PharmaCoNets of Alprazolam (SPCN: 311.40 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Alprazolamhsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Alprazolamhsa00030Pentose phosphate pathway6.22E-042P60891, P37837PRPS1, TALDO1More
Alprazolamhsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Alprazolamhsa00051Fructose and mannose metabolism3.92E-033P15121, P19367, P08237AKR1B1, HK1, PFKMMore
Alprazolamhsa00052Galactose metabolism8.55E-065P06280, P08237, O43451, P15121, P19367GLA, PFKM, MGAM, AKR1B1, HK1More
Alprazolamhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Alprazolamhsa00190Oxidative phosphorylation8.07E-093Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Alprazolamhsa00220Arginine biosynthesis8.90E-073P15104, P05089, P49448GLUL, ARG1, GLUD2More
Alprazolamhsa00230Purine metabolism4.02E-022P31350, P21589RRM2, NT5EMore
Alprazolamhsa00240Pyrimidine metabolism2.54E-043P31350, P21589, P04818RRM2, NT5E, TYMSMore
Alprazolamhsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Alprazolamhsa00280Valine, leucine and isoleucine degradation2.03E-035P55809, Q9HCC0, P26440, Q02252, P11310OXCT1, MCCC2, IVD, ALDH6A1, ACADMMore
Alprazolamhsa00330Arginine and proline metabolism4.86E-021P17707AMD1More
Alprazolamhsa00340Histidine metabolism4.52E-021O95954FTCDMore
Alprazolamhsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Alprazolamhsa00500Starch and sucrose metabolism5.48E-073O43451, P46976, P06737MGAM, GYG1, PYGLMore
Alprazolamhsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Alprazolamhsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Alprazolamhsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Alprazolamhsa00533Glycosaminoglycan biosynthesis - keratan sulfate6.96E-041Q9NY97B3GNT2More
Alprazolamhsa00561Glycerolipid metabolism2.21E-023O14494, P06280, P23743PLPP1, GLA, DGKAMore
Alprazolamhsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.01E-021Q14442PIGHMore
Alprazolamhsa00564Glycerophospholipid metabolism8.47E-045P48651, Q9Y6K0, P35790, Q9Y259, P49619PTDSS1, CEPT1, CHKA, CHKB, DGKGMore
Alprazolamhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Alprazolamhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Alprazolamhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Alprazolamhsa00600Sphingolipid metabolism3.96E-023Q9BX95, O14494, P06280SGPP1, PLPP1, GLAMore
Alprazolamhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Alprazolamhsa00630Glyoxylate and dicarboxylate metabolism4.29E-032P40925, P15104MDH1, GLULMore
Alprazolamhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Alprazolamhsa00670One carbon pool by folate1.33E-022P04818, Q99707TYMS, MTRMore
Alprazolamhsa00730Thiamine metabolism2.39E-052P05186, P24666ALPL, ACP1More
Alprazolamhsa00740Riboflavin metabolism4.77E-021P30043BLVRBMore
Alprazolamhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Alprazolamhsa00790Folate biosynthesis1.04E-023Q92820, P05186, P42330GGH, ALPL, AKR1C3More
Alprazolamhsa00830Retinol metabolism3.93E-023P00352, Q9BPW9, O75911ALDH1A1, DHRS9, DHRS3More
Alprazolamhsa00860Porphyrin and chlorophyll metabolism1.70E-043P36551, P53004, P30043CPOX, BLVRA, BLVRBMore
Alprazolamhsa00910Nitrogen metabolism2.66E-033P22748, P15104, P49448CA4, GLUL, GLUD2More
Alprazolamhsa00970Aminoacyl-tRNA biosynthesis2.41E-054O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Alprazolamhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Alprazolamhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Alprazolamhsa00983Drug metabolism - other enzymes2.57E-043P04183, P32320, P05164TK1, CDA, MPOMore
Alprazolamhsa01100Metabolic pathways3.69E-0446Q9NR34, Q9Y234, P35790, Q9Y259, P05089, Q16772, P30041, P19367, P48426, P22557, P32320, Q13956, P20839, P22748, P55809, P06280, Q16875, O43286, O43451, Q9Y6K0, P05186, P24666, P15121, P08237, P49619, O95861, O95954, Q9HCC0, P33121, Q02318, Q86VZ5, P48651, P57054, Q9UBX8, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P35573, P06737, Q969G6, P14927MAN1C1, LIPT1, CHKA, CHKB, ARG1, GSTA3, PRDX6, HK1, PIP4K2A, ALAS2, CDA, PDE6H, IMPDH1, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, CEPT1, ALPL, ACP1, AKR1B1, PFKM, DGKG, BPNT1, FTCD, MCCC2, ACSL1, CYP27A1, SGMS1, PTDSS1, PIGP, B4GALT6, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, AGL, PYGL, RFK, UQCRBMore
Alprazolamhsa012102-Oxocarboxylic acid metabolism6.96E-041P50213IDH3AMore
Alprazolamhsa01230Biosynthesis of amino acids2.34E-046P51854, P60891, Q99707, P50213, P15104, P37837TKTL1, PRPS1, MTR, IDH3A, GLUL, TALDO1More
