PharmaCoNets

PharmaCoNets of Amrinone (S_PCN: 210.31 )

Amrinone regulated-network (S_DN: 26.29)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Amrinone

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Amrinone

hsa00190

Oxidative phosphorylation

1.85E-04

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Amrinone

hsa00230

Purine metabolism

4.02E-02

P31350, P21589

RRM2, NT5E

Amrinone

hsa00240

Pyrimidine metabolism

2.54E-04

P31350, P21589, P04818

RRM2, NT5E, TYMS

Amrinone

hsa00310

Lysine degradation

2.89E-03

Q96KQ7, Q02809, P51648

EHMT2, PLOD1, ALDH3A2

Amrinone

hsa00480

Glutathione metabolism

3.29E-04

Q9UJ14, Q16772, P09211, P30041

GGTL3, GSTA3, GSTP1, PRDX6

Amrinone

hsa00500

Starch and sucrose metabolism

6.17E-03

O43451, P46976, P06737

MGAM, GYG1, PYGL

Amrinone

hsa00512

Mucin type O-glycan biosynthesis

4.86E-02

O95395, Q9NY28

GCNT3, GALNT8

Amrinone

hsa00520

Amino sugar and nucleotide sugar metabolism

1.59E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Amrinone

hsa00531

Glycosaminoglycan degradation

8.18E-04

P15586, P34059

GNS, GALNS

Amrinone

hsa00532

Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate

2.92E-02

Q9Y2C2

UST

Amrinone

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Amrinone

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Amrinone

hsa00603

Glycosphingolipid biosynthesis - globo and isoglobo series

7.10E-03

P06865, O75752

HEXA, B3GALNT1

Amrinone

hsa00630

Glyoxylate and dicarboxylate metabolism

1.20E-05

P40925, P40926, P15104

MDH1, MDH2, GLUL

Amrinone

hsa00640

Propanoate metabolism

3.83E-02

Q02252, Q9P2R7

ALDH6A1, SUCLA2

Amrinone

hsa00670

One carbon pool by folate

1.33E-02

P04818, Q99707

TYMS, MTR

Amrinone

hsa00730

Thiamine metabolism

2.27E-02

P05186, P24666

ALPL, ACP1

Amrinone

hsa00740

Riboflavin metabolism

4.77E-02

P30043

BLVRB

Amrinone

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Amrinone

hsa00790

Folate biosynthesis

1.04E-02

Q92820, P05186, P42330

GGH, ALPL, AKR1C3

Amrinone

hsa00860

Porphyrin and chlorophyll metabolism

4.14E-02

P53004

BLVRA

Amrinone

hsa00970

Aminoacyl-tRNA biosynthesis

2.12E-02

P14868

DARS

Amrinone

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-05

Q16772, P78417, P09211, P11712

GSTA3, GSTO1, GSTP1, CYP2C9

Amrinone

hsa00982

Drug metabolism - cytochrome P450

1.77E-04

P11712, Q16772, P09211, P78417

CYP2C9, GSTA3, GSTP1, GSTO1

Amrinone

hsa00983

Drug metabolism - other enzymes

2.42E-03

P04183, P32320, P05164, Q16772, P09211

TK1, CDA, MPO, GSTA3, GSTP1

Amrinone

hsa01100

Metabolic pathways

8.43E-03

P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6

CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1

Amrinone

hsa01523

Antifolate resistance

5.86E-05

P41440, Q92820, P04818, P01375

SLC19A1, GGH, TYMS, TNF

Amrinone

hsa01524

Platinum drug resistance

6.42E-03

Q16772, P09211, P31751

GSTA3, GSTP1, AKT2

Amrinone

hsa03008

Ribosome biogenesis in eukaryotes

2.06E-02

Q9NYH9, Q9BVP2

UTP6, GNL3

Amrinone

hsa03013

RNA transport

2.44E-03

P52298, Q09161, O14893, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, Q9BZI7, Q9Y6A5, Q06787

NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, UPF3B, TACC3, FMR1

Amrinone

hsa03015

mRNA surveillance pathway

4.81E-02

Q9BZI7, O94913

UPF3B, PCF11

Amrinone

hsa03040

Spliceosome

5.07E-06

Q14562, O43143, O60508, P17844, P08579, O75940, P51991, P61978, O75494, Q07955, Q01130, Q13243, P11142, O43447

DHX8, DHX15, CDC40, DDX5, SNRPB2, SMNDC1, HNRPA3, HNRPK, FUSIP1, SFRS1, SFRS2, SFRS5, HSPA8, PPIH

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.853
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.708
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.775
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.818
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.871
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O60508	CDC40	Pre-mRNA-processing factor 17	-0.837
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O60508	CDC40	Pre-mRNA-processing factor 17	0.716
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.73
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.702
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O75940	SMNDC1	Survival of motor neuron-related-splicing factor 30	0.786
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P51991	HNRPA3	Heterogeneous nuclear ribonucleoprotein A3	0.787
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.827
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O75494	FUSIP1	Serine/arginine-rich splicing factor 10	0.73
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.776
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.827
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.758
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.835
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.783
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.87
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.943
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.876
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.709
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.761

