PharmaCoNets

PharmaCoNets of Aluminum-acetate (S_PCN: 5.50 )

Aluminum-acetate regulated-network (S_DN: 9.65)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Aluminum-acetate

hsa00030

Pentose phosphate pathway

5.07E-03

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Aluminum-acetate

hsa00220

Arginine biosynthesis

1.54E-02

P05089, P49448

ARG1, GLUD2

Aluminum-acetate

hsa00500

Starch and sucrose metabolism

3.86E-02

O43451, P46976, P06737

MGAM, GYG1, PYGL

Aluminum-acetate

hsa00630

Glyoxylate and dicarboxylate metabolism

1.29E-02

P40925, P15104

MDH1, GLUL

Aluminum-acetate

hsa00910

Nitrogen metabolism

2.93E-02

P22748, P49448

CA4, GLUD2

Aluminum-acetate

hsa00970

Aminoacyl-tRNA biosynthesis

5.32E-03

O95363, P54136, Q15046

FARS2, RARS1, KARS

Aluminum-acetate

hsa00983

Drug metabolism - other enzymes

2.16E-03

P04183, P32320, P05164

TK1, CDA, MPO

Aluminum-acetate

hsa01522

Endocrine resistance

3.67E-02

P14780, P22694, Q9UM47, P46527, P10415

MMP9, PRKACB, NOTCH3, CDKN1B, BCL2

Aluminum-acetate

hsa03013

RNA transport

5.57E-03

P52298, Q09161, O14893, P37198, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5, Q06787

NCBP2, NCBP1, GEMIN2, NUP62, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3, FMR1

Aluminum-acetate

hsa03015

mRNA surveillance pathway

3.71E-02

O43148, Q13362, O94913, Q12996, Q09161, P52298

RNMT, PPP2R5C, PCF11, CSTF3, NCBP1, NCBP2

Aluminum-acetate

hsa04060

Cytokine-cytokine receptor interaction

1.74E-04

P14784, P27930, P14778, P08476, P26842, Q06643, Q13651, Q9HBE5, P25024, Q9UBD3, P47992, P01375, P09341, P19875, P18510, P01730, Q93038

IL2RB, IL1R2, IL1R1, INHBA, CD27, LTB, IL10RA, IL21R, CXCR1, XCL2, XCL1, TNF, CXCL1, CXCL2, IL1RN, CD4, TNFRSF25

Aluminum-acetate

hsa04061

Viral protein interaction with cytokine and cytokine receptor

3.36E-04

P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375

CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNF

Aluminum-acetate

hsa04062

Chemokine signaling pathway

5.37E-03

P25024, P09341, P19875, P07948, P42338, P19174, P63218, P50151, P43250

CXCR1, CXCL1, CXCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6

Aluminum-acetate

hsa04064

NF-kappa B signaling pathway

3.72E-09

P10415, Q13489, P25963, P51617, O00463, P14778, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q13315, P24522, O75293, P09341, P19875, Q06643

BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, ATM, GADD45A, GADD45B, CXCL1, CXCL2, LTB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24158	PRTN3	Myeloblastin	P10415	BCL2	Apoptosis regulator Bcl-2	-0.787
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P24158	PRTN3	Myeloblastin	O00463	TRAF5	TNF receptor-associated factor 5	-0.8
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P08311	CTSG	Cathepsin G	O00463	TRAF5	TNF receptor-associated factor 5	-0.853
P51124	GZMM	Granzyme M	P14778	IL1R1	Interleukin-1 receptor type 1	-0.886
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
P24158	PRTN3	Myeloblastin	Q04759	PRKCQ	Protein kinase C theta type	-0.845
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P24158	PRTN3	Myeloblastin	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.733
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P24158	PRTN3	Myeloblastin	Q16548	BCL2A1	Bcl-2-related protein A1	0.802
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P08311	CTSG	Cathepsin G	Q16548	BCL2A1	Bcl-2-related protein A1	0.79
P51124	GZMM	Granzyme M	P07948	LYN	Tyrosine-protein kinase Lyn	-0.76
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08311	CTSG	Cathepsin G	Q13315	ATM	Serine-protein kinase ATM	-0.709
P24158	PRTN3	Myeloblastin	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.772
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P08311	CTSG	Cathepsin G	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.799
P51124	GZMM	Granzyme M	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.78
P24158	PRTN3	Myeloblastin	P09341	CXCL1	Growth-regulated alpha protein	0.751
P51124	GZMM	Granzyme M	P09341	CXCL1	Growth-regulated alpha protein	-0.733
P08311	CTSG	Cathepsin G	P09341	CXCL1	Growth-regulated alpha protein	0.877
P51124	GZMM	Granzyme M	P19875	CXCL2	C-X-C motif chemokine 2	-0.739
P51124	GZMM	Granzyme M	Q06643	LTB	Lymphotoxin-beta	0.811

