PharmaCoNets

PharmaCoNets of Anileridine (S_PCN: 85.20 )

Anileridine regulated-network (S_DN: 15.90)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Anileridine

hsa00030

Pentose phosphate pathway

1.69E-02

P60891, P37837

PRPS1, TALDO1

Anileridine

hsa00052

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Anileridine

hsa00071

Fatty acid degradation

4.66E-02

O75521, P11766, P33121

ECI2, ADH5, ACSL1

Anileridine

hsa00190

Oxidative phosphorylation

5.12E-04

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Anileridine

hsa00240

Pyrimidine metabolism

4.29E-02

P21589, P04183

NT5E, TK1

Anileridine

hsa00500

Starch and sucrose metabolism

5.45E-05

O43451, P46976, P06737

MGAM, GYG1, PYGL

Anileridine

hsa00513

Various types of N-glycan biosynthesis

4.96E-02

Q9NR34

MAN1C1

Anileridine

hsa00520

Amino sugar and nucleotide sugar metabolism

2.11E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Anileridine

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Anileridine

hsa00564

Glycerophospholipid metabolism

4.29E-02

Q6P1A2, P23743

MBOAT5, DGKA

Anileridine

hsa00603

Glycosphingolipid biosynthesis - globo and isoglobo series

8.72E-03

P06865, O75752

HEXA, B3GALNT1

Anileridine

hsa00604

Glycosphingolipid biosynthesis - ganglio series

2.46E-02

P06865, Q9H4F1

HEXA, ST6GALNAC4

Anileridine

hsa00730

Thiamine metabolism

7.19E-04

P05186, P24666

ALPL, ACP1

Anileridine

hsa00770

Pantothenate and CoA biosynthesis

2.26E-04

O95498, O95497, Q9NRN7

VNN2, VNN1, AASDHPPT

Anileridine

hsa00860

Porphyrin and chlorophyll metabolism

1.69E-02

P36551, P30043

CPOX, BLVRB

Anileridine

hsa00970

Aminoacyl-tRNA biosynthesis

1.58E-04

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Anileridine

hsa00983

Drug metabolism - other enzymes

2.44E-02

P32320, P05164

CDA, MPO

Anileridine

hsa01230

Biosynthesis of amino acids

3.59E-02

P60891, Q99707, P37837

PRPS1, MTR, TALDO1

Anileridine

hsa01240

Biosynthesis of cofactors

2.52E-02

Q9BQB6, P14550

VKORC1, AKR1A1

Anileridine

hsa01523

Antifolate resistance

3.80E-02

Q92820, P04818

GGH, TYMS

Anileridine

hsa02010

ABC transporters

2.29E-02

P45844, P08183

ABCG1, ABCB1

Anileridine

hsa03008

Ribosome biogenesis in eukaryotes

2.03E-03

Q9NYH9, O14980, O60832, P78345, Q9BVP2

UTP6, XPO1, DKC1, RPP38, GNL3

Anileridine

hsa03013

RNA transport

1.20E-07

O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, P23588, Q9Y6A5, P51114

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, EIF4B, TACC3, FXR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
P21462	FPR1	fMet-Leu-Phe receptor	O14980	XPO1	Exportin-1	-0.742
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
P21462	FPR1	fMet-Leu-Phe receptor	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.874
P51684	CCR6	C-C chemokine receptor type 6	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.924
P21462	FPR1	fMet-Leu-Phe receptor	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	-0.78
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
P21462	FPR1	fMet-Leu-Phe receptor	O14893	GEMIN2	Gem-associated protein 2	-0.87
P51684	CCR6	C-C chemokine receptor type 6	O14893	GEMIN2	Gem-associated protein 2	0.771
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
P21462	FPR1	fMet-Leu-Phe receptor	P61326	MAGOH	Protein mago nashi homolog	-0.835
P51684	CCR6	C-C chemokine receptor type 6	P61326	MAGOH	Protein mago nashi homolog	0.704
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
P21462	FPR1	fMet-Leu-Phe receptor	Q7Z3B4	NUP54	Nucleoporin p54	-0.903
P51684	CCR6	C-C chemokine receptor type 6	Q7Z3B4	NUP54	Nucleoporin p54	0.811
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
P21462	FPR1	fMet-Leu-Phe receptor	P35658	NUP214	Nuclear pore complex protein Nup214	0.971
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
P21462	FPR1	fMet-Leu-Phe receptor	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.89
P51684	CCR6	C-C chemokine receptor type 6	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.701
P21462	FPR1	fMet-Leu-Phe receptor	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.953
P51684	CCR6	C-C chemokine receptor type 6	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.711
P51684	CCR6	C-C chemokine receptor type 6	P78345	RPP38	Ribonuclease P protein subunit p38	0.861
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
P21462	FPR1	fMet-Leu-Phe receptor	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	-0.721
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P21462	FPR1	fMet-Leu-Phe receptor	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.904
P51684	CCR6	C-C chemokine receptor type 6	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.732
P21462	FPR1	fMet-Leu-Phe receptor	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	-0.713