Amrinone

hsa03050

Proteasome

4.83E-02

P55036

PSMD4

Amrinone

hsa03320

PPAR signaling pathway

4.33E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Amrinone

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Amrinone

hsa04012

ErbB signaling pathway

1.91E-02

P16333, P19174, P01106

NCK1, PLCG1, MYC

Amrinone

hsa04014

Ras signaling pathway

8.94E-05

P31751, P20827, Q9NRA1, P49767, Q13009, P17252, P0DP23, P62873, P63218, P50151, P19174

AKT2, EFNA1, PDGFC, VEGFC, TIAM1, PRKCA, CALM1, GNB1, GNG5, GNG10, PLCG1

Amrinone

hsa04015

Rap1 signaling pathway

6.93E-03

P20827, Q9NRA1, P49767, P31751, P0DP23, P17252, P19174

EFNA1, PDGFC, VEGFC, AKT2, CALM1, PRKCA, PLCG1

Amrinone

hsa04020

Calcium signaling pathway

2.01E-02

P17252, P19174, P0DP23, P20020, Q9NRA1, P49767

PRKCA, PLCG1, CALM1, ATP2B1, PDGFC, VEGFC

Amrinone

hsa04022

cGMP-PKG signaling pathway

5.07E-03

P31751, P0DP23

AKT2, CALM1

Amrinone

hsa04024

cAMP signaling pathway

3.23E-03

P31751, P0DP23

AKT2, CALM1

Amrinone

hsa04061

Viral protein interaction with cytokine and cytokine receptor

3.29E-02

P09341, P25024, P25025, P47992, Q9UBD3, P01375

CXCL1, CXCR1, CXCR2, XCL1, XCL2, TNF

Amrinone

hsa04062

Chemokine signaling pathway

1.59E-03

P07948, P19174, P62873, P63218, P50151, Q13009, P14598, P42224, P25963

LYN, PLCG1, GNB1, GNG5, GNG10, TIAM1, NCF1, STAT1, NFKBIA

Amrinone

hsa04064

NF-kappa B signaling pathway

3.26E-05

P10415, Q13489, P25963, P51617, O00463, P01375, P29965, Q04759, Q9UDY8, Q13077, Q16548, Q8WV28, Q13315, P24522

BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, TNF, CD40LG, PRKCQ, MALT1, TRAF1, BCL2A1, BLNK, ATM, GADD45A

Amrinone

hsa04070

Phosphatidylinositol signaling system

3.21E-04

P19174, P0DP23, Q14643, P23743, P27987, P17252

PLCG1, CALM1, ITPR1, DGKA, ITPKB, PRKCA

Amrinone

hsa04071

Sphingolipid signaling pathway

1.30E-05

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2

Amrinone

hsa04080

Neuroactive ligand-receptor interaction

3.57E-04

P08311, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, P07550, P35318

CTSG, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, ADRB2, ADM

Amrinone

hsa04110

Cell cycle

2.90E-06

Q9UBD5, P06493, O60566, Q14683, P30304, P33981, P42773, P01106

ORC3, CDK1, BUB1B, SMC1A, CDC25A, TTK, CDKN2C, MYC

Amrinone

hsa04114

Oocyte meiosis

2.55E-04

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Amrinone

hsa04115

p53 signaling pathway

5.07E-03

P24522, Q13315, P31350, Q53FA7, P06493, O95067, P10415

GADD45A, ATM, RRM2, TP53I3, CDK1, CCNB2, BCL2

Amrinone

hsa04120

Ubiquitin mediated proteolysis

1.08E-03

Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669

SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12

Amrinone

hsa04141

Protein processing in endoplasmic reticulum

1.22E-04

P18848, P30101, Q15437, P60604, Q99941, P11142, P07900, P08238, Q9NR31, Q9H173, Q9UNL2

ATF4, PDIA3, SEC23B, UBE2G2, CREBL1, HSPA8, HSP90AA1, HSP90AB1, SAR1A, SIL1, SSR3

Amrinone

hsa04142

Lysosome

1.14E-02

P43234, P15586, P34059

CTSO, GNS, GALNS

Amrinone

hsa04145

Phagosome

5.41E-08

O75015, P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765

FCGR3B, ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q15722	LTB4R	Leukotriene B4 receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.737
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11215	ITGAM	Integrin alpha-M	-0.78
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q15080	NCF4	Neutrophil cytosol factor 4	-0.723
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
Q15722	LTB4R	Leukotriene B4 receptor 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.918
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P14598	NCF1	Neutrophil cytosol factor 1	-0.867
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.866
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13509	TUBB3	Tubulin beta-3 chain	-0.808
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13509	TUBB3	Tubulin beta-3 chain	0.789
P08246	ELA2	Neutrophil elastase	Q13509	TUBB3	Tubulin beta-3 chain	0.724
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P68371	TUBB2C	Tubulin beta-4B chain	-0.721
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P68371	TUBB2C	Tubulin beta-4B chain	0.741
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.883
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
Q15722	LTB4R	Leukotriene B4 receptor 1	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.717
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.759
P08246	ELA2	Neutrophil elastase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.71
Q15722	LTB4R	Leukotriene B4 receptor 1	P05164	MPO	Myeloperoxidase	0.805
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
Q15722	LTB4R	Leukotriene B4 receptor 1	O60603	TLR2	Toll-like receptor 2	0.942
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
Q15722	LTB4R	Leukotriene B4 receptor 1	P35443	THBS4	Thrombospondin-4	0.855
P08246	ELA2	Neutrophil elastase	P35443	THBS4	Thrombospondin-4	0.871
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
Q15722	LTB4R	Leukotriene B4 receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.792
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729

Amrinone

hsa04151

PI3K-Akt signaling pathway

1.53E-04

P62753, P25116, P27348, P49767, Q13362, P07900, P62873, P16144, P02452, P24821, P22105, O60603, P01568, Q99941, P18848, P10415, P17252, O00141

RPS6, F2R, YWHAQ, VEGFC, PPP2R5C, HSP90AA1, GNB1, ITGB4, COL1A1, TNC, TNXB, TLR2, IFNA21, CREBL1, ATF4, BCL2, PRKCA, SGK

Amrinone

hsa04210

Apoptosis

1.42E-03

Q13315, P04637, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, P43234, Q14643, P63261

ATM, TP53, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, CTSO, ITPR1, ACTG1

Amrinone

hsa04211

Longevity regulating pathway

2.72E-02

P51828, Q99941, P18848

ADCY7, CREBL1, ATF4

Amrinone

hsa04217

Necroptosis

7.03E-06

P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, P10415, O43633, Q08752

TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CHMP2A, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P01568	IFNA21	Interferon alpha-21	0.729
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P49760	CLK2	Dual specificity protein kinase CLK2	P01568	IFNA21	Interferon alpha-21	-0.752
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P49760	CLK2	Dual specificity protein kinase CLK2	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	0.741
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.912
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.826
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.75
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q93077	HIST1H2AC	Histone H2A type 1-C	0.715
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.881
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.728
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725

Amrinone

hsa04218

Cellular senescence

3.65E-03

P31751, P0DP23

AKT2, CALM1

Amrinone

hsa04261

Adrenergic signaling in cardiomyocytes

2.02E-04

P09493, P51828, P31751, Q99941, P18848, Q13362, P0DP23, Q13557, P17252, P10415

TPM1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, CALM1, CAMK2D, PRKCA, BCL2

