PharmaCoNets

PharmaCoNets of Aminocaproic-acid (S_PCN: 41.51 )

Aminocaproic-acid regulated-network (S_DN: 13.61)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Aminocaproic-acid

hsa00030

Pentose phosphate pathway

5.07E-03

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Aminocaproic-acid

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Aminocaproic-acid

hsa00220

Arginine biosynthesis

1.54E-02

P05089, P49448

ARG1, GLUD2

Aminocaproic-acid

hsa00500

Starch and sucrose metabolism

1.92E-05

O43451, P46976, P06737

MGAM, GYG1, PYGL

Aminocaproic-acid

hsa00520

Amino sugar and nucleotide sugar metabolism

2.24E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Aminocaproic-acid

hsa00604

Glycosphingolipid biosynthesis - ganglio series

1.34E-02

P06865, Q9H4F1

HEXA, ST6GALNAC4

Aminocaproic-acid

hsa00630

Glyoxylate and dicarboxylate metabolism

1.29E-02

P40925, P15104

MDH1, GLUL

Aminocaproic-acid

hsa00730

Thiamine metabolism

1.44E-03

P05186, P24666

ALPL, ACP1

Aminocaproic-acid

hsa00790

Folate biosynthesis

4.05E-02

Q92820, P42330

GGH, AKR1C3

Aminocaproic-acid

hsa00910

Nitrogen metabolism

2.93E-02

P22748, P49448

CA4, GLUD2

Aminocaproic-acid

hsa00970

Aminoacyl-tRNA biosynthesis

5.32E-03

O95363, P54136, Q15046

FARS2, RARS1, KARS

Aminocaproic-acid

hsa00983

Drug metabolism - other enzymes

6.73E-05

P04183, P32320, P05164

TK1, CDA, MPO

Aminocaproic-acid

hsa01240

Biosynthesis of cofactors

2.52E-02

Q9BQB6, P14550

VKORC1, AKR1A1

Aminocaproic-acid

hsa03008

Ribosome biogenesis in eukaryotes

4.94E-02

P19784, P67870

CSNK2A2, CSNK2B

Aminocaproic-acid

hsa03013

RNA transport

4.09E-02

P52298, Q09161, O14893, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5

NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3

Aminocaproic-acid

hsa03410

Base excision repair

2.52E-02

P49005, P29372

POLD2, MPG

Aminocaproic-acid

hsa04024

cAMP signaling pathway

3.37E-02

P63092, P26678, P61586

GNAS, PLN, RHOA

Aminocaproic-acid

hsa04060

Cytokine-cytokine receptor interaction

1.74E-04

P14784, P27930, P14778, P08476, P26842, Q06643, Q13651, Q9HBE5, P25024, Q9UBD3, P47992, P01375, P09341, P19875, P18510, P01730, Q93038

IL2RB, IL1R2, IL1R1, INHBA, CD27, LTB, IL10RA, IL21R, CXCR1, XCL2, XCL1, TNF, CXCL1, CXCL2, IL1RN, CD4, TNFRSF25

Aminocaproic-acid

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.72E-05

P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375

CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNF

Aminocaproic-acid

hsa04062

Chemokine signaling pathway

3.27E-04

P25024, P25025, P09341, P19875, P07948, P42338, P19174, P63218, P50151, P43250

CXCR1, CXCR2, CXCL1, CXCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6

Aminocaproic-acid

hsa04064

NF-kappa B signaling pathway

3.15E-10

P10415, Q13489, P25963, P51617, O00463, P14778, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q13315, P24522, O75293, P09341, P19875, Q06643

BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, ATM, GADD45A, GADD45B, CXCL1, CXCL2, LTB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24158	PRTN3	Myeloblastin	P10415	BCL2	Apoptosis regulator Bcl-2	-0.787
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P24158	PRTN3	Myeloblastin	O00463	TRAF5	TNF receptor-associated factor 5	-0.8
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P08311	CTSG	Cathepsin G	O00463	TRAF5	TNF receptor-associated factor 5	-0.853
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P51124	GZMM	Granzyme M	P14778	IL1R1	Interleukin-1 receptor type 1	-0.886
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P24158	PRTN3	Myeloblastin	Q04759	PRKCQ	Protein kinase C theta type	-0.845
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P24158	PRTN3	Myeloblastin	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.733
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P24158	PRTN3	Myeloblastin	Q16548	BCL2A1	Bcl-2-related protein A1	0.802
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P08311	CTSG	Cathepsin G	Q16548	BCL2A1	Bcl-2-related protein A1	0.79
P51124	GZMM	Granzyme M	P07948	LYN	Tyrosine-protein kinase Lyn	-0.76
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08311	CTSG	Cathepsin G	Q13315	ATM	Serine-protein kinase ATM	-0.709
P24158	PRTN3	Myeloblastin	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.772
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P08311	CTSG	Cathepsin G	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.799
P51124	GZMM	Granzyme M	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.78
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P24158	PRTN3	Myeloblastin	P09341	CXCL1	Growth-regulated alpha protein	0.751
P51124	GZMM	Granzyme M	P09341	CXCL1	Growth-regulated alpha protein	-0.733
P08311	CTSG	Cathepsin G	P09341	CXCL1	Growth-regulated alpha protein	0.877
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P51124	GZMM	Granzyme M	P19875	CXCL2	C-X-C motif chemokine 2	-0.739
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P51124	GZMM	Granzyme M	Q06643	LTB	Lymphotoxin-beta	0.811

