PharmaCoNets of Amiloride (SPCN: 11.23 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Amiloridehsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Amiloridehsa00030Pentose phosphate pathway5.07E-033P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Amiloridehsa00190Oxidative phosphorylation4.36E-033Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Amiloridehsa00500Starch and sucrose metabolism3.86E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Amiloridehsa00630Glyoxylate and dicarboxylate metabolism1.29E-022P40925, P15104MDH1, GLULMore
Amiloridehsa00970Aminoacyl-tRNA biosynthesis5.32E-033O95363, P54136, Q15046FARS2, RARS1, KARSMore
Amiloridehsa01230Biosynthesis of amino acids3.91E-023P51854, Q99707, P50213TKTL1, MTR, IDH3AMore
Amiloridehsa04060Cytokine-cytokine receptor interaction1.28E-0210P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, P09341, P19875, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, CXCL1, CXCL2, CD4More
Amiloridehsa04061Viral protein interaction with cytokine and cytokine receptor2.95E-039P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Amiloridehsa04062Chemokine signaling pathway5.37E-039P25024, P09341, P19875, P07948, P42338, P19174, P63218, P50151, P43250CXCR1, CXCL1, CXCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6More
Amiloridehsa04064NF-kappa B signaling pathway5.90E-038P14778, P19174, P07948, P06239, O75293, P09341, P19875, Q06643IL1R1, PLCG1, LYN, LCK, GADD45B, CXCL1, CXCL2, LTBMore
Amiloridehsa04213Longevity regulating pathway - multiple species4.41E-034P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Amiloridehsa04612Antigen processing and presentation9.00E-038P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Amiloridehsa04613Neutrophil extracellular trap formation1.23E-035P11215, Q13547, P58876, Q16778, O60814ITGAM, HDAC1, H2BC5, HIST2H2BE, H2BC12More
Amiloridehsa04640Hematopoietic cell lineage1.89E-0313P13612, P14778, P27930, P11215, P15144, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNFMore
Amiloridehsa04650Natural killer cell mediated cytotoxicity1.16E-0311P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O75015, P26717, P26715PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Amiloridehsa04657IL-17 signaling pathway1.67E-027O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Amiloridehsa04658Th1 and Th2 cell differentiation1.20E-0814Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Amiloridehsa04659Th17 cell differentiation5.05E-0614Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, CD3E, CD3G, CD247More
Amiloridehsa04660T cell receptor signaling pathway4.62E-0515P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Amiloridehsa04662B cell receptor signaling pathway1.07E-025P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Amiloridehsa04664Fc epsilon RI signaling pathway1.29E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Amiloridehsa04668TNF signaling pathway3.19E-027P01375, O00463, Q16539, P09341, P20749, Q13077, P14780TNF, TRAF5, MAPK14, CXCL1, BCL3, TRAF1, MMP9More
Amiloridehsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Amiloridehsa04724Glutamatergic synapse2.81E-024P43003, P63218, P50151, P15104SLC1A3, GNG5, GNG10, GLULMore
Amiloridehsa04750Inflammatory mediator regulation of TRP channels4.06E-038P14778, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759IL1R1, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQMore
Amiloridehsa04934Cushing syndrome4.06E-025Q14643, P22694, P49841, Q9UJU2, O00170ITPR1, PRKACB, GSK3B, LEF1, AIPMore
Amiloridehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Amiloridehsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Amiloridehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P07948CXCL1, CXCL2, PLCG1, CXCR1, LYNMore
Amiloridehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Amiloridehsa05135Yersinia infection4.26E-026P13612, P06239, Q16539, P01375, P49841, P01732ITGA4, LCK, MAPK14, TNF, GSK3B, CD8AMore
Amiloridehsa05140Leishmaniasis4.50E-035P14598, O60603, P25963, P29350, Q15080NCF1, TLR2, NFKBIA, PTPN6, NCF4More
Amiloridehsa05146Amoebiasis2.13E-0512Q13751, P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P22694, P12814, P08311LAMB3, CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Amiloridehsa05163Human cytomegalovirus infection2.64E-027P42338, P63218, P50151, P01106, P14778, Q13651, P30101PIK3CB, GNG5, GNG10, MYC, IL1R1, IL10RA, PDIA3More
Amiloridehsa05167Kaposi sarcoma-associated herpesvirus infection7.60E-038P42338, P63218, P50151, P09341, P19875, P19174, P07948, P01106PIK3CB, GNG5, GNG10, CXCL1, CXCL2, PLCG1, LYN, MYCMore
Amiloridehsa05169Epstein-Barr virus infection1.27E-029P01106, Q13547, P42338, P07948, P30101, Q13761, O75293, P07766, P20963MYC, HDAC1, PIK3CB, LYN, PDIA3, RUNX3, GADD45B, CD3E, CD247More
Amiloridehsa05170Human immunodeficiency virus 1 infection3.15E-028P42338, P63218, P50151, P30101, P01730, P19174, P07766, P20963PIK3CB, GNG5, GNG10, PDIA3, CD4, PLCG1, CD3E, CD247More
Amiloridehsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Amiloridehsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Amiloridehsa05217Basal cell carcinoma3.39E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Amiloridehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.43E-0410P42338, O95267, P19174, P07766, P20963, P09693, P06239, Q04759, Q16539, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PRKCQ, MAPK14, CD4More
Amiloridehsa05310Asthma1.77E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Amiloridehsa05321Inflammatory bowel disease1.29E-036P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Amiloridehsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Amiloridehsa05332Graft-versus-host disease1.95E-024P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More

Community members of Amiloride (SDC: 1.55)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P49863GZMKGranzyme KPredicted00.01070.032500.0704
P51124GZMMGranzyme MPredicted00.05280.030100.0867
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)