Aluminum-acetate

hsa04071

Sphingolipid signaling pathway

6.37E-04

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2

Aluminum-acetate

hsa04080

Neuroactive ligand-receptor interaction

1.83E-04

P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581

CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1

Aluminum-acetate

hsa04115

p53 signaling pathway

3.57E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Aluminum-acetate

hsa04137

Mitophagy - animal

3.24E-02

Q96CV9, Q9H1Y0, P18848, O43524

OPTN, ATG5, ATF4, FOXO3

Aluminum-acetate

hsa04145

Phagosome

1.53E-03

Q15080, P14598, Q13509, Q13488, P05164, P78380, O60603, P35443, P13765

NCF4, NCF1, TUBB3, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOB

Aluminum-acetate

hsa04210

Apoptosis

1.09E-03

Q13315, P10415, Q13489, O76075, P25963, P01375, P24522, Q16548, Q13077, P43234, P18848, Q14643

ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, CTSO, ATF4, ITPR1

Aluminum-acetate

hsa04213

Longevity regulating pathway - multiple species

3.85E-02

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Aluminum-acetate

hsa04340

Hedgehog signaling pathway

4.63E-02

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Aluminum-acetate

hsa04612

Antigen processing and presentation

7.95E-06

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Aluminum-acetate

hsa04613

Neutrophil extracellular trap formation

8.65E-06

P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462

PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P24158	PRTN3	Myeloblastin	O60603	TLR2	Toll-like receptor 2	0.729
P02788	LTF	Lactotransferrin	O60603	TLR2	Toll-like receptor 2	0.722
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P24158	PRTN3	Myeloblastin	P05164	MPO	Myeloperoxidase	0.979
P02788	LTF	Lactotransferrin	P05164	MPO	Myeloperoxidase	0.723
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P24158	PRTN3	Myeloblastin	P08246	ELA2	Neutrophil elastase	0.894
P02788	LTF	Lactotransferrin	P08246	ELA2	Neutrophil elastase	0.881
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P24158	PRTN3	Myeloblastin	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.873
P02788	LTF	Lactotransferrin	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.753
P08246	ELA2	Neutrophil elastase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.889
P24158	PRTN3	Myeloblastin	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.713
P02788	LTF	Lactotransferrin	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.776
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P02788	LTF	Lactotransferrin	P14598	NCF1	Neutrophil cytosol factor 1	0.707
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P24158	PRTN3	Myeloblastin	Q15080	NCF4	Neutrophil cytosol factor 4	0.815
P02788	LTF	Lactotransferrin	Q15080	NCF4	Neutrophil cytosol factor 4	0.812
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P24158	PRTN3	Myeloblastin	P20160	AZU1	Azurocidin	0.942
P08246	ELA2	Neutrophil elastase	P20160	AZU1	Azurocidin	0.842
P24158	PRTN3	Myeloblastin	P08311	CTSG	Cathepsin G	0.914
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P02788	LTF	Lactotransferrin	P49913	CAMP	Cathelicidin antimicrobial peptide	0.924
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P02788	LTF	Lactotransferrin	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.72
P24158	PRTN3	Myeloblastin	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.738
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
P24158	PRTN3	Myeloblastin	P21462	FPR1	fMet-Leu-Phe receptor	0.73
P02788	LTF	Lactotransferrin	P21462	FPR1	fMet-Leu-Phe receptor	0.828
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85

