PharmaCoNets of Amisulpride (SPCN: 27.66 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Amisulpridehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Amisulpridehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Amisulpridehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Amisulpridehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Amisulpridehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Amisulpridehsa00983Drug metabolism - other enzymes3.50E-023P04183, P32320, P05164TK1, CDA, MPOMore
Amisulpridehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Amisulpridehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Amisulpridehsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Amisulpridehsa03010Ribosome1.98E-1216P62753, P42677, P32969, P40429, P46776, Q9H0U6, P46778, P62945, P62910, P61927, P61513, Q02878, P36578, P05386, P62249, P23396RPS6, RPS27, RPL9, RPL13A, RPL27A, MRPL18, RPL21, RPL41, RPL32, RPL37, RPL37A, RPL6, RPL4, RPLP1, RPS16, RPS3More
Amisulpridehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Amisulpridehsa03410Base excision repair2.21E-022P49005, P29372POLD2, MPGMore
Amisulpridehsa04064NF-kappa B signaling pathway1.60E-028P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1More
Amisulpridehsa04071Sphingolipid signaling pathway1.17E-036P21453, Q9H228, P01375, Q13362, Q9BX95, P10415S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Amisulpridehsa04080Neuroactive ligand-receptor interaction2.16E-039P08311, P28472, Q15722, P21453, Q9H228, O00398, P21730, Q16581, P07550CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1, ADRB2More
Amisulpridehsa04115p53 signaling pathway3.98E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Amisulpridehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Amisulpridehsa04210Apoptosis3.77E-028Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1More
Amisulpridehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Amisulpridehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Amisulpridehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Amisulpridehsa04612Antigen processing and presentation2.09E-048P13765, P48382, Q14953, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Amisulpridehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Amisulpridehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Amisulpridehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Amisulpridehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Amisulpridehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Amisulpridehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Amisulpridehsa04725Cholinergic synapse4.83E-024P22694, Q14643, P18848, P10415PRKACB, ITPR1, ATF4, BCL2More
Amisulpridehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Amisulpridehsa04742Taste transduction1.01E-021P30939HTR1FMore
Amisulpridehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Amisulpridehsa04915Estrogen signaling pathway2.96E-025P14780, P22694, P18848, Q14643, P10415MMP9, PRKACB, ATF4, ITPR1, BCL2More
Amisulpridehsa04918Thyroid hormone synthesis3.50E-023P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Amisulpridehsa04920Adipocytokine signaling pathway4.36E-022Q15831, P20333STK11, TNFRSF1BMore
Amisulpridehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Amisulpridehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Amisulpridehsa04927Cortisol synthesis and secretion4.44E-043Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Amisulpridehsa04928Parathyroid hormone synthesis, secretion and action2.13E-025Q14643, P22694, P23771, P18848, P10415ITPR1, PRKACB, GATA3, ATF4, BCL2More
Amisulpridehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Amisulpridehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Amisulpridehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Amisulpridehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Amisulpridehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Amisulpridehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Amisulpridehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Amisulpridehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Amisulpridehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Amisulpridehsa05133Pertussis4.20E-021P0C0L4C4AMore
Amisulpridehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Amisulpridehsa05144Malaria1.44E-035P69905, P68871, P01375, P35443, P26718HBA2, HBB, TNF, THBS4, KLRK1More
Amisulpridehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Amisulpridehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Amisulpridehsa05171Coronavirus disease - COVID-193.70E-1015P23396, P62753, P62249, P42677, P40429, P36578, Q02878, P32969, P46778, P46776, P62910, P61927, P61513, P62945, P05386RPS3, RPS6, RPS16, RPS27, RPL13A, RPL4, RPL6, RPL9, RPL21, RPL27A, RPL32, RPL37, RPL37A, RPL41, RPLP1More
Amisulpridehsa05202Transcriptional misregulation in cancer1.77E-0211Q15532, Q13315, P14780, Q15744, Q16548, O15550, P05164, P12838, P08246, Q9C0K0, P24522SS18, ATM, MMP9, CEBPE, BCL2A1, UTX, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Amisulpridehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Amisulpridehsa05321Inflammatory bowel disease1.19E-036P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Amisulpridehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Amisulpridehsa05332Graft-versus-host disease1.91E-056P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Amisulpridehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Amisulpridehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Amisulpride (SDC: 3.95)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P42677RPS2740S ribosomal protein S27Predicted00.37810.02160.4320.6644
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
DRD2P14416IC501.5
DRD2P14416IC503
DRD2P14416IC508.5
DRD2P14416Ki1.3
DRD2P14416Ki3
DRD2P14416Ki13