341, P47992, Q9UBD3, P07948, P63218, P50151, P43250, Q08881

CXCR1, CXCL1, XCL1, XCL2, LYN, GNG5, GNG10, GRK6, ITK

Antrafenine

hsa04064

NF-kappa B signaling pathway

1.06E-07

P10415, O00463, P14778, P01584, P01375, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q06643, Q9NQC7

BCL2, TRAF5, IL1R1, IL1B, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P10415	BCL2	Apoptosis regulator Bcl-2	0.744
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O00463	TRAF5	TNF receptor-associated factor 5	0.945
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.721
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13077	TRAF1	TNF receptor-associated factor 1	0.83
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q16548	BCL2A1	Bcl-2-related protein A1	-0.877
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13315	ATM	Serine-protein kinase ATM	0.752
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.75
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09341	CXCL1	Growth-regulated alpha protein	-0.802
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753

Antrafenine

hsa04070

Phosphatidylinositol signaling system

9.86E-03

P0DP23, O14986, Q16760, P48426

CALM1, PIP5K1B, DGKD, PIP4K2A

Antrafenine

hsa04071

Sphingolipid signaling pathway

2.16E-02

P21453, Q9H228, P01375, Q13362, Q9BX95

S1PR1, EDG8, TNF, PPP2R5C, SGPP1

Antrafenine

hsa04072

Phospholipase D signaling pathway

2.40E-03

P31751, O14986, Q15438, Q08828, P51828, Q16760

AKT2, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKD

Antrafenine

hsa04080

Neuroactive ligand-receptor interaction

2.16E-02

P08311, Q15722, P21453, Q9H228, P21462, P21730, P07550

CTSG, LTB4R, S1PR1, EDG8, FPR1, C5AR1, ADRB2

Antrafenine

hsa04114

Oocyte meiosis

1.35E-02

P0DP23, Q08828, P51828, Q13362, Q14738

CALM1, ADCY1, ADCY7, PPP2R5C, PPP2R5D

Antrafenine

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Antrafenine

hsa04140

Autophagy - animal

5.56E-03

P31751, Q7L523, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9

AKT2, RRAGA, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8

Antrafenine

hsa04142

Lysosome

2.64E-02

Q99437, P25774

ATP6V0B, CTSS

Antrafenine

hsa04144

Endocytosis

2.81E-02

Q13191, P11142, P25024, P43250, P14784, Q9Y5X3

CBLB, HSPA8, CXCR1, GRK6, IL2RB, SNX5

Antrafenine

hsa04145

Phagosome

2.18E-03

O75015, Q15080, Q99437, P05164, P78380, O60603, P35443, P13765, P25774

FCGR3B, NCF4, ATP6V0B, MPO, OLR1, TLR2, THBS4, HLA-DOB, CTSS

Antrafenine

hsa04211

Longevity regulating pathway

1.88E-02

P31751, Q08828, P51828, P18848

AKT2, ADCY1, ADCY7, ATF4

Antrafenine

hsa04213

Longevity regulating pathway - multiple species

4.54E-02

P31751, Q08828, P51828

AKT2, ADCY1, ADCY7

Antrafenine

hsa04217

Necroptosis

2.34E-02

P01375, P48023, Q14765, Q99878

TNF, FASLG, STAT4, H2AC14

Antrafenine

hsa04261

Adrenergic signaling in cardiomyocytes

4.98E-04

Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23

ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1

Antrafenine

hsa04371

Apelin signaling pathway

3.94E-02

P31751, Q08828, P51828, P0DP23

AKT2, ADCY1, ADCY7, CALM1

Antrafenine

hsa04380

Osteoclast differentiation

1.88E-02

Q9NQC7, P23458, P31751, P01584

CYLD, JAK1, AKT2, IL1B

Antrafenine

hsa04612

Antigen processing and presentation

4.21E-05

P13765, P48382, P01730, P26715, P26717, Q13241, P01732, P01375

HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P48382	RFX5	DNA-binding protein RFX5	0.726
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P48382	RFX5	DNA-binding protein RFX5	0.826
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.972
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.943
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P26717	KLRC2	NKG2-C type II integral membrane protein	0.972
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26717	KLRC2	NKG2-C type II integral membrane protein	0.943
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q13241	KLRD1	Natural killer cells antigen CD94	0.883
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13241	KLRD1	Natural killer cells antigen CD94	0.852
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.803
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P01375	TNF	Tumor necrosis factor	-0.813
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79