Amrinone

hsa04270

Vascular smooth muscle contraction

3.82E-02

P24723, Q04759, Q14643, P22694, P35318

PRKCH, PRKCQ, ITPR1, PRKACB, ADM

Amrinone

hsa04310

Wnt signaling pathway

1.79E-02

P17612, P67870

PRKACA, CSNK2B

Amrinone

hsa04340

Hedgehog signaling pathway

3.91E-02

P17612

PRKACA

Amrinone

hsa04360

Axon guidance

2.29E-02

P16333, P20827, O95631, P17252, P19174

NCK1, EFNA1, NTN1, PRKCA, PLCG1

Amrinone

hsa04370

VEGF signaling pathway

1.30E-05

P16298, P31751, Q05397, Q02750

PPP3CB, AKT2, PTK2, MAP2K1

Amrinone

hsa04371

Apelin signaling pathway

5.24E-05

P62873, P63218, P50151, P31751, Q13370, Q14344, P84022, P0DP23

GNB1, GNG5, GNG10, AKT2, PDE3B, GNA13, SMAD3, CALM1

Amrinone

hsa04380

Osteoclast differentiation

2.72E-04

Q9NQC7, Q9UQC2, Q16539, P31751, P14778, O75015, P01375, Q8N149

CYLD, GAB2, MAPK14, AKT2, IL1R1, FCGR3B, TNF, LILRA2

Amrinone

hsa04390

Hippo signaling pathway

2.41E-02

P04628, O43623

WNT1, SNAI2

Amrinone

hsa04512

ECM-receptor interaction

7.53E-03

P02452, P24821

COL1A1, TNC

Amrinone

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Amrinone

hsa04540

Gap junction

1.65E-05

P17252, Q13509, P68371, Q71U36, Q9NRA1, Q14643

PRKCA, TUBB3, TUBB2C, TUBA1A, PDGFC, ITPR1

Amrinone

hsa04550

Signaling pathways regulating pluripotency of stem cells

4.73E-02

Q13873, Q02750, Q86SE9

BMPR2, MAP2K1, PCGF5

Amrinone

hsa04611

Platelet activation

2.12E-02

Q9Y490, P17612

TLN1, PRKACA

Amrinone

hsa04612

Antigen processing and presentation

1.71E-03

P13765, P48382, P26715, P26717, Q07444, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, TNF

Amrinone

hsa04613

Neutrophil extracellular trap formation

7.34E-07

P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
Q15722	LTB4R	Leukotriene B4 receptor 1	P17252	PRKCA	Protein kinase C alpha type	-0.757
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
Q15722	LTB4R	Leukotriene B4 receptor 1	O60603	TLR2	Toll-like receptor 2	0.942
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
Q15722	LTB4R	Leukotriene B4 receptor 1	P05164	MPO	Myeloperoxidase	0.805
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
Q15722	LTB4R	Leukotriene B4 receptor 1	P08246	ELA2	Neutrophil elastase	0.846
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.799
P08246	ELA2	Neutrophil elastase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.889
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
Q15722	LTB4R	Leukotriene B4 receptor 1	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.833
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
Q15722	LTB4R	Leukotriene B4 receptor 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.918
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P08246	ELA2	Neutrophil elastase	P20160	AZU1	Azurocidin	0.842
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
Q15722	LTB4R	Leukotriene B4 receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.737
Q15722	LTB4R	Leukotriene B4 receptor 1	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.875
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
Q15722	LTB4R	Leukotriene B4 receptor 1	P21462	FPR1	fMet-Leu-Phe receptor	0.888
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
Q15722	LTB4R	Leukotriene B4 receptor 1	O43315	AQP9	Aquaporin-9	0.79
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.721

Amrinone

hsa04620

Toll-like receptor signaling pathway

9.27E-04

Q13546, P01568, P31751

RIPK1, IFNA21, AKT2

Amrinone

hsa04621

NOD-like receptor signaling pathway

2.20E-04

Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P59665, P59666, P12838

ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4

Amrinone

hsa04622

RIG-I-like receptor signaling pathway

1.88E-04

P01568, Q9NQC7, Q13546

IFNA21, CYLD, RIPK1

Amrinone

hsa04623

Cytosolic DNA-sensing pathway

9.93E-06

P01568, Q13546, P25963

IFNA21, RIPK1, NFKBIA

Amrinone

hsa04625

C-type lectin receptor signaling pathway

2.27E-04

Q9ULY5, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539

CLEC4E, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14

Amrinone

hsa04640

Hematopoietic cell lineage

2.50E-03

P13612, P27930, P15144, P25063, P09693, P01732, P01730, P06127, P09564, P13765, P01375

ITGA4, IL1R2, ANPEP, CD24, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF

Amrinone

hsa04650

Natural killer cell mediated cytotoxicity

1.63E-06

P16298, P50591, P01375, P06239, O60880, P20963, Q02750, Q13241, P26718, O75015, P26717, Q07444, P26715

PPP3CB, TNFSF10, TNF, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC3, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P06239	LCK	Tyrosine-protein kinase Lck	0.769
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	O60880	SH2D1A	SH2 domain-containing protein 1A	0.922
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.881
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13241	KLRD1	Natural killer cells antigen CD94	0.941
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26718	KLRK1	NKG2-D type II integral membrane protein	0.858
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.716
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26717	KLRC2	NKG2-C type II integral membrane protein	0.915
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.718
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.915

Amrinone

hsa04657

IL-17 signaling pathway

1.16E-03

P25963, P08238, O00463, Q07955, Q16539, P49841, P14780, P04141, P01375, P06702

NFKBIA, HSP90AB1, TRAF5, SFRS1, MAPK14, GSK3B, MMP9, CSF2, TNF, S100A9

Amrinone

hsa04658

Th1 and Th2 cell differentiation

1.71E-04

Q04759, P20963, P09693, P06239, Q14765, P23771, Q9UL17, P13765, Q13761

PRKCQ, CD247, CD3G, LCK, STAT4, GATA3, TBX21, HLA-DOB, RUNX3

Amrinone

hsa04659

Th17 cell differentiation

7.72E-04

P25963, Q04759, P19174, P06239, P42224, P14784, P13765, Q9UL17, P23771, P84022, P08238, P09693, P20963

NFKBIA, PRKCQ, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, TBX21, GATA3, SMAD3, HSP90AB1, CD3G, CD247

Amrinone

hsa04660

T cell receptor signaling pathway

2.03E-04

P01375, P04141, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P19174, P16333, P20963, P09693, P01732, Q13191, P06239, P29350

TNF, CSF2, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, PLCG1, NCK1, CD247, CD3G, CD8A, CBLB, LCK, PTPN6

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P04141	CSF2	Granulocyte-macrophage colony-stimulating factor	0.757
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.739
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q04759	PRKCQ	Protein kinase C theta type	0.869
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.758
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P08246	ELA2	Neutrophil elastase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.724
P08246	ELA2	Neutrophil elastase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.782
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.808
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.739
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P16333	NCK1	Cytoplasmic protein NCK1	-0.703
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.881
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.731
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.892
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.795
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P06239	LCK	Tyrosine-protein kinase Lck	0.769
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.797