Alprazolamhsa01240Biosynthesis of cofactors3.44E-035Q969G6, P36551, P22557, O60701, Q9Y234RFK, CPOX, ALAS2, UGDH, LIPT1More
Alprazolamhsa01522Endocrine resistance4.74E-023P22694, P10415, Q13323PRKACB, BCL2, BIKMore
Alprazolamhsa01523Antifolate resistance3.45E-075P41439, P41440, Q92820, P04818, P01375FOLR3, SLC19A1, GGH, TYMS, TNFMore
Alprazolamhsa01524Platinum drug resistance4.78E-021P31751AKT2More
Alprazolamhsa02010ABC transporters9.42E-063P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Alprazolamhsa03008Ribosome biogenesis in eukaryotes2.40E-035P19784, P67870, O14980, O60832, Q9BVP2CSNK2A2, CSNK2B, XPO1, DKC1, GNL3More
Alprazolamhsa03013RNA transport1.83E-0820P62826, O14980, P52298, O14893, P61326, P38919, Q9UBU9, P37198, Q7Z3B4, P35658, P63279, P68104, Q14152, P55884, Q14240, Q9BZI7, P23588, Q9Y6A5, Q14232, Q06787RAN, XPO1, NCBP2, GEMIN2, MAGOH, EIF4A3, NXF1, NUP62, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3B, EIF4A2, UPF3B, EIF4B, TACC3, EIF2B1, FMR1More
Alprazolamhsa03015mRNA surveillance pathway4.81E-022Q9BZI7, O94913UPF3B, PCF11More
Alprazolamhsa03020RNA polymerase5.54E-064P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Alprazolamhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Alprazolamhsa03040Spliceosome4.00E-0816Q14562, O43143, O60508, P08579, P26368, O75940, O75494, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, SMNDC1, FUSIP1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Alprazolamhsa03050Proteasome9.50E-041P55036PSMD4More
Alprazolamhsa03060Protein export2.33E-042P37108, Q15005SRP14, SPCS2More
Alprazolamhsa03320PPAR signaling pathway2.42E-034Q6PCB7, Q9UNU6, Q13133, Q02318SLC27A1, CYP8B1, NR1H3, CYP27A1More
Alprazolamhsa03410Base excision repair7.59E-031P27695APEX1More
Alprazolamhsa03450Non-homologous end-joining3.17E-032Q9NP87, P13010POLM, XRCC5More
Alprazolamhsa04012ErbB signaling pathway1.91E-023P16333, P19174, P01106NCK1, PLCG1, MYCMore
Alprazolamhsa04014Ras signaling pathway2.75E-0413P31751, P42338, P20827, Q9NRA1, P49767, Q13009, P17252, Q7LDG7, P0DP23, P62873, P63218, P50151, P19174AKT2, PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, PRKCA, RASGRP2, CALM1, GNB1, GNG5, GNG10, PLCG1More
Alprazolamhsa04015Rap1 signaling pathway4.45E-0412P20827, Q9NRA1, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P31751, P0DP23, P17252, P19174EFNA1, PDGFC, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, AKT2, CALM1, PRKCA, PLCG1More
Alprazolamhsa04020Calcium signaling pathway3.56E-0411Q08828, P17252, P19174, P0DP24, P0DP23, P05141, P51828, P20020, P23634, Q9NRA1, P49767ADCY1, PRKCA, PLCG1, CALM2, CALM1, SLC25A5, ADCY7, ATP2B1, ATP2B4, PDGFC, VEGFCMore
Alprazolamhsa04022cGMP-PKG signaling pathway2.81E-046P18848, P31751, Q08828, P51828, P05141, P0DP23ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1More
Alprazolamhsa04024cAMP signaling pathway3.73E-0612P63092, Q08828, P51828, P42338, P31751, P26678, P0DP24, P0DP23, P23634, P61586, Q13370, Q13009GNAS, ADCY1, ADCY7, PIK3CB, AKT2, PLN, CALM2, CALM1, ATP2B4, RHOA, PDE3B, TIAM1More
Alprazolamhsa04060Cytokine-cytokine receptor interaction1.91E-0519P14784, P27930, P14778, P37173, P08476, P26842, Q06643, Q13651, Q9HBE5, P78552, P25024, Q9UBD3, P47992, P01375, P09341, P80075, P18510, P01730, Q93038IL2RB, IL1R2, IL1R1, TGFBR2, INHBA, CD27, LTB, IL10RA, IL21R, IL13RA1, CXCR1, XCL2, XCL1, TNF, CXCL1, CCL8, IL1RN, CD4, TNFRSF25More
Alprazolamhsa04061Viral protein interaction with cytokine and cytokine receptor2.72E-0811Q8NHW4, P09341, P19875, P25024, P25025, P61073, P47992, Q9UBD3, Q13651, P14784, P01375CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, CXCR4, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Alprazolamhsa04062Chemokine signaling pathway1.51E-0517P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q08881, Q7LDG7, Q13009, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITK, RASGRP2, TIAM1, PIK3R5More
Alprazolamhsa04064NF-kappa B signaling pathway9.01E-1424P10415, Q13489, O00463, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, P67870, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, TRAF5, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, CSNK2B, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Alprazolamhsa04070Phosphatidylinositol signaling system2.01E-0612P19174, P0DP23, Q14643, P42338, O14986, P23743, Q86XP1, Q16760, P48426, P27987, Q96DU7, P17252PLCG1, CALM1, ITPR1, PIK3CB, PIP5K1B, DGKA, DGKH, DGKD, PIP4K2A, ITPKB, ITPKC, PRKCAMore
Alprazolamhsa04071Sphingolipid signaling pathway2.03E-048P17252, Q9H228, P01375, Q13510, Q13362, Q9BX95, P10415, Q9UQC2PRKCA, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, BCL2, GAB2More
