PharmaCoNets

PharmaCoNets of Amsacrine (S_PCN: 266.53 )

Amsacrine regulated-network (S_DN: 26.44)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Amsacrine

hsa00030

Pentose phosphate pathway

6.58E-05

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Amsacrine

hsa00040

Pentose and glucuronate interconversions

4.00E-02

P15121

AKR1B1

Amsacrine

hsa00052

Galactose metabolism

1.06E-03

P06280, O43451

GLA, MGAM

Amsacrine

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Amsacrine

hsa00071

Fatty acid degradation

3.10E-03

O75521, P00325, P11766, P33121

ECI2, ADH1B, ADH5, ACSL1

Amsacrine

hsa00120

Primary bile acid biosynthesis

3.72E-02

P22680, P22307

CYP7A1, SCP2

Amsacrine

hsa00220

Arginine biosynthesis

4.40E-02

P15104

GLUL

Amsacrine

hsa00340

Histidine metabolism

4.52E-02

O95954

FTCD

Amsacrine

hsa00500

Starch and sucrose metabolism

3.12E-09

O43451, P46976, P35573, P06737

MGAM, GYG1, AGL, PYGL

Amsacrine

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Amsacrine

hsa00513

Various types of N-glycan biosynthesis

4.83E-02

Q9NR34

MAN1C1

Amsacrine

hsa00520

Amino sugar and nucleotide sugar metabolism

1.04E-03

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Amsacrine

hsa00564

Glycerophospholipid metabolism

9.70E-03

Q9Y259, P49619

CHKB, DGKG

Amsacrine

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Amsacrine

hsa00603

Glycosphingolipid biosynthesis - globo and isoglobo series

8.72E-03

P06865, O75752

HEXA, B3GALNT1

Amsacrine

hsa00604

Glycosphingolipid biosynthesis - ganglio series

2.46E-02

P06865, Q9H4F1

HEXA, ST6GALNAC4

Amsacrine

hsa00630

Glyoxylate and dicarboxylate metabolism

8.35E-06

P40925, P40926, P15104

MDH1, MDH2, GLUL

Amsacrine

hsa00640

Propanoate metabolism

3.83E-02

Q02252, Q9P2R7

ALDH6A1, SUCLA2

Amsacrine

hsa00670

One carbon pool by folate

1.33E-02

P04818, Q99707

TYMS, MTR

Amsacrine

hsa00730

Thiamine metabolism

1.87E-06

P05186, P24666

ALPL, ACP1

Amsacrine

hsa00740

Riboflavin metabolism

4.77E-02

P30043

BLVRB

Amsacrine

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Amsacrine

hsa00790

Folate biosynthesis

2.02E-02

P15121

AKR1B1

Amsacrine

hsa00830

Retinol metabolism

2.20E-02

P00325, P11766, Q9BPW9, O75911

ADH1B, ADH5, DHRS9, DHRS3

Amsacrine

hsa00860

Porphyrin and chlorophyll metabolism

1.69E-02

P36551, P30043

CPOX, BLVRB

Amsacrine

hsa00920

Sulfur metabolism

3.18E-02

Q16762

TST

Amsacrine

hsa00970

Aminoacyl-tRNA biosynthesis

2.24E-05

O95363, P54136, Q15046

FARS2, RARS1, KARS

Amsacrine

hsa00980

Metabolism of xenobiotics by cytochrome P450

4.00E-02

P09211

GSTP1

Amsacrine

hsa00983

Drug metabolism - other enzymes

1.44E-05

P04183, P32320, P05164

TK1, CDA, MPO

Amsacrine

hsa01100

Metabolic pathways

6.99E-03

Q9NR34, Q9Y259, P05089, P32320, Q13956, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, P49619, O95954, Q9HCC0, P33121, Q02318, P57054, Q9UBX8, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P35573, P06737

MAN1C1, CHKB, ARG1, CDA, PDE6H, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, DGKG, FTCD, MCCC2, ACSL1, CYP27A1, PIGP, B4GALT6, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, AGL, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
P11388	TOP2A	DNA topoisomerase 2-alpha	Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0.703
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P11388	TOP2A	DNA topoisomerase 2-alpha	O95954	FTCD	Formimidoyltransferase-cyclodeaminase	-0.718
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
P11388	TOP2A	DNA topoisomerase 2-alpha	Q02318	CYP27A1	Sterol 26-hydroxylase, mitochondrial	-0.879
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBX8	B4GALT6	Beta-1,4-galactosyltransferase 6	0.869
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
P11388	TOP2A	DNA topoisomerase 2-alpha	P35573	AGL	Glycogen debranching enzyme	0.759
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Amsacrine

hsa01230

Biosynthesis of amino acids

2.92E-03

P51854, P60891, Q99707, P05089, P37837

TKTL1, PRPS1, MTR, ARG1, TALDO1

Amsacrine

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P04049

RAF1

Amsacrine

hsa01522

Endocrine resistance

2.13E-05

P14780, P22694, P04049, Q9UM47, P10415, Q13323

MMP9, PRKACB, RAF1, NOTCH3, BCL2, BIK

Amsacrine

hsa01523

Antifolate resistance

1.72E-04

P41440, Q92820, P04818, P01375

SLC19A1, GGH, TYMS, TNF

Amsacrine

hsa01524

Platinum drug resistance

5.74E-03

Q13489, P98170, P78417, P43246, P31751

BIRC3, BIRC4, GSTO1, MSH2, AKT2

Amsacrine

hsa02010

ABC transporters

2.17E-03

Q8IZY2

ABCA7

Amsacrine

hsa03008

Ribosome biogenesis in eukaryotes

2.03E-03

Q9NYH9, O14980, O60832, P78345, Q9BVP2

UTP6, XPO1, DKC1, RPP38, GNL3

Amsacrine

hsa03010

Ribosome

2.89E-06

P62753, P25398, P32969, P40429, P62829, Q07020, P62888, P18077, P61927, P61513, P36578, P27635, P05386, P62249

RPS6, RPS12, RPL9, RPL13A, RPL23, RPL18, RPL30, RPL35A, RPL37, RPL37A, RPL4, RPL10, RPLP1, RPS16

Amsacrine

hsa03013

RNA transport

5.11E-09

P62826, O14980, P52298, O14893, P61326, Q9UBU9, Q7Z3B4, P35658, P63279, P68104, Q14152, O75822, P78345, Q14240, Q9BZI7, P23588, Q9Y6A5, Q14232, Q06787

RAN, XPO1, NCBP2, GEMIN2, MAGOH, NXF1, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3J, RPP38, EIF4A2, UPF3B, EIF4B, TACC3, EIF2B1, FMR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62826	RAN	GTP-binding nuclear protein Ran	0.732
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
P51684	CCR6	C-C chemokine receptor type 6	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.924
P22748	CA4	Carbonic anhydrase 4	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.879
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
P49759	CLK1	Dual specificity protein kinase CLK1	O14893	GEMIN2	Gem-associated protein 2	0.76
P51684	CCR6	C-C chemokine receptor type 6	O14893	GEMIN2	Gem-associated protein 2	0.771
P22748	CA4	Carbonic anhydrase 4	O14893	GEMIN2	Gem-associated protein 2	-0.709
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
P51684	CCR6	C-C chemokine receptor type 6	P61326	MAGOH	Protein mago nashi homolog	0.704
P22748	CA4	Carbonic anhydrase 4	P61326	MAGOH	Protein mago nashi homolog	-0.822
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.79
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
P51684	CCR6	C-C chemokine receptor type 6	Q7Z3B4	NUP54	Nucleoporin p54	0.811
P22748	CA4	Carbonic anhydrase 4	Q7Z3B4	NUP54	Nucleoporin p54	-0.776
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
P22748	CA4	Carbonic anhydrase 4	P35658	NUP214	Nuclear pore complex protein Nup214	0.827
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q00535	CDK5	Cyclin-dependent-like kinase 5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.721
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
P51684	CCR6	C-C chemokine receptor type 6	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.701
P22748	CA4	Carbonic anhydrase 4	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.786
P51684	CCR6	C-C chemokine receptor type 6	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.711
P22748	CA4	Carbonic anhydrase 4	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.869
P51684	CCR6	C-C chemokine receptor type 6	P78345	RPP38	Ribonuclease P protein subunit p38	0.861
P22748	CA4	Carbonic anhydrase 4	P78345	RPP38	Ribonuclease P protein subunit p38	-0.731
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
P49759	CLK1	Dual specificity protein kinase CLK1	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.704
P49759	CLK1	Dual specificity protein kinase CLK1	Q9BZI7	UPF3B	Regulator of nonsense transcripts 3B	0.758
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P51684	CCR6	C-C chemokine receptor type 6	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.732
P22748	CA4	Carbonic anhydrase 4	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.912
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.749
P49759	CLK1	Dual specificity protein kinase CLK1	Q06787	FMR1	Synaptic functional regulator FMR1	0.793

Amsacrine

hsa03015

mRNA surveillance pathway

4.81E-02

Q9BZI7, O94913

UPF3B, PCF11

Amsacrine

hsa03020

RNA polymerase

1.31E-10

P30876, P24928, P62487, Q9GZM3, P52435, Q9Y535

POLR2B, POLR2A, POLR2G, POLR2J2, POLR2J, POLR3H

Amsacrine

hsa03040

Spliceosome

2.43E-09

Q14562, O43143, O60508, P17844, P08579, P26368, P51991, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX8, DHX15, CDC40, DDX5, SNRPB2, U2AF2, HNRPA3, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.708
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.809
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O60508	CDC40	Pre-mRNA-processing factor 17	-0.837
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.73
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.702
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P51991	HNRPA3	Heterogeneous nuclear ribonucleoprotein A3	0.787
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.827
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.879
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.806
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.703
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.709
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.761
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Amsacrine

hsa03050

Proteasome

4.83E-02

P55036

PSMD4

Amsacrine

hsa03060

Protein export

4.42E-02

P37108, Q15005

SRP14, SPCS2

Amsacrine

hsa03320

PPAR signaling pathway

2.42E-03

Q6PCB7, Q9UNU6, Q13133, Q02318

SLC27A1, CYP8B1, NR1H3, CYP27A1

Amsacrine

hsa04010

MAPK signaling pathway

4.15E-02

P04049

RAF1

Amsacrine

hsa04012

ErbB signaling pathway

6.63E-03

P16333, P19174, P01106, P04049

NCK1, PLCG1, MYC, RAF1

Amsacrine

hsa04014

Ras signaling pathway

1.71E-03

P04049, P31751, P42338, P20827, P49767, Q13009, Q7LDG7, P0DP23, P63218, P50151, P19174

RAF1, AKT2, PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, CALM1, GNG5, GNG10, PLCG1