Anileridine

hsa03020

RNA polymerase

9.86E-07

Q9GZM3, P52435

POLR2J2, POLR2J

Anileridine

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Anileridine

hsa03410

Base excision repair

2.52E-02

P49005, P29372

POLD2, MPG

Anileridine

hsa04015

Rap1 signaling pathway

3.07E-02

P25116, Q8TEU7, P08514, P17252

F2R, RAPGEF6, ITGA2B, PRKCA

Anileridine

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.48E-02

P09341, P19875, P25024, P25025, P14784

CXCL1, CXCL2, CXCR1, CXCR2, IL2RB

Anileridine

hsa04062

Chemokine signaling pathway

2.43E-04

P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P49407, Q08881, P49841

CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, ARRB1, ITK, GSK3B

Anileridine

hsa04064

NF-kappa B signaling pathway

3.08E-03

P10415, P51617, Q13546, P14778, P19174, Q04759, Q9UDY8, Q13077, P06239, P24522, P09341, P19875, Q06643

BCL2, IRAK1, RIPK1, IL1R1, PLCG1, PRKCQ, MALT1, TRAF1, LCK, GADD45A, CXCL1, CXCL2, LTB

Anileridine

hsa04070

Phosphatidylinositol signaling system

4.07E-02

P0DP23, Q14643, O14732, P17252

CALM1, ITPR1, IMPA2, PRKCA

Anileridine

hsa04071

Sphingolipid signaling pathway

1.82E-04

P17252, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415, Q9UQC2

PRKCA, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2, GAB2

Anileridine

hsa04072

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Anileridine

hsa04110

Cell cycle

6.80E-03

P06493, O75293, P30304, P33981, P42773, P01106

CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC

Anileridine

hsa04114

Oocyte meiosis

2.05E-02

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Anileridine

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Anileridine

hsa04136

Autophagy - other

5.92E-03

O94817, Q9H1Y0

ATG12, ATG5

Anileridine

hsa04210

Apoptosis

3.58E-02

O76075, P01375, Q9NR28, Q16548

DFFB, TNF, DIABLO, BCL2A1

Anileridine

hsa04213

Longevity regulating pathway - multiple species

3.85E-02

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Anileridine

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Anileridine

hsa04217

Necroptosis

2.24E-04

P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752

TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPID

Anileridine

hsa04218

Cellular senescence

4.79E-02

P01106, O75293, P30304, P06493

MYC, GADD45B, CDC25A, CDK1

Anileridine

hsa04261

Adrenergic signaling in cardiomyocytes

3.44E-02

Q16537, P0DP23, P17252, P10415, P20020

PPP2R5E, CALM1, PRKCA, BCL2, ATP2B1

Anileridine

hsa04340

Hedgehog signaling pathway

3.32E-02

P49841, P22694

GSK3B, PRKACB

Anileridine

hsa04350

TGF-beta signaling pathway

4.88E-02

P37173

TGFBR2

Anileridine

hsa04370

VEGF signaling pathway

1.29E-02

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Anileridine

hsa04390

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Anileridine

hsa04610

Complement and coagulation cascades

2.78E-03

P0C0L4

C4A

Anileridine

hsa04611

Platelet activation

3.39E-02

P25116, P08514, P07359

F2R, ITGA2B, GP1BA

Anileridine

hsa04612

Antigen processing and presentation

1.51E-02

P13765, P48382, P26715, P26717, Q13241, O43908, P01732

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A

Anileridine

hsa04613

Neutrophil extracellular trap formation

2.23E-03

