PharmaCoNets of Amodiaquine (SPCN: 38.31 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Amodiaquinehsa00500Starch and sucrose metabolism1.79E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Amodiaquinehsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Amodiaquinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Amodiaquinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Amodiaquinehsa00730Thiamine metabolism4.66E-022P05186, P24666ALPL, ACP1More
Amodiaquinehsa00770Pantothenate and CoA biosynthesis2.26E-043O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Amodiaquinehsa00970Aminoacyl-tRNA biosynthesis4.54E-043O95363, P54136, Q15046FARS2, RARS1, KARSMore
Amodiaquinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Amodiaquinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Amodiaquinehsa01522Endocrine resistance4.74E-023P22694, P10415, Q13323PRKACB, BCL2, BIKMore
Amodiaquinehsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Amodiaquinehsa03040Spliceosome1.28E-0513O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Amodiaquinehsa03320PPAR signaling pathway4.33E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Amodiaquinehsa04014Ras signaling pathway2.36E-028P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Amodiaquinehsa04015Rap1 signaling pathway1.79E-028P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1More
Amodiaquinehsa04062Chemokine signaling pathway1.43E-0417P25024, P25025, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P49841, Q8WYR1CXCR1, CXCR2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, GSK3B, PIK3R5More
Amodiaquinehsa04080Neuroactive ligand-receptor interaction4.90E-036P08311, Q15722, P21453, Q9H228, O00398, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, ADRB2More
Amodiaquinehsa04110Cell cycle6.63E-046P06493, O60566, P30304, P33981, P42773, P01106CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYCMore
Amodiaquinehsa04114Oocyte meiosis6.23E-035Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Amodiaquinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Amodiaquinehsa04140Autophagy - animal4.74E-023P22694, Q14643, P10415PRKACB, ITPR1, BCL2More
Amodiaquinehsa04151PI3K-Akt signaling pathway3.70E-0212P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3More
Amodiaquinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Amodiaquinehsa04340Hedgehog signaling pathway9.74E-033P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Amodiaquinehsa04360Axon guidance4.04E-026P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Amodiaquinehsa04370VEGF signaling pathway3.06E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Amodiaquinehsa04371Apelin signaling pathway1.00E-027P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Amodiaquinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Amodiaquinehsa04540Gap junction2.86E-023P22694, P68371, Q14643PRKACB, TUBB2C, ITPR1More
Amodiaquinehsa04550Signaling pathways regulating pluripotency of stem cells4.73E-023Q13873, Q02750, Q86SE9BMPR2, MAP2K1, PCGF5More
Amodiaquinehsa04613Neutrophil extracellular trap formation1.73E-024Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Amodiaquinehsa04640Hematopoietic cell lineage4.95E-023P01730, P06127, P09564CD4, CD5, CD7More
Amodiaquinehsa04650Natural killer cell mediated cytotoxicity8.23E-0512P16298, P50591, P01375, P06239, O60880, P20963, Q02750, Q13241, P26718, O75015, P26717, P26715PPP3CB, TNFSF10, TNF, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Amodiaquinehsa04659Th17 cell differentiation1.70E-027P19174, P14784, P14778, P84022, Q13485, P08238, P07766PLCG1, IL2RB, IL1R1, SMAD3, SMAD4, HSP90AB1, CD3EMore
Amodiaquinehsa04660T cell receptor signaling pathway2.78E-027P01375, Q08881, P20963, Q13191, P06239, Q16539, P49841TNF, ITK, CD247, CBLB, LCK, MAPK14, GSK3BMore
Amodiaquinehsa04662B cell receptor signaling pathway1.74E-025P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Amodiaquinehsa04664Fc epsilon RI signaling pathway2.47E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Amodiaquinehsa04720Long-term potentiation2.85E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Amodiaquinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Amodiaquinehsa04725Cholinergic synapse3.74E-023P22694, Q14643, P10415PRKACB, ITPR1, BCL2More
Amodiaquinehsa04728Dopaminergic synapse2.82E-026P14416, P63218, P50151, P49841, Q16539, P49407DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1More
Amodiaquinehsa04913Ovarian steroidogenesis2.72E-022P42330, P22694AKR1C3, PRKACBMore
Amodiaquinehsa04914Progesterone-mediated oocyte maturation1.00E-024Q17RY0, Q9Y6D9, P51812, Q02750CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Amodiaquinehsa04924Renin secretion3.09E-033P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Amodiaquinehsa04927Cortisol synthesis and secretion2.72E-022Q14643, P22694ITPR1, PRKACBMore
Amodiaquinehsa04928Parathyroid hormone synthesis, secretion and action1.02E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Amodiaquinehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Amodiaquinehsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Amodiaquinehsa04934Cushing syndrome4.74E-023Q14643, P22694, P04628ITPR1, PRKACB, WNT1More
Amodiaquinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Amodiaquinehsa04970Salivary secretion2.11E-023P07550, P22694, Q14643ADRB2, PRKACB, ITPR1More
Amodiaquinehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Amodiaquinehsa05100Bacterial invasion of epithelial cells2.85E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Amodiaquinehsa05120Epithelial cell signaling in Helicobacter pylori infection3.11E-024Q16539, P25024, P25025, P07948MAPK14, CXCR1, CXCR2, LYNMore
Amodiaquinehsa05135Yersinia infection6.38E-039Q05397, P51812, P13612, P06239, Q16539, Q02750, P01375, P49841, Q96JJ3PTK2, RPS6KA3, ITGA4, LCK, MAPK14, MAP2K1, TNF, GSK3B, ELMO2More
Amodiaquinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Amodiaquinehsa05144Malaria2.07E-024P60033, P01375, P35443, P26718CD81, TNF, THBS4, KLRK1More
Amodiaquinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Amodiaquinehsa05163Human cytomegalovirus infection1.72E-028P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Amodiaquinehsa05200Pathways in cancer9.46E-0317Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RBMore
Amodiaquinehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Amodiaquinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Amodiaquinehsa05212Pancreatic cancer3.94E-024P42338, P84022, Q13485, O75293PIK3CB, SMAD3, SMAD4, GADD45BMore
Amodiaquinehsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Amodiaquinehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Amodiaquinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Amodiaquinehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Amodiaquinehsa05418Fluid shear stress and atherosclerosis3.61E-026Q16539, P10599, P14780, P01375, P14778, P27930MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Amodiaquine (SDC: 4.51)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P21453S1PR1Sphingosine 1Nonephosphate receptor 1Predicted10.14340.38470.2211.0621
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)