Amsacrine

hsa04015

Rap1 signaling pathway

9.89E-05

P04049, P20827, P49767, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P31751, P0DP23, P08514, P19174

RAF1, EFNA1, VEGFC, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, AKT2, CALM1, ITGA2B, PLCG1

Amsacrine

hsa04020

Calcium signaling pathway

4.83E-02

Q08828, P0DP23, P05141, P51828

ADCY1, CALM1, SLC25A5, ADCY7

Amsacrine

hsa04022

cGMP-PKG signaling pathway

6.51E-05

P04049, P18848, P31751, Q08828, P51828, P05141, P0DP23

RAF1, ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1

Amsacrine

hsa04024

cAMP signaling pathway

5.33E-04

Q08828, P51828, P31751, P0DP23, P04049

ADCY1, ADCY7, AKT2, CALM1, RAF1

Amsacrine

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.61E-04

Q8NHW4, P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P09603, P01375

CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, CSF1, TNF

Amsacrine

hsa04062

Chemokine signaling pathway

4.37E-06

P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q08881, Q7LDG7, Q13009, P22694, P04049, P49841, Q8WYR1

CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ITK, RASGRP2, TIAM1, PRKACB, RAF1, GSK3B, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.901
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.917
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09341	CXCL1	Growth-regulated alpha protein	0.859
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P47992	XCL1	Lymphotactin	-0.797
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.797
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P07948	LYN	Tyrosine-protein kinase Lyn	0.713
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P07948	LYN	Tyrosine-protein kinase Lyn	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.743
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.737
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P43250	GRK6	G protein-coupled receptor kinase 6	0.815
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.847
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.771
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.758
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.794
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Amsacrine

hsa04064

NF-kappa B signaling pathway

1.72E-11

P10415, Q13489, P51617, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7

BCL2, BIRC3, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.807
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	1
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
Q04759	PRKCQ	Protein kinase C theta type	O00463	TRAF5	TNF receptor-associated factor 5	0.81
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P51684	CCR6	C-C chemokine receptor type 6	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.868
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q04759	PRKCQ	Protein kinase C theta type	P01375	TNF	Tumor necrosis factor	-0.725
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q04759	PRKCQ	Protein kinase C theta type	Q04759	PRKCQ	Protein kinase C theta type	1
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q04759	PRKCQ	Protein kinase C theta type	-0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.741
P51684	CCR6	C-C chemokine receptor type 6	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	Q13077	TRAF1	TNF receptor-associated factor 1	0.801
P51684	CCR6	C-C chemokine receptor type 6	Q13077	TRAF1	TNF receptor-associated factor 1	0.768
Q04759	PRKCQ	Protein kinase C theta type	Q16548	BCL2A1	Bcl-2-related protein A1	-0.76
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16548	BCL2A1	Bcl-2-related protein A1	0.889
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P07948	LYN	Tyrosine-protein kinase Lyn	0.713
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.809
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q04759	PRKCQ	Protein kinase C theta type	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.846
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.805
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P51684	CCR6	C-C chemokine receptor type 6	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.712
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q04759	PRKCQ	Protein kinase C theta type	P09341	CXCL1	Growth-regulated alpha protein	-0.885
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09341	CXCL1	Growth-regulated alpha protein	0.859
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753

Amsacrine

hsa04068

FoxO signaling pathway

1.99E-02

P04049

RAF1

Amsacrine

hsa04070

Phosphatidylinositol signaling system

1.22E-03

P0DP23, Q14643, O14986, Q16760, P48426, O14732, P17252

CALM1, ITPR1, PIP5K1B, DGKD, PIP4K2A, IMPA2, PRKCA

Amsacrine

hsa04071

Sphingolipid signaling pathway

2.38E-07

P04049, P17252, Q9H228, P01375, Q13362, Q16537, Q9BX95, Q16539, P04637, P10415, Q9UQC2

RAF1, PRKCA, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, MAPK14, TP53, BCL2, GAB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P51684	CCR6	C-C chemokine receptor type 6	P17252	PRKCA	Protein kinase C alpha type	0.738
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.935
P22748	CA4	Carbonic anhydrase 4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.814
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.935
P02763	ORM1	Alpha-1-acid glycoprotein 1	P01375	TNF	Tumor necrosis factor	0.871
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P19652	ORM2	Alpha-1-acid glycoprotein 2	P01375	TNF	Tumor necrosis factor	0.871
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.838
P22748	CA4	Carbonic anhydrase 4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.758
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.838
P51684	CCR6	C-C chemokine receptor type 6	Q16537	PPP2R5E	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	0.819
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.727
P51684	CCR6	C-C chemokine receptor type 6	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.876
P22748	CA4	Carbonic anhydrase 4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.88
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.727
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P51684	CCR6	C-C chemokine receptor type 6	P04637	TP53	Cellular tumor antigen p53	0.728
P02763	ORM1	Alpha-1-acid glycoprotein 1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.791
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P22748	CA4	Carbonic anhydrase 4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.863
P19652	ORM2	Alpha-1-acid glycoprotein 2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.791
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866

Amsacrine

hsa04072

Phospholipase D signaling pathway

2.43E-04

P04049, P31751, P42338, P43657, P25024, P25025, P19174, O14986, Q15438, Q08828, P51828, Q16760

RAF1, AKT2, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKD

Amsacrine

hsa04080

Neuroactive ligand-receptor interaction

3.70E-02

P08311, P48058, Q15722, Q9H228, P43657, P21730, P35318

CTSG, GRIA4, LTB4R, EDG8, P2RY5, C5AR1, ADM

Amsacrine

hsa04110

Cell cycle

2.53E-07

Q9UBD5, P06493, O60566, Q14683, O75293, P30304, P33981, P42773, P01106

ORC3, CDK1, BUB1B, SMC1A, GADD45B, CDC25A, TTK, CDKN2C, MYC

Amsacrine

hsa04114

Oocyte meiosis

1.79E-05

Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738

MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D

Amsacrine

hsa04120

Ubiquitin mediated proteolysis

1.08E-03

Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669

SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12

Amsacrine

hsa04122

Sulfur relay system

3.18E-02

Q16762

TST

Amsacrine

hsa04136

Autophagy - other

5.92E-03

O94817, Q9H1Y0

ATG12, ATG5

Amsacrine

hsa04137

Mitophagy - animal

3.55E-04

Q96CV9, Q9H1Y0, P18848, O43524

OPTN, ATG5, ATF4, FOXO3

Amsacrine

hsa04140

Autophagy - animal

2.41E-03

Q9Y4H2, P31751, P04049, Q7L523, Q9NQL2, O75460, P22694, Q14643, Q9H1Y0, Q04759, Q96GC9, Q8TEV9

IRS2, AKT2, RAF1, RRAGA, RRAGD, ERN1, PRKACB, ITPR1, ATG5, PRKCQ, TMEM49, SMCR8

Amsacrine

hsa04141

Protein processing in endoplasmic reticulum

3.42E-04

P18848, Q15437, O60337, Q99941, P11142, P07900, Q9NR31

ATF4, SEC23B, MARH6, CREBL1, HSPA8, HSP90AA1, SAR1A

Amsacrine

hsa04142

Lysosome

1.46E-02

P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916

HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2

Amsacrine

hsa04144

Endocytosis

1.67E-02

P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4

HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12

Amsacrine

hsa04146

Peroxisome

3.03E-04

O43933, O96011, P56589, Q9UKG9, O75521, P33121

PEX1, PEX11B, PEX3, CROT, ECI2, ACSL1

Amsacrine

hsa04150

mTOR signaling pathway

2.32E-02

P04049

RAF1

Amsacrine

hsa04151

PI3K-Akt signaling pathway

1.19E-03

P62753, P42338, P43657, P27348, P20827, P49767, P07900, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P22105, P14784, Q99941, P18848, O00141, P30281

RPS6, PIK3CB, P2RY5, YWHAQ, EFNA1, VEGFC, HSP90AA1, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, TNXB, IL2RB, CREBL1, ATF4, SGK, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P62753	RPS6	40S ribosomal protein S6	0.722
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P27348	YWHAQ	14-3-3 protein theta	0.833
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P22105	TNXB	Tenascin-X	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.777
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.783
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	O00141	SGK	Serine/threonine-protein kinase Sgk1	0.709
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Amsacrine

hsa04210

Apoptosis

3.64E-03

O76075, P01375, Q9NR28, Q16548, P04049

DFFB, TNF, DIABLO, BCL2A1, RAF1

Amsacrine

hsa04211

Longevity regulating pathway

7.06E-05

Q12778, P31751, Q08828, P51828, Q99941, P18848, Q9UEF7, Q96KQ7

FOXO1, AKT2, ADCY1, ADCY7, CREBL1, ATF4, KL, EHMT2

Amsacrine

hsa04213

Longevity regulating pathway - multiple species

3.34E-04

P31751, P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547

AKT2, PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1

Amsacrine

hsa04217

Necroptosis

2.08E-09

P01375, P01568, P48023, Q13489, P98170, Q9NQC7, Q13546, Q14765, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q99878, Q13557, Q9H444, P21796

TNF, IFNA21, FASLG, BIRC3, BIRC4, CYLD, RIPK1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC14, CAMK2D, CHMP4B, VDAC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.715
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P98170	BIRC4	E3 ubiquitin-protein ligase XIAP	0.716
O00141	SGK	Serine/threonine-protein kinase Sgk1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
O00141	SGK	Serine/threonine-protein kinase Sgk1	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.709
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.724
P02768	ALB	Albumin	P15104	GLUL	Glutamine synthetase	0.717
O00141	SGK	Serine/threonine-protein kinase Sgk1	P15104	GLUL	Glutamine synthetase	0.761
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P15104	GLUL	Glutamine synthetase	0.745
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
O00141	SGK	Serine/threonine-protein kinase Sgk1	P01584	IL1B	Interleukin-1 beta	0.786
P02768	ALB	Albumin	P0C0S5	H2AFZ	Histone H2A.Z	0.756
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75
O00141	SGK	Serine/threonine-protein kinase Sgk1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.717
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	-0.844

Amsacrine

hsa04218

Cellular senescence

3.00E-04

P01106, P31751, P04049, O75293, P30304, P06493, P0DP23

MYC, AKT2, RAF1, GADD45B, CDC25A, CDK1, CALM1

Amsacrine

hsa04261

Adrenergic signaling in cardiomyocytes

6.35E-07

Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, Q16537, P0DP23, Q13557, P17252, P10415, P20020

ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, PPP2R5E, CALM1, CAMK2D, PRKCA, BCL2, ATP2B1

Amsacrine

hsa04270

Vascular smooth muscle contraction

2.48E-04

P0DP23, P04049, Q08828, P51828, P35579, P35749, P35318

CALM1, RAF1, ADCY1, ADCY7, MYH9, MYH11, ADM

Amsacrine

hsa04340

Hedgehog signaling pathway

3.32E-02

P49841, P22694

GSK3B, PRKACB

Amsacrine

hsa04360

Axon guidance

1.51E-02

P16333, P20827, O95631, P42338, P07332, P04049, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, RAF1, PLCG1

Amsacrine

hsa04370

VEGF signaling pathway

1.94E-06

P16298, P31751, Q05397, Q02750, P04049

PPP3CB, AKT2, PTK2, MAP2K1, RAF1

Amsacrine

hsa04371

Apelin signaling pathway

9.63E-08

P62873, P63218, P50151, Q8WYR1, P31751, P04049, Q08828, P51828, Q14814, Q14344, Q13485, P84022, Q16566, P0DP23

GNB1, GNG5, GNG10, PIK3R5, AKT2, RAF1, ADCY1, ADCY7, MEF2D, GNA13, SMAD4, SMAD3, CAMK4, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.899
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.847
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.708
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761

Amsacrine

hsa04380

Osteoclast differentiation

3.07E-07

Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324

CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753
P31751	AKT2	RAC-beta serine/threonine-protein kinase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.885
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P49841	GSK3B	Glycogen synthase kinase-3 beta	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.83
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832

Amsacrine

hsa04510

Focal adhesion

3.48E-02

P04049

RAF1

Amsacrine

hsa04512

ECM-receptor interaction

3.73E-02

P07359, P08514

GP1BA, ITGA2B

Amsacrine

hsa04514

Cell adhesion molecules

8.19E-03

P16109, P56750, O00501

SELP, CLDN17, CLDN5

Amsacrine

hsa04530

Tight junction

1.38E-04

Q8TEU7, P16989, P56750, O00501, Q14247

RAPGEF6, CSDA, CLDN17, CLDN5, CTTN

Amsacrine

hsa04540

Gap junction

1.33E-02

P04049

RAF1

Amsacrine

hsa04550

Signaling pathways regulating pluripotency of stem cells

9.61E-03

Q13873, P04049, Q02750, Q86SE9

BMPR2, RAF1, MAP2K1, PCGF5

Amsacrine

hsa04610

Complement and coagulation cascades

1.94E-07

P25116, P09871, P00734, P0C0L4

F2R, C1S, F2, C4A

Amsacrine

hsa04611

Platelet activation

5.18E-05

P25116, P08514, Q15746, Q8WYR1, P07359

F2R, ITGA2B, MYLK, PIK3R5, GP1BA

Amsacrine

hsa04612

Antigen processing and presentation

2.94E-02

P13765, P26715, P26717, Q13241, P01732, P01375

HLA-DOB, KLRC1, KLRC2, KLRD1, CD8A, TNF

Amsacrine

hsa04613

Neutrophil extracellular trap formation

1.22E-10

P17252, P04049, P16109, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q6FI13, P33778, O60814, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359, O43315, Q16539

PRKCA, RAF1, SELP, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, H2AC18; H2AC19, H2BC3, H2BC12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51684	CCR6	C-C chemokine receptor type 6	P17252	PRKCA	Protein kinase C alpha type	0.738
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
P02763	ORM1	Alpha-1-acid glycoprotein 1	O60603	TLR2	Toll-like receptor 2	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
P22748	CA4	Carbonic anhydrase 4	O60603	TLR2	Toll-like receptor 2	0.919
P19652	ORM2	Alpha-1-acid glycoprotein 2	O60603	TLR2	Toll-like receptor 2	0.783
P02763	ORM1	Alpha-1-acid glycoprotein 1	P05164	MPO	Myeloperoxidase	0.897
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P19652	ORM2	Alpha-1-acid glycoprotein 2	P05164	MPO	Myeloperoxidase	0.897
P02763	ORM1	Alpha-1-acid glycoprotein 1	P08246	ELA2	Neutrophil elastase	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P51684	CCR6	C-C chemokine receptor type 6	P08246	ELA2	Neutrophil elastase	-0.706
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
P19652	ORM2	Alpha-1-acid glycoprotein 2	P08246	ELA2	Neutrophil elastase	0.934
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.897
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P22748	CA4	Carbonic anhydrase 4	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.856
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.897
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P51684	CCR6	C-C chemokine receptor type 6	Q92769	HDAC2	Histone deacetylase 2	0.702
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.755
P51684	CCR6	C-C chemokine receptor type 6	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.86
P22748	CA4	Carbonic anhydrase 4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.866
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.755
P51684	CCR6	C-C chemokine receptor type 6	P33778	H2BC3	Histone H2B type 1-B	0.704
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P51684	CCR6	C-C chemokine receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	-0.713
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P51684	CCR6	C-C chemokine receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	-0.803
P22748	CA4	Carbonic anhydrase 4	Q15080	NCF4	Neutrophil cytosol factor 4	0.951
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q15080	NCF4	Neutrophil cytosol factor 4	0.839
P02763	ORM1	Alpha-1-acid glycoprotein 1	P20160	AZU1	Azurocidin	0.863
P22748	CA4	Carbonic anhydrase 4	P20160	AZU1	Azurocidin	0.747
P19652	ORM2	Alpha-1-acid glycoprotein 2	P20160	AZU1	Azurocidin	0.863
P02763	ORM1	Alpha-1-acid glycoprotein 1	P08311	CTSG	Cathepsin G	0.826
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P22748	CA4	Carbonic anhydrase 4	P08311	CTSG	Cathepsin G	0.717
P19652	ORM2	Alpha-1-acid glycoprotein 2	P08311	CTSG	Cathepsin G	0.826
P02763	ORM1	Alpha-1-acid glycoprotein 1	P49913	CAMP	Cathelicidin antimicrobial peptide	0.832
P19652	ORM2	Alpha-1-acid glycoprotein 2	P49913	CAMP	Cathelicidin antimicrobial peptide	0.832
P02763	ORM1	Alpha-1-acid glycoprotein 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.753
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P22748	CA4	Carbonic anhydrase 4	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
P19652	ORM2	Alpha-1-acid glycoprotein 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.753
P02763	ORM1	Alpha-1-acid glycoprotein 1	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P22748	CA4	Carbonic anhydrase 4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.826
P19652	ORM2	Alpha-1-acid glycoprotein 2	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.751
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P02763	ORM1	Alpha-1-acid glycoprotein 1	P21462	FPR1	fMet-Leu-Phe receptor	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P51684	CCR6	C-C chemokine receptor type 6	P21462	FPR1	fMet-Leu-Phe receptor	-0.7
P22748	CA4	Carbonic anhydrase 4	P21462	FPR1	fMet-Leu-Phe receptor	0.895
P19652	ORM2	Alpha-1-acid glycoprotein 2	P21462	FPR1	fMet-Leu-Phe receptor	0.815
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P22748	CA4	Carbonic anhydrase 4	O43315	AQP9	Aquaporin-9	0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767

Amsacrine

hsa04614

Renin-angiotensin system

2.74E-02

P15144, P08311, O75787

ANPEP, CTSG, ATP6AP2

Amsacrine

hsa04620

Toll-like receptor signaling pathway

6.42E-05

Q13546, P01568, P01584, P31751, Q8NHW4

RIPK1, IFNA21, IL1B, AKT2, CCL4L2

Amsacrine

hsa04621

NOD-like receptor signaling pathway

4.16E-07

P01584, P07900, Q16539, Q14643, P01568, P21796, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q13546, P29728, Q05823, P01375, P09341, P49913, P12838

IL1B, HSP90AA1, MAPK14, ITPR1, IFNA21, VDAC1, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RIPK1, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O00141	SGK	Serine/threonine-protein kinase Sgk1	P01584	IL1B	Interleukin-1 beta	0.786
O00141	SGK	Serine/threonine-protein kinase Sgk1	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.709
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.849
Q04759	PRKCQ	Protein kinase C theta type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.756
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.763
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	-0.705
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q04759	PRKCQ	Protein kinase C theta type	P10599	TXN	Thioredoxin	-0.729
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P10599	TXN	Thioredoxin	0.847
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q9H1Y0	ATG5	Autophagy protein 5	-0.75
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q9H1Y0	ATG5	Autophagy protein 5	-0.726
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q9H1Y0	ATG5	Autophagy protein 5	-0.75
P02763	ORM1	Alpha-1-acid glycoprotein 1	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.739
O00141	SGK	Serine/threonine-protein kinase Sgk1	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.742
Q04759	PRKCQ	Protein kinase C theta type	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	-0.767
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.964
P19652	ORM2	Alpha-1-acid glycoprotein 2	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.739
P02763	ORM1	Alpha-1-acid glycoprotein 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.796
Q04759	PRKCQ	Protein kinase C theta type	O00463	TRAF5	TNF receptor-associated factor 5	0.81
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P19652	ORM2	Alpha-1-acid glycoprotein 2	O00463	TRAF5	TNF receptor-associated factor 5	-0.796
P02763	ORM1	Alpha-1-acid glycoprotein 1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.791
P19652	ORM2	Alpha-1-acid glycoprotein 2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.791
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
Q04759	PRKCQ	Protein kinase C theta type	P29728	OAS2	2'-5'-oligoadenylate synthase 2	0.875
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.72
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q05823	RNASEL	2-5A-dependent ribonuclease	0.771
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q05823	RNASEL	2-5A-dependent ribonuclease	0.771
P02763	ORM1	Alpha-1-acid glycoprotein 1	P01375	TNF	Tumor necrosis factor	0.871
Q04759	PRKCQ	Protein kinase C theta type	P01375	TNF	Tumor necrosis factor	-0.725
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
P19652	ORM2	Alpha-1-acid glycoprotein 2	P01375	TNF	Tumor necrosis factor	0.871
Q04759	PRKCQ	Protein kinase C theta type	P09341	CXCL1	Growth-regulated alpha protein	-0.885
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09341	CXCL1	Growth-regulated alpha protein	0.859
P02763	ORM1	Alpha-1-acid glycoprotein 1	P49913	CAMP	Cathelicidin antimicrobial peptide	0.832
P19652	ORM2	Alpha-1-acid glycoprotein 2	P49913	CAMP	Cathelicidin antimicrobial peptide	0.832
P02763	ORM1	Alpha-1-acid glycoprotein 1	P12838	DEFA4	Neutrophil defensin 4	0.815
Q04759	PRKCQ	Protein kinase C theta type	P12838	DEFA4	Neutrophil defensin 4	-0.833
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P12838	DEFA4	Neutrophil defensin 4	0.842
P19652	ORM2	Alpha-1-acid glycoprotein 2	P12838	DEFA4	Neutrophil defensin 4	0.815

