PharmaCoNets of Amlexanox (SPCN: 3.70 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Amlexanoxhsa00030Pentose phosphate pathway4.66E-023P60891, P04075, P37837PRPS1, ALDOA, TALDO1More
Amlexanoxhsa00071Fatty acid degradation1.72E-024P11310, O75521, P11766, P33121ACADM, ECI2, ADH5, ACSL1More
Amlexanoxhsa00220Arginine biosynthesis4.33E-022P05089, P49448ARG1, GLUD2More
Amlexanoxhsa00500Starch and sucrose metabolism2.84E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Amlexanoxhsa00512Mucin type O-glycan biosynthesis2.11E-022O95395, Q8N4A0GCNT3, GALNT4More
Amlexanoxhsa00514Other types of O-glycan biosynthesis3.37E-022P15907, Q8N4A0ST6GAL1, GALNT4More
Amlexanoxhsa00564Glycerophospholipid metabolism3.93E-023P49619, O14494, Q3LIE5DGKG, PLPP1, ADPRMMore
Amlexanoxhsa00760Nicotinate and nicotinamide metabolism2.11E-022P43490, Q13423PBEF1, NNTMore
Amlexanoxhsa00910Nitrogen metabolism4.33E-022P22748, P49448CA4, GLUD2More
Amlexanoxhsa00970Aminoacyl-tRNA biosynthesis2.11E-022O95363, P54136FARS2, RARS1More
Amlexanoxhsa01200Carbon metabolism4.29E-024P04406, O14521, Q9P2R7, Q02252GAPDH, SDHD, SUCLA2, ALDH6A1More
Amlexanoxhsa03010Ribosome5.87E-0312P62753, P39019, P42677, P62906, P62917, Q07020, P61513, Q02878, P63173, P36578, P05386, P23396RPS6, RPS19, RPS27, RPL10A, RPL8, RPL18, RPL37A, RPL6, RPL38, RPL4, RPLP1, RPS3More
Amlexanoxhsa03013RNA transport5.07E-0414O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, P47813, Q14152, O75822, Q14240, Q9Y6A5, Q06787, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, EIF4A2, TACC3, FMR1, FXR1More
Amlexanoxhsa03040Spliceosome3.11E-027O14776, O75940, P09651, O75494, Q07955, O95777, O43395TCERG1, SMNDC1, HNRNPA1, FUSIP1, SFRS1, LSM8, PRPF3More
Amlexanoxhsa03060Protein export2.43E-022Q15070, O76094OXA1L, SRP72More
Amlexanoxhsa04060Cytokine-cytokine receptor interaction4.07E-0314P32927, P27930, P01584, P61073, P25024, P25025, Q9UBD3, P47992, P20333, P01375, P09341, Q99731, P18510, Q93038CSF2RB, IL1R2, IL1B, CXCR4, CXCR1, CXCR2, XCL2, XCL1, TNFRSF1B, TNF, CXCL1, CCL19, IL1RN, TNFRSF25More
Amlexanoxhsa04061Viral protein interaction with cytokine and cytokine receptor5.73E-0410Q99731, P09341, P25024, P25025, P61073, P47992, Q9UBD3, P09603, P20333, P01375CCL19, CXCL1, CXCR1, CXCR2, CXCR4, XCL1, XCL2, CSF1, TNFRSF1B, TNFMore
Amlexanoxhsa04062Chemokine signaling pathway1.88E-0310P25024, P25025, P09341, P47992, Q9UBD3, P07948, P63218, P50151, Q08881, P49841CXCR1, CXCR2, CXCL1, XCL1, XCL2, LYN, GNG5, GNG10, ITK, GSK3BMore
Amlexanoxhsa04064NF-kappa B signaling pathway1.52E-0210O00463, P01584, P01375, Q04759, Q16548, P06239, P63279, P24522, P09341, Q99731TRAF5, IL1B, TNF, PRKCQ, BCL2A1, LCK, UBE2I, GADD45A, CXCL1, CCL19More
Amlexanoxhsa04071Sphingolipid signaling pathway4.43E-026P01375, Q13362, Q16537, Q9BX95, Q16539, P10415TNF, PPP2R5C, PPP2R5E, SGPP1, MAPK14, BCL2More
Amlexanoxhsa04080Neuroactive ligand-receptor interaction1.61E-025P43657, Q01726, P21730, P14416, P35318P2RY5, MC1R, C5AR1, DRD2, ADMMore
Amlexanoxhsa04114Oocyte meiosis2.67E-027Q9UJX2, Q14643, P22694, Q16539, Q14683, Q13362, Q16537CDC23, ITPR1, PRKACB, MAPK14, SMC1A, PPP2R5C, PPP2R5EMore
Amlexanoxhsa04145Phagosome3.11E-022P01889, P10321HLA-B, HLA-CMore