Aminocaproic-acid

hsa04071

Sphingolipid signaling pathway

2.67E-05

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2, Q02156

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2, PRKCE

Aminocaproic-acid

hsa04072

Phospholipase D signaling pathway

5.37E-03

P42338, P61586, P43657, P25024, P25025, P19174, O14986, P63092

PIK3CB, RHOA, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, GNAS

Aminocaproic-acid

hsa04080

Neuroactive ligand-receptor interaction

1.83E-04

P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581

CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1

Aminocaproic-acid

hsa04115

p53 signaling pathway

3.57E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Aminocaproic-acid

hsa04137

Mitophagy - animal

2.52E-02

P19784, P67870

CSNK2A2, CSNK2B

Aminocaproic-acid

hsa04145

Phagosome

1.53E-03

Q15080, P14598, Q13509, Q13488, P05164, P78380, O60603, P35443, P13765

NCF4, NCF1, TUBB3, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOB

Aminocaproic-acid

hsa04210

Apoptosis

1.09E-03

Q13315, P10415, Q13489, O76075, P25963, P01375, P24522, Q16548, Q13077, P43234, P18848, Q14643

ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, CTSO, ATF4, ITPR1

Aminocaproic-acid

hsa04213

Longevity regulating pathway - multiple species

3.66E-03

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Aminocaproic-acid

hsa04270

Vascular smooth muscle contraction

4.59E-02

Q02156

PRKCE

Aminocaproic-acid

hsa04310

Wnt signaling pathway

4.17E-03

P61586, P19784, P67870

RHOA, CSNK2A2, CSNK2B

Aminocaproic-acid

hsa04340

Hedgehog signaling pathway

1.88E-03

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Aminocaproic-acid

hsa04380

Osteoclast differentiation

1.02E-02

Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149

GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2

Aminocaproic-acid

hsa04510

Focal adhesion

4.07E-02

O14986, P61586, Q16363

PIP5K1B, RHOA, LAMA4

Aminocaproic-acid

hsa04520

Adherens junction

1.38E-04

P19784, P67870, P61586

CSNK2A2, CSNK2B, RHOA

Aminocaproic-acid

hsa04610

Complement and coagulation cascades

8.87E-08

P00734, P0C0L4

F2, C4A

Aminocaproic-acid

hsa04612

Antigen processing and presentation

1.41E-07

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24158	PRTN3	Myeloblastin	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.796
P49863	GZMK	Granzyme K	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.882
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P20160	AZU1	Azurocidin	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.79
P24158	PRTN3	Myeloblastin	P48382	RFX5	DNA-binding protein RFX5	-0.87
P49863	GZMK	Granzyme K	P48382	RFX5	DNA-binding protein RFX5	0.796
P08311	CTSG	Cathepsin G	P48382	RFX5	DNA-binding protein RFX5	-0.794
P20160	AZU1	Azurocidin	P48382	RFX5	DNA-binding protein RFX5	-0.753
P24158	PRTN3	Myeloblastin	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
P49863	GZMK	Granzyme K	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.891
P08311	CTSG	Cathepsin G	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P20160	AZU1	Azurocidin	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.765
P24158	PRTN3	Myeloblastin	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.77
P49863	GZMK	Granzyme K	P26717	KLRC2	NKG2-C type II integral membrane protein	0.891
P08311	CTSG	Cathepsin G	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
P20160	AZU1	Azurocidin	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.765
P24158	PRTN3	Myeloblastin	Q13241	KLRD1	Natural killer cells antigen CD94	-0.732
P49863	GZMK	Granzyme K	Q13241	KLRD1	Natural killer cells antigen CD94	0.809
P08311	CTSG	Cathepsin G	Q13241	KLRD1	Natural killer cells antigen CD94	-0.812
P20160	AZU1	Azurocidin	Q13241	KLRD1	Natural killer cells antigen CD94	-0.744
P49863	GZMK	Granzyme K	O43908	KLRC4	NKG2-F type II integral membrane protein	0.702
P24158	PRTN3	Myeloblastin	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.767
P49863	GZMK	Granzyme K	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.784
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
P20160	AZU1	Azurocidin	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.758
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P49863	GZMK	Granzyme K	P01375	TNF	Tumor necrosis factor	-0.8
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733

Aminocaproic-acid

hsa04613

Neutrophil extracellular trap formation

7.28E-05

P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P20160, P08311, P49913, P21730, P21462

PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1

Aminocaproic-acid

hsa04621

NOD-like receptor signaling pathway

3.10E-03

Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838

ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4

Aminocaproic-acid

hsa04625

C-type lectin receptor signaling pathway

3.87E-02

Q9ULY5, P20749, P01375, Q16539

CLEC4E, BCL3, TNF, MAPK14

Aminocaproic-acid

hsa04640

Hematopoietic cell lineage

1.39E-05

P13612, P14778, P27930, P11215, P15144, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375

ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49863	GZMK	Granzyme K	P13612	ITGA4	Integrin alpha-4	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P51124	GZMM	Granzyme M	P14778	IL1R1	Interleukin-1 receptor type 1	-0.886
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P51124	GZMM	Granzyme M	P27930	IL1R2	Interleukin-1 receptor type 2	-0.739
P49863	GZMK	Granzyme K	P27930	IL1R2	Interleukin-1 receptor type 2	-0.797
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P51124	GZMM	Granzyme M	P11215	ITGAM	Integrin alpha-M	-0.804
P49863	GZMK	Granzyme K	P15144	ANPEP	Aminopeptidase N	-0.752
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
P49863	GZMK	Granzyme K	P25063	CD24	Signal transducer CD24	-0.839
P08311	CTSG	Cathepsin G	P25063	CD24	Signal transducer CD24	0.902
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P51124	GZMM	Granzyme M	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.916
P49863	GZMK	Granzyme K	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.745
P49863	GZMK	Granzyme K	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.786
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P49863	GZMK	Granzyme K	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.784
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
P51124	GZMM	Granzyme M	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P51124	GZMM	Granzyme M	P09564	CD7	T-cell antigen CD7	0.903
P49863	GZMK	Granzyme K	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.882
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P49863	GZMK	Granzyme K	P01375	TNF	Tumor necrosis factor	-0.8
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733

Aminocaproic-acid

hsa04650

Natural killer cell mediated cytotoxicity

6.92E-11

P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, P26715

PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P49863	GZMK	Granzyme K	P01375	TNF	Tumor necrosis factor	-0.8
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P78314	SH3BP2	SH3 domain-binding protein 2	0.718
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P06239	LCK	Tyrosine-protein kinase Lck	-0.709
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P49863	GZMK	Granzyme K	P06239	LCK	Tyrosine-protein kinase Lck	0.846
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.764
P24158	PRTN3	Myeloblastin	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.816
P51124	GZMM	Granzyme M	O60880	SH2D1A	SH2 domain-containing protein 1A	0.743
P49863	GZMK	Granzyme K	O60880	SH2D1A	SH2 domain-containing protein 1A	0.899
P08311	CTSG	Cathepsin G	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.92
P20160	AZU1	Azurocidin	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.81
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703
P24158	PRTN3	Myeloblastin	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.729
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
P49863	GZMK	Granzyme K	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.893
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P20160	AZU1	Azurocidin	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.787
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P51124	GZMM	Granzyme M	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.834
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P24158	PRTN3	Myeloblastin	Q13241	KLRD1	Natural killer cells antigen CD94	-0.732
P49863	GZMK	Granzyme K	Q13241	KLRD1	Natural killer cells antigen CD94	0.809
P08311	CTSG	Cathepsin G	Q13241	KLRD1	Natural killer cells antigen CD94	-0.812
P20160	AZU1	Azurocidin	Q13241	KLRD1	Natural killer cells antigen CD94	-0.744
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.803
P24158	PRTN3	Myeloblastin	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.76
P51124	GZMM	Granzyme M	P26718	KLRK1	NKG2-D type II integral membrane protein	0.713
P49863	GZMK	Granzyme K	P26718	KLRK1	NKG2-D type II integral membrane protein	0.96
P08311	CTSG	Cathepsin G	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.875
P20160	AZU1	Azurocidin	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.763
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
P49863	GZMK	Granzyme K	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.775
P24158	PRTN3	Myeloblastin	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.77
P49863	GZMK	Granzyme K	P26717	KLRC2	NKG2-C type II integral membrane protein	0.891
P08311	CTSG	Cathepsin G	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
P20160	AZU1	Azurocidin	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.765
P24158	PRTN3	Myeloblastin	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
P49863	GZMK	Granzyme K	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.891
P08311	CTSG	Cathepsin G	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P20160	AZU1	Azurocidin	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.765

