PharmaCoNets of Amylocaine (SPCN: 57.61 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Amylocainehsa00071Fatty acid degradation4.66E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Amylocainehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Amylocainehsa00500Starch and sucrose metabolism2.61E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Amylocainehsa00600Sphingolipid metabolism4.77E-023Q9BX95, O14494, P06280SGPP1, PLPP1, GLAMore
Amylocainehsa00630Glyoxylate and dicarboxylate metabolism2.48E-022P40926, P15104MDH2, GLULMore
Amylocainehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Amylocainehsa00970Aminoacyl-tRNA biosynthesis1.17E-023O95363, P14868, Q15046FARS2, DARS, KARSMore
Amylocainehsa00983Drug metabolism - other enzymes4.77E-023P04183, P32320, P05164TK1, CDA, MPOMore
Amylocainehsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Amylocainehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Amylocainehsa03010Ribosome1.53E-058P62753, P62906, P46776, Q07020, P61513, P27635, P62249, P23396RPS6, RPL10A, RPL27A, RPL18, RPL37A, RPL10, RPS16, RPS3More
Amylocainehsa03013RNA transport2.12E-029P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Amylocainehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Amylocainehsa03040Spliceosome1.46E-024P17844, P51991, P61978, P11142DDX5, HNRPA3, HNRPK, HSPA8More
Amylocainehsa03050Proteasome3.93E-021P62195PSMC5More
Amylocainehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Amylocainehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Amylocainehsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Amylocainehsa04071Sphingolipid signaling pathway4.66E-025P17252, P21453, Q13362, Q9BX95, P10415PRKCA, S1PR1, PPP2R5C, SGPP1, BCL2More
Amylocainehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Amylocainehsa04110Cell cycle6.63E-046P06493, O60566, P30304, P33981, P42773, P01106CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYCMore
Amylocainehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Amylocainehsa04141Protein processing in endoplasmic reticulum2.82E-048P18848, Q15437, Q15436, Q99941, P11142, P07900, Q9NR31, P14625ATF4, SEC23B, SEC23A, CREBL1, HSPA8, HSP90AA1, SAR1A, HSP90B1More
Amylocainehsa04145Phagosome3.82E-038Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4More
Amylocainehsa04151PI3K-Akt signaling pathway4.12E-049P62753, P27348, P07900, P14625, Q16363, P22105, Q99941, P18848, O00141RPS6, YWHAQ, HSP90AA1, HSP90B1, LAMA4, TNXB, CREBL1, ATF4, SGKMore
Amylocainehsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Amylocainehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Amylocainehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Amylocainehsa04261Adrenergic signaling in cardiomyocytes1.46E-024P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Amylocainehsa04612Antigen processing and presentation1.51E-027P13765, P48382, P26715, P26717, Q13241, O43908, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8AMore
Amylocainehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Amylocainehsa04640Hematopoietic cell lineage2.18E-039P14778, P27930, P11215, P25063, P07766, P01732, P01730, P06127, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD4, CD5, CD7More
Amylocainehsa04650Natural killer cell mediated cytotoxicity1.26E-0412P19174, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, P26715PLCG1, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Amylocainehsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Amylocainehsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Amylocainehsa04660T cell receptor signaling pathway2.24E-0413Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Amylocainehsa04714Thermogenesis6.01E-048Q16539, P51828, P62753, P33121, P12074, O15239, Q16718, O14521MAPK14, ADCY7, RPS6, ACSL1, COX6A1, NDUFA1, NDUFA5, SDHDMore
Amylocainehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Amylocainehsa04725Cholinergic synapse2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Amylocainehsa04728Dopaminergic synapse4.78E-023Q99941, P18848, Q13557CREBL1, ATF4, CAMK2DMore
Amylocainehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Amylocainehsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Amylocainehsa04912GnRH signaling pathway2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Amylocainehsa04915Estrogen signaling pathway2.75E-035Q99941, P18848, P51828, P07900, P11142CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8More