Alprazolamhsa04072Phospholipase D signaling pathway5.40E-0513P31751, P42338, P61586, P43657, P25024, P25025, P19174, O14986, Q15438, P63092, Q08828, P51828, Q16760AKT2, PIK3CB, RHOA, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, GNAS, ADCY1, ADCY7, DGKDMore
Alprazolamhsa04080Neuroactive ligand-receptor interaction1.26E-0511P08311, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, P14416, P07550, P35318CTSG, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, DRD2, ADRB2, ADMMore
Alprazolamhsa04110Cell cycle8.49E-099Q9UBD5, P06493, O60566, Q14683, O75293, P30304, P33981, P42773, P01106ORC3, CDK1, BUB1B, SMC1A, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Alprazolamhsa04114Oocyte meiosis3.12E-0712Q9Y6D9, P51812, Q02750, P0DP24, P0DP23, P16298, Q17RY0, Q08828, P51828, P27348, Q13362, Q14738MAD1L1, RPS6KA3, MAP2K1, CALM2, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, YWHAQ, PPP2R5C, PPP2R5DMore
Alprazolamhsa04115p53 signaling pathway3.34E-022P31350, P06493RRM2, CDK1More
Alprazolamhsa04120Ubiquitin mediated proteolysis2.12E-058Q9UBT2, Q14145, Q13042, Q13191, P62837, Q15751, Q14669, Q7Z6Z7SAE2, KEAP1, CDC16, CBLB, UBE2D2, HERC1, TRIP12, HUWE1More
Alprazolamhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Alprazolamhsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Alprazolamhsa04140Autophagy - animal5.72E-0410P31751, Q7L523, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9AKT2, RRAGA, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Alprazolamhsa04141Protein processing in endoplasmic reticulum2.78E-023P07384, O95487, O95816CAPN1, SEC24B, BAG2More
Alprazolamhsa04142Lysosome1.27E-0411Q99437, P25774, P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916, Q04900, Q9Y227ATP6V0B, CTSS, HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2, CD164, ENTPD4More
Alprazolamhsa04144Endocytosis8.92E-0511P0DMV8, Q9H444, O75351, P62491, P42566, Q96B97, Q15438, Q14161, Q96QK1, Q9UMY4, Q9UNH7HSPA1A, CHMP4B, VPS4B, RAB11A, EPS15, SH3KBP1, PSCD1, GIT2, VPS35, SNX12, SNX6More
Alprazolamhsa04145Phagosome6.97E-0615O75015, P60709, Q15075, Q15080, P14598, Q13509, P68371, Q13488, Q99437, P05164, P78380, O60603, P35443, P13765, P25774FCGR3B, ACTB, EEA1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, ATP6V0B, MPO, OLR1, TLR2, THBS4, HLA-DOB, CTSSMore
Alprazolamhsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Alprazolamhsa04151PI3K-Akt signaling pathway5.33E-0320P42338, P43657, P25116, P20827, P49767, Q13362, P08238, Q8WYR1, P62873, P63218, P50151, P16144, O15335, Q13751, O60603, P14784, P01568, P10415, P17252, P30281PIK3CB, P2RY5, F2R, EFNA1, VEGFC, PPP2R5C, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGB4, CHAD, LAMB3, TLR2, IL2RB, IFNA21, BCL2, PRKCA, CCND3More
Alprazolamhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Alprazolamhsa04211Longevity regulating pathway1.88E-024P31751, Q08828, P51828, P18848AKT2, ADCY1, ADCY7, ATF4More
Alprazolamhsa04213Longevity regulating pathway - multiple species4.59E-058P31751, P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Alprazolamhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Alprazolamhsa04217Necroptosis5.03E-0619P01375, P01568, P23458, P48023, Q13489, Q9NQC7, P42224, Q14765, P08238, P01584, Q9BTM1, Q6FI13, Q99878, Q93077, P10415, Q9H444, O43633, O75351, Q08752TNF, IFNA21, JAK1, FASLG, BIRC3, CYLD, STAT1, STAT4, HSP90AB1, IL1B, H2AFJ, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CHMP4B, CHMP2A, VPS4B, PPIDMore
Alprazolamhsa04218Cellular senescence2.09E-036P01106, P31751, O75293, P30304, P06493, P0DP23MYC, AKT2, GADD45B, CDC25A, CDK1, CALM1More
Alprazolamhsa04260Cardiac muscle contraction4.60E-033P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Alprazolamhsa04261Adrenergic signaling in cardiomyocytes3.45E-0712P09493, Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP24, P0DP23, P17252, P10415, P23634TPM1, ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM2, CALM1, PRKCA, BCL2, ATP2B4More
Alprazolamhsa04270Vascular smooth muscle contraction8.40E-0410P24723, Q04759, Q14643, P0DP23, Q08828, P51828, P22694, P35579, P35749, P35318PRKCH, PRKCQ, ITPR1, CALM1, ADCY1, ADCY7, PRKACB, MYH9, MYH11, ADMMore
Alprazolamhsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Alprazolamhsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Alprazolamhsa04340Hedgehog signaling pathway3.86E-055P49841, P22694, Q13635, Q9Y496, P10415GSK3B, PRKACB, PTCH1, KIF3A, BCL2More