Aluminum-acetate

hsa04621

NOD-like receptor signaling pathway

8.41E-05

Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P59665, P59666, P12838

ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4

Aluminum-acetate

hsa04640

Hematopoietic cell lineage

2.66E-04

P13612, P14778, P27930, P11215, P15144, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375

ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF

Aluminum-acetate

hsa04650

Natural killer cell mediated cytotoxicity

7.60E-07

P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O75015, P26717, P26715

PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P49863	GZMK	Granzyme K	P01375	TNF	Tumor necrosis factor	-0.8
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P49863	GZMK	Granzyme K	P06239	LCK	Tyrosine-protein kinase Lck	0.846
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P24158	PRTN3	Myeloblastin	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.816
P51124	GZMM	Granzyme M	O60880	SH2D1A	SH2 domain-containing protein 1A	0.743
P49863	GZMK	Granzyme K	O60880	SH2D1A	SH2 domain-containing protein 1A	0.899
P08311	CTSG	Cathepsin G	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.92
P24158	PRTN3	Myeloblastin	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.729
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
P49863	GZMK	Granzyme K	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.893
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P51124	GZMM	Granzyme M	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.834
P24158	PRTN3	Myeloblastin	Q13241	KLRD1	Natural killer cells antigen CD94	-0.732
P49863	GZMK	Granzyme K	Q13241	KLRD1	Natural killer cells antigen CD94	0.809
P08311	CTSG	Cathepsin G	Q13241	KLRD1	Natural killer cells antigen CD94	-0.812
P24158	PRTN3	Myeloblastin	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.76
P51124	GZMM	Granzyme M	P26718	KLRK1	NKG2-D type II integral membrane protein	0.713
P49863	GZMK	Granzyme K	P26718	KLRK1	NKG2-D type II integral membrane protein	0.96
P08311	CTSG	Cathepsin G	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.875
P49863	GZMK	Granzyme K	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.775
P24158	PRTN3	Myeloblastin	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.77
P49863	GZMK	Granzyme K	P26717	KLRC2	NKG2-C type II integral membrane protein	0.891
P08311	CTSG	Cathepsin G	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
P24158	PRTN3	Myeloblastin	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
P49863	GZMK	Granzyme K	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.891
P08311	CTSG	Cathepsin G	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867

Aluminum-acetate

hsa04657

IL-17 signaling pathway

4.03E-05

P25963, O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P06702

NFKBIA, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, S100A9

Aluminum-acetate

hsa04658

Th1 and Th2 cell differentiation

1.80E-10

Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49863	GZMK	Granzyme K	Q04759	PRKCQ	Protein kinase C theta type	0.874
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P51124	GZMM	Granzyme M	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.916
P49863	GZMK	Granzyme K	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.745
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
P49863	GZMK	Granzyme K	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.893
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P49863	GZMK	Granzyme K	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.786
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P49863	GZMK	Granzyme K	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.756
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
P51124	GZMM	Granzyme M	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P49863	GZMK	Granzyme K	P06239	LCK	Tyrosine-protein kinase Lck	0.846
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P49863	GZMK	Granzyme K	Q14765	STAT4	Signal transducer and activator of transcription 4	0.848
P08311	CTSG	Cathepsin G	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.81
P49863	GZMK	Granzyme K	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.768
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P51124	GZMM	Granzyme M	Q9UL17	TBX21	T-box transcription factor TBX21	0.755
P49863	GZMK	Granzyme K	Q9UL17	TBX21	T-box transcription factor TBX21	0.918
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P51124	GZMM	Granzyme M	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.887
P49863	GZMK	Granzyme K	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.882
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P51124	GZMM	Granzyme M	Q13761	RUNX3	Runt-related transcription factor 3	0.849
P49863	GZMK	Granzyme K	Q13761	RUNX3	Runt-related transcription factor 3	0.704

