PharmaCoNets of Amifampridine (SPCN: 1.09 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Amifampridinehsa00061Fatty acid biosynthesis4.83E-021P33121ACSL1More
Amifampridinehsa00190Oxidative phosphorylation3.50E-022Q16718, Q13488NDUFA5, TCIRG1More
Amifampridinehsa00600Sphingolipid metabolism3.01E-022Q9BX95, P06280SGPP1, GLAMore
Amifampridinehsa00620Pyruvate metabolism4.20E-022P40926, P14550MDH2, AKR1A1More
Amifampridinehsa01100Metabolic pathways4.56E-0211P15144, P32320, P06280, P24666, P33121, P42330, Q13093, Q9NY28, Q9BX95, P09960, Q16718ANPEP, CDA, GLA, ACP1, ACSL1, AKR1C3, PLA2G7, GALNT8, SGPP1, LTA4H, NDUFA5More
Amifampridinehsa03010Ribosome3.56E-0614P62753, P42677, P32969, P40429, P62917, P46776, Q9H0U6, Q07020, P62910, Q02878, P36578, P05386, P62249, P23396RPS6, RPS27, RPL9, RPL13A, RPL8, RPL27A, MRPL18, RPL18, RPL32, RPL6, RPL4, RPLP1, RPS16, RPS3More
Amifampridinehsa03020RNA polymerase9.86E-072Q9GZM3, P52435POLR2J2, POLR2JMore
Amifampridinehsa04024cAMP signaling pathway1.53E-024P49019, P22694, P20020, P48058HCAR3, PRKACB, ATP2B1, GRIA4More
Amifampridinehsa04145Phagosome2.75E-024Q15080, P14598, P68371, Q13488NCF4, NCF1, TUBB2C, TCIRG1More
Amifampridinehsa04217Necroptosis1.70E-025P01568, Q13489, P08238, O43633, Q08752IFNA21, BIRC3, HSP90AB1, CHMP2A, PPIDMore
Amifampridinehsa04650Natural killer cell mediated cytotoxicity2.11E-024P17252, O60880, P26717, P26715PRKCA, SH2D1A, KLRC2, KLRC1More
Amifampridinehsa04713Circadian entrainment1.69E-023P17252, P48058, P22694PRKCA, GRIA4, PRKACBMore
Amifampridinehsa04714Thermogenesis3.16E-023P22694, P33121, Q16718PRKACB, ACSL1, NDUFA5More
Amifampridinehsa04721Synaptic vesicle cycle1.14E-022Q13488, P31645TCIRG1, SLC6A4More
Amifampridinehsa04723Retrograde endocannabinoid signaling1.20E-034P17252, P48058, P22694, Q16718PRKCA, GRIA4, PRKACB, NDUFA5More
Amifampridinehsa04724Glutamatergic synapse1.31E-023P48058, P22694, P17252GRIA4, PRKACB, PRKCAMore
Amifampridinehsa04726Serotonergic synapse2.62E-023P22694, P17252, P31645PRKACB, PRKCA, SLC6A4More
Amifampridinehsa04911Insulin secretion3.01E-022P22694, P17252PRKACB, PRKCAMore
Amifampridinehsa04913Ovarian steroidogenesis1.28E-022P42330, P22694AKR1C3, PRKACBMore
Amifampridinehsa04918Thyroid hormone synthesis3.01E-022P22694, P17252PRKACB, PRKCAMore
Amifampridinehsa04925Aldosterone synthesis and secretion9.86E-033P17252, P22694, P20020PRKCA, PRKACB, ATP2B1More
Amifampridinehsa04961Endocrine and other factor-regulated calcium reabsorption9.85E-053P20020, P17252, P22694ATP2B1, PRKCA, PRKACBMore
Amifampridinehsa04962Vasopressin-regulated water reabsorption6.61E-032P22694, Q13561PRKACB, DCTN2More
Amifampridinehsa04970Salivary secretion7.14E-033P22694, P20020, P17252PRKACB, ATP2B1, PRKCAMore
Amifampridinehsa04972Pancreatic secretion1.48E-032P20020, P17252ATP2B1, PRKCAMore
Amifampridinehsa04976Bile secretion3.01E-022P22694, P08183PRKACB, ABCB1More
Amifampridinehsa05010Alzheimer disease7.11E-039O15239, P13073, P18848, O15169, P67870, P05141, P12236, P28070, P43686NDUFA1, COX4I1, ATF4, AXIN1, CSNK2B, SLC25A5, SLC25A6, PSMB4, PSMC4More
Amifampridinehsa05012Parkinson disease2.14E-027O15239, P13073, P05141, P12236, P18848, P28070, P43686NDUFA1, COX4I1, SLC25A5, SLC25A6, ATF4, PSMB4, PSMC4More
Amifampridinehsa05016Huntington disease2.46E-053Q9GZM3, P52435, Q9NYC9POLR2J2, POLR2J, DNAH9More
Amifampridinehsa05017Spinocerebellar ataxia4.66E-024P28070, P43686, P05141, P12236PSMB4, PSMC4, SLC25A5, SLC25A6More
Amifampridinehsa05020Prion disease1.55E-0310P46531, O15239, P13073, P18848, P05141, P12236, P28070, P43686, P67870, P51636NOTCH1, NDUFA1, COX4I1, ATF4, SLC25A5, SLC25A6, PSMB4, PSMC4, CSNK2B, CAV2More
Amifampridinehsa05022Pathways of neurodegeneration - multiple diseases5.20E-0415P67870, O15239, Q16718, P13073, P18848, Q13561, P48058, P05141, P12236, P17252, P20333, O15169, Q08752, P28070, P43686CSNK2B, NDUFA1, NDUFA5, COX4I1, ATF4, DCTN2, GRIA4, SLC25A5, SLC25A6, PRKCA, TNFRSF1B, AXIN1, PPID, PSMB4, PSMC4More
Amifampridinehsa05031Amphetamine addiction1.69E-023P48058, P22694, P17252GRIA4, PRKACB, PRKCAMore
Amifampridinehsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Amifampridinehsa05110Vibrio cholerae infection3.01E-022P17252, P22694PRKCA, PRKACBMore
Amifampridinehsa05171Coronavirus disease - COVID-191.08E-0413P23396, P62753, P62249, P42677, P40429, P36578, Q02878, P62917, P32969, Q07020, P46776, P62910, P05386RPS3, RPS6, RPS16, RPS27, RPL13A, RPL4, RPL6, RPL8, RPL9, RPL18, RPL27A, RPL32, RPLP1More
Amifampridinehsa05224Breast cancer3.88E-023P46531, Q9UM47, O15169NOTCH1, NOTCH3, AXIN1More
Amifampridinehsa05415Diabetic cardiomyopathy2.75E-024P17252, P14598, Q15080, Q16718PRKCA, NCF1, NCF4, NDUFA5More

Community members of Amifampridine (SDC: 0.30)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P16389KCNA2Potassium voltageNonegated channel subfamily A member 2Predicted00.01310.083500.1736
P17658KCNA6Potassium voltageNonegated channel subfamily A member 6Predicted00.28270.078500.2984
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
Q9ULS6KCNS2Potassium voltageNonegated channel subfamily S member 2Predicted00.19550.041200.1801
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)