Aminocaproic-acid

hsa04657

IL-17 signaling pathway

4.00E-05

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Aminocaproic-acid

hsa04658

Th1 and Th2 cell differentiation

3.74E-16

Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P49863	GZMK	Granzyme K	Q04759	PRKCQ	Protein kinase C theta type	0.874
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P20160	AZU1	Azurocidin	Q04759	PRKCQ	Protein kinase C theta type	-0.912
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P51124	GZMM	Granzyme M	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.916
P49863	GZMK	Granzyme K	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.745
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
P49863	GZMK	Granzyme K	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.893
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P20160	AZU1	Azurocidin	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.787
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.734
P49863	GZMK	Granzyme K	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.786
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.901
P49863	GZMK	Granzyme K	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.756
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
P51124	GZMM	Granzyme M	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P06239	LCK	Tyrosine-protein kinase Lck	-0.709
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P49863	GZMK	Granzyme K	P06239	LCK	Tyrosine-protein kinase Lck	0.846
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P49863	GZMK	Granzyme K	Q14765	STAT4	Signal transducer and activator of transcription 4	0.848
P08311	CTSG	Cathepsin G	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.81
P20160	AZU1	Azurocidin	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.724
P49863	GZMK	Granzyme K	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.768
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P20160	AZU1	Azurocidin	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.833
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q9UL17	TBX21	T-box transcription factor TBX21	-0.73
P51124	GZMM	Granzyme M	Q9UL17	TBX21	T-box transcription factor TBX21	0.755
P49863	GZMK	Granzyme K	Q9UL17	TBX21	T-box transcription factor TBX21	0.918
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P51124	GZMM	Granzyme M	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.887
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.731
P49863	GZMK	Granzyme K	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.882
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P20160	AZU1	Azurocidin	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P51124	GZMM	Granzyme M	Q13761	RUNX3	Runt-related transcription factor 3	0.849
P49863	GZMK	Granzyme K	Q13761	RUNX3	Runt-related transcription factor 3	0.704

Aminocaproic-acid

hsa04659

Th17 cell differentiation

1.73E-12

Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P07766, P09693, P20963

PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P49863	GZMK	Granzyme K	Q04759	PRKCQ	Protein kinase C theta type	0.874
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P20160	AZU1	Azurocidin	Q04759	PRKCQ	Protein kinase C theta type	-0.912
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.901
P49863	GZMK	Granzyme K	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.756
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
P51124	GZMM	Granzyme M	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P06239	LCK	Tyrosine-protein kinase Lck	-0.709
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P49863	GZMK	Granzyme K	P06239	LCK	Tyrosine-protein kinase Lck	0.846
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P51124	GZMM	Granzyme M	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.887
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.731
P49863	GZMK	Granzyme K	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.882
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P20160	AZU1	Azurocidin	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P14778	IL1R1	Interleukin-1 receptor type 1	0.909
P51124	GZMM	Granzyme M	P14778	IL1R1	Interleukin-1 receptor type 1	-0.886
P49863	GZMK	Granzyme K	Q9HBE5	IL21R	Interleukin-21 receptor	0.722
P08311	CTSG	Cathepsin G	Q9HBE5	IL21R	Interleukin-21 receptor	-0.763
P20160	AZU1	Azurocidin	Q9HBE5	IL21R	Interleukin-21 receptor	-0.741
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q9UL17	TBX21	T-box transcription factor TBX21	-0.73
P51124	GZMM	Granzyme M	Q9UL17	TBX21	T-box transcription factor TBX21	0.755
P49863	GZMK	Granzyme K	Q9UL17	TBX21	T-box transcription factor TBX21	0.918
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P49863	GZMK	Granzyme K	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.768
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P20160	AZU1	Azurocidin	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.833
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P51124	GZMM	Granzyme M	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.916
P49863	GZMK	Granzyme K	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.745
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.734
P49863	GZMK	Granzyme K	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.786
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
P49863	GZMK	Granzyme K	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.893
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P20160	AZU1	Azurocidin	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.787

Aminocaproic-acid

hsa04660

T cell receptor signaling pathway

1.18E-09

P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49863	GZMK	Granzyme K	P01375	TNF	Tumor necrosis factor	-0.8
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P49863	GZMK	Granzyme K	Q04759	PRKCQ	Protein kinase C theta type	0.874
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P51124	GZMM	Granzyme M	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.834
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P49863	GZMK	Granzyme K	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.872
P08246	ELA2	Neutrophil elastase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.724
P08311	CTSG	Cathepsin G	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.705
P49863	GZMK	Granzyme K	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.952
P08246	ELA2	Neutrophil elastase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.782
P08311	CTSG	Cathepsin G	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P51124	GZMM	Granzyme M	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.916
P49863	GZMK	Granzyme K	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.745
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
P49863	GZMK	Granzyme K	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.893
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P49863	GZMK	Granzyme K	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.786
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P51124	GZMM	Granzyme M	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P49863	GZMK	Granzyme K	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.784
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P49863	GZMK	Granzyme K	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.793
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P49863	GZMK	Granzyme K	P06239	LCK	Tyrosine-protein kinase Lck	0.846
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P49863	GZMK	Granzyme K	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.756
P49863	GZMK	Granzyme K	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.716