Amrinone

hsa04662

B cell receptor signaling pathway

1.60E-04

P31751, P42338, P60033, P07948, P21854, Q8N149

AKT2, PIK3CB, CD81, LYN, CD72, LILRA2

Amrinone

hsa04664

Fc epsilon RI signaling pathway

1.28E-05

P01375, P31751, P04141, Q16539, P42338, Q9UQC2, P07948, P19174, P09917

TNF, AKT2, CSF2, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5

Amrinone

hsa04668

TNF signaling pathway

1.83E-03

P01375, O00463, Q13489, Q16539, P25963, P20749, Q13077, P14780

TNF, TRAF5, BIRC3, MAPK14, NFKBIA, BCL3, TRAF1, MMP9

Amrinone

hsa04670

Leukocyte transendothelial migration

4.20E-02

P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681

MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK

Amrinone

hsa04672

Intestinal immune network for IgA production

3.76E-03

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Amrinone

hsa04713

Circadian entrainment

1.36E-04

P0DP23, P17252, P62873, P63218, P50151, Q14643, O15055

CALM1, PRKCA, GNB1, GNG5, GNG10, ITPR1, PER2

Amrinone

hsa04714

Thermogenesis

3.31E-02

P51828, P62753, P12074, O15239

ADCY7, RPS6, COX6A1, NDUFA1

Amrinone

hsa04720

Long-term potentiation

3.88E-04

P17252, P16298, P0DP23, P51812, Q02750, Q14643

PRKCA, PPP3CB, CALM1, RPS6KA3, MAP2K1, ITPR1

Amrinone

hsa04722

Neurotrophin signaling pathway

5.24E-05

Q05655, P31751, P49841, O43524, P48023, P52566, P0DP23

PRKCD, AKT2, GSK3B, FOXO3, FASLG, ARHGDIB, CALM1

Amrinone

hsa04723

Retrograde endocannabinoid signaling

8.76E-04

Q14643, P17252, P62873, P22694, Q16539, Q16718

ITPR1, PRKCA, GNB1, PRKACB, MAPK14, NDUFA5

Amrinone

hsa04724

Glutamatergic synapse

2.58E-04

O15399, P62873, P63218, P50151, P15104

GRIN2D, GNB1, GNG5, GNG10, GLUL

Amrinone

hsa04725

Cholinergic synapse

1.53E-04

P51828, Q14643, P17252, P62873, P63218, P50151, P18848, Q13557, P42338, P10415

ADCY7, ITPR1, PRKCA, GNB1, GNG5, GNG10, ATF4, CAMK2D, PIK3CB, BCL2

Amrinone

hsa04726

Serotonergic synapse

3.80E-02

P62873, P63218, P50151, P09917

GNB1, GNG5, GNG10, ALOX5

Amrinone

hsa04727

GABAergic synapse

1.66E-04

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Amrinone

hsa04728

Dopaminergic synapse

4.05E-04

Q14643, P17252, P62873, P31751, Q99941, P18848, Q13557, Q13362, P0DP23

ITPR1, PRKCA, GNB1, AKT2, CREBL1, ATF4, CAMK2D, PPP2R5C, CALM1

Amrinone

hsa04730

Long-term depression

4.86E-02

Q14344, P07948

GNA13, LYN

Amrinone

hsa04740

Olfactory transduction

2.41E-02

P0DP23

CALM1

Amrinone

hsa04742

Taste transduction

3.91E-02

P17612

PRKACA

Amrinone

hsa04744

Phototransduction

6.85E-07

P62873, P0DP23

GNB1, CALM1

Amrinone

hsa04910

Insulin signaling pathway

9.82E-04

P0DP23, P31751

CALM1, AKT2

Amrinone

hsa04911

Insulin secretion

4.03E-04

P51828, Q99941, P18848, Q13557

ADCY7, CREBL1, ATF4, CAMK2D

Amrinone

hsa04912

GnRH signaling pathway

6.37E-05

P17252, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP23, P22694

PRKCA, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM1, PRKACB

Amrinone

hsa04914

Progesterone-mediated oocyte maturation

5.17E-04

Q17RY0, Q9Y6D9, P51812, Q02750

CPEB4, MAD1L1, RPS6KA3, MAP2K1

Amrinone

hsa04915

Estrogen signaling pathway

1.04E-04

Q99941, P18848, P51828, P31751, P07900, P11142, P0DP23

CREBL1, ATF4, ADCY7, AKT2, HSP90AA1, HSPA8, CALM1

Amrinone

hsa04916

Melanogenesis

4.78E-02

P0DP23

CALM1

Amrinone

hsa04917

Prolactin signaling pathway

2.41E-02

P31751

AKT2

Amrinone

hsa04918

Thyroid hormone synthesis

1.69E-03

P51828, Q99941, P18848, P02768

ADCY7, CREBL1, ATF4, ALB

Amrinone

hsa04920

Adipocytokine signaling pathway

1.22E-02

P25963, P33121, Q04759, P31751, P01375

NFKBIA, ACSL1, PRKCQ, AKT2, TNF

Amrinone

hsa04922

Glucagon signaling pathway

2.33E-03

Q12778, P31751, Q13370, P0DP23, Q14643

FOXO1, AKT2, PDE3B, CALM1, ITPR1

Amrinone

hsa04923

Regulation of lipolysis in adipocytes

3.01E-02

P31751

AKT2

Amrinone

hsa04924

Renin secretion

1.31E-04

P22694, P07550, Q14643, Q13370, P0DP23

PRKACB, ADRB2, ITPR1, PDE3B, CALM1

Amrinone

hsa04925

Aldosterone synthesis and secretion

1.69E-03

Q99941, P18848, P51828, Q13557

CREBL1, ATF4, ADCY7, CAMK2D

Amrinone

hsa04926

Relaxin signaling pathway

5.00E-04

P42338, P63218, P50151, Q99941, P18848, P49767, P51828, P49407

PIK3CB, GNG5, GNG10, CREBL1, ATF4, VEGFC, ADCY7, ARRB1

Amrinone

hsa04927

Cortisol synthesis and secretion

4.16E-03

Q99941, P18848, P51828

CREBL1, ATF4, ADCY7

Amrinone

hsa04928

Parathyroid hormone synthesis, secretion and action

3.47E-03

Q14643, P51828, P22694, P23771, P17252, Q99941, P18848, P10415

ITPR1, ADCY7, PRKACB, GATA3, PRKCA, CREBL1, ATF4, BCL2

Amrinone

hsa04929

GnRH secretion

3.61E-03

P42338, P31751, P49407

PIK3CB, AKT2, ARRB1

Amrinone

hsa04930

Type II diabetes mellitus

2.68E-02

Q05655

PRKCD

Amrinone

hsa04932

Non-alcoholic fatty liver disease

2.74E-02

P01375, P49841, P48023

TNF, GSK3B, FASLG

Amrinone

hsa04933

AGE-RAGE signaling pathway in diabetic complications

6.00E-04

P42224, P10415, Q12778, P49767, P17252, P19174

STAT1, BCL2, FOXO1, VEGFC, PRKCA, PLCG1

Amrinone

hsa04934

Cushing syndrome

1.12E-03

Q99941, P18848, P51828, Q13557

CREBL1, ATF4, ADCY7, CAMK2D

Amrinone

hsa04935

Growth hormone synthesis, secretion and action

2.72E-02

P51828, Q99941, P18848

ADCY7, CREBL1, ATF4

Amrinone

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Amrinone

hsa04966

Collecting duct acid secretion

2.86E-02

Q13488, Q9Y666

TCIRG1, SLC12A7

Amrinone

hsa04970

Salivary secretion

1.22E-02

P22694, Q14643, P17252, P0DP23, P49913

PRKACB, ITPR1, PRKCA, CALM1, CAMP

Amrinone

hsa04971

Gastric acid secretion

4.78E-02

P0DP23

CALM1

Amrinone

hsa04973

Carbohydrate digestion and absorption

2.41E-02

P31751

AKT2

Amrinone

hsa04974

Protein digestion and absorption

2.78E-02

P02452

COL1A1

Amrinone

hsa05010

Alzheimer disease

7.72E-03

Q16718, O14521, Q14643, Q00535, P0DP23, Q13509, P68371, P31751, Q08752

NDUFA5, SDHD, ITPR1, CDK5, CALM1, TUBB3, TUBB2C, AKT2, PPID

Amrinone

hsa05012

