| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Ambrisentan | hsa00030 | Pentose phosphate pathway | 3.74E-02 | 2 | P60891, P52209 | PRPS1, PGD | More | | | Ambrisentan | hsa00052 | Galactose metabolism | 4.27E-02 | 2 | P06280, O43451 | GLA, MGAM | More | | | Ambrisentan | hsa00071 | Fatty acid degradation | 4.66E-02 | 3 | O75521, P11766, P33121 | ECI2, ADH5, ACSL1 | More | | | Ambrisentan | hsa00190 | Oxidative phosphorylation | 3.56E-02 | 3 | Q16718, Q13488, O14521 | NDUFA5, TCIRG1, SDHD | More | | | Ambrisentan | hsa00230 | Purine metabolism | 1.81E-02 | 2 | P20839, Q02153 | IMPDH1, GUCY1B3 | More | | | Ambrisentan | hsa00260 | Glycine, serine and threonine metabolism | 1.99E-02 | 1 | P22557 | ALAS2 | More | | | Ambrisentan | hsa00310 | Lysine degradation | 2.59E-02 | 2 | Q96KQ7, P51648 | EHMT2, ALDH3A2 | More | | | Ambrisentan | hsa00500 | Starch and sucrose metabolism | 3.85E-04 | 3 | O43451, P46976, P06737 | MGAM, GYG1, PYGL | More | | | Ambrisentan | hsa00512 | Mucin type O-glycan biosynthesis | 3.19E-03 | 3 | O95395, Q8N4A0, Q9NY28 | GCNT3, GALNT4, GALNT8 | More | | | Ambrisentan | hsa00533 | Glycosaminoglycan biosynthesis - keratan sulfate | 1.91E-02 | 1 | Q9NY97 | B3GNT2 | More | | | Ambrisentan | hsa00565 | Ether lipid metabolism | 3.94E-02 | 1 | Q8N661 | TMEM86B | More | | | Ambrisentan | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | | Ambrisentan | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | | Ambrisentan | hsa00600 | Sphingolipid metabolism | 3.76E-02 | 1 | P15289 | ARSA | More | | | Ambrisentan | hsa00601 | Glycosphingolipid biosynthesis - lacto and neolacto series | 3.78E-02 | 1 | Q9NY97 | B3GNT2 | More | | | Ambrisentan | hsa00630 | Glyoxylate and dicarboxylate metabolism | 1.88E-07 | 2 | P40925, P15104 | MDH1, GLUL | More | | | Ambrisentan | hsa00670 | One carbon pool by folate | 3.62E-02 | 1 | P00374 | DHFR | More | | | Ambrisentan | hsa00730 | Thiamine metabolism | 2.27E-02 | 2 | P05186, P24666 | ALPL, ACP1 | More | | | Ambrisentan | hsa00790 | Folate biosynthesis | 3.62E-02 | 1 | P00374 | DHFR | More | | | Ambrisentan | hsa00920 | Sulfur metabolism | 1.78E-02 | 1 | Q16762 | TST | More | | | Ambrisentan | hsa00970 | Aminoacyl-tRNA biosynthesis | 6.28E-04 | 3 | O95363, P14868, Q15046 | FARS2, DARS, KARS | More | | | Ambrisentan | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 9.14E-03 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Ambrisentan | hsa00982 | Drug metabolism - cytochrome P450 | 9.14E-03 | 2 | P11712, P78417 | CYP2C9, GSTO1 | More | | | Ambrisentan | hsa01210 | 2-Oxocarboxylic acid metabolism | 1.91E-02 | 1 | P50213 | IDH3A | More | | | Ambrisentan | hsa01522 | Endocrine resistance | 6.25E-03 | 5 | P14780, P22694, Q9UM47, P10415, Q13323 | MMP9, PRKACB, NOTCH3, BCL2, BIK | More | | | Ambrisentan | hsa02010 | ABC transporters | 4.48E-02 | 1 | Q8IZY2 | ABCA7 | More | | | Ambrisentan | hsa03008 | Ribosome biogenesis in eukaryotes | 4.94E-02 | 2 | P19784, P67870 | CSNK2A2, CSNK2B | More | | | Ambrisentan | hsa03013 | RNA transport | 8.90E-06 | 17 | P52298, Q09161, O14893, P38919, Q15287, Q9UBU9, P37198, Q7Z3B4, P35658, P63279, Q14152, P55884, O15371, O75822, P78345, P20042, Q9Y6A5 | NCBP2, NCBP1, GEMIN2, EIF4A3, RNPS1, NXF1, NUP62, NUP54, NUP214, UBE2I, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, EIF2S2, TACC3 | More | | | Ambrisentan | hsa03030 | DNA replication | 5.00E-02 | 1 | P27694 | RPA1 | More | | | Ambrisentan | hsa03040 | Spliceosome | 2.66E-10 | 17 | Q14562, O43143, O60508, P08579, Q15427, P26368, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643 | DHX8, DHX15, CDC40, SNRPB2, SF3B4, U2AF2, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P29375 | JARID1A | Lysine-specific demethylase 5A | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | 0.781 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | 0.775 | | P29375 | JARID1A | Lysine-specific demethylase 5A | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | 0.794 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | 0.871 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.76 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.76 | | P29375 | JARID1A | Lysine-specific demethylase 5A | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.875 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.716 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O60508 | CDC40 | Pre-mRNA-processing factor 17 | -0.812 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | 0.787 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.822 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Q15427 | SF3B4 | Splicing factor 3B subunit 4 | 0.71 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P26368 | U2AF2 | Splicing factor U2AF 65 kDa subunit | -0.751 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P38159 | RBMX | RNA-binding motif protein, X chromosome | 0.733 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P61978 | HNRPK | Heterogeneous nuclear ribonucleoprotein K | 0.784 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.74 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.712 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.725 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.827 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.749 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.822 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.862 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.783 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.798 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84103 | SFRS3 | Serine/arginine-rich splicing factor 3 | -0.773 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.732 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.943 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | -0.822 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.876 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.766 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | -0.802 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q9Y2W2 | WBP11 | WW domain-binding protein 11 | 0.711 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q9Y2W2 | WBP11 | WW domain-binding protein 11 | -0.743 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | -0.766 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75643 | ASCC3L1 | U5 small nuclear ribonucleoprotein 200 kDa helicase | -0.745 |
| | Ambrisentan | hsa03050 | Proteasome | 4.83E-02 | 1 | P55036 | PSMD4 | More | | | Ambrisentan | hsa03060 | Protein export | 5.99E-04 | 4 | Q15070, P37108, O76094, Q15005 | OXA1L, SRP14, SRP72, SPCS2 | More | | | Ambrisentan | hsa03430 | Mismatch repair | 4.38E-02 | 1 | P20585 | MSH3 | More | | | Ambrisentan | hsa03450 | Non-homologous end-joining | 4.48E-03 | 1 | P78527 | PRKDC | More | | | Ambrisentan | hsa04012 | ErbB signaling pathway | 3.74E-02 | 3 | P21860, Q13557, O14944 | ERBB3, CAMK2D, EREG | More | | | Ambrisentan | hsa04014 | Ras signaling pathway | 6.52E-05 | 11 | P42338, P20827, Q9NRA1, P49767, Q13009, Q7LDG7, P0DP23, P62873, P63218, P50151, P19174 | PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, RASGRP2, CALM1, GNB1, GNG5, GNG10, PLCG1 | More | | | Ambrisentan | hsa04015 | Rap1 signaling pathway | 2.64E-03 | 10 | P20827, P49767, P06213, Q96FS4, P11215, Q13009, O00522, Q7LDG7, P42338, P19174 | EFNA1, VEGFC, INSR, SIPA1, ITGAM, TIAM1, KRIT1, RASGRP2, PIK3CB, PLCG1 | More | | | Ambrisentan | hsa04020 | Calcium signaling pathway | 6.50E-04 | 6 | Q96DU7, P45880, Q13557, P21860, P51828, P23634 | ITPKC, VDAC2, CAMK2D, ERBB3, ADCY7, ATP2B4 | More | | | Ambrisentan | hsa04022 | cGMP-PKG signaling pathway | 4.72E-02 | 4 | Q99941, P23634, P51828, P45880 | CREBL1, ATP2B4, ADCY7, VDAC2 | More | | | Ambrisentan | hsa04024 | cAMP signaling pathway | 4.25E-03 | 7 | P63092, P42338, P26678, P0DP23, P61586, Q13370, Q13009 | GNAS, PIK3CB, PLN, CALM1, RHOA, PDE3B, TIAM1 | More | | | Ambrisentan | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 4.48E-02 | 5 | P09341, P19875, P25024, P25025, P14784 | CXCL1, CXCL2, CXCR1, CXCR2, IL2RB | More | | | Ambrisentan | hsa04062 | Chemokine signaling pathway | 4.82E-06 | 18 | P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q7LDG7, Q13009, P14598, P42224, P25963, Q8WYR1 | CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, NCF1, STAT1, NFKBIA, PIK3R5 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q13547 | HDAC1 | Histone deacetylase 1 | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | -0.803 | | Q13547 | HDAC1 | Histone deacetylase 1 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | -0.719 | | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P09769 | FGR | Tyrosine-protein kinase Fgr | 0.796 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.782 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P07948 | LYN | Tyrosine-protein kinase Lyn | 0.971 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.869 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.82 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.703 | | Q13547 | HDAC1 | Histone deacetylase 1 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.864 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.704 | | Q13547 | HDAC1 | Histone deacetylase 1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.716 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43250 | GRK6 | G protein-coupled receptor kinase 6 | 0.818 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | -0.746 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.706 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.785 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.783 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 |
