PharmaCoNets of Amantadine (SPCN: 39.80 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Amantadinehsa00190Oxidative phosphorylation5.12E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Amantadinehsa00220Arginine biosynthesis3.83E-022P05089, P49448ARG1, GLUD2More
Amantadinehsa00531Glycosaminoglycan degradation8.18E-042P15586, P34059GNS, GALNSMore
Amantadinehsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate2.92E-021Q9Y2C2USTMore
Amantadinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Amantadinehsa00830Retinol metabolism3.93E-023P00352, Q9BPW9, O75911ALDH1A1, DHRS9, DHRS3More
Amantadinehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Amantadinehsa03008Ribosome biogenesis in eukaryotes2.06E-022Q9NYH9, Q9BVP2UTP6, GNL3More
Amantadinehsa03015mRNA surveillance pathway2.95E-023O94913, Q9H307, Q13148PCF11, PNN, TARDBPMore
Amantadinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Amantadinehsa04020Calcium signaling pathway1.39E-024P30679, O15399, P07550, P23634GNA15, GRIN2D, ADRB2, ATP2B4More
Amantadinehsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Amantadinehsa04061Viral protein interaction with cytokine and cytokine receptor1.32E-026P09341, P25024, P47992, Q9UBD3, Q13651, P14784CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RBMore
Amantadinehsa04062Chemokine signaling pathway6.73E-039P25024, P09341, P47992, Q9UBD3, P07948, P63218, P50151, P43250, Q08881CXCR1, CXCL1, XCL1, XCL2, LYN, GNG5, GNG10, GRK6, ITKMore
Amantadinehsa04064NF-kappa B signaling pathway2.21E-0412Q13489, O00463, Q13546, P14778, Q04759, Q9UDY8, P07948, P06239, P24522, P09341, Q06643, Q9UNE0BIRC3, TRAF5, RIPK1, IL1R1, PRKCQ, MALT1, LYN, LCK, GADD45A, CXCL1, LTB, EDARMore
Amantadinehsa04120Ubiquitin mediated proteolysis3.42E-036Q14145, Q13042, P30260, Q13191, P62837, Q15751KEAP1, CDC16, CDC27, CBLB, UBE2D2, HERC1More
Amantadinehsa04142Lysosome1.14E-023P43234, P15586, P34059CTSO, GNS, GALNSMore
Amantadinehsa04210Apoptosis9.18E-034P04637, P24522, P43234, P63261TP53, GADD45A, CTSO, ACTG1More
Amantadinehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Amantadinehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Amantadinehsa04217Necroptosis2.34E-0513P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPIDMore
Amantadinehsa04612Antigen processing and presentation1.75E-026P13765, P01730, P26715, P26717, Q13241, P01732HLA-DOB, CD4, KLRC1, KLRC2, KLRD1, CD8AMore
Amantadinehsa04613Neutrophil extracellular trap formation3.76E-0410P11215, Q13547, P04908, Q93077, P58876, Q16778, O60814, P68431, O43315, Q16539ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Amantadinehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Amantadinehsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Amantadinehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Amantadinehsa04623Cytosolic DNA-sensing pathway2.63E-043P01568, Q13546, P25963IFNA21, RIPK1, NFKBIAMore
Amantadinehsa04640Hematopoietic cell lineage1.60E-0410P13612, P14778, P27930, P25063, P07766, P09693, P01732, P01730, P09564, P13765ITGA4, IL1R1, IL1R2, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOBMore
Amantadinehsa04650Natural killer cell mediated cytotoxicity3.08E-038P06239, O60880, P20963, Q13241, P26718, O14931, P26717, P26715LCK, SH2D1A, CD247, KLRD1, KLRK1, NCR3, KLRC2, KLRC1More
Amantadinehsa04658Th1 and Th2 cell differentiation2.44E-0711Q04759, P07766, P20963, P09693, P01730, P06239, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, CD4, LCK, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Amantadinehsa04659Th17 cell differentiation4.63E-0611Q04759, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Amantadinehsa04660T cell receptor signaling pathway8.91E-049Q04759, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239PRKCQ, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCKMore
Amantadinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Amantadinehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Amantadinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Amantadinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Amantadinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Amantadinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Amantadinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Amantadinehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Amantadinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Amantadinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Amantadinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Amantadinehsa05033Nicotine addiction1.22E-022P28472, O15399GABRB3, GRIN2DMore
Amantadinehsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Amantadinehsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Amantadinehsa05140Leishmaniasis1.56E-025P14598, P42224, P25963, P29350, Q15080NCF1, STAT1, NFKBIA, PTPN6, NCF4More
Amantadinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Amantadinehsa05146Amoebiasis9.73E-036P09341, P14778, P27930, P05089, P12814, P08311CXCL1, IL1R1, IL1R2, ARG1, ACTN1, CTSGMore
Amantadinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Amantadinehsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Amantadinehsa05169Epstein-Barr virus infection4.84E-0310P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247More
Amantadinehsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Amantadinehsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Amantadinehsa05205Proteoglycans in cancer4.43E-023P63261, P04637, Q06124ACTG1, TP53, PTPN11More
Amantadinehsa05211Renal cell carcinoma7.75E-032Q06124, Q99814PTPN11, EPAS1More
Amantadinehsa05212Pancreatic cancer2.60E-022P04637, P24522TP53, GADD45AMore
Amantadinehsa05213Endometrial cancer2.60E-022P04637, P24522TP53, GADD45AMore
Amantadinehsa05214Glioma2.60E-022P04637, P24522TP53, GADD45AMore
Amantadinehsa05216Thyroid cancer1.14E-022P04637, P24522TP53, GADD45AMore
Amantadinehsa05217Basal cell carcinoma2.06E-022P04637, P24522TP53, GADD45AMore
Amantadinehsa05218Melanoma1.14E-022P04637, P24522TP53, GADD45AMore
Amantadinehsa05220Chronic myeloid leukemia7.90E-033Q06124, P04637, P24522PTPN11, TP53, GADD45AMore
Amantadinehsa05223Non-small cell lung cancer3.19E-022P04637, P24522TP53, GADD45AMore
Amantadinehsa05224Breast cancer4.51E-022P04637, P24522TP53, GADD45AMore
Amantadinehsa05225Hepatocellular carcinoma3.30E-023P04637, P24522, P63261TP53, GADD45A, ACTG1More
Amantadinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer9.73E-036P07766, P20963, P09693, P06239, Q04759, P01730CD3E, CD247, CD3G, LCK, PRKCQ, CD4More
Amantadinehsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Amantadinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Amantadinehsa05332Graft-versus-host disease3.75E-035P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Amantadinehsa05340Primary immunodeficiency2.19E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Amantadinehsa05415Diabetic cardiomyopathy4.54E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore

Community members of Amantadine (SDC: 4.41)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P30679GNA15Guanine nucleotideNonebinding protein subunit alphaNone15Predicted00.03730.11460.28910.5369
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
Q9Y4K0LOXL2Lysyl oxidase homolog 2Predicted00.02690.119800.253
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)