Parkinson disease

1.17E-04

Q16718, O14521, P60604, Q14643, P19174, P0DP23, Q71U36, Q13509, P68371

NDUFA5, SDHD, UBE2G2, ITPR1, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2C

Amrinone

hsa05020

Prion disease

1.15E-02

Q16718, O14521, Q14643, Q13509, P68371, P14598, Q15080

NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, NCF1, NCF4

Amrinone

hsa05022

Pathways of neurodegeneration - multiple diseases

5.02E-04

Q14643, Q13509, P68371, P10415, Q16718, O14521, Q13561, P19174, P17252, Q00535, Q08752, P0DP23

ITPR1, TUBB3, TUBB2C, BCL2, NDUFA5, SDHD, DCTN2, PLCG1, PRKCA, CDK5, PPID, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13509	TUBB3	Tubulin beta-3 chain	-0.808
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P68371	TUBB2C	Tubulin beta-4B chain	-0.721
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.812
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.712
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13561	DCTN2	Dynactin subunit 2	-0.744
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.739
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P17252	PRKCA	Protein kinase C alpha type	0.832
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P31751	AKT2	RAC-beta serine/threonine-protein kinase	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.726
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.728
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P0DP23	CALM1	Calmodulin-1	-0.761
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761

Amrinone

hsa05030

Cocaine addiction

6.96E-03

Q00535, Q99941, P18848

CDK5, CREBL1, ATF4

Amrinone

hsa05031

Amphetamine addiction

9.24E-04

P0DP23, Q13557, Q99941, P18848

CALM1, CAMK2D, CREBL1, ATF4

Amrinone

hsa05032

Morphine addiction

2.18E-02

P62873, P63218, P50151, Q13370

GNB1, GNG5, GNG10, PDE3B

Amrinone

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Amrinone

hsa05100

Bacterial invasion of epithelial cells

3.14E-03

Q14141, Q05397, Q96JJ3

SEPT6, PTK2, ELMO2

Amrinone

hsa05110

Vibrio cholerae infection

2.61E-04

Q13488, Q99437, P17252, P19174, P17612

TCIRG1, ATP6V0B, PRKCA, PLCG1, PRKACA

Amrinone

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

1.08E-02

P25963, Q13488, P19174, P07948

NFKBIA, TCIRG1, PLCG1, LYN

Amrinone

hsa05130

Pathogenic Escherichia coli infection

3.19E-02

Q71U36, P16333, Q13509, P68371, Q14344, P25963

TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIA

Amrinone

hsa05131

Shigellosis

6.61E-05

P01375, P25963, O00463, P68431, Q05655, Q04759, Q9UDY8, Q9NQL2, Q9H1Y0, P0CG47, Q14141, Q14247, Q96JJ3, Q05397, Q14643, Q12778, Q13315, P10415, Q08752, Q96A32, P07737

TNF, NFKBIA, TRAF5, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCD, PRKCQ, MALT1, RRAGD, ATG5, UBB, SEPT6, CTTN, ELMO2, PTK2, ITPR1, FOXO1, ATM, BCL2, PPID, MYLPF, PFN1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
Q05655	PRKCD	Protein kinase C delta type	Q05655	PRKCD	Protein kinase C delta type	1
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.88
P08246	ELA2	Neutrophil elastase	Q9H1Y0	ATG5	Autophagy protein 5	-0.759
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	P0CG47	UBB	Polyubiquitin-B	-0.875
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q14141	SEPT6	Septin-6	-0.81
P17252	PRKCA	Protein kinase C alpha type	Q14247	CTTN	Src substrate cortactin	0.771
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.912
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q05397	PTK2	Focal adhesion kinase 1	0.932
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P08246	ELA2	Neutrophil elastase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.816
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q13315	ATM	Serine-protein kinase ATM	-0.748
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08246	ELA2	Neutrophil elastase	Q96A32	MYLPF	Myosin regulatory light chain 2, skeletal muscle isoform	0.724
Q05655	PRKCD	Protein kinase C delta type	P07737	PFN1	Profilin-1	0.77

Amrinone

hsa05132

Salmonella infection

6.81E-06

P51617, P25963, P01375, P08238, Q9UJU2, P84095, Q13489, P10415, P04406, O75369, P07737, Q96A32, O60603, Q9BQS8, Q13561, Q71U36, Q13509, P68371, P49754

IRAK1, NFKBIA, TNF, HSP90AB1, LEF1, RHOG, BIRC3, BCL2, GAPDH, FLNB, PFN1, MYLPF, TLR2, FYCO1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.739
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.826
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P08246	ELA2	Neutrophil elastase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.771
Q05655	PRKCD	Protein kinase C delta type	P84095	RHOG	Rho-related GTP-binding protein RhoG	0.71
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	-0.76
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O75369	FLNB	Filamin-B	-0.715
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75369	FLNB	Filamin-B	0.706
Q05655	PRKCD	Protein kinase C delta type	P07737	PFN1	Profilin-1	0.77
P08246	ELA2	Neutrophil elastase	Q96A32	MYLPF	Myosin regulatory light chain 2, skeletal muscle isoform	0.724
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
P08246	ELA2	Neutrophil elastase	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	-0.949
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13561	DCTN2	Dynactin subunit 2	-0.744
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P08246	ELA2	Neutrophil elastase	Q13561	DCTN2	Dynactin subunit 2	0.78
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.866
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13509	TUBB3	Tubulin beta-3 chain	-0.808
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13509	TUBB3	Tubulin beta-3 chain	0.789
P08246	ELA2	Neutrophil elastase	Q13509	TUBB3	Tubulin beta-3 chain	0.724
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P68371	TUBB2C	Tubulin beta-4B chain	-0.721
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P68371	TUBB2C	Tubulin beta-4B chain	0.741
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	-0.718
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.728