| | Ambrisentan | hsa04064 | NF-kappa B signaling pathway | 1.04E-08 | 18 | P10415, Q13489, P25963, P51617, O00463, P14778, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q13315, P24522, P09341, P19875, Q06643 | BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, ATM, GADD45A, CXCL1, CXCL2, LTB | More | | | Ambrisentan | hsa04070 | Phosphatidylinositol signaling system | 3.07E-04 | 6 | P19174, P0DP23, P42338, P23743, P49619, P27987 | PLCG1, CALM1, PIK3CB, DGKA, DGKG, ITPKB | More | | | Ambrisentan | hsa04071 | Sphingolipid signaling pathway | 1.74E-08 | 8 | P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415 | PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P22894 | MMP8 | Neutrophil collagenase | P17252 | PRKCA | Protein kinase C alpha type | -0.759 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P17252 | PRKCA | Protein kinase C alpha type | -0.757 | | P08246 | ELA2 | Neutrophil elastase | P17252 | PRKCA | Protein kinase C alpha type | -0.735 | | P22894 | MMP8 | Neutrophil collagenase | P21453 | S1PR1 | Sphingosine 1-phosphate receptor 1 | -0.721 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P21453 | S1PR1 | Sphingosine 1-phosphate receptor 1 | -0.832 | | P08246 | ELA2 | Neutrophil elastase | P21453 | S1PR1 | Sphingosine 1-phosphate receptor 1 | -0.725 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P21453 | S1PR1 | Sphingosine 1-phosphate receptor 1 | 0.934 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | -0.901 | | P22894 | MMP8 | Neutrophil collagenase | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | -0.787 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | -0.733 | | P08246 | ELA2 | Neutrophil elastase | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | -0.797 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | 0.777 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | P22894 | MMP8 | Neutrophil collagenase | P01375 | TNF | Tumor necrosis factor | 0.728 | | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | -0.828 | | P22894 | MMP8 | Neutrophil collagenase | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | -0.834 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | -0.773 | | P08246 | ELA2 | Neutrophil elastase | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | -0.865 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | 0.721 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.869 | | P22894 | MMP8 | Neutrophil collagenase | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.879 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.884 | | P08246 | ELA2 | Neutrophil elastase | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.847 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | 0.7 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.721 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.765 | | P22894 | MMP8 | Neutrophil collagenase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.959 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.865 | | P08246 | ELA2 | Neutrophil elastase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.942 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.713 |
| | Ambrisentan | hsa04072 | Phospholipase D signaling pathway | 5.37E-03 | 8 | P42338, P61586, P43657, P25024, P25025, P19174, O14986, P63092 | PIK3CB, RHOA, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, GNAS | More | | | Ambrisentan | hsa04080 | Neuroactive ligand-receptor interaction | 1.63E-06 | 9 | P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550 | CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2 | More | | | Ambrisentan | hsa04110 | Cell cycle | 1.96E-03 | 6 | P06493, P78527, P30304, P33981, P01106, Q13547 | CDK1, PRKDC, CDC25A, TTK, MYC, HDAC1 | More | | | Ambrisentan | hsa04114 | Oocyte meiosis | 1.33E-02 | 4 | P51812, Q02750, P16298, Q17RY0 | RPS6KA3, MAP2K1, PPP3CB, CPEB4 | More | | | Ambrisentan | hsa04115 | p53 signaling pathway | 3.57E-02 | 5 | P24522, Q13315, Q53FA7, O95067, P10415 | GADD45A, ATM, TP53I3, CCNB2, BCL2 | More | | | Ambrisentan | hsa04120 | Ubiquitin mediated proteolysis | 7.04E-05 | 6 | Q9UBT2, Q13042, Q15751, O95071, Q14669, P0CG47 | SAE2, CDC16, HERC1, UBR5, TRIP12, UBB | More | | | Ambrisentan | hsa04122 | Sulfur relay system | 1.78E-02 | 1 | Q16762 | TST | More | | | Ambrisentan | hsa04136 | Autophagy - other | 3.53E-02 | 1 | O94817 | ATG12 | More | | | Ambrisentan | hsa04137 | Mitophagy - animal | 6.72E-04 | 4 | P19784, P67870, Q07817, P0CG47 | CSNK2A2, CSNK2B, BCL2L1, UBB | More | | | Ambrisentan | hsa04140 | Autophagy - animal | 5.69E-04 | 5 | P22694, Q14643, P10415, Q9H1Y0, Q04759 | PRKACB, ITPR1, BCL2, ATG5, PRKCQ | More | | | Ambrisentan | hsa04141 | Protein processing in endoplasmic reticulum | 1.33E-03 | 10 | P30101, P60604, Q99941, O75460, P11142, Q9H3Z4, P07900, P08238, Q9H173, Q9UNL2 | PDIA3, UBE2G2, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SIL1, SSR3 | More | | | Ambrisentan | hsa04142 | Lysosome | 2.01E-03 | 6 | P22304, P38571, Q13510, Q9UJJ9, P07602, P49279 | IDS, LIPA, ASAH1, GNPTG, PSAP, SLC11A1 | More | | | Ambrisentan | hsa04144 | Endocytosis | 6.92E-04 | 7 | P0DMV8, Q9H444, O75351, P62491, Q8WU79, Q14161, Q9UMY4 | HSPA1A, CHMP4B, VPS4B, RAB11A, SMAP1L, GIT2, SNX12 | More | | | Ambrisentan | hsa04145 | Phagosome | 2.28E-09 | 12 | O75015, P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765 | FCGR3B, ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P22894 | MMP8 | Neutrophil collagenase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.734 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.737 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P11215 | ITGAM | Integrin alpha-M | -0.78 | | P22894 | MMP8 | Neutrophil collagenase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.963 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.918 | | P08246 | ELA2 | Neutrophil elastase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.945 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.951 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.731 | | P22894 | MMP8 | Neutrophil collagenase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.74 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.785 | | P08246 | ELA2 | Neutrophil elastase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.762 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.844 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q71U36 | TUBA1A | Tubulin alpha-1A chain | -0.866 | | P22894 | MMP8 | Neutrophil collagenase | Q13509 | TUBB3 | Tubulin beta-3 chain | 0.707 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q13509 | TUBB3 | Tubulin beta-3 chain | 0.789 | | P08246 | ELA2 | Neutrophil elastase | Q13509 | TUBB3 | Tubulin beta-3 chain | 0.724 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.809 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P68371 | TUBB2C | Tubulin beta-4B chain | 0.741 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P68371 | TUBB2C | Tubulin beta-4B chain | -0.766 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q13488 | TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 | 0.717 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q13488 | TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 | 0.759 | | P08246 | ELA2 | Neutrophil elastase | Q13488 | TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 | 0.71 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13488 | TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 | -0.718 | | P22894 | MMP8 | Neutrophil collagenase | P05164 | MPO | Myeloperoxidase | 0.905 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P05164 | MPO | Myeloperoxidase | 0.805 | | P08246 | ELA2 | Neutrophil elastase | P05164 | MPO | Myeloperoxidase | 0.903 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P05164 | MPO | Myeloperoxidase | -0.81 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P05164 | MPO | Myeloperoxidase | -0.866 | | P22894 | MMP8 | Neutrophil collagenase | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | O60603 | TLR2 | Toll-like receptor 2 | 0.942 | | P08246 | ELA2 | Neutrophil elastase | O60603 | TLR2 | Toll-like receptor 2 | 0.853 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O60603 | TLR2 | Toll-like receptor 2 | -0.884 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | O60603 | TLR2 | Toll-like receptor 2 | -0.717 | | P22894 | MMP8 | Neutrophil collagenase | P35443 | THBS4 | Thrombospondin-4 | 0.876 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P35443 | THBS4 | Thrombospondin-4 | 0.855 | | P08246 | ELA2 | Neutrophil elastase | P35443 | THBS4 | Thrombospondin-4 | 0.871 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P35443 | THBS4 | Thrombospondin-4 | -0.765 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P35443 | THBS4 | Thrombospondin-4 | -0.906 | | P22894 | MMP8 | Neutrophil collagenase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.797 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.792 | | P08246 | ELA2 | Neutrophil elastase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.729 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.754 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.795 |
| | Ambrisentan | hsa04150 | mTOR signaling pathway | 3.60E-02 | 3 | Q02750, Q9NQL2, P51812 | MAP2K1, RRAGD, RPS6KA3 | More | | | Ambrisentan | hsa04151 | PI3K-Akt signaling pathway | 1.89E-03 | 12 | P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281 | PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3 | More | | | Ambrisentan | hsa04210 | Apoptosis | 1.54E-03 | 11 | Q13315, P10415, Q13489, O76075, P25963, P01375, P24522, Q16548, Q13077, P43234, Q14643 | ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, CTSO, ITPR1 | More | | | Ambrisentan | hsa04213 | Longevity regulating pathway - multiple species | 5.20E-03 | 6 | P42338, Q9Y4H2, Q08828, P0DMV8, P11142, Q13547 | PIK3CB, IRS2, ADCY1, HSPA1A, HSPA8, HDAC1 | More | | | Ambrisentan | hsa04261 | Adrenergic signaling in cardiomyocytes | 3.98E-02 | 4 | P51828, Q99941, Q13557, P23634 | ADCY7, CREBL1, CAMK2D, ATP2B4 | More | | | Ambrisentan | hsa04270 | Vascular smooth muscle contraction | 1.53E-02 | 4 | P0DP23, Q08828, P35579, P35318 | CALM1, ADCY1, MYH9, ADM | More | | | Ambrisentan | hsa04310 | Wnt signaling pathway | 4.17E-03 | 3 | P61586, P19784, P67870 | RHOA, CSNK2A2, CSNK2B | More | | | Ambrisentan | hsa04330 | Notch signaling pathway | 2.46E-03 | 3 | Q92542, P49768, P46531 | NCSTN, PSEN1, NOTCH1 | More | | | Ambrisentan | hsa04340 | Hedgehog signaling pathway | 9.48E-05 | 4 | P49841, P22694, Q13635, P10415 | GSK3B, PRKACB, PTCH1, BCL2 | More | | | Ambrisentan | hsa04360 | Axon guidance | 2.47E-03 | 7 | P16333, P20827, O95631, P42338, P07332, P23528, P19174 | NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1 | More | | | Ambrisentan | hsa04370 | VEGF signaling pathway | 2.68E-03 | 3 | P16298, Q05397, Q02750 | PPP3CB, PTK2, MAP2K1 | More | | | Ambrisentan | hsa04371 | Apelin signaling pathway | 3.84E-05 | 10 | P62873, P63218, P50151, Q8WYR1, Q13370, Q14814, Q14344, Q13485, P84022, P0DP23 | GNB1, GNG5, GNG10, PIK3R5, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, CALM1 | More | | | Ambrisentan | hsa04380 | Osteoclast differentiation | 1.02E-02 | 6 | Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149 | GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2 | More | | | Ambrisentan | hsa04390 | Hippo signaling pathway | 4.35E-02 | 2 | P63261, O15105 | ACTG1, SMAD7 | More | | | Ambrisentan | hsa04510 | Focal adhesion | 4.07E-02 | 3 | O14986, P61586, Q16363 | PIP5K1B, RHOA, LAMA4 | More | | | Ambrisentan | hsa04514 | Cell adhesion molecules | 6.68E-04 | 4 | P23229, P16109, P30511, O00501 | ITGA6, SELP, HLA-F, CLDN5 | More | | | Ambrisentan | hsa04520 | Adherens junction | 1.38E-04 | 3 | P19784, P67870, P61586 | CSNK2A2, CSNK2B, RHOA | More | | | Ambrisentan | hsa04530 | Tight junction | 3.70E-04 | 7 | P63261, P16989, P56750, O00501, Q92974, Q14247, P24844 | ACTG1, CSDA, CLDN17, CLDN5, ARHGEF2, CTTN, MYL9 | More | | | Ambrisentan | hsa04540 | Gap junction | 7.64E-04 | 6 | P22694, Q13509, P68371, Q71U36, Q9NRA1, Q14643 | PRKACB, TUBB3, TUBB2C, TUBA1A, PDGFC, ITPR1 | More | | | Ambrisentan | hsa04610 | Complement and coagulation cascades | 1.91E-03 | 1 | P0C0L4 | C4A | More | | | Ambrisentan | hsa04612 | Antigen processing and presentation | 1.62E-04 | 8 | P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375 | HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF | More | | | Ambrisentan | hsa04613 | Neutrophil extracellular trap formation | 3.27E-10 | 24 | P19174, P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539 | PLCG1, PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| P51955 | NEK2 | Serine/threonine-protein kinase Nek2 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.785 | | P22894 | MMP8 | Neutrophil collagenase | P17252 | PRKCA | Protein kinase C alpha type | -0.759 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P17252 | PRKCA | Protein kinase C alpha type | -0.757 | | P08246 | ELA2 | Neutrophil elastase | P17252 | PRKCA | Protein kinase C alpha type | -0.735 | | P51955 | NEK2 | Serine/threonine-protein kinase Nek2 | P11215 | ITGAM | Integrin alpha-M | 0.795 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | P22894 | MMP8 | Neutrophil collagenase | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | O60603 | TLR2 | Toll-like receptor 2 | 0.942 | | P08246 | ELA2 | Neutrophil elastase | O60603 | TLR2 | Toll-like receptor 2 | 0.853 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | O60603 | TLR2 | Toll-like receptor 2 | -0.717 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P05164 | MPO | Myeloperoxidase | 0.812 | | P22894 | MMP8 | Neutrophil collagenase | P05164 | MPO | Myeloperoxidase | 0.905 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P05164 | MPO | Myeloperoxidase | 0.805 | | P08246 | ELA2 | Neutrophil elastase | P05164 | MPO | Myeloperoxidase | 0.903 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P05164 | MPO | Myeloperoxidase | -0.866 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08246 | ELA2 | Neutrophil elastase | 0.859 | | P22894 | MMP8 | Neutrophil collagenase | P08246 | ELA2 | Neutrophil elastase | 0.985 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P08246 | ELA2 | Neutrophil elastase | 0.846 | | P08246 | ELA2 | Neutrophil elastase | P08246 | ELA2 | Neutrophil elastase | 1 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P08246 | ELA2 | Neutrophil elastase | -0.76 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.9 | | P22894 | MMP8 | Neutrophil collagenase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.877 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.799 | | P08246 | ELA2 | Neutrophil elastase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.889 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | -0.819 | | P51955 | NEK2 | Serine/threonine-protein kinase Nek2 | Q13547 | HDAC1 | Histone deacetylase 1 | -0.731 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.74 | | P22894 | MMP8 | Neutrophil collagenase | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.909 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.833 | | P08246 | ELA2 | Neutrophil elastase | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.907 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.754 | | P51955 | NEK2 | Serine/threonine-protein kinase Nek2 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.702 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P51955 | NEK2 | Serine/threonine-protein kinase Nek2 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.702 