Amsacrine

hsa04622

RIG-I-like receptor signaling pathway

1.02E-03

P01568, Q9NQC7, Q13546

IFNA21, CYLD, RIPK1

Amsacrine

hsa04623

Cytosolic DNA-sensing pathway

4.19E-08

P01584, P01568, Q13546, Q9Y535, Q8NHW4

IL1B, IFNA21, RIPK1, POLR3H, CCL4L2

Amsacrine

hsa04625

C-type lectin receptor signaling pathway

1.30E-07

Q9ULY5, P04049, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539

CLEC4E, RAF1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753
P31751	AKT2	RAC-beta serine/threonine-protein kinase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P49841	GSK3B	Glycogen synthase kinase-3 beta	P20749	BCL3	B-cell lymphoma 3 protein	0.745
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78

Amsacrine

hsa04630

JAK-STAT signaling pathway

8.73E-03

P31751, P23458, Q13651, P04049

AKT2, JAK1, IL10RA, RAF1

Amsacrine

hsa04640

Hematopoietic cell lineage

2.18E-09

P13612, P21926, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P09603, P01584

ITGA4, CD9, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, CSF1, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P13612	ITGA4	Integrin alpha-4	-0.88
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P52732	KIF11	Kinesin-like protein KIF11	P21926	CD9	CD9 antigen	-0.787
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q04759	PRKCQ	Protein kinase C theta type	P27930	IL1R2	Interleukin-1 receptor type 2	-0.733
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P27930	IL1R2	Interleukin-1 receptor type 2	0.906
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P15144	ANPEP	Aminopeptidase N	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P11836	MS4A1	B-lymphocyte antigen CD20	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q04759	PRKCQ	Protein kinase C theta type	P25063	CD24	Signal transducer CD24	-0.903
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P25063	CD24	Signal transducer CD24	0.717
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q04759	PRKCQ	Protein kinase C theta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.713
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.782
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q04759	PRKCQ	Protein kinase C theta type	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.756
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
Q04759	PRKCQ	Protein kinase C theta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.861
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P06493	CDK1	Cyclin-dependent kinase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.732
P06493	CDK1	Cyclin-dependent kinase 1	P06127	CD5	T-cell surface glycoprotein CD5	-0.739
P52732	KIF11	Kinesin-like protein KIF11	P09564	CD7	T-cell antigen CD7	-0.886
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P06493	CDK1	Cyclin-dependent kinase 1	P09564	CD7	T-cell antigen CD7	-0.735
Q04759	PRKCQ	Protein kinase C theta type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.82
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
Q04759	PRKCQ	Protein kinase C theta type	P01375	TNF	Tumor necrosis factor	-0.725
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09603	CSF1	Macrophage colony-stimulating factor 1	0.713
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Amsacrine

hsa04650

Natural killer cell mediated cytotoxicity

4.87E-12

P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, P04049, Q13241, P26718, O14931, O75015, P26717, P26715

PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q04759	PRKCQ	Protein kinase C theta type	P01375	TNF	Tumor necrosis factor	-0.725
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P78314	SH3BP2	SH3 domain-binding protein 2	0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P78314	SH3BP2	SH3 domain-binding protein 2	0.718
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.809
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P06239	LCK	Tyrosine-protein kinase Lck	-0.709
Q04759	PRKCQ	Protein kinase C theta type	O60880	SH2D1A	SH2 domain-containing protein 1A	0.855
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.848
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.764
Q04759	PRKCQ	Protein kinase C theta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.92
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q04759	PRKCQ	Protein kinase C theta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.849
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.846
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
Q04759	PRKCQ	Protein kinase C theta type	P26718	KLRK1	NKG2-D type II integral membrane protein	0.918
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.931
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.803
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.855
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
Q04759	PRKCQ	Protein kinase C theta type	P26717	KLRC2	NKG2-C type II integral membrane protein	0.803
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
Q04759	PRKCQ	Protein kinase C theta type	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.803
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71

Amsacrine

hsa04657

IL-17 signaling pathway

3.39E-08

P07900, O00463, Q16539, P49841, P09341, P14780, Q9UJX4, P80188, P01375, P01584

HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, LCN2, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
O00141	SGK	Serine/threonine-protein kinase Sgk1	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.709
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
P22748	CA4	Carbonic anhydrase 4	O00463	TRAF5	TNF receptor-associated factor 5	-0.826
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P22748	CA4	Carbonic anhydrase 4	Q9UJX4	ANAPC5	Anaphase-promoting complex subunit 5	-0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P22748	CA4	Carbonic anhydrase 4	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
O00141	SGK	Serine/threonine-protein kinase Sgk1	P01584	IL1B	Interleukin-1 beta	0.786
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Amsacrine

hsa04658

Th1 and Th2 cell differentiation

1.65E-16

Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q04759	PRKCQ	Protein kinase C theta type	Q04759	PRKCQ	Protein kinase C theta type	1
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q04759	PRKCQ	Protein kinase C theta type	-0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q04759	PRKCQ	Protein kinase C theta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.713
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.782
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q04759	PRKCQ	Protein kinase C theta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.92
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703
Q04759	PRKCQ	Protein kinase C theta type	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.756
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.734
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.849
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.901
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.809
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P06239	LCK	Tyrosine-protein kinase Lck	-0.709
Q04759	PRKCQ	Protein kinase C theta type	Q14765	STAT4	Signal transducer and activator of transcription 4	0.746
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
Q04759	PRKCQ	Protein kinase C theta type	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.867
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.765
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
Q04759	PRKCQ	Protein kinase C theta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.843
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.927
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q9UL17	TBX21	T-box transcription factor TBX21	-0.73
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q04759	PRKCQ	Protein kinase C theta type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.82
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.731
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q13761	RUNX3	Runt-related transcription factor 3	-0.769
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884

Amsacrine

hsa04659

Th17 cell differentiation

1.45E-14

Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458

PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q04759	PRKCQ	Protein kinase C theta type	Q04759	PRKCQ	Protein kinase C theta type	1
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q04759	PRKCQ	Protein kinase C theta type	-0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.849
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.901
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.809
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P06239	LCK	Tyrosine-protein kinase Lck	-0.709
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
Q04759	PRKCQ	Protein kinase C theta type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.82
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.731
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P14778	IL1R1	Interleukin-1 receptor type 1	0.909
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
Q04759	PRKCQ	Protein kinase C theta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.8
Q04759	PRKCQ	Protein kinase C theta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.843
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.927
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q9UL17	TBX21	T-box transcription factor TBX21	-0.73
Q04759	PRKCQ	Protein kinase C theta type	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.867
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.765
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
Q04759	PRKCQ	Protein kinase C theta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.713
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.782
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
Q04759	PRKCQ	Protein kinase C theta type	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.756
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.734
Q04759	PRKCQ	Protein kinase C theta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.92
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757

Amsacrine

hsa04660

T cell receptor signaling pathway

2.30E-13

P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841

TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q04759	PRKCQ	Protein kinase C theta type	P01375	TNF	Tumor necrosis factor	-0.725
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q04759	PRKCQ	Protein kinase C theta type	Q04759	PRKCQ	Protein kinase C theta type	1
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q04759	PRKCQ	Protein kinase C theta type	-0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q04759	PRKCQ	Protein kinase C theta type	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.733
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.824
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q04759	PRKCQ	Protein kinase C theta type	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.803
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.847
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q04759	PRKCQ	Protein kinase C theta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.713
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.782
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q04759	PRKCQ	Protein kinase C theta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.92
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q04759	PRKCQ	Protein kinase C theta type	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.756
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q04759	PRKCQ	Protein kinase C theta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.861
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q04759	PRKCQ	Protein kinase C theta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.767
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.858
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.809
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.849
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815