Amlexanoxhsa04218Cellular senescence1.60E-022P01889, P10321HLA-B, HLA-CMore
Amlexanoxhsa04330Notch signaling pathway2.93E-023Q13547, Q92769, Q92830HDAC1, HDAC2, KAT2AMore
Amlexanoxhsa04390Hippo signaling pathway1.52E-024P63261, Q13485, O15105, O43623ACTG1, SMAD4, SMAD7, SNAI2More
Amlexanoxhsa04514Cell adhesion molecules2.20E-022P01889, P10321HLA-B, HLA-CMore
Amlexanoxhsa04520Adherens junction3.44E-023Q13485, O43623, P63261SMAD4, SNAI2, ACTG1More
Amlexanoxhsa04612Antigen processing and presentation2.01E-054P04233, P01889, P10321, Q06323CD74, HLA-B, HLA-C, PSME1More
Amlexanoxhsa04621NOD-like receptor signaling pathway3.24E-029Q16539, Q14643, P21796, P10599, P43490, O00463, P29728, P09341, P12838MAPK14, ITPR1, VDAC1, TXN, PBEF1, TRAF5, OAS2, CXCL1, DEFA4More
Amlexanoxhsa04640Hematopoietic cell lineage6.83E-039P13612, P14778, P27930, P15144, P11836, P07766, P09693, P01732, P09603ITGA4, IL1R1, IL1R2, ANPEP, MS4A1, CD3E, CD3G, CD8A, CSF1More
Amlexanoxhsa04650Natural killer cell mediated cytotoxicity1.85E-0513P01375, P78314, P06239, O60880, P20963, Q29983, P10321, P01889, Q13241, P26718, O75015, P26717, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, MICA, HLA-C, HLA-B, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Amlexanoxhsa04658Th1 and Th2 cell differentiation1.59E-0412Q04759, P07766, P20963, P09693, Q16539, P06239, Q14765, P23771, Q9UL17, P46531, Q9UM47, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, LCK, STAT4, GATA3, TBX21, NOTCH1, NOTCH3, RUNX3More
Amlexanoxhsa04659Th17 cell differentiation3.32E-027Q04759, Q16539, P14778, Q9UL17, P07766, P09693, P20963PRKCQ, MAPK14, IL1R1, TBX21, CD3E, CD3G, CD247More
Amlexanoxhsa04660T cell receptor signaling pathway1.05E-0413P01375, Q04759, O95267, Q08881, Q9NQU5, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, PRKCQ, RASGRP1, ITK, PAK6, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Amlexanoxhsa04662B cell receptor signaling pathway2.61E-024P49841, P60033, P07948, Q8N149GSK3B, CD81, LYN, LILRA2More
Amlexanoxhsa04664Fc epsilon RI signaling pathway4.19E-023Q16539, P07948, P09917MAPK14, LYN, ALOX5More
Amlexanoxhsa04668TNF signaling pathway2.69E-028P01375, O00463, P18848, P09341, P01584, P20749, P14780, P20333TNF, TRAF5, ATF4, CXCL1, IL1B, BCL3, MMP9, TNFRSF1BMore
Amlexanoxhsa04724Glutamatergic synapse1.11E-024P43003, P63218, P50151, P15104SLC1A3, GNG5, GNG10, GLULMore
Amlexanoxhsa04728Dopaminergic synapse2.96E-025P14416, P63218, P50151, P49841, Q16539DRD2, GNG5, GNG10, GSK3B, MAPK14More
Amlexanoxhsa04940Type I diabetes mellitus4.45E-032P01889, P10321HLA-B, HLA-CMore
Amlexanoxhsa04964Proximal tubule bicarbonate reclamation4.33E-022P22748, P49448CA4, GLUD2More
Amlexanoxhsa05014Amyotrophic lateral sclerosis3.44E-0213P01375, P10415, Q16539, Q16718, O14521, Q9NZJ5, Q13561, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629TNF, BCL2, MAPK14, NDUFA5, SDHD, EIF2AK3, DCTN2, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7More
Amlexanoxhsa05120Epithelial cell signaling in Helicobacter pylori infection2.85E-045Q16539, P09341, P25024, P25025, P07948MAPK14, CXCL1, CXCR1, CXCR2, LYNMore
Amlexanoxhsa05143African trypanosomiasis3.23E-022P69905, P68871HBA2, HBBMore
Amlexanoxhsa05144Malaria2.29E-025P60033, P01375, P35443, P01584, P26718CD81, TNF, THBS4, IL1B, KLRK1More