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P51955 | NEK2 | Serine/threonine-protein kinase Nek2 | Q16778 | HIST2H2BE | Histone H2B type 2-E | 0.728 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | O60814 | H2BC12 | Histone H2B type 1-K | 0.728 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.845 | | P22894 | MMP8 | Neutrophil collagenase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.74 | | P08246 | ELA2 | Neutrophil elastase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.762 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.869 | | P22894 | MMP8 | Neutrophil collagenase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.963 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.918 | | P08246 | ELA2 | Neutrophil elastase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.945 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.731 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20160 | AZU1 | Azurocidin | 0.734 | | P22894 | MMP8 | Neutrophil collagenase | P20160 | AZU1 | Azurocidin | 0.824 | | P08246 | ELA2 | Neutrophil elastase | P20160 | AZU1 | Azurocidin | 0.842 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P20160 | AZU1 | Azurocidin | -0.799 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08311 | CTSG | Cathepsin G | 0.79 | | P22894 | MMP8 | Neutrophil collagenase | P08311 | CTSG | Cathepsin G | 0.8 | | P08246 | ELA2 | Neutrophil elastase | P08311 | CTSG | Cathepsin G | 0.792 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P08311 | CTSG | Cathepsin G | -0.811 | | P22894 | MMP8 | Neutrophil collagenase | P49913 | CAMP | Cathelicidin antimicrobial peptide | 0.7 | | P08246 | ELA2 | Neutrophil elastase | P49913 | CAMP | Cathelicidin antimicrobial peptide | 0.807 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.928 | | P22894 | MMP8 | Neutrophil collagenase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.734 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.737 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.942 | | P22894 | MMP8 | Neutrophil collagenase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.756 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.875 | | P08246 | ELA2 | Neutrophil elastase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.703 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | -0.772 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.912 | | P22894 | MMP8 | Neutrophil collagenase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.88 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.888 | | P08246 | ELA2 | Neutrophil elastase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.85 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O43315 | AQP9 | Aquaporin-9 | 0.837 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | O43315 | AQP9 | Aquaporin-9 | 0.79 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.721 |
| | Ambrisentan | hsa04621 | NOD-like receptor signaling pathway | 2.68E-04 | 14 | Q16539, Q14643, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P12838 | MAPK14, ITPR1, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA4 | More | | | Ambrisentan | hsa04623 | Cytosolic DNA-sensing pathway | 2.59E-02 | 2 | P01568, P25963 | IFNA21, NFKBIA | More | | | Ambrisentan | hsa04625 | C-type lectin receptor signaling pathway | 3.87E-02 | 4 | Q9ULY5, P20749, P01375, Q16539 | CLEC4E, BCL3, TNF, MAPK14 | More | | | Ambrisentan | hsa04630 | JAK-STAT signaling pathway | 3.20E-02 | 4 | P01106, P42224, P14784, Q13651 | MYC, STAT1, IL2RB, IL10RA | More | | | Ambrisentan | hsa04640 | Hematopoietic cell lineage | 1.37E-02 | 7 | P14778, P27930, P11215, P25063, P07766, P01732, P09564 | IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7 | More | | | Ambrisentan | hsa04650 | Natural killer cell mediated cytotoxicity | 9.04E-08 | 15 | P16298, P50591, P19174, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715 | PPP3CB, TNFSF10, PLCG1, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| P11511 | CYP19A1 | Aromatase | P16298 | PPP3CB | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform | 0.706 | | P11511 | CYP19A1 | Aromatase | P50591 | TNFSF10 | Tumor necrosis factor ligand superfamily member 10 | 0.701 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P78314 | SH3BP2 | SH3 domain-binding protein 2 | 0.748 | | P13612 | ITGA4 | Integrin alpha-4 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.732 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | Q13547 | HDAC1 | Histone deacetylase 1 | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.786 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.751 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.869 | | P13612 | ITGA4 | Integrin alpha-4 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.768 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.722 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.74 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | P11511 | CYP19A1 | Aromatase | Q02750 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | 0.783 | | P13612 | ITGA4 | Integrin alpha-4 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.814 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.807 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.715 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.863 | | P13612 | ITGA4 | Integrin alpha-4 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.818 | | Q13547 | HDAC1 | Histone deacetylase 1 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.772 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.842 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.762 | | P13612 | ITGA4 | Integrin alpha-4 | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.729 | | Q13547 | HDAC1 | Histone deacetylase 1 | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.735 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.913 | | P13612 | ITGA4 | Integrin alpha-4 | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.772 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.714 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.853 | | P13612 | ITGA4 | Integrin alpha-4 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.772 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.714 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.853 |
| | Ambrisentan | hsa04657 | IL-17 signaling pathway | 2.05E-03 | 7 | O00463, Q16539, P49841, P09341, P14780, P80188, P01375 | TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF | More | | | Ambrisentan | hsa04658 | Th1 and Th2 cell differentiation | 2.35E-12 | 14 | Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761 | PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| P14780 | MMP9 | Matrix metalloproteinase-9 | Q04759 | PRKCQ | Protein kinase C theta type | -0.787 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q04759 | PRKCQ | Protein kinase C theta type | 0.776 | | P51955 | NEK2 | Serine/threonine-protein kinase Nek2 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.779 | | P13612 | ITGA4 | Integrin alpha-4 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.729 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.745 | | P13612 | ITGA4 | Integrin alpha-4 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.768 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.74 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.719 | | P13612 | ITGA4 | Integrin alpha-4 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.85 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.744 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P51955 | NEK2 | Serine/threonine-protein kinase Nek2 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.785 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P51955 | NEK2 | Serine/threonine-protein kinase Nek2 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.827 | | P13612 | ITGA4 | Integrin alpha-4 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.732 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P51955 | NEK2 | Serine/threonine-protein kinase Nek2 | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | -0.723 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.861 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | 0.742 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.747 | | P13612 | ITGA4 | Integrin alpha-4 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.764 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.85 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.808 | | P13612 | ITGA4 | Integrin alpha-4 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.822 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.735 | | P51955 | NEK2 | Serine/threonine-protein kinase Nek2 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.788 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.714 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.795 | | P51955 | NEK2 | Serine/threonine-protein kinase Nek2 | Q13761 | RUNX3 | Runt-related transcription factor 3 | -0.713 | | P13612 | ITGA4 | Integrin alpha-4 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.78 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.884 |