P17252, O60603, P08246, Q92769, P04908, Q6FI13, Q93077, P33778, P68431, P14598, Q15080, P21462, O43315, Q16539

PRKCA, TLR2, ELA2, HDAC2, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC3, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1, AQP9, MAPK14

Anileridine

hsa04614

Renin-angiotensin system

1.52E-02

P50052

AGTR2

Anileridine

hsa04623

Cytosolic DNA-sensing pathway

3.15E-02

P01568, P25963

IFNA21, NFKBIA

Anileridine

hsa04640

Hematopoietic cell lineage

1.54E-03

P21926, P14778, P27930, P11215, P25063, P07766, P01732, P01730, P09564

CD9, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD4, CD7

Anileridine

hsa04650

Natural killer cell mediated cytotoxicity

6.78E-07

P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, P26715

PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721

Anileridine

hsa04657

IL-17 signaling pathway

3.31E-02

P49841, P14780, P01375

GSK3B, MMP9, TNF

Anileridine

hsa04658

Th1 and Th2 cell differentiation

2.21E-04

Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761

PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3

Anileridine

hsa04659

Th17 cell differentiation

1.43E-04

P25963, Q04759, P19174, P06239, P14784, P14778, Q9UL17, P84022, Q13485, P07766, P20963

NFKBIA, PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, SMAD3, SMAD4, CD3E, CD247

Anileridine

hsa04660

T cell receptor signaling pathway

2.21E-05

P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823

Anileridine

hsa04666

Fc gamma R-mediated phagocytosis

2.22E-02

P49006, P06396, P14598, P17252

MARCKSL1, GSN, NCF1, PRKCA

Anileridine

hsa04672

Intestinal immune network for IgA production

1.35E-02

P29965, P13765

CD40LG, HLA-DOB

Anileridine

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Anileridine

hsa04720

Long-term potentiation

4.42E-02

P17252, P0DP23, Q14643

PRKCA, CALM1, ITPR1

Anileridine

hsa04721

Synaptic vesicle cycle

3.15E-02

Q13488, P31645

TCIRG1, SLC6A4

Anileridine

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Anileridine

hsa04728

Dopaminergic synapse

2.82E-02

P14416, P63218, P50151, P49841, Q16539, P49407

DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1

Anileridine

hsa04750

Inflammatory mediator regulation of TRP channels

7.24E-03

P14778, P19174, P42338, P24723, Q04759

IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ

Anileridine

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Anileridine

hsa04912

GnRH signaling pathway

4.42E-02

P17252, Q14643, P0DP23

PRKCA, ITPR1, CALM1

Anileridine

hsa04914

Progesterone-mediated oocyte maturation

2.66E-02

Q17RY0, Q9Y6D9, P51812, Q02750

CPEB4, MAD1L1, RPS6KA3, MAP2K1

Anileridine

hsa04918

Thyroid hormone synthesis

3.16E-02

P17252, P27824

PRKCA, CANX

Anileridine

hsa04919

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Anileridine

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Anileridine

hsa04925

Aldosterone synthesis and secretion

1.54E-02

Q14643, P0DP23, P17252, P20020

ITPR1, CALM1, PRKCA, ATP2B1

Anileridine

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Anileridine

hsa04932

Non-alcoholic fatty liver disease

2.44E-03

P01375, P49841, P48023, Q16718, O14521

TNF, GSK3B, FASLG, NDUFA5, SDHD

Anileridine

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.25E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Anileridine

