PharmaCoNets of Alverine (SPCN: 116.55 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Alverinehsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Alverinehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Alverinehsa00190Oxidative phosphorylation4.83E-063Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Alverinehsa00230Purine metabolism1.81E-022P20839, Q02153IMPDH1, GUCY1B3More
Alverinehsa00260Glycine, serine and threonine metabolism1.99E-021P22557ALAS2More
Alverinehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Alverinehsa00565Ether lipid metabolism3.94E-021Q8N661TMEM86BMore
Alverinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Alverinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Alverinehsa00630Glyoxylate and dicarboxylate metabolism4.46E-032P40925, P15104MDH1, GLULMore
Alverinehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Alverinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Alverinehsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Alverinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Alverinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Alverinehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Alverinehsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Alverinehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P04049RAF1More
Alverinehsa01522Endocrine resistance2.16E-021P04049RAF1More
Alverinehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Alverinehsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Alverinehsa03013RNA transport9.49E-0714O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, P23588, Q9Y6A5, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, EIF4B, TACC3, FXR1More
Alverinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Alverinehsa03040Spliceosome2.96E-025O60508, P08579, Q07955, Q01130, Q9Y2W2CDC40, SNRPB2, SFRS1, SFRS2, WBP11More
Alverinehsa03050Proteasome1.21E-021P28074PSMB5More
Alverinehsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Alverinehsa04012ErbB signaling pathway1.82E-021P04049RAF1More
Alverinehsa04014Ras signaling pathway9.02E-036P04049, P42338, P20827, P49767, Q13009, P50151RAF1, PIK3CB, EFNA1, VEGFC, TIAM1, GNG10More
Alverinehsa04015Rap1 signaling pathway2.99E-021P04049RAF1More
Alverinehsa04022cGMP-PKG signaling pathway3.15E-021P04049RAF1More
Alverinehsa04024cAMP signaling pathway2.49E-021P04049RAF1More
Alverinehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Alverinehsa04062Chemokine signaling pathway7.67E-039P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151, P04049CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10, RAF1More
Alverinehsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Alverinehsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Alverinehsa04071Sphingolipid signaling pathway2.59E-038P04049, P17252, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2RAF1, PRKCA, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2More
Alverinehsa04072Phospholipase D signaling pathway2.31E-026P04049, P42338, P43657, P25024, P25025, P19174RAF1, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Alverinehsa04120Ubiquitin mediated proteolysis2.51E-036Q14145, Q13042, P62837, Q15751, O95071, P0CG47KEAP1, CDC16, UBE2D2, HERC1, UBR5, UBBMore
Alverinehsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Alverinehsa04137Mitophagy - animal9.52E-032Q07817, P0CG47BCL2L1, UBBMore
Alverinehsa04140Autophagy - animal2.82E-021P04049RAF1More
Alverinehsa04145Phagosome1.62E-049Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Alverinehsa04150mTOR signaling pathway2.32E-021P04049RAF1More
Alverinehsa04151PI3K-Akt signaling pathway1.14E-028P42338, P43657, P20827, P49767, P50151, O15335, Q13751, P14784PIK3CB, P2RY5, EFNA1, VEGFC, GNG10, CHAD, LAMB3, IL2RBMore
Alverinehsa04210Apoptosis3.64E-035O76075, P01375, Q9NR28, Q16548, P04049DFFB, TNF, DIABLO, BCL2A1, RAF1More
Alverinehsa04213Longevity regulating pathway - multiple species4.41E-034P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Alverinehsa04217Necroptosis2.24E-0412P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPIDMore
Alverinehsa04218Cellular senescence2.49E-021P04049RAF1More
Alverinehsa04270Vascular smooth muscle contraction2.32E-021P04049RAF1More
Alverinehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Alverinehsa04360Axon guidance2.49E-021P04049RAF1More