| | Ambrisentan | hsa04659 | Th17 cell differentiation | 8.08E-10 | 17 | P25963, Q04759, P19174, P06239, P42224, P14784, P13765, P14778, P40189, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963 | NFKBIA, PRKCQ, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL6ST, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q04759 | PRKCQ | Protein kinase C theta type | 0.776 | | P51955 | NEK2 | Serine/threonine-protein kinase Nek2 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.785 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.869 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | P51955 | NEK2 | Serine/threonine-protein kinase Nek2 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.827 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P51955 | NEK2 | Serine/threonine-protein kinase Nek2 | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | -0.723 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.783 | | P51955 | NEK2 | Serine/threonine-protein kinase Nek2 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.788 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.768 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.717 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.795 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.764 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.83 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.735 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.85 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | -0.77 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.711 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 1 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | | P51955 | NEK2 | Serine/threonine-protein kinase Nek2 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.779 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.838 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.744 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.74 |
| | Ambrisentan | hsa04660 | T cell receptor signaling pathway | 8.48E-10 | 17 | P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841 | TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | | P08246 | ELA2 | Neutrophil elastase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.701 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.767 | | P08246 | ELA2 | Neutrophil elastase | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.896 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 0.723 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q04759 | PRKCQ | Protein kinase C theta type | -0.787 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P08246 | ELA2 | Neutrophil elastase | Q04759 | PRKCQ | Protein kinase C theta type | -0.748 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q04759 | PRKCQ | Protein kinase C theta type | 0.776 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | P08246 | ELA2 | Neutrophil elastase | P10747 | CD28 | T-cell-specific surface glycoprotein CD28 | -0.854 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P10747 | CD28 | T-cell-specific surface glycoprotein CD28 | 0.794 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.792 | | P13612 | ITGA4 | Integrin alpha-4 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | 0.834 | | P08246 | ELA2 | Neutrophil elastase | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.724 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.716 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.855 | | P13612 | ITGA4 | Integrin alpha-4 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.774 | | P08246 | ELA2 | Neutrophil elastase | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.782 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.746 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.746 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P13612 | ITGA4 | Integrin alpha-4 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.729 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.745 | | P13612 | ITGA4 | Integrin alpha-4 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.768 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.722 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.74 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.719 | | P13612 | ITGA4 | Integrin alpha-4 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.85 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.77 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.744 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.742 | | P13612 | ITGA4 | Integrin alpha-4 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.7 | | Q13547 | HDAC1 | Histone deacetylase 1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.816 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.722 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.92 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.793 | | P13612 | ITGA4 | Integrin alpha-4 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.83 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.806 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.719 | | P13612 | ITGA4 | Integrin alpha-4 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.732 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.889 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.75 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.861 |
| | Ambrisentan | hsa04662 | B cell receptor signaling pathway | 9.03E-05 | 5 | P42338, P60033, P07948, P21854, Q8N149 | PIK3CB, CD81, LYN, CD72, LILRA2 | More | | | Ambrisentan | hsa04664 | Fc epsilon RI signaling pathway | 3.09E-06 | 8 | P01375, P04141, Q16539, P42338, Q9UQC2, P07948, P19174, P09917 | TNF, CSF2, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5 | More | | | Ambrisentan | hsa04666 | Fc gamma R-mediated phagocytosis | 2.08E-04 | 7 | O75015, P42338, P23528, P06396, O14494, P14598, P17252 | FCGR3B, PIK3CB, CFL1, GSN, PLPP1, NCF1, PRKCA | More | | | Ambrisentan | hsa04668 | TNF signaling pathway | 2.41E-04 | 11 | P01375, O00463, Q13489, Q16539, P25963, Q99941, P01584, P20749, Q13077, P14780, O95429 | TNF, TRAF5, BIRC3, MAPK14, NFKBIA, CREBL1, IL1B, BCL3, TRAF1, MMP9, BAG4 | More | | | Ambrisentan | hsa04670 | Leukocyte transendothelial migration | 4.20E-02 | 7 | P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681 | MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK | More | | | Ambrisentan | hsa04672 | Intestinal immune network for IgA production | 1.62E-02 | 3 | P29965, P10747, P13765 | CD40LG, CD28, HLA-DOB | More | | | Ambrisentan | hsa04710 | Circadian rhythm | 1.67E-02 | 2 | Q16526, Q9Y478 | CRY1, PRKAB1 | More | | | Ambrisentan | hsa04713 | Circadian entrainment | 2.79E-03 | 5 | P0DP23, P62873, P63218, P50151, P63092 | CALM1, GNB1, GNG5, GNG10, GNAS | More | | | Ambrisentan | hsa04720 | Long-term potentiation | 1.38E-02 | 3 | P16298, P51812, Q02750 | PPP3CB, RPS6KA3, MAP2K1 | More | | | Ambrisentan | hsa04723 | Retrograde endocannabinoid signaling | 2.91E-03 | 7 | Q14643, P17252, P48169, P62873, P22694, Q16539, Q16718 | ITPR1, PRKCA, GABRA4, GNB1, PRKACB, MAPK14, NDUFA5 | More | | | Ambrisentan | hsa04724 | Glutamatergic synapse | 1.28E-04 | 6 | P43003, P63092, P62873, P63218, P50151, P15104 | SLC1A3, GNAS, GNB1, GNG5, GNG10, GLUL | More | | | Ambrisentan | hsa04725 | Cholinergic synapse | 3.74E-02 | 3 | P22694, Q14643, P10415 | PRKACB, ITPR1, BCL2 | More | | | Ambrisentan | hsa04726 | Serotonergic synapse | 2.79E-03 | 5 | P63092, P62873, P63218, P50151, P09917 | GNAS, GNB1, GNG5, GNG10, ALOX5 | More | | | Ambrisentan | hsa04727 | GABAergic synapse | 4.18E-03 | 4 | P62873, P63218, P50151, P15104 | GNB1, GNG5, GNG10, GLUL | More | | | Ambrisentan | hsa04730 | Long-term depression | 7.22E-03 | 2 | Q14344, P07948 | GNA13, LYN | More | | | Ambrisentan | hsa04744 | Phototransduction | 2.97E-04 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | | Ambrisentan | hsa04750 | Inflammatory mediator regulation of TRP channels | 7.62E-04 | 8 | P14778, P01584, P51828, Q13557, P19174, P42338, P24723, Q04759 | IL1R1, IL1B, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQ | More | | | Ambrisentan | hsa04810 | Regulation of actin cytoskeleton | 2.68E-02 | 2 | P23229, Q14344 | ITGA6, GNA13 | More | | | Ambrisentan | hsa04911 | Insulin secretion | 1.48E-02 | 3 | P51828, Q99941, Q13557 | ADCY7, CREBL1, CAMK2D | More | | | Ambrisentan | hsa04912 | GnRH signaling pathway | 7.63E-04 | 7 | P17252, Q08828, Q16539, Q9Y6R4, Q14643, P0DP23, P22694 | PRKCA, ADCY1, MAPK14, MAP3K4, ITPR1, CALM1, PRKACB | More | | | Ambrisentan | hsa04913 | Ovarian steroidogenesis | 2.70E-03 | 3 | P42330, P22694, P06213 | AKR1C3, PRKACB, INSR | More | | | Ambrisentan | hsa04914 | Progesterone-mediated oocyte maturation | 2.97E-03 | 6 | Q17RY0, P42338, Q13370, P08238, P51812, Q02750 | CPEB4, PIK3CB, PDE3B, HSP90AB1, RPS6KA3, MAP2K1 | More | | | Ambrisentan | hsa04915 | Estrogen signaling pathway | 7.33E-04 | 8 | Q99941, Q08828, P51828, P07900, P0DMV8, P11142, P0DP23, Q15788 | CREBL1, ADCY1, ADCY7, HSP90AA1, HSPA1A, HSPA8, CALM1, NCOA1 | More | | | Ambrisentan | hsa04916 | Melanogenesis | 4.80E-02 | 4 | P0DP23, Q9UJU2, P17252, P04628 | CALM1, LEF1, PRKCA, WNT1 | More | | | Ambrisentan | hsa04919 | Thyroid hormone signaling pathway | 1.64E-02 | 4 | P19174, P42224, Q13547, P01106 | PLCG1, STAT1, HDAC1, MYC | More | | | Ambrisentan | hsa04920 | Adipocytokine signaling pathway | 5.84E-03 | 6 | P25963, P33121, Q9Y478, Q04759, Q96RR4, P01375 | NFKBIA, ACSL1, PRKAB1, PRKCQ, CAMKK2, TNF | More | | | Ambrisentan | hsa04922 | Glucagon signaling pathway | 4.23E-02 | 4 | P22694, P06737, Q12778, Q14643 | PRKACB, PYGL, FOXO1, ITPR1 | More | | | Ambrisentan | hsa04923 | Regulation of lipolysis in adipocytes | 4.24E-03 | 4 | P07550, P06213, P42338, Q9Y4H2 | ADRB2, INSR, PIK3CB, IRS2 | More | | | Ambrisentan | hsa04924 | Renin secretion | 1.20E-06 | 5 | P22694, P07550, Q14643, Q13370, P0DP23 | PRKACB, ADRB2, ITPR1, PDE3B, CALM1 | More | | | Ambrisentan | hsa04925 | Aldosterone synthesis and secretion | 5.19E-03 | 4 | Q99941, P51828, Q13557, P23634 | CREBL1, ADCY7, CAMK2D, ATP2B4 | More | | | Ambrisentan | hsa04927 | Cortisol synthesis and secretion | 2.72E-02 | 2 | Q14643, P22694 | ITPR1, PRKACB | More | | | Ambrisentan | hsa04928 | Parathyroid hormone synthesis, secretion and action | 1.70E-04 | 5 | Q14643, P22694, P23771, P17252, P10415 | ITPR1, PRKACB, GATA3, PRKCA, BCL2 | More | | | Ambrisentan | hsa04930 | Type II diabetes mellitus | 3.14E-02 | 1 | P06213 | INSR | More | | | Ambrisentan | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 3.21E-02 | 5 | P84022, Q13485, P42338, P49767, P19174 | SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1 | More | | | Ambrisentan | hsa04934 | Cushing syndrome | 5.32E-04 | 7 | Q14643, Q99941, P51828, P22694, O15169, Q13557, P04628 | ITPR1, CREBL1, ADCY7, PRKACB, AXIN1, CAMK2D, WNT1 | More | | | Ambrisentan | hsa04940 | Type I diabetes mellitus | 4.18E-02 | 3 | P10747, P13765, P01375 | CD28, HLA-DOB, TNF | More | | | Ambrisentan | hsa04960 | Aldosterone-regulated sodium reabsorption | 3.14E-02 | 1 | P06213 | INSR | More | | | Ambrisentan | hsa04962 | Vasopressin-regulated water reabsorption | 1.80E-02 | 2 | P62491, P46459 | RAB11A, NSF | More | | | Ambrisentan | hsa04964 | Proximal tubule bicarbonate reclamation | 4.48E-02 | 1 | P00918 | CA2 | More | | | Ambrisentan | hsa04966 | Collecting duct acid secretion | 4.48E-02 | 1 | P00918 | CA2 | More | | | Ambrisentan | hsa04970 | Salivary secretion | 1.55E-04 | 7 | P07550, Q08828, P22694, Q14643, P17252, P0DP23, P49913 | ADRB2, ADCY1, PRKACB, ITPR1, PRKCA, CALM1, CAMP | More | | | Ambrisentan | hsa04971 | Gastric acid secretion | 1.48E-02 | 3 | P51828, P15311, Q13557 | ADCY7, VIL2, CAMK2D | More | | | Ambrisentan | hsa04972 | Pancreatic secretion | 3.65E-02 | 2 | P63092, P61586 | GNAS, RHOA | More | | | Ambrisentan | hsa04973 | Carbohydrate digestion and absorption | 1.29E-02 | 2 | O43451, P42338 | MGAM, PIK3CB | More | | | Ambrisentan | hsa05010 | Alzheimer disease | 2.07E-02 | 7 | Q92542, P05496, P12074, O75460, P01584, O15169, P45880 | NCSTN, ATP5G1, COX6A1, ERN1, IL1B, AXIN1, VDAC2 | More | | | Ambrisentan | hsa05012 | Parkinson disease | 1.77E-02 | 6 | P60604, P19174, P0DP23, Q71U36, Q13509, P68371 | UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2C | More | | | Ambrisentan | hsa05020 | Prion disease | 1.81E-02 | 7 | P01584, P46531, P11142, P05496, P12074, P45880, Q99941 | IL1B, NOTCH1, HSPA8, ATP5G1, COX6A1, VDAC2, CREBL1 | More | | | Ambrisentan | hsa05032 | Morphine addiction | 2.84E-04 | 6 | P62873, P63218, P50151, Q13370, P48169, P63092 | GNB1, GNG5, GNG10, PDE3B, GABRA4, GNAS | More | | | Ambrisentan | hsa05034 | Alcoholism | 4.03E-05 | 8 | Q13547, P62879, Q9BTM1, Q93077, P62807, Q16778, O60814, P68431 | HDAC1, GNB2, H2AFJ, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Ambrisentan | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 7.88E-05 | 8 | P25963, Q13488, P09341, P19875, P19174, P25024, P25025, P07948 | NFKBIA, TCIRG1, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN | More | | | Ambrisentan | hsa05130 | Pathogenic Escherichia coli infection | 3.19E-02 | 6 | Q71U36, P16333, Q13509, P68371, Q14344, P25963 | TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIA | More | | | Ambrisentan | hsa05131 | Shigellosis | 3.34E-02 | 11 | P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32 | TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF | More | | | Ambrisentan | hsa05132 | Salmonella infection | 3.39E-04 | 16 | P51617, P25963, P01375, P08238, Q9UJU2, Q13489, P10415, O75369, Q96A32, O60603, Q9BQS8, Q13561, Q71U36, Q13509, P68371, P49754 | IRAK1, NFKBIA, TNF, HSP90AB1, LEF1, BIRC3, BCL2, FLNB, MYLPF, TLR2, FYCO1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41 | More | | | Ambrisentan | hsa05133 | Pertussis | 3.51E-02 | 1 | P0C0L4 | C4A | More | | | Ambrisentan | hsa05134 | Legionellosis | 1.49E-03 | 5 | P25963, P11215, P11142, P09341, P19875 | NFKBIA, ITGAM, HSPA8, CXCL1, CXCL2 | More | | | Ambrisentan | hsa05140 | Leishmaniasis | 3.90E-06 | 12 | P13612, O75015, P14598, P11215, P42224, P13765, O60603, P25963, P01375, Q16539, P51617, Q15080 | ITGA4, FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, MAPK14, IRAK1, NCF4 | More | | | Ambrisentan | hsa05144 | Malaria | 3.30E-02 | 4 | P60033, O60603, P35443, P26718 | CD81, TLR2, THBS4, KLRK1 | More | | | Ambrisentan | hsa05145 | Toxoplasmosis | 3.07E-02 | 7 | P51617, P25963, P01375, P10415, Q13489, P13765, O60603 | IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2 | More | | | Ambrisentan | hsa05146 | Amoebiasis | 7.41E-05 | 12 | P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311 | CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG | More | | | Ambrisentan | hsa05150 | Staphylococcus aureus infection | 2.68E-03 | 8 | P0C0L4, P21730, P21462, O75015, P13765, Q16581, P13646, P49913 | C4A, C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT13, CAMP | More | | | Ambrisentan | hsa05152 | Tuberculosis | 1.06E-06 | 13 | Q13488, P0DP23, O75015, P48382, O60603, P01375, P10415, P13765, P01568, P49913, Q9UDY8, Q16539, P51617 | TCIRG1, CALM1, FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, IFNA21, CAMP, MALT1, MAPK14, IRAK1 | More | | | Ambrisentan | hsa05161 | Hepatitis B | 2.33E-02 | 8 | P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765 | PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4 | More | | | Ambrisentan | hsa05163 | Human cytomegalovirus infection | 4.30E-06 | 18 | P01375, P30511, P25963, P62873, P63218, P50151, P0DP23, Q14344, P61586, P49841, P14778, P25025, Q16539, P63092, O00463, P30101, P61769, P01568 | TNF, HLA-F, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, RHOA, GSK3B, IL1R1, CXCR2, MAPK14, GNAS, TRAF5, PDIA3, B2M, IFNA21 | More | | | Ambrisentan | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 4.88E-06 | 14 | P01568, P42224, P25963, P62873, P62879, P63218, P50151, P19174, P16298, Q02750, P07948, P04141, P0DP23, P0CG47 | IFNA21, STAT1, NFKBIA, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, MAP2K1, LYN, CSF2, CALM1, UBB | More | | | Ambrisentan | hsa05168 | Herpes simplex virus 1 infection | 1.60E-03 | 12 | P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, P42338, Q13398, Q03923, O75820, Q9UDV6 | NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, PIK3CB, ZNF211, ZNF85, ZNF189, ZNF212 | More | | | Ambrisentan | hsa05169 | Epstein-Barr virus infection | 3.66E-02 | 5 | P01106, Q13547, Q13761, P42224, P07766 | MYC, HDAC1, RUNX3, STAT1, CD3E | More | | | Ambrisentan | hsa05170 | Human immunodeficiency virus 1 infection | 2.77E-08 | 26 | Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, P01375, Q05397, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P19174, P23528, P10415, Q13619, Q93034, Q9Y6Q5, P20333 | MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, TNF, PTK2, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, CFL1, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1B | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P11511 | CYP19A1 | Aromatase | Q02750 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | 0.783 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.82 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.777 | | P11511 | CYP19A1 | Aromatase | P62879 | GNB2 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 | 0.704 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.703 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.704 | | P11511 | CYP19A1 | Aromatase | P16298 | PPP3CB | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform | 0.706 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P0DP23 | CALM1 | Calmodulin-1 | 0.775 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P0DP23 | CALM1 | Calmodulin-1 | -0.772 | | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | | P11511 | CYP19A1 | Aromatase | Q05397 | PTK2 | Focal adhesion kinase 1 | 0.75 | | P08246 | ELA2 | Neutrophil elastase | P17252 | PRKCA | Protein kinase C alpha type | -0.735 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P17252 | PRKCA | Protein kinase C alpha type | 0.844 | | P08246 | ELA2 | Neutrophil elastase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.814 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.773 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P30101 | PDIA3 | Protein disulfide-isomerase A3 | 0.83 | | P08246 | ELA2 | Neutrophil elastase | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.816 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.858 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P01568 | IFNA21 | Interferon alpha-21 | -0.733 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P01568 | IFNA21 | Interferon alpha-21 | 0.721 | | P08246 | ELA2 | Neutrophil elastase | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | -0.734 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.807 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 | | P08246 | ELA2 | Neutrophil elastase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.701 | | P08246 | ELA2 | Neutrophil elastase | O60603 | TLR2 | Toll-like receptor 2 | 0.853 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O60603 | TLR2 | Toll-like receptor 2 | -0.884 | | P08246 | ELA2 | Neutrophil elastase | Q13315 | ATM | Serine-protein kinase ATM | -0.742 | | P08246 | ELA2 | Neutrophil elastase | O95067 | CCNB2 | G2/mitotic-specific cyclin-B2 | 0.711 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.869 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P23528 | CFL1 | Cofilin-1 | 0.741 | | P08246 | ELA2 | Neutrophil elastase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.942 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 1 | | P08246 | ELA2 | Neutrophil elastase | Q13619 | CUL4A | Cullin-4A | -0.707 | | P08246 | ELA2 | Neutrophil elastase | Q93034 | CUL5 | Cullin-5 | -0.744 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q93034 | CUL5 | Cullin-5 | 0.704 | | P08246 | ELA2 | Neutrophil elastase | Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | 0.811 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | -0.901 | | P11511 | CYP19A1 | Aromatase | P20333 | TNFRSF1B | Tumor necrosis factor receptor superfamily member 1B | -0.75 |
| | Ambrisentan | hsa05200 | Pathways in cancer | 2.03E-06 | 27 | Q13751, P17301, P42338, P08238, P42224, P25963, P19174, P43246, P84022, Q13485, P20585, Q13547, P14923, P30281, P49767, P43657, P62873, P62879, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P01568, P14784, P40189 | LAMB3, ITGA2, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, SMAD4, MSH3, HDAC1, JUP, CCND3, VEGFC, P2RY5, GNB1, GNB2, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IFNA21, IL2RB, IL6ST | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13751 | LAMB3 | Laminin subunit beta-3 | 0.844 | | P00374 | DHFR | Dihydrofolate reductase | P17301 | ITGA2 | Integrin alpha-2 | 0.784 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.711 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 1 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.783 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.869 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.87 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.816 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43246 | MSH2 | DNA mismatch repair protein Msh2 | -0.811 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | -0.77 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P20585 | MSH3 | DNA mismatch repair protein Msh3 | 0.825 | | P00374 | DHFR | Dihydrofolate reductase | P20585 | MSH3 | DNA mismatch repair protein Msh3 | 1 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.754 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P14923 | JUP | Junction plakoglobin | -0.735 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P30281 | CCND3 | G1/S-specific cyclin-D3 | 0.743 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | -0.735 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.82 | | P00374 | DHFR | Dihydrofolate reductase | P62879 | GNB2 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 | 0.721 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.703 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.704 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | -0.756 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | 0.87 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | | P29375 | JARID1A | Lysine-specific demethylase 5A | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.748 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.742 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | 0.731 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P0DP23 | CALM1 | Calmodulin-1 | 0.755 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P0DP23 | CALM1 | Calmodulin-1 | 0.775 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P01568 | IFNA21 | Interferon alpha-21 | -0.733 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.768 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.717 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.83 |
| | Ambrisentan | hsa05202 | Transcriptional misregulation in cancer | 4.49E-10 | 20 | Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522 | FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45A | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P22894 | MMP8 | Neutrophil collagenase | Q12778 | FOXO1 | Forkhead box protein O1 | -0.72 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q12778 | FOXO1 | Forkhead box protein O1 | -0.769 | | P08246 | ELA2 | Neutrophil elastase | Q12778 | FOXO1 | Forkhead box protein O1 | -0.75 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q12778 | FOXO1 | Forkhead box protein O1 | 0.794 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q12778 | FOXO1 | Forkhead box protein O1 | 0.795 | | P22894 | MMP8 | Neutrophil collagenase | Q15532 | SS18 | Protein SSXT | -0.867 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q15532 | SS18 | Protein SSXT | -0.803 | | P08246 | ELA2 | Neutrophil elastase | Q15532 | SS18 | Protein SSXT | -0.806 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q15532 | SS18 | Protein SSXT | 0.877 | | P08246 | ELA2 | Neutrophil elastase | Q13315 | ATM | Serine-protein kinase ATM | -0.742 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q13315 | ATM | Serine-protein kinase ATM | 0.723 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P41732 | TSPAN7 | Tetraspanin-7 | 0.775 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P14780 | MMP9 | Matrix metalloproteinase-9 | 1 | | P22894 | MMP8 | Neutrophil