Antrafenine

hsa04613

Neutrophil extracellular trap formation

2.25E-03

P05164, P08246, Q9UM07, P04908, Q93077, P68431, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

MPO, ELA2, PADI4, H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Antrafenine

hsa04620

Toll-like receptor signaling pathway

2.54E-03

P01584, P31751, Q8NHW4

IL1B, AKT2, CCL4L2

Antrafenine

hsa04623

Cytosolic DNA-sensing pathway

2.21E-04

P01584, Q9Y535, Q8NHW4

IL1B, POLR3H, CCL4L2

Antrafenine

hsa04625

C-type lectin receptor signaling pathway

9.86E-03

P01584, Q9NQC7, P31751, P0DP23

IL1B, CYLD, AKT2, CALM1

Antrafenine

hsa04630

JAK-STAT signaling pathway

4.54E-02

P31751, P23458, Q13651

AKT2, JAK1, IL10RA

Antrafenine

hsa04640

Hematopoietic cell lineage

7.06E-05

P13612, P14778, P27930, P15144, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375

ITGA4, IL1R1, IL1R2, ANPEP, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF

Antrafenine

hsa04650

Natural killer cell mediated cytotoxicity

2.27E-06

P01375, P06239, O60880, P20963, Q13241, P26718, O14931, O75015, P26717, P26715

TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P01375	TNF	Tumor necrosis factor	-0.813
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	O60880	SH2D1A	SH2 domain-containing protein 1A	0.912
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60880	SH2D1A	SH2 domain-containing protein 1A	0.862
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.776
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q13241	KLRD1	Natural killer cells antigen CD94	0.883
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13241	KLRD1	Natural killer cells antigen CD94	0.852
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P26718	KLRK1	NKG2-D type II integral membrane protein	0.794
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26718	KLRK1	NKG2-D type II integral membrane protein	0.922
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.704
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.778
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P26717	KLRC2	NKG2-C type II integral membrane protein	0.972
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26717	KLRC2	NKG2-C type II integral membrane protein	0.943
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.972
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.943

Antrafenine

hsa04657

IL-17 signaling pathway

5.82E-03

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Antrafenine

hsa04658

Th1 and Th2 cell differentiation

2.19E-10

Q04759, P07766, P20963, P09693, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q04759	PRKCQ	Protein kinase C theta type	0.755
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.776
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q14765	STAT4	Signal transducer and activator of transcription 4	0.928
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q14765	STAT4	Signal transducer and activator of transcription 4	0.904
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.784
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q9UL17	TBX21	T-box transcription factor TBX21	0.852
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UL17	TBX21	T-box transcription factor TBX21	0.884
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85

Antrafenine

hsa04659

Th17 cell differentiation

2.63E-08

Q04759, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, Q13485, P08238, P07766, P09693, P20963

PRKCQ, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9HBE5	IL21R	Interleukin-21 receptor	0.713
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UL17	TBX21	T-box transcription factor TBX21	0.884
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.784
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839

Antrafenine

hsa04660

T cell receptor signaling pathway

3.89E-07

P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239

TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P01375	TNF	Tumor necrosis factor	-0.813
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.721
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q04759	PRKCQ	Protein kinase C theta type	0.755
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.79
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.754
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.873
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	1
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.776
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.803
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.734
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.811
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774