Alprazolamhsa04360Axon guidance1.36E-059P16333, P20827, O95631, P17252, P42338, P07332, P23528, P19174, Q06124NCK1, EFNA1, NTN1, PRKCA, PIK3CB, FES, CFL1, PLCG1, PTPN11More
Alprazolamhsa04370VEGF signaling pathway2.99E-064P16298, P31751, Q05397, Q02750PPP3CB, AKT2, PTK2, MAP2K1More
Alprazolamhsa04371Apelin signaling pathway1.14E-0411P63218, P50151, Q8WYR1, P31751, Q08828, P51828, Q14814, Q14344, Q13485, P84022, P0DP23GNG5, GNG10, PIK3R5, AKT2, ADCY1, ADCY7, MEF2D, GNA13, SMAD4, SMAD3, CALM1More
Alprazolamhsa04380Osteoclast differentiation2.07E-0510Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Alprazolamhsa04390Hippo signaling pathway2.17E-035P63261, P84022, Q13485, O15105, Q13489ACTG1, SMAD3, SMAD4, SMAD7, BIRC3More
Alprazolamhsa04510Focal adhesion4.07E-023O14986, P61586, Q16363PIP5K1B, RHOA, LAMA4More
Alprazolamhsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Alprazolamhsa04530Tight junction2.07E-046P63261, P16989, P56750, Q9Y478, Q92974, Q14247ACTG1, CSDA, CLDN17, PRKAB1, ARHGEF2, CTTNMore
Alprazolamhsa04540Gap junction4.34E-056P17252, P22694, Q13509, P68371, Q9NRA1, Q14643PRKCA, PRKACB, TUBB3, TUBB2C, PDGFC, ITPR1More
Alprazolamhsa04550Signaling pathways regulating pluripotency of stem cells4.73E-023Q13873, Q02750, Q86SE9BMPR2, MAP2K1, PCGF5More
Alprazolamhsa04610Complement and coagulation cascades5.97E-092P00734, P0C0L4F2, C4AMore
Alprazolamhsa04612Antigen processing and presentation9.26E-1110P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, TNFMore
Alprazolamhsa04613Neutrophil extracellular trap formation5.08E-0723P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, P04908, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P14598, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Alprazolamhsa04620Toll-like receptor signaling pathway4.91E-043P01584, P31751, Q8NHW4IL1B, AKT2, CCL4L2More
Alprazolamhsa04621NOD-like receptor signaling pathway3.51E-039Q9H1Y0, P43490, O00463, Q05823, P01375, P49913, P59665, P59666, P12838ATG5, PBEF1, TRAF5, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Alprazolamhsa04622RIG-I-like receptor signaling pathway1.81E-021Q9NQC7CYLDMore
Alprazolamhsa04623Cytosolic DNA-sensing pathway3.00E-085P01584, P01568, P25963, Q9Y535, Q8NHW4IL1B, IFNA21, NFKBIA, POLR3H, CCL4L2More
Alprazolamhsa04625C-type lectin receptor signaling pathway7.60E-068Q9ULY5, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Alprazolamhsa04630JAK-STAT signaling pathway4.54E-023P31751, P23458, Q13651AKT2, JAK1, IL10RAMore
Alprazolamhsa04640Hematopoietic cell lineage6.77E-1117P13612, P21926, P14778, P27930, P11215, P15144, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375ITGA4, CD9, IL1R1, IL1R2, ITGAM, ANPEP, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNFMore
Alprazolamhsa04650Natural killer cell mediated cytotoxicity4.04E-2116P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Alprazolamhsa04657IL-17 signaling pathway1.04E-0712P25963, P08238, O00463, Q07955, Q16539, P49841, P09341, P14780, P04141, P80188, P01375, P06702NFKBIA, HSP90AB1, TRAF5, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, CSF2, LCN2, TNF, S100A9More
Alprazolamhsa04658Th1 and Th2 cell differentiation6.97E-2113Q04759, P07766, P20963, P09693, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Alprazolamhsa04659Th17 cell differentiation6.01E-1719P25963, Q04759, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, P40189, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, IL6ST, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Alprazolamhsa04660T cell receptor signaling pathway8.23E-1519P01375, P04141, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P16333, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P29350TNF, CSF2, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, PTPN6More
Alprazolamhsa04662B cell receptor signaling pathway7.36E-047P31751, P42338, P60033, P13164, P07948, P21854, Q8N149AKT2, PIK3CB, CD81, IFITM1, LYN, CD72, LILRA2More
Alprazolamhsa04664Fc epsilon RI signaling pathway7.42E-048P01375, P31751, Q16539, P42338, Q9UQC2, P07948, P19174, P09917TNF, AKT2, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5More
Alprazolamhsa04666Fc gamma R-mediated phagocytosis3.08E-023P42338, P23528, P14598PIK3CB, CFL1, NCF1More
Alprazolamhsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Alprazolamhsa04672Intestinal immune network for IgA production3.36E-044P29965, P10747, P13765, P13612CD40LG, CD28, HLA-DOB, ITGA4More
Alprazolamhsa04713Circadian entrainment4.08E-058P0DP23, P17252, P62873, Q14643, Q08828, P51828, P63092, O15055CALM1, PRKCA, GNB1, ITPR1, ADCY1, ADCY7, GNAS, PER2More