collagenase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.882 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.861 | | P08246 | ELA2 | Neutrophil elastase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.859 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.765 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.746 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.851 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.734 | | P22894 | MMP8 | Neutrophil collagenase | P14923 | JUP | Junction plakoglobin | -0.809 | | P08246 | ELA2 | Neutrophil elastase | P14923 | JUP | Junction plakoglobin | -0.811 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P14923 | JUP | Junction plakoglobin | 0.861 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | 0.7 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.921 | | P22894 | MMP8 | Neutrophil collagenase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.843 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.837 | | P08246 | ELA2 | Neutrophil elastase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.766 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | -0.746 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | -0.701 | | P22894 | MMP8 | Neutrophil collagenase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.765 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.797 | | P08246 | ELA2 | Neutrophil elastase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.716 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.848 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.758 | | P22894 | MMP8 | Neutrophil collagenase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.806 | | P08246 | ELA2 | Neutrophil elastase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.725 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | 0.816 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | O15550 | UTX | Lysine-specific demethylase 6A | 0.789 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | O15550 | UTX | Lysine-specific demethylase 6A | -0.778 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | | P22894 | MMP8 | Neutrophil collagenase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.821 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.779 | | P08246 | ELA2 | Neutrophil elastase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.824 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.78 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | | P22894 | MMP8 | Neutrophil collagenase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.821 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.779 | | P08246 | ELA2 | Neutrophil elastase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.824 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.78 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P05164 | MPO | Myeloperoxidase | 0.812 | | P22894 | MMP8 | Neutrophil collagenase | P05164 | MPO | Myeloperoxidase | 0.905 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P05164 | MPO | Myeloperoxidase | 0.805 | | P08246 | ELA2 | Neutrophil elastase | P05164 | MPO | Myeloperoxidase | 0.903 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P05164 | MPO | Myeloperoxidase | -0.81 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P05164 | MPO | Myeloperoxidase | -0.866 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P12838 | DEFA4 | Neutrophil defensin 4 | 0.858 | | P08246 | ELA2 | Neutrophil elastase | P12838 | DEFA4 | Neutrophil defensin 4 | 0.709 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08246 | ELA2 | Neutrophil elastase | 0.859 | | P22894 | MMP8 | Neutrophil collagenase | P08246 | ELA2 | Neutrophil elastase | 0.985 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P08246 | ELA2 | Neutrophil elastase | 0.846 | | P08246 | ELA2 | Neutrophil elastase | P08246 | ELA2 | Neutrophil elastase | 1 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P08246 | ELA2 | Neutrophil elastase | -0.942 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P08246 | ELA2 | Neutrophil elastase | -0.76 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.752 | | P22894 | MMP8 | Neutrophil collagenase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.778 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.808 | | P08246 | ELA2 | Neutrophil elastase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.75 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.766 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.879 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P41182 | BCL6 | B-cell lymphoma 6 protein | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P12980 | LYL1 | Protein lyl-1 | 0.716 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.765 | | P22894 | MMP8 | Neutrophil collagenase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.766 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.764 | | P08246 | ELA2 | Neutrophil elastase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.7 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.734 |
| | Ambrisentan | hsa05203 | Viral carcinogenesis | 1.29E-03 | 7 | Q13547, Q15283, P12814, P06493, P62807, Q16778, O60814 | HDAC1, RASA2, ACTN1, CDK1, HIST1H2BC, HIST2H2BE, H2BC12 | More | | | Ambrisentan | hsa05204 | Chemical carcinogenesis | 1.48E-02 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Ambrisentan | hsa05205 | Proteoglycans in cancer | 1.09E-02 | 10 | Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P04628, Q13635, P08962 | TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, WNT1, PTCH1, CD63 | More | | | Ambrisentan | hsa05206 | MicroRNAs in cancer | 2.97E-03 | 6 | P15311, P21860, P61978, P46531, P63279, P22105 | VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB | More | | | Ambrisentan | hsa05212 | Pancreatic cancer | 2.74E-04 | 5 | P42338, P42224, P84022, Q13485, O75293 | PIK3CB, STAT1, SMAD3, SMAD4, GADD45B | More | | | Ambrisentan | hsa05213 | Endometrial cancer | 3.79E-02 | 2 | O15169, Q02750 | AXIN1, MAP2K1 | More | | | Ambrisentan | hsa05214 | Glioma | 2.11E-03 | 4 | P0DP23, P42338, P19174, O75293 | CALM1, PIK3CB, PLCG1, GADD45B | More | | | Ambrisentan | hsa05220 | Chronic myeloid leukemia | 2.16E-02 | 5 | Q13547, Q13485, P84022, P42338, O75293 | HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B | More | | | Ambrisentan | hsa05222 | Small cell lung cancer | 2.79E-02 | 6 | Q13489, P10415, P25963, Q13077, O00463, P24522 | BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A | More | | | Ambrisentan | hsa05226 | Gastric cancer | 3.79E-02 | 2 | Q02750, O15169 | MAP2K1, AXIN1 | More | | | Ambrisentan | hsa05231 | Choline metabolism in cancer | 1.39E-02 | 3 | Q9Y259, P19174, P49619 | CHKB, PLCG1, DGKG | More | | | Ambrisentan | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 6.20E-06 | 11 | P42338, P19174, P07766, P20963, P09693, P06239, P42224, O60603, P10747, Q04759, Q9HC35 | PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, CD28, PRKCQ, EML4 | More | | | Ambrisentan | hsa05310 | Asthma | 1.53E-04 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | | Ambrisentan | hsa05320 | Autoimmune thyroid disease | 8.64E-03 | 4 | P13765, P29965, P01568, P10747 | HLA-DOB, CD40LG, IFNA21, CD28 | More | | | Ambrisentan | hsa05321 | Inflammatory bowel disease | 3.35E-09 | 6 | O60603, P01375, P13765, Q14765, Q9UL17, P23771 | TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3 | More | | | Ambrisentan | hsa05322 | Systemic lupus erythematosus | 2.82E-06 | 15 | O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P12814, P05455 | FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1, SSB | More | | | Ambrisentan | hsa05323 | Rheumatoid arthritis | 1.60E-02 | 4 | P13765, P10747, P09341, O60603 | HLA-DOB, CD28, CXCL1, TLR2 | More | | | Ambrisentan | hsa05332 | Graft-versus-host disease | 4.00E-08 | 5 | P13765, P10747, P01375, P26715, Q13241 | HLA-DOB, CD28, TNF, KLRC1, KLRD1 | More | | | Ambrisentan | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 4.48E-02 | 1 | P54284 | CACNB3 | More | | | Ambrisentan | hsa05414 | Dilated cardiomyopathy | 4.55E-02 | 2 | P54284, P26678 | CACNB3, PLN | More | | | Ambrisentan | hsa05418 | Fluid shear stress and atherosclerosis | 1.40E-04 | 11 | Q16539, P42338, Q14145, P14598, P10599, P14780, P01375, P14778, P27930, P0DP23, P08238 | MAPK14, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, IL1R1, IL1R2, CALM1, HSP90AB1 | More | |
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