PharmaCoNets of Alprostadil (SPCN: 2.84 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Alprostadilhsa00310Lysine degradation6.96E-032Q96KQ7, P51648EHMT2, ALDH3A2More
Alprostadilhsa00515Mannose type O-glycan biosynthesis4.96E-021O75072FCMDMore
Alprostadilhsa00620Pyruvate metabolism2.18E-022P40925, P51648MDH1, ALDH3A2More
Alprostadilhsa00630Glyoxylate and dicarboxylate metabolism2.40E-032P40925, P15104MDH1, GLULMore
Alprostadilhsa01524Platinum drug resistance1.13E-025P10415, Q13489, P78417, P23025, P43246BCL2, BIRC3, GSTO1, XPA, MSH2More
Alprostadilhsa03008Ribosome biogenesis in eukaryotes2.52E-023P78345, O15381, Q9GZY0RPP38, NVL, NXF2; NXF2BMore
Alprostadilhsa03013RNA transport7.27E-0312O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, Q14240, Q9Y6A5, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, EIF4A2, TACC3, FXR1More
Alprostadilhsa03040Spliceosome3.37E-0511Q14562, O43143, O60508, Q99633, P26368, Q13595, Q01130, Q13243, Q9UMS4, P11142, O43447DHX8, DHX15, CDC40, PRPF18, U2AF2, TRA2A, SFRS2, SFRS5, PRPF19, HSPA8, PPIHMore
Alprostadilhsa03450Non-homologous end-joining4.96E-021Q9NP87POLMMore
Alprostadilhsa04015Rap1 signaling pathway1.58E-026P20827, P49767, P63261, P25116, P0DP23, P17252EFNA1, VEGFC, ACTG1, F2R, CALM1, PRKCAMore
Alprostadilhsa04020Calcium signaling pathway1.16E-037Q16566, P17252, O15399, P25116, P0DP23, P23634, P49767CAMK4, PRKCA, GRIN2D, F2R, CALM1, ATP2B4, VEGFCMore
Alprostadilhsa04024cAMP signaling pathway2.84E-025P0DP23, P23634, Q16566, O15399, P25116CALM1, ATP2B4, CAMK4, GRIN2D, F2RMore
Alprostadilhsa04071Sphingolipid signaling pathway4.46E-048P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Alprostadilhsa04141Protein processing in endoplasmic reticulum1.41E-024P30101, P60604, P11142, P08238PDIA3, UBE2G2, HSPA8, HSP90AB1More
Alprostadilhsa04145Phagosome1.06E-0311O75015, P63261, Q15080, Q13509, P68371, Q13488, P05164, O60603, P35443, P27824, P13765FCGR3B, ACTG1, NCF4, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, CANX, HLA-DOBMore
Alprostadilhsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Alprostadilhsa04390Hippo signaling pathway1.47E-025P63261, Q13485, Q9UJU2, O43623, Q13489ACTG1, SMAD4, LEF1, SNAI2, BIRC3More
Alprostadilhsa04510Focal adhesion3.21E-026Q15942, P17252, Q13489, P10415, P49767, P63261ZYX, PRKCA, BIRC3, BCL2, VEGFC, ACTG1More
Alprostadilhsa04520Adherens junction3.36E-024Q13485, Q9UJU2, O43623, P63261SMAD4, LEF1, SNAI2, ACTG1More
Alprostadilhsa04540Gap junction4.76E-023P17252, Q13509, P68371PRKCA, TUBB3, TUBB2CMore
Alprostadilhsa04613Neutrophil extracellular trap formation1.05E-0212P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Alprostadilhsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Alprostadilhsa04720Long-term potentiation2.74E-034P17252, Q16566, P0DP23, O15399PRKCA, CAMK4, CALM1, GRIN2DMore
Alprostadilhsa04723Retrograde endocannabinoid signaling1.75E-025Q14643, P17252, P22694, Q16539, Q16718ITPR1, PRKCA, PRKACB, MAPK14, NDUFA5More
Alprostadilhsa04730Long-term depression1.35E-022Q14344, P07948GNA13, LYNMore
Alprostadilhsa04912GnRH signaling pathway3.14E-035P17252, Q16539, Q9Y6R4, Q14643, P22694PRKCA, MAPK14, MAP3K4, ITPR1, PRKACBMore
Alprostadilhsa04916Melanogenesis3.55E-023P0DP23, Q9UJU2, P17252CALM1, LEF1, PRKCAMore
Alprostadilhsa04921Oxytocin signaling pathway4.19E-024P0DP23, P17252, Q16566, P63261CALM1, PRKCA, CAMK4, ACTG1More