Aminocaproic-acid

hsa04662

B cell receptor signaling pathway

1.07E-02

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Aminocaproic-acid

hsa04664

Fc epsilon RI signaling pathway

1.24E-03

P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917

TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5

Aminocaproic-acid

hsa04666

Fc gamma R-mediated phagocytosis

4.59E-02

Q02156

PRKCE

Aminocaproic-acid

hsa04668

TNF signaling pathway

1.94E-04

P01375, O00463, Q13489, Q16539, P25963, P09341, P20749, Q13077, P14780

TNF, TRAF5, BIRC3, MAPK14, NFKBIA, CXCL1, BCL3, TRAF1, MMP9

Aminocaproic-acid

hsa04670

Leukocyte transendothelial migration

4.20E-02

P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681

MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK

Aminocaproic-acid

hsa04713

Circadian entrainment

4.94E-02

P62873, P63092

GNB1, GNAS

Aminocaproic-acid

hsa04720

Long-term potentiation

2.62E-02

P18848, P22694, Q14643

ATF4, PRKACB, ITPR1

Aminocaproic-acid

hsa04723

Retrograde endocannabinoid signaling

4.94E-02

P48169, P62873

GABRA4, GNB1

Aminocaproic-acid

hsa04724

Glutamatergic synapse

2.90E-03

P43003, P63092, P62873, P63218, P50151, P15104

SLC1A3, GNAS, GNB1, GNG5, GNG10, GLUL

Aminocaproic-acid

hsa04725

Cholinergic synapse

3.86E-02

P22694, Q14643, P18848, P10415

PRKACB, ITPR1, ATF4, BCL2

Aminocaproic-acid

hsa04726

Serotonergic synapse

2.52E-02

P63092, P62873

GNAS, GNB1

Aminocaproic-acid

hsa04750

Inflammatory mediator regulation of TRP channels

4.75E-05

P14778, Q02156, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759

IL1R1, PRKCE, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ

Aminocaproic-acid

hsa04912

GnRH signaling pathway

2.62E-02

P18848, Q14643, P22694

ATF4, ITPR1, PRKACB

Aminocaproic-acid

hsa04913

Ovarian steroidogenesis

4.05E-02

P42330, P22694

AKR1C3, PRKACB

Aminocaproic-acid

hsa04915

Estrogen signaling pathway

1.67E-03

P14780, P22694, P18848, Q14643, P10415

MMP9, PRKACB, ATF4, ITPR1, BCL2

Aminocaproic-acid

hsa04918

Thyroid hormone synthesis

7.24E-04

P22694, P18848, Q14643

PRKACB, ATF4, ITPR1

Aminocaproic-acid

hsa04920

Adipocytokine signaling pathway

4.49E-02

P25963, P33121, Q04759, P01375

NFKBIA, ACSL1, PRKCQ, TNF

Aminocaproic-acid

hsa04922

Glucagon signaling pathway

2.11E-02

P22694, P06737, P18848, Q14643

PRKACB, PYGL, ATF4, ITPR1

Aminocaproic-acid

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Aminocaproic-acid

hsa04924

Renin secretion

3.64E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Aminocaproic-acid

hsa04925

Aldosterone synthesis and secretion

1.93E-02

Q14643, P18848, Q02156, P22694

ITPR1, ATF4, PRKCE, PRKACB

Aminocaproic-acid

hsa04927

Cortisol synthesis and secretion

3.17E-05

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Aminocaproic-acid

hsa04928

Parathyroid hormone synthesis, secretion and action

9.12E-04

Q14643, P22694, P23771, P18848, P10415

ITPR1, PRKACB, GATA3, ATF4, BCL2

Aminocaproic-acid

hsa04930

Type II diabetes mellitus

9.93E-03

Q02156

PRKCE

Aminocaproic-acid

hsa04931

Insulin resistance

2.64E-02

Q02156

PRKCE

Aminocaproic-acid

hsa04933

AGE-RAGE signaling pathway in diabetic complications

2.31E-02

Q02156

PRKCE

Aminocaproic-acid

hsa04934

Cushing syndrome

4.06E-02

Q14643, P22694, P49841, Q9UJU2, O00170

ITPR1, PRKACB, GSK3B, LEF1, AIP

Aminocaproic-acid

hsa04964

Proximal tubule bicarbonate reclamation

2.93E-02

P22748, P49448

CA4, GLUD2

Aminocaproic-acid

hsa04970

Salivary secretion

4.49E-02

P22694, Q14643, P17252, P49913

PRKACB, ITPR1, PRKCA, CAMP

Aminocaproic-acid

hsa04972

Pancreatic secretion

3.65E-02

P63092, P61586

GNAS, RHOA

Aminocaproic-acid

hsa04973

Carbohydrate digestion and absorption

1.66E-04

O43451, P42338

MGAM, PIK3CB

Aminocaproic-acid

hsa04974

Protein digestion and absorption

9.93E-03

Q7Z2H8

SLC36A1

Aminocaproic-acid

hsa05032

Morphine addiction

2.47E-03

P62873, P48169, P63092

GNB1, GABRA4, GNAS

Aminocaproic-acid

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.00E-05

P09341, P19875, P19174, P25024, P25025, P07948

CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN

Aminocaproic-acid

hsa05131

Shigellosis

3.34E-02

P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32

TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF

Aminocaproic-acid

hsa05132

Salmonella infection

2.98E-02

P51617, P25963, P01375, Q9UJU2, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509