Amsacrine

hsa04662

B cell receptor signaling pathway

2.04E-06

P31751, P42338, P60033, P07948, P21854, Q8N149, P04049

AKT2, PIK3CB, CD81, LYN, CD72, LILRA2, RAF1

Amsacrine

hsa04664

Fc epsilon RI signaling pathway

5.80E-07

P01375, P31751, Q16539, P42338, Q9UQC2, P07948, P19174, P04049, P09917, P20292

TNF, AKT2, MAPK14, PIK3CB, GAB2, LYN, PLCG1, RAF1, ALOX5, ALOX5AP

Amsacrine

hsa04666

Fc gamma R-mediated phagocytosis

1.53E-02

P04049, P49006, P06396, P14598, P17252

RAF1, MARCKSL1, GSN, NCF1, PRKCA

Amsacrine

hsa04668

TNF signaling pathway

2.21E-02

P01375, O00463, Q16539, P20749, P14780

TNF, TRAF5, MAPK14, BCL3, MMP9

Amsacrine

hsa04710

Circadian rhythm

4.40E-02

O15516

CLOCK

Amsacrine

hsa04713

Circadian entrainment

2.39E-04

O15399, P0DP23, P62873, P63218, P50151, Q08828, P51828

GRIN2D, CALM1, GNB1, GNG5, GNG10, ADCY1, ADCY7

Amsacrine

hsa04714

Thermogenesis

3.31E-02

P51828, P62753, P12074, O15239

ADCY7, RPS6, COX6A1, NDUFA1

Amsacrine

hsa04720

Long-term potentiation

1.35E-05

P17252, Q16566, P16298, P0DP23, P51812, P18848, O15399, Q08828, Q02750, P04049, Q14643

PRKCA, CAMK4, PPP3CB, CALM1, RPS6KA3, ATF4, GRIN2D, ADCY1, MAP2K1, RAF1, ITPR1

Amsacrine

hsa04722

Neurotrophin signaling pathway

1.76E-06

Q05655, P31751, P04049, P49841, O43524, P48023, P52566, P51617, P10415, P0DP23

PRKCD, AKT2, RAF1, GSK3B, FOXO3, FASLG, ARHGDIB, IRAK1, BCL2, CALM1

Amsacrine

hsa04723

Retrograde endocannabinoid signaling

4.40E-02

Q14643, P63218, P50151, P22694, Q16539

ITPR1, GNG5, GNG10, PRKACB, MAPK14

Amsacrine

hsa04724

Glutamatergic synapse

1.82E-05

O15399, P62873, P63218, P50151, P15104

GRIN2D, GNB1, GNG5, GNG10, GLUL

Amsacrine

hsa04725

Cholinergic synapse

2.93E-06

Q08828, P51828, P62873, P63218, P50151, P18848, Q16566, Q13557, P42338, P31751

ADCY1, ADCY7, GNB1, GNG5, GNG10, ATF4, CAMK4, CAMK2D, PIK3CB, AKT2

Amsacrine

hsa04726

Serotonergic synapse

3.11E-03

P62873, P63218, P50151, P09917, P04049

GNB1, GNG5, GNG10, ALOX5, RAF1

Amsacrine

hsa04727

GABAergic synapse

1.00E-04

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Amsacrine

hsa04728

Dopaminergic synapse

5.85E-05

P31751, Q99941, P18848, Q13557, Q13362, Q14738, P0DP23

AKT2, CREBL1, ATF4, CAMK2D, PPP2R5C, PPP2R5D, CALM1

Amsacrine

hsa04730

Long-term depression

1.16E-02

P04049

RAF1

Amsacrine

hsa04740

Olfactory transduction

1.70E-03

P62873, P0DP23

GNB1, CALM1

Amsacrine

hsa04744

Phototransduction

4.70E-06

P62873, P0DP23

GNB1, CALM1

Amsacrine

hsa04750

Inflammatory mediator regulation of TRP channels

9.84E-08

P14778, P01584, Q08828, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23

IL1R1, IL1B, ADCY1, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.758
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.849
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.763
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P24723	PRKCH	Protein kinase C eta type	-0.705
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q04759	PRKCQ	Protein kinase C theta type	-0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857

Amsacrine

hsa04810

Regulation of actin cytoskeleton

7.86E-03

Q15746, P04049, P08514, P25116

MYLK, RAF1, ITGA2B, F2R

Amsacrine

hsa04910

Insulin signaling pathway

2.43E-05

P0DP23, P22694, P06737, P04049, P31751, P49841

CALM1, PRKACB, PYGL, RAF1, AKT2, GSK3B

Amsacrine

hsa04911

Insulin secretion

4.09E-05

Q08828, P51828, Q99941, P18848, Q13557

ADCY1, ADCY7, CREBL1, ATF4, CAMK2D

Amsacrine

hsa04912

GnRH signaling pathway

2.72E-05

P17252, Q08828, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP24, P0DP23, P22694, P04049

PRKCA, ADCY1, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM2, CALM1, PRKACB, RAF1

Amsacrine

hsa04914

Progesterone-mediated oocyte maturation

2.23E-04

Q17RY0, Q9Y6D9, P51812, Q02750, P04049

CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1

Amsacrine

hsa04915

Estrogen signaling pathway

1.01E-06

P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, Q15788

RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, NCOA1

Amsacrine

hsa04916

Melanogenesis

7.31E-04

P0DP23, Q08828, P51828, P04049

CALM1, ADCY1, ADCY7, RAF1

Amsacrine

hsa04917

Prolactin signaling pathway

3.49E-04

P31751, P04049

AKT2, RAF1

Amsacrine

hsa04918

Thyroid hormone synthesis

1.69E-03

P51828, Q99941, P18848, P02768

ADCY7, CREBL1, ATF4, ALB

Amsacrine

hsa04919

Thyroid hormone signaling pathway

6.83E-04

P49841, P04049, P22694, O60244, Q9NVC6

GSK3B, RAF1, PRKACB, MED14, MED17

Amsacrine

hsa04920

Adipocytokine signaling pathway

4.19E-02

P31751

AKT2

Amsacrine

hsa04921

Oxytocin signaling pathway

2.32E-02

P04049

RAF1

Amsacrine

hsa04922

Glucagon signaling pathway

1.79E-03

P31751, P0DP23

AKT2, CALM1

Amsacrine

hsa04923

Regulation of lipolysis in adipocytes

5.39E-05

Q08828, P51828, P07550, P42338, Q9Y4H2, P31751

ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2

Amsacrine

hsa04924

Renin secretion

3.01E-02

P0DP23

CALM1

Amsacrine

hsa04925

Aldosterone synthesis and secretion

3.89E-06

Q14643, Q99941, P18848, Q08828, P51828, P0DP23, P17252, Q13557, P20020

ITPR1, CREBL1, ATF4, ADCY1, ADCY7, CALM1, PRKCA, CAMK2D, ATP2B1

Amsacrine

hsa04926

Relaxin signaling pathway

1.22E-05

P31751, P42338, P63218, P50151, Q99941, P18848, P49767, Q08828, P51828, P04049, P49407

AKT2, PIK3CB, GNG5, GNG10, CREBL1, ATF4, VEGFC, ADCY1, ADCY7, RAF1, ARRB1

Amsacrine

hsa04927

Cortisol synthesis and secretion

1.76E-04

Q99941, P18848, Q08828, P51828

CREBL1, ATF4, ADCY1, ADCY7

Amsacrine

hsa04928

Parathyroid hormone synthesis, secretion and action

3.95E-03

P51828, P04049, Q99941, P18848

ADCY7, RAF1, CREBL1, ATF4

Amsacrine

hsa04929

GnRH secretion

2.28E-04

P42338, P31751, P49407, P04049

PIK3CB, AKT2, ARRB1, RAF1

Amsacrine

hsa04930

Type II diabetes mellitus

2.68E-02

Q05655

PRKCD

Amsacrine

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Amsacrine

hsa04932

Non-alcoholic fatty liver disease

1.18E-07

P31751, P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, O95298

AKT2, TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
O00141	SGK	Serine/threonine-protein kinase Sgk1	P01584	IL1B	Interleukin-1 beta	0.786
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
O00141	SGK	Serine/threonine-protein kinase Sgk1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.742
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
O00141	SGK	Serine/threonine-protein kinase Sgk1	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.766
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778

Amsacrine

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.21E-02

P84022, Q13485, P42338, P49767, P19174

SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1

Amsacrine

hsa04934

Cushing syndrome

2.20E-04

Q99941, P18848, Q08828, P51828, Q13557

CREBL1, ATF4, ADCY1, ADCY7, CAMK2D

Amsacrine

hsa04935

Growth hormone synthesis, secretion and action

3.68E-04

Q08828, P51828, P04049, Q99941, P18848, P31751

ADCY1, ADCY7, RAF1, CREBL1, ATF4, AKT2

Amsacrine

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Amsacrine

hsa04960

Aldosterone-regulated sodium reabsorption

4.40E-02

O00141

SGK

Amsacrine

hsa04962

Vasopressin-regulated water reabsorption

7.22E-03

P52566, P62491

ARHGDIB, RAB11A

Amsacrine

hsa04964

Proximal tubule bicarbonate reclamation

2.17E-03

P00918

CA2

Amsacrine

hsa04966

Collecting duct acid secretion

1.43E-04

P02730, P00918, Q9Y666

SLC4A1, CA2, SLC12A7

Amsacrine

hsa04970

Salivary secretion

1.27E-05

Q08828, P51828, Q14643, P20020, P17252, P0DP23

ADCY1, ADCY7, ITPR1, ATP2B1, PRKCA, CALM1

Amsacrine

hsa04971

Gastric acid secretion

4.91E-04

Q08828, P51828, P15311, P0DP23

ADCY1, ADCY7, VIL2, CALM1

Amsacrine

hsa04972

Pancreatic secretion

1.00E-02

Q14643, P20020, P17252

ITPR1, ATP2B1, PRKCA

Amsacrine

hsa04973

Carbohydrate digestion and absorption

4.61E-03

O43451, P42338, P31751

MGAM, PIK3CB, AKT2

Amsacrine

hsa04975

Fat digestion and absorption

1.43E-03

O14494

PLPP1

Amsacrine

hsa04976

Bile secretion

9.87E-05

Q08828, P51828, P22694, P08183, Q14032

ADCY1, ADCY7, PRKACB, ABCB1, BAAT

Amsacrine

hsa05010

Alzheimer disease

1.82E-04

O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070

NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4

Amsacrine

hsa05012

Parkinson disease

2.53E-02

O15239, P13073, P05141, P18848, Q13557

NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2D

Amsacrine

hsa05016

Huntington disease

1.01E-06

O15239, O95298, P13073, P12074, Q9GZM3, P24928, P30876, P62487, P52435, P05141, Q9NYC9, O75460, P28070, O00232

NDUFA1, NDUFC2, COX4I1, COX6A1, POLR2J2, POLR2A, POLR2B, POLR2G, POLR2J, SLC25A5, DNAH9, ERN1, PSMB4, PSMD12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P22001	KCNA3	Potassium voltage-gated channel subfamily A member 3	Q9GZM3	POLR2J2	DNA-directed RNA polymerase II subunit RPB11-b1	0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
Q00535	CDK5	Cyclin-dependent-like kinase 5	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.709
P02768	ALB	Albumin	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
Q00535	CDK5	Cyclin-dependent-like kinase 5	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.703
P02768	ALB	Albumin	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.78
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.758
P22001	KCNA3	Potassium voltage-gated channel subfamily A member 3	P52435	POLR2J	DNA-directed RNA polymerase II subunit RPB11-a	0.76
P22001	KCNA3	Potassium voltage-gated channel subfamily A member 3	Q9GZM3	POLR2J2	DNA-directed RNA polymerase II subunit RPB11-b1	0.76
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
P22001	KCNA3	Potassium voltage-gated channel subfamily A member 3	Q9NYC9	DNAH9	Dynein axonemal heavy chain 9	0.785
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703