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Anileridine

hsa04966

Collecting duct acid secretion

3.15E-02

P02730, Q9Y666

SLC4A1, SLC12A7

Anileridine

hsa04970

Salivary secretion

1.00E-02

Q14643, P20020, P17252, P0DP23

ITPR1, ATP2B1, PRKCA, CALM1

Anileridine

hsa04972

Pancreatic secretion

1.00E-02

Q14643, P20020, P17252

ITPR1, ATP2B1, PRKCA

Anileridine

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Anileridine

hsa04975

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Anileridine

hsa04976

Bile secretion

1.67E-03

O43315, P22694, P08183

AQP9, PRKACB, ABCB1

Anileridine

hsa05016

Huntington disease

2.46E-05

Q9GZM3, P52435, Q9NYC9

POLR2J2, POLR2J, DNAH9

Anileridine

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Anileridine

hsa05022

Pathways of neurodegeneration - multiple diseases

1.24E-02

P49841, Q16718, O14521, Q13561, Q16539, Q08752

GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPID

Anileridine

hsa05100

Bacterial invasion of epithelial cells

4.50E-02

Q92529

SHC3

Anileridine

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.62E-04

Q16539, P09341, P19875, P19174, P25024, P25025, P07948

MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN

Anileridine

hsa05132

Salmonella infection

7.99E-05

P51617, P25963, Q9UJU2, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509

IRAK1, NFKBIA, LEF1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3

Anileridine

hsa05133

Pertussis

4.94E-02

P0C0L4

C4A

Anileridine

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Anileridine

hsa05135

Yersinia infection

4.65E-02

P13612, P06239, Q16539, P01375, P49841

ITGA4, LCK, MAPK14, TNF, GSK3B

Anileridine

hsa05140

Leishmaniasis

6.62E-04

P14598, P42224, O60603, P25963, P29350, P49006, P51617, Q15080

NCF1, STAT1, TLR2, NFKBIA, PTPN6, MARCKSL1, IRAK1, NCF4

Anileridine

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Anileridine

hsa05144

Malaria

1.64E-03

P60033, O60603, P01375, P35443, P26718

CD81, TLR2, TNF, THBS4, KLRK1

Anileridine

hsa05145

Toxoplasmosis

2.78E-02

P25963, P10415, Q13489

NFKBIA, BCL2, BIRC3

Anileridine

hsa05146

Amoebiasis

2.21E-04

P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814

CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1

Anileridine

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Anileridine

hsa05161

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Anileridine

hsa05163

Human cytomegalovirus infection

1.72E-02

P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463

TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5

Anileridine

hsa05168

Herpes simplex virus 1 infection

3.38E-03

P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212

Anileridine

hsa05169

Epstein-Barr virus infection

2.54E-02

Q92769, P04637, Q13546, P10415, P24522, O60603, P51617, P09693

HDAC2, TP53, RIPK1, BCL2, GADD45A, TLR2, IRAK1, CD3G

Anileridine

hsa05170

Human immunodeficiency virus 1 infection

6.54E-03

P0DP23, P17252, Q13546, Q14643, P51617, O60603, P09693, P10415, Q9Y6Q5

CALM1, PRKCA, RIPK1, ITPR1, IRAK1, TLR2, CD3G, BCL2, AP1M2

Anileridine

hsa05205

Proteoglycans in cancer

4.46E-02

Q12955, Q14247, P17252, P08962

ANK3, CTTN, PRKCA, CD63

Anileridine

hsa05210

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Anileridine

hsa05212

Pancreatic cancer

4.21E-03

P37173, P84022, Q13485

TGFBR2, SMAD3, SMAD4

Anileridine

hsa05214

Glioma

1.00E-02

P0DP23, P17252, P04637, P24522

CALM1, PRKCA, TP53, GADD45A

Anileridine

hsa05216

Thyroid cancer

1.58E-03

P01106, Q9UJU2, P04637, P24522, O75293

MYC, LEF1, TP53, GADD45A, GADD45B

Anileridine

hsa05217

Basal cell carcinoma

4.42E-02

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Anileridine

hsa05220

Chronic myeloid leukemia

1.25E-02

Q13485, P25963, P84022

SMAD4, NFKBIA, SMAD3

Anileridine

hsa05222

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Anileridine

hsa05223

Non-small cell lung cancer

1.39E-02

P10826, Q9HC35, O75293

RARB, EML4, GADD45B

Anileridine

hsa05226

Gastric cancer

2.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Anileridine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

