PharmaCoNets of Aminophylline (SPCN: 26.25 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Aminophyllinehsa00030Pentose phosphate pathway1.08E-053P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Aminophyllinehsa00190Oxidative phosphorylation1.07E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Aminophyllinehsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Aminophyllinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Aminophyllinehsa01230Biosynthesis of amino acids2.22E-034P51854, P60891, Q99707, P37837TKTL1, PRPS1, MTR, TALDO1More
Aminophyllinehsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Aminophyllinehsa03013RNA transport2.35E-0510O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3More
Aminophyllinehsa03040Spliceosome2.09E-027Q14562, O43143, O75940, O75494, Q07955, Q01130, Q13243DHX8, DHX15, SMNDC1, FUSIP1, SFRS1, SFRS2, SFRS5More
Aminophyllinehsa04014Ras signaling pathway1.70E-027P20827, Q9NRA1, P49767, P17252, P0DP23, P62873, P19174EFNA1, PDGFC, VEGFC, PRKCA, CALM1, GNB1, PLCG1More
Aminophyllinehsa04015Rap1 signaling pathway4.58E-026P20827, Q9NRA1, P49767, P0DP23, P17252, P19174EFNA1, PDGFC, VEGFC, CALM1, PRKCA, PLCG1More
Aminophyllinehsa04020Calcium signaling pathway2.01E-026P17252, P19174, P0DP23, P20020, Q9NRA1, P49767PRKCA, PLCG1, CALM1, ATP2B1, PDGFC, VEGFCMore
Aminophyllinehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Aminophyllinehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Aminophyllinehsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Aminophyllinehsa04070Phosphatidylinositol signaling system4.40E-024P19174, P0DP23, P23743, P17252PLCG1, CALM1, DGKA, PRKCAMore
Aminophyllinehsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Aminophyllinehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Aminophyllinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Aminophyllinehsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Aminophyllinehsa04145Phagosome4.68E-025Q15080, P14598, Q13509, P68371, Q13488NCF4, NCF1, TUBB3, TUBB2C, TCIRG1More
Aminophyllinehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Aminophyllinehsa04217Necroptosis1.36E-027P01568, P42224, P08238, Q6FI13, Q93077, O43633, Q08752IFNA21, STAT1, HSP90AB1, H2AC18; H2AC19, HIST1H2AC, CHMP2A, PPIDMore
Aminophyllinehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Aminophyllinehsa04360Axon guidance2.29E-025P16333, P20827, O95631, P17252, P19174NCK1, EFNA1, NTN1, PRKCA, PLCG1More
Aminophyllinehsa04540Gap junction1.67E-024P17252, Q13509, P68371, Q9NRA1PRKCA, TUBB3, TUBB2C, PDGFCMore
Aminophyllinehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Aminophyllinehsa04623Cytosolic DNA-sensing pathway3.29E-022P01568, P25963IFNA21, NFKBIAMore
Aminophyllinehsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Aminophyllinehsa04650Natural killer cell mediated cytotoxicity5.49E-0612P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, Q14953, P26715PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KIR2DS5, KLRC1More
Aminophyllinehsa04657IL-17 signaling pathway2.05E-039P25963, P08238, Q07955, P19875, P14780, P04141, P80188, P01375, P06702NFKBIA, HSP90AB1, SFRS1, CXCL2, MMP9, CSF2, LCN2, TNF, S100A9More
Aminophyllinehsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Aminophyllinehsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Aminophyllinehsa04660T cell receptor signaling pathway4.48E-0413P04141, P25963, Q04759, P42338, P10747, P19174, P16333, P07766, P20963, P01732, Q13191, P06239, P29350CSF2, NFKBIA, PRKCQ, PIK3CB, CD28, PLCG1, NCK1, CD3E, CD247, CD8A, CBLB, LCK, PTPN6More
Aminophyllinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Aminophyllinehsa04713Circadian entrainment3.32E-024P0DP23, P17252, P62873, O15055CALM1, PRKCA, GNB1, PER2More
Aminophyllinehsa04744Phototransduction1.18E-022P62873, P0DP23GNB1, CALM1More
Aminophyllinehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Aminophyllinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Aminophyllinehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Aminophyllinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Aminophyllinehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Aminophyllinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Aminophyllinehsa04933AGE-RAGE signaling pathway in diabetic complications1.72E-025P42224, Q12778, P49767, P17252, P19174STAT1, FOXO1, VEGFC, PRKCA, PLCG1More
Aminophyllinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Aminophyllinehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Aminophyllinehsa05012Parkinson disease3.12E-026Q16718, O14521, P19174, P0DP23, Q13509, P68371NDUFA5, SDHD, PLCG1, CALM1, TUBB3, TUBB2CMore
Aminophyllinehsa05022Pathways of neurodegeneration - multiple diseases2.29E-029Q13509, P68371, Q16718, O14521, Q13561, P19174, P17252, Q08752, P0DP23TUBB3, TUBB2C, NDUFA5, SDHD, DCTN2, PLCG1, PRKCA, PPID, CALM1More
Aminophyllinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Aminophyllinehsa05110Vibrio cholerae infection1.98E-023Q13488, P17252, P19174TCIRG1, PRKCA, PLCG1More
Aminophyllinehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Aminophyllinehsa05132Salmonella infection1.70E-028P25963, P08238, P04406, O75369, Q13561, Q13509, P68371, P49754NFKBIA, HSP90AB1, GAPDH, FLNB, DCTN2, TUBB3, TUBB2C, VPS41More
Aminophyllinehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Aminophyllinehsa05140Leishmaniasis1.72E-025P14598, P42224, P25963, P29350, Q15080NCF1, STAT1, NFKBIA, PTPN6, NCF4More
Aminophyllinehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Aminophyllinehsa05146Amoebiasis2.05E-0511P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, P22694, P12814CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1More
Aminophyllinehsa05167Kaposi sarcoma-associated herpesvirus infection5.71E-038P01568, P42224, P25963, P40189, P62873, P19174, P04141, P0DP23IFNA21, STAT1, NFKBIA, IL6ST, GNB1, PLCG1, CSF2, CALM1More
Aminophyllinehsa05168Herpes simplex virus 1 infection4.15E-0312P25963, P01568, Q9GZY0, P42224, Q07955, Q01130, Q13243, Q13398, Q03923, P52738, O75820, Q9UDV6NFKBIA, IFNA21, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, ZNF211, ZNF85, ZNF140, ZNF189, ZNF212More
Aminophyllinehsa05171Coronavirus disease - COVID-191.36E-027P25963, P42224, P01568, P40189, P04141, P19174, P17252NFKBIA, STAT1, IFNA21, IL6ST, CSF2, PLCG1, PRKCAMore
Aminophyllinehsa05200Pathways in cancer1.75E-0214P08238, P42224, P25963, P19174, P17252, P43246, P14923, P49767, Q12778, P62873, O75293, P0DP23, P01568, P40189HSP90AB1, STAT1, NFKBIA, PLCG1, PRKCA, MSH2, JUP, VEGFC, FOXO1, GNB1, GADD45B, CALM1, IFNA21, IL6STMore
Aminophyllinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Aminophyllinehsa05214Glioma1.09E-024P0DP23, P17252, P19174, O75293CALM1, PRKCA, PLCG1, GADD45BMore
Aminophyllinehsa05231Choline metabolism in cancer2.25E-035Q9NRA1, Q9Y259, P19174, P23743, P17252PDGFC, CHKB, PLCG1, DGKA, PRKCAMore
Aminophyllinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer7.13E-0410P25963, P42338, P19174, P07766, P20963, P06239, P29350, P42224, P10747, Q04759NFKBIA, PIK3CB, PLCG1, CD3E, CD247, LCK, PTPN6, STAT1, CD28, PRKCQMore
Aminophyllinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Aminophyllinehsa05332Graft-versus-host disease8.79E-033P01375, P26715, Q13241TNF, KLRC1, KLRD1More
Aminophyllinehsa05415Diabetic cardiomyopathy1.20E-026P17252, P14598, Q15080, Q16718, O14521, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDHMore

Community members of Aminophylline (SDC: 2.66)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q92769HDAC2Histone deacetylase 2Reported10.047310.9863.0097
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q13370PDE3BcGMPNoneinhibited 3',5'Nonecyclic phosphodiesterase BPredicted00.09060.16140.35580.7239
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)