Amsacrine

hsa05017

Spinocerebellar ataxia

3.94E-02

O75460, P31751, P28070, P05141

ERN1, AKT2, PSMB4, SLC25A5

Amsacrine

hsa05020

Prion disease

3.37E-03

P13591, P01584, P11142, O15239, P13073, P18848, P05141

NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5

Amsacrine

hsa05022

Pathways of neurodegeneration - multiple diseases

4.19E-04

O15239, O95298, P13073, Q8TEV9, O75460, P18848, P05141, Q00535, P01584, P0DP23, Q13557, P28070

NDUFA1, NDUFC2, COX4I1, SMCR8, ERN1, ATF4, SLC25A5, CDK5, IL1B, CALM1, CAMK2D, PSMB4

Amsacrine

hsa05030

Cocaine addiction

6.96E-03

Q00535, Q99941, P18848

CDK5, CREBL1, ATF4

Amsacrine

hsa05031

Amphetamine addiction

9.24E-04

P0DP23, Q13557, Q99941, P18848

CALM1, CAMK2D, CREBL1, ATF4

Amsacrine

hsa05032

Morphine addiction

1.34E-02

P62873, P63218, P50151, P43250

GNB1, GNG5, GNG10, GRK6

Amsacrine

hsa05034

Alcoholism

4.37E-05

O15399, Q16566, P0DP23, Q96RR4, P62873, P63218, P50151, P04049, Q93079, P84243

GRIN2D, CAMK4, CALM1, CAMKK2, GNB1, GNG5, GNG10, RAF1, H2BC9, H3F3A

Amsacrine

hsa05100

Bacterial invasion of epithelial cells

1.82E-03

Q14141, Q05397, Q92529, Q96JJ3

SEPT6, PTK2, SHC3, ELMO2

Amsacrine

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.26E-06

Q16539, P09341, P19875, P19174, P25024, P25025, P07948

MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN

Amsacrine

hsa05130

Pathogenic Escherichia coli infection

7.39E-03

Q14247, P56750, O00501, P25116

CTTN, CLDN17, CLDN5, F2R

Amsacrine

hsa05131

Shigellosis

1.08E-04

P01375, O00463, P14778, Q16539, Q05655, Q04759, Q9UDY8, P61088, Q9NQL2, Q9H1Y0, P12814, P20810, Q14643, O43524, P49841, P10415, P21796, Q96A32, P07737

TNF, TRAF5, IL1R1, MAPK14, PRKCD, PRKCQ, MALT1, UBE2N, RRAGD, ATG5, ACTN1, CAST, ITPR1, FOXO3, GSK3B, BCL2, VDAC1, MYLPF, PFN1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P02763	ORM1	Alpha-1-acid glycoprotein 1	P01375	TNF	Tumor necrosis factor	0.871
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
P19652	ORM2	Alpha-1-acid glycoprotein 2	P01375	TNF	Tumor necrosis factor	0.871
P02763	ORM1	Alpha-1-acid glycoprotein 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.796
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P19652	ORM2	Alpha-1-acid glycoprotein 2	O00463	TRAF5	TNF receptor-associated factor 5	-0.796
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.823
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.849
Q05655	PRKCD	Protein kinase C delta type	Q05655	PRKCD	Protein kinase C delta type	1
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q04759	PRKCQ	Protein kinase C theta type	-0.802
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q04759	PRKCQ	Protein kinase C theta type	-0.807
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q04759	PRKCQ	Protein kinase C theta type	-0.802
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.766
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.766
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	-0.751
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.725
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q9H1Y0	ATG5	Autophagy protein 5	-0.75
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q9H1Y0	ATG5	Autophagy protein 5	-0.726
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q9H1Y0	ATG5	Autophagy protein 5	-0.75
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P12814	ACTN1	Alpha-actinin-1	0.788
P02763	ORM1	Alpha-1-acid glycoprotein 1	P20810	CAST	Calpastatin	-0.775
P19652	ORM2	Alpha-1-acid glycoprotein 2	P20810	CAST	Calpastatin	-0.775
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.763
P02763	ORM1	Alpha-1-acid glycoprotein 1	O43524	FOXO3	Forkhead box protein O3	0.736
P19652	ORM2	Alpha-1-acid glycoprotein 2	O43524	FOXO3	Forkhead box protein O3	0.736
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.794
P02763	ORM1	Alpha-1-acid glycoprotein 1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.791
P19652	ORM2	Alpha-1-acid glycoprotein 2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.791
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	-0.705
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q96A32	MYLPF	Myosin regulatory light chain 2, skeletal muscle isoform	0.726
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q96A32	MYLPF	Myosin regulatory light chain 2, skeletal muscle isoform	0.726
Q05655	PRKCD	Protein kinase C delta type	P07737	PFN1	Profilin-1	0.77

Amsacrine

hsa05132

Salmonella infection

1.41E-07

P51617, P04049, Q9UJU2, P84095, Q13546, Q13489, P10415, O75369, P07737, O60603, Q9BQS8, P51808, Q13561, O60282, Q13509, P68371

IRAK1, RAF1, LEF1, RHOG, RIPK1, BIRC3, BCL2, FLNB, PFN1, TLR2, FYCO1, DYNLT3, DCTN2, KIF5C, TUBB3, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	1
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.768
P51684	CCR6	C-C chemokine receptor type 6	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.835
Q05655	PRKCD	Protein kinase C delta type	P84095	RHOG	Rho-related GTP-binding protein RhoG	0.71
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P51684	CCR6	C-C chemokine receptor type 6	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.807
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	O75369	FLNB	Filamin-B	-0.713
P51684	CCR6	C-C chemokine receptor type 6	O75369	FLNB	Filamin-B	-0.717
Q05655	PRKCD	Protein kinase C delta type	P07737	PFN1	Profilin-1	0.77
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.812
P51684	CCR6	C-C chemokine receptor type 6	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.721
P51684	CCR6	C-C chemokine receptor type 6	P51808	DYNLT3	Dynein light chain Tctex-type 3	0.731
P51684	CCR6	C-C chemokine receptor type 6	Q13561	DCTN2	Dynactin subunit 2	-0.781
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	Q13509	TUBB3	Tubulin beta-3 chain	-0.757
P51684	CCR6	C-C chemokine receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	-0.835
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747

Amsacrine

hsa05133

Pertussis

1.31E-05

P0DP23, P09871, P0C0L4, Q02556

CALM1, C1S, C4A, IRF8

Amsacrine

hsa05134

Legionellosis

4.93E-05

P01584, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875

IL1B, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2

Amsacrine

hsa05135

Yersinia infection

2.34E-03

Q05397, P51812, P13612, P06239, Q16539, Q02750, P49841, Q96JJ3, P01730, P01732

PTK2, RPS6KA3, ITGA4, LCK, MAPK14, MAP2K1, GSK3B, ELMO2, CD4, CD8A

Amsacrine

hsa05140

Leishmaniasis

1.10E-04

P13612, O75015, P14598, P23458, P13765, O60603, P01375, P01584, P49006, Q16539, P51617, Q15080

ITGA4, FCGR3B, NCF1, JAK1, HLA-DOB, TLR2, TNF, IL1B, MARCKSL1, MAPK14, IRAK1, NCF4

Amsacrine

hsa05143

African trypanosomiasis

1.11E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Amsacrine

hsa05144

Malaria

5.99E-07

P60033, P69905, P68871, O60603, P01375, P35443, P01584, P26718

CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, KLRK1

Amsacrine

hsa05146

Amoebiasis

8.98E-10

P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q04759	PRKCQ	Protein kinase C theta type	P09341	CXCL1	Growth-regulated alpha protein	-0.885
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09341	CXCL1	Growth-regulated alpha protein	0.859
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q04759	PRKCQ	Protein kinase C theta type	P27930	IL1R2	Interleukin-1 receptor type 2	-0.733
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P27930	IL1R2	Interleukin-1 receptor type 2	0.906
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q04759	PRKCQ	Protein kinase C theta type	P01375	TNF	Tumor necrosis factor	-0.725
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q04759	PRKCQ	Protein kinase C theta type	P05089	ARG1	Arginase-1	-0.899
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P05089	ARG1	Arginase-1	0.89
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
Q04759	PRKCQ	Protein kinase C theta type	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.755
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.758
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q04759	PRKCQ	Protein kinase C theta type	P12814	ACTN1	Alpha-actinin-1	-0.821
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P12814	ACTN1	Alpha-actinin-1	0.788
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
Q04759	PRKCQ	Protein kinase C theta type	P08311	CTSG	Cathepsin G	-0.913
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P08311	CTSG	Cathepsin G	0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717

Amsacrine

hsa05150

Staphylococcus aureus infection

6.50E-06

P0C0L4, P21730, P21462, O75015, P13646, Q14532, P59665, P59666, P12838, P49913

C4A, C5AR1, FPR1, FCGR3B, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Amsacrine

hsa05152

Tuberculosis

9.73E-06

P04049, P0DP23, O75015, P48382, O60603, P01375, P31751, P10415, P49913, Q9UDY8, P51617

RAF1, CALM1, FCGR3B, RFX5, TLR2, TNF, AKT2, BCL2, CAMP, MALT1, IRAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P0DP23	CALM1	Calmodulin-1	-0.703
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
P02763	ORM1	Alpha-1-acid glycoprotein 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.753
P19652	ORM2	Alpha-1-acid glycoprotein 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.753
P02763	ORM1	Alpha-1-acid glycoprotein 1	P48382	RFX5	DNA-binding protein RFX5	-0.912
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P48382	RFX5	DNA-binding protein RFX5	0.727
P19652	ORM2	Alpha-1-acid glycoprotein 2	P48382	RFX5	DNA-binding protein RFX5	-0.912
P02763	ORM1	Alpha-1-acid glycoprotein 1	O60603	TLR2	Toll-like receptor 2	0.783
P19652	ORM2	Alpha-1-acid glycoprotein 2	O60603	TLR2	Toll-like receptor 2	0.783
P02763	ORM1	Alpha-1-acid glycoprotein 1	P01375	TNF	Tumor necrosis factor	0.871
P19652	ORM2	Alpha-1-acid glycoprotein 2	P01375	TNF	Tumor necrosis factor	0.871
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
P02763	ORM1	Alpha-1-acid glycoprotein 1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.791
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.807
P19652	ORM2	Alpha-1-acid glycoprotein 2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.791
P02763	ORM1	Alpha-1-acid glycoprotein 1	P49913	CAMP	Cathelicidin antimicrobial peptide	0.832
P19652	ORM2	Alpha-1-acid glycoprotein 2	P49913	CAMP	Cathelicidin antimicrobial peptide	0.832
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.766
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.741
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.766
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	1

Amsacrine

hsa05160

Hepatitis C

1.40E-03

P60033, P04049, P49841, P01375, P48023

CD81, RAF1, GSK3B, TNF, FASLG

Amsacrine

hsa05161

Hepatitis B

5.33E-03

P04049, Q99941, P18848, P27348

RAF1, CREBL1, ATF4, YWHAQ

Amsacrine

hsa05162

Measles

3.74E-03

P23458, P0DMV8, P11142, P01584, Q9NP90

JAK1, HSPA1A, HSPA8, IL1B, RAB9B

Amsacrine

hsa05163

Human cytomegalovirus infection

1.78E-09

P31751, P04049, P01375, P62873, P63218, P50151, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P22694, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P04637, O00463, P30101, P01568

