PharmaCoNets of Antazoline (SPCN: 80.27 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Antazolinehsa00030Pentose phosphate pathway1.08E-053P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Antazolinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Antazolinehsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Antazolinehsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Antazolinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Antazolinehsa00830Retinol metabolism4.25E-021P00325ADH1BMore
Antazolinehsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Antazolinehsa00970Aminoacyl-tRNA biosynthesis3.78E-022O95363, Q15046FARS2, KARSMore
Antazolinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Antazolinehsa01230Biosynthesis of amino acids2.22E-034P51854, P60891, Q99707, P37837TKTL1, PRPS1, MTR, TALDO1More
Antazolinehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Antazolinehsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Antazolinehsa03013RNA transport2.35E-0510O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3More
Antazolinehsa03015mRNA surveillance pathway1.37E-036Q13362, Q14738, O94913, Q9UBU9, Q9H307, Q13148PPP2R5C, PPP2R5D, PCF11, NXF1, PNN, TARDBPMore
Antazolinehsa03020RNA polymerase3.00E-023P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Antazolinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Antazolinehsa03040Spliceosome1.28E-0513O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Antazolinehsa03050Proteasome1.21E-021P28074PSMB5More
Antazolinehsa03060Protein export4.42E-022P37108, Q15005SRP14, SPCS2More
Antazolinehsa04014Ras signaling pathway2.36E-028P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Antazolinehsa04015Rap1 signaling pathway1.79E-028P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1More
Antazolinehsa04020Calcium signaling pathway1.39E-024P30679, O15399, P07550, P23634GNA15, GRIN2D, ADRB2, ATP2B4More
Antazolinehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Antazolinehsa04062Chemokine signaling pathway5.65E-0414P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5More
Antazolinehsa04064NF-kappa B signaling pathway1.69E-0311P14778, P01584, P19174, Q04759, P06239, P63279, Q8NHW4, P09341, P19875, Q06643, Q9NQC7IL1R1, IL1B, PLCG1, PRKCQ, LCK, UBE2I, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Antazolinehsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Antazolinehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Antazolinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Antazolinehsa04114Oocyte meiosis3.65E-023P0DP23, Q13362, Q14738CALM1, PPP2R5C, PPP2R5DMore
Antazolinehsa04120Ubiquitin mediated proteolysis3.42E-036Q14145, Q13042, P30260, Q13191, P62837, Q15751KEAP1, CDC16, CDC27, CBLB, UBE2D2, HERC1More
Antazolinehsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Antazolinehsa04142Lysosome1.46E-027P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Antazolinehsa04144Endocytosis1.67E-028P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12More
Antazolinehsa04151PI3K-Akt signaling pathway3.70E-0212P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3More
Antazolinehsa04152AMPK signaling pathway1.83E-023Q96RR4, Q13362, Q14738CAMKK2, PPP2R5C, PPP2R5DMore
Antazolinehsa04213Longevity regulating pathway - multiple species2.70E-037P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Antazolinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Antazolinehsa04261Adrenergic signaling in cardiomyocytes3.75E-036P07550, P22694, P18848, Q13362, Q14738, P0DP23ADRB2, PRKACB, ATF4, PPP2R5C, PPP2R5D, CALM1More
Antazolinehsa04270Vascular smooth muscle contraction6.96E-036P0DP23, Q08828, P51828, P35579, P35749, P35318CALM1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Antazolinehsa04360Axon guidance4.04E-026P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Antazolinehsa04371Apelin signaling pathway1.00E-027P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Antazolinehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Antazolinehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Antazolinehsa04623Cytosolic DNA-sensing pathway1.65E-022P01584, Q8NHW4IL1B, CCL4L2More
Antazolinehsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Antazolinehsa04650Natural killer cell mediated cytotoxicity5.49E-0612P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, Q14953, P26715PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KIR2DS5, KLRC1More
Antazolinehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Antazolinehsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Antazolinehsa04659Th17 cell differentiation9.05E-0511Q04759, P19174, P06239, P14784, P14778, Q9UL17, P84022, Q13485, P08238, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, SMAD3, SMAD4, HSP90AB1, CD3E, CD247More
Antazolinehsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Antazolinehsa04662B cell receptor signaling pathway1.74E-025P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Antazolinehsa04664Fc epsilon RI signaling pathway2.47E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Antazolinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Antazolinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Antazolinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Antazolinehsa04728Dopaminergic synapse2.66E-023Q13362, Q14738, P0DP23PPP2R5C, PPP2R5D, CALM1More
Antazolinehsa04750Inflammatory mediator regulation of TRP channels7.85E-049P14778, P01584, Q08828, P51828, P19174, P42338, P24723, Q04759, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1More
Antazolinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Antazolinehsa04915Estrogen signaling pathway3.17E-025Q08828, P51828, P0DMV8, P0DP23, Q15788ADCY1, ADCY7, HSPA1A, CALM1, NCOA1More
Antazolinehsa04921Oxytocin signaling pathway3.13E-023P0DP23, Q96RR4, Q13469CALM1, CAMKK2, NFATC2More
Antazolinehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Antazolinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Antazolinehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Antazolinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Antazolinehsa04932Non-alcoholic fatty liver disease7.01E-0511P01375, P49841, O43521, P48023, O75460, P01584, P13073, P12074, Q16718, O95298, O14521TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHDMore
Antazolinehsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Antazolinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Antazolinehsa04970Salivary secretion2.43E-036P07550, Q08828, P51828, P22694, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, CALM1, CAMPMore
Antazolinehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Antazolinehsa04976Bile secretion3.14E-035O43315, Q08828, P51828, P08183, Q14032AQP9, ADCY1, ADCY7, ABCB1, BAATMore
Antazolinehsa04979Cholesterol metabolism1.61E-022P38571, P61916LIPA, NPC2More
Antazolinehsa05016Huntington disease2.46E-029O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12More
Antazolinehsa05017Spinocerebellar ataxia2.43E-021P28074PSMB5More
Antazolinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Antazolinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Antazolinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Antazolinehsa05033Nicotine addiction1.22E-022P28472, O15399GABRB3, GRIN2DMore
Antazolinehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Antazolinehsa05134Legionellosis8.80E-047P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2More
Antazolinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Antazolinehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Antazolinehsa05146Amoebiasis2.05E-0511P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, P22694, P12814CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1More
Antazolinehsa05150Staphylococcus aureus infection1.91E-024Q14532, P59665, P59666, P49913KRT32, DEFA1; DEFA1B, DEFA3, CAMPMore
Antazolinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Antazolinehsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Antazolinehsa05163Human cytomegalovirus infection3.31E-027P0DP23, Q8NHW4, Q08828, P51828, P23458, P01584, Q13651CALM1, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, IL10RAMore
Antazolinehsa05167Kaposi sarcoma-associated herpesvirus infection4.82E-023P23458, Q13469, P0DP23JAK1, NFATC2, CALM1More
Antazolinehsa05168Herpes simplex virus 1 infection4.79E-028P25963, Q07955, Q01130, Q9Y2A4, P51522, P17038, P52738, O75820NFKBIA, SFRS1, SFRS2, ZNF443, ZNF83, ZNF43, ZNF140, ZNF189More
Antazolinehsa05200Pathways in cancer9.46E-0317Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RBMore
Antazolinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Antazolinehsa05212Pancreatic cancer5.06E-036P42338, Q15311, P23458, P84022, Q13485, O75293PIK3CB, RALBP1, JAK1, SMAD3, SMAD4, GADD45BMore
Antazolinehsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Antazolinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Antazolinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Antazolinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Antazolinehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Antazolinehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Antazoline (SDC: 5.73)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P30679GNA15Guanine nucleotideNonebinding protein subunit alphaNone15Predicted00.03730.11460.28910.5369
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q9Y2I1NISCHNischarinPredicted10.60820.225100.7543
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)