Antrafenine

hsa04662

B cell receptor signaling pathway

4.07E-02

P42338, P60033, P07948, Q8N149

PIK3CB, CD81, LYN, LILRA2

Antrafenine

hsa04713

Circadian entrainment

4.54E-02

P0DP23, Q08828, P51828

CALM1, ADCY1, ADCY7

Antrafenine

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Antrafenine

hsa04720

Long-term potentiation

4.54E-02

P0DP23, P18848, Q08828

CALM1, ATF4, ADCY1

Antrafenine

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Antrafenine

hsa04724

Glutamatergic synapse

2.22E-02

O15399, P63218, P50151, P15104

GRIN2D, GNG5, GNG10, GLUL

Antrafenine

hsa04725

Cholinergic synapse

1.39E-02

Q08828, P51828, P18848, P31751

ADCY1, ADCY7, ATF4, AKT2

Antrafenine

hsa04727

GABAergic synapse

4.42E-02

P63218, P50151, P15104

GNG5, GNG10, GLUL

Antrafenine

hsa04728

Dopaminergic synapse

7.83E-03

P31751, P18848, Q13362, Q14738, P0DP23

AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1

Antrafenine

hsa04750

Inflammatory mediator regulation of TRP channels

9.86E-03

P01584, Q08828, P51828, P0DP23

IL1B, ADCY1, ADCY7, CALM1

Antrafenine

hsa04911

Insulin secretion

2.40E-02

Q08828, P51828, P18848

ADCY1, ADCY7, ATF4

Antrafenine

hsa04912

GnRH signaling pathway

1.39E-02

Q08828, P51828, P18848, P0DP23

ADCY1, ADCY7, ATF4, CALM1

Antrafenine

hsa04915

Estrogen signaling pathway

2.13E-02

P18848, Q08828, P51828, P31751, P0DP23

ATF4, ADCY1, ADCY7, AKT2, CALM1

Antrafenine

hsa04916

Melanogenesis

2.40E-02

P0DP23, Q08828, P51828

CALM1, ADCY1, ADCY7

Antrafenine

hsa04923

Regulation of lipolysis in adipocytes

5.15E-03

Q08828, P51828, P31751

ADCY1, ADCY7, AKT2

Antrafenine

hsa04924

Renin secretion

1.55E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Antrafenine

hsa04925

Aldosterone synthesis and secretion

9.86E-03

P18848, Q08828, P51828, P0DP23

ATF4, ADCY1, ADCY7, CALM1

Antrafenine

hsa04926

Relaxin signaling pathway

2.46E-02

P31751, P18848, Q08828, P51828

AKT2, ATF4, ADCY1, ADCY7

Antrafenine

hsa04927

Cortisol synthesis and secretion

1.59E-02

P18848, Q08828, P51828

ATF4, ADCY1, ADCY7

Antrafenine

hsa04932

Non-alcoholic fatty liver disease

5.67E-05

P31751, P01375, P49841, P18848, P48023, O75460, P01584, Q16718, O95298, O14521

AKT2, TNF, GSK3B, ATF4, FASLG, ERN1, IL1B, NDUFA5, NDUFC2, SDHD

Antrafenine

hsa04934

Cushing syndrome

4.54E-02

P18848, Q08828, P51828

ATF4, ADCY1, ADCY7

Antrafenine

hsa04935

Growth hormone synthesis, secretion and action

1.88E-02

Q08828, P51828, P18848, P31751

ADCY1, ADCY7, ATF4, AKT2

Antrafenine

hsa04940

Type I diabetes mellitus

7.38E-04

P10747, P48023, P13765, P01375

CD28, FASLG, HLA-DOB, TNF

Antrafenine

hsa04970

Salivary secretion

6.79E-04

P07550, Q08828, P51828, P22694, Q14643, P0DP23, P49913

ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, CALM1, CAMP

Antrafenine

hsa04971

Gastric acid secretion

2.54E-03

Q08828, P51828, P15311, P0DP23

ADCY1, ADCY7, VIL2, CALM1

Antrafenine

hsa04976

Bile secretion

9.77E-04

O43315, Q08828, P51828, P08183, Q14032

AQP9, ADCY1, ADCY7, ABCB1, BAAT

Antrafenine

hsa05010

Alzheimer disease

4.94E-03

O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070

NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4

Antrafenine

hsa05016

Huntington disease

2.24E-02

O95298, P24928, P30876, P62487, P05141, O75460, P28070