Alprazolamhsa04714Thermogenesis1.73E-047Q16539, P15336, P63261, P33121, Q9Y478, Q16718, O14521MAPK14, ATF2, ACTG1, ACSL1, PRKAB1, NDUFA5, SDHDMore
Alprazolamhsa04720Long-term potentiation1.96E-058P17252, P16298, P0DP23, P51812, P18848, Q08828, Q02750, Q14643PRKCA, PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1, ITPR1More
Alprazolamhsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Alprazolamhsa04722Neurotrophin signaling pathway1.26E-035P31751, P49841, O43524, P48023, P0DP23AKT2, GSK3B, FOXO3, FASLG, CALM1More
Alprazolamhsa04723Retrograde endocannabinoid signaling2.51E-035Q14643, P17252, P48169, P62873, Q16718ITPR1, PRKCA, GABRA4, GNB1, NDUFA5More
Alprazolamhsa04724Glutamatergic synapse3.65E-022P63092, P62873GNAS, GNB1More
Alprazolamhsa04725Cholinergic synapse7.01E-059Q08828, P51828, P22694, Q14643, P17252, P62873, P18848, P31751, P10415ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, GNB1, ATF4, AKT2, BCL2More
Alprazolamhsa04726Serotonergic synapse2.52E-022P63092, P62873GNAS, GNB1More
Alprazolamhsa04728Dopaminergic synapse7.82E-058Q14643, P17252, P62873, P31751, P18848, Q13362, Q14738, P0DP23ITPR1, PRKCA, GNB1, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Alprazolamhsa04740Olfactory transduction2.41E-021P0DP23CALM1More
Alprazolamhsa04744Phototransduction4.48E-052P62873, P0DP23GNB1, CALM1More
Alprazolamhsa04750Inflammatory mediator regulation of TRP channels2.58E-059P14778, P01584, Q08828, P51828, P19174, P42338, P24723, Q04759, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1More
Alprazolamhsa04910Insulin signaling pathway2.83E-045P0DP23, P22694, P06737, P31751, P49841CALM1, PRKACB, PYGL, AKT2, GSK3BMore
Alprazolamhsa04911Insulin secretion2.40E-023Q08828, P51828, P18848ADCY1, ADCY7, ATF4More
Alprazolamhsa04912GnRH signaling pathway1.52E-036P17252, Q08828, P51828, P18848, Q14643, P0DP23PRKCA, ADCY1, ADCY7, ATF4, ITPR1, CALM1More
Alprazolamhsa04913Ovarian steroidogenesis2.72E-022P42330, P22694AKR1C3, PRKACBMore
Alprazolamhsa04914Progesterone-mediated oocyte maturation8.22E-057Q17RY0, P42338, Q13370, Q9Y6D9, P08238, P51812, Q02750CPEB4, PIK3CB, PDE3B, MAD1L1, HSP90AB1, RPS6KA3, MAP2K1More
Alprazolamhsa04915Estrogen signaling pathway2.46E-047P18848, Q08828, P51828, P31751, P0DMV8, P0DP23, Q15788ATF4, ADCY1, ADCY7, AKT2, HSPA1A, CALM1, NCOA1More
Alprazolamhsa04916Melanogenesis4.69E-033P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Alprazolamhsa04917Prolactin signaling pathway2.41E-021P31751AKT2More
Alprazolamhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Alprazolamhsa04920Adipocytokine signaling pathway3.41E-033Q06124, Q9Y478, P31751PTPN11, PRKAB1, AKT2More
Alprazolamhsa04922Glucagon signaling pathway2.33E-035Q12778, P31751, Q13370, P0DP23, Q14643FOXO1, AKT2, PDE3B, CALM1, ITPR1More
Alprazolamhsa04923Regulation of lipolysis in adipocytes5.39E-056Q08828, P51828, P07550, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2More
Alprazolamhsa04924Renin secretion1.14E-075P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Alprazolamhsa04925Aldosterone synthesis and secretion3.49E-046P18848, Q08828, P51828, P0DP24, P0DP23, P23634ATF4, ADCY1, ADCY7, CALM2, CALM1, ATP2B4More
Alprazolamhsa04926Relaxin signaling pathway2.46E-024P31751, P18848, Q08828, P51828AKT2, ATF4, ADCY1, ADCY7More
Alprazolamhsa04927Cortisol synthesis and secretion8.09E-045Q14643, P18848, Q08828, P51828, P22694ITPR1, ATF4, ADCY1, ADCY7, PRKACBMore
Alprazolamhsa04928Parathyroid hormone synthesis, secretion and action1.02E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Alprazolamhsa04929GnRH secretion1.81E-021P31751AKT2More
Alprazolamhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Alprazolamhsa04932Non-alcoholic fatty liver disease8.30E-0814P31751, P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, Q16718, O95298, O14521AKT2, TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, SDHDMore
Alprazolamhsa04933AGE-RAGE signaling pathway in diabetic complications4.38E-069P84022, Q13485, P42224, P10415, P42338, Q12778, P49767, P17252, P19174SMAD3, SMAD4, STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1More
Alprazolamhsa04934Cushing syndrome5.04E-036Q14643, P18848, Q08828, P51828, P22694, P04628ITPR1, ATF4, ADCY1, ADCY7, PRKACB, WNT1More
Alprazolamhsa04935Growth hormone synthesis, secretion and action1.88E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Alprazolamhsa04940Type I diabetes mellitus6.87E-042P48023, P01375FASLG, TNFMore
Alprazolamhsa04961Endocrine and other factor-regulated calcium reabsorption2.09E-022P23634, P62491ATP2B4, RAB11AMore
