PharmaCoNets of Amlodipine (SPCN: 7.77 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Amlodipinehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Amlodipinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Amlodipinehsa00220Arginine biosynthesis1.97E-022P15104, P49448GLUL, GLUD2More
Amlodipinehsa00250Alanine, aspartate and glutamate metabolism1.97E-022P49448, P15104GLUD2, GLULMore
Amlodipinehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Amlodipinehsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate4.32E-021Q9Y2C2USTMore
Amlodipinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Amlodipinehsa00604Glycosphingolipid biosynthesis - ganglio series1.34E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Amlodipinehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Amlodipinehsa00910Nitrogen metabolism1.97E-022P15104, P49448GLUL, GLUD2More
Amlodipinehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Amlodipinehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Amlodipinehsa03010Ribosome1.03E-022P46777, P50914RPL5, RPL14More
Amlodipinehsa04064NF-kappa B signaling pathway4.58E-034Q13489, Q13546, Q9UDY8, Q9UNE0BIRC3, RIPK1, MALT1, EDARMore
Amlodipinehsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Amlodipinehsa04150mTOR signaling pathway7.19E-033Q9NQL2, Q13322, Q93098RRAGD, GRB10, WNT8BMore
Amlodipinehsa04151PI3K-Akt signaling pathway3.96E-028P43657, P09603, Q9GZP0, P63218, P50151, P13612, O15335, Q13751P2RY5, CSF1, PDGFD, GNG5, GNG10, ITGA4, CHAD, LAMB3More
Amlodipinehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Amlodipinehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Amlodipinehsa04217Necroptosis2.93E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Amlodipinehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Amlodipinehsa04512ECM-receptor interaction4.41E-023Q13751, P13612, O15335LAMB3, ITGA4, CHADMore
Amlodipinehsa04610Complement and coagulation cascades1.12E-051P0C0L4C4AMore
Amlodipinehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Amlodipinehsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Amlodipinehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Amlodipinehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Amlodipinehsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Amlodipinehsa04724Glutamatergic synapse9.51E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Amlodipinehsa04727GABAergic synapse2.33E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Amlodipinehsa04730Long-term depression3.72E-022Q14344, P07948GNA13, LYNMore
Amlodipinehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Amlodipinehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Amlodipinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Amlodipinehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Amlodipinehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Amlodipinehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Amlodipinehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Amlodipinehsa05010Alzheimer disease4.39E-026O15399, Q9NZJ5, Q13564, Q71U36, P09603, P21796GRIN2D, EIF2AK3, APPBP1, TUBA1A, CSF1, VDAC1More
Amlodipinehsa05032Morphine addiction1.34E-024P63218, P50151, Q07343, P43250GNG5, GNG10, PDE4B, GRK6More
Amlodipinehsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Amlodipinehsa05133Pertussis4.20E-021P0C0L4C4AMore
Amlodipinehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Amlodipinehsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Amlodipinehsa05150Staphylococcus aureus infection4.36E-022P0C0L4, P13646C4A, KRT13More
Amlodipinehsa05214Glioma4.10E-022P09619, Q02750PDGFRB, MAP2K1More
Amlodipinehsa05218Melanoma1.34E-022P09619, Q02750PDGFRB, MAP2K1More
Amlodipinehsa05230Central carbon metabolism in cancer4.10E-022P09619, Q02750PDGFRB, MAP2K1More
Amlodipinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Levamlodipinehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Levamlodipinehsa00220Arginine biosynthesis1.97E-022P15104, P49448GLUL, GLUD2More
Levamlodipinehsa00250Alanine, aspartate and glutamate metabolism1.97E-022P49448, P15104GLUD2, GLULMore
Levamlodipinehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Levamlodipinehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Levamlodipinehsa00910Nitrogen metabolism1.97E-022P15104, P49448GLUL, GLUD2More
Levamlodipinehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Levamlodipinehsa04064NF-kappa B signaling pathway4.58E-034Q13489, Q13546, Q9UDY8, Q9UNE0BIRC3, RIPK1, MALT1, EDARMore
Levamlodipinehsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Levamlodipinehsa04151PI3K-Akt signaling pathway3.96E-028P43657, P09603, Q9GZP0, P63218, P50151, P13612, O15335, Q13751P2RY5, CSF1, PDGFD, GNG5, GNG10, ITGA4, CHAD, LAMB3More
Levamlodipinehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Levamlodipinehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Levamlodipinehsa04217Necroptosis2.93E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Levamlodipinehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Levamlodipinehsa04512ECM-receptor interaction4.41E-023Q13751, P13612, O15335LAMB3, ITGA4, CHADMore
Levamlodipinehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Levamlodipinehsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Levamlodipinehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Levamlodipinehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Levamlodipinehsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Levamlodipinehsa04724Glutamatergic synapse9.51E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Levamlodipinehsa04727GABAergic synapse2.33E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Levamlodipinehsa04730Long-term depression3.72E-022Q14344, P07948GNA13, LYNMore
Levamlodipinehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Levamlodipinehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Levamlodipinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Levamlodipinehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Levamlodipinehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Levamlodipinehsa05010Alzheimer disease4.39E-026O15399, Q9NZJ5, Q13564, Q71U36, P09603, P21796GRIN2D, EIF2AK3, APPBP1, TUBA1A, CSF1, VDAC1More
Levamlodipinehsa05032Morphine addiction1.34E-024P63218, P50151, Q07343, P43250GNG5, GNG10, PDE4B, GRK6More
Levamlodipinehsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore

Community members of Amlodipine (SDC: 2.84)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q8IZS8CACNA2D3VoltageNonedependent calcium channel subunit alphaNone2/deltaNone3Reported00.09430.040.32910.4562
P61088UBE2NUbiquitinNoneconjugating enzyme E2 NPredicted00.11020.38250.37361.1937
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P54284CACNB3VoltageNonedependent LNonetype calcium channel subunit betaNone3Predicted00.10260.15390.32910.6881
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)