Amrinone

hsa05134

Legionellosis

4.75E-02

P25963, P11215, P11142

NFKBIA, ITGAM, HSPA8

Amrinone

hsa05135

Yersinia infection

3.29E-02

Q05397, P51812, Q02750, Q96JJ3

PTK2, RPS6KA3, MAP2K1, ELMO2

Amrinone

hsa05140

Leishmaniasis

9.47E-07

P14598, P11215, P42224, P13765, O60603, P25963, P01375, P29350, P51617, Q15080

NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, IRAK1, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P14598	NCF1	Neutrophil cytosol factor 1	-0.867
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11215	ITGAM	Integrin alpha-M	-0.78
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.912
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.739
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.797
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q15080	NCF4	Neutrophil cytosol factor 4	-0.723
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945

Amrinone

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Amrinone

hsa05144

Malaria

3.12E-02

P60033, P01375, P35443, P26718

CD81, TNF, THBS4, KLRK1

Amrinone

hsa05145

Toxoplasmosis

1.19E-03

P51617, P25963, P01375, P10415, Q13489, P42224, P13765, O60603, P29965

IRAK1, NFKBIA, TNF, BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG

Amrinone

hsa05146

Amoebiasis

5.91E-03

P09341, P27930, P01375, P05089, P22694, P12814, P08311

CXCL1, IL1R2, TNF, ARG1, PRKACB, ACTN1, CTSG

Amrinone

hsa05150

Staphylococcus aureus infection

6.29E-05

P21730, P21462, O75015, Q14532, P59665, P59666, P12838, P49913

C5AR1, FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Amrinone

hsa05152

Tuberculosis

4.99E-06

Q13488, P0DP23, O75015, P42224, P48382, O60603, P01375, P31751, P10415, P13765, P01568, P49913, Q9UDY8, Q16539, P51617

TCIRG1, CALM1, FCGR3B, STAT1, RFX5, TLR2, TNF, AKT2, BCL2, HLA-DOB, IFNA21, CAMP, MALT1, MAPK14, IRAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
Q15722	LTB4R	Leukotriene B4 receptor 1	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.717
P08246	ELA2	Neutrophil elastase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.71
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
Q15722	LTB4R	Leukotriene B4 receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.737
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
Q15722	LTB4R	Leukotriene B4 receptor 1	P48382	RFX5	DNA-binding protein RFX5	-0.779
P08246	ELA2	Neutrophil elastase	P48382	RFX5	DNA-binding protein RFX5	-0.895
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
Q15722	LTB4R	Leukotriene B4 receptor 1	O60603	TLR2	Toll-like receptor 2	0.942
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q15722	LTB4R	Leukotriene B4 receptor 1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.865
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
Q15722	LTB4R	Leukotriene B4 receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.792
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.843
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.721
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734

Amrinone

hsa05160

Hepatitis C

1.19E-03

Q13546, P01568, P60033, P49841, P01375, P48023

RIPK1, IFNA21, CD81, GSK3B, TNF, FASLG

Amrinone

hsa05161

Hepatitis B

2.41E-03

P17252, P14780, Q99941, P18848, P25963, P01375, P10415, P27348, P51617, O60603, Q14765

PRKCA, MMP9, CREBL1, ATF4, NFKBIA, TNF, BCL2, YWHAQ, IRAK1, TLR2, STAT4

Amrinone

hsa05163

Human cytomegalovirus infection

1.16E-04

P31751, P01375, P25963, P62873, P63218, P50151, P0DP23, Q14344, P49841, P14778, P25025, Q16539, O00463, P30101, P01568

AKT2, TNF, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5, PDIA3, IFNA21

Amrinone

hsa05165

Human papillomavirus infection

9.67E-04

P16144, P02452, P24821, Q05086, P01568, P42224, Q13488, Q13362, Q12778, P04628, Q13315

ITGB4, COL1A1, TNC, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, WNT1, ATM

Amrinone

hsa05167

Kaposi sarcoma-associated herpesvirus infection

5.03E-08

P01568, P31751, P42224, P25963, P40189, P62873, P63218, P50151, P19174, Q14643, P07948, P04141, P0DP23, Q9UJU2

IFNA21, AKT2, STAT1, NFKBIA, IL6ST, GNB1, GNG5, GNG10, PLCG1, ITPR1, LYN, CSF2, CALM1, LEF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P01568	IFNA21	Interferon alpha-21	0.729
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.912
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.739
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P40189	IL6ST	Interleukin-6 receptor subunit beta	-0.746
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.833
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.739
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P04141	CSF2	Granulocyte-macrophage colony-stimulating factor	0.757
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P04141	CSF2	Granulocyte-macrophage colony-stimulating factor	-0.79
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P0DP23	CALM1	Calmodulin-1	-0.761
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881

Amrinone

hsa05168

Herpes simplex virus 1 infection

9.87E-05

P25963, P01568, Q9GZY0, P42224, Q07955, Q01130, Q13243, P30101, Q9Y2A4, Q13398, P51522, P17038, Q03923, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, ZNF443, ZNF211, ZNF83, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.739
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.825
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P01568	IFNA21	Interferon alpha-21	0.729
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	0.704
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.912
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.776
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.827
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.703
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.758
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.783
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.781
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.87
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.943
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q9Y2A4	ZNF443	Zinc finger protein 443	0.731
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13398	ZNF211	Zinc finger protein 211	-0.759
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13398	ZNF211	Zinc finger protein 211	0.849
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P51522	ZNF83	Zinc finger protein 83	0.851
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P17038	ZNF43	Zinc finger protein 43	0.718
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q03923	ZNF85	Zinc finger protein 85	0.79
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P52738	ZNF140	Zinc finger protein 140	0.717
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P52738	ZNF140	Zinc finger protein 140	0.71
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O75820	ZNF189	Zinc finger protein 189	0.715
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75820	ZNF189	Zinc finger protein 189	-0.766
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	O75820	ZNF189	Zinc finger protein 189	0.768
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q9UDV6	ZNF212	Zinc finger protein 212	-0.808