Amylocainehsa04918Thyroid hormone synthesis1.98E-045P51828, Q99941, P18848, P14625, P02768ADCY7, CREBL1, ATF4, HSP90B1, ALBMore
Amylocainehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Amylocainehsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Amylocainehsa04926Relaxin signaling pathway3.34E-023Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Amylocainehsa04927Cortisol synthesis and secretion4.16E-033Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Amylocainehsa04928Parathyroid hormone synthesis, secretion and action2.17E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Amylocainehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Amylocainehsa04934Cushing syndrome1.12E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Amylocainehsa04935Growth hormone synthesis, secretion and action2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Amylocainehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Amylocainehsa04961Endocrine and other factor-regulated calcium reabsorption2.68E-023P20020, Q9UEF7, P17252ATP2B1, KL, PRKCAMore
Amylocainehsa04972Pancreatic secretion2.68E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Amylocainehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Amylocainehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Amylocainehsa05010Alzheimer disease1.23E-022P17861, P62195XBP1, PSMC5More
Amylocainehsa05012Parkinson disease7.44E-032P17861, P62195XBP1, PSMC5More
Amylocainehsa05014Amyotrophic lateral sclerosis2.32E-043P17861, P62195, Q53GS7XBP1, PSMC5, GLE1More
Amylocainehsa05017Spinocerebellar ataxia1.95E-032P17861, P62195XBP1, PSMC5More
Amylocainehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Amylocainehsa05022Pathways of neurodegeneration - multiple diseases3.76E-038P49841, Q16718, O14521, P17861, Q13561, Q16539, Q08752, P62195GSK3B, NDUFA5, SDHD, XBP1, DCTN2, MAPK14, PPID, PSMC5More
Amylocainehsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Amylocainehsa05031Amphetamine addiction6.41E-033Q13557, Q99941, P18848CAMK2D, CREBL1, ATF4More
Amylocainehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Amylocainehsa05132Salmonella infection4.62E-0311P51617, Q9UJU2, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371IRAK1, LEF1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Amylocainehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Amylocainehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Amylocainehsa05144Malaria3.30E-024P60033, O60603, P35443, P26718CD81, TLR2, THBS4, KLRK1More
Amylocainehsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Amylocainehsa05152Tuberculosis1.08E-028Q13488, P48382, P25208, O60603, P10415, P01568, Q9UDY8, P51617TCIRG1, RFX5, NFYB, TLR2, BCL2, IFNA21, MALT1, IRAK1More
Amylocainehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Amylocainehsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Amylocainehsa05170Human immunodeficiency virus 1 infection2.25E-0210P62873, P17252, Q13546, Q14643, P01568, P51617, O60603, Q13315, P10415, Q9Y6Q5GNB1, PRKCA, RIPK1, ITPR1, IFNA21, IRAK1, TLR2, ATM, BCL2, AP1M2More
Amylocainehsa05171Coronavirus disease - COVID-194.36E-058P23396, P62753, P62249, P62906, P27635, Q07020, P46776, P61513RPS3, RPS6, RPS16, RPL10A, RPL10, RPL18, RPL27A, RPL37AMore
Amylocainehsa05202Transcriptional misregulation in cancer1.61E-0211Q12778, Q15532, Q13315, P14780, P14923, Q13489, Q13077, P35226, P05164, P08246, Q9C0K0FOXO1, SS18, ATM, MMP9, JUP, BIRC3, TRAF1, BMI1, MPO, ELA2, BCL11BMore
Amylocainehsa05203Viral carcinogenesis1.46E-024Q99941, P18848, P27348, P61978CREBL1, ATF4, YWHAQ, HNRPKMore
Amylocainehsa05205Proteoglycans in cancer1.67E-029Q13009, Q14643, O75369, P14780, P17252, O60603, P04628, Q13635, P08962TIAM1, ITPR1, FLNB, MMP9, PRKCA, TLR2, WNT1, PTCH1, CD63More
Amylocainehsa05215Prostate cancer4.48E-022P18848, P14625ATF4, HSP90B1More
Amylocainehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Amylocainehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Amylocainehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Amylocainehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Amylocaine (SDC: 4.55)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
Q9UDY8MALT1MucosaNoneassociated lymphoid tissue lymphoma translocation protein 1Predicted10.05160.1470.55920.8789
P14625HSP90B1EndoplasminPredicted00.23360.14970.53840.9546
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P17861XBP1XNoneboxNonebinding protein 1Predicted00.29140.06510.46080.7367
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)