AKT2, RAF1, TNF, GNB1, GNG5, GNG10, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, PRKACB, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5, PDIA3, IFNA21

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.743
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.737
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.763
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.758
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.794
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.702
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P30101	PDIA3	Protein disulfide-isomerase A3	-0.825
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703

Amsacrine

hsa05164

Influenza A

1.49E-02

P31751, P01584, P23458, P05141, P04049, Q9UBU9

AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1

Amsacrine

hsa05166

Human T-cell leukemia virus 1 infection

3.90E-02

P23458, P05141, P62826, Q08828, P51828, P18848, P31751

JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2

Amsacrine

hsa05167

Kaposi sarcoma-associated herpesvirus infection

3.27E-04

P01568, P31751, P62873, P63218, P50151, P04049, P07948, P0DP23

IFNA21, AKT2, GNB1, GNG5, GNG10, RAF1, LYN, CALM1

Amsacrine

hsa05168

Herpes simplex virus 1 infection

6.21E-03

P25963, P01568, Q07955, Q01130, P84103, Q13243, Q13489, P30101, Q9Y2A4, Q13398, P51522, P17038, P52738, O75820, Q9NZL3

NFKBIA, IFNA21, SFRS1, SFRS2, SFRS3, SFRS5, BIRC3, PDIA3, ZNF443, ZNF211, ZNF83, ZNF43, ZNF140, ZNF189, ZNF224

Amsacrine

hsa05169

Epstein-Barr virus infection

5.46E-06

P13765, Q13547, Q92769, P04637, Q13546, O00463, P10415, Q16539, P42338, P07948, Q13761, P24522, O75293, P01375, O60603, P29728, P51617, P07766, P09693, P20963

HLA-DOB, HDAC1, HDAC2, TP53, RIPK1, TRAF5, BCL2, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, TNF, TLR2, OAS2, IRAK1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q04759	PRKCQ	Protein kinase C theta type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.82
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.748
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.731
Q04759	PRKCQ	Protein kinase C theta type	Q13547	HDAC1	Histone deacetylase 1	0.723
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q13547	HDAC1	Histone deacetylase 1	-0.774
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q13547	HDAC1	Histone deacetylase 1	-0.795
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q13547	HDAC1	Histone deacetylase 1	-0.727
P51684	CCR6	C-C chemokine receptor type 6	Q92769	HDAC2	Histone deacetylase 2	0.702
P51684	CCR6	C-C chemokine receptor type 6	P04637	TP53	Cellular tumor antigen p53	0.728
P51684	CCR6	C-C chemokine receptor type 6	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.868
Q04759	PRKCQ	Protein kinase C theta type	O00463	TRAF5	TNF receptor-associated factor 5	0.81
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.849
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.901
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	1
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P07948	LYN	Tyrosine-protein kinase Lyn	0.735
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P07948	LYN	Tyrosine-protein kinase Lyn	0.713
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q13761	RUNX3	Runt-related transcription factor 3	-0.708
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q13761	RUNX3	Runt-related transcription factor 3	-0.769
Q04759	PRKCQ	Protein kinase C theta type	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.846
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.805
P51684	CCR6	C-C chemokine receptor type 6	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.712
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.768
Q04759	PRKCQ	Protein kinase C theta type	P01375	TNF	Tumor necrosis factor	-0.725
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	O60603	TLR2	Toll-like receptor 2	0.72
Q04759	PRKCQ	Protein kinase C theta type	P29728	OAS2	2'-5'-oligoadenylate synthase 2	0.875
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.72
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
Q04759	PRKCQ	Protein kinase C theta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.713
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.77
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.782
Q04759	PRKCQ	Protein kinase C theta type	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.756
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
P51684	CCR6	C-C chemokine receptor type 6	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.753
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.734
Q04759	PRKCQ	Protein kinase C theta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.92
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.862
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703

Amsacrine

hsa05170

Human immunodeficiency virus 1 infection

4.29E-07

P31751, P04049, P62873, P63218, P50151, P0DP23, P17252, Q13546, P30101, Q14643, P01568, P51617, O60603, P23528, P09693, P10415, Q9Y6Q5

AKT2, RAF1, GNB1, GNG5, GNG10, CALM1, PRKCA, RIPK1, PDIA3, ITPR1, IFNA21, IRAK1, TLR2, CFL1, CD3G, BCL2, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.759
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P0DP23	CALM1	Calmodulin-1	-0.703
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
P51684	CCR6	C-C chemokine receptor type 6	P0DP23	CALM1	Calmodulin-1	-0.734
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
P51684	CCR6	C-C chemokine receptor type 6	P17252	PRKCA	Protein kinase C alpha type	0.738
P51684	CCR6	C-C chemokine receptor type 6	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.868
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P30101	PDIA3	Protein disulfide-isomerase A3	-0.825
P51684	CCR6	C-C chemokine receptor type 6	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.81
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	1
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P23528	CFL1	Cofilin-1	0.738
P51684	CCR6	C-C chemokine receptor type 6	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.753
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.807
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.814
P51684	CCR6	C-C chemokine receptor type 6	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.86

Amsacrine

hsa05171

Coronavirus disease - COVID-19

8.23E-07

P01584, P62753, P25398, P62249, P40429, P36578, P32969, P27635, Q07020, P62888, P18077, P61927, P61513, P05386, P62829

IL1B, RPS6, RPS12, RPS16, RPL13A, RPL4, RPL9, RPL10, RPL18, RPL30, RPL35A, RPL37, RPL37A, RPLP1, RPL23

Amsacrine

hsa05200

Pathways in cancer

7.57E-07

Q13751, P42338, P08238, P19174, Q9UJU2, P43246, P84022, Q13485, Q13547, P14923, P30281, P10415, Q13489, P98170, Q13077, P49767, P31751, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, Q9UM47, P78417, O75293, P0DP23, P01568, P14784, P01042

LAMB3, PIK3CB, HSP90AB1, PLCG1, LEF1, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, BCL2, BIRC3, BIRC4, TRAF1, VEGFC, AKT2, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, NOTCH3, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, KNG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13751	LAMB3	Laminin subunit beta-3	0.868
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.724
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.768
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P43246	MSH2	DNA mismatch repair protein Msh2	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.847
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.899
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P14923	JUP	Junction plakoglobin	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.807
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.715
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P98170	BIRC4	E3 ubiquitin-protein ligase XIAP	0.716
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	Q13077	TRAF1	TNF receptor-associated factor 1	0.801
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.759
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	-0.71
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P78417	GSTO1	Glutathione S-transferase omega-1	0.754
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.708
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P0DP23	CALM1	Calmodulin-1	-0.703
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01042	KNG1	Kininogen-1	0.708

Amsacrine

hsa05202

Transcriptional misregulation in cancer

4.95E-05

Q15532, P41732, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522

SS18, TSPAN7, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22748	CA4	Carbonic anhydrase 4	Q15532	SS18	Protein SSXT	-0.862
P22748	CA4	Carbonic anhydrase 4	P41732	TSPAN7	Tetraspanin-7	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
Q04759	PRKCQ	Protein kinase C theta type	P14780	MMP9	Matrix metalloproteinase-9	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
Q04759	PRKCQ	Protein kinase C theta type	P27930	IL1R2	Interleukin-1 receptor type 2	-0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P22748	CA4	Carbonic anhydrase 4	P27930	IL1R2	Interleukin-1 receptor type 2	0.708
P22748	CA4	Carbonic anhydrase 4	P14923	JUP	Junction plakoglobin	-0.772
Q04759	PRKCQ	Protein kinase C theta type	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.745
Q04759	PRKCQ	Protein kinase C theta type	Q16548	BCL2A1	Bcl-2-related protein A1	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P22748	CA4	Carbonic anhydrase 4	Q16548	BCL2A1	Bcl-2-related protein A1	0.833
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P22748	CA4	Carbonic anhydrase 4	Q13077	TRAF1	TNF receptor-associated factor 1	-0.718
P22748	CA4	Carbonic anhydrase 4	O15550	UTX	Lysine-specific demethylase 6A	0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
Q04759	PRKCQ	Protein kinase C theta type	P05164	MPO	Myeloperoxidase	-0.88
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
Q04759	PRKCQ	Protein kinase C theta type	P12838	DEFA4	Neutrophil defensin 4	-0.833
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
Q04759	PRKCQ	Protein kinase C theta type	P08246	ELA2	Neutrophil elastase	-0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
Q04759	PRKCQ	Protein kinase C theta type	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
Q04759	PRKCQ	Protein kinase C theta type	Q13547	HDAC1	Histone deacetylase 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
Q04759	PRKCQ	Protein kinase C theta type	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.846
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P22748	CA4	Carbonic anhydrase 4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.769