Amrinone

hsa05169

Epstein-Barr virus infection

3.72E-02

Q13547, P42338, P07948, Q13761, O75293, P07766

HDAC1, PIK3CB, LYN, RUNX3, GADD45B, CD3E

Amrinone

hsa05170

Human immunodeficiency virus 1 infection

9.14E-09

P31751, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, P01375, Q05397, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P19174, P10415, Q13619, Q93034, Q9Y6Q5

AKT2, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, TNF, PTK2, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, BCL2, CUL4A, CUL5, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.93
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.96
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.93
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q05397	PTK2	Focal adhesion kinase 1	0.932
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P08246	ELA2	Neutrophil elastase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.816
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q13315	ATM	Serine-protein kinase ATM	-0.748
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08246	ELA2	Neutrophil elastase	O95067	CCNB2	G2/mitotic-specific cyclin-B2	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	Q13619	CUL4A	Cullin-4A	-0.707
P08246	ELA2	Neutrophil elastase	Q93034	CUL5	Cullin-5	-0.744
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
P08246	ELA2	Neutrophil elastase	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.811

Amrinone

hsa05171

Coronavirus disease - COVID-19

1.36E-02

P25963, P42224, P01568, P40189, P04141, P19174, P17252

NFKBIA, STAT1, IFNA21, IL6ST, CSF2, PLCG1, PRKCA

Amrinone

hsa05200

Pathways in cancer

4.31E-06

P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P84022, P20585, P14923, P10415, Q13489, P49767, Q12778, P31751, P25116, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784, P40189

HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, SMAD3, MSH3, JUP, BCL2, BIRC3, VEGFC, FOXO1, AKT2, F2R, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB, IL6ST

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.826
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.912
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.739
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.739
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P17252	PRKCA	Protein kinase C alpha type	0.832
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P43246	MSH2	DNA mismatch repair protein Msh2	-0.768
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P43246	MSH2	DNA mismatch repair protein Msh2	0.816
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P20585	MSH3	DNA mismatch repair protein Msh3	0.825
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P14923	JUP	Junction plakoglobin	0.735
P17252	PRKCA	Protein kinase C alpha type	P14923	JUP	Junction plakoglobin	0.761
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P49767	VEGFC	Vascular endothelial growth factor C	0.761
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q12778	FOXO1	Forkhead box protein O1	0.753
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.833
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.713
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.742
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P0DP23	CALM1	Calmodulin-1	-0.761
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P01568	IFNA21	Interferon alpha-21	0.729
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P40189	IL6ST	Interleukin-6 receptor subunit beta	-0.746

Amrinone

hsa05202

Transcriptional misregulation in cancer

1.57E-07

Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522

FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q15722	LTB4R	Leukotriene B4 receptor 1	Q12778	FOXO1	Forkhead box protein O1	-0.769
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
Q15722	LTB4R	Leukotriene B4 receptor 1	Q15532	SS18	Protein SSXT	-0.803
P08246	ELA2	Neutrophil elastase	Q15532	SS18	Protein SSXT	-0.806
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
Q15722	LTB4R	Leukotriene B4 receptor 1	P41732	TSPAN7	Tetraspanin-7	0.775
Q15722	LTB4R	Leukotriene B4 receptor 1	P14780	MMP9	Matrix metalloproteinase-9	0.861
P08246	ELA2	Neutrophil elastase	P14780	MMP9	Matrix metalloproteinase-9	0.859
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P14780	MMP9	Matrix metalloproteinase-9	-0.869
Q15722	LTB4R	Leukotriene B4 receptor 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.734
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P27930	IL1R2	Interleukin-1 receptor type 2	-0.813
P08246	ELA2	Neutrophil elastase	P14923	JUP	Junction plakoglobin	-0.811
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.844
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16548	BCL2A1	Bcl-2-related protein A1	0.837
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q16548	BCL2A1	Bcl-2-related protein A1	-0.762
Q15722	LTB4R	Leukotriene B4 receptor 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.797
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
Q15722	LTB4R	Leukotriene B4 receptor 1	O15550	UTX	Lysine-specific demethylase 6A	0.789
Q15722	LTB4R	Leukotriene B4 receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.779
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
Q15722	LTB4R	Leukotriene B4 receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.779
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
Q15722	LTB4R	Leukotriene B4 receptor 1	P05164	MPO	Myeloperoxidase	0.805
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P05164	MPO	Myeloperoxidase	-0.867
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P12838	DEFA4	Neutrophil defensin 4	-0.852
Q15722	LTB4R	Leukotriene B4 receptor 1	P08246	ELA2	Neutrophil elastase	0.846
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08246	ELA2	Neutrophil elastase	-0.742
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.808
P08246	ELA2	Neutrophil elastase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.75
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.822
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13547	HDAC1	Histone deacetylase 1	0.83
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P12980	LYL1	Protein lyl-1	-0.73
Q15722	LTB4R	Leukotriene B4 receptor 1	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.764
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.787