Aluminum-acetate

hsa04659

Th17 cell differentiation

9.49E-08

Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P07766, P09693, P20963

PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49863	GZMK	Granzyme K	Q04759	PRKCQ	Protein kinase C theta type	0.874
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P49863	GZMK	Granzyme K	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.756
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
P51124	GZMM	Granzyme M	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P49863	GZMK	Granzyme K	P06239	LCK	Tyrosine-protein kinase Lck	0.846
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P51124	GZMM	Granzyme M	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.887
P49863	GZMK	Granzyme K	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.882
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P51124	GZMM	Granzyme M	P14778	IL1R1	Interleukin-1 receptor type 1	-0.886
P49863	GZMK	Granzyme K	Q9HBE5	IL21R	Interleukin-21 receptor	0.722
P08311	CTSG	Cathepsin G	Q9HBE5	IL21R	Interleukin-21 receptor	-0.763
P51124	GZMM	Granzyme M	Q9UL17	TBX21	T-box transcription factor TBX21	0.755
P49863	GZMK	Granzyme K	Q9UL17	TBX21	T-box transcription factor TBX21	0.918
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P49863	GZMK	Granzyme K	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.768
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P51124	GZMM	Granzyme M	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.916
P49863	GZMK	Granzyme K	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.745
P49863	GZMK	Granzyme K	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.786
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
P49863	GZMK	Granzyme K	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.893
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888

Aluminum-acetate

hsa04660

T cell receptor signaling pathway

8.34E-08

P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49863	GZMK	Granzyme K	P01375	TNF	Tumor necrosis factor	-0.8
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P49863	GZMK	Granzyme K	Q04759	PRKCQ	Protein kinase C theta type	0.874
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P51124	GZMM	Granzyme M	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.834
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P49863	GZMK	Granzyme K	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.872
P08246	ELA2	Neutrophil elastase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.724
P08311	CTSG	Cathepsin G	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.705
P49863	GZMK	Granzyme K	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.952
P08246	ELA2	Neutrophil elastase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.782
P08311	CTSG	Cathepsin G	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
P51124	GZMM	Granzyme M	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.916
P49863	GZMK	Granzyme K	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.745
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
P49863	GZMK	Granzyme K	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.893
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P49863	GZMK	Granzyme K	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.786
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P51124	GZMM	Granzyme M	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P49863	GZMK	Granzyme K	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.784
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
P49863	GZMK	Granzyme K	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.793
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P49863	GZMK	Granzyme K	P06239	LCK	Tyrosine-protein kinase Lck	0.846
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P49863	GZMK	Granzyme K	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.756
P49863	GZMK	Granzyme K	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.716