IRAK1, NFKBIA, TNF, LEF1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3

Aminocaproic-acid

hsa05133

Pertussis

2.95E-03

P0DP23, P0C0L4

CALM1, C4A

Aminocaproic-acid

hsa05134

Legionellosis

4.00E-04

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Aminocaproic-acid

hsa05135

Yersinia infection

4.26E-02

P13612, P06239, Q16539, P01375, P49841, P01732

ITGA4, LCK, MAPK14, TNF, GSK3B, CD8A

Aminocaproic-acid

hsa05140

Leishmaniasis

1.18E-02

P14598, P13765, O60603, P25963, P01375, P51617, Q15080

NCF1, HLA-DOB, TLR2, NFKBIA, TNF, IRAK1, NCF4

Aminocaproic-acid

hsa05143

African trypanosomiasis

4.81E-02

P69905, P68871

HBA2, HBB

Aminocaproic-acid

hsa05144

Malaria

9.48E-05

P60033, O60603, P01375, P35443, P26718

CD81, TLR2, TNF, THBS4, KLRK1

Aminocaproic-acid

hsa05145

Toxoplasmosis

3.07E-02

P51617, P25963, P01375, P10415, Q13489, P13765, O60603

IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2

Aminocaproic-acid

hsa05146

Amoebiasis

1.43E-11

Q13751, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

LAMB3, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51124	GZMM	Granzyme M	Q13751	LAMB3	Laminin subunit beta-3	-0.702
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P24158	PRTN3	Myeloblastin	P09341	CXCL1	Growth-regulated alpha protein	0.751
P51124	GZMM	Granzyme M	P09341	CXCL1	Growth-regulated alpha protein	-0.733
P49863	GZMK	Granzyme K	P09341	CXCL1	Growth-regulated alpha protein	-0.846
P08311	CTSG	Cathepsin G	P09341	CXCL1	Growth-regulated alpha protein	0.877
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P51124	GZMM	Granzyme M	P19875	CXCL2	C-X-C motif chemokine 2	-0.739
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P51124	GZMM	Granzyme M	P14778	IL1R1	Interleukin-1 receptor type 1	-0.886
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P24158	PRTN3	Myeloblastin	P27930	IL1R2	Interleukin-1 receptor type 2	0.735
P51124	GZMM	Granzyme M	P27930	IL1R2	Interleukin-1 receptor type 2	-0.739
P49863	GZMK	Granzyme K	P27930	IL1R2	Interleukin-1 receptor type 2	-0.797
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P49863	GZMK	Granzyme K	P01375	TNF	Tumor necrosis factor	-0.8
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P24158	PRTN3	Myeloblastin	O60603	TLR2	Toll-like receptor 2	0.729
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P51124	GZMM	Granzyme M	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.834
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P51124	GZMM	Granzyme M	P11215	ITGAM	Integrin alpha-M	-0.804
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P24158	PRTN3	Myeloblastin	P05089	ARG1	Arginase-1	0.834
P49863	GZMK	Granzyme K	P05089	ARG1	Arginase-1	-0.92
P08311	CTSG	Cathepsin G	P05089	ARG1	Arginase-1	0.931
P24158	PRTN3	Myeloblastin	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.792
P49863	GZMK	Granzyme K	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.829
P08311	CTSG	Cathepsin G	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.847
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P51124	GZMM	Granzyme M	P12814	ACTN1	Alpha-actinin-1	-0.916
P49863	GZMK	Granzyme K	P12814	ACTN1	Alpha-actinin-1	-0.707
P08311	CTSG	Cathepsin G	P12814	ACTN1	Alpha-actinin-1	0.708
P24158	PRTN3	Myeloblastin	P08311	CTSG	Cathepsin G	0.914
P49863	GZMK	Granzyme K	P08311	CTSG	Cathepsin G	-0.892
P08311	CTSG	Cathepsin G	P08311	CTSG	Cathepsin G	1

Aminocaproic-acid

hsa05150

Staphylococcus aureus infection

4.36E-02

P0C0L4, P13646

C4A, KRT13

Aminocaproic-acid

hsa05152

Tuberculosis

3.11E-03

Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617

TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1

Aminocaproic-acid

hsa05161

Hepatitis B

2.33E-02

P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765

PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4

Aminocaproic-acid

hsa05163

Human cytomegalovirus infection

2.73E-04

P42338, P01375, P62873, P63218, P50151, P61586, P49841, P01106, P14778, Q13651, P25025, Q16539, P63092, O00463, P30101, P61769

PIK3CB, TNF, GNB1, GNG5, GNG10, RHOA, GSK3B, MYC, IL1R1, IL10RA, CXCR2, MAPK14, GNAS, TRAF5, PDIA3, B2M

Aminocaproic-acid

hsa05167

Kaposi sarcoma-associated herpesvirus infection

7.60E-03

P42338, P63218, P50151, P09341, P19875, P19174, P07948, P01106

PIK3CB, GNG5, GNG10, CXCL1, CXCL2, PLCG1, LYN, MYC

Aminocaproic-acid

hsa05169

Epstein-Barr virus infection

1.82E-03

P13765, P01106, Q13547, O00463, Q16539, P42338, P07948, P30101, Q13761, P24522, O75293, O60603, P07766, P09693, P20963

HLA-DOB, MYC, HDAC1, TRAF5, MAPK14, PIK3CB, LYN, PDIA3, RUNX3, GADD45A, GADD45B, TLR2, CD3E, CD3G, CD247

Aminocaproic-acid

hsa05170

Human immunodeficiency virus 1 infection

1.21E-04

P42338, P63218, P50151, P01375, P17252, O00463, P30101, Q14643, P01730, P51617, P25963, O60603, Q13315, O95067, P19174, P07766, P20963, P10415, Q13619, Q93034, Q9Y6Q5