2.99E-04

P42338, P19174, P07766, P20963, P06239, Q04759, Q9HC35, P01730

PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQ, EML4, CD4

Anileridine

hsa05310

Asthma

1.35E-02

P13765, P29965

HLA-DOB, CD40LG

Anileridine

hsa05320

Autoimmune thyroid disease

3.16E-02

P13765, P29965

HLA-DOB, CD40LG

Anileridine

hsa05330

Allograft rejection

1.76E-03

P13765, P29965, P48023, P01375

HLA-DOB, CD40LG, FASLG, TNF

Anileridine

hsa05332

Graft-versus-host disease

3.70E-02

P48023, P01375

FASLG, TNF

Anileridine

hsa05340

Primary immunodeficiency

1.28E-03

P01730, P11912, P07766, P06239

CD4, CD79A, CD3E, LCK

Anileridine

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

1.82E-02

P14923, P08514, Q9UJU2

JUP, ITGA2B, LEF1

Anileridine

hsa05415

Diabetic cardiomyopathy

4.54E-04

P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406

PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDH

Anileridine

hsa05416

Viral myocarditis

4.29E-02

P13765, P29965

HLA-DOB, CD40LG

Anileridine

hsa05418

Fluid shear stress and atherosclerosis

3.61E-02

Q16539, P10599, P14780, P01375, P14778, P27930

MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2

Community members of Anileridine (S_DC: 5.36)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

KCNA3

Potassium voltageNonegated channel subfamily A member 3

Predicted

0.1396

0.5055

1.0809

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P30531

SLC6A1

SodiumNone and chlorideNonedependent GABA transporter 1

Predicted

0.0889

0.5202

0.1047

1.1894

O75469

NR1I2

Nuclear receptor subfamily 1 group I member 2

Predicted

0.0315

0.9493

1.9143

P08183

ABCB1

ATPNonedependent translocase ABCB1

Predicted

0.0788

0.2052

2.2446

Q92769

HDAC2

Histone deacetylase 2

Predicted

0.0473

0.986

3.0097

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P09960

LTA4H

Leukotriene ANone4 hydrolase

Predicted

0.277

0.9519

0.1565

2.1988

Q02750

MAP2K1

Dual specificity mitogenNoneactivated protein kinase kinase 1

Predicted

0.312

0.5129

2.1819

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P25116

F2R

ProteinaseNoneactivated receptor 1

Predicted

0.2038

0.3196

0.5136

1.2547

P52732

KIF11

KinesinNonelike protein KIF11

Predicted

0.0082

0.8281

1.6602

P21462

FPR1

fMetNoneLeuNonePhe receptor

Predicted

0.1205

0.3492

0.4378

1.1964

P25025

CXCR2

CNoneXNoneC chemokine receptor type 2

Predicted

0.0278

0.5189

0.4494

1.5011

P25024

CXCR1

CNoneXNoneC chemokine receptor type 1

Predicted

0.1656

0.4232

0.4009

1.33

P50052

AGTR2

TypeNone2 angiotensin II receptor

Predicted

0.0604

0.4365

0.1541

1.0572

P51684

CCR6

CNoneC chemokine receptor type 6

Predicted

0.085

0.1741

0.3304

0.7212

PharmaCoNets of Anileridine (SPCN: 85.20 )

Anileridine regulated-network (SDN: 15.90)

Community members of Anileridine (SDC: 5.36)

PharmaCoNets of Anileridine (S_PCN: 85.20 )

Anileridine regulated-network (S_DN: 15.90)

Community members of Anileridine (S_DC: 5.36)