NDUFC2, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4

Antrafenine

hsa05017

Spinocerebellar ataxia

2.86E-03

Q92915, O75460, O15399, P42338, P31751, P28070, P05141, P21796

FGF14, ERN1, GRIN2D, PIK3CB, AKT2, PSMB4, SLC25A5, VDAC1

Antrafenine

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Antrafenine

hsa05022

Pathways of neurodegeneration - multiple diseases

4.63E-04

P49841, Q16718, O95298, O14521, Q8TEV9, O75460, P18848, Q13561, P05141, Q16539, Q00535, P01584, Q08752, P0DP23, P28070

GSK3B, NDUFA5, NDUFC2, SDHD, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, MAPK14, CDK5, IL1B, PPID, CALM1, PSMB4

Antrafenine

hsa05110

Vibrio cholerae infection

4.78E-02

Q99437

ATP6V0B

Antrafenine

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.45E-02

Q16539, P09341, P25024, P25025

MAPK14, CXCL1, CXCR1, CXCR2

Antrafenine

hsa05140

Leishmaniasis

2.66E-03

P13612, O75015, P13765, O60603, P01375, P49006, Q16539, Q15080

ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MARCKSL1, MAPK14, NCF4

Antrafenine

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Antrafenine

hsa05144

Malaria

1.14E-02

P60033, O60603, P01375, P35443, P26718

CD81, TLR2, TNF, THBS4, KLRK1

Antrafenine

hsa05146

Amoebiasis

1.37E-05

P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311

CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P09341	CXCL1	Growth-regulated alpha protein	-0.826
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09341	CXCL1	Growth-regulated alpha protein	-0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P27930	IL1R2	Interleukin-1 receptor type 2	-0.727
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P01375	TNF	Tumor necrosis factor	-0.813
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60603	TLR2	Toll-like receptor 2	-0.714
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P05089	ARG1	Arginase-1	-0.791
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P05089	ARG1	Arginase-1	-0.868
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.873
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P08311	CTSG	Cathepsin G	-0.847
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P08311	CTSG	Cathepsin G	-0.866

Antrafenine

hsa05150

Staphylococcus aureus infection

2.66E-03

P21730, P21462, O75015, P13765, P12838, P49913

C5AR1, FPR1, FCGR3B, HLA-DOB, DEFA4, CAMP

Antrafenine

hsa05152

Tuberculosis

4.16E-02

Q99437, P25774

ATP6V0B, CTSS

Antrafenine

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Antrafenine

hsa05163

Human cytomegalovirus infection

4.24E-05

P31751, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P04637, O00463

AKT2, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5

Antrafenine

hsa05164

Influenza A

4.49E-02

P31751, P01584, P23458, P05141, Q9UBU9

AKT2, IL1B, JAK1, SLC25A5, NXF1

Antrafenine

hsa05166

Human T-cell leukemia virus 1 infection

3.90E-02

P23458, P05141, P62826, Q08828, P51828, P18848, P31751

JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2

Antrafenine

hsa05169

Epstein-Barr virus infection

4.84E-03

P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963

HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247

Antrafenine

hsa05202

Transcriptional misregulation in cancer

3.33E-04

Q12778, Q13315, P41732, P14780, P27930, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P24522