PIK3CB, GNG5, GNG10, TNF, PRKCA, TRAF5, PDIA3, ITPR1, CD4, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, CD3E, CD247, BCL2, CUL4A, CUL5, AP1M2

Aminocaproic-acid

hsa05202

Transcriptional misregulation in cancer

4.42E-08

Q12778, Q15532, Q13315, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P24522

FOXO1, SS18, ATM, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
P24158	PRTN3	Myeloblastin	Q15532	SS18	Protein SSXT	-0.732
P08246	ELA2	Neutrophil elastase	Q15532	SS18	Protein SSXT	-0.806
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08311	CTSG	Cathepsin G	Q13315	ATM	Serine-protein kinase ATM	-0.709
P24158	PRTN3	Myeloblastin	P14780	MMP9	Matrix metalloproteinase-9	0.837
P08246	ELA2	Neutrophil elastase	P14780	MMP9	Matrix metalloproteinase-9	0.859
P08311	CTSG	Cathepsin G	P14780	MMP9	Matrix metalloproteinase-9	0.79
P20160	AZU1	Azurocidin	P14780	MMP9	Matrix metalloproteinase-9	0.734
P24158	PRTN3	Myeloblastin	P27930	IL1R2	Interleukin-1 receptor type 2	0.735
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
P08246	ELA2	Neutrophil elastase	P14923	JUP	Junction plakoglobin	-0.811
P24158	PRTN3	Myeloblastin	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.741
P08311	CTSG	Cathepsin G	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.909
P20160	AZU1	Azurocidin	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.78
P24158	PRTN3	Myeloblastin	Q16548	BCL2A1	Bcl-2-related protein A1	0.802
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P08311	CTSG	Cathepsin G	Q16548	BCL2A1	Bcl-2-related protein A1	0.79
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P24158	PRTN3	Myeloblastin	O15550	UTX	Lysine-specific demethylase 6A	0.776
P20160	AZU1	Azurocidin	O15550	UTX	Lysine-specific demethylase 6A	0.726
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P24158	PRTN3	Myeloblastin	P05164	MPO	Myeloperoxidase	0.979
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P08311	CTSG	Cathepsin G	P05164	MPO	Myeloperoxidase	0.956
P20160	AZU1	Azurocidin	P05164	MPO	Myeloperoxidase	0.97
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709
P08311	CTSG	Cathepsin G	P12838	DEFA4	Neutrophil defensin 4	0.817
P20160	AZU1	Azurocidin	P12838	DEFA4	Neutrophil defensin 4	0.742
P24158	PRTN3	Myeloblastin	P08246	ELA2	Neutrophil elastase	0.894
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P08311	CTSG	Cathepsin G	P08246	ELA2	Neutrophil elastase	0.792
P20160	AZU1	Azurocidin	P08246	ELA2	Neutrophil elastase	0.842
P24158	PRTN3	Myeloblastin	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.777
P08246	ELA2	Neutrophil elastase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.75
P08311	CTSG	Cathepsin G	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.853
P20160	AZU1	Azurocidin	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.758
P24158	PRTN3	Myeloblastin	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.772
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P08311	CTSG	Cathepsin G	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.799
P20160	AZU1	Azurocidin	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.761

Aminocaproic-acid

hsa05214

Glioma

4.10E-02

P09619, Q02750

PDGFRB, MAP2K1

Aminocaproic-acid

hsa05217

Basal cell carcinoma

3.39E-02

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Aminocaproic-acid

hsa05218

Melanoma

1.34E-02

P09619, Q02750

PDGFRB, MAP2K1

Aminocaproic-acid

hsa05222

Small cell lung cancer

2.79E-02

Q13489, P10415, P25963, Q13077, O00463, P24522

BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A

Aminocaproic-acid

hsa05230

Central carbon metabolism in cancer

4.10E-02

P09619, Q02750

PDGFRB, MAP2K1

Aminocaproic-acid

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

2.61E-07

P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P51124	GZMM	Granzyme M	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.834
P49863	GZMK	Granzyme K	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.872
P08311	CTSG	Cathepsin G	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.705
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P51124	GZMM	Granzyme M	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.916
P49863	GZMK	Granzyme K	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.745
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
P49863	GZMK	Granzyme K	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.893
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.734
P49863	GZMK	Granzyme K	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.786
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P06239	LCK	Tyrosine-protein kinase Lck	-0.709
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P49863	GZMK	Granzyme K	P06239	LCK	Tyrosine-protein kinase Lck	0.846
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	O60603	TLR2	Toll-like receptor 2	0.72
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P49863	GZMK	Granzyme K	Q04759	PRKCQ	Protein kinase C theta type	0.874
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.901
P49863	GZMK	Granzyme K	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.756
P51124	GZMM	Granzyme M	P01730	CD4	T-cell surface glycoprotein CD4	0.746