Alprazolamhsa04964Proximal tubule bicarbonate reclamation2.08E-043P22748, P00918, P49448CA4, CA2, GLUD2More
Alprazolamhsa04966Collecting duct acid secretion1.26E-043Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Alprazolamhsa04970Salivary secretion3.77E-078P07550, Q08828, P51828, P22694, Q14643, P23634, P0DP24, P0DP23ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B4, CALM2, CALM1More
Alprazolamhsa04971Gastric acid secretion4.91E-044Q08828, P51828, P15311, P0DP23ADCY1, ADCY7, VIL2, CALM1More
Alprazolamhsa04972Pancreatic secretion3.95E-045P23634, P63092, P51828, P62491, P61586ATP2B4, GNAS, ADCY7, RAB11A, RHOAMore
Alprazolamhsa04973Carbohydrate digestion and absorption4.61E-033O43451, P42338, P31751MGAM, PIK3CB, AKT2More
Alprazolamhsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Alprazolamhsa04976Bile secretion1.12E-066O43315, Q08828, P51828, P22694, P08183, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Alprazolamhsa05010Alzheimer disease7.98E-0620O15239, Q16718, O95298, O14521, P13073, P12074, Q14643, Q00535, O75460, P0DP23, P01584, O95197, P18848, Q13509, P68371, P67870, P31751, P05141, Q08752, P28070NDUFA1, NDUFA5, NDUFC2, SDHD, COX4I1, COX6A1, ITPR1, CDK5, ERN1, CALM1, IL1B, RTN3, ATF4, TUBB3, TUBB2C, CSNK2B, AKT2, SLC25A5, PPID, PSMB4More
Alprazolamhsa05012Parkinson disease2.01E-037Q16718, O14521, Q14643, P19174, P0DP23, Q13509, P68371NDUFA5, SDHD, ITPR1, PLCG1, CALM1, TUBB3, TUBB2CMore
Alprazolamhsa05016Huntington disease1.51E-0410O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12More
Alprazolamhsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Alprazolamhsa05020Prion disease1.31E-039Q16718, O14521, Q14643, Q13509, P68371, P49841, P14598, Q15080, Q16539NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, GSK3B, NCF1, NCF4, MAPK14More
Alprazolamhsa05022Pathways of neurodegeneration - multiple diseases1.26E-0621Q14643, Q13509, P68371, P49841, P10415, Q16718, O95298, O14521, Q8TEV9, O75460, P18848, Q13561, P19174, P05141, P17252, Q16539, Q00535, P01584, Q08752, P0DP23, P28070ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, NDUFC2, SDHD, SMCR8, ERN1, ATF4, DCTN2, PLCG1, SLC25A5, PRKCA, MAPK14, CDK5, IL1B, PPID, CALM1, PSMB4More
Alprazolamhsa05030Cocaine addiction4.19E-021Q00535CDK5More
Alprazolamhsa05031Amphetamine addiction4.78E-021P0DP23CALM1More
Alprazolamhsa05032Morphine addiction9.04E-055P62873, P48169, P78334, P63092, P32298GNB1, GABRA4, GABRE, GNAS, GRK4More
Alprazolamhsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Alprazolamhsa05100Bacterial invasion of epithelial cells2.85E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Alprazolamhsa05110Vibrio cholerae infection2.98E-055Q13488, Q99437, P17252, P19174, P60709TCIRG1, ATP6V0B, PRKCA, PLCG1, ACTBMore
Alprazolamhsa05120Epithelial cell signaling in Helicobacter pylori infection2.39E-056Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Alprazolamhsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Alprazolamhsa05131Shigellosis2.27E-028P68431, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPIDMore
Alprazolamhsa05132Salmonella infection5.61E-0513P25963, P08238, Q9UJU2, Q13489, P10415, P04406, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371, P49754NFKBIA, HSP90AB1, LEF1, BIRC3, BCL2, GAPDH, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C, VPS41More
Alprazolamhsa05133Pertussis2.60E-042P0DP23, P0C0L4CALM1, C4AMore
Alprazolamhsa05134Legionellosis6.78E-057P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2More
Alprazolamhsa05135Yersinia infection3.29E-024Q05397, P51812, Q02750, Q96JJ3PTK2, RPS6KA3, MAP2K1, ELMO2More
Alprazolamhsa05140Leishmaniasis1.04E-0912P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, NCF4More
Alprazolamhsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Alprazolamhsa05143African trypanosomiasis6.02E-074P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Alprazolamhsa05144Malaria9.52E-067P60033, P69905, P68871, O60603, P01375, P35443, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Alprazolamhsa05145Toxoplasmosis1.02E-037P25963, P10415, Q13489, P42224, P13765, O60603, P29965NFKBIA, BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Alprazolamhsa05146Amoebiasis7.89E-1412P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Alprazolamhsa05150Staphylococcus aureus infection3.94E-0710P0C0L4, P21730, P21462, O75015, P13646, Q14532, P59665, P59666, P12838, P49913C4A, C5AR1, FPR1, FCGR3B, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Alprazolamhsa05152Tuberculosis9.47E-0511Q13488, Q99437, P0DP23, P42224, O60603, P31751, P10415, P13765, P25774, P01568, Q9UDY8TCIRG1, ATP6V0B, CALM1, STAT1, TLR2, AKT2, BCL2, HLA-DOB, CTSS, IFNA21, MALT1More
Alprazolamhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Alprazolamhsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Alprazolamhsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Alprazolamhsa05163Human cytomegalovirus infection2.12E-0922P31751, P01375, P62873, Q14643, P0DP23, P61586, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, P18848, P63092, P04637, O00463, P61769AKT2, TNF, GNB1, ITPR1, CALM1, RHOA, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, ATF4, GNAS, TP53, TRAF5, B2MMore
Alprazolamhsa05164Influenza A4.49E-025P31751, P01584, P23458, P05141, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, NXF1More
Alprazolamhsa05165Human papillomavirus infection3.10E-028P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATMMore
Alprazolamhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Alprazolamhsa05167Kaposi sarcoma-associated herpesvirus infection5.51E-0615P01568, P31751, P42224, P25963, P40189, P62873, P62879, P19174, P16298, Q14643, Q02750, P04141, P0DP23, P0CG47, Q9UJU2IFNA21, AKT2, STAT1, NFKBIA, IL6ST, GNB1, GNB2, PLCG1, PPP3CB, ITPR1, MAP2K1, CSF2, CALM1, UBB, LEF1More
Alprazolamhsa05168Herpes simplex virus 1 infection3.29E-0516P25963, P01568, Q9GZY0, P42224, Q07955, Q01130, Q13243, P42338, Q9Y2A4, Q13398, P51522, P17038, Q03923, P52738, O75820, Q9UDV6NFKBIA, IFNA21, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212More
Alprazolamhsa05169Epstein-Barr virus infection5.02E-0412P20023, P13765, P01106, Q13547, Q92769, O00463, P07948, Q13761, P24522, P07766, P09693, P20963CR2, HLA-DOB, MYC, HDAC1, HDAC2, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247More
Alprazolamhsa05170Human immunodeficiency virus 1 infection5.64E-0615P31751, Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5, P20333AKT2, MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2, TNFRSF1BMore
Alprazolamhsa05171Coronavirus disease - COVID-192.67E-039P25963, P42224, P01568, Q9UHA3, P40189, P04141, P19174, P17252, O14786NFKBIA, STAT1, IFNA21, RSL24D1, IL6ST, CSF2, PLCG1, PRKCA, NRP1More
Alprazolamhsa05200Pathways in cancer2.80E-0631Q13751, P42338, P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, Q13547, P14923, P30281, P10415, Q13489, P49767, Q12778, P31751, P43657, P25116, P62873, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P01568, P14784, P40189LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, BCL2, BIRC3, VEGFC, FOXO1, AKT2, P2RY5, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IFNA21, IL2RB, IL6STMore
Alprazolamhsa05202Transcriptional misregulation in cancer5.09E-0615Q13315, P14780, P27930, Q15744, Q16548, P11215, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522ATM, MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45AMore
Alprazolamhsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Alprazolamhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Alprazolamhsa05210Colorectal cancer1.49E-035Q9UKG1, P84022, Q13485, P10415, P37173APPL1, SMAD3, SMAD4, BCL2, TGFBR2More
Alprazolamhsa05211Renal cell carcinoma2.21E-033Q06124, Q99814, P31751PTPN11, EPAS1, AKT2More
Alprazolamhsa05212Pancreatic cancer4.08E-068P42338, P31751, Q15311, P23458, P42224, P84022, Q13485, O75293PIK3CB, AKT2, RALBP1, JAK1, STAT1, SMAD3, SMAD4, GADD45BMore
Alprazolamhsa05213Endometrial cancer4.72E-033O15169, P31751, Q02750AXIN1, AKT2, MAP2K1More
Alprazolamhsa05214Glioma1.13E-056P0DP23, P17252, P42338, P31751, P19174, O75293CALM1, PRKCA, PIK3CB, AKT2, PLCG1, GADD45BMore
Alprazolamhsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Alprazolamhsa05217Basal cell carcinoma2.83E-023Q13635, Q9UJU2, P24522PTCH1, LEF1, GADD45AMore
Alprazolamhsa05218Melanoma3.01E-021P31751AKT2More
Alprazolamhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Alprazolamhsa05220Chronic myeloid leukemia1.98E-047Q13547, Q13485, P25963, P84022, P31751, P42338, O75293HDAC1, SMAD4, NFKBIA, SMAD3, AKT2, PIK3CB, GADD45BMore
Alprazolamhsa05221Acute myeloid leukemia4.19E-021P31751AKT2More
Alprazolamhsa05222Small cell lung cancer1.36E-034P31751, Q13489, P10415, P25963AKT2, BIRC3, BCL2, NFKBIAMore
Alprazolamhsa05223Non-small cell lung cancer1.46E-047P17252, O43524, P31751, P19174, P10826, Q9HC35, O75293PRKCA, FOXO3, AKT2, PLCG1, RARB, EML4, GADD45BMore
Alprazolamhsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Alprazolamhsa05226Gastric cancer3.92E-046Q02750, P31751, O15169, P84022, Q13485, P10415MAP2K1, AKT2, AXIN1, SMAD3, SMAD4, BCL2More