Amsacrine

hsa05203

Viral carcinogenesis

1.46E-02

Q99941, P18848, P27348, P61978

CREBL1, ATF4, YWHAQ, HNRPK

Amsacrine

hsa05204

Chemical carcinogenesis

4.00E-02

P09211

GSTP1

Amsacrine

hsa05205

Proteoglycans in cancer

1.03E-02

Q13009, Q12955, O75369, P04049, P08962

TIAM1, ANK3, FLNB, RAF1, CD63

Amsacrine

hsa05206

MicroRNAs in cancer

3.15E-02

P04049

RAF1

Amsacrine

hsa05210

Colorectal cancer

7.91E-03

P84022, Q13485, P43246, P04049, O75293

SMAD3, SMAD4, MSH2, RAF1, GADD45B

Amsacrine

hsa05211

Renal cell carcinoma

1.29E-03

P31751, P04049

AKT2, RAF1

Amsacrine

hsa05212

Pancreatic cancer

1.42E-05

P42338, P31751, P04049, Q15311, P23458, P84022, Q13485, O75293

PIK3CB, AKT2, RAF1, RALBP1, JAK1, SMAD3, SMAD4, GADD45B

Amsacrine

hsa05213

Endometrial cancer

8.16E-04

P31751, P04049

AKT2, RAF1

Amsacrine

hsa05214

Glioma

2.93E-06

P0DP23, Q16566, P17252, P04049, P31751, P04637, P24522, O75293

CALM1, CAMK4, PRKCA, RAF1, AKT2, TP53, GADD45A, GADD45B

Amsacrine

hsa05215

Prostate cancer

1.33E-02

P04049

RAF1

Amsacrine

hsa05216

Thyroid cancer

1.58E-03

P01106, Q9UJU2, P04637, P24522, O75293

MYC, LEF1, TP53, GADD45A, GADD45B

Amsacrine

hsa05217

Basal cell carcinoma

4.48E-03

Q13635, P49841, Q9UJU2, P04637, P24522

PTCH1, GSK3B, LEF1, TP53, GADD45A

Amsacrine

hsa05218

Melanoma

4.47E-04

P31751, P04049

AKT2, RAF1

Amsacrine

hsa05219

Bladder cancer

5.65E-03

P14780, P04637, P04049

MMP9, TP53, RAF1

Amsacrine

hsa05220

Chronic myeloid leukemia

4.90E-04

Q13547, Q13485, P84022, P31751, P42338, P04049, O75293

HDAC1, SMAD4, SMAD3, AKT2, PIK3CB, RAF1, GADD45B

Amsacrine

hsa05221

Acute myeloid leukemia

8.16E-04

P31751, P04049

AKT2, RAF1

Amsacrine

hsa05222

Small cell lung cancer

4.77E-03

P31751, Q13751, Q13489, P98170, O75293

AKT2, LAMB3, BIRC3, BIRC4, GADD45B

Amsacrine

hsa05223

Non-small cell lung cancer

3.89E-05

P31751, P10826, P04049, Q9HC35, O75293

AKT2, RARB, RAF1, EML4, GADD45B

Amsacrine

hsa05224

Breast cancer

1.24E-02

P04049, P49841, Q92837, P04637, P24522

RAF1, GSK3B, FRAT1, TP53, GADD45A

Amsacrine

hsa05225

Hepatocellular carcinoma

1.33E-02

P04049

RAF1

Amsacrine

hsa05226

Gastric cancer

6.81E-04

P04049, P31751

RAF1, AKT2

Amsacrine

hsa05230

Central carbon metabolism in cancer

1.12E-03

P04049, P31751

RAF1, AKT2

Amsacrine

hsa05231

Choline metabolism in cancer

2.66E-05

P04049, P31751, Q9Y259, P19174, P49619, Q16760, O14986

RAF1, AKT2, CHKB, PLCG1, DGKG, DGKD, PIP5K1B

Amsacrine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

6.51E-11

P42338, O95267, P19174, P07766, P20963, P09693, P06239, P04049, P23458, O60603, Q04759, Q16539, Q9HC35, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, JAK1, TLR2, PRKCQ, MAPK14, EML4, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q04759	PRKCQ	Protein kinase C theta type	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.733
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.824
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q04759	PRKCQ	Protein kinase C theta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.713
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.782
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q04759	PRKCQ	Protein kinase C theta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.92
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703
Q04759	PRKCQ	Protein kinase C theta type	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.756
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.734
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.809
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P06239	LCK	Tyrosine-protein kinase Lck	-0.709
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	O60603	TLR2	Toll-like receptor 2	0.72
Q04759	PRKCQ	Protein kinase C theta type	Q04759	PRKCQ	Protein kinase C theta type	1
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q04759	PRKCQ	Protein kinase C theta type	-0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.849
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.901
P52732	KIF11	Kinesin-like protein KIF11	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.794
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719

Amsacrine

hsa05310

Asthma

3.76E-04

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Amsacrine

hsa05321

Inflammatory bowel disease

1.56E-06

O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q04759	PRKCQ	Protein kinase C theta type	P01375	TNF	Tumor necrosis factor	-0.725
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q04759	PRKCQ	Protein kinase C theta type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.82
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
Q04759	PRKCQ	Protein kinase C theta type	Q14765	STAT4	Signal transducer and activator of transcription 4	0.746
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
Q04759	PRKCQ	Protein kinase C theta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.843
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.927
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q04759	PRKCQ	Protein kinase C theta type	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.867
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.765
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q04759	PRKCQ	Protein kinase C theta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.8

Amsacrine

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Amsacrine

hsa05332

Graft-versus-host disease

7.49E-05

P13765, P48023, P01375, P26715, Q13241

HLA-DOB, FASLG, TNF, KLRC1, KLRD1

Amsacrine

hsa05340

Primary immunodeficiency

2.90E-04

P01730, P01732, P11912, P07766, P06239

CD4, CD8A, CD79A, CD3E, LCK

Amsacrine

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

2.17E-03

P54284

CACNB3

Amsacrine

hsa05414

Dilated cardiomyopathy

4.55E-02

P54284, P26678

CACNB3, PLN

Amsacrine

hsa05415

Diabetic cardiomyopathy

2.87E-02

P05141, O15239, P13073, Q13557

SLC25A5, NDUFA1, COX4I1, CAMK2D

Amsacrine

hsa05418

Fluid shear stress and atherosclerosis

1.27E-05

Q16539, P31751, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23

MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1

Community members of Amsacrine (S_DC: 10.08)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

TOP2A

DNA topoisomerase 2Nonealpha

Reported

0.1992

0.4659

0.1927

1.2242

P02763

ORM1

AlphaNone1Noneacid glycoprotein 1

Reported

0.0553

0.0579

0.1435

P02768

ALB

Albumin

Reported

0.2848

0.9111

0.0857

2.0502

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

P33981

TTK

Dual specificity protein kinase TTK

Predicted

0.0039

0.5805

0.259

1.422

P18054

ALOX12

Polyunsaturated fatty acid lipoxygenase ALOX12

Predicted

0.0075

0.3703

0.2416

0.986

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

P06493

CDK1

CyclinNonedependent kinase 1

Predicted

0.013

0.604

2.6105

Q00535

CDK5

CyclinNonedependentNonelike kinase 5

Predicted

0.1992

0.6633

0.2994

1.7256

Q15078

CDK5R1

CyclinNonedependent kinase 5 activator 1

Predicted

0.1358

0.5004

0.2575

1.3263

P22001

KCNA3

Potassium voltageNonegated channel subfamily A member 3

Predicted

0.1396

0.5055

1.0809

P52732

KIF11

KinesinNonelike protein KIF11

Predicted

0.0082

0.8281

1.6602

P42338

PIK3CB

Phosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoform

Predicted

0.0447

0.9416

2.9055

P08235

NR3C2

Mineralocorticoid receptor

Predicted

0.1855

0.0137

2.1064

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

Q92769

HDAC2

Histone deacetylase 2

Predicted

0.0473

0.986

3.0097

P05186

ALPL

Alkaline phosphatase, tissueNonenonspecific isozyme

Predicted

0.3064

0.4143

0.1992

1.181

P22748

CA4

Carbonic anhydrase 4

Predicted

0.0056

0.8267

0.1609

1.8171

Q07343

PDE4B

cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B

Predicted

0.0253

0.9946

0.22

2.2219

P08183

ABCB1

ATPNonedependent translocase ABCB1

Predicted

0.0788

0.2052

2.2446

P09211

GSTP1

Glutathione SNonetransferase P

Predicted

0.3204

0.3523

0.4566

1.3213

Q13627

DYRK1A

Dual specificity tyrosineNonephosphorylationNoneregulated kinase 1A

Predicted

0.015

0.7082

1.4239

P31751

AKT2

RACNonebeta serine/threonineNoneprotein kinase

Predicted

0.4662

0.4856

2.2044

P43490

PBEF1

Nicotinamide phosphoribosyltransferase

Predicted

0.4423

0.7064

0.238

1.872

P23458

JAK1

TyrosineNoneprotein kinase JAK1

Predicted

0.5546

0.9211

3.1195

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

Q16875

PFKFB3

6NonephosphofructoNone2Nonekinase/fructoseNone2,6Nonebisphosphatase 3

Predicted

0.0462

0.0886

0.2342

0.4345

P51684

CCR6

CNoneC chemokine receptor type 6

Predicted

0.085

0.1741

0.3304

0.7212

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

O00141

SGK

Serine/threonineNoneprotein kinase Sgk1

Predicted

0.2413

0.3037

0.3059

1.034

Q02750

MAP2K1

Dual specificity mitogenNoneactivated protein kinase kinase 1

Predicted

0.312

0.5129

2.1819

P07900

HSP90AA1

Heat shock protein HSP 90Nonealpha

Predicted

0.4727

0.6064

0.741

2.1901

Q04759

PRKCQ

Protein kinase C theta type

Predicted

0.0405

0.4244

0.6173

1.4864

Q05655

PRKCD

Protein kinase C delta type

Predicted

0.0816

0.4194

0.6544

1.5339

O43451

MGAM

MaltaseNoneglucoamylase

Predicted

0.1954

0.1678

0.191

0.6242

P09619

PDGFRB

PlateletNonederived growth factor receptor beta

Predicted

0.0496

0.9444

0.7408

2.6543

P49759

CLK1

Dual specificity protein kinase CLK1

Predicted

0.2968

0.4546

0.1587

1.2163

P51617

IRAK1

InterleukinNone1 receptorNoneassociated kinase 1

Predicted

0.0238

0.3

0.9444

1.5563

Q96KQ7

EHMT2

HistoneNonelysine NNonemethyltransferase EHMT2

Predicted

0.0728

0.2165

0.2909

0.7603

Q02763

TEK

AngiopoietinNone1 receptor

Predicted

0.3206

0.6236

0.4304

1.8379

Q05397

PTK2

Focal adhesion kinase 1

Predicted

0.2153

0.5864

0.9713

2.2518

P04049

RAF1

RAF protoNoneoncogene serine/threonineNoneprotein kinase

Predicted

0.557

0.7572

2.7929

P20292

ALOX5AP

Arachidonate 5NonelipoxygenaseNoneactivating protein

Predicted

0.1303

0.2418

0.0907

0.6395

P00734

Prothrombin

Predicted

0.0963

0.707

0.4977

1.9598

O15164

TRIM24

Transcription intermediary factor 1Nonealpha

Predicted

0.2807

0.1055

0.3514

P19652

ORM2

AlphaNone1Noneacid glycoprotein 2

Predicted

0.0938

0.0579

0.1628

Gene name	UniProt_ID	Bioactivity	Value (nM)
TOP2A	P11388	IC50	1000
TOP2A	P11388	IC50	9940

PharmaCoNets of Amsacrine (SPCN: 266.53 )

Amsacrine regulated-network (SDN: 26.44)

Community members of Amsacrine (SDC: 10.08)

PharmaCoNets of Amsacrine (S_PCN: 266.53 )

Amsacrine regulated-network (S_DN: 26.44)

Community members of Amsacrine (S_DC: 10.08)