FOXO1, ATM, TSPAN7, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q12778	FOXO1	Forkhead box protein O1	0.716
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q13315	ATM	Serine-protein kinase ATM	0.858
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13315	ATM	Serine-protein kinase ATM	0.752
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P41732	TSPAN7	Tetraspanin-7	-0.733
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P14780	MMP9	Matrix metalloproteinase-9	-0.826
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P14780	MMP9	Matrix metalloproteinase-9	-0.855
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P27930	IL1R2	Interleukin-1 receptor type 2	-0.727
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.833
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q16548	BCL2A1	Bcl-2-related protein A1	-0.769
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q16548	BCL2A1	Bcl-2-related protein A1	-0.877
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13077	TRAF1	TNF receptor-associated factor 1	0.83
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P35226	BMI1	Polycomb complex protein BMI-1	0.759
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P35226	BMI1	Polycomb complex protein BMI-1	0.76
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P35226	BMI1	Polycomb complex protein BMI-1	0.759
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P35226	BMI1	Polycomb complex protein BMI-1	0.76
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P05164	MPO	Myeloperoxidase	-0.817
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P05164	MPO	Myeloperoxidase	-0.811
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P12838	DEFA4	Neutrophil defensin 4	-0.796
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P12838	DEFA4	Neutrophil defensin 4	-0.86
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P08246	ELA2	Neutrophil elastase	-0.772
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P08246	ELA2	Neutrophil elastase	-0.782
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.807
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.9
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.75

Antrafenine

hsa05212

Pancreatic cancer

2.40E-02

P31751, Q15311, P23458

AKT2, RALBP1, JAK1

Antrafenine

hsa05213

Endometrial cancer

3.60E-02

Q13418

ILK

Antrafenine

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Antrafenine

hsa05224

Breast cancer

4.75E-02

P49841, Q92837, P04637, P24522

GSK3B, FRAT1, TP53, GADD45A

Antrafenine

hsa05231

Choline metabolism in cancer

3.38E-02

P31751, Q16760, O14986

AKT2, DGKD, PIP5K1B

Antrafenine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.32E-03

O95267, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730

RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4

Antrafenine

hsa05310

Asthma

2.42E-04

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Antrafenine

hsa05321

Inflammatory bowel disease

8.83E-07

O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Antrafenine

hsa05322

Systemic lupus erythematosus

4.51E-02

O75015, P08246, P08311, P01375, P10747, P13765

FCGR3B, ELA2, CTSG, TNF, CD28, HLA-DOB

Antrafenine

hsa05323

Rheumatoid arthritis

2.62E-02

P01375, P13765, P10747, P09341

TNF, HLA-DOB, CD28, CXCL1

Antrafenine

hsa05330

Allograft rejection

2.02E-03

P13765, P48023, P10747, P01375

HLA-DOB, FASLG, CD28, TNF

Antrafenine

hsa05332

Graft-versus-host disease

5.83E-07

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Antrafenine

hsa05340

Primary immunodeficiency

2.19E-02

P01730, P01732, P07766, P06239

CD4, CD8A, CD3E, LCK

Antrafenine

hsa05415

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Antrafenine

hsa05418

Fluid shear stress and atherosclerosis

2.62E-02

Q16539, P10599, P14780, P04637, P14778, P27930

MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2

Community members of Antrafenine (S_DC: 5.30)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

LCK

TyrosineNoneprotein kinase Lck

Predicted

0.0576

0.7287

2.7575

Q02763

TEK

AngiopoietinNone1 receptor

Predicted

0.3206

0.6236

0.4304

1.8379

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

P07948

LYN

TyrosineNoneprotein kinase Lyn

Predicted

0.091

0.5319

0.606

1.7154

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P25774

CTSS

Cathepsin S

Predicted

0.3185

0.4932

0.5168

1.6625

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

Q08881

ITK

TyrosineNoneprotein kinase ITK/TSK

Predicted

0.1635

0.5545

0.422

1.6127

Q00535

CDK5

CyclinNonedependentNonelike kinase 5

Predicted

0.1992

0.6633

0.2994

1.7256

P22694

PRKACB

cAMPNonedependent protein kinase catalytic subunit beta

Predicted

0.3737

0.2984

1.7836

Q13418

ILK

IntegrinNonelinked protein kinase

Predicted

0.5885

0.0388

0.394

0.7658

PharmaCoNets of Antrafenine (SPCN: 76.89 )

Antrafenine regulated-network (SDN: 14.51)

Community members of Antrafenine (SDC: 5.30)

PharmaCoNets of Antrafenine (S_PCN: 76.89 )

Antrafenine regulated-network (S_DN: 14.51)

Community members of Antrafenine (S_DC: 5.30)