Amlexanoxhsa05146Amoebiasis2.69E-028P01584, P09341, P27930, P01375, P05089, P22694, P12814, P08311IL1B, CXCL1, IL1R2, TNF, ARG1, PRKACB, ACTN1, CTSGMore
Amlexanoxhsa05163Human cytomegalovirus infection1.18E-0310P63218, P50151, Q14643, Q14344, P49841, P14778, P25025, Q16539, O00463, P30101GNG5, GNG10, ITPR1, GNA13, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5, PDIA3More
Amlexanoxhsa05165Human papillomavirus infection5.90E-033P01889, P10321, O14745HLA-B, HLA-C, SLC9A3R1More
Amlexanoxhsa05167Kaposi sarcoma-associated herpesvirus infection2.25E-0311P01889, P10321, P49841, P63218, P50151, P09341, Q14643, O15123, P07948, Q29983, Q16539HLA-B, HLA-C, GSK3B, GNG5, GNG10, CXCL1, ITPR1, ANGPT2, LYN, MICA, MAPK14More
Amlexanoxhsa05168Herpes simplex virus 1 infection6.41E-033P04233, P01889, P10321CD74, HLA-B, HLA-CMore
Amlexanoxhsa05169Epstein-Barr virus infection1.03E-0415Q13547, Q92769, O00463, Q16539, P07948, P01889, P10321, P30101, Q13761, P24522, P30279, P29728, P07766, P09693, P20963HDAC1, HDAC2, TRAF5, MAPK14, LYN, HLA-B, HLA-C, PDIA3, RUNX3, GADD45A, CCND2, OAS2, CD3E, CD3G, CD247More
Amlexanoxhsa05170Human immunodeficiency virus 1 infection2.87E-022P01889, P10321HLA-B, HLA-CMore
Amlexanoxhsa05171Coronavirus disease - COVID-192.56E-0215P01375, P01584, P23396, P62753, P39019, P42677, P62906, P36578, Q02878, P62917, Q07020, P61513, P63173, P05386, P21730TNF, IL1B, RPS3, RPS6, RPS19, RPS27, RPL10A, RPL4, RPL6, RPL8, RPL18, RPL37A, RPL38, RPLP1, C5AR1More
Amlexanoxhsa05202Transcriptional misregulation in cancer4.88E-028P01106, P35226, O60583, P04141, P59665, P59666, P42773, O75293MYC, BMI1, CCNT2, CSF2, DEFA1; DEFA1B, DEFA3, CDKN2C, GADD45BMore
Amlexanoxhsa05203Viral carcinogenesis1.99E-022P01889, P10321HLA-B, HLA-CMore
Amlexanoxhsa05206MicroRNAs in cancer3.11E-026P01106, P26358, Q9UM47, P35226, Q96EB6, P19174MYC, DNMT1, NOTCH3, BMI1, SIRT1, PLCG1More
Amlexanoxhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.65E-026O95267, P07766, P20963, P09693, Q04759, Q16539RASGRP1, CD3E, CD247, CD3G, PRKCQ, MAPK14More
Amlexanoxhsa05320Autoimmune thyroid disease3.49E-032P01889, P10321HLA-B, HLA-CMore
Amlexanoxhsa05321Inflammatory bowel disease3.10E-025P01375, Q14765, Q9UL17, P23771, P01584TNF, STAT4, TBX21, GATA3, IL1BMore
Amlexanoxhsa05330Allograft rejection3.49E-032P01889, P10321HLA-B, HLA-CMore
Amlexanoxhsa05332Graft-versus-host disease4.45E-032P01889, P10321HLA-B, HLA-CMore
Amlexanoxhsa05412Arrhythmogenic right ventricular cardiomyopathy4.29E-024P23229, P16144, P60709, P35609ITGA6, ITGB4, ACTB, ACTN2More
Amlexanoxhsa05416Viral myocarditis5.53E-032P01889, P10321HLA-B, HLA-CMore

Community members of Amlexanox (SDC: 0.39)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P80511S100A12Protein S100NoneA12Reported10.47670.030900.3002
P41440SLC19A1Reduced folate transporterPredicted00.14250.0380.09850.2457
P06702S100A9Protein S100NoneA9Predicted10.04390.02560.12470.1978
P25815S100PProtein S100NonePPredicted00.48450.029400.301
P31949S100A11Protein S100NoneA11Predicted00.08730.018600.0808
P05109S100A8Protein S100NoneA8Predicted10.26720.02330.12470.305
P60903S100A10Protein S100NoneA10Predicted00.25010.02120.23330.4008
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)