Aluminum-acetate

hsa04662

B cell receptor signaling pathway

1.07E-02

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Aluminum-acetate

hsa04664

Fc epsilon RI signaling pathway

1.29E-02

P42338, P07948, P19174, P09917

PIK3CB, LYN, PLCG1, ALOX5

Aluminum-acetate

hsa04668

TNF signaling pathway

2.36E-03

P01375, O00463, Q13489, Q16539, P25963, P09341, P20749, Q13077, P14780

TNF, TRAF5, BIRC3, MAPK14, NFKBIA, CXCL1, BCL3, TRAF1, MMP9

Aluminum-acetate

hsa04670

Leukocyte transendothelial migration

4.20E-02

P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681

MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK

Aluminum-acetate

hsa04724

Glutamatergic synapse

2.81E-02

P43003, P63218, P50151, P15104

SLC1A3, GNG5, GNG10, GLUL

Aluminum-acetate

hsa04725

Cholinergic synapse

3.86E-02

P22694, Q14643, P18848, P10415

PRKACB, ITPR1, ATF4, BCL2

Aluminum-acetate

hsa04750

Inflammatory mediator regulation of TRP channels

4.06E-03

P14778, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759

IL1R1, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ

Aluminum-acetate

hsa04915

Estrogen signaling pathway

2.25E-02

P14780, P22694, P18848, Q14643, P10415

MMP9, PRKACB, ATF4, ITPR1, BCL2

Aluminum-acetate

hsa04918

Thyroid hormone synthesis

2.91E-02

P22694, P18848, Q14643

PRKACB, ATF4, ITPR1

Aluminum-acetate

hsa04920

Adipocytokine signaling pathway

4.49E-02

P25963, P33121, Q04759, P01375

NFKBIA, ACSL1, PRKCQ, TNF

Aluminum-acetate

hsa04927

Cortisol synthesis and secretion

7.04E-03

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Aluminum-acetate

hsa04928

Parathyroid hormone synthesis, secretion and action

1.60E-02

Q14643, P22694, P23771, P18848, P10415

ITPR1, PRKACB, GATA3, ATF4, BCL2

Aluminum-acetate

hsa04934

Cushing syndrome

4.06E-02

Q14643, P22694, P49841, Q9UJU2, O00170

ITPR1, PRKACB, GSK3B, LEF1, AIP

Aluminum-acetate

hsa04964

Proximal tubule bicarbonate reclamation

2.93E-02

P22748, P49448

CA4, GLUD2

Aluminum-acetate

hsa04970

Salivary secretion

4.49E-02

P22694, Q14643, P17252, P49913

PRKACB, ITPR1, PRKCA, CAMP

Aluminum-acetate

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Aluminum-acetate

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.78E-03

P09341, P19875, P19174, P25024, P07948

CXCL1, CXCL2, PLCG1, CXCR1, LYN

Aluminum-acetate

hsa05131

Shigellosis

3.34E-02

P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32

TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF

Aluminum-acetate

hsa05132

Salmonella infection

2.98E-02

P51617, P25963, P01375, Q9UJU2, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509

IRAK1, NFKBIA, TNF, LEF1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3

Aluminum-acetate

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Aluminum-acetate

hsa05135

Yersinia infection

4.26E-02

P13612, P06239, Q16539, P01375, P49841, P01732

ITGA4, LCK, MAPK14, TNF, GSK3B, CD8A

Aluminum-acetate

hsa05140

Leishmaniasis

7.32E-04

O75015, P14598, P13765, O60603, P25963, P01375, P29350, P51617, Q15080

FCGR3B, NCF1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, IRAK1, NCF4

Aluminum-acetate

hsa05144

Malaria

1.80E-02

O60603, P01375, P35443, P26718

TLR2, TNF, THBS4, KLRK1

Aluminum-acetate

hsa05145

Toxoplasmosis

3.07E-02

P51617, P25963, P01375, P10415, Q13489, P13765, O60603

IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2

Aluminum-acetate

hsa05146

Amoebiasis

1.05E-08

Q13751, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

LAMB3, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Aluminum-acetate

hsa05150

Staphylococcus aureus infection

3.71E-02

P21462, O75015, P59665, P59666, P12838, P49913

FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Aluminum-acetate

hsa05152

Tuberculosis

3.32E-04

Q13488, O75015, P48382, P25208, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617