Amrinone

hsa05203

Viral carcinogenesis

3.37E-04

Q12933, Q99941, P18848, P42229, P27348, Q15283, P61978, P62807, O60814

TRAF2, CREBL1, ATF4, STAT5A, YWHAQ, RASA2, HNRPK, HIST1H2BC, H2BC12

Amrinone

hsa05204

Chemical carcinogenesis

1.77E-04

Q16772, P09211, P78417, P11712

GSTA3, GSTP1, GSTO1, CYP2C9

Amrinone

hsa05205

Proteoglycans in cancer

4.43E-02

P63261, P04637, Q06124

ACTG1, TP53, PTPN11

Amrinone

hsa05211

Renal cell carcinoma

1.47E-03

Q06124, Q99814, P31751

PTPN11, EPAS1, AKT2

Amrinone

hsa05212

Pancreatic cancer

9.02E-04

P31751, P42224, P84022, P04637, P24522, O75293

AKT2, STAT1, SMAD3, TP53, GADD45A, GADD45B

Amrinone

hsa05213

Endometrial cancer

2.28E-03

P31751, P04637, P24522

AKT2, TP53, GADD45A

Amrinone

hsa05214

Glioma

3.47E-06

P0DP23, P17252, P31751, P04637, P19174, P24522, O75293

CALM1, PRKCA, AKT2, TP53, PLCG1, GADD45A, GADD45B

Amrinone

hsa05216

Thyroid cancer

1.14E-02

P04637, P24522

TP53, GADD45A

Amrinone

hsa05217

Basal cell carcinoma

2.06E-02

P04637, P24522

TP53, GADD45A

Amrinone

hsa05218

Melanoma

8.68E-04

P04637, P31751, P24522

TP53, AKT2, GADD45A

Amrinone

hsa05220

Chronic myeloid leukemia

5.62E-04

Q06124, P04637, P31751, P24522

PTPN11, TP53, AKT2, GADD45A

Amrinone

hsa05221

Acute myeloid leukemia

4.19E-02

P31751

AKT2

Amrinone

hsa05222

Small cell lung cancer

5.10E-03

P31751, Q13489, P10415, P25963, Q13077, O00463, P24522

AKT2, BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A

Amrinone

hsa05223

Non-small cell lung cancer

1.84E-03

P31751, P04637, P24522

AKT2, TP53, GADD45A

Amrinone

hsa05224

Breast cancer

4.51E-02

P04637, P24522

TP53, GADD45A

Amrinone

hsa05225

Hepatocellular carcinoma

3.30E-02

P04637, P24522, P63261

TP53, GADD45A, ACTG1

Amrinone

hsa05226

Gastric cancer

3.60E-02

P31751

AKT2

Amrinone

hsa05230

Central carbon metabolism in cancer

4.78E-02

P31751

AKT2

Amrinone

hsa05231

Choline metabolism in cancer

1.61E-04

Q9NRA1, Q9Y259, P19174, P23743, P49619, P17252

PDGFC, CHKB, PLCG1, DGKA, DGKG, PRKCA

Amrinone

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

2.97E-02

P25963, P19174, P29350, P42224, P10747

NFKBIA, PLCG1, PTPN6, STAT1, CD28

Amrinone

hsa05310

Asthma

1.22E-03

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Amrinone

hsa05320

Autoimmune thyroid disease

1.27E-03

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Amrinone

hsa05321

Inflammatory bowel disease

1.95E-05

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Amrinone

hsa05322

Systemic lupus erythematosus

3.69E-07

O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P12814, P05455

FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1, SSB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.716
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08246	ELA2	Neutrophil elastase	-0.742
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08311	CTSG	Cathepsin G	-0.898
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q16778	HIST2H2BE	Histone H2B type 2-E	-0.712
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P12814	ACTN1	Alpha-actinin-1	-0.76
P08246	ELA2	Neutrophil elastase	P05455	SSB	Lupus La protein	-0.717

Amrinone

hsa05323

Rheumatoid arthritis

1.29E-02

P13765, Q13488, P10747, O60603

HLA-DOB, TCIRG1, CD28, TLR2

Amrinone

hsa05330

Allograft rejection

1.04E-03

P13765, P29965, P48023, P10747, P01375

HLA-DOB, CD40LG, FASLG, CD28, TNF

Amrinone

hsa05332

Graft-versus-host disease

1.31E-06

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Amrinone

hsa05415

Diabetic cardiomyopathy

1.23E-03

P17252, P14598, Q15080, Q16718, O14521, P04406

PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDH

Amrinone

hsa05416

Viral myocarditis

2.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Amrinone

hsa05418

Fluid shear stress and atherosclerosis

6.43E-05

Q16539, P31751, Q14145, P10599, P14780, P01375, P14778, P27930, P0DP23

MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2, CALM1

Community members of Amrinone (S_DC: 8.00)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

TNF

Tumor necrosis factor

Reported

0.1865

0.551

2.1953

Q13370

PDE3B

cGMPNoneinhibited 3',5'Nonecyclic phosphodiesterase B

Reported

0.0906

0.1614

0.3558

0.7239

Q07343

PDE4B

cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B

Reported

0.0253

0.9946

0.22

2.2219

P33981

TTK

Dual specificity protein kinase TTK

Predicted

0.0039

0.5805

0.259

1.422

Q15078

CDK5R1

CyclinNonedependent kinase 5 activator 1

Predicted

0.1358

0.5004

0.2575

1.3263

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

P07900

HSP90AA1

Heat shock protein HSP 90Nonealpha

Predicted

0.4727

0.6064

0.741

2.1901

P04818

TYMS

Thymidylate synthase

Predicted

0.4553

0.2706

0.1893

0.9582

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

Q05397

PTK2

Focal adhesion kinase 1

Predicted

0.2153

0.5864

0.9713

2.2518

P08238

HSP90AB1

Heat shock protein HSP 90Nonebeta

Predicted

0.0611

0.5208

0.741

1.8131

P42338

PIK3CB

Phosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoform

Predicted

0.0447

0.9416

2.9055

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P15121

AKR1B1

AldoNoneketo reductase family 1 member B1

Predicted

0.5683

0.629

0.214

1.7562

P17612

PRKACA

cAMPNonedependent protein kinase catalytic subunit alpha

Predicted

0.6937

0.5257

2.3982

Q9Y4K0

LOXL2

Lysyl oxidase homolog 2

Predicted

0.0269

0.1198

0.253

Q13627

DYRK1A

Dual specificity tyrosineNonephosphorylationNoneregulated kinase 1A

Predicted

0.015

0.7082

1.4239

Q92630

DYRK2

Dual specificity tyrosineNonephosphorylationNoneregulated kinase 2

Predicted

0.1779

0.3494

0.7877

P49759

CLK1

Dual specificity protein kinase CLK1

Predicted

0.2968

0.4546

0.1587

1.2163

P49760

CLK2

Dual specificity protein kinase CLK2

Predicted

0.0303

0.2951

0.6053

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

P31751

AKT2

RACNonebeta serine/threonineNoneprotein kinase

Predicted

0.4662

0.4856

2.2044

P08246

ELA2

Neutrophil elastase

Predicted

0.496

0.6844

0.7132

2.33

P06493

CDK1

CyclinNonedependent kinase 1

Predicted

0.013

0.604

2.6105

P17252

PRKCA

Protein kinase C alpha type

Predicted

0.1409

0.6948

2.4601

Q05655

PRKCD

Protein kinase C delta type

Predicted

0.0816

0.4194

0.6544

1.5339

P51812

RPS6KA3

Ribosomal protein S6 kinase alphaNone3

Predicted

0.2865

0.3936

0.4146

1.345

Q15722

LTB4R

Leukotriene B4 receptor 1

Predicted

0.0677

0.2199

0.4736

Gene name	UniProt_ID	Bioactivity	Value (nM)
PDE4B	Q07343	IC50	41000
PDE4B	Q07343	IC50	101000
PDE4B	Q07343	IC50	126000

PharmaCoNets of Amrinone (SPCN: 210.31 )

Amrinone regulated-network (SDN: 26.29)

Community members of Amrinone (SDC: 8.00)

PharmaCoNets of Amrinone (S_PCN: 210.31 )

Amrinone regulated-network (S_DN: 26.29)

Community members of Amrinone (S_DC: 8.00)