Alprostadilhsa04925Aldosterone synthesis and secretion7.20E-034P0DP23, P17252, Q16566, P23634CALM1, PRKCA, CAMK4, ATP2B4More
Alprostadilhsa04928Parathyroid hormone synthesis, secretion and action3.75E-025Q14643, P22694, P23771, P17252, P10415ITPR1, PRKACB, GATA3, PRKCA, BCL2More
Alprostadilhsa04933AGE-RAGE signaling pathway in diabetic complications3.36E-024Q13485, P10415, P49767, P17252SMAD4, BCL2, VEGFC, PRKCAMore
Alprostadilhsa04970Salivary secretion3.55E-023P23634, P17252, P0DP23ATP2B4, PRKCA, CALM1More
Alprostadilhsa04971Gastric acid secretion4.76E-023P17252, P63261, P0DP23PRKCA, ACTG1, CALM1More
Alprostadilhsa04978Mineral absorption3.94E-022P23634, Q9BXS9ATP2B4, SLC26A6More
Alprostadilhsa05012Parkinson disease2.31E-024P21796, P60604, Q71U36, Q13509VDAC1, UBE2G2, TUBA1A, TUBB3More
Alprostadilhsa05014Amyotrophic lateral sclerosis4.31E-027O15399, P10415, Q13509, P68371, Q53GS7, P63261, Q9GZY0GRIN2D, BCL2, TUBB3, TUBB2C, GLE1, ACTG1, NXF2; NXF2BMore
Alprostadilhsa05020Prion disease3.50E-024P11142, P21796, Q71U36, Q13509HSPA8, VDAC1, TUBA1A, TUBB3More
Alprostadilhsa05022Pathways of neurodegeneration - multiple diseases4.20E-025Q71U36, Q13509, P21796, P04628, P60604TUBA1A, TUBB3, VDAC1, WNT1, UBE2G2More
Alprostadilhsa05031Amphetamine addiction1.49E-024O15399, P0DP23, Q16566, P17252GRIN2D, CALM1, CAMK4, PRKCAMore
Alprostadilhsa05132Salmonella infection4.98E-026Q9UJU2, P63261, Q13489, P10415, Q13509, P68371LEF1, ACTG1, BIRC3, BCL2, TUBB3, TUBB2CMore
Alprostadilhsa05133Pertussis2.52E-023P0DP23, P23528, P09871CALM1, CFL1, C1SMore
Alprostadilhsa05152Tuberculosis1.26E-028Q13488, O75015, P48382, O60603, P10415, P13765, Q9UDY8, Q16539TCIRG1, FCGR3B, RFX5, TLR2, BCL2, HLA-DOB, MALT1, MAPK14More
Alprostadilhsa05168Herpes simplex virus 1 infection1.94E-029Q9UKJ0, P01568, Q9GZY0, Q01130, Q13489, Q13398, Q03923, Q9UDV6, P10415PILRB, IFNA21, NXF2; NXF2B, SFRS2, BIRC3, ZNF211, ZNF85, ZNF212, BCL2More
Alprostadilhsa05200Pathways in cancer1.51E-0212Q9UJU2, P17252, P43246, Q13485, P14923, P10415, Q13489, P49767, P25116, P78417, P0DP23, P01568LEF1, PRKCA, MSH2, SMAD4, JUP, BCL2, BIRC3, VEGFC, F2R, GSTO1, CALM1, IFNA21More
Alprostadilhsa05202Transcriptional misregulation in cancer2.48E-0313Q12778, Q15532, P41732, P14780, P27930, Q16548, Q13489, O15550, P35226, P05164, P08246, Q9C0K0, P24522FOXO1, SS18, TSPAN7, MMP9, IL1R2, BCL2A1, BIRC3, UTX, BMI1, MPO, ELA2, BCL11B, GADD45AMore
Alprostadilhsa05212Pancreatic cancer3.40E-021P37173TGFBR2More
Alprostadilhsa05214Glioma3.55E-023P0DP23, Q16566, P17252CALM1, CAMK4, PRKCAMore
Alprostadilhsa05321Inflammatory bowel disease3.69E-024O60603, P13765, Q14765, P23771TLR2, HLA-DOB, STAT4, GATA3More
Alprostadilhsa05332Graft-versus-host disease1.32E-024P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More
Alprostadilhsa05418Fluid shear stress and atherosclerosis2.31E-025P78417, P63261, P10415, P0DP23, Q92974GSTO1, ACTG1, BCL2, CALM1, ARHGEF2More

Community members of Alprostadil (SDC: 0.44)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
P46091GPR1ChemerinNonelike receptor 2Predicted00.24760.137200.3982
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
Q15722LTB4RLeukotriene B4 receptor 1Predicted00.06770.219900.4736
O15529GPR42GNoneprotein coupled receptor 42Predicted10.01270.016200.0388
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)