Alprazolamhsa05230Central carbon metabolism in cancer4.78E-021P31751AKT2More
Alprazolamhsa05231Choline metabolism in cancer2.32E-0710P31751, Q9NRA1, Q9Y259, P19174, P23743, P49619, Q16760, O14986, O14494, P17252AKT2, PDGFC, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PLPP1, PRKCAMore
Alprazolamhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer6.95E-1016P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P29350, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Alprazolamhsa05310Asthma8.72E-053P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Alprazolamhsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Alprazolamhsa05321Inflammatory bowel disease2.75E-097O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Alprazolamhsa05322Systemic lupus erythematosus1.13E-0916O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P12814FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1More
Alprazolamhsa05323Rheumatoid arthritis1.29E-024P13765, Q13488, P10747, O60603HLA-DOB, TCIRG1, CD28, TLR2More
Alprazolamhsa05330Allograft rejection6.97E-055P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Alprazolamhsa05332Graft-versus-host disease7.02E-105P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Alprazolamhsa05340Primary immunodeficiency1.31E-045P01730, P01732, P11912, P07766, P06239CD4, CD8A, CD79A, CD3E, LCKMore
Alprazolamhsa05412Arrhythmogenic right ventricular cardiomyopathy2.17E-031P54284CACNB3More
Alprazolamhsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Alprazolamhsa05415Diabetic cardiomyopathy2.07E-0610P17252, P30405, P14598, Q15080, Q16718, O14521, Q16539, P49841, P37173, P04406PRKCA, PPIF, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, TGFBR2, GAPDHMore
Alprazolamhsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Alprazolamhsa05418Fluid shear stress and atherosclerosis4.22E-0713Q16539, P31751, P42338, Q14145, P14598, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23, P08238MAPK14, AKT2, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1, HSP90AB1More

Community members of Alprazolam (SDC: 11.10)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Reported00.32530.5650.15791.4506
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Reported00.15590.43870.16951.1248
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonReported00.13940.40970.15791.0469
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P11511CYP19A1AromatasePredicted00.815610.15882.5666
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P11766ADH5Alcohol dehydrogenase classNone3Predicted00.2650.13970.21460.6265
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P04818TYMSThymidylate synthasePredicted10.45530.27060.18930.9582
P00325ADH1BAllNonetransNoneretinol dehydrogenase [NAD(+)] ADH1BPredicted00.75050.04520.1530.6186
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P62942FKBP1APeptidylNoneprolyl cisNonetrans isomerase FKBP1APredicted10.4320.269500.7551
Q16769QPCTGlutaminylNonepeptide cyclotransferasePredicted00.02450.241600.4954
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
Q13370PDE3BcGMPNoneinhibited 3',5'Nonecyclic phosphodiesterase BPredicted00.09060.16140.35580.7239
P08311CTSGCathepsin GPredicted00.49490.18740.64781.2701
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
Q06124PTPN11TyrosineNoneprotein phosphatase nonNonereceptor type 11Predicted10.15130.45660.6131.6017
P29350PTPN6TyrosineNoneprotein phosphatase nonNonereceptor type 6Predicted10.28070.24590.56831.2004
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
Q92630DYRK2Dual specificity tyrosineNonephosphorylationNoneregulated kinase 2Predicted00.17790.349400.7877
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
Q2M2I8AAK1AP2Noneassociated protein kinase 1Predicted10.37690.328800.846
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P21453S1PR1Sphingosine 1Nonephosphate receptor 1Predicted10.14340.38470.2211.0621
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
P07195LDHBLNonelactate dehydrogenase B chainPredicted00.01670.17490.2310.5892
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P27695APEX1DNANone(apurinic or apyrimidinic site) endonucleasePredicted10.4020.2210.12170.7647
O95551TTRAPTyrosylNoneDNA phosphodiesterase 2Predicted00.20920.256900.6184
P19784CSNK2A2Casein kinase II subunit alpha'Predicted10.09660.32250.52971.2231
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P00441SOD1Superoxide dismutase [CuNoneZn]Predicted10.53850.07130.48710.8991
O15151MDM4Protein Mdm4Predicted00.10140.08980.24890.4791
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)