Alverinehsa04370VEGF signaling pathway8.29E-031P04049RAF1More
Alverinehsa04371Apelin signaling pathway2.65E-021P04049RAF1More
Alverinehsa04510Focal adhesion3.48E-021P04049RAF1More
Alverinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Alverinehsa04540Gap junction1.33E-021P04049RAF1More
Alverinehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P04049RAF1More
Alverinehsa04613Neutrophil extracellular trap formation1.62E-0612P04049, P11215, Q13547, P04908, Q93077, P58876, P62807, Q16778, O60814, P68431, O43315, Q16539RAF1, ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Alverinehsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Alverinehsa04625C-type lectin receptor signaling pathway1.49E-021P04049RAF1More
Alverinehsa04630JAK-STAT signaling pathway1.49E-021P04049RAF1More
Alverinehsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Alverinehsa04650Natural killer cell mediated cytotoxicity2.00E-049P19174, P06239, O60880, P20963, P42338, P04049, Q13241, P26718, O14931PLCG1, LCK, SH2D1A, CD247, PIK3CB, RAF1, KLRD1, KLRK1, NCR3More
Alverinehsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Alverinehsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Alverinehsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Alverinehsa04660T cell receptor signaling pathway2.00E-049Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239, P04049PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCK, RAF1More
Alverinehsa04662B cell receptor signaling pathway4.78E-056P42338, P60033, P07948, P21854, Q8N149, P04049PIK3CB, CD81, LYN, CD72, LILRA2, RAF1More
Alverinehsa04664Fc epsilon RI signaling pathway2.62E-034P42338, P07948, P04049, P09917PIK3CB, LYN, RAF1, ALOX5More
Alverinehsa04666Fc gamma R-mediated phagocytosis2.64E-026P04049, P23528, P06396, O14494, P14598, P17252RAF1, CFL1, GSN, PLPP1, NCF1, PRKCAMore
Alverinehsa04672Intestinal immune network for IgA production1.62E-023P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Alverinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Alverinehsa04720Long-term potentiation1.66E-021P04049RAF1More
Alverinehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Alverinehsa04722Neurotrophin signaling pathway7.10E-034P04049, P49841, O43524, P48023RAF1, GSK3B, FOXO3, FASLGMore
Alverinehsa04724Glutamatergic synapse3.24E-023P43003, P50151, P15104SLC1A3, GNG10, GLULMore
Alverinehsa04726Serotonergic synapse1.33E-021P04049RAF1More
Alverinehsa04730Long-term depression1.16E-021P04049RAF1More
Alverinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Alverinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Alverinehsa04744Phototransduction2.80E-022P62873, P0DP23GNB1, CALM1More
Alverinehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Alverinehsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Alverinehsa04910Insulin signaling pathway2.51E-034P22694, P06737, P04049, P49841PRKACB, PYGL, RAF1, GSK3BMore
Alverinehsa04912GnRH signaling pathway1.82E-021P04049RAF1More
Alverinehsa04914Progesterone-mediated oocyte maturation2.16E-021P04049RAF1More
Alverinehsa04915Estrogen signaling pathway2.99E-021P04049RAF1More
Alverinehsa04916Melanogenesis1.79E-025P0DP23, Q9UJU2, P17252, P04628, P04049CALM1, LEF1, PRKCA, WNT1, RAF1More
Alverinehsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Alverinehsa04919Thyroid hormone signaling pathway6.83E-045P49841, P04049, P22694, O60244, Q9NVC6GSK3B, RAF1, PRKACB, MED14, MED17More
Alverinehsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Alverinehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Alverinehsa04926Relaxin signaling pathway2.32E-021P04049RAF1More
Alverinehsa04928Parathyroid hormone synthesis, secretion and action1.99E-021P04049RAF1More
Alverinehsa04929GnRH secretion4.98E-031P04049RAF1More
Alverinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Alverinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Alverinehsa04935Growth hormone synthesis, secretion and action2.16E-021P04049RAF1More
Alverinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Alverinehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Alverinehsa04976Bile secretion1.67E-033O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Alverinehsa05017Spinocerebellar ataxia2.43E-021P28074PSMB5More
Alverinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Alverinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Alverinehsa05034Alcoholism1.81E-068Q13547, P04049, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, RAF1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Alverinehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Alverinehsa05132Salmonella infection2.89E-0211P51617, P04049, Q9UJU2, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371IRAK1, RAF1, LEF1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Alverinehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Alverinehsa05140Leishmaniasis5.18E-046P14598, P42224, O60603, P25963, P29350, Q15080NCF1, STAT1, TLR2, NFKBIA, PTPN6, NCF4More
Alverinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Alverinehsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Alverinehsa05152Tuberculosis9.25E-0310P04049, Q13488, P0DP23, P48382, O60603, P10415, P13765, P01568, Q9UDY8, P51617RAF1, TCIRG1, CALM1, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1More
Alverinehsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Alverinehsa05161Hepatitis B1.99E-021P04049RAF1More
Alverinehsa05163Human cytomegalovirus infection4.98E-021P04049RAF1More
Alverinehsa05164Influenza A3.65E-021P04049RAF1More
Alverinehsa05167Kaposi sarcoma-associated herpesvirus infection3.15E-021P04049RAF1More
Alverinehsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Alverinehsa05170Human immunodeficiency virus 1 infection1.35E-0313P04049, P62873, P0DP23, P17252, O00463, Q14643, P01568, P51617, O60603, P23528, P10415, Q93034, Q9Y6Q5RAF1, GNB1, CALM1, PRKCA, TRAF5, ITPR1, IFNA21, IRAK1, TLR2, CFL1, BCL2, CUL5, AP1M2More
Alverinehsa05202Transcriptional misregulation in cancer4.29E-0315Q12778, Q15532, P14780, P27930, P14923, Q16548, P11215, Q13489, Q13077, P35226, P05164, P08246, Q9C0K0, Q13547, P12980FOXO1, SS18, MMP9, IL1R2, JUP, BCL2A1, ITGAM, BIRC3, TRAF1, BMI1, MPO, ELA2, BCL11B, HDAC1, LYL1More
Alverinehsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Alverinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Alverinehsa05205Proteoglycans in cancer4.93E-0311Q13009, Q12955, Q14643, O75369, P04049, P14780, P17252, O60603, P04628, Q13635, P08962TIAM1, ANK3, ITPR1, FLNB, RAF1, MMP9, PRKCA, TLR2, WNT1, PTCH1, CD63More
Alverinehsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Alverinehsa05210Colorectal cancer1.66E-021P04049RAF1More
Alverinehsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Alverinehsa05212Pancreatic cancer1.16E-021P04049RAF1More
Alverinehsa05213Endometrial cancer9.95E-031P04049RAF1More
Alverinehsa05214Glioma9.95E-031P04049RAF1More
Alverinehsa05215Prostate cancer1.33E-021P04049RAF1More
Alverinehsa05218Melanoma6.63E-031P04049RAF1More
Alverinehsa05219Bladder cancer4.98E-031P04049RAF1More
Alverinehsa05220Chronic myeloid leukemia9.95E-031P04049RAF1More
Alverinehsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Alverinehsa05223Non-small cell lung cancer6.63E-031P04049RAF1More
Alverinehsa05224Breast cancer1.49E-021P04049RAF1More
Alverinehsa05225Hepatocellular carcinoma1.33E-021P04049RAF1More
Alverinehsa05226Gastric cancer8.29E-031P04049RAF1More
Alverinehsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Alverinehsa05231Choline metabolism in cancer1.33E-021P04049RAF1More
Alverinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.23E-037P42338, P19174, P07766, P20963, P06239, P04049, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, RAF1, PRKCQMore
Alverinehsa05320Autoimmune thyroid disease8.64E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Alverinehsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Alverinehsa05323Rheumatoid arthritis2.00E-023Q13488, P10747, O60603TCIRG1, CD28, TLR2More
Alverinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Alverinehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Alverinehsa05415Diabetic cardiomyopathy4.54E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore

Community members of Alverine (SDC: 6.44)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
P12271RLBP1RetinaldehydeNonebinding protein 1Predicted00.0840.106200.2543
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
Q07817BCL2L1BclNone2Nonelike protein 1Predicted10.08720.434911.9134
P35610SOAT1Sterol ONoneacyltransferase 1Predicted10.38550.29360.01650.7964
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)