TCIRG1, FCGR3B, RFX5, NFYB, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P02788	LTF	Lactotransferrin	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.701
P08246	ELA2	Neutrophil elastase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.71
P02788	LTF	Lactotransferrin	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.72
P24158	PRTN3	Myeloblastin	P48382	RFX5	DNA-binding protein RFX5	-0.87
P02788	LTF	Lactotransferrin	P48382	RFX5	DNA-binding protein RFX5	-0.846
P08246	ELA2	Neutrophil elastase	P48382	RFX5	DNA-binding protein RFX5	-0.895
P02788	LTF	Lactotransferrin	P25208	NFYB	Nuclear transcription factor Y subunit beta	-0.833
P24158	PRTN3	Myeloblastin	O60603	TLR2	Toll-like receptor 2	0.729
P02788	LTF	Lactotransferrin	O60603	TLR2	Toll-like receptor 2	0.722
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P02788	LTF	Lactotransferrin	P01375	TNF	Tumor necrosis factor	0.887
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P24158	PRTN3	Myeloblastin	P10415	BCL2	Apoptosis regulator Bcl-2	-0.787
P02788	LTF	Lactotransferrin	P10415	BCL2	Apoptosis regulator Bcl-2	-0.747
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P24158	PRTN3	Myeloblastin	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.796
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
P02788	LTF	Lactotransferrin	P49913	CAMP	Cathelicidin antimicrobial peptide	0.924
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P24158	PRTN3	Myeloblastin	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.733
P02788	LTF	Lactotransferrin	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.769
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734

Aluminum-acetate

hsa05161

Hepatitis B

2.33E-02

P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765

PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4

Aluminum-acetate

hsa05163

Human cytomegalovirus infection

2.64E-02

P42338, P63218, P50151, P01106, P14778, Q13651, P30101

PIK3CB, GNG5, GNG10, MYC, IL1R1, IL10RA, PDIA3

Aluminum-acetate

hsa05167

Kaposi sarcoma-associated herpesvirus infection

7.60E-03

P42338, P63218, P50151, P09341, P19875, P19174, P07948, P01106

PIK3CB, GNG5, GNG10, CXCL1, CXCL2, PLCG1, LYN, MYC

Aluminum-acetate

hsa05169

Epstein-Barr virus infection

1.27E-02

P01106, Q13547, P42338, P07948, P30101, Q13761, O75293, P07766, P20963

MYC, HDAC1, PIK3CB, LYN, PDIA3, RUNX3, GADD45B, CD3E, CD247

Aluminum-acetate

hsa05170

Human immunodeficiency virus 1 infection

1.21E-04

P42338, P63218, P50151, P01375, P17252, O00463, P30101, Q14643, P01730, P51617, P25963, O60603, Q13315, O95067, P19174, P07766, P20963, P10415, Q13619, Q93034, Q9Y6Q5

PIK3CB, GNG5, GNG10, TNF, PRKCA, TRAF5, PDIA3, ITPR1, CD4, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, CD3E, CD247, BCL2, CUL4A, CUL5, AP1M2

Aluminum-acetate

hsa05202

Transcriptional misregulation in cancer

1.77E-08

Q12778, Q15532, Q13315, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P46527, P35226, O60583, P05164, P59665, P59666, P12838, P08246, Q9C0K0, P24522