Aminocaproic-acid

hsa05310

Asthma

6.09E-07

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Aminocaproic-acid

hsa05321

Inflammatory bowel disease

1.48E-11

O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15144	ANPEP	Aminopeptidase N	O60603	TLR2	Toll-like receptor 2	0.885
P24158	PRTN3	Myeloblastin	O60603	TLR2	Toll-like receptor 2	0.729
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P15144	ANPEP	Aminopeptidase N	P01375	TNF	Tumor necrosis factor	0.878
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P49863	GZMK	Granzyme K	P01375	TNF	Tumor necrosis factor	-0.8
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P24158	PRTN3	Myeloblastin	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.796
P49863	GZMK	Granzyme K	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.882
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P20160	AZU1	Azurocidin	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.79
P15144	ANPEP	Aminopeptidase N	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.86
P24158	PRTN3	Myeloblastin	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.753
P49863	GZMK	Granzyme K	Q14765	STAT4	Signal transducer and activator of transcription 4	0.848
P08246	ELA2	Neutrophil elastase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.783
P08311	CTSG	Cathepsin G	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.81
P20160	AZU1	Azurocidin	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.724
P15144	ANPEP	Aminopeptidase N	Q9UL17	TBX21	T-box transcription factor TBX21	-0.755
P49863	GZMK	Granzyme K	Q9UL17	TBX21	T-box transcription factor TBX21	0.918
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P24158	PRTN3	Myeloblastin	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.81
P49863	GZMK	Granzyme K	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.768
P08246	ELA2	Neutrophil elastase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.724
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P20160	AZU1	Azurocidin	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.833
P49863	GZMK	Granzyme K	Q9HBE5	IL21R	Interleukin-21 receptor	0.722
P08311	CTSG	Cathepsin G	Q9HBE5	IL21R	Interleukin-21 receptor	-0.763
P20160	AZU1	Azurocidin	Q9HBE5	IL21R	Interleukin-21 receptor	-0.741

Aminocaproic-acid

hsa05322

Systemic lupus erythematosus

4.90E-03

P08246, P08311, P01375, P10747, P13765, Q6FI13, Q16778, P12814, P05455

ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST2H2BE, ACTN1, SSB

Aminocaproic-acid

hsa05323

Rheumatoid arthritis

2.72E-02

P01375, P13765, P09341, O60603

TNF, HLA-DOB, CXCL1, TLR2

Aminocaproic-acid

hsa05332

Graft-versus-host disease

5.65E-09

P13765, P10747, P01375, P26715, Q13241

HLA-DOB, CD28, TNF, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24158	PRTN3	Myeloblastin	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.796
P49863	GZMK	Granzyme K	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.882
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P20160	AZU1	Azurocidin	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.79
P15144	ANPEP	Aminopeptidase N	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.718
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P15144	ANPEP	Aminopeptidase N	P01375	TNF	Tumor necrosis factor	0.878
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P49863	GZMK	Granzyme K	P01375	TNF	Tumor necrosis factor	-0.8
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P15144	ANPEP	Aminopeptidase N	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.81
P24158	PRTN3	Myeloblastin	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
P49863	GZMK	Granzyme K	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.891
P08246	ELA2	Neutrophil elastase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.775
P08311	CTSG	Cathepsin G	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P20160	AZU1	Azurocidin	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.765
P15144	ANPEP	Aminopeptidase N	Q13241	KLRD1	Natural killer cells antigen CD94	-0.752
P24158	PRTN3	Myeloblastin	Q13241	KLRD1	Natural killer cells antigen CD94	-0.732
P49863	GZMK	Granzyme K	Q13241	KLRD1	Natural killer cells antigen CD94	0.809
P08246	ELA2	Neutrophil elastase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.7
P08311	CTSG	Cathepsin G	Q13241	KLRD1	Natural killer cells antigen CD94	-0.812
P20160	AZU1	Azurocidin	Q13241	KLRD1	Natural killer cells antigen CD94	-0.744

Aminocaproic-acid

hsa05418

Fluid shear stress and atherosclerosis

1.08E-03

Q16539, Q14145, P10599, P14780, P01375, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2

UniProtAC	Gene Name	Protein Name	Reported/ Predicted	DisGeNET	S_PV	S_drugability	S_HiSBiN	S_DisG

PharmaCoNets of Aminocaproic-acid (SPCN: 41.51 )

Aminocaproic-acid regulated-network (SDN: 13.61)

Community members of Aminocaproic-acid (SDC: 3.05)

PharmaCoNets of Aminocaproic-acid (S_PCN: 41.51 )

Aminocaproic-acid regulated-network (S_DN: 13.61)

Community members of Aminocaproic-acid (S_DC: 3.05)