PharmaCoNets of Amiodarone (SPCN: 22.24 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Amiodaronehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Amiodaronehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Amiodaronehsa00053Ascorbate and aldarate metabolism5.61E-032P51648, Q9UEF7ALDH3A2, KLMore
Amiodaronehsa00220Arginine biosynthesis1.97E-022P15104, P49448GLUL, GLUD2More
Amiodaronehsa00250Alanine, aspartate and glutamate metabolism1.97E-022P49448, P15104GLUD2, GLULMore
Amiodaronehsa00280Valine, leucine and isoleucine degradation4.55E-022P21953, P51648BCKDHB, ALDH3A2More
Amiodaronehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Amiodaronehsa00604Glycosphingolipid biosynthesis - ganglio series1.34E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Amiodaronehsa00630Glyoxylate and dicarboxylate metabolism4.29E-032P40925, P15104MDH1, GLULMore
Amiodaronehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Amiodaronehsa00910Nitrogen metabolism1.97E-022P15104, P49448GLUL, GLUD2More
Amiodaronehsa00970Aminoacyl-tRNA biosynthesis1.09E-022O95363, Q15046FARS2, KARSMore
Amiodaronehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Amiodaronehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Amiodaronehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Amiodaronehsa01524Platinum drug resistance1.79E-022O15392, P11388BIRC5, TOP2AMore
Amiodaronehsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Amiodaronehsa03040Spliceosome6.28E-036Q14562, O43143, O60508, Q07955, Q01130, Q13243DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5More
Amiodaronehsa03410Base excision repair7.59E-031P27695APEX1More
Amiodaronehsa04024cAMP signaling pathway4.38E-024P42338, P0DP23, Q13370, Q13009PIK3CB, CALM1, PDE3B, TIAM1More
Amiodaronehsa04070Phosphatidylinositol signaling system4.86E-023P0DP23, P42338, P27987CALM1, PIK3CB, ITPKBMore
Amiodaronehsa04071Sphingolipid signaling pathway6.08E-045P21453, Q9H228, P01375, Q13362, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, GAB2More
Amiodaronehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Amiodaronehsa04141Protein processing in endoplasmic reticulum9.57E-034P30101, P49257, P60604, Q9H173PDIA3, LMAN1, UBE2G2, SIL1More
Amiodaronehsa04151PI3K-Akt signaling pathway3.96E-028P43657, P09603, Q9GZP0, P63218, P50151, P13612, O15335, Q13751P2RY5, CSF1, PDGFD, GNG5, GNG10, ITGA4, CHAD, LAMB3More
Amiodaronehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Amiodaronehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Amiodaronehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Amiodaronehsa04360Axon guidance1.71E-024P20827, O95631, P42338, P23528EFNA1, NTN1, PIK3CB, CFL1More
Amiodaronehsa04512ECM-receptor interaction4.41E-023Q13751, P13612, O15335LAMB3, ITGA4, CHADMore
Amiodaronehsa04610Complement and coagulation cascades4.69E-031P0C0L4C4AMore
Amiodaronehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Amiodaronehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Amiodaronehsa04657IL-17 signaling pathway2.10E-035P49841, P19875, P14780, P80188, P01375GSK3B, CXCL2, MMP9, LCN2, TNFMore
Amiodaronehsa04659Th17 cell differentiation4.38E-024P42224, P14784, P40189, P08238STAT1, IL2RB, IL6ST, HSP90AB1More
Amiodaronehsa04666Fc gamma R-mediated phagocytosis3.08E-023P42338, P23528, P14598PIK3CB, CFL1, NCF1More
Amiodaronehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Amiodaronehsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Amiodaronehsa04724Glutamatergic synapse9.51E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Amiodaronehsa04727GABAergic synapse2.44E-033P63218, P50151, P15104GNG5, GNG10, GLULMore
Amiodaronehsa04730Long-term depression3.72E-022Q14344, P07948GNA13, LYNMore
Amiodaronehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Amiodaronehsa04742Taste transduction1.01E-021P30939HTR1FMore
Amiodaronehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Amiodaronehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Amiodaronehsa04914Progesterone-mediated oocyte maturation3.92E-023P42338, Q13370, P08238PIK3CB, PDE3B, HSP90AB1More
Amiodaronehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Amiodaronehsa04920Adipocytokine signaling pathway4.31E-022Q9Y478, Q96RR4PRKAB1, CAMKK2More
Amiodaronehsa04924Renin secretion2.98E-034P22694, P07550, Q13370, P0DP23PRKACB, ADRB2, PDE3B, CALM1More
Amiodaronehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Amiodaronehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Amiodaronehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Amiodaronehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Amiodaronehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Amiodaronehsa05010Alzheimer disease4.39E-026O15399, Q9NZJ5, Q13564, Q71U36, P09603, P21796GRIN2D, EIF2AK3, APPBP1, TUBA1A, CSF1, VDAC1More
Amiodaronehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Amiodaronehsa05032Morphine addiction1.34E-024P63218, P50151, Q07343, P43250GNG5, GNG10, PDE4B, GRK6More
Amiodaronehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Amiodaronehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Amiodaronehsa05150Staphylococcus aureus infection4.36E-022P0C0L4, P13646C4A, KRT13More
Amiodaronehsa05168Herpes simplex virus 1 infection1.15E-028P42224, Q07955, Q01130, Q13243, P42338, Q13398, Q03923, Q9UDV6STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF211, ZNF85, ZNF212More
Amiodaronehsa05200Pathways in cancer3.92E-029P42338, P08238, P42224, P43246, P14923, O75293, P0DP23, P14784, P40189PIK3CB, HSP90AB1, STAT1, MSH2, JUP, GADD45B, CALM1, IL2RB, IL6STMore
Amiodaronehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Amiodaronehsa05212Pancreatic cancer1.72E-023P42338, P42224, O75293PIK3CB, STAT1, GADD45BMore
Amiodaronehsa05214Glioma1.52E-035P09619, P0DP23, Q02750, P42338, O75293PDGFRB, CALM1, MAP2K1, PIK3CB, GADD45BMore
Amiodaronehsa05218Melanoma1.34E-022P09619, Q02750PDGFRB, MAP2K1More
Amiodaronehsa05230Central carbon metabolism in cancer4.10E-022P09619, Q02750PDGFRB, MAP2K1More
Amiodaronehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Amiodaronehsa05332Graft-versus-host disease8.79E-033P01375, P26715, Q13241TNF, KLRC1, KLRD1More
Amiodaronehsa05418Fluid shear stress and atherosclerosis3.73E-024P42338, P14598, P0DP23, P08238PIK3CB, NCF1, CALM1, HSP90AB1More

Community members of Amiodarone (SDC: 2.95)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P07550ADRB2BetaNone2 adrenergic receptorReported00.007110.22052.224
P54284CACNB3VoltageNonedependent LNonetype calcium channel subunit betaNone3Reported00.10260.15390.32910.6881
P61088UBE2NUbiquitinNoneconjugating enzyme E2 NPredicted00.11020.38250.37361.1937
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P27695APEX1DNANone(apurinic or apyrimidinic site) endonucleasePredicted10.4020.2210.12170.7647
O95259KCNH1Potassium voltageNonegated channel subfamily H member 1Predicted00.04250.046500.1143
P10826RARBRetinoic acid receptor betaPredicted00.00940.34660.30050.9983
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)