FOXO1, SS18, ATM, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, CDKN1B, BMI1, CCNT2, MPO, DEFA1; DEFA1B, DEFA3, DEFA4, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
P24158	PRTN3	Myeloblastin	Q15532	SS18	Protein SSXT	-0.732
P08246	ELA2	Neutrophil elastase	Q15532	SS18	Protein SSXT	-0.806
P02788	LTF	Lactotransferrin	Q13315	ATM	Serine-protein kinase ATM	-0.755
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08311	CTSG	Cathepsin G	Q13315	ATM	Serine-protein kinase ATM	-0.709
P24158	PRTN3	Myeloblastin	P14780	MMP9	Matrix metalloproteinase-9	0.837
P02788	LTF	Lactotransferrin	P14780	MMP9	Matrix metalloproteinase-9	0.82
P08246	ELA2	Neutrophil elastase	P14780	MMP9	Matrix metalloproteinase-9	0.859
P08311	CTSG	Cathepsin G	P14780	MMP9	Matrix metalloproteinase-9	0.79
P24158	PRTN3	Myeloblastin	P27930	IL1R2	Interleukin-1 receptor type 2	0.735
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
P08246	ELA2	Neutrophil elastase	P14923	JUP	Junction plakoglobin	-0.811
P24158	PRTN3	Myeloblastin	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.741
P08311	CTSG	Cathepsin G	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.909
P24158	PRTN3	Myeloblastin	Q16548	BCL2A1	Bcl-2-related protein A1	0.802
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P08311	CTSG	Cathepsin G	Q16548	BCL2A1	Bcl-2-related protein A1	0.79
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P24158	PRTN3	Myeloblastin	O15550	UTX	Lysine-specific demethylase 6A	0.776
P02788	LTF	Lactotransferrin	P46527	CDKN1B	Cyclin-dependent kinase inhibitor 1B	-0.721
P02788	LTF	Lactotransferrin	P35226	BMI1	Polycomb complex protein BMI-1	-0.897
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P02788	LTF	Lactotransferrin	P35226	BMI1	Polycomb complex protein BMI-1	-0.897
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P02788	LTF	Lactotransferrin	O60583	CCNT2	Cyclin-T2	-0.751
P24158	PRTN3	Myeloblastin	P05164	MPO	Myeloperoxidase	0.979
P02788	LTF	Lactotransferrin	P05164	MPO	Myeloperoxidase	0.723
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P08311	CTSG	Cathepsin G	P05164	MPO	Myeloperoxidase	0.956
P02788	LTF	Lactotransferrin	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.828
P02788	LTF	Lactotransferrin	P59666	DEFA3	Neutrophil defensin 3	0.828
P02788	LTF	Lactotransferrin	P12838	DEFA4	Neutrophil defensin 4	0.764
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709
P08311	CTSG	Cathepsin G	P12838	DEFA4	Neutrophil defensin 4	0.817
P24158	PRTN3	Myeloblastin	P08246	ELA2	Neutrophil elastase	0.894
P02788	LTF	Lactotransferrin	P08246	ELA2	Neutrophil elastase	0.881
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P08311	CTSG	Cathepsin G	P08246	ELA2	Neutrophil elastase	0.792
P24158	PRTN3	Myeloblastin	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.777
P08246	ELA2	Neutrophil elastase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.75
P08311	CTSG	Cathepsin G	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.853
P24158	PRTN3	Myeloblastin	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.772
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P08311	CTSG	Cathepsin G	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.799

Aluminum-acetate

hsa05217

Basal cell carcinoma

3.39E-02

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Aluminum-acetate

hsa05222

Small cell lung cancer

2.79E-02

Q13489, P10415, P25963, Q13077, O00463, P24522

BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A

Aluminum-acetate

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

6.30E-05

P42338, O95267, P19174, P07766, P20963, P09693, P06239, Q04759, Q16539, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PRKCQ, MAPK14, CD4

Aluminum-acetate

hsa05310

Asthma

6.41E-06

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Aluminum-acetate

hsa05321

Inflammatory bowel disease

3.94E-09

O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Aluminum-acetate

hsa05322

Systemic lupus erythematosus

4.90E-03

P08246, P08311, P01375, P10747, P13765, Q6FI13, Q16778, P12814, P05455

ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST2H2BE, ACTN1, SSB

Aluminum-acetate

hsa05323

Rheumatoid arthritis

2.72E-02

P01375, P13765, P09341, O60603

TNF, HLA-DOB, CXCL1, TLR2

Aluminum-acetate

hsa05332

Graft-versus-host disease

1.60E-06

P13765, P10747, P01375, P26715, Q13241

HLA-DOB, CD28, TNF, KLRC1, KLRD1

UniProtAC	Gene Name	Protein Name	Reported/ Predicted	DisGeNET	S_PV	S_drugability	S_HiSBiN	S_DisG

PharmaCoNets of Aluminum-acetate (SPCN: 5.50 )

Aluminum-acetate regulated-network (SDN: 9.65)

Community members of Aluminum-acetate (SDC: 0.57)

PharmaCoNets of Aluminum-acetate (S_PCN: 5.50 )

Aluminum-acetate regulated-network (S_DN: 9.65)

Community members of Aluminum-acetate (S_DC: 0.57)